LOCUS       NZ_FNHE01000021        25453 bp    DNA     linear   CON 03-MAY-2024
DEFINITION  Geodermatophilus siccatus strain DSM 45419, whole genome shotgun
            sequence.
ACCESSION   NZ_FNHE01000021
VERSION     NZ_FNHE01000021.1
KEYWORDS    WGS; RefSeq.
SOURCE      Geodermatophilus siccatus
  ORGANISM  Geodermatophilus siccatus
            Bacteria; Actinomycetota; Actinomycetes; Geodermatophilales;
            Geodermatophilaceae; Geodermatophilus.
REFERENCE   1
  AUTHORS   Varghese,N. and Submissions,S.
  TITLE     Direct Submission
  JOURNAL   Submitted (17-OCT-2016) DOE - JOINT GENOME INSTITUTE, LBNL, 2800
            Mitchell Drive, Walnut Creek, CA 94598, 94598, USA
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_900103785.1-RS_2024_05_03
            Annotation Date                   :: 05/03/2024 01:00:42
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 4,951
            CDSs (total)                      :: 4,891
            Genes (coding)                    :: 4,846
            CDSs (with protein)               :: 4,846
            Genes (RNA)                       :: 60
            rRNAs                             :: 2, 4, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 2, 1 (5S, 16S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 48
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 45
            CDSs (without protein)            :: 45
            Pseudo Genes (ambiguous residues) :: 0 of 45
            Pseudo Genes (frameshifted)       :: 11 of 45
            Pseudo Genes (incomplete)         :: 37 of 45
            Pseudo Genes (internal stop)      :: 5 of 45
            Pseudo Genes (multiple problems)  :: 8 of 45
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 16:54:22
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 0
            Orig. end                         :: 25453
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            FNHE01000021.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..25453
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="NAPAA"
                     /region_number="1"
                     /rules="(AMP-binding and TIGR02353)"
                     /tool="antismash"
     cand_cluster    1..25453
                     /SMILES="NC([*])C(=O)O"
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(AMP-binding and TIGR02353)"
                     /kind="single"
                     /product="NAPAA"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..25453
                     /aStool="rule-based-clusters"
                     /category="NRPS"
                     /contig_edge="True"
                     /core_location="[6307:10453](-)"
                     /cutoff="5000"
                     /detection_rule="(AMP-binding and TIGR02353)"
                     /neighbourhood="15000"
                     /product="NAPAA"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(6308..10453)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="5000"
                     /detection_rule="(AMP-binding and TIGR02353)"
                     /neighbourhood="15000"
                     /product="NAPAA"
                     /protocluster_number="1"
     gene            complement(<1..1031)
                     /gene="argC"
                     /locus_tag="BLS21_RS23770"
                     /old_locus_tag="SAMN05660642_04828"
     CDS             complement(<1..1031)
                     /EC_number="1.2.1.38"
                     /GO_function="GO:0003942 -
                     N-acetyl-gamma-glutamyl-phosphate reductase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006592 - ornithine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="argC"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1219: N-acetyl-gamma-glutamyl-phosphate reductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012949068.1"
                     /locus_tag="BLS21_RS23770"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05660642_04828"
                     /product="N-acetyl-gamma-glutamyl-phosphate reductase"
                     /protein_id="WP_091218401.1"
                     /transl_table=11
                     /translation="MSGVRTWTVGVTGATGYAGGEVCRLLAGHPNLALAGVHANSSAGR
                     RLGELQPHLLPFADLEVRPSGAEDLAGYDVVVLALPHGESAAVAARLPEDTLVIDCGAD
                     HRLGDPAAWARWYGGEHAGTWPYGLPELAGQRRKLAGAKRIAVPGCYPTSVTLALAPAL
                     AAGLVEPEVVVVAASGTSGAGKSAKPHLLGSEVMGAVSAYGVGGVHRHTPEMVQNLSQA
                     AGRDVTVSFTPTLVPMSRGILATCSAPLAAGVDEAAARAAYEKAYADEPFVHLLPEGQW
                     PTTAQVLGANTVALQLAVDPDAGRLVVVAAVDNLTKGTGGAAIQCANLALGLPETTGLP
                     VVGV"
     misc_feature    1027..1040
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 19.85"
                     /tool="antismash"
     misc_feature    complement(1028..1041)
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: strong, score: 21.76"
                     /tool="antismash"
     misc_feature    1235..1248
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: medium, score: 21.71"
                     /tool="antismash"
     misc_feature    complement(1236..1249)
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: medium, score: 20.75"
                     /tool="antismash"
     gene            complement(1357..2775)
                     /locus_tag="BLS21_RS23775"
                     /old_locus_tag="SAMN05660642_04829"
     CDS             complement(1357..2775)
                     /GO_function="GO:0008237 - metallopeptidase activity
                     [Evidence IEA]"
                     /GO_function="GO:0008270 - zinc ion binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013592.4"
                     /locus_tag="BLS21_RS23775"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05660642_04829"
                     /product="M1 family aminopeptidase"
                     /protein_id="WP_175479730.1"
                     /transl_table=11
                     /translation="MRAGRRWSTVALACSALVLSGCTSAGLGDADPGADDAEPWPDRPV
                     VDLRFEVAPDLATVAGREVVEFTPDLDTCELVFRSWPNKPATSRAGSSLTVSDVRVDGR
                     DADFLVIAAGAPEGAPAGTLVEVPLADCVSAGQTVTAELTFDLVLGEEVNERVGTSSDA
                     EVAWFATAFPLLAWERGRGWERGPAVPVIGETAVSEDFLLDSMEVVAPSGYEVLGTGAA
                     DGAEDQQDGTTVHRFTAPAVRDVAVAVGELDVAERTIDGVRVRVGLDQRVGEADTEAWL
                     DQVEESNGELVDLLGPFPYDDLWVVVLSAQTSGIEFPGAIQFGDVDPDDRRGLVTHELA
                     HMWFYGLVGNDQGEHPWLDESFATFAQTVADGDEQPFAHLAAEDSPPVGGSMAYWAAEF
                     RRPNSAYYDTVYTLGGAALVEARQQVGEEAFDAALADYVAVNAHSIATPDDVREAFADL
                     PEVLEVLREVGALS"
     misc_feature    2985..3000
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: weak,
                     score: 16.79"
                     /tool="antismash"
     gene            3042..4244
                     /locus_tag="BLS21_RS25440"
                     /old_locus_tag="SAMN05660642_04830"
     CDS             3042..4244
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="BLS21_RS25440"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="SAMN05660642_04830"
                     /product="hypothetical protein"
                     /protein_id="WP_091224298.1"
                     /transl_table=11
                     /translation="MRSSLSTAGRRASVLAAAALVSLATAACGPADLQGGAAGTTGQTD
                     VSSQAAIDQPLSLGDAPTAPSSAVPTPAAPAPTTPAQPQTQAPVAGATGSEVEGTDESA
                     AAAVPTEVVPGAPQAAATADQGRRKRDSSSGRSTSASAPAPAAAPAPVAAAAAPAAAGA
                     STGGSGGTFTDQARRSFTAGNGQTGNYLLYAAGIDPAKPVGLVVYVDGTGEYGVDNPTS
                     SYALGGSSGLVATSRARNMMTLAVESPNQSCECWHTGDTSGYADFLAGLIENQLSKYPV
                     SEVWLSGFSSGAQEITRFLVPRHPELMRLGGGWVVFGGGGPPADGGSAVTAARMAGVRG
                     HWFTGTADTSVPLTASWGAQAGERFYAGRGVVTSSEYPAGVGHALDGRLGRTVGQLIDA
                     S"
     gene            complement(4295..4966)
                     /locus_tag="BLS21_RS23785"
                     /old_locus_tag="SAMN05660642_04831"
     CDS             complement(4295..4966)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF021354.4"
                     /locus_tag="BLS21_RS23785"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05660642_04831"
                     /product="BPL-N domain-containing protein"
                     /protein_id="WP_217636259.1"
                     /transl_table=11
                     /translation="MYRGPASTPGCPEAVAAALRRSRWDLDVRFVGPREDLPLEPDVLA
                     GARLYAQPGGGGLRRAYRKMRRSREAIRQFVGSGGGYLGFCLGGYLAGETPGFGLLPGD
                     TDRFISSPGARPDHDGDSIVTLTWAGRRRQVYFQDGAWFDLDPARGPAEVLATYDNGLP
                     AAVVAPFGRGAVGVVGPHPEASPDWYTDSGLPVPDDLQADLTQDLVDRVMTAGRRADRL
                     G"
     gene            complement(5007..6311)
                     /locus_tag="BLS21_RS23790"
                     /old_locus_tag="SAMN05660642_04832"
     CDS             complement(5007..6311)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF019403.4"
                     /locus_tag="BLS21_RS23790"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05660642_04832"
                     /product="heparan-alpha-glucosaminide N-acetyltransferase
                     domain-containing protein"
                     /protein_id="WP_139177274.1"
                     /transl_table=11
                     /translation="MTASRQSSLPHACEPAPSGDVSGTPSSTAPGLRPSARLVGIDAAR
                     GIALFGMMAVHNITAVDDDGEVSLAWTLAAGKSAALFALLAGVGVAFATGRRQRPTART
                     WPGYAAALLVRALIIGGVGLLLGAVVPADFASVILPYYALLFVFAIPLLTLSSRALIAL
                     AATITVVMPVLSHWLRSGTEVRDTVPNLAFGDLVSAPGQVLRELALTGVYPALSWMAYL
                     CVGMAVGRALLTSRRTVVLITLTGAGLAVAAQTISWFLLDVLGGRAELEAVASRSMTSG
                     ELAEVMGVGWTGTTPTDTGWWLATLAPHSTTPLDLAFTIGLGLVVLGVCILVGRATTAL
                     LRPLAAAGSMTLTLYSLHLLLLSWSVMPDGGTGLLIQTVLVLAFALVWGRYHARGPLEE
                     VVAQATGAVRRRVRSMTEPRREVLVLDDDGRVRAP"
     gene            complement(6308..10453)
                     /locus_tag="BLS21_RS23795"
                     /old_locus_tag="SAMN05660642_04833"
     CDS             complement(6308..10453)
                     /GO_function="GO:1904091 - non-ribosomal peptide synthetase
                     activity [Evidence IEA]"
                     /NRPS_PKS="Domain: AMP-binding (62-451). E-value: 7e-104.
                     Score: 339.6. Matches aSDomain:
                     nrpspksdomains_BLS21_RS23795_AMP-binding.1"
                     /NRPS_PKS="Domain: PCP (564-636). E-value: 3.2e-14. Score:
                     44.9. Matches aSDomain: nrpspksdomains_BLS21_RS23795_PCP.1"
                     /NRPS_PKS="Domain: TIGR02353 (682-1354). E-value: 2.8e-179.
