LOCUS       NZ_LT629789            10816 bp    DNA     circular CON 13-MAY-2024
DEFINITION  Amycolatopsis keratiniphila strain FH 1893 chromosome I.
ACCESSION   NZ_LT629789
VERSION     NZ_LT629789.1
KEYWORDS    RefSeq.
SOURCE      Amycolatopsis keratiniphila
  ORGANISM  Amycolatopsis keratiniphila
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Amycolatopsis; Amycolatopsis japonica group.
REFERENCE   1
  AUTHORS   Varghese,N. and Submissions,S.
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2016) DOE - JOINT GENOME INSTITUTE, LBNL, 2800
            Mitchell Drive, Walnut Creek, CA 94598, 94598, USA
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_900105855.1-RS_2024_05_13
            Annotation Date                   :: 05/13/2024 02:01:53
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,886
            CDSs (total)                      :: 8,813
            Genes (coding)                    :: 8,742
            CDSs (with protein)               :: 8,742
            Genes (RNA)                       :: 73
            rRNAs                             :: 4, 4, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 4, 4 (5S, 16S, 23S)
            tRNAs                             :: 58
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 71
            CDSs (without protein)            :: 71
            Pseudo Genes (ambiguous residues) :: 0 of 71
            Pseudo Genes (frameshifted)       :: 26 of 71
            Pseudo Genes (incomplete)         :: 51 of 71
            Pseudo Genes (internal stop)      :: 1 of 71
            Pseudo Genes (multiple problems)  :: 6 of 71
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 18:07:53
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 3461864
            Orig. end                         :: 3472680
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            LT629789.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..10816
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="18"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..10816
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10816
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:5816](+)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..5816
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     gene            568..2217
                     /locus_tag="BLU53_RS15180"
                     /old_locus_tag="SAMN04489733_3121"
     CDS             568..2217
                     /EC_number="2.7.11.1"
                     /GO_function="GO:0004672 - protein kinase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005157015.1"
                     /locus_tag="BLU53_RS15180"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04489733_3121"
                     /product="serine/threonine-protein kinase"
                     /protein_id="WP_267284187.1"
                     /sec_met_domain="Pkinase (E-value: 3.4e-53, bitscore:
                     179.6, seeds: 54, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIAGHYRLVEQIGSGAMGVVWRAIDVRLERSVAVKQILPQPGVSE
                     AERDNMRQRAMREAKNAARFQHPNAIVVFDIAEHGGDPCLVMEYLNGPSLSAIISDEGT
                     LPLGRVAKIGEQVASALVAAHRAGIVHRDVKPGNILIDEAGTAKITDFGISRAAGDMTL
                     TQTGLIGGTPAYLAPELARGSDPVPSSDVFALGATLYQAIEGQTPYGNSSNQLALLYAA
                     ANGQINPPQQAGAATALLMSLLRTEPTERPTMAEARERLAALAANESGAGTAASPRLFG
                     AGGGRQPAVPETPGHGLPGGDRPPWQRTDKPVPSAAAPPQPTKTHTPTAAFIPMRSPSA
                     PPNTPPRPVAAMSPPPSAAAPMRPSPAKPTDAKRKAVLFAGAGAAVVVIAVIVFLILNS
