LOCUS       NZ_LT629789            22026 bp    DNA     circular CON 13-MAY-2024
DEFINITION  Amycolatopsis keratiniphila strain FH 1893 chromosome I.
ACCESSION   NZ_LT629789
VERSION     NZ_LT629789.1
KEYWORDS    RefSeq.
SOURCE      Amycolatopsis keratiniphila
  ORGANISM  Amycolatopsis keratiniphila
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Amycolatopsis; Amycolatopsis japonica group.
REFERENCE   1
  AUTHORS   Varghese,N. and Submissions,S.
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2016) DOE - JOINT GENOME INSTITUTE, LBNL, 2800
            Mitchell Drive, Walnut Creek, CA 94598, 94598, USA
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_900105855.1-RS_2024_05_13
            Annotation Date                   :: 05/13/2024 02:01:53
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,886
            CDSs (total)                      :: 8,813
            Genes (coding)                    :: 8,742
            CDSs (with protein)               :: 8,742
            Genes (RNA)                       :: 73
            rRNAs                             :: 4, 4, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 4, 4 (5S, 16S, 23S)
            tRNAs                             :: 58
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 71
            CDSs (without protein)            :: 71
            Pseudo Genes (ambiguous residues) :: 0 of 71
            Pseudo Genes (frameshifted)       :: 26 of 71
            Pseudo Genes (incomplete)         :: 51 of 71
            Pseudo Genes (internal stop)      :: 1 of 71
            Pseudo Genes (multiple problems)  :: 6 of 71
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 18:07:53
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 8229125
            Orig. end                         :: 8251151
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            LT629789.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22026
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="redox-cofactor"
                     /region_number="30"
                     /rules="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /tool="antismash"
     cand_cluster    1..22026
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(cds(PF04055 and (TIGR04085 or SPASM))
                     and (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /kind="single"
                     /product="redox-cofactor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22026
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12026](-)"
                     /cutoff="20000"
                     /detection_rule="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /neighbourhood="10000"
                     /product="redox-cofactor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12026)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /neighbourhood="10000"
                     /product="redox-cofactor"
                     /protocluster_number="1"
     misc_feature    complement(51..65)
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 18.7"
                     /tool="antismash"
     gene            1066..1542
                     /locus_tag="BLU53_RS37790"
                     /old_locus_tag="SAMN04489733_7737"
     CDS             1066..1542
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007033810.1"
                     /locus_tag="BLU53_RS37790"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04489733_7737"
                     /product="DUF4262 domain-containing protein"
                     /protein_id="WP_072030139.1"
                     /transl_table=11
                     /translation="MCWHCDNPGKTREDYLVEEVRPLIRKYGWMVQTVERGIVQPGFAY
                     TVGLTDAGLPELVVTGLRERRSGQLLNYFAQQVVRSGPPEPGEVLPAEVGWPSLEVVPL
                     SSPPAHLLTAVLLYGENFRALQLVYEDEHGNWPWDREFRGGTGGQPVLGARGRG"
     gene            complement(1547..2239)
                     /locus_tag="BLU53_RS37795"
                     /old_locus_tag="SAMN04489733_7738"
     CDS             complement(1547..2239)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1071: GntR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007033809.1"
                     /locus_tag="BLU53_RS37795"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04489733_7738"
                     /product="GntR family transcriptional regulator"
                     /protein_id="WP_063271598.1"
                     /transl_table=11
                     /translation="MSLPDIEPVSRESTAGIIARQLRDAIMTGALPPGTQLGETDLASR
                     FQVSRGPLREAMQHLVSEGLLRSERHRGLFVIDLEPGDVYDIYSARSAIERAAMLRALR
                     GDRERVATELEEAVHAMAAAADEDDPTALSWADLRFHEALIAASGSKRLVRMARTLLIE
                     TRMCLTALQGTYQRVEERVTEHTSIIEALRAGDEETALSLLEAHMEDAVQRLAPGTSLR
                     EGEAPAVP"
     gene            complement(2243..3013)
                     /locus_tag="BLU53_RS37800"
                     /old_locus_tag="SAMN04489733_7739"
     CDS             complement(2243..3013)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007033808.1"
                     /locus_tag="BLU53_RS37800"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04489733_7739"
                     /product="maleate cis-trans isomerase"
                     /protein_id="WP_063271599.1"
                     /transl_table=11
                     /translation="MPITPFAPPEPPSETTTIGFIYPDHAAEDDYPLAEQLLGGDMAGI
                     KLPVEHIYGTDLHAVPELLDLGSESRLADGAALLAKHEPDAVVWACTSGSFVYGWEGAR
                     DQADRLAAVAGVPASSTSFAFVNAARALGVRRVAVAASYPDDVARLFVEFLGAGGIEVV
                     SMGSADIDTAAEVGDLSPEAVVELAVSRDHPAADALLVPDTAMRTLGEINTLETRIRKP
                     VLTANQVTVWEGLRLTGKSPLVRTLGALFGQRSS"
     misc_feature    3037..3052
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 18.16"
                     /tool="antismash"
     gene            complement(3060..3800)
                     /locus_tag="BLU53_RS37805"
                     /old_locus_tag="SAMN04489733_7740"
     CDS             complement(3060..3800)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020631263.1"
                     /locus_tag="BLU53_RS37805"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04489733_7740"
                     /product="maleate isomerase"
                     /protein_id="WP_016336992.1"
                     /transl_table=11
                     /translation="MDFDLLEFEGPLAQRGIGVIAPFDLALERELWRWVPMEVSLHLAR
                     TPYEPVPVSMEMAQLVSDSRHLAAATRDVLHVEPEVVAYLCTSGSFVNGVDYERSLTKA
                     ICDAGATDAVTTSGALAEVLHQLDLHRVSVLTPYDGDLTGKLHDFLAELGVRTVSSDHL
                     GLGGGIWKVSYRTIAERILAADHADAEAIFVSCTNLPTYDLIEPLESALGKPVLTANQL
                     TMWACLRRMNLPIVGPGKWLREVD"
     misc_feature    complement(3786..3788)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            3901..4890
                     /locus_tag="BLU53_RS37810"
                     /old_locus_tag="SAMN04489733_7741"
     CDS             3901..4890