                     Score: 589.5. Matches aSDomain:
                     nrpspksdomains_BLS21_RS23795_TIGR02353.1"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) NAPAA:
                     TIGR02353"
                     /gene_functions="biosynthetic (rule-based-clusters) NAPAA:
                     AMP-binding"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR02353.1"
                     /locus_tag="BLS21_RS23795"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05660642_04833"
                     /product="Pls/PosA family non-ribosomal peptide synthetase"
                     /protein_id="WP_217636260.1"
                     /sec_met_domain="AMP-binding (E-value: 6.3e-111, bitscore:
                     361.6, seeds: 400, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 1.9e-13, bitscore:
                     41.6, seeds: 164, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR02353 (E-value: 1.2e-179, bitscore:
                     589.5, seeds: 6, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTHSDDWDFFSTFAGDVEPQAPTTAPGYDMRDNTATSYRLHDNF
                     VAEISGQRSLVTRLSRFFEHTCDQRPSATALECEGERVSYADLDQRANRLANLLMARGA
                     RAGVRVGILLHRSVSTYVALLAVTKTEATFVPIDPEAPADRLQYIAEDSSLSMLVTHTS
                     FAASCVALPCESLYLDELGPELAVQSSSRPGIESDGDPVCYIIYTSGSSGRPKGVEVNQ
                     SSICNFVGIVPSLYGVESTDRVYQGMTIAFDFSIEEIWPTWAVGATLVAGPTDGRRVGS
                     GLADFLEDNEITMIYCVPTVLATLDRTLPLIRTVNVGGEACPRELVDRWGPGRRILNTY
                     GPTETTVTCTMAELRPGKPVTIGRPLPTYRVTLLDDDRKPVPAGQVGEICVGGPGVARG
                     YVNRPDLTADRFIPDPRGIPGERIYRTGDLGRFLPDGELEYLGRADSEVKVRGHRVDLQ
                     EIESVLLEHPQVTGAVVTLLASPDTGGDLAGYVILRDAGAADAVIPELHEQLVAQMPPY
                     MVPSYLDAVTSIPMLPSGKADRGRLPAPTRPRLIRTDREHEPPATPAEAWIAGLWEEML
                     NLPAGAVSVEANFFEALGGHSLVAANVVSAMRESDLGSGLSILDFYKHPTVRDLATFLE
                     DGTAGPSDEPVTLEPREPRPEPPSRERVLGFGTAQVSILYAIILLFLLPVGVLYGLNDG
                     QPSLALVLQLAVALPAVYLLARWVLPVVGARLLSRGLRAGDHPLWGGMHLRVWTVQKLM
                     SISPLTVLSGSPWAVTYLRLAGAQIDDEAHIGTANVSLPSMLRVGRGATIGYGTQLHAH
                     RIAEGILTIGPVTVGAGAVVGSESVLECDSEVGENAILSDQSLLPSRRIVPAGETWAGS
                     PARPAPGSMDPVVELMAACDEAPRTWSSRLLAGFAGGVLLLELLPFMILLPVVAVVWWV
                     LLSFGTAAGLLATALSGPLFVAASCALILGARRLVLPATPEGVHHLRSQLGLEKWLGDK
                     LLEQSLLFNNTMYSTLYTPMWLRALGTRVGKGAEVSTIANIDPDLLTVGEGSFVADMAS
                     VGSATYANGHVAFRRTEIGSRAFVGNAAFVPSGSHLGDGSLIGVRSVPPTAGTEAGTSW
                     LGSPPFFLPRREVFEEFTEADTYAPSRRQVRARYAIEALRIVLPSSLLAVATFVTLYGL
                     SALALSWNTVATVLLAPLVALTSSVLVVVLVAALKWAVVGRYRPRVRPLWSGFVRRTEF
                     VTGIYEAAAVPALLTFLTGTPLLGPALRLFGSRVGRRTLVDTTYLTEFDLVTIGDDVSV
                     GANASLQTHLFEDRVMKMDHVILRDRATIGDKAVVLYGSVVEEDATLSAMSLAMKGEVL
                     PRETTWCGIPAQKVGRAPTAAPARDRRRASAGATGARR"
     aSDomain        complement(6392..8407)
                     /aSDomain="TIGR02353"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_BLS21_RS23795_TIGR02353.1"
                     /evalue="2.80E-179"
                     /label="BLS21_RS23795_TIGR02353.1"
                     /locus_tag="BLS21_RS23795"
                     /protein_end="1354"
                     /protein_start="682"
                     /score="589.5"
                     /tool="antismash"
                     /translation="LPVGVLYGLNDGQPSLALVLQLAVALPAVYLLARWVLPVVGARLL
                     SRGLRAGDHPLWGGMHLRVWTVQKLMSISPLTVLSGSPWAVTYLRLAGAQIDDEAHIGT
                     ANVSLPSMLRVGRGATIGYGTQLHAHRIAEGILTIGPVTVGAGAVVGSESVLECDSEVG
                     ENAILSDQSLLPSRRIVPAGETWAGSPARPAPGSMDPVVELMAACDEAPRTWSSRLLAG
                     FAGGVLLLELLPFMILLPVVAVVWWVLLSFGTAAGLLATALSGPLFVAASCALILGARR
                     LVLPATPEGVHHLRSQLGLEKWLGDKLLEQSLLFNNTMYSTLYTPMWLRALGTRVGKGA
                     EVSTIANIDPDLLTVGEGSFVADMASVGSATYANGHVAFRRTEIGSRAFVGNAAFVPSG
                     SHLGDGSLIGVRSVPPTAGTEAGTSWLGSPPFFLPRREVFEEFTEADTYAPSRRQVRAR
                     YAIEALRIVLPSSLLAVATFVTLYGLSALALSWNTVATVLLAPLVALTSSVLVVVLVAA
                     LKWAVVGRYRPRVRPLWSGFVRRTEFVTGIYEAAAVPALLTFLTGTPLLGPALRLFGSR
                     VGRRTLVDTTYLTEFDLVTIGDDVSVGANASLQTHLFEDRVMKMDHVILRDRATIGDKA
                     VVLYGSVVEEDATLSAMSLAMKGEVLPRETTWCGIPA"
     aSModule        complement(6392..10267)
                     /complete
                     /domains="nrpspksdomains_BLS21_RS23795_AMP-binding.1"
                     /domains="nrpspksdomains_BLS21_RS23795_PCP.1"
                     /domains="nrpspksdomains_BLS21_RS23795_TIGR02353.1"
                     /locus_tags="BLS21_RS23795"
                     /monomer_pairings="X -> X"
                     /starter_module
                     /tool="antismash"
                     /type="nrps"
     aSDomain        complement(8546..8761)
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_BLS21_RS23795_PCP.1"
                     /evalue="3.20E-14"
                     /label="BLS21_RS23795_PCP.1"
                     /locus_tag="BLS21_RS23795"
                     /protein_end="636"
                     /protein_start="564"
                     /score="44.9"
                     /tool="antismash"
                     /translation="EAWIAGLWEEMLNLPAGAVSVEANFFEALGGHSLVAANVVSAMRE
                     SDLGSGLSILDFYKHPTVRDLATFLED"
     CDS_motif       complement(9071..9136)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_BLS21_RS23795_0004"
                     /evalue="1.00E-09"
                     /label="NRPS-A_a8"
                     /locus_tag="BLS21_RS23795"
                     /protein_end="461"
                     /protein_start="439"
                     /score="30.5"
                     /tool="antismash"
                     /translation="YLGRADSEVKVRGHRVDLQEIE"
     aSDomain        complement(9101..10267)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_BLS21_RS23795_AMP-binding.1"
                     /evalue="7.00E-104"
                     /label="BLS21_RS23795_AMP-binding.1"
                     /locus_tag="BLS21_RS23795"
                     /protein_end="451"
                     /protein_start="62"
                     /score="339.6"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="FEHTCDQRPSATALECEGERVSYADLDQRANRLANLLMARGARAG
                     VRVGILLHRSVSTYVALLAVTKTEATFVPIDPEAPADRLQYIAEDSSLSMLVTHTSFAA
                     SCVALPCESLYLDELGPELAVQSSSRPGIESDGDPVCYIIYTSGSSGRPKGVEVNQSSI
                     CNFVGIVPSLYGVESTDRVYQGMTIAFDFSIEEIWPTWAVGATLVAGPTDGRRVGSGLA
                     DFLEDNEITMIYCVPTVLATLDRTLPLIRTVNVGGEACPRELVDRWGPGRRILNTYGPT
                     ETTVTCTMAELRPGKPVTIGRPLPTYRVTLLDDDRKPVPAGQVGEICVGGPGVARGYVN
                     RPDLTADRFIPDPRGIPGERIYRTGDLGRFLPDGELEYLGRADSEVKVR"
     CDS_motif       complement(9221..9310)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_BLS21_RS23795_0003"
                     /evalue="2.20E-17"
                     /label="NRPS-A_a6"
                     /locus_tag="BLS21_RS23795"
                     /protein_end="411"
                     /protein_start="381"
                     /score="55.1"
                     /tool="antismash"
                     /translation="PAGQVGEICVGGPGVARGYVNRPDLTADRF"
     CDS_motif       complement(9407..9436)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_BLS21_RS23795_0002"
                     /evalue="2.60E-02"
                     /label="NRPS-A_a5"
                     /locus_tag="BLS21_RS23795"
                     /protein_end="349"
                     /protein_start="339"
                     /score="7.6"
                     /tool="antismash"
                     /translation="YGPTETTVTC"
     CDS_motif       complement(9791..9847)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_BLS21_RS23795_0001"
                     /evalue="1.60E-07"
                     /label="NRPS-A_a3"
                     /locus_tag="BLS21_RS23795"
                     /protein_end="221"
                     /protein_start="202"
                     /score="23.6"
                     /tool="antismash"
                     /translation="CYIIYTSGSSGRPKGVEVN"
     misc_feature    10494..10511
