LOCUS       NZ_FNNQ01000001        11818 bp    DNA     linear   CON 03-MAY-2024
DEFINITION  Marininema mesophilum strain DSM 45610, whole genome shotgun
            sequence.
ACCESSION   NZ_FNNQ01000001
VERSION     NZ_FNNQ01000001.1
KEYWORDS    WGS; RefSeq.
SOURCE      Marininema mesophilum
  ORGANISM  Marininema mesophilum
            Bacteria; Bacillota; Bacilli; Bacillales; Thermoactinomycetaceae;
            Marininema.
REFERENCE   1
  AUTHORS   Varghese,N. and Submissions,S.
  TITLE     Direct Submission
  JOURNAL   Submitted (20-OCT-2016) DOE - JOINT GENOME INSTITUTE, LBNL, 2800
            Mitchell Drive, Walnut Creek, CA 94598, 94598, USA
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_900106775.1-RS_2024_05_03
            Annotation Date                   :: 05/03/2024 01:02:03
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 3,196
            CDSs (total)                      :: 3,130
            Genes (coding)                    :: 3,066
            CDSs (with protein)               :: 3,066
            Genes (RNA)                       :: 66
            rRNAs                             :: 5, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 3, 1, 1 (5S, 16S, 23S)
            partial rRNAs                     :: 2, 1 (5S, 16S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 64
            CDSs (without protein)            :: 64
            Pseudo Genes (ambiguous residues) :: 0 of 64
            Pseudo Genes (frameshifted)       :: 21 of 64
            Pseudo Genes (incomplete)         :: 50 of 64
            Pseudo Genes (internal stop)      :: 5 of 64
            Pseudo Genes (multiple problems)  :: 11 of 64
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 02:56:23
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 267565
            Orig. end                         :: 279383
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            FNNQ01000001.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..11818
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="3"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..11818
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..11818
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:6818](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..6818)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     gene            complement(189..818)
                     /locus_tag="BLV90_RS01085"
                     /old_locus_tag="SAMN05444487_101224"
     CDS             complement(189..818)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1241: lipoprotein
                     dsbF"
                     /gene_kind="other"
                     /inference="COORDINATES: protein motif:HMM:NF020123.4"
                     /locus_tag="BLV90_RS01085"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05444487_101224"
                     /product="TlpA disulfide reductase family protein"
                     /protein_id="WP_091734844.1"
                     /transl_table=11
                     /translation="MGQGGKKFWNVLIGGVLLIALGIAFWSGFSQDKKVSSPRPKKDVE
                     APASKKDGEKVDPVADIFGENQLVQKSQGKQIPNIKLSTVDGKNASLIPGKKVTVINLW
                     ASWCPPCKDEMPHLQKAYEKYKDQVDFRMVNLTTVDSMKKMKNFLSKGKYTFPVLLDQN
                     GDVGEALAAINIPQTYFVDKEGVILYHINGALTEKQLHYMMKKITS"
     gene            1009..1572
                     /locus_tag="BLV90_RS01090"
                     /old_locus_tag="SAMN05444487_101225"
     CDS             1009..1572
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF020893.4"
                     /locus_tag="BLV90_RS01090"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05444487_101225"
                     /product="VTT domain-containing protein"
                     /protein_id="WP_091734847.1"
                     /transl_table=11
                     /translation="MTQETATWLAQWGLYAIPLSILFNAFLNILGVVPSVLITGANVLL