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) 2-Hacid_dh_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1072: dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016336991.1"
                     /locus_tag="BLU53_RS37810"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04489733_7741"
                     /product="D-2-hydroxyacid dehydrogenase"
                     /protein_id="WP_083715476.1"
                     /sec_met_domain="2-Hacid_dh_C (E-value: 7.3e-49, bitscore:
                     164.5, seeds: 135, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIASETPVLAVLCGDTRPPDMRAIEAEAVVRYTDAAGLADALSGA
                     DAFFVYDFLSTAVPGAWHAADRLRWLHIASAGVDPVLFPGLQESDVVLTNSRGVFDGAI
                     AEYVLGVVLTFAKDFARSWDLQKQRQWKHRESERIAGRRALVVGTGPIGRSIARMLRAA
                     GLSVAGVGRRPRADDPDFGDVYASSELSRHLPGADYVVAVAPLTEQTKGMFDAEAFAAM
                     KPGSRFVNVGRGELVVTSDLIGALRNGPLGGAALDVFDTEPLPAESPLWTMENVLISPH
                     MSGDFVGWRNTLVEVFADNFRRWRAGEPLRNVVDKRLGYVPSETLRQG"
     misc_feature    4024..4026
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            4899..6275
                     /locus_tag="BLU53_RS37815"
                     /old_locus_tag="SAMN04489733_7742"
     CDS             4899..6275
                     /EC_number="3.5.1.4"
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1105: amidase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005150551.1"
                     /locus_tag="BLU53_RS37815"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04489733_7742"
                     /product="amidase"
                     /protein_id="WP_063271601.1"
                     /transl_table=11
                     /translation="MNDTKLTASELVAAYATGELSPVEATQNALRAIEERDGETNAFCL
                     VDADGALEQAKASEIRWRDGNPIGWLDGVPASIKDMFLTQGWPTLRGSRCIDPDQPWDV
                     DSPVTARLRENGLVLLGKTTTPELAWKGVTDNTLTGITRNPVDPSTTAGGSSGGSAAAV
                     AAGMGELSVGTDGGGSIRIPASFCGIVGLKPTHGRIPLFPASPFGPLSHAGPMARSVDD
                     TALLLDVLAMPDYRDPAALAPPVSTYREAVRRDVRGLIAAYSPTLGYVDVDPEVAEIVK
                     SAVQSLGDAGLHIEEADPGFADPKPAFDILWSTGAAKWLDTFPAGSETKVDPGLRKVWE
                     LGKTFSASDYLGANAERAALGILMGEFHTRYDVLITPTLPIPAFEAGHEVPPGSGLSGW
                     PDWTPFTYPFNMTQQPAISVPAGRTSSGLPVGLQIVGPRHSDDLVLAVAKLLEEVRPWP
                     "
     gene            complement(6327..7547)
                     /locus_tag="BLU53_RS37820"
                     /old_locus_tag="SAMN04489733_7743"
     CDS             complement(6327..7547)
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1020: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016336989.1"
                     /locus_tag="BLU53_RS37820"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04489733_7743"
                     /product="MFS transporter"
                     /protein_id="WP_072030140.1"
                     /transl_table=11
                     /translation="MTSLREPLRHHNFRWLIAGRTFGEFGNAVAPLALAFAVIDLTGSA
                     VDIGIVVGARSVASVVLLLFGGVLADRLPRSVILQGTEVAATLTQAVIAASVLCGFASI
                     PLLVALSVVNGAVAAISAPASASLTPLTVPATQLAQANALARLLSNSGRIAGAGLGGIL
                     VTAVGPGWALAGNALLFLGSALSYRCIRLNRRERVPGSRPLAELAEGWREFRSRTWVWV
                     VVVQFMVVNAVIAGGIAVLGPVVADSTFGRSGWGFALAAQTIGSLVGGILVARWQPRRA
                     LFVGVAVILFEAPPLILLGQAPLLPLLLAAMFVSGLAIEQFVVAWDVSLQENVPEDKLA
                     RVYSYDMLGSFIALPLGQMAAGPAAQHFGVSTTLLACAALVVAATCLALCSGQVRGLVR
                     KTHAAQP"
     gene            complement(7544..8062)
                     /locus_tag="BLU53_RS37825"
                     /old_locus_tag="SAMN04489733_7744"
     CDS             complement(7544..8062)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007033803.1"
                     /locus_tag="BLU53_RS37825"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04489733_7744"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_072030141.1"
                     /transl_table=11
                     /translation="MSESPGLDGLRVLAHPLRLRILSLLTGVAMSAAEAARELGETQAN
                     VSYHVRRLHEAGLLDVAEEVRIRGGLAKRYRHDPESGMRFTSKNPDEEQLLIAAMVEEL
                     KRRSEFRLPDERGSINDAEMWVDRETWEKALEHARELSALLHSAAKPPRTRGTIPVSAT
                     VAMFEMRRP"
     misc_feature    8144..8159
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 21.59"
                     /tool="antismash"
     gene            8170..9144
                     /locus_tag="BLU53_RS37830"
                     /old_locus_tag="SAMN04489733_7745"
     CDS             8170..9144
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1039: aldo/keto reductase family oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009082804.1"
                     /locus_tag="BLU53_RS37830"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04489733_7745"
                     /product="aldo/keto reductase"
                     /protein_id="WP_072030142.1"
                     /transl_table=11
                     /translation="MRTTTLGRSGLEVSRIAFGTWQLGGDWGSFDEDTAIAAIHHAREL
                     GVNLFDTAQAYGFGKSEAMLGKALREELKRDRDNLVIATKGGIKPRSERPRDSRREWLT
                     QGVEDSLRFLDVDHIDLYQIHWPDSDAPAEETAGILQEFVDAGKIRHVGVSNYDAAGLA
                     AFDKTRPVETLQPPYHLFRRDIETDPLPYARENDIGVLVYSPLGSGLLTGAFTPETTFE
                     KTDWRSRSSAFTGDTFLRNLAVVDRLKEFAADKGISVSQLAIAWTLAQPGVHVAIVGAR
                     KAANIEASLAAADIDLSADELVEIDRLTADAVPVSGASPEGVA"
     gene            complement(9141..10004)
                     /gene="pqqB"
                     /locus_tag="BLU53_RS37835"
                     /old_locus_tag="SAMN04489733_7746"
     CDS             complement(9141..10004)
                     /codon_start=1
                     /gene="pqqB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020631257.1"
                     /locus_tag="BLU53_RS37835"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04489733_7746"
                     /product="pyrroloquinoline quinone biosynthesis protein
                     PqqB"
                     /protein_id="WP_072030143.1"
                     /transl_table=11
                     /translation="MRVILLGTAAGGGFPQWNCACALCVSDAPPRTQDCVAVSADGEGW
                     YLLNVSPDIRAQILTTPPLRAGPGPREIPLRGVLLTDAELDHSLGLLLLREAGGLPVWA
                     PEAVLDALSEQFPARSIIDGYGGWDWLPSSDVSIDGLRVSMLPVSDKRPKYARSSTEDG
                     PWVVAYRIEDVRTGGVFVYAPCLKSWPDGFDDFTRDAGLVLLDGTFYAPDEMSGATAAE
                     VGDGAQLAMGHLPITGSLAKLRPGPRWVYTHLNNTNPVIDPASPEHAAVLAGGASLPLD
                     GTEFKL"
     gene            complement(10001..11080)
                     /gene="pqqE"
                     /locus_tag="BLU53_RS37840"
                     /old_locus_tag="SAMN04489733_7747"
     CDS             complement(10001..11080)
                     /GO_process="GO:0018149 - peptide cross-linking [Evidence
                     IEA]"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: PF04055"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: TIGR04085"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: SPASM"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005150538.1"