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 14.69"
                     /tool="antismash"
     misc_feature    complement(10574..10587)
                     /note="TFBS match to PsrA, Oleic acid responsive regulator,
                     confidence: weak, score: 19.27"
                     /tool="antismash"
     gene            10804..11460
                     /locus_tag="BLS21_RS23800"
                     /old_locus_tag="SAMN05660642_04834"
     CDS             10804..11460
                     /GO_function="GO:0000287 - magnesium ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0008897 - holo-[acyl-carrier-protein]
                     synthase activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1012: 4'-phosphopantetheinyl transferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF013786.4"
                     /locus_tag="BLS21_RS23800"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05660642_04834"
                     /product="4'-phosphopantetheinyl transferase superfamily
                     protein"
                     /protein_id="WP_217636261.1"
                     /transl_table=11
                     /translation="MLRVGGEHLLTPRERRRAGALRHRADRDAHVAAHLLVRHCAAALT
                     GRPVEALELVQECAECGSTEHGRPSIAGLPELHVSLAHTRGAVAAGADRRPIGVDVEGA
                     RTRDLDPAVLTSTLTAAETARVRSASDPPAAFLRHWVRKECLVKLGVVTLDELSGVELD
                     PTTEQDVEGGRTRSRFGPLHLLDWFDPTLDVAVAAAAHGPPVVGSARTWAPRRPT"
     gene            11661..12257
                     /locus_tag="BLS21_RS23805"
                     /old_locus_tag="SAMN05660642_04835"
     CDS             11661..12257
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF016424.4"
                     /locus_tag="BLS21_RS23805"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05660642_04835"
                     /product="TPM domain-containing protein"
                     /protein_id="WP_091224304.1"
                     /transl_table=11
                     /translation="MRRPVTVLGALALVLAGAGTASAEPPLEVTEQITDAAGLLGTGAP
                     AAEQAVADLAAEDDLDLYAVLVPSFDGADPGEWAQDTARQSGLDETDVLLAVAAGESAY
                     EYGYWVADDFPLSEVDLDRAVTAEVEPRLAAGDRSGAVVALASQLQDLAATEEEAAQQE
                     APWSASTIILIIGGVAVVLLAAHLLSRRRSSTTRS"
     gene            12511..12765
                     /locus_tag="BLS21_RS24830"
                     /old_locus_tag="SAMN05660642_04836"
     CDS             12511..12765
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="BLS21_RS24830"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="SAMN05660642_04836"
                     /product="hypothetical protein"
                     /protein_id="WP_139177275.1"
                     /transl_table=11
                     /translation="MSLAAPHDPAFCAGTGCSRHHPSNHHMRAWPKVWREYYGYSDRMC
                     SHGVGHPDPDDVVHLQALGEVRTEHACDGCCIAPLSTSA"
     gene            complement(12778..13614)
                     /locus_tag="BLS21_RS23810"
                     /old_locus_tag="SAMN05660642_04837"
     CDS             complement(12778..13614)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014374271.1"
                     /locus_tag="BLS21_RS23810"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05660642_04837"
                     /product="hypothetical protein"
                     /protein_id="WP_245700727.1"
                     /transl_table=11
                     /translation="MWVVGGLVAWLLLAFALAVVVGRGIRIADARSVDPLTTPEPLADL
                     RLRTPRRRVPLPPVGIGLAATAVLLETVGYVGRLTGATGPVARALSMDAPFSAPRTFVA
                     ALFAVAAVAAVAGAARVPHRRAWWLAVGLVCGGIAVVKAGGTVHVEAMRALSSAIGETG
                     AVVVSVALVATVLAVLAVVSRDERRDRRRVLTCLAGYAGASVGLSGVSAVAAGQWAVTA
                     TYLEESGEALAGVAVLVAVLVGVAPRLVLPASWVLRREADAEPLAVPGAVRDRVSG"
     gene            complement(13689..13886)
                     /locus_tag="BLS21_RS24835"
                     /old_locus_tag="SAMN05660642_04838"
     CDS             complement(13689..13886)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="BLS21_RS24835"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="SAMN05660642_04838"
                     /product="hypothetical protein"
                     /protein_id="WP_139177276.1"
                     /transl_table=11
                     /translation="METADAGRTEALVIGVLVVCALVALGAAVVLGRGIRPADARARAE
                     RLFTRADLPAAFQPGVSARR"
     misc_feature    13894..13907
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 19.14"
                     /tool="antismash"
     gene            14410..15324
                     /locus_tag="BLS21_RS23815"
                     /old_locus_tag="SAMN05660642_04839"
     CDS             14410..15324
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="BLS21_RS23815"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="SAMN05660642_04839"
                     /product="hypothetical protein"
                     /protein_id="WP_139177277.1"
                     /transl_table=11
                     /translation="MRYPGDIVAAVQPEFEAALWRARAMEQQTALLVAGRPRRVLLEML
                     FSVIVYLLGVLDSVECLAAAGRGARKTRECSRVHRIEKALEIAQSELTRLQEFADQAAV
                     RAALKHYVQGLFIGGGAVVASAWTASQVHMFEQAPTLDLVRAIAAGGLGAIISVLIRIS
                     RGQRLDVDTTQEPFLTCLAGSSRTVIGGALGVALYVLLKAEFIPLEIPAASDAAAPYFF
                     TAIAFLAGFSERWAQDTIVRSTPLATSASGSPIPSTSTPCASAPTESAAGGGTGAGLVQ
                     TTSLPVIAPPTPDGTDLARRPPD"
     gene            complement(15354..16094)
                     /locus_tag="BLS21_RS23820"
                     /old_locus_tag="SAMN05660642_04840"
     CDS             complement(15354..16094)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012948429.1"
                     /locus_tag="BLS21_RS23820"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05660642_04840"
                     /product="VOC family protein"
                     /protein_id="WP_091224310.1"
                     /transl_table=11
                     /translation="MPCHLVALSFDADDPLGLARFWAGLLGWEMADESHVGLALLPSDD
                     TGFRIRFLPTQEQKAGQNRMHLDLTSTSREDQQQTVARALGLGARHIDVGQRPEEGHVV
                     LADPEGNEFCVIEPGNRFLADCGFVGALACDGSQEVGYFWRDALGWPLVWDQDQETAIR
                     SPHGGPKITWGGPPLMPKTGKNRLHLDLAPPATGDQQAEVDRLVSLGATRIDIGQGEVG
                     WVVLADPDGNEFCVLCPDSATGSG"
     gene            complement(16239..17558)
                     /locus_tag="BLS21_RS23825"
                     /old_locus_tag="SAMN05660642_04841"
     CDS             complement(16239..17558)
                     /EC_number="1.1.1.-"
                     /GO_function="GO:0016616 - oxidoreductase activity, acting
                     on the CH-OH group of donors, NAD or NADP as acceptor
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1152: nucleotide sugar dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014374269.1"
                     /locus_tag="BLS21_RS23825"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05660642_04841"
                     /product="UDP-glucose/GDP-mannose dehydrogenase family
                     protein"
                     /protein_id="WP_091224312.1"
                     /transl_table=11
                     /translation="MRISVIGCGYLGAVHAASMAELGHEVVGIDVDQRKVAALCAGRAP
                     FYEPDFAELLQHSLASGRLSFSTDVHDAAGAQVHFVCVGTPQKHGEYAADLRFVQAAAE
                     SLLQVLEPGELVVGKSTVPVGTAAELARMFGEKVPGSLLAWNPEFLREGFAVRDTLHPD
                     RLVYGVPDGPDAESIVATLDEVYAPIVATGTPKVVTDYATAEMVKTAANSFLATKISFI
                     NAMAELCEATGADVKQLADAIGFDDRIGRKFLNAGLGFGGGCLPKDIRAFMARAGELGA
                     DQALTFLREVDNINMRRRIRMVELAREVCDGSLLGKHIAVLGAAFKPDSDDIRDSPALN
                     VAAQLQLQGAVVTVTDPAAIENSRRQWPQLDYAATPEEAAERADAVLVLTEWRQYRELD
                     PVAFGEVVAQKRVLDGRNALDREAWTAAGWTYRALGRRAG"
     gene            17841..18005
                     /locus_tag="BLS21_RS25445"
                     /old_locus_tag="SAMN05660642_04842"
     CDS             17841..18005
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="BLS21_RS25445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="SAMN05660642_04842"
                     /product="hypothetical protein"
                     /protein_id="WP_175479731.1"
                     /transl_table=11