                     WGPLWGGVISWAGEVMGATGAFFLYRLGWQRFYRKQPINWRWLTALQGWPHRRQFQSLF
                     VARLTPMVPSGAVNLLGALSHIPFSLFLLATLLGKIPSIALEVLISFDILHIEENGIRL
                     ILVVISLALATWIWRSVNKEKLAR"
     gene            complement(1748..1960)
                     /locus_tag="BLV90_RS01095"
                     /old_locus_tag="SAMN05444487_101226"
     CDS             complement(1748..1960)
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006319689.1"
                     /locus_tag="BLV90_RS01095"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05444487_101226"
                     /product="cation transporter"
                     /protein_id="WP_091734850.1"
                     /transl_table=11
                     /translation="MAITVLNVKGMSCDHCKASITGALEKISGVDKVTVDIDAGIAIVE
                     HQETISDINILKEAIEEQGYDVEEG"
     gene            complement(2040..2666)
                     /locus_tag="BLV90_RS01100"
                     /old_locus_tag="SAMN05444487_101227"
     CDS             complement(2040..2666)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_process="GO:0006810 - transport [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000571715.1"
                     /locus_tag="BLV90_RS01100"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05444487_101227"
                     /product="putative bacteriocin export ABC transporter"
                     /protein_id="WP_091734853.1"
                     /transl_table=11
                     /translation="MAITMSKLCKKLGDKVIFSNFNLEIQDGELVAITGPSGKGKSTLL
                     NIIGLLEDPDSGDIIIKGMKNPWKKEREKIKLIRHSIGYLFQNYALIEQATVSKNLDIA
                     LAYSDVEDKKKEKYRALERVGLPEKLNKKVYELSGGEQQRVALARLMLKKSEIILADEP
                     TGSLDMENREDVFNLLKELNEEGKTVVIVSHDPDIAAGCQRRVAL"
     gene            complement(2671..4857)
                     /locus_tag="BLV90_RS01105"
                     /old_locus_tag="SAMN05444487_101228"
     CDS             complement(2671..4857)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF018897.4"
                     /locus_tag="BLV90_RS01105"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05444487_101228"
                     /product="DUF1430 domain-containing protein"
                     /protein_id="WP_091734856.1"
                     /transl_table=11
                     /translation="MKKIIFMLILVSYSLSSFILTNYYEAKEVHELQSGNKERINVVGW
                     DKKEKVEEKLNKITKISRDEKTNIYKVIYKPVKTAEMPKIVLYVALGDKKKFQQQFQLK
                     WGNFFRENEPKQNFLSSHNEKDNQQIGRIKLFSPTTMAEVRLLEAAKYENIRGTYLIDS
                     QNKKILTDIKQRMKTEVGLDVKKETTLSVMDIFNDEGINSYLFVILIIVMVLICLCFLY
                     YILLSFKELAILKMFGSSDAGLIVKHLMKMSIIIHLMALGTVLLGQALILVFYNGMSKI
                     VDFSTEWMTWQLIFTCASVLISFIPFLMVYHIDIAAMLKNKKPIGLIQFLNYSSKLILT
                     SLILFLFANLFHDYQEFRVQTSNQEKWETAKRYAFYEYQADNPENLDQWEYETGLKSKK
                     LFKQADQKGAILVSPADGIVYKQKVKGFPPYDPDSGNVIYVNNNFLKENPVYDTKGNLV
                     TVPEEDDRRIVVLVPKRLAGDSQLKDTYKKWYQFKRYIDEDMRNKRIGKKKRHHPKVNV
                     TIIPIKDQQKHFLYNPEINKANQNYGVDSVLVVVNGNNMGGDSYLNYLTSGTFFAKTSQ
                     MDKPYEGLKQDIASAGLKDIILTTPSLYSKVDSYLFELKNKMKINSLLFFVLLTVGVVI
                     TVFMTLNYLERNKMIHAVKKVNGYSFYRRHYHFIGTVALLWMIIAGGAIAFKSSIVTSI
                     ILLLSVCLVLEVIIIYVVIKIGESKRTKDTLKGA"
     gene            complement(5001..5297)
                     /locus_tag="BLV90_RS01110"
                     /old_locus_tag="SAMN05444487_101229"
     CDS             complement(5001..5297)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Lactococcin_972"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR01653.1"
                     /locus_tag="BLV90_RS01110"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05444487_101229"
                     /product="lactococcin 972 family bacteriocin"
                     /protein_id="WP_091734859.1"
