LOCUS       NZ_LT629789            25554 bp    DNA     circular CON 13-MAY-2024
DEFINITION  Amycolatopsis keratiniphila strain FH 1893 chromosome I.
ACCESSION   NZ_LT629789
VERSION     NZ_LT629789.1
KEYWORDS    RefSeq.
SOURCE      Amycolatopsis keratiniphila
  ORGANISM  Amycolatopsis keratiniphila
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Amycolatopsis; Amycolatopsis japonica group.
REFERENCE   1
  AUTHORS   Varghese,N. and Submissions,S.
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2016) DOE - JOINT GENOME INSTITUTE, LBNL, 2800
            Mitchell Drive, Walnut Creek, CA 94598, 94598, USA
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_900105855.1-RS_2024_05_13
            Annotation Date                   :: 05/13/2024 02:01:53
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,886
            CDSs (total)                      :: 8,813
            Genes (coding)                    :: 8,742
            CDSs (with protein)               :: 8,742
            Genes (RNA)                       :: 73
            rRNAs                             :: 4, 4, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 4, 4 (5S, 16S, 23S)
            tRNAs                             :: 58
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 71
            CDSs (without protein)            :: 71
            Pseudo Genes (ambiguous residues) :: 0 of 71
            Pseudo Genes (frameshifted)       :: 26 of 71
            Pseudo Genes (incomplete)         :: 51 of 71
            Pseudo Genes (internal stop)      :: 1 of 71
            Pseudo Genes (multiple problems)  :: 6 of 71
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 18:07:53
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 8428923
            Orig. end                         :: 8454477
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            LT629789.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..25554
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="redox-cofactor"
                     /region_number="32"
                     /rules="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /tool="antismash"
     cand_cluster    1..25554
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(cds(PF04055 and (TIGR04085 or SPASM))
                     and (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /kind="single"
                     /product="redox-cofactor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..25554
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:15554](+)"
                     /cutoff="20000"
                     /detection_rule="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /neighbourhood="10000"
                     /product="redox-cofactor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..15554
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /neighbourhood="10000"
                     /product="redox-cofactor"
                     /protocluster_number="1"
     misc_feature    complement(14..29)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: medium, score: 20.94"
                     /tool="antismash"
     gene            317..1423
                     /locus_tag="BLU53_RS38700"
                     /old_locus_tag="SAMN04489733_7932"
     CDS             317..1423
                     /EC_number="1.1.99.36"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0051287 - NAD binding [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_ER (14-361). E-value: 1.9e-14.
                     Score: 45.4. Matches aSDomain:
                     nrpspksdomains_BLU53_RS38700_PKS_ER.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1040: alcohol dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020662084.1"
                     /locus_tag="BLU53_RS38700"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04489733_7932"
                     /product="NDMA-dependent alcohol dehydrogenase"
                     /protein_id="WP_072030250.1"
                     /sec_met_domain="ADH_N (E-value: 5.1e-29, bitscore: 99.3,
                     seeds: 66, tool: rule-based-clusters)"
                     /sec_met_domain="ADH_zinc_N (E-value: 1.4e-17, bitscore:
                     62.9, seeds: 86, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKTKAAVLWGQHEKWMVEEIDLDPPKAGEVLVKLTASGLCHSDEH
                     LVTGDLPFPYPLVGGHEGAGVVESVGPDVTEVAEGDHVVMTFLPACGRCSYCARGLGNL
                     CDAGAAVMLGPQLDNTYRFHARGEDVGQMCLLGTFSEYTVVPAASVVKIDAGIPLDKAA
                     LVGCGVTTGFGSAVRTGGVRAGDAVVVVGVGGIGVNAIQGARIAGARLIVAIDPVEFKR
                     TKALEFGATHTASSMDEAWNTVSELTRGQLADVCVLTTDVAEGAHITPALSLVGKRGRV
                     VVTAIGHPEETSITTSLIELTLYEKQLRGSLFGSSNGQHDVPRLLELYNDGLLKLDELI
                     TTEYSLEDVNQGYEDMRNGKNIRGLIRY"
     aSDomain        359..1399
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_BLU53_RS38700_PKS_ER.1"
                     /evalue="1.90E-14"
                     /label="BLU53_RS38700_PKS_ER.1"
                     /locus_tag="BLU53_RS38700"
                     /protein_end="361"
                     /protein_start="14"
                     /score="45.4"
                     /tool="antismash"
                     /translation="WMVEEIDLDPPKAGEVLVKLTASGLCHSDEHLVTGDLPFPYPLVG
                     GHEGAGVVESVGPDVTEVAEGDHVVMTFLPACGRCSYCARGLGNLCDAGAAVMLGPQLD
                     NTYRFHARGEDVGQMCLLGTFSEYTVVPAASVVKIDAGIPLDKAALVGCGVTTGFGSAV
                     RTGGVRAGDAVVVVGVGGIGVNAIQGARIAGARLIVAIDPVEFKRTKALEFGATHTASS
                     MDEAWNTVSELTRGQLADVCVLTTDVAEGAHITPALSLVGKRGRVVVTAIGHPEETSIT
                     TSLIELTLYEKQLRGSLFGSSNGQHDVPRLLELYNDGLLKLDELITTEYSLEDVNQGYE
                     DMRNGKN"
     gene            1475..2458
                     /locus_tag="BLU53_RS38705"
                     /old_locus_tag="SAMN04489733_7933"
     CDS             1475..2458
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020662083.1"
                     /locus_tag="BLU53_RS38705"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04489733_7933"
                     /product="R2-like ligand-binding oxidase"
                     /protein_id="WP_072030251.1"
                     /transl_table=11
                     /translation="MAIDRNIEHGKRTGFGSLSEGGLRMESFPMRLFRKGNKKFWNPED
                     IDFSQDAKDFAAMSPDEKRLASILAAQFMAGEESVTQDLQPFMTAMAAEGRLADEAYLT
                     QFTFEEAKHMQAFRLWFDAVGLSTDLHNFVEYSEPYTKIFTEELPKSLYALESDPSPAA
                     QIRASVTYNHVVEGCLALTGYFAWAKVCKSRNILPGMQQVVKYIGDDERRHMAWGTFTC
                     RRHVAADDRNWDVVDERMQELLQPALQLIVRLFDAFEGDTPFGINIDEMTDYGLDKVSR
                     RLESIESARGCPVEEIDEDYSPMQLEDKFAAEDEAAVARALTAVGS"
     gene            2521..3543
                     /locus_tag="BLU53_RS38710"
                     /old_locus_tag="SAMN04489733_7934"
     CDS             2521..3543
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0050660 - flavin adenine dinucleotide
                     binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1176: alkyl hydroperoxide reductase subunit"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020662082.1"
                     /locus_tag="BLU53_RS38710"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04489733_7934"
                     /product="NAD(P)/FAD-dependent oxidoreductase"
                     /protein_id="WP_072030252.1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 1e-18, bitscore:
                     66.6, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLQDTSAQEANTNVDLLFIGAGPVGLFGAYYAGFRGLSMAVVDAL
                     PEVGGQVQAIYPEKKIYDIAGLPGVPGQELIGNLVRQAAPFSPLYLLSQQVQRLERRDG
                     GWRARTSTGVVVDARAVVITSGVGAVTPRPIPAGEDFLGRGLCYFVPRLDVLDGKDVVV
                     VGGGDSAVDWALAALPRARSTTLVHRRRQFRAHEHSVQLLHQSACNVLVDANVTELRGQ
                     DWVESVAIQVAGEAEARQTKAQVVVAALGFLMDLGPIKDWGLELEGRAIRVDSKMRTNL
                     PDVFAAGDAATFDGKVKLIAVGFGEVATAVNNAAVSLDPQAGLAPGHSSDLTVPAQVGA
                     "
     gene            3587..3901
                     /gene="fdxA"
                     /locus_tag="BLU53_RS38715"
                     /old_locus_tag="SAMN04489733_7935"
     CDS             3587..3901
                     /GO_function="GO:0009055 - electron transfer activity
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="fdxA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020662081.1"
                     /locus_tag="BLU53_RS38715"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04489733_7935"
                     /product="ferredoxin"
                     /protein_id="WP_072031312.1"
                     /transl_table=11
                     /translation="MAFVIGEPCVDVKDMTCIEECPVDCIYEGERMLYIHPSECIDCAA
                     CEPVCPVEAIKPAQHVDDRWRPFQESAKAAFDVLGSPGGSTKVDPPIEDTEYVKNFEKN
                     "
     gene            3964..4590
                     /locus_tag="BLU53_RS38720"
                     /old_locus_tag="SAMN04489733_7936"
     CDS             3964..4590
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0016987 - sigma factor activity [Evidence
                     IEA]"
                     /GO_process="GO:0006352 - DNA-templated transcription
                     initiation [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1032: RNA
                     polymerase, sigma-24 subunit, ECF subfamily"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020662080.1"
                     /locus_tag="BLU53_RS38720"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04489733_7936"
                     /product="sigma-70 family RNA polymerase sigma factor"
                     /protein_id="WP_083715759.1"
                     /transl_table=11
                     /translation="MTSTVTLDCERTDETDMTDRVSFVSSETDPWSLVRASQKGDYRAF
                     GLLYSRFSADVFRFARGRLRDEHAAEDVTSETFLRALRNIGTVRYVGSSVRAWLLTIAR
                     NIILDHVKSGRFRHEVTVSEFSEQDQAVVFPEFSIFSQDCRDEIARQMFELSEDQRICL
                     RLRFFDGLSVSETAQVMRRKSSAVRALQHRAVRRLAELVDPVAVD"
     gene            4645..6144
                     /locus_tag="BLU53_RS38725"
                     /old_locus_tag="SAMN04489733_7937"
     CDS             4645..6144
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aldedh"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1017: aldehyde dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020662079.1"
                     /locus_tag="BLU53_RS38725"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04489733_7937"
                     /product="aldehyde dehydrogenase family protein"
                     /protein_id="WP_072030253.1"
                     /sec_met_domain="Aldedh (E-value: 4.3e-183, bitscore:
                     608.0, seeds: 89, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTMVSAEIPMVVRPFLENASASIVIGADRTTAAGGDQIPTTDPAT
                     GALLASIAAGGKADVDRAVEAAHKAFASWRRLSPAARGRVLLDVADAIDEYAEELATLE
                     TLDNGKPLTESTYLDVSLSAQIWRYFGGWTTKLGGQTLPVSPAVGDALVYTQREPLGVI
                     GAIVPWNFPLMIASWKVAPALAAGNTAVLKPSEFTSLSALRLTEVALEAGLPPGVLNVV
                     TGLGPEAGQALIDHPGVAKISFTGSTETGRRIVTASAGSLKKLTLELGGKSANIVFPDA
                     DVEAAVQGALNAIFLNQGQVCCAGSRLFVHRDIHDEVVAAVAAEAQGIQLGHGLDDDTQ
                     MGPLISARQLDRVEGFVGAGVRDGATLVCGGERPGGALAGGHFLKPTIFTDVRDEMSIA
                     ADEIFGPVLSVLKFDDEDEAVRRANSSVYGLAAGVWTNDLKRAHRVARELEAGTVWLNM
                     YNMIDPAAPFGGYKSSGYGRDLGEESLLGYTQTKSVWVGMD"
     gene            6206..6613
                     /locus_tag="BLU53_RS38730"
                     /old_locus_tag="SAMN04489733_7938"
     CDS             6206..6613
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020662078.1"
                     /locus_tag="BLU53_RS38730"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04489733_7938"
                     /product="SCP2 sterol-binding domain-containing protein"
                     /protein_id="WP_072030254.1"
                     /transl_table=11
                     /translation="MGAFKDESEVYKYIGGVFENGLADPDVGPKLKGSGVVLQITYTDP
                     DSVLTVDFPAGEVHTGASDVTPHVELFMTADTGNRFWLGKVNLSVAMAKGQVRAKGPVS
                     KILKLVPAAKSLFPAYESLLERDGRDDLLKA"
     gene            6666..8294
                     /locus_tag="BLU53_RS38735"
                     /old_locus_tag="SAMN04489733_7939"
     CDS             6666..8294
                     /NRPS_PKS="Domain: AMP-binding (20-437). E-value: 9.4e-90.