                     /translation="MWTTVVVRVLLAVPVAVLLGRIIQRADDRELGSLDRPSRGDDLPS
                     HPHEAGSLR"
     gene            18092..19168
                     /locus_tag="BLS21_RS23830"
                     /old_locus_tag="SAMN05660642_04843"
     CDS             18092..19168
                     /GO_process="GO:0070726 - cell wall assembly [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014374277.1"
                     /locus_tag="BLS21_RS23830"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05660642_04843"
                     /product="LCP family protein"
                     /protein_id="WP_245700726.1"
                     /transl_table=11
                     /translation="MSGATGTAAPDRHTDEGAEPSSRRSRTVRRVLISLGVLGSVVAMV
                     VGGALWFLTDRYAGNMERVSDAFASLDEGARPAPATPAQQAGEEPVTFLLVGSDTRATA
                     EEGIAAGGRSDAIMIARFSADRQHAQLISVPRDSWVDVPGHGMDKVNAAYAYGGPALLI
                     RTVEQLTDVRIDHYVAIDFEGLIQVTDDLGGVDVVVAETTSNGPYTFPAGVNHLDGDQA
                     RWYLGQRYGLPGGDFDRVRRQQQYLQAMFGKLFSSDTFTDPGRLDAALLAVTSAVAVDE
                     QLGNTEILSLAYSLRGLTPDDVDFFTAPVLGTGTEGAASVVYLDGVAGERMWGYLQTDS
                     LSQNAEEFSTQALPDVPR"
     gene            19268..19540
                     /locus_tag="BLS21_RS23835"
                     /old_locus_tag="SAMN05660642_04844"
     CDS             19268..19540
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="BLS21_RS23835"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="SAMN05660642_04844"
                     /product="hypothetical protein"
                     /protein_id="WP_091224314.1"
                     /transl_table=11
                     /translation="MTTQPSAANVPPDNETSSSSPDGGMPVGAADAEADARRSGAGDQD
                     ERPSNVGEGLLLDVDPGQETDGGVPVGRADAEADRMGSAEGDDRT"
     gene            19629..20780
                     /locus_tag="BLS21_RS23840"
                     /old_locus_tag="SAMN05660642_04845"
     CDS             19629..20780
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) MGT"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1062: glycosyltransferase, MGT family"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:TIGR01426.2"
                     /locus_tag="BLS21_RS23840"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05660642_04845"
                     /product="macrolide family glycosyltransferase"
                     /protein_id="WP_217636262.1"
                     /sec_met_domain="MGT (E-value: 2.7e-52, bitscore: 169.1,
                     seeds: 193, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MALAGHGHVTPTLPLVEELVRRGHHVAYATAADFAEVVTGAGAQW
                     VQLPPMAPFRPPAQVGPDLIASWFRHYFAAMRATYPVLHEYCRTARPDAVSYDVTNWPA
                     RLVAHHLGIPAVRLIPNLAENHAYSLDDRLTEGLDPDHPQMTALAEDCVRFSTEYGVDL
                     DVAGTMDVPEALNLVFIPREFQPAGDSFDERFHFLGPLLGRREQREPWSPPDPHAPVLY
                     ISLGTIFTDNPAFYRTCIEAFGDGSCQVAMTVGDLDPAAIGPVPPGIDVRPRFPQPAVL
                     RHARAFISHAGMNSTMEALYYGVPLVTLPQMPEQAANADRVVELGLGERLATDTLTPDA
                     LRQAVSRVTTDEQVRANLERMRRAIHDAGGAERGAALIEDHLA"
     misc_feature    19642..19657
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: weak,
                     score: 16.86"
                     /tool="antismash"
     misc_feature    complement(20890..20905)
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: strong,
                     score: 19.52"
                     /tool="antismash"
     misc_feature    complement(20901..20916)
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: strong,
                     score: 19.52"
                     /tool="antismash"
     gene            21049..22035
                     /locus_tag="BLS21_RS23845"
                     /old_locus_tag="SAMN05660642_04846"
     CDS             21049..22035
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="BLS21_RS23845"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="SAMN05660642_04846"
                     /product="hypothetical protein"
                     /protein_id="WP_139177278.1"
                     /transl_table=11
                     /translation="MYKKRLRETGDPEVAVRRQVSEQLGINQTTLRRWIQREAAVSGDP
                     AGAAAPASRPVWWRRPVTWVAGVIGTALTATAVTAVGSRLEEVVTKATETGPPVSVDQV
                     MEFRSDMYGDSVAFARGASFTDADLAELNQIDQDFGGMDSVEWLESRGGVAPDIVLIQL
                     ALSGNRTGSVRITNLEVHPDCSAPLDGLWFEDPPAGADDSIRMHFDLDDSNPVAKVASM
                     DGSPTGEPEDYFPARTISLKQGEQQVIIVSASTEEKYCSFFLDMTVLEGDETSTHRITM
                     PAGSPFEVTASLPLDQYEEVYLGGVVCYPWVKAGNAFFNGDWEHQCS"
     misc_feature    21095..21110
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 19.77"
                     /tool="antismash"
     gene            22162..22401
                     /locus_tag="BLS21_RS23850"
                     /old_locus_tag="SAMN05660642_04847"
     CDS             22162..22401
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013607.4"
                     /locus_tag="BLS21_RS23850"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05660642_04847"
                     /product="hypothetical protein"
                     /protein_id="WP_175479732.1"
                     /transl_table=11
                     /translation="MRILFVCTGNVCRSPVAERLATAWTREKLLHSPEADIVQIDSAGM
                     GATSGQPIDRHSAAALVDLGGDPAASCHASSRRR"
     gene            22428..22766
                     /locus_tag="BLS21_RS23855"
                     /old_locus_tag="SAMN05660642_04848"
     CDS             22428..22766
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="BLS21_RS23855"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="SAMN05660642_04848"
                     /product="hypothetical protein"
                     /protein_id="WP_091224321.1"
                     /transl_table=11
                     /translation="MTRDQRRTVLEASPRGLRRTFTLTEAADLVQRADLTGLSLLPLTA
                     RARELGRRLDAARADGPTADSDDIADPIGQHAAVHQEVAGLVAAALRPLADVLSTSIRV
                     QLPAPVAA"
     gene            complement(22870..23592)
                     /locus_tag="BLS21_RS23860"
                     /old_locus_tag="SAMN05660642_04849"
     CDS             complement(22870..23592)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF025053.4"
                     /locus_tag="BLS21_RS23860"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05660642_04849"
                     /product="protein phosphatase 2C domain-containing protein"
                     /protein_id="WP_175479733.1"
                     /transl_table=11
                     /translation="MPPVELTWGAATAVGQREDNQDRHLAAPPVFAVADGMGGHVGGAA
                     AAEAVVEALRSLTGSETTTVEAIRLALQRADGEIRAFQGPDKAGAGTTVAGVALVDEGA
                     GPQWAVFHVGDSRVYRWHGGQLELVTRDHSVVQELIDAGYISDQSAATHPQRHIITRAL
                     GVGPRPEADVVLLPVVPGERLLACSDGLTGELTDDRIAAIMSLDGAPEEAATSLVDNAD
                     TNGARDNATVVVVYATGP"
     gene            23747..24919
                     /locus_tag="BLS21_RS23865"
                     /old_locus_tag="SAMN05660642_04850"
     CDS             23747..24919
                     /GO_function="GO:0004553 - hydrolase activity, hydrolyzing
                     O-glycosyl compounds [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013126.4"
                     /locus_tag="BLS21_RS23865"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05660642_04850"
                     /product="glycoside hydrolase family 3 N-terminal
                     domain-containing protein"
                     /protein_id="WP_175479734.1"
                     /transl_table=11
                     /translation="MRSSRLGAVVGALICLLTTACAAPTAGPGTAPGTSGSAPPPTPSP
                     ETDPVDAALADLDRREQVAQLIVVGVALTDLSPADAFAAGGLGGVFLQGRSSIPADELA
                     TETARWAEAAPGPRPWIGVDQEGGAVQTLSGPGFADLPSAARQGRMPAEELAGLADDMG
                     ASLSSAGINLNLAPVVDVVPEGTEDANAPIGAWDRQYGSTADAVSTAAGTVADGLAAHG
                     VTPTLKHFPGLGRVQENPDKSRDATDDVTTGDDDQVAAFGTLAGSDAEPFVMMSSATYT
                     RIDPSTPALFSPVVVTDLLREQLGFDGVVISDDIGAAQAVQDLPADERVIRFLEAGGTL
                     MLTMDAGLVTEMIDAIVARAESDPAFSATVDAAVRTALTAKADAGLLPES"
     gene            complement(24947..25135)
                     /locus_tag="BLS21_RS23870"
