LOCUS       NZ_FNHE01000010        21625 bp    DNA     linear   CON 03-MAY-2024
DEFINITION  Geodermatophilus siccatus strain DSM 45419, whole genome shotgun
            sequence.
ACCESSION   NZ_FNHE01000010
VERSION     NZ_FNHE01000010.1
KEYWORDS    WGS; RefSeq.
SOURCE      Geodermatophilus siccatus
  ORGANISM  Geodermatophilus siccatus
            Bacteria; Actinomycetota; Actinomycetes; Geodermatophilales;
            Geodermatophilaceae; Geodermatophilus.
REFERENCE   1
  AUTHORS   Varghese,N. and Submissions,S.
  TITLE     Direct Submission
  JOURNAL   Submitted (17-OCT-2016) DOE - JOINT GENOME INSTITUTE, LBNL, 2800
            Mitchell Drive, Walnut Creek, CA 94598, 94598, USA
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_900103785.1-RS_2024_05_03
            Annotation Date                   :: 05/03/2024 01:00:42
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 4,951
            CDSs (total)                      :: 4,891
            Genes (coding)                    :: 4,846
            CDSs (with protein)               :: 4,846
            Genes (RNA)                       :: 60
            rRNAs                             :: 2, 4, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 2, 1 (5S, 16S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 48
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 45
            CDSs (without protein)            :: 45
            Pseudo Genes (ambiguous residues) :: 0 of 45
            Pseudo Genes (frameshifted)       :: 11 of 45
            Pseudo Genes (incomplete)         :: 37 of 45
            Pseudo Genes (internal stop)      :: 5 of 45
            Pseudo Genes (multiple problems)  :: 8 of 45
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 16:54:22
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 14228
            Orig. end                         :: 35853
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            FNHE01000010.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..21625
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="ranthipeptide"
                     /region_number="1"
                     /rules="(TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085
                     or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /tool="antismash"
     cand_cluster    1..21625
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /kind="single"
                     /product="ranthipeptide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21625
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:11625](+)"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11625
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="1"
     gene            577..1245
                     /locus_tag="BLS21_RS17720"
                     /old_locus_tag="SAMN05660642_03592"
     CDS             577..1245
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012950895.1"
                     /locus_tag="BLS21_RS17720"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05660642_03592"
                     /product="response regulator transcription factor"
                     /protein_id="WP_091221507.1"
                     /transl_table=11
                     /translation="MAERTAETIRLVIVDDHAIVRQGLRSILEREPDIEVVGEAASAGE
                     ALDLVAASRPHIVLLDLKLSAGSDVAGLALCGQLTAATPAPGVLVVTTFLDQQLVLEAI
                     QRGARGYVLKDVDAVALVAAIRAVRRGESAFDSHSATMVVRSLAAPAPSPVAPAGPGLT
                     AREREVLTLLARGLSNEAIGRELYISATTAKFHVGNVMRKLAVSRRAEAVYAGSKLGLI
                     "
     gene            1355..2338
                     /locus_tag="BLS21_RS17725"
                     /old_locus_tag="SAMN05660642_03593"
     CDS             1355..2338
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1039: aldo/keto reductase family oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012950894.1"
                     /locus_tag="BLS21_RS17725"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05660642_03593"
                     /product="oxidoreductase"
                     /protein_id="WP_091221509.1"
                     /transl_table=11
                     /translation="MTTTAAGSGQVTLGDRTVHRVGFGGMKLSGPRFLGPPADREAALA
                     VLRRAVELGVTHVDTSGLYGPHVVNDLIREALHPYPEDLVIVTRVGARRTPEGGWEEAL
                     GADELRRSVEEECEHLGLDALHVANLRMPGLGEPEEGSLAEPFEALARLQQEGLVHGLG
                     VSHITGRQVAEARGIAPLACVQNHYNLIHRTDDGLVAELAREGIAYTALEGVSYTSFFP
                     MGEMGPAQSEVLGAVAQRVGASPLQVAMAWLLARSPNVLLIPGATTVAELEQALAAAEV
                     VLGPDDIAELDRIEGMGGPPPAPAWGGGGPGGRPPWGGGPGGRPPA"
     gene            2399..4621
                     /locus_tag="BLS21_RS17730"
                     /old_locus_tag="SAMN05660642_03594"
     CDS             2399..4621
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012926.4"
                     /locus_tag="BLS21_RS17730"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05660642_03594"