                     SNGANTQAGGNPGVNPPPGTSAPKSSAPSSSRPSPAGLGKTPSEKITSYSSVGSFVLDF
                     FDTGKIGTSASWNMLTDAAKEVYGSEQAFAEYWSTHKVTSADTARADKGGGNADGSIDM
                     NITLNKGTRPALRVVQVGGQYLIDADTRVLGN"
     gene            2291..2596
                     /locus_tag="BLU53_RS15185"
                     /old_locus_tag="SAMN04489733_3122"
     CDS             2291..2596
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007033523.1"
                     /locus_tag="BLU53_RS15185"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04489733_3122"
                     /product="hypothetical protein"
                     /protein_id="WP_016333002.1"
                     /transl_table=11
                     /translation="MADSGPFGPGQNPRFQEDLVGLDPYDPEARAFAEHLDRIERCGPN
                     FTVEACLDGVSDFADSSNRLGGLRWWVSALVVVLIVLGVMVTAWDIIGRAIAWLAG"
     gene            2616..3038
                     /gene="msrB"
                     /locus_tag="BLU53_RS15190"
                     /old_locus_tag="SAMN04489733_3123"
     CDS             2616..3038
                     /EC_number="1.8.4.12"
                     /GO_function="GO:0033743 - peptide-methionine (R)-S-oxide
                     reductase activity [Evidence IEA]"
                     /GO_process="GO:0006979 - response to oxidative stress
                     [Evidence IEA]"
                     /GO_process="GO:0030091 - protein repair [Evidence IEA]"
                     /codon_start=1
                     /gene="msrB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016333001.1"
                     /locus_tag="BLU53_RS15190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04489733_3123"
                     /product="peptide-methionine (R)-S-oxide reductase MsrB"
                     /protein_id="WP_016333001.1"
                     /transl_table=11
                     /translation="MKPVVGATPRVVKSEQEWREQLSPDEYAVLRQAGTERPFTGEYTD
                     EKTTGVYQCRACGAELFRSETKFDSHCGWPSFYDPADTDAVLLREDTTMGMRRIEVLCK
                     SCHSHLGHVFEGEGYATPTDQRYCINSISLKLVPES"
     gene            3114..4010
                     /locus_tag="BLU53_RS15195"
                     /old_locus_tag="SAMN04489733_3124"
     CDS             3114..4010
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005157012.1"
                     /locus_tag="BLU53_RS15195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04489733_3124"
                     /product="TIGR04222 domain-containing membrane protein"
                     /protein_id="WP_072027897.1"
                     /transl_table=11
                     /translation="MNEPWGISGPVFAWLYGLCAVLPVALAAANEWWLRRDTGARTVPG
                     LYHLAALADGVERVTDTAVAGLIARHSLRPDGRGVLHPVKPAPADPFERAVVSLVPGNG
                     IGLRELRSKMARHEVVRALRADLEQRGLLVAEKHRRMGWQYAIGLSAAVLALGIVRLAN
                     ALPLNRPIGALVVLILGVIGAICLAAWRQWPDRSGRATAAGTLALQYGDWDRGLGRTAA
                     GQVALHGLQAFPDKVVAVTLIRTGGTRARVFAGTASTCGGGGAYIAGSSCGGGGSTCGG
                     GGSSCGGGGGGGGGCGG"
     gene            4091..5011
                     /locus_tag="BLU53_RS15200"
                     /old_locus_tag="SAMN04489733_3125"
     CDS             4091..5011
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016332999.1"
                     /locus_tag="BLU53_RS15200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04489733_3125"
                     /product="TIGR04222 domain-containing membrane protein"
                     /protein_id="WP_072027898.1"