                     /old_locus_tag="SAMN05660642_04851"
     CDS             complement(24947..25135)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="BLS21_RS23870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="SAMN05660642_04851"
                     /product="hypothetical protein"
                     /protein_id="WP_091224325.1"
                     /transl_table=11
                     /translation="MLYLVLTLGIGLGLVFTAVFTAIAAVYLSDPRAGVAAARARAARR
                     RVWADPNEAARAVGSWG"
     misc_feature    complement(25337..25352)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: medium, score: 16.26"
                     /tool="antismash"
ORIGIN
        1 acccccacga cgggcaggcc ggtggtctcg ggcaggccca gggccaggtt ggcgcactgg
       61 atggccgcgc cgccggtgcc cttggtcagg ttgtccaccg ccgccaccac caccagccgc
      121 ccggcgtccg ggtccaccgc cagctgcagc gccacggtgt tcgcccccag cacctgcgcc
      181 gtggtcggcc actgcccctc gggcagcagg tgcacgaacg gctcgtcggc gtaggccttc
      241 tcgtacgccg cccgcgcggc cgcctcgtcg accccggcgg ccaggggcgc cgagcaggtg
      301 gccaggatgc cccggctcat cggcaccagc gtcggcgtga aactcaccgt gacgtcccgc
      361 cccgccgcct ggctgaggtt ctgcaccatc tccggggtgt gccggtgcac cccacccacc
      421 ccgtaggcgc tcaccgcgcc catcacctcg ctgcccagca ggtgcggctt cgcggacttg
      481 cccgcgccac tggtgccgct cgccgcgacc accaccacct ccggctcgac caggcccgcc
      541 gccagcgccg gcgccagcgc cagggtgacc gacgtcggat agcagccggg aacggcgatg
      601 cgcttggcgc cggccagctt ccggcgctgg cccgccagct cgggcagccc gtagggccag
      661 gtgccggcgt gctcgccgcc gtaccagcgc gcccaggccg ccgggtcgcc cagccggtgg
      721 tcggcgccgc agtcgatcac cagcgtgtcc tcgggcagcc gcgcggcgac cgccgcggac
      781 tccccgtgcg gcagcgccag caccaccacg tcgtacccgg ccaggtcctc cgcgccgctg
      841 ggccgcacct ccaggtcggc gaacggcagc aggtgcggct gcagctctcc cagccgccgc
      901 ccggcactcg agttggcgtg caccccggcc agcgccaggt tcgggtgccc ggccagcagc
      961 cggcacacct cacccccggc gtacccggtg gcgccggtga ccccgaccgt ccacgtccgc
     1021 actccgctca cgctgagtga cagtacctgg gaaggcggac cctgcgccgt cacgcgaaca
     1081 ggtgatccca ctcaccggct gctgcggcgg aggcgggcga caacccctgc ttcgtcgacc
     1141 atctgcgctg ttcaacgtct cgccaggccg accgtgcgca cccgactcgg cgccgtgcga
     1201 ccggacagac gcgttcagtc ccgacgacgc gcccatcacg ctgagtgatg cctcgatctc
     1261 tgccagccgt cggagccggg gcccccctcg tcaccactgg gagggacccg ccccggggag
     1321 cgaccgctcc ccgccgaccg cgccgggccg gcgcggtcag gacagcgcgc cgacctcgcg
     1381 cagcacctcg aggacctcgg gcaggtcggc gaacgcctcc cggacgtcgt ccggggtggc
     1441 gatggagtgg gcgttcaccg ccacgtagtc ggccagggcg gcgtcgaagg cctcctcgcc
     1501 gacctgctgc cgggcctcga ccagggcggc gccgccgagg gtgtagacgg tgtcgtagta
     1561 ggcgctgttg ggccgccgga actccgccgc ccagtacgcc atggagccgc ccaccggcgg
     1621 ggagtcctcc gcggcgaggt gggcgaaggg ctgctcgtcg ccgtcggcca ccgtctgggc
     1681 gaacgtcgcg aacgactcgt ccagccacgg gtgctcgccc tggtcgttgc ccaccaggcc
     1741 gtagaaccac atgtgcgcga gctcgtgcgt caccagaccc cgccggtcgt ccgggtccac
     1801 gtcgccgaac tggatggccc cggggaactc gatgccgctc gtctgggcag acagcaccac
     1861 cacccacagg tcgtcgtagg ggaagggccc cagcaggtcg acgagctcgc cgttggactc
     1921 ctcgacctgg tccagccagg cctccgtgtc ggcctcgccc acccgctggt ccagccccac
     1981 gcggacgcgg acgccgtcga tcgtccgctc ggccacgtcc agctccccca ccgcgacggc
     2041 cacgtcccgc accgcggggg cggtgaagcg gtggacggtc gtcccgtcct gctggtcctc
     2101 cgcgccgtcc gccgccccgg tgccgaggac ctcgtagccg gacggcgcga cgacctccat
     2161 cgagtccagc aggaagtcct cgctcacggc ggtctcaccg atgaccggga cggcgggacc
     2221 gcgctcccag ccgcggccgc gctcccacgc caggaggggg aacgccgtgg cgaaccaggc
     2281 gacctccgcg tcggaggagg tcccgacccg ctcgttgacc tcctccccga ggaccaggtc
     2341 gaacgtcagc tcggcggtga cggtctgccc cgccgacacg cagtcggcca gcgggacctc
     2401 gaccagggtg ccggccggcg cgccctccgg tgcgccggcg gcgatgacga ggaagtcggc
     2461 gtcccgtccg tcgacccgca cgtccgacac cgtcaacgag ctccccgcac gcgaggtggc
     2521 cggcttgttc ggccaggacc ggaagaccag ttcacaggtg tccaggtccg gggtgaactc
     2581 gacgacctcg cgcccggcca ccgtcgcgag gtcgggcgcg acctcgaagc gcaggtcgac
     2641 cacgggccgg tcgggccacg gctcggcgtc gtcggccccc gggtcggcgt cacccagccc
     2701 cgccgaggtg cagccgctga ggaccagcgc cgaacacgcc agggcaaccg tggaccaccg
     2761 tcgacctgcg cgcatccccg tcctcgaggc ctgggcgacc gggcggtccc ggccggcact
     2821 cccattctga cgtgcaccca cccgcctgcg ttccgctcgc gacgacgagt gagccatctg
     2881 tcatcggcag gcggaccggt gtccctgaga cgggtgggac agatgagacg accgttactg
     2941 gttgttatct agcggatgcg cagcgcatgt gtcagcctcc ttcagtcact acgcaatcac
     3001 tgtccgtcgc caccggcgag cggatgtccg gaggaccact cgtgcgcagt tccctctcta
     3061 cggccggccg tcgcgccagc gtcctcgcgg ccgcggctct cgtctccctg gccaccgccg
     3121 cgtgcggccc cgccgacctc cagggcggcg ctgccggcac gaccggccag accgacgtga
     3181 gcagccaggc ggccatcgac cagccgctct cgctcggcga cgcccccacc gctccgagca
     3241 gcgccgtccc gacccccgcg gcaccggccc ccacgactcc cgcccagccg cagacgcagg
     3301 cccccgtcgc cggggccacc ggctcggagg tcgagggcac ggacgagtcc gcagcggcag
     3361 ccgtcccgac cgaggtcgtc cccggcgccc cgcaggcggc agccaccgca gaccagggac
     3421 gccggaagcg cgactcctcg tcgggccggt cgacgagcgc ctccgcccct gcccccgccg
     3481 ccgctcctgc tcccgtcgcc gcggctgccg cacccgccgc tgccggtgcc tccaccggcg
     3541 ggtcgggtgg gacgttcacc gaccaggcgc gccggtcctt caccgcgggc aacggtcaga
     3601 ccggcaacta cctgctctac gccgccggca tcgaccccgc gaagccggtc gggctggtcg
     3661 tctacgtcga cggcaccggc gagtacggcg tggacaaccc gacctcgtcc tacgcgctcg
     3721 gcggctcgtc ggggctggtg gccaccagca gggcgcgcaa catgatgacc ctcgccgtgg
     3781 agagcccgaa ccagtcctgc gagtgctggc acaccggcga caccagcggc tacgcggact
     3841 tcctcgccgg gctcatcgag aaccagctga gcaagtaccc cgtcagcgag gtgtggctga
     3901 gcggcttctc ctccggcgcg caggagatca cccgcttcct cgtgccgcga cacccggagc
     3961 tgatgcgcct cggtggcggc tgggtggtgt tcggcggcgg tggcccgccg gctgacggcg
     4021 ggtccgccgt gaccgcggcc cgcatggccg gtgtccgcgg ccactggttc accggtaccg
     4081 ccgacacgtc cgtcccgctg accgcctcct ggggtgcgca ggccggggag cgcttctacg
     4141 ccggccgcgg cgtcgtcacg tcgagcgagt acccggccgg cgtcggccat gccctcgacg
     4201 gccggctggg ccgcacggtc gggcagctga tcgacgcctc gtgacgacca cggtgggcgc
     4261 tccccgcggg gagcgcccac cgtggcgtcc gggctcagcc gaggcggtcc gcccgtcggc
     4321 cggcggtcat cacccggtcg accaggtcct gggtgaggtc ggcctggagg tcgtcgggca
     4381 ccgggagccc gctgtcggtg taccagtcgg gcgaggcctc ggggtgcggc cccacgacgc
     4441 ccaccgcgcc tcggccgaag ggcgcgacga ccgccgcggg cagcccgttg tcgtaggtgg
     4501 ccagcacctc cgccggtccc cgggccgggt ccaggtcgaa ccacgcaccg tcctggaagt
     4561 agacctggcg acggcgtccc gcccaggtca gggtgacgat gctgtcgccg tcgtggtccg
     4621 gccgggcacc gggcgaggag atgaaccggt cggtgtcccc gggcaacagg ccgaagccgg
     4681 gggtctcgcc ggcgaggtag ccgcccaggc agaacccgag gtaccccccg ccggacccga
     4741 cgaactgccg gatggcctcg cgggagcgcc tcatcttccg gtacgcccgt cgcaggccac
     4801 ccccgccggg ctgggcgtag agccgggcgc cggcgagcac gtccggctcc agcgggaggt
     4861 cctcgcgcgg cccgacgaag cggacgtcga ggtcccacct gctccggcgc agcgcggccg
     4921 ccaccgcctc cgggcacccg ggggtcgacg ccggaccgcg gtacacgagc gccaggctcg
     4981 aggcgtggga gcccgggacc gggacgtcag ggcgcacgta cccggccgtc gtcgtcgagg
     5041 accagcacct cccgccgcgg ttccgtcatc gaccgcaccc tgcggcgcac cgcaccggtc
     5101 gcctgggcca cgacctcctc cagcgggccg cgcgcgtggt agcggcccca caccagcgcg
     5161 aacgccagga cgagcactgt ctggatgagc agccccgtcc caccgtccgg catcaccgac
     5221 cagctcagca gcagcaggtg cagcgagtac agcgtcaggg tcatgctccc cgctgccgcc
     5281 agcggccgga ggagcgcggt ggtggcgcgg ccgacgagga tgcagacgcc gaggacgacc
     5341 agaccgagcc cgatggtgaa ggccaggtcc agaggcgtgg tggagtgcgg ggccagggtc
     5401 gccagccacc agccggtgtc cgtcggcgtc gtcccggtcc acccgacccc catgacctcg
     5461 gccagctccc cggaggtcat ggaccggctc gcgaccgcct cgagctcggc gcggccgccg
     5521 aggacgtcga gcaggaacca cgagatcgtc tgagccgcca cggccagccc ggcgccggtc
     5581 agcgtgatca gcacgacggt gcgccgcgag gtcagcagcg cgcgcccgac cgccatgccg
     5641 acgcagaggt aggccatcca ggacagggcc gggtacacgc cggtcagcgc gagctcccgc
     5701 agcacctggc ccggggcgct gaccaggtcg ccgaacgcca ggttcggcac cgtgtcccgc
     5761 acctcggtac cggaccgcag ccagtggctg aggaccggca tgacgacggt gatcgtcgcg
     5821 gccagggcga tgagcgcgcg gctggacagg gtgagcagcg ggatcgcgaa gacgaacagc
     5881 agcgcgtagt acggcaggat caccgaggcg aagtcggcgg gcaccacggc acccaggagc