                     /product="glycoside hydrolase family 15 protein"
                     /protein_id="WP_217636186.1"
                     /transl_table=11
                     /translation="MFSRDVLHGRRPARALLGGAAVAGVLVLGGGGVAGLGVAAAQAAP
                     PAPGQPGVAATWAPGDKDGFGTAIGALDSTVWYTLEDGTLSEVFAPRIDTQSSRDTQFV
                     VTDGATFAEREDEATESVVELVDPRALVYRQVNTATSGRYRITKTYTTDPDRAAVLVDV
                     RFESLDGQPYQVYVLHDVGLGLNANDDTGRSADGRLLATDGALSSAVTATGGLTDTSSG
                     YLERSDGWTDLRDDFVLDDLWDAPTPGNVAQIGRTGLTGLDGGQQLTLALGFGTTEDDA
                     AQAAGQALDRGFDAALQAYTEGWHAYLDGLAPVPASAAQWRTEYQVSAMVIAASEDKTV
                     RGGFVASPGRPWAWADELQQFPVYHAVWSRDLYQHATALIAMGDVAAADRALDHLWTVQ
                     QRPDGSFPQNARLDGEPVFGGLQMDEVALPIVLAWQLGRTGPADWERVRLSADFLVAEG
                     PATGQERWENLGGYSPNTIAAEIAGLVTAADIARANGDGARADTYLATADEWRAGLAEW
                     TVTTTGPLSSEPYFLRITADGDADAGTQIQIADGGPLVDQREVLDPSFLDLVRLGVLPA
                     DDPVVTTTLRLVDEQLAYDALNGRFWHRASFDGYGERPDGTQWEPVDPGSRETIGRGWP
                     LLTGERGEYEVALGGEAAESTQERLDTMARSADDESLFMAEQVWDDQLPSAEGTEFVPG
                     EPTSSATPLSWTHAGFVRLAHAIDAGRPVDTPSVVACHFGTSLCQE"
     gene            complement(4685..6196)
                     /locus_tag="BLS21_RS17735"
                     /old_locus_tag="SAMN05660642_03595"
     CDS             complement(4685..6196)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF017569.4"
                     /locus_tag="BLS21_RS17735"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05660642_03595"
                     /product="VWA domain-containing protein"
                     /protein_id="WP_091221512.1"
                     /transl_table=11
                     /translation="MEGALHRFVRLLRLRGMRISTAEAIDAFDAAAAVGVSDRLALEAA
                     LGAALLKDRRDAEVFADTFARFFGLRAVVDADEGHGHAHDDLADTGELQRMTWSPDPAA
                     DVQEGHSHGKPVDIKEFFKPEDLAAQYNLHQEANKVDLASLTQQIVLSSESRGGPADDA
                     QKVQLEVSRLHDPGLPGDLVRGGGTQLDLELSVAQQQALRDWLADPVGDLDPEVAEALR
                     RQLAGVIEDLPELLAAHLQKLAEMTDVAVEERELARAPVEKVTEAERARIEESLRRLAT
                     SLHGGLTHKKRQSPRGRVDVARTMRRNLRYDGVPFRPVTTRLAEDKPRLVVVADVSLSV
                     RTTARFTLHVVHALQDLFAQVRTFAFVDDVVEITDLFDEHPLEHALGLVFGGDVIDVDA
                     SSDYGAVFATLAADHSGAFTRRSTLLVLGDGRGNGNAPRLDVFADLTRRVRETIWLTPE
                     PRYSWALGGCDLPAYAESCDRVEVIRDHSGLESWATDVVTRASSR"
     gene            complement(6198..7445)
                     /locus_tag="BLS21_RS17740"
                     /old_locus_tag="SAMN05660642_03596"
     CDS             complement(6198..7445)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012234.4"
                     /locus_tag="BLS21_RS17740"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05660642_03596"
                     /product="MoxR family ATPase"
                     /protein_id="WP_245700525.1"
                     /transl_table=11
                     /translation="MTVQPVPADAVPTSDFTSPDDVARAFAEHGYIADRRLATTTFVMS
                     RLAKPLLLEGPAGVGKTELAKTLAAATGRRLLRLQCYEGQDETKALYEWDYGKQLLYTQ
                     ILRDKAAELLEDTSTLADAVDRIAGADSAFFNERFLAPRPLLEAVRSEEPVVLLVDEVD
                     RADEALEAVLLEMLAEYQVSVPEIGTFVAKAPPYVVLTSNNTRDLSAALKRRCLHLFLE
                     YPDADRELEILRSKQTGLDDAAAQRLVEIVRGLRGLDLRKAPSISETIDWARTLAVLGV
                     SELDAGVLGDTVSVVAKYERDVQRSREALPRLVDPNATVPESLGHGHDHAHGHPHSHGA
                     HTHGGHSHDHDHDHEDDGRRARAAKDRPGRHDENYYGQQAPTESGTPAPPRQVRAGQGA
                     RSFAPNRGGGTRRRPV"
     gene            complement(7665..8957)
                     /gene="mdo"
                     /locus_tag="BLS21_RS17745"
                     /old_locus_tag="SAMN05660642_03597"
     CDS             complement(7665..8957)
                     /EC_number="1.1.99.37"
                     /EC_number="1.2.98.1"
                     /GO_function="GO:0016614 - oxidoreductase activity, acting
                     on CH-OH group of donors [Evidence IEA]"
                     /GO_function="GO:0050661 - NADP binding [Evidence IEA]"
                     /GO_process="GO:0046170 - methanol catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="mdo"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fe-ADH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:TIGR04266.1"
                     /locus_tag="BLS21_RS17745"
                     /note="This methanol dehydrogenase is considered a
                     nicotinoprotein, since its NADP cofactor remains is not
                     dissociable, but instead remains permanently bound. A
                     member of this family has been shown to act as a
                     formaldehyde dismutase, able to convert two molecules of
                     formaldehyde (plus one water molecule) into one of methanol
                     and one of formate, with no net change in its redox state.