                     /transl_table=11
                     /translation="MEDTWGIPGPTFLAIYGALIVFPVVVGLVWTILAKLAYKAPHVDV
                     SGPQPTVYEFAYLAGGPDRVVDTAIATLVDRGTLRVSSAHQLQLTGPEPADPIEKIVAK
                     GAKPGYNATTRGIRARVRLSEPIQTLAKELEARGLVVVDQTPRIRRVVYFLYLAVLVLG
                     VVRLIAGIAGDRPVGYLIPMLIAAVFATVISRALKNKLPGPRPTGEGARVLHKARSAHG
                     RERKRGIPNGPGYAGGAVLGGAAAAVAFGGLAFYPDDELSAALLPPPIPGGGGSSGGGS
                     SCSGGSSCSGGSSGGGGCGGGGCGG"
     gene            5001..5816
                     /locus_tag="BLU53_RS15205"
                     /old_locus_tag="SAMN04489733_3126"
     CDS             5001..5816
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: DUF692"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007033528.1"
                     /locus_tag="BLU53_RS15205"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04489733_3126"
                     /product="DUF692 domain-containing protein"
                     /protein_id="WP_144024009.1"
                     /sec_met_domain="DUF692 (E-value: 1.1e-81, bitscore: 272.9,
                     seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAADGPGTLGIGIGWRHELDLSIARLPGVDWVEVVAENLHAGHLP
                     ETLLALRDKGMPVLPHAVSLSLGGAEPLDTARVEHLAEVTRELGAPLASDHVCFVRAGG
                     LDSGHLMPLPRTREALDVLVDNVKLTQSIVEVPFALENIAAVLEWPDAEFTESEFLREL
                     TDRTGCLLIVDVANLYANARNLGTDPERFLDEIPWERLAYTHMAGGVERDGVYHDTHAH
                     PVVPEVLDLLRELRRRTEPPGVLLERDDDYPSDTELAAELAALREAVSP"
     gene            5813..6157
                     /locus_tag="BLU53_RS15210"
                     /old_locus_tag="SAMN04489733_3127"
     CDS             5813..6157
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007033529.1"
                     /locus_tag="BLU53_RS15210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04489733_3127"
                     /product="hypothetical protein"
                     /protein_id="WP_072027900.1"
                     /transl_table=11
                     /translation="MTSPRERLAGQQAELLKALLAGGDAPAGFDADRLRIEADVLRNKQ
                     SRLAAYLRPDLAEALGDRFAALFREYATAHPKTDAIRARAYADAFGTWLVERGEIPKPR
                     GRFASWLRRI"
     gene            complement(6177..7523)
                     /locus_tag="BLU53_RS15215"
                     /old_locus_tag="SAMN04489733_3128"
     CDS             complement(6177..7523)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_function="GO:0008410 - CoA-transferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1189: L-carnitine dehydratase/bile acid-inducible"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007033530.1"
                     /locus_tag="BLU53_RS15215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04489733_3128"
                     /product="CoA transferase"
                     /protein_id="WP_072027901.1"
                     /transl_table=11
                     /translation="MDTRVWTTLTGDTLAEDAVEITGPESVLPGTFRVEEAATTSIAAA
                     TLAAGELLRLRGIEPGKVSVDTRHAAASFHSEQYIRVDGEPVPFSAPLSGDYRANDGWV
                     RLHCNYPRHVSAVCWGLGVPATRAAFEKVVAAKSKYEVESAVVGAGGAAAVMRTRDEWL
                     AHKQGQASSALPVADIRTLGTSEPVRLFESDRPLGGVRILDLTHVIAGPVAGRVLAAHG
                     ATVMHIGSAQLPTVPPLAVDTGMGKLSAYVDLETEAGRSRLRKLIARADVVLQGFRPGS
                     LTAKGFSPEAIAELRPGIVVADLSAYGWEGPWARRRGFDSLVQMASGIAEEGGKAAGLD
                     GPGPLPVQALDHATGWLTAAAIMTAVRQAATEGGSRHVRTSLAGTGEWLNSLGRKEAGP
                     VGFDGGEWLEDVDGQLGRVTRVKMAGTLPGSNPQWTEETHVPGSDRAVW"