                     /sec_met_domain="Lactococcin_972 (E-value: 1.7e-11,
                     bitscore: 39.3, seeds: 6, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNIKKSVVSLVLCGALFTVGTTVAFAEVTHPGGGVWSHGTDSNSV
                     WSEYYHGSKTHKSSVQGVDFFVTSGWKSKGVWSTAWHKQNPNYMDYAFWSVQE"
     misc_feature    5459..5468
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: strong, score: 18.31"
                     /tool="antismash"
     gene            complement(5802..6095)
                     /locus_tag="BLV90_RS01115"
                     /old_locus_tag="SAMN05444487_101230"
     CDS             complement(5802..6095)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Lactococcin_972"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR01653.1"
                     /locus_tag="BLV90_RS01115"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05444487_101230"
                     /product="lactococcin 972 family bacteriocin"
                     /protein_id="WP_091734862.1"
                     /sec_met_domain="Lactococcin_972 (E-value: 1.5e-10,
                     bitscore: 36.2, seeds: 6, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIKKSVATLVLCGALFTVGATAAFAKMAYPGGGTWNYGENSSYV
                     YSNYYHKTKTHKSSVKGPGYYVTSGWKSKDVWTFALHKQKKGYADRTYWSTK"
     gene            complement(6525..6818)
                     /locus_tag="BLV90_RS01120"
                     /old_locus_tag="SAMN05444487_101231"
     CDS             complement(6525..6818)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Lactococcin_972"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR01653.1"
                     /locus_tag="BLV90_RS01120"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05444487_101231"
                     /product="lactococcin 972 family bacteriocin"
                     /protein_id="WP_091734865.1"
                     /sec_met_domain="Lactococcin_972 (E-value: 2.2e-12,
                     bitscore: 42.1, seeds: 6, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIKKSVATLVLCGALFTVGATAAFAKVTHPGGGVWSYGEDSVSV
                     WSEYYHGSKTHKSSVKGPDYYVSSGWKSKGVWSTAWHKQKPGYNDEVFWGTQ"
     misc_feature    6871..6884
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: medium, score: 22.69"
                     /tool="antismash"
     misc_feature    complement(6874..6890)
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 23.52"
                     /tool="antismash"
     misc_feature    6913..6922
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: strong, score: 18.31"
                     /tool="antismash"
     misc_feature    6936..6949
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 22.39"
                     /tool="antismash"
     gene            complement(7082..7723)
                     /locus_tag="BLV90_RS01125"
                     /old_locus_tag="SAMN05444487_101232"
     CDS             complement(7082..7723)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="resistance (resist) ClassB"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1170: metallo-beta-lactamase family protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003336655.1"
                     /locus_tag="BLV90_RS01125"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05444487_101232"
                     /product="MBL fold metallo-hydrolase"
                     /protein_id="WP_245726203.1"
                     /transl_table=11
                     /translation="MIQVESFTLGYVMTNCYLLYRKQGGEGIVIDPGTEPDALLKRIAE
                     LQLSVKEILLTHAHFDHIGGVEAVREATGASVTIHQAETEWLTDSRLNGSGMFPGIPEI
                     SCQPADKVLHGGETISVLGEKVKVAHTPGHSPGSLSFIFPQMVFSGDVLFAGSIGRTDL
                     PGGDHQTLMRSIHDTIMELPEETIVYSGHGPVTTIGREQESNPFVTGMIG"
     gene            7976..9400
                     /locus_tag="BLV90_RS01130"
                     /old_locus_tag="SAMN05444487_101233"
     CDS             7976..9400