                     Score: 293.0. Matches aSDomain:
                     nrpspksdomains_BLU53_RS38735_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020662077.1"
                     /locus_tag="BLU53_RS38735"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04489733_7939"
                     /product="long-chain fatty acid--CoA ligase"
                     /protein_id="WP_072030255.1"
                     /sec_met_domain="AMP-binding (E-value: 2.9e-100, bitscore:
                     334.8, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRSTMQGTPLTVASILRHGVEVHGDRRVTTATDDGFRRTTYEQVG
                     NRCGQLANGLRRLGIAGDDRVATFQWNNQEHLEAYTAVPAMGAVLHTLNIRLSAEQIRF
                     IAGHAEDKVVIVDASLVPLLARVLPGLDTVKVVLVTGDGDLSPLESCGKAVLRYEDVLG
                     AESPEFAWTGADEDAGAAMCYTSGTTGDPKGVVYSHRSLYLHSMAACTGNGLGIAEQDR
                     ILPIVPMFHANAWGLPYAALMAGAELLMPDRFMQASALAGMVHAERPTLAGAVPTIWND
                     VLQHTEKEDGLDFSSLRLVVCGGSAVPRSLMEAFENRLGVTILQAWGMTETSPLASVAR
                     PAVSAGPDDAWRMRATQGRPVCGVEMRIVGDDGTPQPRNGQVVGELEVRGPWVTGSYYQ
                     VDDDARFHDGWLRTGDVGHLSAEGYLTLTDRMKDVIKSGGEWISSVELESALAGHPDVF
                     EAAVIAAPDERWQERPLAAVVLREGATVSAEELRSWLSGKLPRWWLPERWAFTDQIPRT
                     SVGKFDKKVLRGDYADGRLKVETLE"
     aSDomain        6726..7976
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_BLU53_RS38735_AMP-binding.1"
                     /evalue="9.40E-90"
                     /label="BLU53_RS38735_AMP-binding.1"
                     /locus_tag="BLU53_RS38735"
                     /protein_end="437"
                     /protein_start="20"
                     /score="293.0"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="EVHGDRRVTTATDDGFRRTTYEQVGNRCGQLANGLRRLGIAGDDR
                     VATFQWNNQEHLEAYTAVPAMGAVLHTLNIRLSAEQIRFIAGHAEDKVVIVDASLVPLL
                     ARVLPGLDTVKVVLVTGDGDLSPLESCGKAVLRYEDVLGAESPEFAWTGADEDAGAAMC
                     YTSGTTGDPKGVVYSHRSLYLHSMAACTGNGLGIAEQDRILPIVPMFHANAWGLPYAAL
                     MAGAELLMPDRFMQASALAGMVHAERPTLAGAVPTIWNDVLQHTEKEDGLDFSSLRLVV
                     CGGSAVPRSLMEAFENRLGVTILQAWGMTETSPLASVARPAVSAGPDDAWRMRATQGRP
                     VCGVEMRIVGDDGTPQPRNGQVVGELEVRGPWVTGSYYQVDDDARFHDGWLRTGDVGHL
                     SAEGYLTLTDRMKDVIKS"
     misc_feature    7047..7049
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     CDS_motif       7206..7262
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_BLU53_RS38735_0001"
                     /evalue="4.60E-07"
                     /label="NRPS-A_a3"
                     /locus_tag="BLU53_RS38735"
                     /protein_end="199"
                     /protein_start="180"
                     /score="22.3"
                     /tool="antismash"
                     /translation="AMCYTSGTTGDPKGVVYSH"
     gene            8349..9290
                     /locus_tag="BLU53_RS38740"
                     /old_locus_tag="SAMN04489733_7940"
     CDS             8349..9290
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF012235.4"
                     /locus_tag="BLU53_RS38740"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04489733_7940"
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="WP_072030256.1"
                     /transl_table=11
                     /translation="MESVPSTSKIEFDGVTTVLGDEPVLHRLRLSVPDGQVTVILGQPG
                     CGKTTLLRHLVGLLPPTGGSVRLDGHDVWSLNTAELASARGGIAAVVGGAQLSDTCLFS
                     SMNVYENVACVVRRTGAMDDEVRATTTQLMREFGLDAFAELFPEEVPAGARRRVVLVQA
                     LMSGMPLIVLDDVDTAFHPRYTSAFVRAIKSLNEKARATVLIATRDLNFAREVAHEVAI
                     LWNGKITSHGPPDVLLRNVRTEEELGRRYFRPDLTGSAQKDAMDGDLRDGRPVRRFRAI
                     KQDYAVWCVVVLLLLVIVFVLWSSAGTVFGGQ"
     misc_feature    9060..9062
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            9293..9610
                     /locus_tag="BLU53_RS38745"
                     /old_locus_tag="SAMN04489733_7941"
     CDS             9293..9610
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010315532.1"
                     /locus_tag="BLU53_RS38745"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04489733_7941"
                     /product="hypothetical protein"
                     /protein_id="WP_072030257.1"
                     /transl_table=11
                     /translation="MGDPYLRTVRTAELSALAHAITMVEDHADLNHRYQALIDDSHVVL
                     SSDQIRLTQARGLAKRLVVLVKAADTELQAELTKTQRDVIDAGLSQADALIRIIDSHGY
                     R"
     gene            9904..10011
                     /gene="mftA"
                     /locus_tag="BLU53_RS38750"
                     /old_locus_tag="SAMN04489733_7943"
     CDS             9904..10011
                     /GO_function="GO:0009055 - electron transfer activity
                     [Evidence IEA]"
                     /GO_process="GO:0140604 - mycofactocin biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="mftA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020658597.1"
                     /locus_tag="BLU53_RS38750"
                     /note="Mycofactocin is a small molecule electron carrier
                     derived from the final two amino acids, Val-Tyr, of MftA,
                     the mycofactocin precursor. It plays a role in redox
                     homeostasis and the metabolism of alcohols and aldehydes in
                     Actinobacteria, including Mycobacterium tuberculosis;
                     Derived by automated computational analysis using gene
                     prediction method: Protein Homology."
                     /old_locus_tag="SAMN04489733_7943"
                     /product="mycofactocin precursor MftA"
                     /protein_id="WP_144024214.1"
                     /transl_table=11
                     /translation="MAENTVEQPAAGNDLVVAEDLLVEEVSIDGMCGVY"
     gene            10001..10291
                     /gene="mftB"
                     /locus_tag="BLU53_RS38755"
                     /old_locus_tag="SAMN04489733_7944"
     CDS             10001..10291
                     /GO_process="GO:0140604 - mycofactocin biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="mftB"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: Mycofactocin_RRE"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009076821.1"
                     /locus_tag="BLU53_RS38755"
                     /note="MftB, a small protein, is a peptide chaperone that
                     assists the radical SAM enzyme MftC in performing two
                     modifications to the C-terminal Val-Tyr dipeptide of the
                     mycofactocin precursor peptide, MftA. MftB's role is
                     analogous to the role of PqqD in the biosynthesis of PQQ, a
                     cofactor that derives entirely from a Tyr and a Glu in the
                     precursor PqqA.; MftB, a small protein, is a peptide
                     chaperone that assists the radical SAM enzyme MftC in
                     performing two modifications to the C-terminal Val-Tyr
                     dipeptide of the mycofactocin precursor peptide, MftA.
                     MftB's role is analogous to the role of PqqD in the
                     biosynthesis of PQQ, a cofactor that derives entirely from
                     a Tyr and a Glu in the precursor PqqA; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /old_locus_tag="SAMN04489733_7944"
                     /product="mycofactocin biosynthesis chaperone MftB"
                     /protein_id="WP_072030259.1"
                     /sec_met_domain="Mycofactocin_RRE (E-value: 3.5e-28,
                     bitscore: 96.7, seeds: 14, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTDAVAPFDLDSAWDLDERVAIRPERFGALLYHFGTRRLSFLKS
                     TALLAVVRALAEHPTARAACVGAGVDSPELPRYRAALAALAASHMIQPRSV"
     aSDomain        10034..10273
                     /aSDomain="Mycofactocin_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="Stand-alone RRE protein in a mycofactocin
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_BLU53_RS38755_Mycofactocin_RRE.1"
                     /evalue="1.10E-30"
                     /identifier="RREFam016.1"
                     /label="BLU53_RS38755"
                     /locus_tag="BLU53_RS38755"
                     /protein_end="91"
                     /protein_start="11"
                     /score="96.7"
                     /tool="antismash"
                     /translation="DSAWDLDERVAIRPERFGALLYHFGTRRLSFLKSTALLAVVRALA
                     EHPTARAACVGAGVDSPELPRYRAALAALAASHMI"
     gene            10291..11469
                     /gene="mftC"
                     /locus_tag="BLU53_RS38760"
                     /old_locus_tag="SAMN04489733_7945"
     CDS             10291..11469
                     /EC_number="1.3.98.7"
                     /EC_number="4.1.99.26"
                     /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /GO_process="GO:0031179 - peptide modification [Evidence
                     IEA]"
                     /GO_process="GO:0140604 - mycofactocin biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="mftC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: PF04055"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: TIGR04085"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: SPASM"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) QueE"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017983863.1"
                     /locus_tag="BLU53_RS38760"
                     /note="MftC is a radical SAM/SPASM enzyme that catalyzes
                     the first two steps in biosynthesis of the electron carrier
                     mycofactocin from the terminal Val-Tyr dipeptide of the
                     precursor peptide MftA.; MftC is a radical SAM/SPASM enzyme
                     that catalyzes the first two steps in biosynthesis of the
                     electron carrier mycofactocin from the terminal Val-Tyr
                     dipeptide of the precursor peptide MftA; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology."