                     /locus_tag="BLU53_RS37840"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04489733_7747"
                     /product="pyrroloquinoline quinone biosynthesis protein
                     PqqE"
                     /protein_id="WP_172843566.1"
                     /sec_met_domain="PF04055 (E-value: 2.4e-21, bitscore: 75.8,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 1e-05, bitscore: 24.8,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="SPASM (E-value: 5.3e-09, bitscore: 35.4,
                     seeds: 166, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 1.2e-10, bitscore:
                     40.6, seeds: 281, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDLNTAPPLGMLAELTHRCPLHCPYCSNPVELIARDGELSTEEWI
                     SVLSQARELGVLQVHMSGGEPLARPDLPILVEHATKLGCYVNLVTSGLGLTESRLDDLV
                     ERGIAHIQLSVQGATADRADRLAGARAHDRKLVAAGLIKKAGLPLSVNVVLHRQNHDQL
                     AGIIDLAEKMGADRLELANTQYYGWALRNRDALMPTRRQLEEAEPIVRAATERLRGRME
                     IIYVVADYYEQYPKPCMYGWGARQLTVAPDGDVLPCPASTAIETLEFDNVRDKPLAWIW
                     YESASFNAYRGEDWMPDTCGTCERRAIDFGGCRCQAFQLTGDAAATDPVCSRSPHRGVV
                     DLILATPAKTDELVMRSPR"
     gene            complement(11071..11343)
                     /gene="pqqD"
                     /locus_tag="BLU53_RS37845"
                     /old_locus_tag="SAMN04489733_7748"
     CDS             complement(11071..11343)
                     /GO_function="GO:0048038 - quinone binding [Evidence IEA]"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqD"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: PqqD_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016336984.1"
                     /locus_tag="BLU53_RS37845"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04489733_7748"
                     /product="pyrroloquinoline quinone biosynthesis peptide
                     chaperone PqqD"
                     /protein_id="WP_063271606.1"
                     /sec_met_domain="PqqD_RRE (E-value: 8.2e-24, bitscore:
                     82.2, seeds: 9, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 3.9e-10, bitscore: 38.9,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTLDLGSVPRLRRGVRLSYDQTRETHVLLFPEGVLVPNPTAAAV
                     LSLCDGVEDVAAIASALRERYTGVREEEILDVLSRLGDRRIVEWT"
     aSDomain        complement(11080..11340)
                     /aSDomain="PqqD_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing protein in a pyrroloquinoline
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_BLU53_RS37845_PqqD_RRE.1"
                     /evalue="2.60E-26"
                     /identifier="RREFam006.1"
                     /label="BLU53_RS37845"
                     /locus_tag="BLU53_RS37845"
                     /protein_end="88"
                     /protein_start="1"
                     /score="82.2"
                     /tool="antismash"
                     /translation="TTLDLGSVPRLRRGVRLSYDQTRETHVLLFPEGVLVPNPTAAAVL
                     SLCDGVEDVAAIASALRERYTGVREEEILDVLSRLGDRRIVE"
     gene            complement(11346..12026)
                     /gene="pqqC"
                     /locus_tag="BLU53_RS37850"
                     /old_locus_tag="SAMN04489733_7749"
     CDS             complement(11346..12026)
                     /EC_number="1.3.3.11"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: TIGR02111"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020631254.1"
                     /locus_tag="BLU53_RS37850"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04489733_7749"
                     /product="pyrroloquinoline-quinone synthase PqqC"
                     /protein_id="WP_063271616.1"
                     /sec_met_domain="TIGR02111 (E-value: 1.2e-84, bitscore:
                     282.4, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSSSEFIAALRGLSHRYWGTHPFHVRMHNGDLSEYELKIWAANRW
                     YYQCVLPQKDAAIISNCPLPEIRREWLDRIVYHDGTKAGDGGIERWLRLCTAVGLDREE
                     VLDQRHVAPGVRFAVDAYVTFARTKPWLEAVASGLTEMFAGHLMQRRVADMLANYSWIA
                     PEDLAYFTNRIDKVSGEGKGTLDIVVRHAVTREQQEKAIAALSFKTDVLWSMLDAIERA
                     AAKE"
     gene            complement(12112..12207)
                     /gene="pqqA"
                     /locus_tag="BLU53_RS37855"
                     /old_locus_tag="SAMN04489733_7750"
     CDS             complement(12112..12207)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007033797.1"
                     /locus_tag="BLU53_RS37855"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04489733_7750"
                     /product="pyrroloquinoline quinone precursor peptide PqqA"
                     /protein_id="WP_043848360.1"
                     /transl_table=11
                     /translation="MTETIEVWTTPDFVEYETPMEVTAYAARMED"
     misc_feature    complement(12283..12299)
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 16.86"
                     /tool="antismash"
     misc_feature    complement(12286..12299)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 14.78"
                     /tool="antismash"
     gene            12462..13448
                     /locus_tag="BLU53_RS37860"
                     /old_locus_tag="SAMN04489733_7751"
     CDS             12462..13448
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020631253.1"
                     /locus_tag="BLU53_RS37860"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04489733_7751"
                     /product="PQQ-dependent sugar dehydrogenase"
                     /protein_id="WP_063271607.1"
                     /transl_table=11
                     /translation="MSLRRILAATFAAATAVSIAAVPATAAEAPSVQAIRQLASGLNQA
                     WSIDFLPDGTGLFTQKDAKTISKIDKAGKVTTVQTIPGVSVTAEAGLLGIAVSPKYATD
                     ETVFIYYTTSSDNRIAKLKLGQPPTPIVTGIPRGSQYHHGGRIRFGPDGYLYAGTGDGQ
                     NGANAQNKNSLGGKVLRVTTDGAAAPGNPFNSRVYSYGHRNVQGLTWANGQLYISDIGA
                     NRLDELNRIEPGKNYGWPTCEGPCNTAGMTNPVKSWPTSSATPSGLAAYKGSLYMASLK
                     GGTYKLDLNGNGGKLWTNLGRTRDATAGPDGQLYTITPGGLYVSDGS"
     misc_feature    12468..12470
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(13500..14876)
                     /locus_tag="BLU53_RS37865"
                     /old_locus_tag="SAMN04489733_7752"
     CDS             complement(13500..14876)
                     /EC_number="2.3.1.-"
                     /GO_function="GO:0008374 - O-acyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016336981.1"
                     /locus_tag="BLU53_RS37865"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04489733_7752"
                     /product="wax ester/triacylglycerol synthase family
                     O-acyltransferase"
                     /protein_id="WP_072031293.1"
                     /transl_table=11
                     /translation="MPFMPVTDSMFLLVETREHPMHVGGLQLFKKPEDAGPEYLRDIRR