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1170: metallo-beta-lactamase family protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012955.4"
                     /locus_tag="BLV90_RS01130"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05444487_101233"
                     /product="MBL fold metallo-hydrolase"
                     /protein_id="WP_091734867.1"
                     /transl_table=11
                     /translation="MYFHRFFYEPLAHASFLVGCTHSQEALVVDPGRDITPYLELAHRE
                     GMQITAIAETHIHADLLSGAKELAERTHASLYLSGEGGAGDYAWAQDLPHRFLRDNDEF
                     TIGGLRIKALHTPGHTPEHLSFLLTQETVRTPLGLFTGDFLFVGDAGRPDLLEKAIGVQ
                     GNAAISAKALYHSIQRIRSLPDHLQIWPSHGAGSACGKALGSLPMSTLGYEKQTSWVFQ
                     DQDIASFLKKIQTGQPTPPPYFSRMKKWNRSHLPLLRERPKPERFTAEDIRQLDFGKDG
                     FYLVDTRPAGEFLQSHIKGSLCLPHNRSFIQWAGWFLEDAPPLVVIVDEKRQKQLERDL
                     AMIGLDHIAGILPTSEITRFQASELERVIEAEPSEIAQRVNQGDVTVIDVRNDSEWEAG
                     HLPQALHIPLTQLTSQLDTLSKDRPLLLQCKAGGRSAIASSLLQAQGYDVINLRGGWDR
                     WMECNLPTCSSPASSS"
     misc_feature    complement(9563..9578)
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: weak,
                     score: 16.79"
                     /tool="antismash"
     gene            9713..9892
                     /locus_tag="BLV90_RS01135"
                     /old_locus_tag="SAMN05444487_101234"
     CDS             9713..9892
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF021480.4"
                     /locus_tag="BLV90_RS01135"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05444487_101234"
                     /product="DUF2197 domain-containing protein"
                     /protein_id="WP_091734870.1"
                     /transl_table=11
                     /translation="MTVTCILCEDSFVPTSIQAKKIRKHPHRIFLCPACHERVAKKAKE
                     SPHLIQVKPSLPHL"
     gene            complement(9889..10191)
                     /locus_tag="BLV90_RS01140"
                     /old_locus_tag="SAMN05444487_101235"
     CDS             complement(9889..10191)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005832754.1"
                     /locus_tag="BLV90_RS01140"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05444487_101235"
                     /product="hypothetical protein"
                     /protein_id="WP_091734873.1"
                     /transl_table=11
                     /translation="MRLEEALFNWLQIRLVWNARPKDRSAEETVRFFQQMLQEDHGVKE
                     LSIAVEANKYWVSWQKDGDEESRPYGREQAESLLRSIETEPKYNAAWDCGLEDKS"
     gene            complement(10294..10587)
                     /locus_tag="BLV90_RS01145"
                     /old_locus_tag="SAMN05444487_101236"
     CDS             complement(10294..10587)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009709140.1"
                     /locus_tag="BLV90_RS01145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05444487_101236"
                     /product="YlaH-like family protein"
                     /protein_id="WP_091734877.1"
                     /transl_table=11
                     /translation="MEGINEWLRGEPALAYLLILVLTSIIYKVAFARRLPILKAAVVYV
                     VLAIGCILFWALFFLKFPMIEILSVTVVMIAIARIRMGTNHRKEQEGPPTTS"
     gene            complement(10626..11471)
                     /locus_tag="BLV90_RS01150"
                     /old_locus_tag="SAMN05444487_101237"
     CDS             complement(10626..11471)
                     /EC_number="3.1.21.2"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0008270 - zinc ion binding [Evidence IEA]"
                     /GO_function="GO:0016888 - endodeoxyribonuclease activity,
                     producing 5'-phosphomonoesters [Evidence IEA]"
                     /GO_process="GO:0006281 - DNA repair [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009709141.1"