                     More recently, it was shown in Mycobacterium smegmatis that
                     this enzyme is critical to ethanol utilization, for which
                     the biosynthesis of the cofactor-like electron carrier
                     mycofactocin is also required; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /old_locus_tag="SAMN05660642_03597"
                     /product="NDMA-dependent methanol dehydrogenase"
                     /protein_id="WP_091221515.1"
                     /sec_met_domain="Fe-ADH (E-value: 2.4e-106, bitscore:
                     349.3, seeds: 218, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKVEELLKPFPIKEFHPFPRALMGPGAHEIIGPEALKLGFKRTLI
                     MTSGLRGTDVVHKIAESMKYHGLDVVVYDKVESNPKDYNVMDAVALYQENECDSFVSIG
                     GGSSHDACKGARISVAHDGRSVNEFEGFNQSENPRNPPHIAVSTTAGTGSETSWAYVIT
                     DTTTDPDNPHKYVAFDDTSVTTLAIDDPVLYYDCPIDYTAQCGFDVLAHASEPYVSRLN
                     FQPSLGNALYAIKLTSEHLRQAVWNGQDLAGREGMMYAQYIAAQAFNSGGLGIIHSISH
                     AVSAFYDTHHGLNNAIALPRVWAFNMPTQYQRFADIAEAMGVDTHGMTAPQAADAALAA
                     AIRLLRDVGIPEKFTDVTQDSYSKNRLGQGPTKFYENASVIKGDDTDVDRITNHVLGDA
                     CTPGNAKECTFETVRPVVEHCMNGDLDDLLS"
     gene            complement(9168..9767)
                     /gene="mftR"
                     /locus_tag="BLS21_RS17750"
                     /old_locus_tag="SAMN05660642_03598"
     CDS             complement(9168..9767)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0036042 - long-chain fatty acyl-CoA
                     binding [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene="mftR"
                     /gene_functions="regulatory (smcogs) SMCOG1215: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012950893.1"
                     /locus_tag="BLS21_RS17750"
                     /note="MftR, the mycofactocin system transcriptional
                     regulator, is an uncharacterized TetR family DNA-binding
                     transcription factor. Its role is inferred by context. It
                     occurs as part of the biosynthesis locus for mycofactocin,
                     a partially characterized electron carrier derived from the
                     terminal Val-Tyr dipeptide of the precursor peptide MftA,
                     through a radical SAM enzyme-mediated process; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology."
                     /old_locus_tag="SAMN05660642_03598"
                     /product="mycofactocin system transcriptional regulator"
                     /protein_id="WP_091221519.1"
                     /transl_table=11
                     /translation="MTEAPADVRGDTRARVQQAALELFTRTGFEQVTADEIADAAGISR
                     RTFFRCFATKADAVWGEFEAHVARLEALLAATRDDQPVLASICAAYVEVNDYAAEDLPT
                     LRQRMALILGEPALQAHSQVRYADVDRVVAEHVARRTGQSPGALLPRLVATTTRAAATT
                     AFEVWLADGTTTLAAALHAAFDQLALGFPGLRTPTG"
     misc_feature    9833..9847
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 16.25"
                     /tool="antismash"
     misc_feature    9866..9881
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: weak, score: 16.05"
                     /tool="antismash"
     gene            9891..10016
                     /gene="mftA"
                     /locus_tag="BLS21_RS17755"
                     /old_locus_tag="SAMN05660642_03599"
     CDS             9891..10016
                     /GO_function="GO:0009055 - electron transfer activity
                     [Evidence IEA]"
                     /GO_process="GO:0140604 - mycofactocin biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="mftA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012950892.1"
                     /locus_tag="BLS21_RS17755"
                     /note="Mycofactocin is a small molecule electron carrier
                     derived from the final two amino acids, Val-Tyr, of MftA,
                     the mycofactocin precursor. It plays a role in redox
                     homeostasis and the metabolism of alcohols and aldehydes in
                     Actinobacteria, including Mycobacterium tuberculosis;
                     Derived by automated computational analysis using gene
                     prediction method: Protein Homology."
                     /old_locus_tag="SAMN05660642_03599"
                     /product="mycofactocin precursor MftA"
                     /protein_id="WP_091221520.1"
                     /transl_table=11
                     /translation="MPENDDTQAVSSREAAPAVEEALVEESLVEEVSIDGMCGVY"
     gene            10001..10387
                     /gene="mftB"
                     /locus_tag="BLS21_RS17760"
                     /old_locus_tag="SAMN05660642_03600"
     CDS             10001..10387
                     /GO_process="GO:0140604 - mycofactocin biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="mftB"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: Mycofactocin_RRE"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014743322.1"
                     /locus_tag="BLS21_RS17760"
                     /note="MftB, a small protein, is a peptide chaperone that
                     assists the radical SAM enzyme MftC in performing two
                     modifications to the C-terminal Val-Tyr dipeptide of the
                     mycofactocin precursor peptide, MftA. MftB's role is
                     analogous to the role of PqqD in the biosynthesis of PQQ, a
                     cofactor that derives entirely from a Tyr and a Glu in the
                     precursor PqqA.; MftB, a small protein, is a peptide
                     chaperone that assists the radical SAM enzyme MftC in
                     performing two modifications to the C-terminal Val-Tyr
                     dipeptide of the mycofactocin precursor peptide, MftA.
                     MftB's role is analogous to the role of PqqD in the
                     biosynthesis of PQQ, a cofactor that derives entirely from
                     a Tyr and a Glu in the precursor PqqA.; MftB, a small
                     protein, is a peptide chaperone that assists the radical
                     SAM enzyme MftC in performing two modifications to the
                     C-terminal Val-Tyr dipeptide of the mycofactocin precursor
                     peptide, MftA. MftB's role is analogous to the role of PqqD
                     in the biosynthesis of PQQ, a cofactor that derives
                     entirely from a Tyr and a Glu in the precursor PqqA;
                     Derived by automated computational analysis using gene
                     prediction method: Protein Homology."