                     KLLDSDNMRSVFRRRPARPVNTAGHLAWSTDTDLELDYHFRHSALPQPGRIRELLELTG
                     RWHSTLLDRHRPLWEIHLVEGLQDGRFAIYSKIHHALMDGVSALRHLQGTLSDDPADLD
                     CPPPWGRRAKPDGGRNGKASPSVLSTFGKTVNQLAGIAPAAMKVAREAFQEHTLTLPAQ
                     APKTMLNVPIGGARRFAAQSWSLDRVRKVATAAGVSRNDVVLAMCSGALRDYLIEQNAL
                     PDAPLTAMVPVSLRRKDSGDAAGNNIGALLCNLATHLTDPAARLATINASMRNGKKLFS
                     ELTPLQTLLLSGINVAQLGISPIPGFVNNTKPPFNLVISNVPGPRKQMYWNGAALDGIY
                     PASVLLDGQALNITLTSNGDNLDFGVTGCRRSVPHLQRILTHLDTALVELEDAVSLPRV
                     "
     gene            14973..15986
                     /locus_tag="BLU53_RS37870"
                     /old_locus_tag="SAMN04489733_7753"
     CDS             14973..15986
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GST_C"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007033794.1"
                     /locus_tag="BLU53_RS37870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04489733_7753"
                     /product="glutathione S-transferase C-terminal
                     domain-containing protein"
                     /protein_id="WP_072030144.1"
                     /sec_met_domain="GST_C (E-value: 1.5e-07, bitscore: 30.5,
                     seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTIPTDPQTGEFRRSANHFDARVTADGRDGWPVEAGRYRLVVSRA
                     CPWASRGLVVRRLLGLESALSVAVADPIQDEKSWRFTLDPGDRDPVLGIKYLAEAYHAA
                     DPHYMGGISVPAIVDIPSKRLVSNDYPQITLDLSTEWTSLHRPGAPDLYPERLRGEIDD
                     VNAGVYADVNAAVYQAGFATKQAAYEDAYTRLFTMLDVLSERLEKQRYLVGDTITEADI
                     RLFTTLVRFDAVYHGHFKCNRNKLAEMPVLWAYARDLFQTPGFGDTVDFDHIKRHYYAV
                     HEQVNPTRIVPLGPDLSGWTTPHHREQLGGRPFGDGTPPGPPPEDERIGDTDGVTA"
     gene            15970..17127
                     /locus_tag="BLU53_RS37875"
                     /old_locus_tag="SAMN04489733_7754"
     CDS             15970..17127
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1103: FAD dependent oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005150529.1"
                     /locus_tag="BLU53_RS37875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04489733_7754"
                     /product="FAD-binding oxidoreductase"
                     /protein_id="WP_072030145.1"
                     /sec_met_domain="DAO (E-value: 1.5e-67, bitscore: 227.6,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MESLPERTDVVVIGGGIIGVACAYRLAAAGVSVLLLERDTLGAGS
                     TAKAAGGIRSSFTTRVNIEIGLRGLAEYASFAETYGTEIDFRRDGYLYLITDPADLPEF
                     ERCAELQNSYGVRSRLVEPAEARRFSPLIDTEGVVAALWSPDDAKATPDSAVQGYARAA
                     RGHGAVLKTGVEVVGIERDGDEITGVRTSAGSVRTEAVVCAAGAWSGRIGELAGVELPV
                     RPYRRQVVFTGPVADLPGRVPLTIEMPSAFYFHREGLGLAMSFCDGDGDPGFDTRYQPG
                     EWLPKLAEIAARRVPAVLGAGIRGGWAGLYEVTPDRNQIVGESVHLSRFFYATGFSGHG
                     FQMGPAVGELVRDLYLGRVPAIDITGLDVRRFAGDRAVTREHNIV"
     gene            17120..17743
                     /locus_tag="BLU53_RS37880"
                     /old_locus_tag="SAMN04489733_7755"
     CDS             17120..17743
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007033792.1"
                     /locus_tag="BLU53_RS37880"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04489733_7755"
                     /product="pyridoxamine 5'-phosphate oxidase family protein"
                     /protein_id="WP_072030146.1"
                     /transl_table=11
                     /translation="MSEFVEVTTEAELREILPPPLERTANKARPKLHELDRQWLAESPF
                     VLIATSAADGTCDVSPKGDPAGFTLVLDDTRIAIPERPGNRRADGFHNVLSNPHVGLIY
                     LIPGRGDTLRINGRARLVREAPFFDDMIVKGNRPKLALVVDIDEIFHHCQKAFMRSKLW
                     SPESWTPEALPSRAAISKTFERPEDSLADLEAYYAPAAYSAGLY"
     gene            17793..19424
                     /locus_tag="BLU53_RS37885"
                     /old_locus_tag="SAMN04489733_7756"
     CDS             17793..19424
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TPP_enzyme_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055: pyruvate oxidase/decarboxylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016336977.1"
                     /locus_tag="BLU53_RS37885"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04489733_7756"
                     /product="thiamine pyrophosphate-binding protein"
                     /protein_id="WP_072030147.1"
                     /sec_met_domain="TPP_enzyme_N (E-value: 1.2e-55, bitscore:
                     186.7, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 5.4e-27, bitscore:
                     93.5, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPAPTGAQHLADALTALGTEVVFGLPGVHNLPLWEALADTDIRLV
                     GVRHEQTAGYAADGYARATGKLGVALVTTGPGAANTLAAVGEAMASAAPVLIIATDIPS
                     TLRRPGVVRGVLHETSDQQAMFAPVTKAGFTVTSADQVAATLHRAARLALQPQSGPVYL
                     GIPTDFLSERTPARRPPRSHARPAEIPDLSEAEAMLAAADRPLIWAGGGALRAEAGEAI
                     GKLAERLAAPVLTTFGARGLLSVDHPCLAPNPVHAPEVGALWDEADVVLAIGTDFDGLM
                     TQNWLMPKPKKLIAINVDPDDAAKNYQPDITLVGDARVLVEALKVEERSGIAALVGRLA
                     KVSARVRRRIKEEEPQAADLLSTLDEVLPPDAVVVADMCVAGYWIGGFHRVRAPRKLAY
                     PMGWGTLGYGFPAALGAAAAGGGRAICVTGDGGFLFDCGDLHTLAQEQLPVTTIVVDDG
                     GYGMLRYDQDRAGLPRRGVDWDSPDFVGLARSFGVHADRVSGFGRAFRRLLGEFVESDE
                     PNVLVVRAKMAPPLNTSPRWYRKESP"
     misc_feature    17889..17891
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            19421..21475
                     /locus_tag="BLU53_RS37890"
                     /old_locus_tag="SAMN04489733_7757"
     CDS             19421..21475
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005150523.1"
                     /locus_tag="BLU53_RS37890"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04489733_7757"
                     /product="hydantoinase/oxoprolinase family protein"
                     /protein_id="WP_072030148.1"
                     /transl_table=11
                     /translation="MTGLRVGVDIGGTFTDLCVLDETGVVAVGKVLTTHDEPARAVEEG
                     LKRTLADAGLVAGDVEQFVHGTTLVTNALIERKGARTALLATAGFRDVLEMRREHRYQL
                     YDLLIELPAPLVPRHLRFDVPERILADGSVHTGLDEEYVARLGRELDARGIDAVAICFL
                     HAFTNPAHERRAAEVLEEVAPRLRVALSSEVVPEIREFERTSTTVANVYVQDLTERYLR
                     DLERRLHESGVRPSPHIMLSNGGIATVDTAARHPIRILESGPAGGALAASAIGAAAGVD
                     DLLAFDMGGTTAKLCMISGGAPLVTHEFEVDRKYRLLPGSGLPVKVPVTDMIEIGVGGG
                     SIARIDALGLLTVGPDSAGSEPGPVCYGRGGTEPTVTDADLVLGYLDPGYFLGGGMTLD
                     AEGAREAIRSKIAGPLGVSVEEAAWGIHTSVNEDMANAARVHAVERGKDPAKLPMFTFG
                     GAGPVHGVGVARALGAPEVVAPPAAGVLSAAGFLTAPLAFDFVRSARAAVLDLSWEQVD
                     ALFAEMEAEGTELLRKSGVDDVTHRRIAEMRYSGQGYEIRVPVERGNWPESLIGAFTET
                     YRTLYRRTGPDVGIEVLNWRVVSSGPTPEVTLKLAGAEAQGDARKGSRPAYFPASGGFV
                     DTAVFDRYGLKPGDRVDGPAIVEERESTVVVPPGARCVVGEDASLVVAV"
     misc_feature    21621..21635