                     /locus_tag="BLV90_RS01150"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05444487_101237"
                     /product="deoxyribonuclease IV"
                     /protein_id="WP_091734880.1"
                     /transl_table=11
                     /translation="MKLGCHISVAKGFSKASFQAAELGAASFQVFTKNPRGLRPKKVDY
                     ADAEKGVAFCREKGITLVAHTPYITNLSTPKVDLHEVTVRSIKEDLHIAETYGAIGAVV
                     HCGKHVGEGEEEGTRRMVETLNEILADYDGDTLLLLENTAGQGTELGLKIEDLVKIREA
                     TDYPEKIGFCFDTCHGFAAGAWNLPTFDELIEKMEETGYLKSLIAIHFNDSKAPYESRK
                     DRHEKIGKGEIGAEALTRFLHCEQLEGIPIILETPVEKEEEYAEEIQYLHQLKEGTPAH
                     "
ORIGIN
        1 tcgttttaat gccgacgacc gcttttgatc ctgcaattca ttgacagaaa cccctgtaat
       61 atatgacaaa taggacggat ataagggcaa gcaacaagga gagataaatg agagaattcc
      121 cgctccaaaa gctaccccta cattaatatc tgccatttag tcccctcctc tcccaaggaa
      181 tatccccatt aagaggtgat ttttttcatc atataatgaa gctgtttttc agttaacgca
      241 ccgttaatgt gataaagaat gacaccctct ttatccacga aataggtctg aggaatattg
      301 atagctgcta atgcttcacc tacatctcca ttttgatcaa gaagaacagg gaaggtgtat
      361 ttacctttgc ttagaaagtt cttcatcttt ttcatcgagt ctaccgtggt taaattcacc
      421 atacgaaagt ctacttgatc cttgtatttc tcataggcct tttgcagatg tggcatctca
      481 tccttacaag gcgggcacca ggaagcccat aaattgatta ccgtaacttt tttaccagga
      541 atgagagaag cgtttttacc atcgactgtg gataacttaa tattgggaat ctgcttaccc
      601 tgtgattttt gtaccaactg attttcccca aaaatatccg ctacaggatc tactttttct
      661 ccatcctttt tggaggcagg tgcttctacg tccttttttg gacggggaga agatactttt
      721 ttatcctggg aaaaacctga ccaaaacgct atacctaatg ctatcaacaa cactccgccg
      781 ataagtacat tccaaaattt cttaccccct tggcccatgg ccacccctcc aatgacttgc
      841 gaaatcttcc tcgttctctt atcttactca cccattataa ccgaacggat gaaacactta
      901 acctaccaca gttgaatgac aaaagataga caattgcgcc tttaacttgg caagccagtt
      961 tgtctccctt atgatttaga gtatatttct acttatcacg gagggacaat gacacaggaa
     1021 actgctactt ggttggctca atggggattg tacgccatcc ccttaagcat tctattcaat
     1081 gcttttctca atatccttgg agttgtgccc agcgtcctga ttactggtgc caatgtcttg
     1141 ctatggggtc ccttatgggg aggagtcatc tcttgggctg gggaagtgat gggagccact
     1201 ggtgcttttt ttctctatcg gttgggttgg caacgttttt atcgcaaaca accaatcaat
     1261 tggcgttggc taaccgctct ccaaggttgg cctcatcgtc gacaatttca atccctattc
     1321 gttgcccgtc tcactcccat ggtaccctct ggagcagtca atctccttgg agcgctctcc
     1381 catattccct tttcactctt tctcctggca acacttctcg gtaagattcc atccattgcc
     1441 ttggaagtct tgatcagctt cgatatactg cacatcgaag agaacggtat tcgccttatt
     1501 ctcgtggtaa tctccctcgc actcgctacc tggatatggc ggtcggtaaa taaagagaaa
     1561 ctggccagat aagtaataaa agccagttgt tcagaaaaac ttttagatat taagaaggct
     1621 atcaagcgct cccactcgcg agtagcttcc atcacccacg cgtctggaag cggtcggcta
     1681 tcctgaaaca aatgtgaggc tgactatagg aggcaactct cccgtagtca gccctgtatc
     1741 tttgaactta cccttcttcc acatcatacc cctgctcttc gattgcttcc ttcaagatgt
     1801 tgatatcact tatcgtctcc tgatgctcca caattgcaat tccagcatcg atatccaccg
     1861 tcactttatc aacacccgat attttctcta aagcccctgt tatggatgct ttgcaatgat
     1921 cacaagacat cccctttaca ttcagtacag taatcgccat gaccgttcct ccttcttagg
     1981 gaacctttcc atttcaagga tgaactatcc actttctatc gtcaataaga aggggacact
     2041 cataatgcca ccctcctctg gcaacctgct gcaatatcag gatcatgaga aacaattacc
     2101 accgttttgc cttcttcatt tagttccttt aataggttga acacatcctc tcggttttcc
     2161 atatcaaggg agcctgtagg ctcatccgcc aagataattt cacttttttt caacattaac
     2221 ctagctaatg ctaccctttg ttgctctcct ccacttaact catatacttt tttattcaat
     2281 ttttcaggta agcccactct ttcaagtgcc cggtactttt ccttcttttt atcctctaca
     2341 tccgaataag ctagggcaat atccaagttt ttactaaccg tcgcctgttc gatcagagca
     2401 tagttttgaa acaggtaccc aattgagtgc ctaattaact tgattttctc tctttccttt
     2461 ttccacggat ttttcatccc tttaataatg atatcaccgg aatctgggtc ttctaaaagt
     2521 ccgattatat ttaaaagagt cgatttgccc ttcccactcg gtccagtaat cgccaccagt