                     /old_locus_tag="SAMN04489733_7945"
                     /product="mycofactocin radical SAM maturase"
                     /protein_id="WP_072030260.1"
                     /sec_met_domain="PF04055 (E-value: 2.6e-23, bitscore: 82.2,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 8.8e-06, bitscore: 25.0,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="QueE (E-value: 3.5e-08, bitscore: 32.2,
                     seeds: 32, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 3.4e-14, bitscore:
                     52.0, seeds: 281, tool: rule-based-clusters)"
                     /sec_met_domain="SPASM (E-value: 1.7e-05, bitscore: 24.2,
                     seeds: 166, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSLVDEFQYGLDAPICLTWELTYACNLSCVHCLSSSGRRDPRELS
                     TAECKALIDEFERMQVFYVNIGGGEPTVRADFWELVDYATEHHVGVKFSTNGVKITEAV
                     AERLAASDYVDVQISLDGATAEVNDHVRGTGSYATAIRAMENLAAAGFANFKISVVVTR
                     QNVSQLDDFKTIADRYGAQLRITRLRPSGRGADVWDELHPTAAQQRELYDWLVAHGENV
                     LTGDSFFHLAGYGDGGLPGLNLCGAGRVVCLVDPVGDVYACPFAIHDTFLAGNVRDGGF
                     TRVWRESELFAELRNPQGGGACSSCSAFDACRGGCMAAKFFTGLPLDGPDPECVRGHGE
                     LALAGVAAGSVPKPSLDHSHRRRPVPVSIGMRRPPDRACDENPLAGFTPPGR"
     gene            11472..12161
                     /gene="mftE"
                     /locus_tag="BLU53_RS38765"
                     /old_locus_tag="SAMN04489733_7946"
     CDS             11472..12161
                     /GO_process="GO:0140604 - mycofactocin biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="mftE"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009076817.1"
                     /locus_tag="BLU53_RS38765"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04489733_7946"
                     /product="mycofactocin biosynthesis peptidyl-dipeptidase
                     MftE"
                     /protein_id="WP_072030261.1"
                     /transl_table=11
                     /translation="MRLADLAWPDIAERAAGGAILAVPVGATEQHGPHLPLTTDTDIAV
                     ALCERLAVGRQDVLVAPPVAYGSSGEHAGFAGTVSIGQAATELLLVELGRSASETFQRL
                     LFVSAHGGNSGPVARAVARLRAESRDAEVFQPRWQGDPHAGRPETALQLVLRPESVRME
                     RADAGDCRPLVELLPLLCESGVKAVSGNGVLGDPTSATAREGELLLAELTAALERQVAA
                     WHPMVTR"
     gene            12158..12952
                     /locus_tag="BLU53_RS38770"
                     /old_locus_tag="SAMN04489733_7947"
     CDS             12158..12952
                     /NRPS_PKS="Domain: PKS_KR (4-180). E-value: 9.5e-12. Score:
                     37.1. Matches aSDomain:
                     nrpspksdomains_BLU53_RS38770_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020658593.1"
                     /locus_tag="BLU53_RS38770"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04489733_7947"
                     /product="mycofactocin-coupled SDR family oxidoreductase"
                     /protein_id="WP_072030262.1"
                     /transl_table=11
                     /translation="MSPRVAVVTGAARGIGAGTVLRLARHGYAVLAVDRAANDPDLPYT
                     MGTAAELSVVVENAREHSADIAAYIADVRDPVAVLCAVTEAENRWGGIDVAIAAAGVVA
                     GGVPQWETSPGQERAVLEVNLNGVLHLARAAVPAMLRRPRPRSGRFLAVASAAATRGLP
                     MLAAYCAAKAGVTGLIRALGVELGDTGVTANAVSPGSTGTPILAESARLYGLPGVAAFA
                     EQQPMRRLLDPAEIAAVLAFLAGPESCAMTGAVVPVDGGLAL"
     aSDomain        12170..12697
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_BLU53_RS38770_PKS_KR.1"
                     /evalue="9.50E-12"
                     /label="BLU53_RS38770_PKS_KR.1"
                     /locus_tag="BLU53_RS38770"
                     /protein_end="180"
                     /protein_start="4"
                     /score="37.1"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="VAVVTGAARGIGAGTVLRLARHGYAVLAVDRAANDPDLPYTMGTA
                     AELSVVVENAREHSADIAAYIADVRDPVAVLCAVTEAENRWGGIDVAIAAAGVVAGGVP
                     QWETSPGQERAVLEVNLNGVLHLARAAVPAMLRRPRPRSGRFLAVASAAATRGLPMLAA
                     YCAAKAGVTGLIR"
     gene            12949..14373
                     /gene="mftF"
                     /locus_tag="BLU53_RS38775"
                     /old_locus_tag="SAMN04489733_7948"
     CDS             12949..14373
                     /GO_process="GO:0140604 - mycofactocin biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="mftF"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020658592.1"
                     /locus_tag="BLU53_RS38775"
                     /note="Members of this protein family, MftF, are
                     glycosyltransferases, members of PF00535 (glycosyl
                     transferase family 2). The encoding gene is found as part
                     of the mycofactocin cassette, in Mycobacterium
                     tuberculosis, many other Actinobacteria, and occasional
                     members of other lineages. Mycofactocin itself, a putative
                     redox carrier, is a heavily modified derivative of the
                     C-terminal Val-Tyr dipeptide of the mycofactocin precursor
                     MftA (TIGR03969); Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04489733_7948"
                     /product="mycofactocin biosynthesis glycosyltransferase
                     MftF"
                     /protein_id="WP_072030263.1"
                     /sec_met_domain="Glycos_transf_2 (E-value: 1.2e-21,
                     bitscore: 76.4, seeds: 256, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKSTPLPFGFRITLDREVRQLSGGLWFGGSPARVLRLTEAGQKAW
                     QQLEDGPVTSAAAGTLARRLTDAGMATPVPPEPEGAPDVTVVIPAHDRVDLLERCLSGM
                     DDVHPVLVVDDASEDAAAVAAICAAYGAKLVRRDVNGGPGAARNTALEQVTTELVAFLD
                     SDCVPTKGWIDRLAAHFADPLLAAIAPRVRGLAPDSWAGRYTRATGSLDLGDRSARVAP
                     GTRTSYVPTAALVVRRSTLVEVGAFDPRLRVGEDVDLIWRLHKADHRIRYAADVHVDHH
                     EPTTWHGVLGRRARYGTSAAPLALRHPDALAHLALHPWSILTVAALLARRPLLAATAFG
                     GSVASMVDQLHANDVPQAGAVRVMATAAGQTWLGCGRYATQFAAPVLAALMVPGGRRRW
                     GRRAALASLLLGPPLAGWVKRRPALDPVRYTVAAVADDIAYGSGVWAGCLTHRTAAPLR
                     PAVVRRPLRFDLKGKQ"
     gene            14370..15554
                     /gene="mftD"
                     /locus_tag="BLU53_RS38780"
                     /old_locus_tag="SAMN04489733_7949"
     CDS             14370..15554
                     /EC_number="1.4.3.26"
                     /GO_process="GO:0140604 - mycofactocin biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="mftD"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: TIGR03966"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019819588.1"
                     /locus_tag="BLU53_RS38780"
                     /note="MftD, an enzyme found in the mycofactocin
                     biosynthesis locus, performs an oxidative deamination of
                     3-amino-5-[(p-hydroxyphenyl)methyl]-4,
                     4-dimethyl-2-pyrrolidinone (AHDP). The resulting compound,
                     now called pre-mycofactocin (PMFT), is a biologically
                     active redox cofactor that can oxidize the non-exchangeable
                     NADH of TIGR03971 family SDR-type oxidoreductases.; MftD,
                     an enzyme found in the mycofactocin biosynthesis locus,
                     performs an oxidative deamination of
                     3-amino-5-[(p-hydroxyphenyl)methyl]-4,
                     4-dimethyl-2-pyrrolidinone (AHDP). The resulting compound,
                     now called pre-mycofactocin (PMFT), is a biologically
                     active redox cofactor that can oxidize the non-exchangeable
                     NADH of TIGR03971 family SDR-type oxidoreductases.; MftD,
                     an enzyme found in the mycofactocin biosynthesis locus,
                     performs an oxidative deamination of
                     3-amino-5-[(p-hydroxyphenyl)methyl]-4,
                     4-dimethyl-2-pyrrolidinone (AHDP). The resulting compound,
                     now called pre-mycofactocin (PMFT), is a biologically
                     active redox cofactor that can oxidize the non-exchangeable
                     NADH of TIGR03971 family SDR-type oxidoreductases.; MftD,
                     an enzyme found in the mycofactocin biosynthesis locus,
                     performs an oxidative deamination of
                     3-amino-5-[(p-hydroxyphenyl)methyl]-4,
                     4-dimethyl-2-pyrrolidinone (AHDP). The resulting compound,
                     now called pre-mycofactocin (PMFT), is a biologically
                     active redox cofactor that can oxidize the non-exchangeable
                     NADH of TIGR03971 family SDR-type oxidoreductases; Derived