     gene            complement(7523..8215)
                     /gene="hemQ"
                     /locus_tag="BLU53_RS15220"
                     /old_locus_tag="SAMN04489733_3129"
     CDS             complement(7523..8215)
                     /EC_number="1.3.98.5"
                     /codon_start=1
                     /gene="hemQ"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017983668.1"
                     /locus_tag="BLU53_RS15220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04489733_3129"
                     /product="hydrogen peroxide-dependent heme synthase"
                     /protein_id="WP_063274479.1"
                     /transl_table=11
                     /translation="MARLNYNELNDTIRYTAWSVFRAEQGKLGEDRAKATAETTEYLDA
                     LEAKGVVVRGVYDLSGLRADADYMIWWHAEEIEQVQAAYSGFRHTPLGRASAPVWSQVA
                     LHRPAEFNKSHIPAFLAGEEARKFICVYPFVRSYEWYLLPDDERRKMLADHGKEARDYP
                     DVRANTVASFALGDYEWILAFEADELHRIVDLMRHLRGTEARLHVREEIPFYTGTKVAP
                     AELIGLLP"
     gene            complement(8241..9620)
                     /gene="hemG"
                     /locus_tag="BLU53_RS15225"
                     /old_locus_tag="SAMN04489733_3130"
     CDS             complement(8241..9620)
                     /EC_number="1.3.3.4"
                     /GO_function="GO:0004729 - oxygen-dependent
                     protoporphyrinogen oxidase activity [Evidence IEA]"
                     /GO_process="GO:0006779 - porphyrin-containing compound
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="hemG"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016332996.1"
                     /locus_tag="BLU53_RS15225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04489733_3130"
                     /product="protoporphyrinogen oxidase"
                     /protein_id="WP_072027902.1"
                     /transl_table=11
                     /translation="MSTIAVVGGGISGLTAAYRLRTLLGEDARIVVFEATGSLGGKLRT
                     VELAGERYDVGAEAFLARRPEALALVREVGLGDSLVHPTKARAKIHAGGSVLGLPPGTV
                     MGVPASADAVAGMLSEKGRALVEAEASLPPLELPAEDVPLGPLLRERFGDELVDRLVDP
                     LLGGVYAGGADGLGLRATMPGLASAIDRGAHSLTEGAASLLPASPSTAPVFGTLLGGLG
                     TLIARLAELSRAEIRTGTTVTALDRTPTGWKVDGLDADAVLLAVPAPSARRLLDGVAGV
                     ASSVFAKIELASMAVVALALPPGTALPESSGVLIGAGERDAAGKPFAAKAFTFSSRKWA
                     QYGEGPVLVRGSVGRFGEPGALHADDDELVRVVREDLARLTGVTAEPIDTVVTRWGGGL
                     PQYGTGHLVRVERIERAVAAVPGLAVAGATLHGVGLPACIATADAAARRIAGITPPHEG
                     S"
     gene            complement(9620..10687)
                     /gene="hemE"
                     /locus_tag="BLU53_RS15230"
                     /old_locus_tag="SAMN04489733_3131"
     CDS             complement(9620..10687)
                     /EC_number="4.1.1.37"
                     /GO_function="GO:0004853 - uroporphyrinogen decarboxylase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006779 - porphyrin-containing compound
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="hemE"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005156993.1"
                     /locus_tag="BLU53_RS15230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04489733_3131"
                     /product="uroporphyrinogen decarboxylase"
                     /protein_id="WP_063274481.1"
                     /transl_table=11
                     /translation="MSPSVASPAQTVPAARRALPGAPFLAAARGERPAHTPVWFMRQAG