                     /old_locus_tag="SAMN05660642_03600"
                     /product="mycofactocin biosynthesis chaperone MftB"
                     /protein_id="WP_245700527.1"
                     /sec_met_domain="Mycofactocin_RRE (E-value: 1.7e-32,
                     bitscore: 105.3, seeds: 14, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRGVLIDTPVAAPAEQVREAGAALLPGSVAAAPAPIADFDPSLPW
                     RRARSVALRPEPFGALVYHFGNRKLSFLKSKTLVRVVETLADHPTASATLAACEVPEAQ
                     RPAYLKALADLARSQMIERREPSA"
     aSDomain        10127..10363
                     /aSDomain="Mycofactocin_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="Stand-alone RRE protein in a mycofactocin
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_BLS21_RS17760_Mycofactocin_RRE.1"
                     /evalue="2.20E-33"
                     /identifier="RREFam016.1"
                     /label="BLS21_RS17760"
                     /locus_tag="BLS21_RS17760"
                     /protein_end="121"
                     /protein_start="42"
                     /score="105.3"
                     /tool="antismash"
                     /translation="LPWRRARSVALRPEPFGALVYHFGNRKLSFLKSKTLVRVVETLAD
                     HPTASATLAACEVPEAQRPAYLKALADLARSQMI"
     gene            10384..11625
                     /gene="mftC"
                     /locus_tag="BLS21_RS17765"
                     /old_locus_tag="SAMN05660642_03601"
     CDS             10384..11625
                     /EC_number="1.3.98.7"
                     /EC_number="4.1.99.26"
                     /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /GO_process="GO:0031179 - peptide modification [Evidence
                     IEA]"
                     /GO_process="GO:0140604 - mycofactocin biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="mftC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: PF04055"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: TIGR04085"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: SPASM"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PTHR43273"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) QueE"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012950890.1"
                     /locus_tag="BLS21_RS17765"
                     /note="MftC is a radical SAM/SPASM enzyme that catalyzes
                     the first two steps in biosynthesis of the electron carrier
                     mycofactocin from the terminal Val-Tyr dipeptide of the
                     precursor peptide MftA.; MftC is a radical SAM/SPASM enzyme
                     that catalyzes the first two steps in biosynthesis of the
                     electron carrier mycofactocin from the terminal Val-Tyr
                     dipeptide of the precursor peptide MftA; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology."
                     /old_locus_tag="SAMN05660642_03601"
                     /product="mycofactocin radical SAM maturase"
                     /protein_id="WP_091221523.1"
                     /sec_met_domain="PTHR43273 (E-value: 6.2e-41, bitscore:
                     134.3, seeds: 35, tool: rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 6.3e-27, bitscore: 88.7,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 9.1e-07, bitscore: 23.0,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="QueE (E-value: 8.5e-10, bitscore: 32.2,
                     seeds: 32, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 1.2e-15, bitscore:
                     51.5, seeds: 281, tool: rule-based-clusters)"
                     /sec_met_domain="SPASM (E-value: 2.2e-06, bitscore: 21.9,
                     seeds: 166, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAVLPSRPAGERPTGGRLIDQFEYGLDAPICLTWELTYACNLAC
                     AHCLSSSGRRDPRELSTAEAEAVIDELHRMQVFYVNVGGGEPTVRPDFWHLLDYAIGHD
                     VGVKFSTNGVKLDRARAEQLARTDYVDVQISLDGATAEVNDRVRGTGSYATAVRALENL
                     AEAGMKDFKVSVVVTRENVSQLDEFRALTDRYGAQLRITRLRPSGRGADVWDELHPTQA
                     QQRELYSWLLANGEEVLTGDSFFHLSAYGEALPGLNLCGAGRVVCLIDPVGDVYACPFA
                     IHEQFLAGNVRDGGGFQRVWQQSDLFQDLRSPQTGGACTRCAHFDACRGGCMAAKFFTG
                     LPLDGPDPECVQGYGESALAARDADLVTPRSHLDHSHKGPVRGQPTLLGMPSIPRVAPA
                     KMCDESPLAGLELR"
     gene            11586..13448
                     /locus_tag="BLS21_RS17770"
                     /old_locus_tag="SAMN05660642_03602"
     CDS             11586..13448
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1217: NADH:flavin oxidoreductase/NADH oxidase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012950889.1"