                     by automated computational analysis using gene prediction
                     method: Protein Homology."
                     /old_locus_tag="SAMN04489733_7949"
                     /product="pre-mycofactocin synthase MftD"
                     /protein_id="WP_072030264.1"
                     /sec_met_domain="TIGR03966 (E-value: 3.9e-211, bitscore:
                     699.5, seeds: 10, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSNTWFESIAEAQRRAKKRLPGSVYSALIAGSEKGLTLSDNLAAF
                     DELRYAPRTAGLPGERELGTHVLGRDVALPVLISPTGVQAVHPDGEVAVARAAAARGTS
                     MGLSSFGSKSVEDVVAANPNTYFQVYWTGSRDDILRRLERARAAGAVGIILTLDWSFSH
                     SRDWGSPHIPERLTFRELLRFAPEGLAHPRWLLDFAKTRRLPDLSVPNMASPGDTAPTF
                     FGAYGQWMQTPPPSWDDVSWLRTQWDGPFLLKGVIRVDEARRAVDAGVSAISVSNHGGN
                     NLDGTPATIRALPAIADAVGSQVEVLLDGGIRRGGDVVKALALGARAVLIGRAYLWGLA
                     AGGQAGVENVLDVLRNGIDSTLLGLGKRSIHELCRDDLVVPQGFAVDLGTVART"
     misc_feature    15246..15248
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            15832..16098
                     /locus_tag="BLU53_RS38785"
                     /old_locus_tag="SAMN04489733_7950"
     CDS             15832..16098
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019484296.1"
                     /locus_tag="BLU53_RS38785"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04489733_7950"
                     /product="metal-sensitive transcriptional regulator"
                     /protein_id="WP_228708417.1"
                     /transl_table=11
                     /translation="MELAGEELRAVLNRLRRAQGQIAGVIRMIEEGRDCEAVVTQLAAV
                     SRALDKAGFAIIATGLQRCIAEGQSADSEQMKQRLEKLFLSLA"
     gene            complement(16105..16911)
                     /locus_tag="BLU53_RS38790"
                     /old_locus_tag="SAMN04489733_7951"
     CDS             complement(16105..16911)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015100075.1"
                     /locus_tag="BLU53_RS38790"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04489733_7951"
                     /product="sulfite exporter TauE/SafE family protein"
                     /protein_id="WP_072030266.1"
                     /transl_table=11
                     /translation="MSGLLFALAAGAVVGLALGALGGGGGVLAVPALVYLLGLPPAAAA
                     TASLLIVTATSLTALARQSADVAWRTGLLFGLAGLPTAIAAGFAADHIPAPALTAAFAV
                     LATIAATVMLRDTRAPTHDPGHDRNKSRGEGSVATMTRTSATKAAGAGAGLGAVTGLLG
                     VGGGFLAVPALVTTLSLRMRTAVATSLLVILLNSAVALSTRLVTTPTSLNWAVVAPFAA
                     TAILGAWDGKRLAAKLSARTLQRVFAFVLLAVAAFMLVEAAIRTFR"
     gene            complement(16908..17285)
                     /locus_tag="BLU53_RS38795"
                     /old_locus_tag="SAMN04489733_7952"
     CDS             complement(16908..17285)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1163: rhodanese domain-containing protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020642711.1"
                     /locus_tag="BLU53_RS38795"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04489733_7952"
                     /product="rhodanese-like domain-containing protein"
                     /protein_id="WP_083715760.1"
                     /transl_table=11
                     /translation="MSTPSPHDLFADSSGAVDPAVVHQAVDAGEAVLLDVRETDEYTAG
                     HAPGAVHLPLSRLRDGAEPPVDIGQRPVFAICRSGARSAIATGILAERGHTVSNVVGGM
                     HAWHQAGLPVVDELGGNGTVA"
     gene            complement(17282..18016)
                     /locus_tag="BLU53_RS38800"
                     /old_locus_tag="SAMN04489733_7953"
     CDS             complement(17282..18016)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1163: rhodanese domain-containing protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012790.4"
                     /locus_tag="BLU53_RS38800"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04489733_7953"
                     /product="rhodanese-like domain-containing protein"
                     /protein_id="WP_197684736.1"
                     /transl_table=11
                     /translation="MLAGLDDVPAYYTHMGPINAAGPAPVDLTPPRRADAAEIAERLAA
                     GEWVVDLRSRIAFADGHVAGSVNIEGDGSLATYLAWLMPWNKPVTLLGESPEQVAAAQR
                     ELVRVGVNRPAAAGVGTPEDWVLDGDKPSSFPRAGFAELAAALTDGQRPVVLDVRRDSE
                     REQSRIEDTVHIPIHSLPDRVHEVPPGRVWVHCASGLRAAIGASLLDAAGRDVVAIDDD
                     YSAAGDIPGLTVATGEEERRTR"
     misc_feature    complement(18147..18162)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: medium, score: 16.52"
                     /tool="antismash"
     gene            18148..19431
                     /locus_tag="BLU53_RS38805"
                     /old_locus_tag="SAMN04489733_7954"
     CDS             18148..19431
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1130: transposase"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008258297.1"
                     /locus_tag="BLU53_RS38805"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04489733_7954"
                     /product="IS256 family transposase"
                     /protein_id="WP_072030206.1"
                     /transl_table=11
                     /translation="MTENTSDQAAGPAAGEALARVFPPETLDALVKDAYANGGALGAQE
                     LLNEMTKAVLERALDAEMTHHLGYEKGDPAGNGSGNSRNGRSPKTVSTTNGPVELAVPR
                     DRNGSFEPAIVPKRARRLGNIDEAILSLYSRGMTTRDIESHLREVYGVNVSRELISNVT
                     EVVTDEIALWQSRPLDEMYPILYVDGLRLRIKDKGVVTSKVAYLAIGVDMEGRKHALGL
                     WIADTEAAKFWAKVVTDLRNRGVKDILIACCDGLTGLPDAIRGAFPDTVVQTCVVHVIR
                     NAMRFISYGDRKKVAAAMRDIYTAPTLEAAEIALTQFDKNFGTQYPAAIQVWRHAWNDF
                     TPFLDYPPELRRIVYTTNLIENINFQLRKITKNRGHFDSDTAATKLLYLGLRNITSNRG
                     GPSGTGTRGWKQALNTLAALFPDRLPLH"
     misc_feature    18583..18585
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(19457..20089)
                     /locus_tag="BLU53_RS38810"
                     /old_locus_tag="SAMN04489733_7955"
     CDS             complement(19457..20089)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1170: metallo-beta-lactamase family protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012955.4"
                     /locus_tag="BLU53_RS38810"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04489733_7955"
                     /product="MBL fold metallo-hydrolase"
                     /protein_id="WP_144024083.1"
                     /transl_table=11
                     /translation="MYFIETIKVEGLGNRHYLAGSESVAVAVDPPRDVDRVLAAAAGSG
                     VRIGWVVETHVHNDYVSGGLDLARLTGARYMVPAGARVAFDHSTVSDGDVVELAEGLAL
                     RAVATPGHTPHHTSYVLVDSGRDVAVFTGGSLLIGTVGRPDLVDPRLTESLARAQHASA
                     HRLAAELDDAVPVLPTHGFGSFCSSSQAQGESTTIGAEKQDSVMISV"
     misc_feature    complement(20109..20118)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 14.85"
                     /tool="antismash"
     misc_feature    20115..20130
                     /note="TFBS match to CsoR, Copper-responsive repressor,
                     confidence: weak, score: 22.0"
                     /tool="antismash"
     gene            20274..20648
                     /locus_tag="BLU53_RS38815"
                     /old_locus_tag="SAMN04489733_7956"
     CDS             20274..20648
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020658985.1"
                     /locus_tag="BLU53_RS38815"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04489733_7956"
                     /product="DUF302 domain-containing protein"
                     /protein_id="WP_228708138.1"
                     /transl_table=11
                     /translation="MNAGFADTVEAVRRALAEQGFGVLTEIDVTATLKAKLDHDMEPYL
                     ILGACNPPLAHRALDVDRTIGLLLPCNVVVRADGDSTLVQALDPATMVELTGLSDLALV
                     AADATRRLDAALSGLDVITA"
     gene            20663..21574
                     /locus_tag="BLU53_RS38820"
                     /old_locus_tag="SAMN04489733_7957"
     CDS             20663..21574
                     /GO_function="GO:0019104 - DNA N-glycosylase activity
                     [Evidence IEA]"
                     /GO_process="GO:0036297 - interstrand cross-link repair
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF017984.4"
                     /locus_tag="BLU53_RS38820"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04489733_7957"
                     /product="crosslink repair DNA glycosylase YcaQ family
                     protein"
                     /protein_id="WP_084798711.1"
                     /transl_table=11
                     /translation="MDVSLAQALAWRLERHFLVTGARSITEVVRRLGAVPAWSGDPGLA
                     MGRRLARPSSDAVADALGDGDLIRTYAFRGATHLLAADDAGVYLAVRCANRQWELPSWQ