     2581 tcaccatctt gtatttcgag attaaagtta ctaaatatca ctttatcccc tagttttttg
     2641 catagtttac tcattgtgat cgccatatta tcaagctccc tttaaggtat cttttgttct
     2701 tttgctttct ccgatcttaa tcactacgta gatgatgatg acttccagca ctaaacaaac
     2761 ggacaataaa aggatgatac tggtgacaat cgaactttta aaagctatcg cgcccccagc
     2821 tataatcatc cataagagag caaccgtacc gatgaaatgg taatgacgtc tatagaatga
     2881 ataaccattt actttcttca ccgcatgtat catcttgttt ctctccaggt agttcagagt
     2941 cataaacacc gtgatgacaa cccctacagt cagtagcaca aaaaacagaa gcgaattgat
     3001 cttcatttta tttttaagtt caaacaggta actatctact ttgctataca aagaaggtgt
     3061 cgtaagaatg atgtctttca aacctgctga cgcaatatcc tgtttcaatc cttcatatgg
     3121 cttatccatt tgacttgttt ttgcaaagaa agtaccactg gttagatagt ttagatagct
     3181 atctccaccc atattgtttc catttactac aacaagcaca gaatccacac cataattttg
     3241 attcgcttta tttatttcag gattatacaa aaagtgtttt tgctgatctt tgattgggat
     3301 gatagttaca tttaccttcg gatgatgtct tttctttttt ccaattctct tattgcgcat
     3361 atcctcatca atatacctct taaactgata ccacttctta tatgtatctt tcaattgtga
     3421 atccccagcc agccttttag gtactaaaac gacaatcctg cggtcatctt cttctggcac
     3481 tgtcactaaa ttcccctttg tatcataaac aggattttcc tttagaaagt tattatttac
     3541 ataaatcaca ttgcccgaat cgggatcata tggcggaaaa ccttttactt tctgtttata
     3601 cacgattcca tccgctggac ttactaaaat cgctcctttt tgatccgctt gtttaaatag
     3661 ctttttactt ttcaatccgg tttcatattc ccactgatct agattttcag gattatctgc
     3721 ttgatattcg tagaaagcat accttttagc agtttcccac ttttcttgat tggatgtttg
     3781 tacacgaaac tcttgataat cgtgaaagag attggcgaat aaaaatagta tcaagcttgt
     3841 aaggatcaat tttgaactgt agttaagaaa ttgaatgagc cctattggtt ttttattttt
     3901 caacatcgca gcaatatcga tgtgatagac catcaaaaaa ggaatgaaac tgattaacac
     3961 agaagcgcag gtgaaaataa gttgccaagt catccactca gtagaaaaat caacaatttt
     4021 actcatccca ttgtagaaaa ctaaaatcaa tgcttgtccg agaagtaccg ttcctaaagc
     4081 catcagatga ataatgatac tcatcttcat taagtgctta acgattaatc ccgcatcgga
     4141 actcccaaac atttttaaaa tggctaactc tttaaaactt aagaggatat agtacaagaa
     4201 acataaacat atgagaacca tcacgatgat caagatgaca aaaagatagg agttgatccc
     4261 ctcatcatta aatatatcca ttacacttag agtagtttcc ttttttacat cgagtccgac
     4321 ttctgttttc atccgttgtt ttatatccgt taaaatcttc ttattttgac tatcgatcaa
     4381 atacgtccct ctaatatttt cgtactttgc agcttctaat aatcgaacct cagccattgt
     4441 ggtaggtgaa aataatttta tccttccaat ttgctgatta tctttctcgt tatgggatga
     4501 aagaaagttt tgttttggct cgttttctct gaaaaaattc ccccatttta attgaaattg
     4561 ttgctggaac tttttcttat ctccaagtgc cacataaagc acgatttttg gcatctcagc
     4621 tgtttttacc ggtttatata tcactttgta tatatttgtt ttttcatccc gggatatttt
     4681 cgttatttta tttaattttt cttcaacctt ttctttttta tcccaaccaa ctacattgat
     4741 acgctcttta ttacccgatt gtaactcatg gacttcttta gcttcgtagt agttcgtcaa
     4801 tataaatgag gataatgaat aggatacaag aattagcatg aaaataatct ttttcatata
     4861 cttacctctt ttccattcta aagatacatc attaatacac cttcactttt ttctattata
     4921 aataggaatc ccacagtatt taccgtggga tttttatctt accgcacata aaaatatatt
     4981 actttttgaa agtgtttata ttattcttgt acactccaga atgcataatc catataattc
     5041 gggttttgtt tatgccatgc ggtagaccat acacctttgg atttccatcc tgaagttaca
     5101 aagaaatcta caccctgtac ggatgatttg tgtgttttac taccgtgata atattcggac
     5161 catacagagt ttgaatctgt cccatgactc catacaccac cacctgggtg ggttacctca
     5221 gcaaatgcta ctgttgttcc taccgtaaac aaagcaccgc aaagtactag tgagactaca
     5281 ctttttttga tattcacttt tctaaacctc cttaaatttt atatttcata catctaaaca
     5341 ctattatagt tcataatatt tagtcaatac ttatgtaaaa taaaaattat ttaattaaat
     5401 ttaaaaagta attctattaa tttaattatt tttgtatgat tattgaatat aattattttg
     5461 tttttttatg ttcagtgttt tctatcagga acaacattgg aatttcctat cccctgctac
     5521 accttatatc aacgatgggc accataggat cttggatctt catcaattaa aaagtagggg
     5581 atcacatctc atccctgata aaacacgatt tttagcgtct tagcaatatt tcctttttat