                     /locus_tag="BLS21_RS17770"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05660642_03602"
                     /product="mycofactocin system FadH/OYE family
                     oxidoreductase 1"
                     /protein_id="WP_245700529.1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 4.4e-09, bitscore:
                     29.7, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRRVAAGRARAALTGLLDPLVLAGRTAPSRVLFGPHETNLGRGRA
                     LSERHVAYYARRAAGGCGVVVTETASVHGSDWPYERAPLAADCGPGWADVVAACRPHGA
                     LVLASLGHTGAQGSSGHAQTALWAPSAVPDVVTREVPVAMEQPEIDALVAGSAAGARIA
                     VGAGVDGVEVDAGPRSLLRQFASGLTNHRADGYGADRLRLLREVLAAVRAELGPGRALA
                     LRLSCDEEAPWAGITPDLAVGHVRELAPLVDLLVVVRGSGPAPSAYRPDGHTAPGFNTD
                     LTRSVRAAAGGTPVVLQGSVVDVAAAQRALDDGVADAVEMTRAQIADAELVRRARAGVR
                     VRPCTLCNQACQVRDVRNPLVSCVADPSDEGALAAGAGRRVTVVGGGPAGLEAARVLAS
                     AGAEVRLVERTGRLGGALRLVAALPGRARFADLADWLAGEVARLGVRVELGTTAEGGDV
                     VATGAHRPPGGSAADVLAGAELPPGPVVVHDPVGGPVGVGVAELLAAAGREVTLVTPDA
                     VVGERLGGDLAPAGARLARAGVRRETSSRLRSAGGGVAVLADRWTGEERTVPCAVVVDA
                     GPGLPGDVPPGVPAAGDVVAPRTVLEAVLEGRRAARALLAAPPR"
     gene            complement(13622..14101)
                     /locus_tag="BLS21_RS17775"
                     /old_locus_tag="SAMN05660642_03603"
     CDS             complement(13622..14101)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012950888.1"
                     /locus_tag="BLS21_RS17775"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05660642_03603"
                     /product="pyridoxamine 5'-phosphate oxidase family protein"
                     /protein_id="WP_091221525.1"
                     /transl_table=11
                     /translation="MSAEDTRKVAELIKGQKFGFLTTTTPEGKLTSRPMALQEVEFDGD
                     LWFFAEQSAEWLTHISRSPQVNVGVGSGGTWVSLTGEAVVVADVAKKKELWNSGVEAWL
                     PQGPEDPSVVLVKVDGDSAEYWDSPGNRLATAYSFVKAKVTGDQPDTGEKKVVDL"
     misc_feature    14300..14315
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: medium, score: 23.92"
                     /tool="antismash"
     misc_feature    complement(14301..14314)
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 17.39"
                     /tool="antismash"
     gene            14308..14691
                     /locus_tag="BLS21_RS26350"
                     /old_locus_tag="SAMN05660642_03604"
     CDS             14308..14691
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF014741.4"
                     /locus_tag="BLS21_RS26350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05660642_03604"
                     /product="DUF222 domain-containing protein"
                     /protein_id="WP_342705879.1"
                     /transl_table=11
                     /translation="MIDPAGGVVDELFASLDALAAEDLAPLFGPALLERLRPLLVAQNR
                     LAAEVARTVRACEVSGAAEVDGLKTMGPWLRGHGHLSAAEAARVVRPGRALAHLPAMAA
                     AFAAGQVTGEQVAAIAGWPSPSP"
     gene            14670..15557
                     /locus_tag="BLS21_RS17780"
                     /old_locus_tag="SAMN05660642_03605"
     CDS             14670..15557
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF014741.4"
                     /locus_tag="BLS21_RS17780"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05660642_03605"
                     /product="HNH endonuclease signature motif containing
                     protein"
                     /protein_id="WP_342705880.1"
                     /transl_table=11
                     /translation="MAEPEPLTRAAAQEVELAVVDALLTGVAVAAPCADVAKAVAHYLD
                     RLDTDGPEPDPTEGRRLVIAKHADRSVSGRFDLDTVGGERLQAALESLVQAGRCAADER
                     TRAQRLADALVQLCDNQLAAGTLPTLRGHKPQVIVTLGIEDLVDPATGRGAAKTGFGAA
                     ISAARARWLACDGQVTRIVLGPDGVPLEHGRTVRLFPAHVRRAAELRDGGCVFAGCSAP
                     TWWCDVHHVLAWVDGGATDLANAALLCERHHTKVHHGSRVERRPDGRWRTWRPDGTEIR
                     TGPGRTGPPLASAA"
     gene            complement(15666..16043)
                     /locus_tag="BLS21_RS17785"
                     /old_locus_tag="SAMN05660642_03606"
     CDS             complement(15666..16043)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012950886.1"
                     /locus_tag="BLS21_RS17785"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05660642_03606"
                     /product="YchJ family protein"
                     /protein_id="WP_091221528.1"
                     /transl_table=11