                     RSLPEYRALREGTSMFEACFDPEMLAEITLQPIRRHGVDAAILFSDIVVPLKAAGLDID
                     IVAGTGPVVAEPIRDAAGVRALPVLEPEQVERVAEGVRLLVGSLGETPLIGFAGAPFTL
                     ASYLIEGGPSRNHEHTKALMHSEPGLWHELAGRLADMAITFLSAQLDAGADAIQLFDSW
                     AGALSERDYREFVLPHSAKVLSAVAGYGVPRIHFGVGTGELLVAMRDAGADVVGVDWRI
                     PLDEAVRRLGGGVVQGNLDPALLHGSWPVIEAEVRRIHAEGRAADGHIFNLGHGVLPGV
                     DPDVLTRVVGLVHEL"
ORIGIN
        1 tcggcatcct ggcgaccacg gtcgcgtccg cgctctcgtt cgctctttcg agggcgctcg
       61 gccgcgacct ggtcacccgg cacctgcatc gggcgaaggt ccgcgcggtc aacgaccggc
      121 tttcggacgg cggggtactg gcgatcacct ccttacggct gatcccgatg gtgccgttcg
      181 ctccgttcag ttacctgtgc ggagtgtcat ccgtccgttt cgccccgtat ctgatcggga
      241 ccgcgctcgg cagcctgccg ggtacggtcg cggtcgtcgt cctcggcgac gcactgaccg
      301 gggaaacacc tcccgcgctg ctgatctgtt acgccgtgtt cgccgcggcg ggggccatcg
      361 ggctggtcaa ggtcttccgg cgcaaggccc ggccgatacc cgaaccgagc ggcgaggaag
      421 aattgcccgc ctccgcaccg gcgagctgac ggggagccga aaccgccgcc cgctacactc
      481 gatcgggtgc gcgggacctg tcaggccgcg tagcgccacc atcacccgga gaatgtgtca
      541 ggagcagtcg ccatcgacac cggtcagctg atcgctgggc actatcgcct ggtcgagcaa
      601 attggtagcg gtgccatggg ggtggtctgg cgtgccatcg atgtccgcct cgagcgctcg
      661 gtggcggtca agcagatcct cccgcagcca ggtgtctccg aggccgaacg cgacaacatg
      721 cgccagcgcg ccatgcgcga ggcgaagaac gcggcccggt tccagcatcc gaacgcgatc
      781 gtggtgttcg acatcgccga gcacggcggc gacccctgcc tggtgatgga gtacctgaac
      841 ggcccgagcc tctcggcgat catctccgac gagggcacgc tgccgctggg gcgcgtcgcg
      901 aagatcggcg agcaggtcgc gtcggcgctg gtcgccgcgc accgcgccgg gatcgtgcac
      961 cgcgacgtca aaccgggcaa catcctgatc gacgaggccg gcaccgcgaa gatcaccgac
     1021 ttcggcatct cccgcgcggc cggcgacatg acgctcaccc agaccggcct gatcggcggc
     1081 accccggcgt acctcgcgcc cgagctggcg cgtggctcgg atccggtgcc cagctccgac
     1141 gtcttcgcgc tcggcgcgac gctctaccag gcgatcgagg gccagacccc gtacgggaac
     1201 agctccaacc agctcgcgct gctgtacgcg gccgcgaacg gccagatcaa cccgccgcag
     1261 caggcgggcg ccgcgacggc gctgctgatg agcctgctgc gcaccgagcc gaccgagcgc
     1321 ccgaccatgg ccgaggccag ggagcgcctc gccgcgctgg cggcgaacga atccggcgcg
     1381 ggcacggccg cttcgccgcg gctgttcgga gcgggcggcg gtagacagcc cgccgtgccc
     1441 gaaacccccg gacacggcct ccccggcggg gaccgcccgc cgtggcagcg gactgacaag
     1501 ccggtcccct ccgccgcggc tcccccgcaa cccaccaaga cgcacacgcc gacggccgcg
     1561 ttcatcccga tgcgctcgcc gtccgccccg ccgaacaccc cgccgcgccc ggtcgccgcg
     1621 atgagcccgc cgccgtcggc ggccgccccg atgcggccgt cgcccgccaa accgaccgac
     1681 gccaagcgca aggccgtcct gttcgcgggc gccggtgccg cggtcgtggt gatcgccgtg
     1741 atcgtgttcc tgatcctgaa ctcgagcaac ggggccaaca cgcaggccgg gggcaacccc
     1801 ggggtgaatc cgccgccggg cacctcggcg cccaagtcga gcgccccgtc ttcgtcgcgg
     1861 ccctcgcccg cgggactggg caagacgccc agcgaaaaga tcacgagcta ctccagcgtg
     1921 ggcagcttcg tcctcgactt cttcgacacg ggcaagatcg gcacgtccgc gagctggaac
     1981 atgctcacgg acgccgcgaa agaggtctac ggttcggagc aggctttcgc cgagtactgg
     2041 agcacccaca aggtcactag cgccgacacc gcccgggcgg acaagggcgg cggcaatgcc
     2101 gacggctcga tcgacatgaa catcacgctc aacaagggaa cacgcccggc gctacgggtc
     2161 gtccaggtcg gcggccagta cctcatcgac gccgacacgc gagtactcgg caactgacgc
     2221 agcgtggcgg cggtgagacc cgcctcgctg gtggtaggac aatcgccgat cgtggcttac
     2281 tgttgccggt atggccgata gcggaccttt cggacctggc cagaatcctc gcttccagga
     2341 ggacctggta ggcctcgacc cgtacgaccc cgaagcccgg gccttcgccg agcatctgga
     2401 ccgcatcgaa cgctgcggcc cgaacttcac cgtggaggcc tgcctcgacg gtgtctccga