                     AHYNLSPQDWLALRESVRDVVAHGPVRHSKLAEKVASHPRFRHLQAALSHPSHTLLKPL
                     AWQGDLCFGPVQDGQPTFQSPASSPRWTGLPDLHEAGRRAVLAYLAAYGPATRDNLHYW
                     LVAGLSAGRRRLDGWVGDLIQDHVAEIQVDGSRMLHLREHLASLTAAPKPEGVILLPGY
                     DQWVLGPGTADDHIVPARAARP"
     misc_feature    complement(21589..21599)
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 18.94"
                     /tool="antismash"
     misc_feature    21852..21866
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 18.12"
                     /tool="antismash"
     misc_feature    complement(22221..22235)
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 18.98"
                     /tool="antismash"
     gene            23061..23261
                     /locus_tag="BLU53_RS46195"
     CDS             23061..23261
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012905.4"
                     /locus_tag="BLU53_RS46195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="HAD family hydrolase"
                     /protein_id="WP_072030268.1"
                     /transl_table=11
                     /translation="MAELEEAGYTVAVFIDGNPAGILELSDRLRPGAASTIRRLTDLTG
                     TEPALLTGDNRRAATRLAAEV"
     gene            23310..23483
                     /locus_tag="BLU53_RS46200"
     CDS             23310..23483
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="BLU53_RS46200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_323807868.1"
                     /transl_table=11
                     /translation="MRELESRGANVVLVGDGVNDAPARHRRTADERHTRTGTVGVLPNA
                     TAPSRLPSAFTP"
     gene            complement(23639..24916)
                     /locus_tag="BLU53_RS38830"
                     /old_locus_tag="SAMN04489733_7960"
     CDS             complement(23639..24916)
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1106: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF024742.4"
                     /locus_tag="BLU53_RS38830"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04489733_7960"
                     /product="MFS transporter"
                     /protein_id="WP_072030269.1"
                     /transl_table=11
                     /translation="MSHNLTDIDVRAVQRRTITILLGTQIIFAVVMAMASPVAALLVQD
                     FTHSSTLAGIAQAATIAGGVLAAVPLASVTVRGGRRIGVTTGYLTAATGSALVVAGGIV
                     EFFPLVLLGTTLAGAAAAAGLQARFAATDLAEPGERGRAIGTVVWASTFGGVAGPLLAG
                     PSDDVARAAGLPPFTGPFLVIGIGLLVAAGAAHIWLRPDPLLVARARTADDTKLAQANR
                     SRLRPTLRMLARTPEARRAVIAVAVVHAVMVSGMNMASLHLHHGGESLRVVGAAISAHL
                     AGMYFLSPLFGWLVDRFGARKVLGLGLGLLLTACGILQLTHDNSVTVMIIGLVVLGLGW
                     SAGFVAGSALLTGSVQESDRPHAQGVSDLLMQLAAALAAFPAGAVLDAWGYPWLARIAA
                     VPVLLVVIQQVLLYRRSSRTPTAASK"
ORIGIN
        1 gggctgtgga tcgccgacca aatcgtccag tcgctcgacg gacggatccg gttccgctca
       61 cgttcgggcg gtggtctggc cgtcttcctc gaagtgccag tcggctgagc tcctctcacc
      121 atccgggccg agtagttctc cttcttgacg tcattcgcgt cttttcagcc tgcgtgggcg
      181 catttcccga ctacgtggcc tatgcggtcg gtggagttgg cacgcgcggg ccaccactgg
      241 cgcgcgtgac cggtgtgaat cgtgtcgggt cttgtgatga tgacctgagc ccttcaccta
      301 cgaggagttg acgtcaatga agacgaaggc cgcggtcctt tggggacagc acgaaaagtg
      361 gatggttgag gaaatagacc tggatccacc gaaggccggc gaggtcttgg tcaagctgac
      421 cgccagcggg ctgtgccact ccgacgagca cctcgtcacc ggagacctgc ccttccccta
      481 ccccctggtc ggcggccacg aaggggccgg tgtggtcgag tccgtcggcc cagacgtcac
      541 ggaagtcgcc gagggcgacc acgtcgtcat gactttcctg cccgcctgcg gccggtgctc
      601 gtactgtgcg cgaggtttgg gcaatctgtg tgacgccggc gccgccgtga tgctcggccc
      661 gcagctggac aacacctacc gcttccacgc tcgaggcgag gacgtcggcc agatgtgcct
      721 gctcggcacg ttctcggagt acaccgtcgt tccggcggcg tcggtcgtga agatcgacgc
      781 cggaattccg ctggacaagg ccgccctcgt cggctgtggt gtcacgaccg gcttcggtag
      841 cgccgtgcgg accggaggag tacgagccgg tgacgcggtg gtcgtcgtcg gggtcggcgg
      901 gatcggtgtc aacgcgatcc agggcgcccg gatcgcaggt gcccggctca tcgtcgcgat
      961 cgacccggtc gagttcaagc gtacgaaggc gctcgagttc ggggccactc acacggcctc
     1021 gtcgatggac gaggcgtgga acaccgtcag cgagttgacc cgtggccagt tggccgacgt
     1081 gtgcgtccta accacggacg tcgctgaagg cgcgcacatc acgcccgcgc tttcactcgt
     1141 gggcaagcgc ggccgggtcg ttgtcaccgc catcggtcat cccgaggaaa cgtcgatcac
     1201 gaccagcctc atcgagttga cgctgtacga aaagcagctc cgcggttccc ttttcggttc
     1261 gtccaacggt cagcacgacg tgccacgtct gctcgagctc tacaacgacg ggctgctgaa
     1321 gctcgacgag ctcatcacca ccgagtactc cctggaagac gtcaaccagg gttacgagga
     1381 catgcgcaac ggcaagaaca tccgcggtct tatccgctac tagtccgctt gggccgaccg
     1441 taacagcttc gattcgtgat gtgaggacag tttcatggct atcgaccgca acatcgagca
     1501 cggcaagcgc acgggcttcg gcagcctgag cgagggtggt ctccgcatgg agtcgttccc
     1561 gatgcgcttg ttccgtaagg gaaacaagaa gttctggaat cccgaagaca tcgacttctc
     1621 ccaagacgcc aaggacttcg cggcgatgag cccggacgag aagcggctcg cgtcgatcct
     1681 ggccgcccag ttcatggccg gtgaggagtc cgtgacgcag gacctgcagc ccttcatgac
     1741 ggcgatggcc gctgaaggca ggctggcgga cgaggcttac ctgacgcagt tcaccttcga
     1801 agaagccaag cacatgcagg cttttcgcct gtggttcgac gcagtcggtc tcagtaccga
     1861 tctccacaac ttcgtcgagt acagcgagcc gtacacgaag atcttcaccg aagagctgcc
     1921 caaatcgctg tacgcgctgg agagcgaccc gtcgcctgcc gcccagatcc gcgcatccgt
     1981 gacctacaac catgtggtcg aaggctgtct cgccctcacc ggctacttcg cgtgggccaa
     2041 ggtgtgcaag agccggaaca ttctgcccgg catgcagcag gtcgtgaagt acatcggcga
     2101 cgacgagcgg cgtcacatgg catggggcac cttcacctgt cggcgccacg tcgccgccga
     2161 cgaccgcaac tgggacgtcg tcgacgagcg gatgcaggag ctgctccagc ctgcactgca
     2221 gctgatcgtg cggctgttcg acgctttcga gggcgacacg ccgttcggca tcaacatcga
     2281 cgagatgacc gactacgggc tggacaaggt cagccgcagg ctcgagtcga tcgaaagcgc
     2341 aaggggatgt ccggtcgagg aaatcgacga ggactactcg ccgatgcagc tcgaggacaa
     2401 gttcgccgcg gaagacgaag cggcggttgc gcgggcgctg acggcagtcg gctcctgacc
     2461 cgtcgagttc tcaccggcaa ccaggtcaac gcagacctcg aacccaagga aatcatcgac
     2521 atgcttcagg acacgtctgc ccaagaagcg aacacgaacg tcgacctgct cttcatcggg
     2581 gccgggccgg taggtctctt cggcgcgtac tacgcaggat tccgcggcct gagcatggcg
     2641 gtggtcgatg ctcttcccga ggtcggaggc caggtccagg cgatctaccc agagaagaag
     2701 atctacgaca tcgccggcct gccgggcgtg ccggggcagg agctcatcgg caacctcgtc
     2761 cggcaggccg cgccgttctc cccgctgtac ctgctctcac agcaggtaca gcggctcgag
     2821 cgtcgtgacg gcgggtggcg cgccaggact tcgaccggcg tggtggtcga cgcccgcgcg
     2881 gtcgtgatca cctctggcgt cggagcggtc accccgcggc ccatccctgc cggcgaggac
     2941 ttcctcggcc gcgggctgtg ctatttcgta ccgcggctgg atgtgctcga cggcaaggac
     3001 gtcgtggtgg tcggcggcgg ggactccgcg gtcgactggg cactggccgc cctgccgcga
     3061 gcgcggtcga ccacgctcgt gcaccgccga cggcagttcc gagcgcacga gcactcggtc
     3121 cagctgctcc accagtccgc ctgcaacgtg ctggtcgacg ccaacgtgac cgaactgcgc
     3181 gggcaggact gggtggagag cgtcgccatc caggtggcag gggaagccga ggcccgtcag
     3241 acgaaggcac aggtcgtcgt cgctgcgctc ggtttcctga tggacctcgg cccgatcaag
     3301 gactgggggc tcgagctcga gggccgcgcg atccgagtcg acagcaagat gcggacgaac
     3361 ctgcccgatg tcttcgcggc gggcgacgcc gcgaccttcg acggcaaggt caagctcatc
     3421 gccgtcggct tcggcgaggt cgcgaccgcg gtgaacaacg cggccgtatc gctcgatccg
     3481 caggcgggcc tcgcaccggg gcactccagc gacttgacgg ttcccgcgca agtcggcgcc
     3541 tgaacaacac cgacattcgt cgaacgaccc tgaggaggtg gaactgatgg ctttcgtcat
     3601 cggagaaccg tgcgtggacg tgaaagacat gacctgcatc gaggaatgcc cggtcgactg
     3661 catctacgag ggcgagcgca tgctctacat tcatccctcc gaatgcatcg actgcgccgc
     3721 ctgcgaaccg gtctgtccgg tcgaggccat caaaccggcc cagcacgtcg acgaccgctg
     3781 gcgccccttt caggaatctg cgaaggcggc gttcgacgtg ctcggcagtc cgggtgggtc
     3841 caccaaagtc gaccccccga tcgaggacac ggagtacgtg aagaacttcg agaagaacta
     3901 gccgcgacac tgcgcgcttc aggccggttt ctgggggcga gcggggtcac aaaggagttc
     3961 cagatgacgt caacggtgac gcttgactgc gaacgtacgg atgagactga catgactgat
     4021 cgtgtctcgt tcgtatcttc cgaaacggat ccatggtcgt tggtccgtgc ctcccagaag
     4081 ggcgactacc gggcgttcgg cttgttgtac agccgttttt cggcagatgt cttccgcttc
     4141 gcgcgagggc ggctgcgcga cgaacacgcg gccgaagatg tgaccagcga gacattcctg
     4201 cgcgcgctcc gcaatatcgg cactgtgagg tacgtgggat ctagcgtccg agcatggttg
     4261 ttgacgatag ccaggaacat catcttggat cacgtgaagt cgggacgatt ccggcatgaa
     4321 gtgacggttt ctgaattttc cgagcaagac caggctgtgg ttttccccga gttcagcatc
     4381 ttctcgcagg actgccggga cgagatcgcc cggcagatgt tcgagttgag cgaggatcaa
     4441 cgaatctgct tgcgactgcg gttcttcgac ggcctgtccg tgtcggagac cgcgcaggtg
     4501 atgcggcgca agagcagtgc cgtgcgcgcg ctgcagcacc gcgccgtccg gcgactggcc
     4561 gagctcgtcg atccggtcgc agtggattga tacctgaggt gaacagaagt tgcttcaaga
     4621 acctagccag aaaggtgttc gctgatgacg atggtgtcag ccgagatccc gatggtggtg
     4681 cgtcccttcc tggagaacgc atccgccagc atcgtcattg gcgccgacag gacgacggcg