                     /translation="MAPRRCPCGTGLPYAECCGRLHDGTATAATAEQLMRSRYSAFAVG
                     DPAYLLATWHPSTRPPSLELDPTVRWTGLDVLATSDGGLLAAEGTVEFRAWYRHEGETG
                     SQHEVSRFLREDGAWRYLDGR"
     gene            complement(16069..16500)
                     /locus_tag="BLS21_RS17790"
                     /old_locus_tag="SAMN05660642_03607"
     CDS             complement(16069..16500)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="BLS21_RS17790"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="SAMN05660642_03607"
                     /product="SPOR domain-containing protein"
                     /protein_id="WP_139177196.1"
                     /transl_table=11
                     /translation="MATRGVRRTVWGVAGVVVAALVAAAAFVVTSDPRRDIDLGAWVEP
                     GDSWARTAMPNARWATDELCGGDLPCRQAVRSDTLTMYRFADRDDAIAVARRFAGEAYL
                     SGWIVVRFEPGALTRAQRSEFAAALDCLHVGTTEDGVEC"
     gene            16568..18493
                     /locus_tag="BLS21_RS17795"
                     /old_locus_tag="SAMN05660642_03608"
     CDS             16568..18493
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012950885.1"
                     /locus_tag="BLS21_RS17795"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05660642_03608"
                     /product="mycofactocin system FadH/OYE family
                     oxidoreductase 2"
                     /protein_id="WP_091221533.1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 3.4e-11, bitscore:
                     36.6, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRHLSAPLRVGPVTLPNRLVFPAHLTNYAVDGRFTERHAAYYAAR
                     AAGGAGLVVTEELSTDPADRPYEKLVHGCDPDALPGMRLVADAVHAHGVPVFAQLNHNG
                     GQSDSLHTRTPVLAPSPVPDPLFREVPREASTADLARLVAGYADVAARCAAAGFDGVEV
                     QASQSSLVRQFLSRATNLRTDRYGGPLESRARFLVEVLTAVREALGPGRALGVRLADEE
                     GRDGGTTLAEAVATARLLVERGLVDSVSTTVGVATATLDRVVPPMTTPPGYARYLSAAI
                     RAAVDVPVIGVGRFLTPAQAERALAMSDCDLVGAVRAQIADPEFAAKALTGRDGEVRRC
                     LGCNQECVGRVGLNRPLGCVTNPRAGREAPLPAPERRRRVLVVGGGPAGLRAAATAAAR
                     GHAVTVWEQATDTGGAIRVAASAPGREGLRPLVDDLAAECARTGVAVRTGVRATVEAVR
                     AEAPDVVVLATGARPLRPDWAGDGDRVVDVRDVLTGAADPAGAVLVVDDLGAAAATSVA
                     ELLAARGCTVEVVTAALVVGQDLGLTLDRPGWERRAAALGIRRTTERLVTAVDGRAVRL
                     LHHPTGAVEERTVDWLVVATAPRADDGLWHALRDSGLEVHRVGDCLAPRRAGAATLDGD
                     RVGRAV"
     gene            18508..19221
                     /gene="mftE"
                     /locus_tag="BLS21_RS17800"
                     /old_locus_tag="SAMN05660642_03609"
     CDS             18508..19221
                     /GO_process="GO:0140604 - mycofactocin biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="mftE"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012950884.1"
                     /locus_tag="BLS21_RS17800"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05660642_03609"
                     /product="mycofactocin biosynthesis peptidyl-dipeptidase
                     MftE"
                     /protein_id="WP_245700531.1"
                     /transl_table=11
                     /translation="MTDAVPRTRLAGATWPDLPERPLLLVPLGAVEQHGHHLPLATDTT
                     VACAVAEAAVDDLDGALLAPALAYGASGEHEDFPGTVSIGTEALTGLLVEYGRSACRWV
                     GRLVLVNGHGGNLDALRTAGAQLRAEGREVAWFPCGAAGADAHAGRTETSLMLHVEPEE
                     VREDRAVAGETAPIDELLPRLRAEGVRAVSPTGVLGDPAGASAEEGAELLAGMAGRLTA
                     AVRAWDVDPAGRLRG"
     gene            19260..19802
                     /locus_tag="BLS21_RS17805"
                     /old_locus_tag="SAMN05660642_03610"
     CDS             19260..19802
                     /EC_number="3.-.-.-"
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012950883.1"
                     /locus_tag="BLS21_RS17805"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05660642_03610"
                     /product="isochorismatase family cysteine hydrolase"
                     /protein_id="WP_091221538.1"
                     /transl_table=11
                     /translation="MGSPSGWLVVVDYQEVFRDPTSPWTTPRFDEIRPRLRSLVEAFGD
                     RVVFTRFVVPDEPTGAWADYYAKYDYFTQDHAIPLFQLSEDPGDRPVVDAPTFGKWVPA
                     VAELVGDGPVVVAGVATDCCVLSTVLPAADAGVLVRVVSDACAGADDEAHDDTMRILGC
                     YAPLVEVTTTAEVLAGA"
     gene            19799..21337
                     /gene="mftF"
                     /locus_tag="BLS21_RS17810"
                     /old_locus_tag="SAMN05660642_03611"
     CDS             19799..21337