     5941 agcccgacgc cgccgatgat gagcgcccgg accagcagcg cggctgcgta cccgggccag
     6001 gtccgcgcgg tcggccgctg ccggcgcccc gtggcgaacg cgacgccgac gccggccagc
     6061 agcgcgaaca gcgccgccga cttgcccgcc gccagcgtcc acgccagcga cacctccccg
     6121 tcgtcgtcga cggcggtgat gttgtggacg gccatcatgc cgaacagcgc gatcccgcgg
     6181 gcggcgtcga tgccgaccag gcgggcgctc ggccgcaggc ccggcgcggt gctcgacggg
     6241 gtgccggaga cgtcgccgga cggagccggc tcgcaggcgt ggggcagcga cgactgcctg
     6301 ctggcggtca tcgccgggcc cccgtcgccc cggccgacgc ccggcgccgg tcgcgcgccg
     6361 gcgccgccgt cggagcccgc ccgaccttct gggccgggat gccgcaccag gtggtctccc
     6421 tcggcagcac ctcgcccttc atcgccagcg acatcgcgga cagggtggcg tcctcctcca
     6481 cgaccgagcc gtagaggacg acggccttgt caccgatcgt cgcgcggtcc cgcaggatga
     6541 cgtggtccat cttcatgacg cggtcctcga agaggtgggt ctgcagcgac gcgttcgcgc
     6601 ccaccgagac gtcgtccccg atggtcacga ggtcgaactc ggtgaggtag gtcgtgtcga
     6661 ccagcgtccg ccggccgacc cgggagccga acaaccgcag cgccgggccg agcaggggcg
     6721 tgccggtgag gaaggtgagc agggccggca ccgccgccgc ctcgtagatg ccggtcacga
     6781 actccgtccg gcggacgaag ccgctccaca gcggtcgcac gcgcggccgg tagcggccga
     6841 cgacggccca cttgagcgcg gccaccagga ccacgaccag gacgctggag gtcagggcga
     6901 ccagcggcgc gagcagcacg gtggccaccg tgttccagga gagcgccagc gcggagagcc
     6961 cgtacagggt cacgaacgtc gcgacggcca gcagggagct cggcagcacg atccggagag
     7021 cctcgatcgc gtagcgggca cggacctgcc gccgcgacgg ggcgtaggtg tcggcctcgg
     7081 tgaactcctc gaacacctca cggcggggga ggaagaacgg cggtgagccg agccacgagg
     7141 tgccggcctc ggtcccggcg gtcggcggga ccgagcggac gccgatgagc gacccgtcgc
     7201 ccaggtgcga gcccgacggg acgaaggcgg cgttcccgac gaaggcacgg gagccgatct
     7261 cggtccgccg gaaggcgacg tggccgttgg cgtaggtggc gctgcccacg ctggccatgt
     7321 ccgccacgaa gctgccctcg cccaccgtga gcaggtccgg gtcgatgttg gcgatggtgg
     7381 acacctcggc gcccttgccc accctggtcc cgagcgcccg cagccacatc ggcgtgtaga
     7441 gcgtcgagta catggtgttg ttgaacagca ggctctgctc gagcagcttg tcccccagcc
     7501 acttctccag gcccagctgc gaccgcaggt ggtgcacgcc ctccggggtc gccggcagga
     7561 ccaggcgccg ggcacccagg atgagtgcgc acgaggccgc cacgaacagc gggccggaca
     7621 gcgccgtggc caggaggccg gccgccgtcc cgaagctgag caggacccac cagacgaccg
     7681 ccaccaccgg cagcaggatc atgaagggca gcagctcgag cagcaggaca ccaccggcga
     7741 agccggccag gaggcggctg gaccaggtgc gcggcgcctc gtcacaggcc gccatgagct
     7801 cgacgaccgg gtccatggag ccgggcgccg gccgggccgg ggacccggcc caggtctcgc
     7861 ctgcggggac gatccggcgg gacggcagca gcgactggtc gctgaggatg gcgttctcgc
     7921 cgacctccga gtcgcactcc agcacgctct cggacccgac gaccgcgccg gcaccgacgg
     7981 tgaccgggcc gatggtcagg atgccctcgg cgatgcggtg ggcgtgcagc tgcgtgccgt
     8041 agccgatcgt cgcgccgcgg cccacccgca gcatcgacgg cagcgagacg ttcgccgtcc
     8101 cgatgtgggc ctcgtcgtcg atctgcgcac cggccagccg caggtacgtc accgcccacg
     8161 gggaaccgct gaggacggtg agcggggaga tcgacatcag cttctgcacg gtccacaccc
     8221 gcaggtgcat gccaccccag agcgggtggt caccggcgcg cagcccccgg gagagcagcc
     8281 gcgcgccgac gaccgggagg acccagcggg ccagcaggta gaccgccggc agcgcgaccg
     8341 ccagctggag gaccagggcg agcgagggct ggccgtcgtt gagcccgtac aggacgccga
     8401 cgggcagcag gaacagcagg atgatcgcgt agaggatcga gacctgcgcc gtcccgaagc
     8461 cgaggacccg ctcccgcgac ggcggttccg gccggggctc gcgcggctcg agcgtcaccg
     8521 gctcgtccga cgggccggcg gtgccgtcct cgaggaacgt cgcgaggtcc cggacggtgg
     8581 ggtgcttgta gaagtccagg atggacagcc ccgagccgag gtcgctctcc cgcatcgcgg
     8641 acacgacgtt cgccgcgacg agcgagtgcc cgcccagcgc ctcgaagaag ttcgcctcca
     8701 ccgagaccgc gccggccggc aggttgagca tctcctccca caggccggcg atccaggcct
     8761 ccgcgggggt cgccggcggc tcgtgctcgc ggtcggtgcg gatcagccgg ggacgggtgg
     8821 gcgcgggcag ccggccgcgg tcggccttgc cgctgggcag catcgggatc gaggtgaccg
     8881 cgtcgaggta cgacgggacc atgtagggcg gcatctgggc caccagctgc tcgtgcagct
     8941 cggggatgac ggcgtcggcc gccccggcgt cccgcaggat gacgtagccc gcgaggtccc
     9001 cgccggtgtc cggcgaggcg agcagggtga cgacggcgcc ggtcacctgg gggtgctcga
     9061 ggaggacgct ctcgatctcc tgcaggtcca cgcggtggcc ccggaccttg acctcgctgt
     9121 ccgcgcggcc caggtactcc agctcgccgt cgggcaggaa gcggcccagg tcgccggtgc
     9181 ggtagatgcg ctcgccgggg atgccgcggg ggtcggggat gaagcggtcg gcggtcaggt
     9241 cggggcggtt cacgtagccg cgcgccacgc cgggaccgcc gacgcagatc tcgccgacct
     9301 gccccgcggg gaccggcttg cggtcgtcgt cgagcagggt gacccggtag gtcggcaggg
     9361 ggcggccgat ggtcaccggc ttgcccggcc gcagctcggc catcgtgcag gtcacggtgg
     9421 tctcggtggg cccgtaggtg ttcaggatcc ggcggcccgg tccccagcgg tcgaccagct
     9481 cgcgggggca ggcctcgccg ccgacgttga ccgtgcggat cagcggcagg gtgcggtcga
     9541 gggtggccag cacggtgggg acgcagtaga tcatcgtgat ctcgttgtcc tcgaggaagt
     9601 cggccagccc cgacccgacc cggcggccgt cggtggggcc ggcgacgagc gtcgccccga
     9661 cggcccaggt gggccagatc tcctcgatcg agaagtcgaa cgcgatcgtc atgccctggt
     9721 agacgcggtc ggtggactcg accccgtaca gggacggcac gatgccgacg aagttgcaga
     9781 tgctcgactg gttgacctcg acgcccttgg ggcggccgct cgagcccgac gtgtagatga
     9841 tgtagcagac cgggtcgccg tcggactcga tgcccggccg ggagctcgac tggaccgcga
     9901 gctcgggccc cagctcgtcg aggtagaggc tctcgcaggg cagcgcgacg caggacgccg
     9961 cgaacgacgt gtgcgtcacc agcatgctca gcgaggagtc ctcggcgatg tactgcagcc
    10021 ggtcggccgg cgcctcgggg tcgatcggga cgaacgtcgc ctcggtcttc gtgacggcca
    10081 gcagggcgac gtaggtgctc accgagcggt gcaggaggat ccccacgcgg acgccggcac
    10141 gcgcaccccg ggccatcagc aggttcgcca gccggttcgc gcgctggtcc aggtcggcgt
    10201 aggagacgcg ctcgccctcg cactcgagcg cggtggccga cggccgctgg tcgcaggtgt
    10261 gctcgaagaa ccggctcaac cgggtgacca gcgagcgctg tccggagatc tcggccacga
    10321 agttgtcgtg cagccggtac gacgtggcgg tgttgtcccg catgtcgtag cccggagcgg
    10381 tggtcggggc ctgcggctcg acatctcccg cgaatgtcga gaagaagtcc cagtcatcgc
    10441 tgtgcgtcgt catatattca ctctctgcag cccttcgatg aacgaactcc tcgaggttag
    10501 gtgggcgttt cggagaggcg caaagtccgg ccgcaagggt cgaaaggctc gtgtggcaac
    10561 cccttgacct ggcggaacag gcgtttccat cacggaggat gaccgatcta tctcttaccg
    10621 tgatggcccc gcgccgaaat gcgtcggtgg cttacattct gctgttgagc attcacgcac
    10681 agcagatcgg cgacgtctcg ccggctcgtc gacacgccca gagcggtgac ggaggtggat
    10741 cgtagaatgg gagaagagtc acccgatcgt gggcccctcg tcctcctcgc ccgccccgag
    10801 gacgtgctcc gcgtcggggg cgaacacctg ctgacgcccc gcgagcggcg acgcgccggc
    10861 gcactgcgcc accgggccga ccgcgacgcc cacgtcgcgg cgcacctgct cgtccggcac
    10921 tgcgccgcgg cgctgaccgg tcggccggtc gaggcgctcg agctggtgca ggagtgtgcc
    10981 gagtgcggct cgaccgagca cggcagaccc tcgatcgccg gtctccccga gctgcacgtc
    11041 agcctggcgc acacccgcgg cgccgtggcg gcgggcgcgg accgacggcc gatcggcgtc
    11101 gacgtcgagg gagcgcggac gagggacctc gaccccgccg tcctgacctc caccctgacc
    11161 gccgccgaga cggcccgggt ccggtcggcg agcgacccgc cggccgcctt cctccgccac
    11221 tgggtgcgca aggagtgcct ggtgaaactg ggcgtggtca ccctcgacga gctgtccggc
    11281 gtggaactcg accccacgac ggagcaggac gtcgaggggg gccgcacgcg cagccggttc
    11341 gggcccctgc acctgctgga ctggttcgac ccgaccctgg acgtcgctgt cgcggcggcc
    11401 gcccacgggc ccccggtggt cggctccgcc cgcacctggg cgccccgccg cccgacgtga
    11461 cggcggccat gccagcagtg gggggaccgt ggtcgcggac ggccggcacg ggcgccgacg
    11521 agggtggacg acggtcacgg cctgcttccc cgatccgctg gagtcctccc cccgatgggg
    11581 catcggaccc ccgtgatctg cgcatccgtg cgtagagtcc gcctccggct gagcccgtcc
    11641 ccgtcctccc ggaggttccc ttgcgcaggc ctgtgaccgt cctcggcgcc ctggcactcg
    11701 tgttggcggg tgccgggacg gcgtccgccg agcccccgct cgaggtgacc gagcagatca
    11761 ccgacgcggc cgggctcctc ggcaccgggg cgccggcggc cgagcaggcc gtggcggacc
    11821 tggcggccga ggacgacctg gacctgtacg ccgtcctcgt gccgtcgttc gacggcgccg
    11881 accccgggga gtgggcgcag gacaccgcac ggcagtccgg actggacgag accgacgtgc
    11941 tgctcgccgt ggccgcgggg gagtcggcct acgagtacgg gtactgggtc gccgacgact
    12001 tcccgctgtc cgaggtcgac ctcgaccgcg cggtgaccgc cgaggtggag ccccggctcg
    12061 cggcgggcga ccggtccggc gcggtggtgg ccctggcctc ccagctccag gacctggcgg
    12121 cgaccgagga ggaggcggcg cagcaggagg ccccgtggtc cgcttccacg attatcctca
    12181 tcatcggcgg cgtcgcggtc gtcctcctcg ccgcccacct gctctcccgt cggaggtcct
    12241 cgaccaccag gtcctgatgt ccgtgaccac ggctgtcggc gcgtgctgac ttcctgtggt
    12301 caggggcaca caggagctgt acaggtcgat cacggggaga ccgcaggcgt cccgtccacg
    12361 ctgtgctcca tgacctcccc gacggtgatc cccagtgagt cgacgcccgt caccgcacca
    12421 gccccgcggt gttcatcacc cggcgtcgct gaccgacccg ccgtcgtccc cacccaccct