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.8"
                     /tool="antismash"
ORIGIN
        1 tctggccaac gagttcgtct tacaggaatc cgtgttcacg cgggtcgggg tggagcggat
       61 catccgctat gccttcgagt tggcgaagac gcggacgggg cgggtctgct cggcgaccaa
      121 atccaacggg ctcattcact cgatgccgtt ctgggacgag atcttcgccg agatcacttc
      181 ggagtatccg gacgtgcacg ccgaacaatg ccatgtcgac gcgctcgccg cgcggatggt
      241 gcaggcgccg gaccggctcg acgtcgtggt cgcttccaat ctgttcggcg acatcctgag
      301 cgacctggcg gcggccgtga cgggtgggct cgggatggcg ccttcgggca atatcaatcc
      361 gaccggtgag ctcccttcca tgttcgaggc ggtgcacggc agcgctcccg acatcgccgg
      421 acagggcatc gcgaatccgg tggcgcagat cctggcgggg gcgatgctgc tcgaacatct
      481 cggggaaacc gttgcggcac aagaggtacg cgcggccgtg gagaaggttc tcgaggaggg
      541 ggccgtgcag acccctgacc tcggcgggaa gtccaccacc gccgaactcg ggtccgcggt
      601 ggtcgccgct ctatcttgaa ccatccgccc ggtgacgtgt caagtcccgg atgtcatgaa
      661 tggtccattc atggtttcgg gtagtacgtg aaggcccctt cgctgcgttt aacgcaaaga
      721 aggggccttc acggtccggt gttcccaatg tctggatgtc gagccgacgg ttgcgaaagc
      781 cactttccca accttcagcg ttgcgaaagt ggctttcgcg acacgtcacc ttgccgtacc
      841 actcgatagt gccgtccccg ccgttgaact tcgcggattc gttcctcccg gcaatccgcc
      901 gattttctcg aagtgacgga aaaacgttgc cacgaaaggg aatctcggcg cgaactccgg
      961 tatgaaagcc cgttcgtcgc acgcgcgccg ctccggggtg tgagtttttg tcggtgccgc
     1021 ggtgcacagt gtcgatcatc ggattcgacg actggaggag tgccgatgtg ctggcattgc
     1081 gacaaccccg gaaagacccg cgaggactac ctcgtcgagg aggtccgtcc gctgatccgc
     1141 aagtacggct ggatggtgca gacggtcgag cgcggaatcg tccaaccggg cttcgcgtac
     1201 acggtcgggc tcaccgacgc cgggcttccg gagctcgtcg tcaccggcct gagagaacga
     1261 agatccggcc agctgctgaa ctatttcgcc cagcaggtgg tccggtcggg gccgccggag
     1321 ccgggtgagg tgctgcccgc ggaggtgggg tggccgtcgt tggaggtcgt cccgctcagt
     1381 tctccaccgg cgcacctgct caccgccgtt ctgctgtacg gcgagaactt ccgcgccctg
     1441 caactggtct acgaggacga gcacggcaat tggccctggg acagggagtt ccgtggcggg
     1501 accggtgggc agccggtgct gggggcacgg ggccgtggct gaatccctaa ggcacagcgg
     1561 gagcttcgcc ctcccgcagg ctggttcccg gggccagccg ttggacggcg tcctccatat
     1621 gggcctccag cagcgaaagc gcggtctcct cgtcgcccgc ccgcagggct tcgatgatgc
     1681 ttgtgtgttc ggtgacccgt tcttcgaccc gctgataggt cccctgcagc gcggtgaggc
     1741 acatccgggt ctcgatcaac agggtccgcg ccatgcgcac gagtcgtttg ctgccggagg
     1801 cggcgatcag cgcctcgtgg aaacggaggt ccgcccagga gagcgcggtc gggtcgtcct
     1861 cgtccgcggc ggcggccatg gcgtgtacgg cctcttcgag ttcggtggcg acccgttccc
     1921 ggtccccgcg caaggcacgc agcatcgcgg ctcgttcgat ggccgagcgt gccgagtaga
     1981 tgtcgtagac gtcgccgggt tcgaggtcga tcacgaacag tccgcggtgc cgctcgctgc
     2041 gcaggagccc ttcggagacg agatgctgca tcgcttcacg cagcggtccc cgcgaaacct
     2101 ggaaccggga ggccaggtcc gtttcaccga gctgggtgcc gggcgggagg gcgccggtca
     2161 tgatcgcgtc ccgcaactgg cgcgcgatga tcccggcggt cgattcccgg ctgaccggct
     2221 cgatatccgg caaggacatg gctcagctgc tcctctgtcc gaacagggcg cccaaggtgc
     2281 ggacgagcgg ggacttcccg gtgagccgca ggccctccca gacggtgacc tggttggcgg
     2341 tcagcaccgg cttgcggatc ctggtttcga gcgtgttgat ctcgccgagc gtccgcatgg
     2401 cggtgtcggg gacgagcagg gcgtcggcgg ccgggtggtc gcggctcacc gcgagttcga
     2461 cgacggcttc cgggctcaga tcgccgacct cggcggcggt gtcgatatcc gcgctgccca
     2521 tcgagaccac ttcgatcccg cccgcgccga ggaactcgac gaacagccgg gcgacgtcgt
     2581 cggggtagct ggcggcgacc gcgacccgcc ggacgccgag cgcccgtgcg gcgttgacga
     2641 aggcgaagga ggtgctcgac gccgggacac cggcgacggc ggccagccgg tcggcctggt
     2701 cgcgggcgcc ttcccagccg tagacgaaac tgccgctggt gcacgcccag accaccgcgt
     2761 ccggttcgtg cttggcgagc agcgcggcgc cgtcggcgag ccggctttcg ctgccgaggt
     2821 ccagtagctc gggcacggcg tggaggtcgg tcccgtagat gtgctcgacc ggcagtttga
     2881 tcccggccat gtccccgccg aggagctgtt ccgcgagcgg gtagtcgtct tcggccgcgt
     2941 gatcggggta gatgaacccg atggtggtcg tctcggacgg cggctcgggt ggggcgaacg
     3001 gcgtgatggg cacggaacct ccggaggggg cagattgtcg acaatcgtaa aggaagaggt
     3061 cagtcgacct cccggagcca cttgccgggc ccgacgatcg gcaggttcat ccgccggagg
     3121 caggcccaca tcgtgagctg gttcgcggtg aggacgggtt tgccgagtgc gctttcgagc
     3181 ggctcgatca gatcgtaggt ggggaggttg gtgcagctga cgaagatggc ttccgcgtcg
     3241 gcgtggtcgg cggcgaggat gcgttcggcg atggtccggt agctgacctt ccagatacca
     3301 ccgcccaggc cgaggtggtc actcgaaacg gtgcggacgc cgagttcggc caggaagtcg
     3361 tgcagcttcc cggtcaggtc gccgtcgtag ggcgtcagca ccgagacccg gtggaggtcg
     3421 agctgatgca ggacctccgc cagcgccccg gacgtggtga cggcgtccgt cgcgcccgcg
     3481 tcgcagatcg ccttggtcag agaacgttcg tagtccacac cgttgacgaa actgccggag
     3541 gtgcacagat aggcgacgac ttcgggctcc acgtggagca cgtccctcgt ggcggcggcg
     3601 agatgcctgc tgtcgctgac gagctgggcc atctccatgc tgacgggcac cggctcgtac
     3661 ggcgtgcgcg ccagatggag ggagacctcc atgggtaccc agcgccacag ctcgcgttcc
     3721 agggcgaggt cgaagggggc gatcacgccg ataccgcgct gcgccaacgg gccttcgaac
     3781 tccagtaagt cgaaatccaa gtctcagcct ccggaaagct tctgctgtca caggtccggt
     3841 gctccggggg tcggtcctcg gattgttgac aatcatacga gccactttta cggtgtcaac
     3901 gtgatcgcct cggagacccc tgtgctggcg gtgctctgcg gagacacgcg cccaccggac
     3961 atgcgcgcta tcgaagccga agcggtggtt cgttacaccg acgcggccgg gttggccgac
     4021 gcgttatccg gcgccgacgc gttcttcgtc tacgacttcc tgtccaccgc cgtcccgggc
     4081 gcctggcatg cggccgaccg gctgcgctgg ctgcacatcg ccagcgcggg cgtcgacccg
     4141 gtgctcttcc ctgggttgca ggagagcgac gtcgtgctca ccaactcgcg tggggtgttc
     4201 gacggggcga tagccgagta cgtgctcggc gtcgttctca cgttcgccaa ggatttcgcc
     4261 cggtcgtggg atctgcagaa gcagcggcaa tggaagcacc gcgagagcga acggatcgcc
     4321 ggccggcggg cgctggtggt cggcaccggg ccgatcggcc ggtcgatcgc gcggatgctg
     4381 cgggcggccg ggctgtcggt ggcgggtgtc ggacgccgtc cccgtgcgga cgatcccgac
     4441 ttcggtgacg tatacgcgtc ttcggagctg tctcggcatc ttcccggagc ggactacgtc
     4501 gtcgcggtcg cgccactgac cgagcagacc aagggcatgt tcgacgccga agccttcgcc
     4561 gcgatgaaac ccggctcgcg gtttgtcaac gtcggccgtg gcgaactggt cgtcacgtcg
     4621 gacctgatcg gcgcgctgcg gaacgggccg ctcggcggcg cggcgctcga cgtcttcgac
     4681 accgaacccc tgcccgccga aagtcctttg tggactatgg agaacgtgct gatctcgccg
     4741 catatgtcgg gcgacttcgt cggctggcgt aatactctgg tagaggtgtt cgcggacaac
     4801 ttccgtcgct ggcgcgcggg ggagccactg cgcaacgtcg tggacaagcg gctcggatac
     4861 gtgccgtcgg agacgcttcg ccaaggttag gggccggatt gaacgacacc aagttgaccg
     4921 cgagcgagct cgtcgccgcg tatgccaccg gagaactgtc gccggtcgag gccacccaga
     4981 acgcgttgcg tgccatcgag gaacgcgacg gcgagaccaa cgccttctgc ctggtcgacg
     5041 ccgatggcgc actcgagcag gcgaaagcgt ccgagattcg gtggcgggac ggtaatccga
     5101 tcggctggct cgacggtgtc ccggcctcga tcaaggacat gttcctgacg cagggctggc
     5161 cgacgctgcg cggttcccgg tgcatcgacc ccgaccagcc ctgggacgtc gacagtccgg
     5221 tcaccgcgcg actgcgcgag aacggcttgg tgctgctggg aaagaccacg acgccggagc
     5281 tggcgtggaa gggcgtcaca gacaacacgc tgaccgggat cacccgcaac ccggtcgacc
     5341 cgtcgacgac ggcgggcggc tccagtggag gcagcgccgc ggccgtcgcg gcggggatgg
     5401 gcgagctctc cgtcggcacc gacggtggcg gctcgatccg gattccggct tcgttctgcg