     4741 gccggaggag accagatccc gaccacggac cctgccaccg gcgctctgct ggcgagcatc
     4801 gctgccggcg gtaaggcgga tgtggatcgt gccgtcgagg ccgcgcacaa ggcattcgcc
     4861 agttggcggc gcctcagccc ggccgcgcgt ggccgcgtac tgctggacgt cgccgacgcg
     4921 atcgacgagt acgcagagga actggccacc ctcgagacgc tggacaacgg gaagccgctc
     4981 accgagtcga cctacctcga cgtcagcctc tccgcgcaga tctggaggta cttcggcggg
     5041 tggaccacaa aactcggcgg gcaaacgctg ccggtctcgc cggcagtggg agacgccctc
     5101 gtctacaccc agcgcgagcc gcttggcgtg atcggcgcga tcgtgccgtg gaacttcccg
     5161 ctgatgatcg cgtcctggaa ggtggcaccc gcgctggccg ccgggaacac cgcggtgctc
     5221 aagccgtccg agttcacctc gctgagcgcc ctgcggctga ccgaggtcgc actcgaagcg
     5281 ggactgcccc ctggtgtgct gaacgtggtg acgggtctgg gaccggaagc cggccaggcc
     5341 ctcatcgacc acccgggtgt cgcgaagatc tcgttcaccg ggtcgacgga gaccgggcgg
     5401 cggatcgtga ccgccagcgc agggagcttg aagaagctca cgctcgagct gggcgggaag
     5461 tccgcgaaca tcgtgttccc ggacgccgac gtcgaggcgg cggtgcaggg tgcactcaac
     5521 gccatcttcc tgaaccaggg acaggtgtgc tgtgcgggct cgaggttgtt cgtgcaccgc
     5581 gacattcacg acgaggtcgt ggccgccgtc gccgcggagg ctcagggaat ccagctgggc
     5641 catggtctgg acgacgacac ccagatgggg ccgttgatct cggcgcggca actggaccgg
     5701 gtggaaggct tcgtcggcgc gggtgttcgt gacggcgcga ccctggtgtg cggcggcgaa
     5761 cgacccggag gcgcgctggc cggtgggcac ttcctcaagc cgacgatctt caccgacgtg
     5821 cgggacgaga tgtccattgc cgccgacgag atcttcggcc cggtgctctc ggtcctgaag
     5881 ttcgacgacg aggacgaggc ggtgcgtcgc gccaactcca gcgtctacgg actcgccgcg
     5941 ggcgtgtgga ccaacgactt gaagcgagcg catcgcgtcg cgcgcgaatt ggaagcgggc
     6001 acggtctggc tgaacatgta caacatgatc gacccggcgg cgcccttcgg cggctacaag
     6061 tcctcgggtt acggccgtga ccttggtgag gagtcgctgc tggggtacac gcagacgaag
     6121 tcggtctggg tcgggatgga ctgaataccc gccgtccgtc cacatttcac agttttccgt
     6181 aagaaactca gcgaggagtt cgaaaatggg tgcgttcaag gacgagtccg aggtctacaa
     6241 gtacatcggt ggtgtcttcg aaaacggtct ggccgacccg gacgtggggc cgaagctgaa
     6301 ggggtccggc gtcgtcctcc agatcaccta caccgatccc gactcggtgc tgacggtcga
     6361 cttccccgcc ggtgaggtac acacgggcgc cagcgacgtg acgccgcacg tcgagctgtt
     6421 catgacggcg gacaccggta accggttctg gctgggcaag gtgaatctgt ccgtcgcgat
     6481 ggccaagggg caggtccggg cgaagggccc ggtctcgaag atcctgaagc tcgtgccggc
     6541 ggcgaagtcg ctcttccccg cctacgagtc gcttctggag cgcgacggtc gtgacgactt
     6601 gctgaaggcg tgagcagcga acgaggaccc gatgacgatg tcgtcggggt gacggaggtc
     6661 aagtaatgcg cagcaccatg cagggcacac cgttgaccgt cgcgtcgatc ctgcggcacg
     6721 gcgtggaggt ccacggcgac cgccgggtga ccaccgcgac ggacgacggg ttccgccgga
     6781 ccacctacga gcaagtgggc aatcggtgcg ggcagctcgc caacgggttg cgtcggctag
     6841 ggatcgccgg tgacgaccgg gtggccacgt tccaatggaa caaccaggaa cacctggagg
     6901 cgtacaccgc ggtccctgcc atgggtgcgg tgctgcacac actgaacatc cgtttgtccg
     6961 ccgagcagat ccggttcatc gccgggcacg ccgaggacaa ggtcgtcatc gtcgacgctt
     7021 cgctcgtacc gttgctggct cgcgtcttac ccgggctgga cacggtcaag gttgtcctgg
     7081 tgaccggcga tggtgatctg tcaccacttg agagctgtgg caaggcggtg ctccgctacg
     7141 aggacgtcct cggagcggag tcaccggaat tcgcgtggac cggcgcggac gaggacgccg
     7201 gcgccgcgat gtgctacacg agcggcacga caggcgaccc gaagggagtg gtgtacagcc
     7261 accgttcgct gtacctgcac tcgatggccg cctgcaccgg caacggcctg gggatcgcgg
     7321 aacaagaccg gatcctgcca atcgtgccga tgttccacgc caacgcatgg ggcctgccct
     7381 acgcggcctt gatggcgggg gccgagctgc tgatgccgga ccggttcatg caggcgtccg
     7441 cgctcgccgg gatggtccac gccgaacggc cgaccctggc cggcgcggtc ccgacaatct
     7501 ggaacgacgt cctccagcac acggagaagg aggacggcct ggacttctcg tcgttgaggc
     7561 tggtggtctg cggtgggtcg gccgtaccgc ggtccctgat ggaagcgttc gagaaccggc
     7621 tcggcgtgac catcctgcag gcgtggggca tgacggaaac ctcgccgctg gcttcggtgg
     7681 cgcgcccggc ggtctccgct ggtcctgacg acgcgtggcg aatgcgggcg acgcagggac
     7741 gtccggtctg cggagtcgag atgcggatcg tcggcgacga cggcactccg cagccgcgga
     7801 acgggcaagt cgtcggagag ctggaggtac gggggccgtg ggtcacgggc tcgtactacc
     7861 aggtcgacga tgacgcacgg ttccacgacg ggtggctgcg cacgggcgac gtcggtcacc
     7921 tcagcgccga gggctacctg acgctgaccg accgcatgaa ggacgtcatc aaatccggtg
     7981 gcgagtggat ctcgtcggtc gagctggagt ccgcgttggc ggggcacccc gacgtgttcg
     8041 aggcggcggt catcgcagca ccggacgaac gctggcagga acgtccgctg gcggcggtcg
     8101 tcctccgcga aggagcgacc gtatcggcag aggaactgcg gtcctggctg tcgggcaaac
     8161 tgccgcggtg gtggctgccc gagcggtggg ccttcaccga ccagattccc cggaccagcg
     8221 tggggaaatt cgacaagaag gtgctgcggg gggactacgc ggacggccgg ttgaaggtgg
     8281 agaccctgga atgaccgtac gcgccacgaa aaaccggcgg tgtaggcgaa tggtgaggag
     8341 gtgagcgcat ggagagcgtc ccaagcacct cgaagatcga attcgacggc gtgacgacgg
     8401 ttctcggcga cgaaccggtg ctgcaccggc tgcggttgtc ggtgccggac gggcaggtca
     8461 cggtgatcct gggacagccc gggtgcggca agacgactct cctgcggcac ctcgtgggcc
     8521 tgctgccgcc gaccggtggc agcgtccgcc tcgacggtca cgacgtctgg tcgctgaaca
     8581 cagcggagct cgccagtgct agaggcggga tcgcggccgt tgtcggcggg gcgcagctgt
     8641 ccgacacttg tctgttctcg tcgatgaacg tctacgagaa cgtcgcgtgc gtcgtgcgtc
     8701 gtaccggcgc gatggacgac gaggtgcgcg cgactaccac gcagctgatg cgggagtttg
     8761 gtctcgacgc ttttgcggag ctgtttcccg aggaagtccc ggcaggggca aggcgcaggg
     8821 tggtccttgt gcaggcgctg atgtccggaa tgcctctgat agtcctcgac gacgtcgaca
     8881 ccgcgttcca cccccgttac acaagcgcct tcgtcagagc gatcaagtcg ctcaacgaga
     8941 aggcgcgggc cacggtgctg atcgcaacgc gcgacctgaa cttcgcgagg gaggtggctc
     9001 acgaggtcgc gatcctctgg aacgggaaaa tcacctcaca cggaccgccg gacgtcctct
     9061 tacgtaacgt gcgaaccgaa gaagagctcg gccggcgata ctttcgacca gacctcaccg
     9121 ggtcggcgca gaaggacgct atggatggcg acttgcggga cgggcggccg gtacgacggt
     9181 tccgcgcgat caagcaggac tacgcggtgt ggtgcgtggt agtgcttctg ctgttggtga
     9241 tcgtcttcgt gctctggtcg agcgcgggca ccgtattcgg cgggcagtga cgatgggcga
     9301 tccatacttg cggactgttc gcacggccga gctgtctgcg ttggcccatg cgatcacgat
     9361 ggtcgaggat catgccgatc tcaaccaccg ctaccaggcg ctgatcgacg actcgcacgt
     9421 cgtgttgagc agtgaccaaa tccggctgac tcaggcacga gggctggcca aacggctggt
     9481 cgtgctggtc aaggcggcgg acaccgagtt gcaagccgaa ctgacgaaaa cccaacgaga
     9541 cgtgatagac gcgggtcttt cccaggctga cgcgctcatc cgaatcatcg attcccacgg
     9601 gtatcggtga aggatagaga ggagcggaaa tgacgaatac cgaatgccgc tgcctgtgtg
     9661 cccctgcggg gcatcacgcg agtctgtgca cggggctggc gcgcccgggc aagttcgtgc
     9721 cgctggccgg cgcgcagccg tctgcccgcg tccccgcgtg tggcccgtgc catcgggcga
     9781 cagtgaccgc cgccgcgggt gtcgtcccgg tccctgtccc gggccggatg gtcgcgcgac
     9841 tgggaacccg agctgacacc gcctgtagct gatgtccgat ttccgattat cgaaggagtc
     9901 atgatggccg agaacactgt ggaacagcct gccgccggca acgatctcgt ggtggccgaa
     9961 gacctgctcg tcgaagaggt ctcgatcgat ggtatgtgcg gtgtctactg acgcggttgc
    10021 cccgttcgat ttggattccg cctgggatct ggacgaacgg gtcgcgatcc ggccggagcg
    10081 gttcggggcg ctgctctacc acttcgggac ccgccgcctg tcgttcctca agagcacggc
    10141 cctcctggct gtggtcaggg ctctggctga gcatccgacg gcgcgtgccg cgtgcgtggg
    10201 tgccggggtc gacagcccgg agctgccgcg ttatcgcgcc gctttggccg ctctggcggc
    10261 gtcgcacatg atccagccga ggagtgtctg atgtcgcttg tggacgagtt tcaatatgga
    10321 ctcgacgcgc ccatctgtct cacgtgggag ctgacctacg cttgcaatct ttcttgcgtc
    10381 cactgccttt cctcgtcggg aaggcgggat ccgcgtgagt tgagcaccgc cgaatgcaag
    10441 gcgctgatag acgagttcga gcggatgcag gtcttctacg tcaacatcgg cggtggcgaa
    10501 cccacggtcc gcgcggactt ctgggagctg gtcgactacg ccaccgagca ccatgtcggg
    10561 gtcaagttct ccaccaacgg ggtgaagatc accgaggcgg tcgcggagcg gctggcagcc
    10621 agtgactacg tcgacgtcca gatctcgttg gacggcgcca ccgccgaagt caacgaccat
    10681 gttcgcggaa cgggctcgta tgccacggcg atccgggcga tggagaacct ggctgccgcg
    10741 gggttcgcga atttcaagat ctcggtcgtg gtcacccgcc agaacgtgag tcagctggac
    10801 gatttcaaga ccatcgcgga ccgctacggt gcccagttga ggatcacgcg gctacgcccg
    10861 tccgggcgcg gcgccgacgt ctgggacgag ctgcacccga ccgctgccca gcagcgtgag
    10921 ctctacgact ggctggtggc ccacggcgag aacgtcctca ccggagattc gttcttccac
    10981 ctcgccggct atggggacgg cggcctgccc gggctgaacc tgtgtggtgc ggggcgagtc
    11041 gtctgcctgg tcgacccggt cggtgacgtg tacgcctgcc cgttcgccat ccacgacacc
    11101 ttcctcgcgg gcaacgtccg cgacggcggg ttcacccgcg tatggcgaga atcggagctg
    11161 ttcgccgaac tccggaaccc acaaggcggg ggtgcctgta gttcgtgctc ggctttcgac
    11221 gcgtgccggg gcggttgcat ggccgcgaag ttcttcaccg gcctgccact ggacgggccg
    11281 gaccccgaat gcgtccgtgg tcacggcgaa ctcgcgctgg ccggagtcgc cgcgggcagt
    11341 gtgccgaagc cgtcgctgga tcactcacat cgacgccgtc cggtaccggt ctccatcggg
    11401 atgcgacgtc cgcccgatcg cgcctgcgac gagaacccgc tcgccgggtt cactccgccg
    11461 ggacggtgag catgcggttg gccgatctgg cgtggccgga catcgccgag cgcgcggcgg
    11521 gcggggcgat cctggctgtg ccggtcggcg cgaccgaaca gcacggcccg catctgccgt
    11581 tgaccacgga caccgacatc gcggtcgcgc tttgcgagcg gctcgccgtc ggacgccagg