                     /GO_process="GO:0140604 - mycofactocin biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="mftF"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012950882.1"
                     /locus_tag="BLS21_RS17810"
                     /note="Members of this protein family, MftF, are
                     glycosyltransferases, members of PF00535 (glycosyl
                     transferase family 2). The encoding gene is found as part
                     of the mycofactocin cassette, in Mycobacterium
                     tuberculosis, many other Actinobacteria, and occasional
                     members of other lineages. Mycofactocin itself, a putative
                     redox carrier, is a heavily modified derivative of the
                     C-terminal Val-Tyr dipeptide of the mycofactocin precursor
                     MftA (TIGR03969); Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05660642_03611"
                     /product="mycofactocin biosynthesis glycosyltransferase
                     MftF"
                     /protein_id="WP_091221541.1"
                     /sec_met_domain="Glycos_transf_2 (E-value: 2.4e-20,
                     bitscore: 66.8, seeds: 256, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSGGLAVAAPPPDRLPDGTAVRLDARVRSRDGGTTLLGGSPLRLL
                     RLHPRARDLLRTDRLVVRDATTAALAARLLDAGLAHPEPDGDPVGELTVVVPVKDRPAE
                     LARLLTALRADPDTAAVPVLVVDDGSADPAAVTAVAGRHGARVLRHATARGPAAARNAG
                     LRAASTPLVAFLDSDCVPLAGWSGPLVRLPADPRLALVAPRITALPSDGGGWVAPYEAT
                     VSALDMGPDPAPVAPGTAVSYLPSAAMVARRDALGDGFDESMRVAEDVDLVWRLVAAGW
                     RVRYEPSAAVAHEHRAATGEWLRRRAFYGTGAALLAARHGAAVAPVVLSPWSAAAWALA
                     LTGRRSGALGCAAVLAVATARLAPRLARPGQRAPVGLAAVLVVRGSAAAGRTLARSVTR
                     HHWPLALVAAAVSRRARRLAAAAAVADAVLAWWPHRRRVGLLRFAAGRRLEDLAYGAGL
                     WAGALRAGDPRALLPARPAPIPPPNRLGTTGSLVESRGSGHDGRTMDPSPRTTP"
ORIGIN
        1 tctcggcggg gatgacgatc gagtggtgcc ggccggaggt ggcccaccac agcgaggtct
       61 acgagcggct cgggcacgcc aaggcgctga cccgcgaggc ggtggagcgg ctgcgcggcg
      121 ccatccacgc gctctcctcc gacggccacg gggacggtga cgggctgccc gcgctgctgg
      181 gccggctctc cgacgtcgcc ccggtgccgg gcctggccgt cgccgtccgg gtggaggggc
      241 gcccgcgcga gctgcccccg gaggtcgagc actcgctgtt ccggatcgcc tcggagtgcc
      301 tgttcaacac cgcccggcac gcgcaggcca cccggagcac cgtgcggctg gcctaccggt
      361 ccgacgagct gcggctctcg gtcgccgacg acggctgcgg cgaccccgac gtgctgcgcc
      421 gggcgctgcg ggcctcggga cgccgggacg acgggtacca ccgcgggctg ggcaacatcg
      481 cctcccgctg ccgggagatg ggggcgacgg tgcggatcac gcgggcccgg atgggcgggg
      541 tgcgggtgga ggtccggatg ccgtgggacg ccgtcgatgg ctgagcgcac cgcggagacc
      601 atccggctgg tcatcgtcga cgaccacgcg atcgtccggc aggggctgcg ctcgatcctg
      661 gagcgcgagc ccgacatcga ggtggtcggc gaggcggcgt ccgccgggga ggcgctggac
      721 ctggtggccg ccagccgccc gcacatcgtg ctgctcgacc tgaagctctc ggccggctcc
      781 gacgtggccg gcctggccct gtgcgggcag ctcaccgccg cgacaccggc ccccggcgtc
      841 ctggtggtga cgaccttcct cgaccagcag ctggtgctcg aggcgatcca gcgcggcgcc
      901 cgcggctacg tgctcaagga cgtcgacgcg gtcgcgctgg tcgcggcgat ccgggcggtg
      961 cgccgcgggg agagcgcctt cgacagccac agcgcgacga tggtggtgcg ctcgctggcc
     1021 gcccccgcgc cgtcccccgt ggcccccgcc ggtccgggcc tcaccgcgcg cgagcgcgag
     1081 gtgctcaccc tgctggcgcg cgggctgtcc aacgaggcga tcggcaggga gctctacatc
     1141 tcggcgacga cggcgaagtt ccacgtcggc aacgtgatgc gcaagctggc ggtctcccgc
     1201 cgcgcggagg ccgtctacgc cgggtccaag ttggggctca tctgacccga cacgcgcagg
     1261 acacgccgcg gccgccccac gtcccgtgac ggccgcgccg ggaggcgcac cggacccgtt
     1321 gaccgggaga cctccgcccc taggtttgcg cggcatgacg acgactgcag cgggctccgg
     1381 gcaggtcacc ctcggcgacc ggaccgtgca ccgggtgggc ttcggcggca tgaagctctc
     1441 cgggccgcgg ttcctcgggc caccggccga ccgggaggcg gcgctcgccg tcctgcgccg
     1501 ggccgtcgag ctgggcgtga cccacgtcga caccagcggc ctgtacggcc cgcacgtcgt
     1561 gaacgacctg atcagggagg cgctgcaccc ctatcccgag gacctggtga tcgtcacgcg
     1621 ggtcggcgcc cgccggacgc cggagggggg ctgggaggag gcgctcggcg cggacgagct
     1681 gcgccggtcg gtggaggagg agtgcgagca cctcggcctc gacgcgctgc acgtggccaa
     1741 cctgcggatg ccgggactcg gcgagccgga ggagggctcc ctcgccgagc cgttcgaggc
     1801 gctggcgcgg ctgcagcagg aggggctggt ccacggcctc ggggtcagcc acatcaccgg
     1861 ccggcaggtc gcggaggcgc ggggcatcgc gccgctggcc tgcgtgcaga accactacaa
     1921 cctgatccac cgcacggacg acggcctggt ggcggagctg gcgcgggagg ggatcgccta
     1981 cacggcgctg gagggcgtct cctacacgtc gttcttcccg atgggcgaga tgggcccggc
     2041 gcagtccgag gtgctggggg cggtcgcgca acgggtcggc gcgagcccgc tgcaggtggc
     2101 gatggcctgg ctgctggccc gctcgcccaa cgtgctgctc atccccggcg ccaccacggt