    12481 gccggggagc ccgcgggaag cgctggggcc atgagcctcg ccgcgccgca cgacccggcg
    12541 ttctgcgcgg ggacggggtg ctcccgacac cacccgagca accaccacat gcgggcctgg
    12601 ccgaaggtct ggcgcgagta ctacggctac tccgaccgga tgtgctcgca cggcgtcgga
    12661 caccccgacc cggacgacgt ggtccacctc caggcgctcg gtgaggtccg caccgagcac
    12721 gcgtgcgacg ggtgctgcat cgcgcccctc agcaccagcg cctgacggcc gcggacgtca
    12781 gccggagacg cggtcgcgca ccgcaccggg gacggcgagg ggctcggcgt ccgcctcgcg
    12841 gcggagcacc caggaggcgg gcagcaccag gcgcggcgcc acaccgacca ggacggcgac
    12901 cagcacggcg acgccggcca gcgcctcccc ggactcctcc aggtaggtgg cggtcaccgc
    12961 ccactgcccg gccgccacgg cggagacccc ggagaggccg accgacgctc ccgcgtagcc
    13021 ggccaggcag gtgagcaccc ggcggcggtc gcggcgctcg tcccggctga ccacggccag
    13081 gacggcgagc acggtggcga cgagcgcgac gctcacgacg acggcgccgg tctcaccgat
    13141 ggcggacgag agcgccctca tggcctcgac gtgcacggtg ccgccggcct tgacgacggc
    13201 gatgccgccg cagaccagcc cgacggccag ccaccaggcg cggcggtggg gtacgcgggc
    13261 ggctccggcg accgcggcca cggcggcgac cgcgaacagc gcggcgacga aggtgcgggg
    13321 cgcggagaac ggggcgtcca tggacagcgc gcgggccacc ggaccggtgg cgccggtcag
    13381 ccgaccgacg tagccgacgg tctcgagcag caccgcggtc gcggccaggc cgatcccgac
    13441 cggcggcagc gggacgcggc ggcgcggcgt ccgcagccgc aggtcggcca gcggctcggg
    13501 cgtggtcagc gggtcgacgg agcgggcgtc cgcgatccgg atgccgcgac cgacgacgac
    13561 ggccagcgcg aaggccagca gcagccaggc gaccagtccg ccgacgaccc acatccacac
    13621 gtcccggtca tcggcaggtg aggaaccgat cggaacccct cggccggcgg gccacccgaa
    13681 cgggtgggtc agcggcgcgc gctcacgccg ggctggaacg cggcggggag gtcggccctg
    13741 gtgaacagcc gctccgcgcg ggcccgggcg tcggccgggc ggatgccgcg gcccaggacg
    13801 acggcggccc cgagggccac cagggcacac accaccagca cgccgatcac caacgcctcc
    13861 gtgcgtccgg catcggctgt ctccatgccc acggtgaccc tgcgtcaaaa caccatcacc
    13921 aagggtcact cggatcgccc tgcgggatgc acctgccccg cccggcgcgg cgactgagag
    13981 cgcggtggct ccagccgtca ccgcaccacg cccggtcggc tcacgtcgct gtatcagcgg
    14041 ggtgcgagcg tgcctctccc cgccaggacg gtgggaactc ctgcgatggg ggaaagcgtg
    14101 gaactgcacg gagctgtcaa cggatcgccg cggcagctga ggagcgggaa cggagcatgg
    14161 cctctgctcg aggggggcga ccgggaaccc ccctgcgatc agggtgcccc ctgcctcgac
    14221 gacctcatcc aggcgcaccc ccacggcagg accaggggct ccagggagga cttcgcgagg
    14281 ctgctcacgc agtaccgggg aaccgaccac gagatcgtcg accactactt cgcgaagcac
    14341 atccacgccg gagcgctgca catgtgccga cgaactcggt tccacaggcg gaaggacttc
    14401 gagatccgca tgaggtaccc cggggacatc gtcgccgccg tgcagcccga gttcgaggcc
    14461 gcgctctggc gggcgcgcgc gatggagcag cagaccgcgc tgctcgtggc ggggcgcccc
    14521 cgccgggtgc tcctcgagat gctcttctcg gtgatcgtgt acctgctcgg ggtcctggac
    14581 tccgtcgagt gcctcgcagc tgcagggcga ggagcgcgga agaccaggga gtgcagtcgg
    14641 gtgcaccgca tcgagaaggc cctggagatc gcgcagagcg aactgacgcg gctgcaggag
    14701 ttcgccgacc aagcggcggt cagggccgcc ctcaagcact acgtgcaggg tctgttcatc
    14761 ggcgggggtg ctgtggtggc gtcagcatgg acggccagcc aggtgcacat gttcgagcag
    14821 gcgccgacgc tggacctggt gcgcgcgatc gcagccggtg gactgggtgc catcatcagc
    14881 gtgctgatcc ggatcagccg tggccagcgg ctcgacgtgg acaccacgca ggaaccgttc
    14941 ttgacctgct tggcgggcag ctcccgcacc gtcatcggcg gcgcgctggg ggtggcgctg
    15001 tacgtgctgc tgaaggcgga gttcatcccg ctcgagatcc ccgcggcgtc cgacgccgcg
    15061 gcgccctact tcttcacagc catcgcgttc ctggccggct tcagcgagcg ttgggcccag
    15121 gacaccatcg tccggagcac gccgctggcg acatcggcga gtggttctcc catcccgtcg
    15181 acgagcacac cgtgcgcctc tgcgccgacc gagtcagcag ccggtggcgg aacgggagcg
    15241 ggcctcgtgc agacgacgag cctgccggtg atcgcgcccc ccacacccga cgggaccgac
    15301 ctggctcggc gacctcccga ctgatcgagc gctgcgcgga tggagggtgc cgctcacccg
    15361 gatccggtcg cgctgtcggg gcacagcacg cagaactcgt tgccgtcggg atcggccagc
    15421 accacccagc cgacctcgcc ctggccgatg tcgatccgag tcgccccgag ggagacgagg
    15481 cggtcgacct ccgcctgctg atcaccggtg gcaggtggcg cgaggtcgag gtgcagccgg
    15541 ttcttccccg tcttcggcat cagcggcgga ccgccccagg tgatcttcgg accgccgtgc
    15601 ggcgagcgga tcgcggtctc ctggtcctgg tcccagacca gcggccagcc cagcgcgtcg
    15661 cgccagaagt acccgacctc ctgcgaaccg tcgcacgcga gcgctccgac gaacccgcag
    15721 tcagcgagga agcggttgcc cggctcgatg acgcagaact cgttgccctc ggggtcggcg
    15781 agcaccacat ggccctcctc cgggcgctga ccgacgtcga tgtgccgggc accgagcccg
    15841 agcgccctcg ccaccgtctg ctgctggtcc tcgcgcgacg tgctggtcag atcgaggtgc
    15901 atccggttct ggccggcctt ctgctcctgg gtcggcagga accggatccg gaacccggtg
    15961 tcgtcgctcg gcaggagggc gaggccgacg tgggactcgt cggccatctc ccagcccagg
    16021 aggccggccc agaatcgcgc gagaccgagc gggtcgtccg cgtcgaagct gagcgcgacg
    16081 aggtggcaag gcatcccgct cggcaactcc gatctgctga ctcgcagccg caggcagggc
    16141 acgtcctccg cgcccatgag gggagcgacg ctagggcgct cggagactgc ggtgcaaacg
    16201 agttcgcctc ctccgcggac gcccgtagtc gccggccgtc agccggcgcg gcggccgagg
    16261 gcgcggtagg tccagccggc ggcggtccac gcctcgcggt cgagggcgtt gcgtccgtcg
    16321 agcacccgct tctgcgcgac gacctcaccg aaggcgaccg ggtcgagctc gcggtactgc
    16381 cgccactcgg tgagcaccag gacggcgtcg gcgcgctcgg ctgcctcctc cggggtggct
    16441 gcgtagtcga gctggggcca ctgccggcgc gagttctcga tcgcggcggg gtcggtgacg
    16501 gtcacgaccg cgccctgcag ctgcagctgg gcggcgacgt tgagggccgg gctgtcgcgg
    16561 atgtcgtcgc tgtcgggctt gaaagcggcc ccgaggacgg cgatgtgctt gccgagcagc
    16621 gacccgtcgc agacctcgcg ggcgagctcg accatgcgga tgcggcgacg catgttgatg
    16681 ttgtcgacct cgcgcaggaa cgtcagcgcc tggtcggcac ccagctcccc ggcccgggcc
    16741 atgaacgccc ggatgtcctt gggcaggcag ccgccgccga agccgaggcc ggcgttgagg
    16801 aacttgcggc cgatccggtc gtcgaacccg atcgcgtccg cgagctgctt gacgtcggct
    16861 ccggtggcct cgcacagctc ggccatcgcg ttgatgaagc tgatcttcgt ggccaggaac
    16921 gagttggccg cggtcttcac catctccgcc gtggcgtagt cggtgacgac cttgggggtg
    16981 ccggtggcga cgatgggcgc gtagacctcg tcgagggtgg cgacgatgga ctcggcgtcc
    17041 ggaccgtcgg ggaccccgta gaccagccgg tcggggtgca gcgtgtcgcg gacggcgaag
    17101 ccctcgcgca ggaactccgg gttccaggcc agcagggagc cgggcacctt ctcgccgaac
    17161 atgcgggcga gctccgcggc cgtgccgacc gggacggtcg acttgcccac gaccagctcg
    17221 ccgggctcga gcacctgcag cagggactcc gcggccgcct ggacgaagcg caggtcggcg
    17281 gcgtactcgc cgtgcttctg cggggtcccg acgcagacga agtgcacctg cgcgccggcg
    17341 gcgtcgtgga cgtcggtgct gaagctcagc cggcccgacg cgagggagtg ctggagcagc
    17401 tcggcgaagt ccggctcgta gaacggggcg cggcccgcgc acagggcggc gaccttccgc
    17461 tggtcgacgt cgatgccgac cacctcgtgg cccagctcgg ccatcgacgc cgcgtggacg
    17521 gcgccgaggt acccgcagcc gatgaccgag atccgcatga ccgtcgtgcc ttccctctcg
    17581 agcccccctc aaccactcaa gaactgaagt gcaccacgac gggtggcacg gcgcccggcg
    17641 agcgcgtggt cagggagccg gacggacgac gccgcagcgg caggcgtaga ggctcgagcc
    17701 gctgatgggg tcgtcactga cccagcggaa agaggtgccc gtgggtgcgt ccgccggagg
    17761 acggcatcgt ccgcgtccgc ccacctgcgc tctactgcgc accgaggtag cgcacggacg
    17821 aggaggcacg cggagggtgg gtgtggacca ccgtggtggt ccgggtgctg ctcgccgtcc
    17881 ccgtcgccgt cctgctcggc cggatcatcc agcgcgccga cgatcgagag ctggggtcgc
    17941 tcgaccgccc ctcgcgcggg gacgacctcc cgtcgcatcc gcacgaggcg gggtcgttgc
    18001 gctgactgct cacccctgag ggtggctacg gcctgacctg cgccgttccc gtccgtaccg
    18061 tcggcgacat tgccgggtgg acgggggcca catgagcggt gcgaccggga cggcggcgcc
    18121 ggatcgccac acggacgagg gtgcggagcc ctcgtcacgg cgcagccgga cggtgcgccg
    18181 ggtgctgatc agcctcggtg tcctgggatc ggtcgtcgcc atggtcgtcg gcggggcgct
    18241 gtggttcctc accgaccgct acgccggcaa catggagcgg gtctccgacg ccttcgcgag
    18301 cctcgacgaa ggagcccgcc ccgcgccggc gacaccggcg cagcaggccg gcgaggagcc
    18361 cgtgaccttc ctgctcgtcg ggtcggacac ccgcgccacc gccgaggagg gcatcgccgc
    18421 cggcggccgc tccgacgcca tcatgatcgc ccggttctcg gccgaccggc agcacgcgca
    18481 actgatctcg gtcccccgcg actcgtgggt cgacgtcccc ggccacggca tggacaaggt
    18541 caacgcggcc tacgcctacg gcgggcctgc gctgctcatc cggaccgtcg agcagctcac
    18601 cgacgtccgg atcgaccact acgtcgccat cgacttcgag ggcctcatcc aggtcaccga
    18661 cgacctgggt ggggtggacg tcgtcgtcgc ggagaccacc agcaacgggc cgtacacctt
    18721 cccggccggg gtcaaccacc tggacggcga ccaggcccgc tggtacctcg ggcagcgcta
    18781 cggcctgccc ggcggcgact tcgaccgggt gcgccggcag cagcagtacc tgcaggcgat
    18841 gttcggcaag ctgttcagct ccgacacctt caccgacccg ggccggctgg acgccgcact
    18901 cctggcggtg accagcgcgg tcgcggtcga cgagcagctc ggcaacaccg agatcttgtc