     2461 tttcgccgac tccagcaacc gtctgggcgg gctgcgctgg tgggtttcgg cactggtcgt
     2521 ggtcctcatc gtgctcggcg tgatggtcac cgcatgggac atcatcggcc gggccatcgc
     2581 gtggctcgcg gggtaacgtg gaaccggtga aaggcatgaa acccgttgtc ggagccacgc
     2641 cgcgcgtggt caagtccgag caggaatggc gggagcagct cagccccgac gagtacgccg
     2701 tccttcgcca ggcgggcacc gagcgcccct tcaccggtga gtacaccgat gagaagacca
     2761 ccggggtcta ccagtgccga gcctgtggcg ccgaactgtt ccgcagcgaa acgaaattcg
     2821 acagccactg cggctggccg tcgttctacg accccgccga caccgacgca gtcctcctac
     2881 gcgaggacac caccatgggg atgcgccgga tcgaggtgct gtgcaagtcg tgccacagcc
     2941 acctcgggca cgtcttcgaa ggcgagggct acgccacgcc gacggatcag cggtactgca
     3001 tcaactcgat ctcgctgaag ctcgttcccg agtcgtaacc gaccgaagcg aaccaccgcc
     3061 cttcctggcg cgttcccgga tgacaggaac agcgtcgggg agggcggtgt cgtatgaacg
     3121 aaccctgggg gatctccgga ccggttttcg cgtggctgta cgggctctgt gccgtgctgc
     3181 cggtcgcgct cgccgcggcg aacgaatggt ggctgcgccg tgacaccggt gccaggacag
     3241 tgcccggtct ctaccacctg gccgcgctgg cggacggcgt ggagcgggtc accgacaccg
     3301 ccgtcgccgg tctgatcgca aggcactccc tgcggccgga cggacgcggc gtcctgcacc
     3361 cggtcaagcc cgccccggcc gatccgttcg agcgtgctgt cgtttcgctc gtgcccggca
     3421 acgggatcgg cctgcgcgag ctgcgttcga aaatggcccg gcacgaggtc gtccgggcac
     3481 tgcgcgccga tctcgaacag cgtggtctgc tggtcgccga gaaacaccgc cggatgggct
     3541 ggcagtacgc gatcggcttg tccgcggccg tcttggcctt ggggatcgtg cggttggcga
     3601 acgccctacc gctgaaccgg ccgatcggcg ccctcgtggt cctgatcctc ggggtgatcg
     3661 gcgcgatctg cctggccgcg tggcggcaat ggccggacag gtccggccgg gcgaccgccg
     3721 cgggcacact ggcgctccag tacggcgact gggaccgcgg actgggtcgc accgcggccg
     3781 gacaggtggc tcttcacggg cttcaggcct tcccggacaa ggtcgtcgcg gtgacgctga
     3841 tcaggaccgg cggcacgagg gccagggtgt tcgccggtac ggcgagcacc tgcggcggag
     3901 gcggtgcgta catcgccggt tcttcgtgcg gcggcggagg ctccacgtgc gggggcggag
     3961 gttcttcctg cggcggaggt ggcggcggag gtggtggttg cggcggctga accctcgaat
     4021 cacggaacca ccaccggacg gaaaagcgtc cgactacggt aagtgcacct gctcgtgaaa
     4081 ggcccgtgcg atggaagaca cctggggcat ccccggaccc acgtttctgg cgatctatgg
     4141 cgccctgatc gtgttcccgg tggtcgtcgg tctcgtgtgg acgatcctgg ccaaactggc
     4201 ttacaaagcg cctcacgtcg atgtgagcgg cccgcagccg acggtgtacg agttcgctta
     4261 tctcgccggc ggcccggacc gggtggtcga cacggccatc gcgacgctgg tcgaccgcgg
     4321 gaccttgcgg gtcagcagcg cgcatcagct ccagctcacc ggtcccgagc ccgccgaccc
     4381 gatcgagaag atcgtcgcca agggcgccaa gccgggctac aacgccacga cccgcgggat
     4441 ccgtgcacgg gtgcggctgt cagagccgat acagacgctc gccaaggagc tggaggcacg
     4501 agggctggtc gtcgtcgacc agacgccgcg gattcgccgg gtcgtgtact tcctgtacct
     4561 cgccgtgctc gtgctcggtg tcgtccgcct gatcgccggc atcgccggtg accgccccgt
     4621 cggttacctc atcccgatgc tgatcgcggc cgtgttcgcg acggtgatct cccgtgcgct
     4681 caagaacaag ctgccgggtc cgcgtccgac cggcgagggc gcccgggtcc tccacaaggc
     4741 caggtccgcc cacggacggg agcgcaaacg cggcatcccg aacggaccgg gctacgccgg
     4801 cggcgcggtg ctcggcggcg ccgccgcggc ggtcgcgttc ggcgggctcg ccttctaccc
     4861 cgacgacgag ctgagcgcgg ccctgctccc gccgccgatc ccgggcggcg gcggttcttc
     4921 gggtggcggc tcttcgtgca gtggcgggag ctcgtgcagc ggtggcagta gcggcggcgg
     4981 cggttgcggt ggaggcggct gtggcggctg acgggcccgg gacgctcggg atcggcatcg
     5041 gctggcggca cgaactggac ctgtcgatcg cgcggttgcc gggggtcgac tgggtcgagg
     5101 tcgtcgccga gaacctgcac gccgggcatc ttccggaaac cctgctcgcg ttgcgcgaca
     5161 agggaatgcc ggtcctgccg cacgcggtct cgctgtcact gggcggagcc gaaccgctcg