     5461 gaatcgtcgg tctcaaaccg acacacggcc ggatcccgct gttcccggcg agcccgttcg
     5521 ggccgctttc gcacgccggc ccgatggcgc gttcggtgga cgacacggcg ctgctcctcg
     5581 acgttttggc gatgcccgac taccgcgacc cggccgcgct cgccccgccg gtctcgacct
     5641 accgcgaggc cgtccggcgg gacgtgcgcg gactgatcgc cgcttactcg ccgacactcg
     5701 gctatgtcga cgtcgacccg gaggtcgcgg agatcgtcaa gtcggcggtc cagtcgctcg
     5761 gggacgcggg cctgcacatc gaagaggccg atcccggttt cgcggatccc aagcccgcct
     5821 tcgacatcct gtggtcgaca ggggcggcca agtggctgga caccttcccc gccgggtcgg
     5881 agaccaaggt cgatcccggg ctgcggaagg tctgggagct cggcaagacc ttctcggcga
     5941 gcgactacct cggcgccaac gccgagcgcg ccgcgctggg catcctgatg ggcgagttcc
     6001 acacgcgcta cgacgtgctg atcacgccga ccctgccgat ccccgccttc gaagccgggc
     6061 acgaggtgcc gccgggcagc gggctgagcg gctggccgga ctggacgccg ttcacctacc
     6121 cgttcaacat gacccagcag cccgccatca gcgtgccggc gggccgcacc tccagtggcc
     6181 tcccggtcgg tctgcagatc gtcggcccgc ggcactccga cgacctggtg ctcgcggtcg
     6241 cgaagctcct cgaggaggtc cgcccctggc cgtgacctgc gaaaagggag caagggacct
     6301 ttgctaccac tttcgcgggc gggtgctcag ggctgggcgg cgtgggtctt ccggaccagt
     6361 ccgcgcacct ggccgctgca cagggcgaga caggtggcgg ccacgaccag ggcggcgcac
     6421 gcgagcaggg tcgtgctgac cccgaagtgc tgcgcggccg gtccggccgc catctggccg
     6481 agcggcaggg cgatgaagga accgagcatg tcgtaggagt agacgcgcgc gagtttgtcc
     6541 tcgggcacgt tctcctgcag cgagacgtcc cacgcgacca cgaactgctc gatcgccagg
     6601 ccggagacga acatggccgc gagcagcagc gggagcaagg gcgcctggcc gagaaggatc
     6661 agcggcggcg cttcgaagag gatcaccgcg acaccgacga acagcgcgcg ccgcggctgc
     6721 catcgggcca cgaggatccc gccgacgagc gagccgatcg tctgcgcggc gagggcgaaa
     6781 ccccagccgg agcgtccgaa ggtgctgtcg gcgacaacgg gaccgagcac cgcgatcccg
     6841 ccggcgatga cggcgttcac caccatgaac tgcacgacca cgacccacac ccaggtgcgt
     6901 gaccggaatt cgcgccagcc ttcggcgagt tccgccagcg gacggctgcc ggggacgcgt
     6961 tcccggcggt tgaggcggat gcaccggtac gacagagccg aacccaggaa caggagcgcg
     7021 ttcccggcga gcgcccagcc ggggccgacc gcggtgacca ggatgccgcc gagtccggca
     7081 ccggcgatcc ggccggagtt cgacagcagc ctggccagcg cgttcgcctg cgcgagctgg
     7141 gtggcgggca ccgtcagcgg ggtgagcgac gccgacgcgg gggccgagat cgcggccacc
     7201 gcgccgttga ccacgctcag ggcgaccaat agcgggatcg acgcgaatcc acaaaggaca
     7261 ctcgcggcga tgacggcctg ggtcagcgtg gcggcgacct cggtgccttg caggatcacc
     7321 gaccgcggca gccggtccgc gagcaccccg ccgaacagca acagcaccac gctcgccacc
     7381 gagcgggcgc cgacgacgat gccgatgtcg acggcggaac cggtcaggtc gatcacggcg
     7441 aacgcgagcg cgagcggggc gacggcgttg ccgaactccc cgaacgtgcg gccggcgatc
     7501 agccagcgga agttgtggtg gcgcagtggt tcccgcaggg aggtcacggt cgcctcatct
     7561 cgaacatcgc caccgtcgcg ctgaccggga tcgtgccccg ggtgcggggt ggtttcgcgg
     7621 ccgagtgcag cagagcgctc agttcgcgag cgtgttcgag cgccttctcc caggtctcgc
     7681 ggtcgaccca catctccgcg tcgttgatcg agccgcgttc atccggcaag cggaattcgc
     7741 tgcggcgctt gagttcttcg accatcgccg cgatgagaag ctgctcctcg tccggattct
     7801 tcgaggtgaa ccgcatcccg gactccggat cgtgtcggta gcgtttcgcc agcccgcccc
     7861 ggatccggac ctcctcggcg acgtcgagca gcccggcctc gtgcagccgt cgcacgtgat
     7921 agctgacatt cgcttgtgtc tcaccgagtt cgcgcgcggc ttcggccgcg ctcatcgcga
     7981 caccggtcaa aagcgacaga atgcgcagcc gcaggggatg ggcgaggacg cgaagcccat
     8041 cgaggccggg ggactcggac atgtcacgag tatcggctgc cgggacgtca accgtcaaat
     8101 agtcatttgg gggtttcatt ggccgggaga accggtgcgg tggtcggatg tctgtgctct
     8161 gctggagtca tgcgtacgac gacattgggc aggagcggcc tcgaggtgtc gaggatcgcc
     8221 ttcggcacct ggcagctcgg cggggactgg ggttcgttcg acgaggacac ggcgatcgcc
     8281 gcgatccatc acgcccgcga actcggggtc aacctcttcg acaccgcgca ggcctacggt
     8341 ttcgggaagt ccgaagccat gctgggaaag gcgctgcgcg aggaactcaa gcgcgaccgc
     8401 gacaatctcg tcatcgccac gaagggcggc atcaagccgc gctccgaacg gccacgcgac
     8461 tcccggcgcg agtggctgac gcagggcgtc gaggacagtc ttcgtttcct cgacgtcgac
     8521 cacatcgacc tctaccagat ccactggccc gactccgacg ccccggccga ggaaacggcg
     8581 gggatcctgc aggagttcgt cgacgccggg aagatccggc acgtcggtgt ctcgaactac
     8641 gacgccgccg ggctggccgc cttcgacaag acccgtccgg tggaaaccct gcagccgccg
     8701 tatcacctgt tccgccgcga catcgagacc gaccctctgc cgtacgcgcg cgagaacgac
     8761 atcggtgtgc tcgtgtacag cccgctcggc agcggcttgc tgaccggagc cttcacaccc
     8821 gagacgacgt tcgagaagac cgactggcgg tcccggtcgt cggcgttcac cggagacacc
     8881 ttcctgcgca acctcgccgt ggtcgacagg ctcaaggaat tcgccgcgga caaggggatc
     8941 tcggtcagcc agctcgcgat cgcgtggacg ctcgcccagc ccggggtaca cgtcgcgatc
     9001 gtgggcgcgc gcaaggcggc caacatcgag gccagcctcg ccgccgccga catcgacctg
     9061 tccgcggacg agctcgtgga gatcgatcgc ctcaccgccg acgccgttcc cgtttcggga
     9121 gcgagccccg aaggcgtcgc ctagagcttg aattccgtac cgtccaacgg aagggaggcg
     9181 ccgccggcca gtacggcggc gtgctccggc gaggccgggt cgatcaccgg gttcgtgttg
     9241 ttcagatgcg tgtacaccca ccgtgggccg ggccggagct tcgctaggct gccggtgatc
     9301 ggcagatgcc ccatcgccag ctgggcgccg tcgccgacct cggccgcggt ggcacccgac
     9361 atctcgtccg gtgcgtagaa ggttccgtcc agcagcacca ggcccgcgtc gcgcgtgaag
     9421 tcgtcgaatc cgtccggcca gctcttcagg caaggcgcgt atacgaagac accgccggtc
     9481 cggacgtctt cgatccggta cgccaccacc cacggtccgt cctcagtgga cgaacgtgcg
     9541 tacttcggcc gcttgtcgct cacgggaagc atgctcacgc ggaggccgtc gatggagaca
     9601 tccgacgacg gcagccagtc ccagccaccg tagccgtcga tgatcgaacg tgcggggaac
     9661 tgttcggaca aggcatccag aaccgcctct ggtgcccata ccggaaggcc acccgcctcc
     9721 cgcaacagaa gcaggccgag cgaatggtcg agttcggcgt cggtcagcaa caccccgcgc
     9781 agcgggattt cccgcggacc gggcccggca cgcaagggcg gcgtggtgag gatctgcgcg
     9841 cggatgtccg gtgacacgtt gagcaggtac cagccctcgc cgtccgcgct caccgcgaca
     9901 cagtcctggg tccgcggcgg cgcgtccgag acgcacagcg cgcaggcgca gttccactgc
     9961 gggaaaccgc cgcccgccgc ggtgccgagc aggatcaccc tcatcgcggt gaccgcatca
    10021 cgagttcgtc cgttttcgcc ggtgtggcga gaatgaggtc gaccacgccg cgatgcggtg
    10081 aacgcgagca cacgggatcc gtcgccgcgg cgtcaccggt gagctggaac gcctggcacc
    10141 ggcagccgcc gaagtcgatc gcgcgccgct cgcaggtgcc gcaggtgtcc ggcatccagt
    10201 cctcgccgcg ataagcgttg aaggaagcgg attcgtacca gatccaggcc agcggcttgt
    10261 cccgcacgtt gtcgaattcc agggtctcga tcgccgtcga cgcggggcac ggcagcacgt
    10321 cgccgtcggg cgccaccgtc agttgccgcg cgccccagcc gtacatgcac ggcttcgggt
    10381 actgctcgta atagtcggcg acgacgtaga tgatctccat gcggccgcgc agccgttcgg
    10441 tcgccgcgcg cacgatcggc tcggcctcct cgagttgccg ccgggtcggc atcagggcgt
    10501 cacggttgcg cagggcccag ccgtagtact gcgtattggc cagttcgagc cggtccgcgc
    10561 ccattttctc ggccaggtcg atgattccgg cgagctggtc gtggttctgc cggtgcagga
    10621 cgacgttgac cgaaagcggc agcccggcct tcttgatcag cccggcggcg accagtttcc
    10681 ggtcatgggc gcgcgcaccg gcgagccggt ccgcgcggtc ggccgtcgcg ccctggacgg
    10741 agagctggat atgcgcgatg ccgcgttcga cgagatcgtc caatctggac tccgtcagcc
    10801 cgaggccgga cgtcaccagg ttgacgtagc accccagttt cgtggcgtgt tcgaccagga
    10861 tgggcagatc cggtctggcg agcggctcgc cgccggacat gtgcacctgg agcacgccga
    10921 gctcccgtgc ctgcgaaagc accgagatcc attcctctgt ggacagttcg ccgtcacggg