    11641 acgtcctggt cgctccgccg gtggcctacg gctcgagcgg cgaacacgcc ggcttcgcgg
    11701 gcacggtgtc gatcgggcag gcggcgaccg aattgctgtt ggtcgagctg ggccgttcgg
    11761 cgtcggagac gttccagcgg cttctgttcg tctcggcaca cgggggcaac agcggtccgg
    11821 tcgcacgcgc cgtcgcccgg ctgcgggcgg agtcgcgaga cgccgaggtc tttcagccgc
    11881 gctggcaagg ggatccgcat gcggggcggc cggaaaccgc gctgcagctg gtcctgaggc
    11941 cggagagcgt ccggatggaa cgcgccgacg cgggcgactg tcgtccgctg gtcgagcttc
    12001 tgccgttgtt gtgcgagagc ggggtcaagg cggtgagcgg gaacggtgtc cttggggatc
    12061 cgacttccgc gacggcacgg gaaggtgaac tgctgctggc agagttgacc gccgcgctcg
    12121 agcgtcaggt ggctgcttgg cacccgatgg tgacacgatg agcccgcggg tcgccgtcgt
    12181 caccggagcg gctcgcggca tcggtgccgg gaccgtgctg cgactggccc ggcacgggta
    12241 cgccgttctc gcggtcgatc gtgcggccaa cgaccctgac ctcccgtaca cgatgggcac
    12301 cgccgccgag ttgtccgtgg tcgtcgaaaa cgcgcgtgag cactccgcgg acatcgcggc
    12361 gtacatcgcc gatgtccgcg atccggtcgc cgtcctctgt gcggtgaccg aagcggaaaa
    12421 ccgctggggc ggaatcgatg tcgccatcgc cgcagccggt gtcgtcgccg gcggcgtacc
    12481 gcagtgggag acgtcgcctg gacaggagcg agctgtgctc gaggtcaacc tgaacggcgt
    12541 cctccacctg gcccgcgcgg ccgtgcccgc gatgctgcgc cgtccgcggc cgcggtccgg
    12601 ccggttcctc gcggtcgctt ccgcggccgc cacccgaggc ctgccgatgc ttgcggctta
    12661 ctgcgccgcg aaagccgggg tcaccggctt gatccgtgcg ctaggcgtag aactgggcga
    12721 taccggcgtg accgcgaacg cggtcagccc cggctcgacc ggcacgccga tcctggccga
    12781 gagcgcaagg ctctacggcc tgcccggcgt ggccgcgttc gccgagcagc agccgatgcg
    12841 gcggctgctc gacccggccg agatcgccgc ggtgctggcg tttctcgccg ggcctgaaag
    12901 ctgtgcgatg actggcgcgg tcgtgccggt ggacggaggg ctggcgctgt gaagtccact
    12961 ccacttccgt tcgggtttcg gatcacgctc gaccgcgagg tcaggcaact ttccggcggg
    13021 ctctggttcg gtggttcccc ggcccgagtc ctacggctca cggaggccgg ccagaaggcg
    13081 tggcaacaac tcgaagacgg cccggtcacg tcagccgcgg cagggacgct cgcgcgacgg
    13141 ctcaccgatg cgggaatggc caccccggtg ccacccgagc cggagggcgc gccggacgtc
    13201 acggtcgtga tccccgctca cgaccgcgtc gacctactgg aacgctgtct gtccgggatg
    13261 gacgatgtcc atccagtgct tgtcgtcgac gacgcgtcgg aagacgccgc agccgtcgcc
    13321 gcgatctgcg cagcatacgg cgccaaacta gtgcgcaggg acgtcaacgg cggccccggc
    13381 gccgcccgga acacggcctt ggagcaggtc accaccgaac ttgtcgcctt ccttgacagc
    13441 gattgtgtac cgaccaaagg ctggatcgac cggcttgcgg cgcatttcgc cgatccactg
    13501 ctggcggcga tcgcgccgcg ggtgcggggg ctggccccgg atagctgggc aggtcgatac
    13561 acacgggcta cgggcagcct cgacctcggc gaccgctcgg cccgcgtcgc gccggggacc
    13621 cgaacctcct atgtgccgac agctgcgctg gtggtccgcc gctccacgct ggtggaagtc
    13681 ggcgcgttcg acccgcggtt gcgggtcggc gaggacgtcg acttgatctg gcggctgcac
    13741 aaggctgacc accggatccg gtacgcggcc gacgtgcacg tcgaccatca cgaaccgacg
    13801 acgtggcacg gagtgctcgg ccgacgagcc cgttacggta catccgccgc gccgttggcg
    13861 ctgcgacacc cggacgcgct ggcgcacctg gccttgcacc cgtggtccat actcaccgtt
    13921 gcggcgctgc tggcccgccg gccccttctc gccgcgacgg cgttcggtgg ttcggtcgcg
    13981 agcatggtcg accagttgca cgccaacgac gttccgcagg ccggcgcggt gcgcgtgatg
    14041 gctactgcgg ctgggcagac ctggctcggc tgtggccgct atgccaccca gttcgctgct
    14101 cctgtgctcg ccgcgctgat ggtgccgggc gggcgacggc gttggggacg tcgtgctgcc
    14161 ctggcctcac tcctgctcgg tccgccgctc gccgggtggg tgaagcgacg tcccgcgctc
    14221 gatcccgttc gctacacggt tgccgccgtt gccgacgaca tcgcctacgg ctccggcgtc
    14281 tgggccggtt gcctgacaca tcgcaccgca gcgccgctac gcccggctgt tgtccggcgc
    14341 cccctgcggt tcgacctgaa gggaaaacaa tgagcaacac ctggttcgag tccatcgcgg
    14401 aagcacagcg gcgcgcgaag aaacgcctcc ccggctccgt ctactccgca ctgatcgcgg
    14461 gctcggaaaa aggcctgacc ctgagcgaca acctcgccgc tttcgacgaa ctacggtacg
    14521 cgccgcgcac tgcgggcctg ccgggcgagc gggagttggg tacccacgta ctcggccgcg
    14581 acgtcgccct gccggtcctg atctcgccaa ccggtgtcca agccgtgcac cccgacggcg
    14641 aggtcgcggt cgcgcgggcc gccgcggcgc gcggaacgtc catgggcttg agttccttcg
    14701 gcagcaagtc cgtcgaagac gtcgtcgccg ccaatccgaa tacctacttc caagtttact
    14761 ggaccggcag ccgcgacgac attctgcgtc gtctcgagcg cgctcgggcg gctggtgccg
    14821 tgggcatcat ccttaccctg gattggtcgt tctcgcacag ccgtgactgg ggaagcccgc
    14881 acatcccgga gcgcctcacc ttccgtgagc tgcttcggtt cgccccagaa ggcctggccc
    14941 acccgcgctg gctgctcgac ttcgccaaga cccggcggct gcccgatctg agcgtgccga
    15001 acatggcgtc cccgggagac accgcaccga cgttcttcgg cgcatacggc cagtggatgc
    15061 agaccccgcc gccctcgtgg gacgacgtga gctggctacg tacacagtgg gacggaccgt
    15121 tcctgctcaa gggcgtaatc cgggtcgacg aggcgcgccg cgcggttgac gccggggtca
    15181 gcgcgatctc ggtctccaac cacggcggca acaacctcga cggaacccca gccacgatcc
    15241 gtgcgttacc cgcgattgcc gacgcggtcg gcagccaggt cgaagtgctg ctcgacggcg
    15301 gcatccgtcg gggcggcgac gtggtgaagg cactcgcact cggcgcccgc gccgtcctga
    15361 tcggccgggc ctatctctgg ggtcttgcgg cgggtgggca agccggcgtg gagaacgtcc
    15421 tggacgtcct gcgcaacggt atcgactcga ccctgctggg tcttggcaaa cgcagcatcc
    15481 acgagctctg tcgcgacgat ctggttgtac ctcagggctt tgcggtcgat ctgggtaccg
    15541 ttgcgaggac ctgaaggcca tctttgtctg agatgttctc gtccgcacca gctgcctagc
    15601 cgggacggac gccgcccacc gcggtcgctt tcgagagcga catccggcag ccgcctccgt
    15661 caccatcggc cggatggatc ggtgatggcg cctgggaccg ttcgcgccca tcaggcaggc
    15721 agcgtagtct ttcgtcctcc ctccgcttgc tgaagttcgt cgcctgccaa cgacgcccgc
    15781 tctgcggata caataccctc gggggtatcg agcaggaggt gggtcgtgga cctggagttg
    15841 gccggtgagg agttgcgggc ggtgttgaac cggctgcgtc gggcccaggg gcagatcgcc
    15901 ggggtgatcc ggatgatcga ggagggtcgt gactgcgagg cggtggtgac gcagttggcg
    15961 gcggtgtcgc gggcgttgga caaggcgggg ttcgcgatca tcgcgaccgg cctgcaacgt
    16021 tgcatcgccg aggggcagtc ggccgacagt gagcagatga agcagcggtt ggagaagttg
    16081 ttcctgtcgc tggcgtgacc cgcgtcagcg gaacgtgcgg atggccgctt cgacgagcat
    16141 gaacgccgcg acggccagca gcacgaaggc gaacacgcgc tgcagtgtgc gggcggatag
    16201 tttcgcggcc aggcgtttgc cgtcccaggc tccgaggatg gccgtggcgg cgaagggcgc
    16261 caccacggcc cagttcaggc tggtcggggt ggtgaccagc cgggtggaca gtgccacggc
    16321 ggagttgagc aggatgacga gcaggctggt ggcgaccgcg gtccgcatgc gcagggagag
    16381 cgtggtcacc agggcgggga cggcgaggaa gccgccgccg acgccgagca ggccggtgac
    16441 cgcgccgagc ccggctccgg ctcccgctgc cttggtggcg ctggtgcgtg tcatggtggc
    16501 cactgagcct tcaccgcggc ttttgttgcg gtcgtgaccg ggatcgtgtg tcggtgcgcg
    16561 ggtgtcgcga agcatcacgg tggcggcgat ggtggcgagc acggcgaacg ccgcggtgag
    16621 agcgggggcg gggatgtggt cggcggcgaa tccggcggcg atcgcggtgg gcaggccggc
    16681 gagcccgaac agcagcccgg tgcgccaggc gacatcggcg gactgccggg ccagggcggt
    16741 cagtgaagtg gcggtgacga tgagcaggct cgcggtggcg gcagcggccg gcggcaggcc
    16801 cagcaggtag accagcgcgg gcacggccag cacgccgcct ccgccgccga gcgcgccgag
    16861 ggcgaggccc acgaccgctc cggcggctag ggcgaacagc aggccgctca cgcgaccgtg
    16921 ccgttcccgc ccagctcgtc gaccacgggc agtcccgcct ggtgccaggc gtgcatgccg
    16981 ccgaccacgt tggagacggt gtggccgcgc tcggccagga tcccggtggc gatggcggag
    17041 cgggccccgg atcggcagat cgcgaacacc ggccgctgcc cgatgtcgac cggtggctca
    17101 gccccgtcac gaagccggga cagcggcagg tggaccgcgc cgggagcgtg gcctgcggtg
    17161 tactcgtcgg tttcgcggac gtcgagaagg accgcctccc cggcgtcgac tgcctggtgt
    17221 acgacggccg ggtcgacggc gccggaggag tccgcgaaca gatcgtgcgg tgacggagtg
    17281 ctcatcgggt gcgccgttcc tcctcgccgg tggcgacggt gaggccgggg atgtcgcctg
    17341 cggcgctgta gtcgtcgtcg atggcgacca cgtcgcggcc tgcggcatcg agcagggagg
    17401 cgccgatggc ggcacgcagt ccgctggcgc agtgcaccca cacccgcccc ggcggcacct
    17461 cgtgcacccg gtcgggcagc gagtggatcg ggatgtgcac cgtgtcctcg atccggctct
    17521 gctcgcgttc ggagtcgcgg cgcacgtcga gcacgaccgg gcgctggccg tcggtgaggg
    17581 cggcggccag ctcggcgaag cccgctcggg ggaaggagga gggtttgtcc ccgtcgagca
    17641 cccagtcctc gggggttccg acaccggcgg cggcgggccg gttgacgccg acccgcacga
    17701 gctcgcgctg ggccgcggcg acctgctcgg gcgactcgcc cagcaaggtc accggcttgt
    17761 tccagggcat cagccacgcc aggtaggtgg ccagcgaacc gtcaccttcg atgttgaccg
    17821 atccggcgac gtgaccgtcg gcgaaggcga tccgtgagcg caggtcgacg acccattccc
    17881 cggccgcgag ccgctcggcg atctccgcgg cgtcggcacg gcgcggtggg gtcagatcga
    17941 ccggagccgg gccggcggcg ttgatcggac ccatgtgcgt gtagtaggcg ggcacgtcgt
    18001 ccagcccggc cagcaacccg gcgacgaagc tgtcgacgtc gctggtcagc gcctcattgt
    18061 cctgcttctg gccgtgtcat gacaaccgtg taagccacgg atggaccaag atcgggtcgt
    18121 cgaacgcgac ccagaagggc tccatctgtg accgagaaca catccgatca ggctgcgggt
    18181 cccgccgccg gcgaggcgct cgctcgcgtg tttccaccgg aaacgcttga tgcgctggtg
    18241 aaagacgcgt atgcgaatgg cggggcgctg ggcgcgcaag aattgctgaa cgagatgacc
    18301 aaggcagtgc tcgagcgagc gttggacgcc gaaatgaccc atcatctcgg atatgagaaa
    18361 ggagacccag ccgggaacgg ttccgggaac tcccggaacg gcaggtcccc gaaaaccgtg
    18421 tccaccacca acgggccggt cgagctcgcg gtgccgcgcg accggaatgg ttcgttcgaa
    18481 ccggcgatcg tgccgaagcg cgcacgtagg ctgggcaata tcgacgaggc catcctgtcg
    18541 ctgtattcgc gcggcatgac cacccgggac atcgaatcgc atttacgtga agtatatggc