     5221 acacagcgcg cgtcgagcat ctcgcggagg tcacccgcga gctcggcgca ccgctggcga
     5281 gcgaccacgt gtgcttcgtg cgcgcgggcg gcctcgactc gggccatctg atgccgctcc
     5341 cccgcacccg cgaagcactc gacgtcctgg tggacaacgt caaactgacg cagtccatcg
     5401 tggaggtccc gttcgcgctg gagaacatcg cggcggtgct ggaatggccg gacgcggagt
     5461 tcaccgagtc ggagttcctg cgggagctca ccgaccggac cggctgcctg ctgatcgtcg
     5521 acgtggccaa cctgtacgcc aacgcccgca acctcggcac cgatcccgag cggttcctcg
     5581 acgagatccc gtgggagcgc ctggcgtaca cccatatggc gggcggggtc gaacgggacg
     5641 gcgtctatca cgacacgcac gcccatccgg tggtgccgga agtgctggat ctgctgcgcg
     5701 aactgcggcg tcgcaccgaa ccgcccggcg tcctgctgga acgcgacgac gactacccgt
     5761 ccgacaccga actcgcggcg gagctggccg cgctgcggga agcggtctcg ccgtgacgtc
     5821 gccccgggag cggctcgccg ggcagcaggc ggagctgctc aaggcgcttc tcgccggtgg
     5881 cgacgccccg gcgggcttcg acgcggacag gctccgcatc gaggccgacg tcttgcggaa
     5941 caagcaaagc aggctggccg cctaccttcg gccggacctc gccgaggccc ttggtgaccg
     6001 gttcgccgcg ctcttccgcg agtacgcgac ggctcacccg aagaccgacg cgatccgcgc
     6061 gcgggcctac gccgacgctt tcggcacgtg gctcgtggag cgcggcgaga tcccgaaacc
     6121 ccggggccgg ttcgcgagct ggctccgccg catttagtcc tctgaatgcg gcggtttcac
     6181 cagaccgcgc ggtcgctccc cggtacatgc gtctcttccg tccattgtgg attcgagccc
     6241 ggcagggtgc ccgccatctt gacccgggtg acgcggccga gctggccgtc gacgtcttcg
     6301 agccactcgc cgccgtcaaa gccgacaggc ccggcttcct tacgccccaa cgagttcagc
     6361 cactccccgg tcccggcgag cgaggtacgg acatgccggc tgccgccttc ggtggccgcc
     6421 tgacggacgg cggtcatgat cgccgccgcg gtgagccagc cggtcgcgtg gtcgagcgcc
     6481 tgcaccggaa gcggtcccgg gccgtcgagc ccggccgcct tgccgccctc ttcggcgatc
     6541 cccgacgcca tctgcaccag gctgtcgaac ccgcgcctgc gtgcccacgg cccttcccag
     6601 ccgtaggcgg acagatccgc gacgacgatg cccggccgca gctcggcgat cgcttccggg
     6661 gagaaaccct tggcggtcaa cgaacccggc cggaaaccct gcagcacgac gtcggcgcgg
     6721 gcgatcagct tgcgcagccg cgaacgcccg gcttcggtct ccaggtcgac gtacgccgac
     6781 agcttgccca tgccggtgtc gacggccagc ggcggcacgg tcggcagctg cgccgaaccg
     6841 atgtgcatga cggtcgcccc gtgcgcggcg agcacgcggc ccgcgaccgg cccggcgatg
     6901 acgtgggtca ggtccaggat ccgcaccccg cccagcggcc ggtcggactc gaacagccgc
     6961 accggctccg aggtgccgag tgtccggatg tcggcgaccg gcaacgcgct cgacgcctgc
     7021 ccttgcttgt gcgccagcca ctcgtcacgg gtgcgcatca cggcggcggc accgcccgcg
     7081 ccgaccacgg ccgactcgac ctcgtacttc gacttggccg ccacgacctt ctcgaacgcc
     7141 gcccgcgtcg cgggtacgcc gagaccccag cacacggcgg acacgtggcg cgggtagttg
     7201 cagtgcagcc ggacccagcc gtcgttcgcg cggtagtcgc cggacagtgg cgcgctgaac
     7261 ggcaccggct ccccgtcaac ccggatgtac tgctcgctgt ggaacgacgc cgcggcgtgc
     7321 cgggtgtcga ccgagacctt gcccggctcg atccccctca gccgcaacag ttccccggcc
     7381 gcgagcgtcg ccgcggcgat actcgtcgtc gccgcctcct cgacccggaa ggtcccgggc
     7441 agcaccgact cggggccggt gatctcgacg gcgtcttcgg cgagggtgtc gccggtgagc
     7501 gtggtccaga cgcgggtgtc cactagggca gcaggccgat cagctcggcg ggcgccacct
     7561 tcgtcccggt gtagaacggg atctcctcgc gcacgtggag gcgggcctcg gtgccgcgca
     7621 gatgacgcat caggtcgacg atgcggtgca gttcgtcggc ctcgaaggcc aggatccact
     7681 cgtagtcgcc cagcgcgaac gacgcgaccg tgttggcgcg gacgtccggg tagtcgcggg
     7741 cctccttgcc gtggtcggcg agcatcttgc ggcgctcgtc gtccggcagc aggtaccact
     7801 cgtaggaacg cacgaacggg tacacgcaga tgaactttcg ggcctcttca ccggcgagga
     7861 acgccgggat gtggctcttg ttgaactccg ccgggcggtg cagcgcgacc tggctccaca
     7921 ccggcgccga cgcgcggccg agcggggtgt gccggaagcc gctgtacgcc gcctggacct
     7981 gctcgatctc ctcggcgtgc caccagatca tgtagtcggc gtcggcgcgc agcccggaga