    10981 cgatcagctc caccggattc gagcagtacg ggcaatgcag cgggcagcga tgggtcagct
    11041 cggccagcat gcccagcggt ggcgcggtgt tcaggtccat tcgacgatcc gccgatctcc
    11101 gagccgggac aggacgtcca ggatttcttc ctcacgaaca ccggtgtagc gctcgcgcag
    11161 cgccgaagcg atcgccgcga cgtcctcgac accgtcgcag agggaaagca cggccgccgc
    11221 cgtgggattc gggacgagca cgccttcggg gaacaggagg acgtgcgttt ccctggtctg
    11281 gtcgtagctc agccggactc cgcgccgcag ccgcggtacc gagcccaggt cgagggtggt
    11341 catggttact ccttggccgc cgcgcgctcg atggcgtcga gcatggacca cagcacgtcg
    11401 gtcttgaacg acagtgcggc gatcgccttc tcctgctgtt cgcgggtgac ggcgtgccgc
    11461 accacgatgt cgagcgttcc cttgccctcg ccggagacct tgtcgatccg gttggtgaaa
    11521 taggcgaggt cttccggtgc gatccacgag tagttcgcca gcatgtcggc gacccgccgc
    11581 tgcatgagat ggccggcgaa catttcggtc agccccgaag cgaccgcttc gagccaaggt
    11641 ttcgtgcggg cgaaggtcac gtaggcgtcg acggcgaacc gtacgccggg cgcgacgtgc
    11701 cgctgatcga gaacctcttc gcggtcgagc ccgaccgcgg tgcacaaccg gagccatcgc
    11761 tcgattccgc cgtccccggc cttcgtcccg tcgtggtaga cgatgcggtc gagccattca
    11821 cggcggatct ccggcagcgg gcagttgctg atgatggccg cgtccttctg cgggagcaca
    11881 cattggtagt accagcggtt cgcggcccag atcttcagct cgtactcgga caggtcgccg
    11941 ttgtgcatcc gcacgtggaa cgggtgtgtt ccccagtagc gatgcgaaag cccgcgcaga
    12001 gccgcgatga actccgacga cgacatgacg gacaccgtgc tgcctccaac ggctcgctga
    12061 tcgggacggc ggcgcggtgg tgggggaggg cccccaccac cggatgctgt ctcagtcctc
    12121 catgcgagcc gcgtaggcgg tgacctccat gggggtttcg tactcgacga agtcgggcgt
    12181 ggtccatacc tcgatggttt cggtcatctt ccgctcctaa cgtccacatg ggatcgaacc
    12241 gggtcgggcc ccgccaccct agaagcgtgc cgccgacttc cgaaggtatt ttgtaaagtt
    12301 tcctacctat ggcggatcgc accgtccgat tcgtcacgct cggcgcacac aacggttaac
    12361 agcccacgtg cccgatagcc cgtccagtgg tgtccgtttc gttatgtggt gtgtttctat
    12421 ccaactcgcg gggctccagg ggtagctgaa ggaggcgtcc catgtcctta cgtcgtattc
    12481 tcgccgccac gttcgccgcg gcgacggccg tgtcgatcgc ggccgtcccg gccacggccg
    12541 ccgaagcgcc gtccgtccag gcgatcaggc agctcgcgag cggcctgaac caggcctggt
    12601 cgatcgactt cctgcctgat ggcaccggcc ttttcacaca gaaggacgcc aagacgatca
    12661 gcaagatcga caaggcgggc aaggtcacca cggtccagac catccccggc gtgagcgtca
    12721 ccgcggaggc cggcctgctc ggcatcgccg tctcgccgaa gtacgccacc gacgagacgg
    12781 tcttcatcta ctacacgacc agctccgaca accgcatcgc caagctgaag ctcggccagc
    12841 cgccgacgcc gatcgtcacc ggcatcccgc gtggctcgca gtaccaccac ggcgggcgga
    12901 tccggttcgg gcccgacggc tacctctacg cggggaccgg cgacggccag aacggcgcca
    12961 acgcgcagaa caagaactcc ctcggcggca aggtcctgcg cgtcaccacc gacggcgcgg
    13021 ccgcgcccgg caacccgttc aacagccgcg tctactccta cggccaccgc aacgtccagg
    13081 ggctgacctg ggcgaacggg cagctgtaca tctccgacat cggcgcgaac aggctcgacg
    13141 agctgaacag gatcgagccc ggcaagaact acggctggcc gacctgcgaa ggcccgtgca
    13201 acacggcggg gatgaccaac ccggtcaagt cctggccgac gtcctcggcg acgccgagcg
    13261 ggctcgccgc gtacaaaggc tcgttgtaca tggcgtcgct caagggcggc acgtacaagc
    13321 tcgacctgaa cggcaacggt ggcaagctct ggaccaacct cggccgcacg cgtgacgcga
    13381 ccgccggccc ggacggccag ctgtacacga tcaccccggg cggcctgtac gtctccgacg
    13441 gcagctagcc ccgggcgcgt ttcgtcctct gaatgcggtg gcccaccgca ttcagaggac
    13501 taaacgcggg gcagggagac cgcgtcttcc agttcgacga gcgcggtgtc caggtgggtc
    13561 aggatgcgct ggagatgcgg gacgctccgg cggcagccgg tgacgccgaa gtcgaggttg
    13621 tccccgttgc tggtcagcgt gatgttcaac gcctgcccgt cgagcagcac cgacgccgga
    13681 tagatgccgt cgagcgcggc gccgttccag tacatctgct tgcgcggccc cggcacgttg
    13741 gagatcacca ggttgaacgg cggtttcgtg ttgttcacga agccggggat cggtgagatg
    13801 ccgagctggg cgacgttgat cccggacagc agcagcgtct gcagcggggt cagctccgag
    13861 aagagcttct tgccgttccg catggacgcg ttgatcgtcg cgagccgcgc ggccggatcg
    13921 gtcagatggg tggcgaggtt gcacagcagc gcgccgatgt tgttccccgc cgcgtccccg
    13981 ctgtccttgc gccgcaagga aaccgggacc atcgcggtga gcggcgcgtc ggggagcgcg
    14041 ttctgttcga tcaggtagtc gcgcagcgcg cccgagcaca tcgcgaggac gacgtcgttg
    14101 cgcgacaccc cggccgcggt cgccaccttg cgcacccggt ccagcgacca cgactgcgcg
    14161 gcgaaccggc gtgccccgcc gatcggcacg ttcagcatcg tcttcggcgc ctgcgccggc
    14221 agcgtgagcg tgtgctcctg gaacgcctcc cgcgccacct tcatcgcggc gggcgcgatc
    14281 ccggcgagct ggttgaccgt cttgccgaag gtgctgagca ccgagggcga cgccttgccg
    14341 ttgcggccgc cgtccggttt ggcgcggcgt ccccacggcg gcgggcagtc gaggtccgcc
    14401 gggtcgtccg acagcgtgcc ctgcagatgc cgcagcgccg agacgccgtc catcagcgcg
    14461 tggtggatct tgctgtagat cgcgaaccgg ccgtcctgca ggccctcgac cagatggatc
    14521 tcccacagcg ggcgatgccg gtcgagcagg gtgctgtgcc agcgcccggt cagctccagc
    14581 agttcgcgga tgcggccggg ctggggcagc gccgaatggc ggaagtggta gtcgagttcg
    14641 aggtcggtgt cggtcgacca ggcgaggtgg cccgcggtgt tgaccggccg ggcgggacgg
    14701 cggcggaaca ccgagcgcat gttgtcggaa tcgagcagtt tccggcggat gtcgcgcagg
    14761 tactcgggcc cggcgtcctc gggtttcttg aacagttgca gtccgccgac gtgcatcgga
    14821 tgttcgcgag tctccacgag aaggaacatc gagtcggtca cgggcatgaa cggcatcgtc
    14881 gggaccacct tccgcgcggc ggcgtgcgga cacgccgggt gccagagtct acgcacaccg
    14941 aaaccaccat ctcacgcttt agggtggctc acatgacgat cccgaccgat ccgcagacgg
    15001 gtgagttccg tcggtccgcc aaccatttcg acgcgcgtgt caccgccgac ggccgcgacg
    15061 gctggccggt ggaggcgggg agataccggc tggtggtcag ccgcgcctgt ccctgggcga
    15121 gccgcgggct ggtcgtccgg cggttgctcg gtctcgagtc cgcgctgagc gtggccgtgg
    15181 ccgatccgat ccaggacgag aagagctggc ggttcaccct cgatcccggt gaccgggacc
    15241 cggtactcgg gatcaagtac ctcgccgagg cctatcacgc ggccgatccg cactacatgg
    15301 gcgggatcag cgttccggcc attgtggaca ttccgagcaa acggctggtg agtaacgact
    15361 atccccagat caccctcgat ctgtccaccg aatggaccag cctccaccgg cccggcgcac
    15421 ccgacctcta cccagagcga ctgcgcggcg agatcgacga cgtcaacgcg ggggtctacg
    15481 ccgacgtcaa cgccgccgtg taccaagccg gtttcgcgac caagcaggcc gcgtacgagg
    15541 acgcctacac ccggcttttc accatgctgg acgtgctttc cgaacggctc gagaagcagc
    15601 gttacctcgt cggtgacacg atcaccgaag cggacatccg gttgttcacc acgctcgtcc
    15661 gcttcgacgc cgtctaccac gggcacttca agtgcaaccg gaacaagctg gccgagatgc
    15721 cggtgctgtg ggcctacgcc cgcgatctct tccaaacgcc gggcttcggt gacaccgtcg
    15781 acttcgacca catcaagcgg cactactacg cggtgcacga gcaggtgaac ccgacgcgga
    15841 tcgtcccctt gggaccggac ctgtccggct ggacgacgcc gcatcaccgg gaacagctgg
    15901 gcgggcgccc gttcggcgac ggcacgccgc cgggaccgcc gcccgaggac gaacggatcg
    15961 gggacacgga tggagtcact gcctgaacgc accgacgtcg tcgtgatcgg cggcggcatc
    16021 atcggggtcg cctgcgcgta ccggctcgcc gccgccgggg tctcggtgct gctcctcgaa
    16081 cgcgacacgc tgggggcggg gtcgacggcg aaggcggcgg gcgggatccg gtcgtcgttc
    16141 accacccggg tcaacatcga gatcgggctt cgcgggctgg cggagtacgc ctccttcgcc
    16201 gagacgtacg ggaccgagat cgacttccgc cgcgacggct atctgtacct gatcaccgac
    16261 ccggcggatc tgcccgaatt cgagcgctgc gccgaactgc agaactccta cggcgtccgc
    16321 agccgtctcg tcgagcccgc cgaggcacgg cggttctccc cgctgatcga caccgaaggc
    16381 gtggtcgcgg cgctgtggtc gccggacgac gccaaggcga ctccggactc cgcggtgcag
    16441 ggctacgcgc gggcggcgcg tgggcacggc gcggtgctga agaccggcgt cgaggtcgtc