    18601 gtgaacgtgt cacgggaatt gatctccaat gtgaccgagg tggtgaccga cgagatcgcg
    18661 ttgtggcaat cccggcccct ggatgagatg tacccgatcc tctatgtcga cggcctgcgg
    18721 ctgcggatca aggacaaggg cgtggtcacc tccaaggtcg cctacctggc catcggcgtg
    18781 gacatggaag gccgtaaaca cgccctcgga ctctggatcg ccgacaccga agcggcgaag
    18841 ttctgggcca aggtcgtcac cgacctgcgc aaccgtggcg tgaaagacat cctgatcgcc
    18901 tgctgcgacg gcctgaccgg actgcccgac gcgatccgcg gcgcgtttcc cgacaccgtg
    18961 gtccaaacct gtgtcgtgca cgtgatccgc aacgccatgc ggttcatttc ctacggcgac
    19021 cggaagaaag tcgccgccgc catgcgggac atctacaccg cgccgacact cgaggcagcc
    19081 gaaatcgcac tcacccagtt cgacaaaaac ttcggcacac aatacccggc cgcgatccaa
    19141 gtctggcggc acgcctggaa cgacttcacc ccattcctcg actatccacc cgaactccgc
    19201 agaatcgtct acaccacaaa cctgatcgag aacatcaact tccaactccg gaaaatcacc
    19261 aagaaccgcg gacacttcga cagcgacacc gccgcgacaa aactgctcta cctcggactc
    19321 cgcaacatca ccagcaaccg aggcggacca tcaggaaccg gaacccgagg ctggaaacaa
    19381 gcactcaaca ccctcgccgc actcttccca gaccgactac cactacacta gaattagaca
    19441 agaaatcatc cgtggcttac acggaaatca tgacagagtc ctgcttctcc gcgccaatgg
    19501 tcgtcgactc gccctgcgcc tgcgaggacg agcagaagct gccgaacccg tgggtgggca
    19561 gcaccggcac cgcgtcgtcg agttcagcgg ccaaccggtg cgccgaggca tgctgggccc
    19621 gcgcgagtga ctcggtcagc cgcggatcga ccaggtcggg ccgccccacg gtgccgatca
    19681 gcagcgaccc gcccgtgaac accgccacgt cgcggccgga gtccaccagt acgtaggacg
    19741 tgtggtgcgg ggtgtgtccc ggcgtggcca ccgcccgcaa cgccaacccc tcagccagct
    19801 cgacgacgtc accgtcggac accgtcgagt gatcgaaggc gacccgcgcc ccggcgggca
    19861 ccatgtaccg ggcgccggtc agccgcgcca ggtccaaccc accgctgacg tagtcgttgt
    19921 gcacatgggt ctccacgacc cacccgatcc gcacaccgct gcccgccgcc gcggccagca
    19981 cccggtcgac gtcacgcggc gggtcgaccg ccaccgccac cgactccgaa cccgcgaggt
    20041 agtgccggtt ccccaggccc tcgaccttga tcgtctcgat gaagtacacg actggagtcc
    20101 tcctctcgtc caaaaatacc ctggggggta tcctcacggt accggatacc acgggaggta
    20161 tgcagatcgc cgagtgcgga cccgcgcaca tttcggggta cccggggcgc gaccgaccga
    20221 cacgacgagc acgaaaggca ggaataccag tgaagtacga gcggagtgtg cgggtgaacg
    20281 ccggatttgc cgacaccgtg gaggcggtgc gccgggcact ggccgagcag ggattcgggg
    20341 tgctcaccga gatcgacgtc accgccaccc tcaaagccaa gctcgaccat gacatggagc
    20401 cctacctcat cctcggcgcc tgcaatccgc cactggcgca ccgggctctg gacgtcgacc
    20461 gcactatcgg cctgctgctg ccctgcaacg tcgtggtccg cgccgacgga gacagcactc
    20521 tggtgcaggc actcgacccg gccacgatgg tcgaattgac cggcctgtcc gatctggccc
    20581 tggtcgccgc cgacgccaca cgccgcctcg acgccgccct gtccggtctc gacgtcatca
    20641 ccgcctgacc gtgtcacctc gcatggacgt gtcactggcg caagcgctgg cctggcgtct
    20701 tgagcggcac tttctcgtca cgggagcgag gtcgatcact gaggtcgttc gccggctcgg
    20761 ggccgttcct gcgtggtcgg gcgaccccgg cctggccatg gggcggcggt tggcccgacc
    20821 gtcgtccgat gcggtcgcgg acgcgttggg cgacggcgac ctgatcagga cctacgcctt
    20881 ccgcggcgcc acgcatctgc tcgccgccga tgacgccggt gtctatttgg cggtgcgctg
    20941 tgcgaaccgc caatgggaac tgccgagttg gcaggcccac tacaacctga gtccgcagga
    21001 ctggctggcc cttcgagagt cggtgcgcga cgttgtcgcg cacggacctg ttcgccactc
    21061 aaaactggcc gagaaggtcg cgagccaccc tcgattccga catctgcaag ccgcactctc
    21121 ccatcccagc cacacactgc tcaagccgct ggcatggcag ggggacctgt gtttcggtcc
    21181 agtccaggac gggcagccca ccttccagtc gccggcatcc agtccccgat ggacaggcct
    21241 tcccgacctt cacgaagccg gaaggagagc agtcctcgcc tatctggccg cttacgggcc
    21301 ggcgacgcgg gacaacttgc actactggct ggtcgcaggt ctcagcgccg gtcgccgacg
    21361 gctggacggt tgggtcggtg atctcatcca ggatcatgtc gccgagatcc aggtcgacgg
    21421 cagccgcatg ctgcacctgc gcgagcacct cgcctcgctg accgcggccc cgaaaccgga
    21481 aggagtgatc ctgctgccag gatacgatca gtgggtgctc ggaccaggca ccgccgacga
    21541 ccacatcgtc cccgcgcgcg ccgcccggcc gtgacccgag gggcgaacgt ggcattgcaa
    21601 gccggacaag tcgcggccac atggaccatc gaccgaggag tgctgaccgt gtcctggttc
    21661 gctgaagcgg gacgcccgcc ccgagcggaa ctcgaggacg agatcgagcg actttccggt
    21721 ctcctgggcc gtgacctcac gatgacgatt gcggtgtcgt gaccccaatc gtcaggtttg
    21781 cccggctccc acccaagcgg gcacggcggc agcgcggatg tcaccgagcc catcaccgaa
    21841 gcggacatgc catcacgcct agcgatacga gaacacccaa gcacggaaat aacgatctac
    21901 ggctggagta ctagtccaca tcgcaaccgg ccaccgagac agcacggccc tgccgtacct
    21961 gtcagcgtga tgatgacgtc tgcgattcat caaccggaac gacgcacgcc gaatggcgga
    22021 cttcggtggc gtgacggacc acttggagcc gacgatggcg agaagcaggg gcggcgaggc
    22081 caagacagcg gcgctgacag gactgcactc tcagacaccc ccgcaagcag ttctcgcccc
    22141 tgccggccga gataaggctt cctcgcgacc cgcccgcctg catcgtccgc ggcacccgcg
    22201 gcacccgcag tacccaggat cggaccgcca cgtccgactt cgcaaccgcc ggatccgaca
    22261 acaggacgga ataatctgac cggaattagt cgggcctact ttgtcagagc acaggtcggc
    22321 ggcgtgtcct ccggcaaagg ttgcttcggc gcggcaccgg ccaatcccgg cacagctcaa
    22381 ctgtcgggct gtcagcgccc cagccacgca ctcatgcgct tgagtagggc cgatccgcgg
    22441 cgcgcgggtt gacactggca acgctgagcg gccggcacgc cgccgagcac ctgctcgacg
    22501 tgttggccac atccggcata cgtagcttta ccacacgaac gacacgtcac ccgacgacac
    22561 atggcaactt tcctctctgc atgtggacca tgcgctaatt ataccccctg gggtatctgt
    22621 aggcacagtg tggcccgacg gagtgttggt tgccaaggga ccgaacggaa agtttggtga
    22681 tccgtcaaga gctcgccatg atcgccaacg cggtcgtcgt atcagcgagg gaacgatgca
    22741 agaatcgacc gatcctccgc gtatgggccg cctactaggg aaggagctca gctggctctc
    22801 tgccgccgga gcaggacaca aatttccgga taggcggtca aggcgactgg atctcgactc
    22861 cgacctactt ctgccgatca agatccgagc acgcccctgt gcgctggccg cttatcggcg
    22921 cgcctgctga ctaccgcgcc atcggcatcc gcgaatccat cgccggggcg aggagtgacc
    22981 gctcgtgtcg acggccgcgt gatcgaggtc ggcagtccgc tccgattgct cgacgacgcc
    23041 caagcccacg cctcgccgcg gtggccgagc tggaagaggc cgggtacacc gttgccgtat
    23101 tcatcgacgg caatccggcc gggatcttgg agctctcaga ccggctgcgg cccggcgccg
    23161 cctcgacgat caggcggctg accgatctca ccggcactga accggcgctg ctcaccggcg
    23221 acaaccgtcg cgccgccacc cgcctcgccg cggaggtctg aatcgccggc gttcacgccg
    23281 gcctgctgcc ccagcacaag gtcgctgcgg tgcgcgagct ggaatcgcgc ggcgccaacg
    23341 tggtcctggt cggcgacggc gtcaacgacg cacccgcacg ccaccgccga accgctgacg
    23401 agcggcacac gcggaccggt acggtcggcg tccttccgaa cgccaccgcg cccagcagat
    23461 tgccgagcgc gttcacccca tagacgacgc tggtgagttg ggccgatgcc tcgttaggcg
    23521 gttgaagggt gcgcgcaccg gcaggccacc ctggtcggca ggtttacaga ccccggagtc
    23581 ggccggagcg gcgcccagca ggtgtaaagc tgggcgccgc cgagcaggga agttcgccct
    23641 acttggacgc cgcggtcgga gtgcgtgagg atcgtcgata caacagcact tgctgtatga
    23701 ccacgagcag gactggcacg gccgcgatcc tggccagcca cgggtatccc cacgcgtcga
    23761 gcacggcgcc ggcggggaag gcggcgagtg cggcggccag ttgcatgagg aggtcggata
    23821 cgccttgtgc gtgggggcgg tcggattctt gcaccgatcc ggtcaggagc gctgatccgg
    23881 cgacgaagcc ggccgaccat ccgagtccga gtaccaccag tccgatgatc attacggtga
    23941 cggagttatc gtgggtcagt tgaaggattc cgcaggcggt cagcaacagg ccgagtccca
    24001 ggccgagaac tttccgcgcg ccgaaccggt cgaccagcca cccgaacagt ggagacagga
    24061 agtacatgcc ggcgaggtgg gcgctgatcg cggcgccgac gacgcggagc gattcaccgc
    24121 cgtggtgcag gtgcagagag gccatgttca tgccggagac catgacggcg tggacgacgg
    24181 cgaccgcgat gacggctcgg cgtgcttcgg gcgtgcgggc gagcattcgc agggtaggcc
    24241 gcagccggct gcggttggct tgagcgagct tggtgtcgtc ggccgttcgg gcccgggcga
    24301 ccaacagcgg gtcgggccgc agccagatgt gggcggcgcc ggccgcgacg agcaggccga
    24361 ttccgatcac gagaaagggg ccggtgaaag ggggcagtcc ggctgcgcgg gcgacatcat
    24421 cggaggggcc ggcgagcagc gggccggcga caccgccgaa ggtggaggcc cacacgacgg
    24481 ttccgatggc gcggccgcgt tcgcccggtt cggcgaggtc ggtggcggcg aagcgggcct
    24541 ggagcccggc ggcggcggcg gccccggcca gcgtggtgcc gagcaggacc agtggaaaga
    24601 actcgacgat gccgccggcg accacgagcg cggaaccggt ggccgcggtg aggtagccgg
    24661 tggtgacgcc gatgcggcgg ccaccgcgga cggtcacgct ggccagtgga accgcggcga
    24721 ggacgccacc ggcgatcgtc gcggcctgag cgataccggc gagggtcgag gagtgggtga
    24781 agtcttggac cagtagcgcg gcgacaggtg atgccatcgc catcacgacg gcgaagatta
    24841 tctgcgtgcc gaggagaatc gtgatcgtgc gtcgctggac cgcgcgcacg tcgatatcgg
    24901 tgaggttgtg tgacacgtgc ttgctccctg gatgggcgtc gcacgggaag gcagagccgc
    24961 cggatggcgg agaattcccg gaacgcgact ggatgacagg accggcgaac cggtcctgtc
    25021 atccgcaggt gtcacagcct tgggcgggcg atgtcccgtg cccaggcatt cggcgggcgc
    25081 ggcgccggcg cgtcagaccg ccattgggtg gtgcgccgac cgcgattccc gaagaacgaa
    25141 cgcgtcgaag accgcggccc gtggagcgat tccctcgggt ttcggtggga gacgaagtgc
    25201 ggatcatcgg tcctcgaaca aggatgtgct gaggtagcgt tcgccggtgt cggggaggat
    25261 taccacgatg acggcgttgt ggtgctcgac ctgccgtgcc atgtggcacg cggcgtgcaa
    25321 ggcggcgccg gccgagactc cggcgaggat tccttcggtc cgcgccaggc gacgcgcggc
    25381 cgcgcgggca tcgtcgagcg acacggggag aacgtggtcg tagatctcgg tgtccagaac
    25441 ctccggcacg aatccggcac cgattccctg gatcccgtgt ggcccgggtg ccccaccgga
    25501 caggacggct gagtcggtcg gctcgaccgc gaccacggtc aaatcgggat tctt
//