     5641 cccaataaac aacaaaagtc tatagttaca atcgggtaat aaaggataca agaattagca
     5701 tgaaaataat ctttttattc tattataaat aggaatccca cagtatttac cgtgggagtt
     5761 ttatcttact atacattaac tggtatcact ttttgaaaat attattttgt actccagtat
     5821 gttctatcag catagccctt tttttgttta tgcaatgcga aagtccatac atctttggat
     5881 ttccatcctg aagttacata gtagcctggt ccctttacgg atgatttatg tgttttagtt
     5941 ttgtgataat aattagaata tacatagctt gaattttctc catagttcca agtaccacca
     6001 cctggatagg ccatcttagc aaatgctgct gtagctccta ccgtaaacaa agcaccgcaa
     6061 agtactagtg tagctacgct ttttttgatt ttcacttttc aaacctcctt aaattttata
     6121 tttcatacat ctaaaataat aatacaactc attatattaa gtcaacacat atttaaaatt
     6181 aaaaatttaa acaaaaatat tctaccatta attctatttt ttatgaaatt atcaaattgt
     6241 atttttgtat ttaattttct attccctgct acaccttaag taaacgatag gcaaatcaac
     6301 ccttcgattt tcatccaata ttaacaatca ctcaaaaaaa gtaggggatc cctcccccac
     6361 tcatccctgt cacaaaggaa ttggattcct gttcccgccc aatcgttgtc acgggaccat
     6421 gtccagagta tacgaatggt ttcctctggt aattacctta tcgtatatgg aagttttatc
     6481 ttaccataca ttaaaatgta tcactttttg aaaatttata aatattattg tgtaccccag
     6541 aatacttcat cattataacc cggtttttgt ttatgccatg cggtagacca tacacctttg
     6601 gatttccatc ctgaacttac atagtaatct ggtcccttta cggatgattt gtgtgtttta
     6661 ctaccgtgat aatattcgga ccatacagag actgaatctt ctccataact ccatacacca
     6721 ccacctggat gggttacctt tgcaaatgct gctgttgctc ctaccgtaaa caaagcaccg
     6781 caaagtacta gtgtagctac gctttttttg attttcactt ttcaaacctc ctttaatttt
     6841 atatttcgta catctaatat gtaaaataat attttttaat taaattaaaa caaaaataat
     6901 tctattaatt tttgtttttt tatatgatcg taaaatataa ttattttatc tttatattca
     6961 ttattttctg ttaaaaacgg ggttttctat cccctgctac accttatatc aacggtgggc
     7021 aaatcaacca taggatcttc ctccaacaat cacttaaaaa agtaggggat ctctccccca
     7081 cttatccgat catccctgtc acaaagggat tggattcctg ttctcgccca atcgttgtca
     7141 caggaccatg ccctgagtag actattgtct cctctggtaa ttccatgatc gtgtcatgga
     7201 tacttctcat gagcgtctga tgatcaccgc caggtaaatc cgttcggcca atcgatcctg
     7261 caaacaacac gtccccacta aacaccatct gtgggaaaat aaaagagagg ctccctggtg
     7321 aatggcctgg ggtgtgtgct accttcactt tctctcccaa cacagagatc gtttcgccac
     7381 catgcaacac tttatctgcc ggttgacagc ttatttcagg aataccagga aacatccccg
     7441 aaccatttag acgtgaatca gtcaaccact ctgtctccgc ctgatggatg gtaaccgaag
     7501 cccctgtcgc ttctcgtacc gcttccactc caccaatgtg atcaaagtgg gcgtgggtaa
     7561 gtaaaatctc ctttacggaa agttgtaatt ctgcgatcct ctttagcaaa gcatctggtt
     7621 cagtacctgg atcgatcacg atcccttctc ccccttgttt acggtacagc aaataacaat
     7681 tggtcatcac gtagcctaga gtgaagctct ctacttggat caaggatctg accacctttc
     7741 ctcatgctat ctccccccat tctacacgga aagcgcacgg gtttccaatg tggtcgtgtc
     7801 attcgcagga ttataaggag agtgtgtaga aaatgcaatc agatcattct gctagatggc
     7861 ttaaaattta gaaagtaata tcctgatgaa atcaagggat acctaggaac accctcccat
     7921 agattttatc aaagactccg tctggaaaaa tccgtctaat tgaggaggaa catctttgta
     7981 ctttcaccgt tttttttatg aacccttagc acacgcatcc tttctcgtgg gttgtaccca
     8041 ctcccaggaa gcattagtcg ttgatccagg tcgcgatata acgccctatc tagaattagc
     8101 ccatcgggaa ggaatgcaaa ttaccgctat tgctgaaact catatccatg cagacctact
     8161 ttcaggggca aaagagctag ccgaacgcac ccatgcttct ctgtatctct ctggagaagg
     8221 gggtgctgga gattatgcat gggcgcaaga tcttccccat cgtttcctac gagacaacga
     8281 tgagtttacc ataggaggat tacgtataaa ggcacttcat actcctggtc atactcctga
     8341 acacctttct tttctattaa cccaagagac agtccgtact ccccttggtt tatttacggg
     8401 tgatttctta tttgtcgggg atgcaggtcg tccagacctt ttggagaagg cgattggtgt
     8461 ccaaggaaat gccgctataa gtgccaaagc cctctatcac tcgatccagc ggatacgaag
     8521 ccttcctgat catcttcaga tatggccctc tcatggggcc ggtagtgcct gtggcaaagc
     8581 cctcggctct ttgcccatgt caactcttgg ctatgaaaaa caaacaagtt gggtttttca
     8641 agatcaggat atagcaagct ttctaaagaa aatccagaca ggacagccta cgccacctcc
     8701 ttatttctct cgtatgaaaa agtggaatcg ctcccatctc cctttattac gcgagcggcc