     8041 ggtcgtagac accgcggacg acgacgccct tggcctccag cgcgtcgagg tactcggtgg
     8101 tctccgcggt cgccttcgcc cggtcttcgc cgagcttgcc ctgctcggcc cggaataccg
     8161 accaggcggt gtagcggatg gtgtcattga gctcgttgta gttcagccgc gccataccgc
     8221 catcttggca ctgccggtgc tcaggagcct tcgtggggcg gtgtgatccc ggcgatgcgg
     8281 cgggcggcgg cgtcggcggt ggcgatgcag gccgggagcc cgacgccgtg cagtgtcgcg
     8341 cccgccacgg cgagcccggg gacggcggcg acggcgcgtt cgatccgctc gacgcggacg
     8401 aggtgtccgg tgccgtactg cgggagtccg ccaccccatc gggtcaccac ggtgtcgatc
     8461 ggctcggcgg tgacaccggt cagccgggcg aggtcttcgc ggaccacgcg cacgagttcg
     8521 tcgtcatcgg cgtgcagcgc gcccggttcg ccgaagcgcc cgaccgagcc gcgcaccagc
     8581 accggacctt cgccgtactg cgcccacttg cgggaggaga aggtgaacgc cttggcggcg
     8641 aacggcttcc ccgccgcgtc ccgttccccg gcgccgatca gcaccccgga cgattccggc
     8701 agcgcggtcc ccggcgggag cgcgagtgcg accaccgcca tcgacgcgag ttcgatcttg
     8761 gcgaacaccg acgaggcgac tcccgcgaca ccgtcgagca gccgccgcgc cgagggcgcc
     8821 gggacggcga gaaggacggc gtcggcgtcg aggccgtcga ccttccagcc ggtgggggtg
     8881 cggtcgagtg cggtcaccgt ggtgccggtg cggatctcgg cgcgggacag ctccgcgagc
     8941 cgggcgatca gcgtcccgag cccgcccagc agggtgccga agaccggcgc cgtactcggc
     9001 gaggcgggca ggagggaggc ggcgccttcg gtgagcgagt gcgcgccgcg atcgatcgcg
     9061 gaggcgagac cgggcatggt cgcgcgcagg ccgagcccgt ccgctccccc ggcgtacacc
     9121 ccgccgagca gcggatcgac gagccggtcg accagttcgt cgccgaaccg ttcgcgcagc
     9181 agcgggccga gcggcacatc ctccgcgggc aattccagcg gaggcagcga cgcctcggcc
     9241 tcgaccagcg cgcggccctt ctccgacagc atccccgcga ccgcgtcggc cgacgccgga
     9301 acacccatga ccgtgcccgg cggcaggccg agcacggagc cgccggcgtg gatcttggcg
     9361 cgggccttgg tggggtgcac aaggctgtcg ccgagcccga cctcacgcac cagcgcgagc
     9421 gcttcgggac ggcgggcgag gaaggcctcc gcgccgacgt cgtagcgttc cccggcgagt
     9481 tcgaccgtgc ggagcttccc gccgagcgac ccggtcgcct cgaagacgac gatccgggcg
     9541 tcctcgccga gcagggtccg cagccggtac gccgcggtca gtcccgagat accgccaccg
     9601 acgacggcga tcgtgctcat tacagctcgt gcaccagccc gaccacgcgc gtcagaacgt
     9661 ccgggtcgac gccgggcagc acaccgtggc cgaggttgaa gatgtggccg tcggccgcgc
     9721 ggccctcggc gtggatgcgc cgcacttcgg cctcgatgac cggccaggac ccgtgcagca
     9781 gcgccgggtc gaggttgccc tggaccacgc cgccgccgag ccgccggacg gcttcgtcga
     9841 gcgggatgcg ccagtcgacg ccgaccacgt cggcacccgc gtcgcgcatg gccaccagca
     9901 gctcgccggt gccgacgccg aagtggatcc ggggcacgcc gtagcccgcg accgcggaca
     9961 gcaccttcgc cgaatgcggg aggacgaact cgcggtagtc ccgctccgag agcgcgcccg
    10021 cccacgagtc gaacagctgg atcgcgtcgg cccccgcgtc gagctgcgcg gacaggaagg
    10081 tgatcgccat gtccgccagg cgccccgcca gctcgtgcca cagcccgggc tcggagtgca
    10141 tgagcgcctt ggtgtgctcg tggttgcggc tcggcccgcc ctcgatgagg tacgaggcca
    10201 gcgtgaacgg cgcaccggcg aacccgatca gcggcgtctc gcccagcgac ccgaccagca
    10261 gccggacccc ttctgcgacc cgctccacct gctccggctc cagcaccggc agcgcgcgca
    10321 cgcccgcggc gtcgcggatc ggctcggcga cgaccggccc ggtacccgcg acgatgtcga
    10381 tgtcgaggcc cgccgccttg agcgggacca cgatgtcact gaagaggatg gccgcgtcga
    10441 cgccgtgacg gcggatcggc tggagcgtga tctcggcgag catctcgggg tcgaagcacg
    10501 cctcgaacat cgaggtgcct tcgcgcagcg cccggtattc gggcagcgac cggcccgcct
    10561 ggcgcatgaa ccacacgggg gtgtgagccg ggcgttcgcc gcgcgcggcg gccaggaacg
    10621 gcgcaccggg cagggcgcga cgggccgccg ggacggtctg cgcgggagaa gcaactgaag
    10681 gagacatcac ggttcatggt gccatgtgcg ctcggaggcc ttactctcgg cgcgcctgcg
    10741 ccccgaaccg gacgatcgcg tcttacagtc ggttggtgac cgcgatgacg tcagtacccg
    10801 atctcttccg tgaagc
//