    18961 actggcctac tcgctgcgtg gcctgacgcc ggacgacgtc gacttcttca ccgcgccggt
    19021 gctgggcacg ggcacggaag gcgcggcgag cgtcgtctac ctcgacggcg tcgcgggcga
    19081 gcgcatgtgg ggctacctgc agaccgactc gctgtcgcag aacgccgagg agttcagcac
    19141 ccaggcgctg cccgacgtcc cgcgctgagc cgggcgaccc tccggcggcc gggccgggca
    19201 cgccgtgttc tccaccgcgc cggcgggtat gccgagtgat gagacgacgg cgaggtcgga
    19261 ggtcaccatg acgactcaac ccagcgccgc gaacgtcccg cccgacaacg agacgagcag
    19321 cagctccccc gacggcggca tgccggtcgg cgccgccgac gcggaagcag acgcccgacg
    19381 cagcggagcg ggcgaccagg acgagcggcc cagcaacgtc ggcgaggggc tcctgctgga
    19441 cgtcgatccc ggccaggaga ccgacggcgg cgtcccggtg ggccgagccg acgcggaggc
    19501 cgaccggatg ggttcggccg agggcgacga ccgcacgtag gcagccccgt ccggaggatc
    19561 gcccgtccgc acccggcccc ggcagtagct ctctacgctc cacgcgcatg gcacgacacg
    19621 tgctgttcgt ggcactcgcc gggcacgggc acgtcactcc gacgctgccg ctggtggagg
    19681 agctggtacg gcgaggccat cacgtggcct acgccacggc cgccgacttc gccgaggtcg
    19741 tgaccggcgc cggtgcgcag tgggtgcagc tgccaccgat ggcgccgttc cgccccccgg
    19801 cgcaggtcgg cccggacctg atcgcctctt ggtttcggca ctacttcgcc gcgatgcgcg
    19861 cgacctatcc ggtgctccac gagtactgcc gcaccgctcg accggacgcg gtctcctacg
    19921 acgtgaccaa ctggccggcc cggctggtgg cccaccacct gggcatcccc gccgtgcggc
    19981 tgatccccaa cctggccgag aaccacgcgt actcgctcga cgacaggctc accgaggggc
    20041 tcgacccgga ccacccacag atgacggccc tggccgagga ctgtgtccgc ttctccaccg
    20101 agtacggagt cgacctcgac gtcgccggga cgatggacgt tcccgaagcg ctgaacctcg
    20161 tcttcatccc ccgcgagttc cagccggccg gcgactcgtt cgacgagcgc ttccacttct
    20221 tgggcccgtt gctcggtcgc cgtgagcagc gggagccctg gtcacccccg gacccgcacg
    20281 cccccgtgct gtacatctcg ctcggcacga tcttcaccga caaccccgcg ttctaccgca
    20341 cctgcatcga ggccttcggc gacggctcct gtcaggtggc gatgaccgtc ggggatctgg
    20401 acccggccgc gatcggaccc gtgccacccg gcatcgatgt ccggccgcgc tttccgcaac
    20461 ccgccgtgct gcgccacgcg cgggcgttca tctcgcacgc cgggatgaac tccacgatgg
    20521 aggccctcta ctacggagtc cccctcgtca ccctcccgca gatgcccgaa caagccgcca
    20581 atgccgaccg cgtcgtcgag ctgggtctcg gagaacgcct cgccacggac acgctgaccc
    20641 cggacgccct gcggcaagcc gtctcccggg tcaccacgga tgagcaggtc cgggccaacc
    20701 tcgagcgcat gcggcgggcc atccacgacg ccggtggagc ggagcgcggc gcggcactca
    20761 tcgaagacca tctggcctga gatcaccgag gcgaccatcg acctcagaga atccggcccc
    20821 cggccgacgt cggtgggttg tccctgagga cggctctcga tgtccctcgc ctcacgtcac
    20881 ggaccaccgg tgacggcccc gtgacgactt ggtgacggtg atgctgctcc cctgtcgact
    20941 tgcgcgcaga cgatgtgcgg accgcagttc cgacaggcga gggggctcac gtccatgccg
    21001 ccagggcgga agcgatatga cccagagagc cgcgctcggg cggtccagat gtacaagaag
    21061 cgactgaggg agaccgggga tcctgaggtt gcggttcgcc gtcaggtcag tgagcagctc
    21121 gggatcaacc agaccaccct gcgtcgctgg atccagcgtg aagcagcggt ctccggcgac
    21181 cctgccggcg ctgccgcccc cgcttcacgc ccggtgtggt ggagacgtcc ggtgacctgg
    21241 gtcgcggggg tcatcggtac ggccctgacg gccaccgcag tcaccgccgt gggcagccgc
    21301 ctcgaggagg tagtcaccaa ggccacggag acagggcctc ctgtctccgt ggaccaggtc
    21361 atggagttcc gcagcgacat gtacggcgat tcggtcgcgt tcgcccgagg tgcatcattt
    21421 acggacgccg acctggccga gctcaatcag atcgatcaag acttcggcgg aatggactcg
    21481 gtggagtggt tggagagccg gggtggagtt gcccccgata tcgtcctcat acagttggca
    21541 ctgtcaggaa acaggacggg gagcgtcagg atcacgaact tggaggtcca ccctgactgc
    21601 tcggcgccgc tcgatggact ctggttcgag gacccgcctg ctggagcgga cgactccatc
    21661 aggatgcact tcgatctgga tgactcgaat ccggtggcga aggtcgcctc gatggacggc
    21721 tcaccaacag gggagccgga ggactacttc ccagcgcgga ccatctcgct caagcaggga
    21781 gagcagcaag tcatcatcgt ctcagcgagt accgaagaga agtattgttc cttcttcctc
    21841 gacatgacgg tcctcgaagg ggacgagacc agtacacaca ggatcacgat gccggctggg
    21901 tcgcctttcg aggtcacagc atccttgccg ttggaccagt atgaagaggt ctacctcggt
    21961 ggcgtcgtct gctacccgtg ggtgaaggcg ggcaacgcgt tcttcaacgg ggactgggag
    22021 caccagtgca gctagggcgc gtcccccgac agcgggctgc tcggggcgac tgcgtcgggc
    22081 gttgcgcatg cacctccccg tcgcgggtga ggtcctcagt gaatgctcct gtcgcgactg
    22141 catgcgaccc agcgtcgagc cgtgcgcatc ctcttcgtct gcaccgggaa cgtgtgccgc
    22201 tcgccggtcg ccgagcggct cgccacggca tggacacggg agaagctcct gcacagtccc
    22261 gaggccgaca tcgtccagat cgacagcgca ggcatgggcg cgacctctgg acagccgatc
    22321 gaccggcact ccgccgccgc gctcgtcgac ctgggcgggg acccggcggc ttcctgtcac
    22381 gcgagttccc gccggagata gcccaggacg ccgacctggc gctcaccatg acccgcgacc
    22441 aacgccgcac cgtgctcgag gccagtcctc ggggtctgcg tcgcacgttc acgctgaccg
    22501 aggccgcgga cctggtgcag cgagcggacc tgaccggcct gtccctgctc ccgctcaccg
    22561 cacgcgcccg cgaactgggc cgccgtctgg acgccgcccg cgccgacggg ccgaccgcgg
    22621 acagcgacga catcgccgac ccgatcggac agcacgccgc ggtgcaccag gaggtcgcgg
    22681 gcctggtcgc cgcagcgctc cgcccgctgg ccgacgtcct gtccaccagt atccgagtgc
    22741 aactgcccgc tcccgtcgcc gcctgagcgg cacgggctcc gggacgtccg tccggccgcg
    22801 aggtgacgac aactcacgcg gattgagggt ctgcgtcggg tcaccgaccg aggccaggag
    22861 gatccgtgat cacggccctg ttgcgtagac cacgacaacg gtggcgttgt cgcgcgctcc
    22921 gttcgtgtcg gcgttgtcga cgagcgacgt cgcggcttct tccggtgcgc cgtcgagtga
    22981 catgatcgct gcgatccggt cgtcggtcag ctcaccggtc aacccgtcgg agcaggcgag
    23041 gaggcgctca cccggcacga cgggtagcag gacgacgtcg gcctccgggc ggggaccgac
    23101 acccagtgcg cgggtgatga tgtggcgctg cgggtgcgtc gcagcgctct ggtcagagat
    23161 gtaccccgcg tcgatgagct cctgcacgac cgagtggtcc cgggtgacga gctccaactg
    23221 gcccccgtgc cagcggtaca cacgcgagtc gccgacgtgg aacaccgccc actgcggccc
    23281 cgcaccctcg tccaccaggg cgacgccggc gaccgtcgtc cccgcgccgg ccttgtccgg
    23341 cccctggaac gcgcggatct cgccgtcggc ccgctgcaac gccagccgga tcgcctcgac
    23401 ggtcgtcgtc tcggaccccg tcaacgaccg cagcgcctcg acgaccgcct ccgcagccgc
    23461 agcgcctccg acgtgacccc ccatgccgtc tgcgaccgcg aacaccggcg gagcggccag
    23521 gtgtcggtcc tggttgtcct cccgctggcc cacggcggtc gccgctcccc acgtcagctc
    23581 gaccggcggc atccacgctc cacgacacgt atcgacgaca ggacgccccg tggggaagac
    23641 gaggtggggt gagcgtagaa ggtcggcgac acaccggcag gtcgcacatc ccgcgacccg
    23701 ccggccggca cgccgtcgcc ctccgcgcgg cggagaatgg gccgcgatgc gctcttcccg
    23761 cctcggtgcc gtcgtcggcg ccctgatctg cctgttgacc accgcctgcg cggcgccgac
    23821 cgccggcccc gggacggcgc ccggtacgtc cggctccgcg cccccgccca ccccgagccc
    23881 ggagaccgac ccggtcgacg cggccctcgc cgacctggac cgccgcgagc aggtcgccca
    23941 gctcatcgtc gtcggggtcg cgctcaccga cctctccccc gccgacgcgt tcgccgcagg
    24001 gggcctgggt ggcgtcttcc tccagggccg cagcagcatc cccgcggacg agctggccac
    24061 cgagaccgcg cggtgggcgg aggcggcacc ggggccgcgc ccctggatcg gcgtcgacca
    24121 ggagggcggc gccgtccaga cgctctccgg cccgggcttc gccgacctcc cgtcggccgc
    24181 ccgccagggc cgcatgccgg ccgaggaact ggccggcctc gccgacgaca tgggcgcatc
    24241 gctgagcagc gcgggcatca acctcaacct ggcgccggtc gtcgacgtcg tccccgaggg
    24301 caccgaggac gccaacgcgc ccatcggtgc ctgggaccgc cagtacggca gcaccgccga
    24361 cgccgtcagc accgccgccg gaaccgtcgc cgacggcctg gccgcgcacg gggtcacccc
    24421 cacgctcaag cacttccccg gcctcggccg ggtgcaggag aaccccgaca agagccgcga
    24481 tgccaccgac gacgtcacca ccggcgacga cgaccaggtc gccgccttcg gcacgctcgc
    24541 cggctcggac gccgagccct tcgtgatgat gtcgtcggcc acctacaccc ggatcgaccc
    24601 gagcacgccg gccctcttct cccccgtcgt cgtcaccgac ctgctgcgcg agcagctcgg
    24661 cttcgacggg gtggtcatct ccgacgacat cggcgcagct caggccgtcc aggacctgcc
    24721 ggccgacgag cgggtgatcc gcttcctcga ggccggaggc accctcatgc tcaccatgga
    24781 cgccggcctg gtgacggaga tgatcgacgc catcgtggcc cgcgccgaga gcgaccccgc
    24841 gttctccgcc acggtcgacg cggccgtccg gaccgcgctc accgccaagg ccgacgccgg
    24901 gctgctgccg gagtcctgag cggacgcccc tggtcgcgga aggtcctcag ccccagctgc
    24961 cgacggcccg cgcggcctcg ttcggatcgg cccacacccg gcggcgggcg gcgcgcgccc
    25021 gagcggccgc caccccggca cgcgggtccg agaggtacac cgcggcgatc gcggtgaaga
    25081 ccgccgtgaa gaccaggccg aggccgatcc ccagcgtgag gacgaggtac agcacggagg
    25141 agtcctttcg agggtcgaac gaccgccagc gcaggctcgc ccgccggcgg ttcgagctga
    25201 ggtgcgccga tgcactggtc gtggccgagg gagcctccgg tcggccacag cgggattcca
    25261 caccgcaaca gtgcggcatc ggttctgcac tcaaggtacc cagccgtcct ccgccgcgac
    25321 gggcgacgaa gccgaccgtg agcggactca ccgccggcga gcgccaggac gacgaccact
    25381 ccgcgcgccc ggcggctgcg ccggacgtgg acgaccgaca gcatgaggca gccgacgacg
    25441 aaccaggacc cgg
//