    16501 gggatcgaac gcgacggcga cgagatcacc ggcgtccgga cctcggccgg ttccgtgcgg
    16561 acggaagcgg tggtctgtgc cgcgggcgcg tggtcgggac ggatcggcga gctggcgggc
    16621 gtcgagctcc cggtgcggcc gtaccggcgg caggtcgtgt tcaccggacc ggtcgcggac
    16681 ctgcccgggc gagtgccgct gaccatcgag atgccctcgg cgttctactt ccaccgagag
    16741 ggcctcggcc tggcgatgtc cttctgcgac ggtgacggcg accccggctt cgacacccgg
    16801 tatcagccgg gcgagtggct gccgaaactc gccgagatcg ccgcgcgccg ggtgcccgcc
    16861 gtgctcggcg ccgggatccg cggcggctgg gccgggttgt acgaggtgac ccccgatcgc
    16921 aaccagatcg tgggggaaag cgtccacctg tcgcggttct tctacgcgac cgggttttcg
    16981 ggacacgggt tccagatggg cccggccgtg ggggagctcg tgcgggacct ctacctgggg
    17041 cgggtcccgg ccatcgacat caccgggctc gacgtccgcc ggttcgccgg cgaccgggcc
    17101 gtgacgaggg agcacaacat tgtctgagtt cgtcgaagtc accaccgagg ccgaactgcg
    17161 cgagatcctg ccgccgccgc tggagcggac cgcgaacaag gcgcgcccga agctgcacga
    17221 gctggaccgg cagtggctcg cggagtcgcc gttcgtgctg atcgcgacct cggcggccga
    17281 cggcacctgc gacgtctcgc cgaagggcga ccccgccggg ttcaccctgg tgctggacga
    17341 cacgcggatc gccatcccgg agcggccggg caaccggcgc gccgacgggt tccacaacgt
    17401 gctgtcgaat ccgcacgtcg ggctgatcta cctgatcccc ggccgcggcg acacgctgcg
    17461 gatcaacggc cgcgcgcggc tcgtgcgcga ggcaccgttc ttcgacgaca tgatcgtgaa
    17521 gggcaaccgg ccgaagctcg cgctggtggt cgacatcgac gagatcttcc accactgcca
    17581 gaaggcgttc atgcggtcga agctctggtc gccggagagc tggacgcccg aagcgctgcc
    17641 gtcgcgggcg gcgatctcga agaccttcga gcggccggag gactccctgg ccgacctcga
    17701 ggcgtactac gctcccgccg cgtactcggc cggtctgtac tgaggcagcg gctggttgct
    17761 ggatcgttga acgatctggc actatcggcg gggtgcctgc acccaccgga gcccagcatc
    17821 tcgccgacgc gctgaccgct ctggggaccg aagtcgtctt cggtctcccc ggggtgcaca
    17881 acctgccgtt atgggaggcg ctggccgata cggacatccg gctcgtcggg gtccggcacg
    17941 agcagacggc cgggtacgcc gccgacgggt acgcccgcgc cacgggcaag ctcggggtcg
    18001 cgctggtgac cacggggccg ggcgcggcga acaccctcgc cgcggtcggc gaggccatgg
    18061 cgtcggcggc gccggtgctg atcatcgcca ccgacatccc gtccacgctg cggcggcccg
    18121 gagtggtccg cggcgtcctg cacgagacgt cggatcagca ggcgatgttc gcgccggtca
    18181 ccaaggccgg gttcaccgtc acgagcgccg accaggtcgc cgccacgctc caccgcgcgg
    18241 cccggctcgc gctccagccg cagagcgggc cggtctacct cggcatcccc accgacttcc
    18301 tgtccgagcg gacgcccgcg cgccgtccgc cgcgttcgca cgcccggcct gccgagatcc
    18361 cggatctcag tgaggccgag gccatgcttg ccgccgccga ccggccgctg atctgggcgg
    18421 gcggcggcgc gttgcgtgcc gaggcggggg aggcgatcgg gaaactcgcc gaacggctgg
    18481 ccgcgccggt gctcaccacg ttcggcgccc gcgggctcct gtcggtcgat catccttgtc
    18541 tcgccccgaa tccggtgcac gcgcccgagg tcggcgcgct gtgggacgag gccgacgtcg
    18601 tcctcgcgat cggcaccgac ttcgacgggc tgatgacgca gaactggctg atgccgaagc
    18661 cgaagaagct catcgcgatc aacgtcgacc cggacgacgc ggccaagaac taccagccgg
    18721 acatcacgct ggtcggcgac gcccgggtgc tcgtcgaggc gctgaaggtc gaggaacggt
    18781 ccgggatcgc ggcgctcgtc ggcaggctcg ccaaggtctc cgcccgggtc cggcggcgga
    18841 tcaaggagga ggagccgcag gccgcggacc tgctgtccac tttggacgag gtattgccgc
    18901 ccgacgcggt ggtggtcgcg gacatgtgcg tggccgggta ttggatcggc gggttccatc
    18961 gggtccgtgc gccgcgcaag ctcgcgtatc cgatgggctg gggcacgctc ggctacggtt
    19021 tccccgccgc gctcggtgcc gctgccgcgg gcggtggccg cgcgatctgc gtcaccgggg
    19081 acggcggctt cctcttcgac tgcggtgatc tccacacgct ggcgcaggaa cagttgccgg
    19141 tcacgacgat cgtcgtcgac gacggcgggt acgggatgct tcgctacgac caggatcgcg
    19201 ccgggctgcc gcggcgcggc gtcgattggg acagccccga tttcgtcgga ctggcaaggt
    19261 ccttcggcgt gcacgcggat cgcgtctccg ggttcgggcg ggcgttccgg cggctgctcg
    19321 gcgagttcgt cgagtccgac gagccgaacg tactggtcgt ccgcgcgaag atggcgccgc
    19381 cgctcaacac ctcgccgcgc tggtaccgca aggaatcccc gtgaccgggc ttcgggtcgg
    19441 cgtggacatc ggcggcacgt tcaccgatct ctgcgtgctc gacgaaaccg gggtcgtcgc
    19501 cgtcggcaag gtgctgacca cgcacgacga gcccgcccgc gcggtcgagg aaggtctcaa
    19561 aaggacactc gcggacgccg ggctggtcgc gggcgacgtc gagcagttcg tgcacggcac
    19621 caccctggtc acgaacgcgc tgatcgaacg caagggtgcc cgcaccgcgc tgctcgcgac
    19681 cgccggtttc cgtgacgtgc tggagatgcg gcgcgagcac cggtaccaac tctacgacct
    19741 gctcatcgaa ctccccgccc cgttggtccc gcgtcatctg cggttcgacg tccccgagcg
    19801 gatcctcgcc gacggttctg tccacacagg actggatgag gaatacgtcg cacggctggg
    19861 ccgcgagctc gacgcccgcg ggatcgacgc ggtggcgatc tgtttcctgc acgccttcac
    19921 gaatcccgcg cacgaacgcc gcgccgccga ggtgctcgag gaagtggcgc ctcggttgcg
    19981 cgtcgcgctg tcgagcgagg tcgttcccga gatccgcgag ttcgaacgca cgtccaccac
    20041 cgtcgcgaac gtctatgtcc aggacctcac cgaacgctat ctgcgcgacc tggaacggcg
    20101 cttgcacgag tccggagtgc gaccgtcgcc gcacatcatg ctgtccaacg gcgggatcgc
    20161 gaccgtcgac accgccgccc gccatccgat ccgcatcctc gaatccggcc cggcgggtgg
    20221 ggcgctggcc gcgtccgcga tcggggccgc ggccggtgtc gacgatctgc tggccttcga
    20281 catgggcggg acgacggcga agctgtgcat gatctccggc ggcgcgccgc tggtgactca
    20341 cgagttcgaa gtggaccgga agtaccggct gttgccggga tccgggctgc cggtgaaggt
    20401 tccggtcacc gacatgatcg agatcggtgt cggcggcggc tcgatcgcgc gtatcgacgc
    20461 gctcggcctg ctcaccgtcg gcccggattc ggccgggtcc gagcccggcc cggtctgcta
    20521 cggacgaggc ggcacggagc cgaccgtgac cgacgccgac ctcgtgctcg gctacctgga
    20581 tccgggctat ttccttggcg gcggaatgac tttggacgcc gagggcgccc gtgaggcgat
    20641 ccgctcgaag atcgcgggac cgctcggcgt cagcgtcgaa gaggccgctt ggggcattca
    20701 caccagcgtc aacgaggaca tggccaacgc cgcccgtgtc cacgccgtcg agcgcggcaa
    20761 ggatccggcg aagctgccga tgttcacctt cggcggtgcc gggccggtgc acggcgtcgg
    20821 cgtggcacgg gcgctcggcg cgcccgaggt ggtcgcaccg cctgccgccg gggtgctgag
    20881 cgcggcgggt tttctcaccg cgcccctggc cttcgacttc gtccgttcgg ctcgcgcggc
    20941 tgtcctcgat ctctcctggg agcaggtcga cgccttgttc gccgagatgg aggccgaggg
    21001 tacggaactg ctgcggaagt ccggtgtgga cgatgtgacg catcgccgga tcgccgagat
    21061 gcggtattcc gggcagggct acgagatccg cgtgccggtc gagcggggga actggccgga
    21121 gtcgctgatc ggcgcgttca ccgagaccta tcggacgttg taccggcgga ccgggccgga
    21181 cgtcgggatc gaggtgctca actggcgggt cgtctccagc gggccgacgc ccgaggtcac
    21241 gctgaaactc gcgggtgccg aggcgcaggg cgacgcgcgc aaggggagcc ggccggctta
    21301 ctttcccgcg tcgggtggat ttgtcgacac ggcggtgttc gaccggtacg ggctcaagcc
    21361 gggtgatcgc gtcgacgggc ccgccatcgt ggaggaacga gagtccactg tggtcgttcc
    21421 gccgggcgcg cgctgcgtcg tcggcgagga cgccagtctg gtggtggcgg tatgagcgtc
    21481 gacccgattc tggtgggttt gctgggaaac cggctgcatt cgatcctggc ggagcagcaa
    21541 aacgcgctcg tcaacacggc tttctcgtcc gtggtgcggg aatcgctcga cctggcctgc
    21601 gcggtgttcg actcacgcgg cgagatgatc ggccagtccg tcggcgggac ccccggccac
    21661 atcaacgcga tggcgaccgg gatgcaccac ttcgtcgccg cgtatccacc ggagaccttg
    21721 gcaccgggcg acgtgctgct caccaacgac ccgtggcaga ccgccgggca gatcaacgac
    21781 atcaccgtcg cgacgccggt gttcctgcga ggcaggctgg tcgcctggtt cgcttcctgt
    21841 tgccacgccc cggacatcgg cgggcggctg gtctccgccg aggcgcacga ggtcttcgaa
    21901 gaggggctgc gcctgccgat catgaagttc cttcgtgcgg gcgaggtcaa cgcggagctc
    21961 gaactgctga tccgcgcgaa cgtccgcacc ccggaggaga ccatcggcga tctgtacgcc
    22021 caggtc
//