     8761 aaagcctgaa cgttttactg ctgaagacat acgacaatta gactttggca aggatggctt
     8821 ttacctcgta gatacacgtc ccgctggcga attccttcaa agtcatatta aaggctccct
     8881 ttgtcttcct cataatcgtt catttatcca atgggctggg tggtttttgg aggatgctcc
     8941 cccattagtc gtgatcgtgg acgaaaagcg acagaagcaa ttagaacgtg acctcgcgat
     9001 gattggattg gaccatattg caggaatcct ccccacaagt gaaattaccc gttttcaagc
     9061 gagtgaacta gagagggtta tagaagctga gcctagtgag attgcccaac gcgtcaacca
     9121 aggggatgtt acagtgattg acgtccgcaa tgactccgaa tgggaagcag gtcatcttcc
     9181 ccaggcacta cacattcctc ttactcagct cacttctcaa ttggatacac tttccaaaga
     9241 tcgccctctc cttctccaat gtaaagcggg tggccgttct gcaattgcct ccagccttct
     9301 tcaggcacaa ggttatgatg taattaacct ccggggtgga tgggatcggt ggatggaatg
     9361 taacctcccc acttgttctt cacctgcttc ttcctcttaa ttctcaagag atgccataca
     9421 ccaacaaaca cagcccctcc tatgatttgg gaggggctgt gtttgttagt tattgccacc
     9481 ccgaaactat gagatcggtg accccctgct acgatatacg gatgatcctc gcaaattaca
     9541 ttaagggatt ggagacgttt cagtgatatt tctgtgactc tcctatgtat atacggtttt
     9601 ctcttactta caaatccgtg tatactggga taacggagtt gttaataccc aggtctgtaa
     9661 atcaaaccat tatcgacgaa ttaactctct ctatagaaag gaggaaagtg ctatgacagt
     9721 cacatgtatt ctctgtgaag attcctttgt tcctacatcc atacaagcca agaagatccg
     9781 caagcatccc catcgcatct tcctctgtcc agcttgtcat gaacgtgtcg ccaaaaaagc
     9841 caaagaatct cctcacctaa tccaagtaaa accatctctg cctcatctct agctcttatc
     9901 ctctaatcca cagtcccatg cagcattata ctttggttct gtttcaatac tgcgaagtaa
     9961 tgattcggcc tgttctcgac catagggacg ggattcttca tctccatcct tctgccaact
    10021 tacccagtac ttgttcgctt ctactgcaat ggaaagctcc ttaacaccat gatcctcctg
    10081 taacatttgc tggaaaaagc ggaccgtctc ctcggcagaa cggtcctttg ggcgtgcatt
    10141 ccatactaaa cgaatctgta gccagttaaa taacgcttct tctaatcgca ctgcatactc
    10201 tccccttttt gcaatctacc tttttaaact aaccacaacc aggagaagca gaagcttctc
    10261 ctagaaaaag ctgaaccagc cactctcacc catttaagac gtagtcggtg gaccttcctg
    10321 ttccttccga tgattcgtcc ccatgcgaat ccgagcaatc gcaatcatca ccacggtgac
    10381 ggataagatc tcaatcatcg ggaacttcaa gaaaaagagt gcccaaaaga gaatacatcc
    10441 gattgccaag accacataaa ctacggcagc cttcaaaatt ggcaatcgac gagcaaaggc
    10501 cactttatag atgatactgg tcaataccag gatcaacaga tacgctagag ctggctcccc
    10561 tcgtaaccat tcattgattc cttccatctc atatcctcct ctctgccatc attggtagaa
    10621 cattttcaat gtgcgggtgt tccttctttc aactgatgta agtactgaat ctcctcagca
    10681 tattcctctt ctttttccac tggtgtttcc aggatgatcg gtatgccctc tagttgttca
    10741 caatggagga aacgggttaa cgcttctgcc ccaatctctc cctttccaat cttctcatgg
    10801 cgatccttgc gggattcgta tggagcttta ctatcattaa aatggatagc aattaagctt
    10861 tttaggtagc ctgtctcttc catcttctca atcaattcgt caaaggtagg caaattccat
    10921 gctcctgccg caaaaccatg gcaagtatcg aagcaaaagc cgattttttc cggataatcc
    10981 gtcgcttcac ggatcttgac gaggtcttca atcttcagac ccaattccgt cccttgtcca
    11041 gcggtatttt caagtaaaag tagcgtgtct ccatcataat ctgcgaggat ttcatttaag
    11101 gtttccacca ttctacgggt accctcttct tccccctcac cgacatgttt tccacaatgg
    11161 acgaccgcac ctatcgcacc ataggtttct gcaatatgaa gatcttcctt aatggaacgt
    11221 acggttacct catgaaggtc cacctttggt gtcgatagat tggtaatata gggtgtatga
    11281 gcgaccaaag tgattccctt ttcacggcaa aaggcaactc ccttttcagc gtccgcataa
    11341 tcaacctttt tcggacgtag tccacgcggg ttcttagtaa acacctgaaa agacgccgct
    11401 cctaactccg ctgcttgaaa actcgctttt gaaaatcctt tggctacgct aatatggcaa
    11461 cccaatttca tcctcttcac tcctcttaaa gaaagaagcg cctcactcgg gcgcttcttg
    11521 aatcatcgtc atcataccat tttgggcaga caagccgcaa ctgaatcaaa ccaaaggtgg
    11581 gaattattcc ccgcgattga gttcagtaaa cgcctgttcc actttatctg tgatgagtgc
    11641 atccacgcct aatccgatga gtcggcgcat ctctttcacc tgattgatag taaaggggcg
    11701 tactgggagg ttatactctc ggcatttagc taccatagat tctactaccg tcggccgata
    11761 tggatggata gaagtaacac cgactttacg ggcatattcc caaggctcaa atagatta
//