     2161 ggcggagctg gagcaggccc tcgcggcggc cgaggtggtg ctcggccccg acgacatcgc
     2221 ggagctggac cgcatcgagg gcatgggcgg acctcctccc gcgccggcgt ggggcggtgg
     2281 cggcccgggc ggccggcccc cgtggggcgg gggcccgggc ggtcggccgc ccgcgtgacc
     2341 cggcggccat ctccgcggag atggccgctg cgaccggcag aggacggagg aacagccggt
     2401 gttctccagg gacgtgctcc acggcaggcg cccggcgcgt gcgctcctcg gcggggccgc
     2461 cgtcgccggt gtcctcgtcc tcggtggcgg cggggtggcc gggctcggtg tcgccgcggc
     2521 gcaggcagcg ccgccggcgc cggggcaacc cggcgtggcg gcgacctggg caccggggga
     2581 caaggacggg ttcggcaccg cgatcggtgc cctggacagc acggtctggt acaccctcga
     2641 ggacggcacg ctcagcgagg tcttcgcccc gcggatcgac acgcagagtt cccgggacac
     2701 ccagttcgtc gtcaccgacg gcgccacctt cgccgagcgc gaggacgagg cgaccgagtc
     2761 cgtcgtcgag ctggtcgacc cccgtgccct cgtctaccgg caggtcaaca ccgcgaccag
     2821 cggccgctac cgcatcacca agacctacac caccgacccc gaccgggccg cggtgctcgt
     2881 cgacgtccgc ttcgagtccc tcgacgggca gccgtaccag gtgtacgtgc tgcacgacgt
     2941 cggactgggc ctgaacgcca acgacgacac cgggcgctcg gcggacggcc ggctgctggc
     3001 caccgacggt gcgttgagca gcgccgtcac cgccacgggc ggtctcaccg acacctccag
     3061 cgggtacctg gagcgcagcg acggctggac cgacctgagg gacgacttcg tcctcgacga
     3121 cctctgggac gcgccgaccc ccggcaacgt cgcccagatc gggcggaccg gcctcaccgg
     3181 tctggacggc gggcagcagc tgaccctggc cctcggcttc gggacgacgg aggacgacgc
     3241 cgcgcaggcc gccggccagg cgctggaccg gggcttcgac gccgccctgc aggcctacac
     3301 cgagggctgg cacgcctacc tcgacggcct cgccccggta cccgccagcg ccgcgcagtg
     3361 gcgcacggag taccaggtct cggcgatggt gatcgcggcg tcggaggaca agaccgtccg
     3421 cggcggcttc gtcgcctccc ccggtcggcc gtgggcgtgg gccgacgagc tgcagcagtt
     3481 ccccgtctac cacgccgtct ggtcgcgcga cctgtaccag cacgcgaccg cgctgatcgc
     3541 catgggcgac gtcgcggccg ccgaccgggc cctggaccac ctgtggacgg tgcagcagcg
     3601 ccccgacggg tcgttcccgc agaacgcgcg gctcgacggg gagccggtct tcggcgggct
     3661 gcagatggac gaggtcgccc tgccgatcgt gctcgcctgg cagctcggcc gcaccgggcc
     3721 ggcggactgg gagcgggtgc ggctctcggc ggacttcctg gtggccgagg ggccggcgac
     3781 ggggcaggag cggtgggaga acctgggcgg gtactcgccg aacaccatcg ccgcggagat
     3841 cgccggcctg gtcaccgccg ccgacatcgc ccgcgccaac ggcgacggcg cccgggcgga
     3901 cacctacctc gccacggccg acgagtggcg cgcgggcctg gcggagtgga cggtgaccac
     3961 caccggcccg ctgtcgtccg agccgtactt cctgcggatc accgccgacg gggacgccga
     4021 cgccggcacg cagatccaga tcgcggacgg cggcccgctg gtcgaccagc gcgaggtgct
     4081 cgacccgagc ttcctggacc tggtccggct cggggtcctg ccggccgacg acccggtcgt
     4141 caccaccacg ctgcgcctgg tcgacgagca gctggcctac gacgccctca acggccggtt
     4201 ctggcaccgg gcgagcttcg acgggtacgg ggagcggccc gacggcaccc agtgggaacc
     4261 ggtggacccg ggctcgcggg agaccatcgg ccgcggctgg ccgctgctga ccggggagcg
     4321 cggcgagtac gaggtggccc tcggtggcga agccgccgag agcacccagg agcggctgga
     4381 cacgatggcc cgctcggccg acgacgagtc gctgttcatg gccgagcagg tgtgggacga
     4441 ccagctgccg tcggccgagg gcacggagtt cgtgccgggg gagccgacgt cctcggcgac
     4501 gccgctgtcc tggacccacg ccggcttcgt ccggctggcc cacgccatcg acgccggccg
     4561 tcccgtggac accccgtccg tcgtggcctg ccacttcggg acgtcgctct gccaggaatg
     4621 acgggtcggc cccctgcagg gtcccgccac gagcctgcga gtgacggggg gcagggggtc
     4681 ttcctcagcg ggaggaggcg cgggtgacga cgtcggtcgc ccagctctcc agccccgagt
     4741 ggtcgcggat gacctcgacc cggtcgcagc tctccgcgta ggccggcagg tcgcagccgc
     4801 ccagcgccca cgagtagcgc ggctccgggg tcagccagat cgtctcgcgc acccggcggg
     4861 tcaggtcggc gaagacgtcc agccgggggg cgttgccgtt gccccggccg tcgccgagca
     4921 ccagcagcgt cgagcggcgg gtgaacgcgc cggagtggtc ggcggcgagc gtggcgaaca
     4981 ccgcgccgta gtcgctggag gcgtccacgt cgatgacgtc gccgccgaag accaggccca
     5041 gggcgtgctc cagcgggtgc tcgtcgaaca ggtcggtgat ctcgacgacg tcgtccacga
     5101 acgcgaaggt gcgcacctgc gcgaacaggt cctgcagcgc gtggacgacg tgcagcgtga
     5161 accgcgccgt cgtccgcacc gacaggctga cgtcggcgac cacgaccagc cgcggcttgt
     5221 cctcggcgag ccgggtggtg acgggccgga aggggactcc gtcgtagcgc aggttgcgcc
     5281 gcatcgtgcg ggcgacgtcg acccgcccgc gcggggactg ccgcttcttg tgcgtcagac
     5341 cgccgtgcag cgaggtggcc agccggcgca gcgactcctc gatccgcgcc cgctcggcct
     5401 cggtcacctt ctccaccggc gcgcgggcca gctcgcgctc ctcgacggcg acgtcggtca
     5461 tctcggcgag cttctgcagg tgcgcggcga gcagctcggg gaggtcctcg atgacgccgg
     5521 cgagctggcg ccgcagcgcc tcggccacct cggggtccag gtcgccgacc gggtcggcca
     5581 gccagtcccg cagcgcctgc tgctgggcca ccgacagctc caggtccagc tgggtgcccc
     5641 cgccgcgcac caggtcgccg ggcaggccgg ggtcgtgcag ccgcgacacc tccagctgca
     5701 ccttctgagc gtcgtccgcc ggcccgccgc ggctctccga ggacagcacg atctgctggg
     5761 tcagggaggc caggtcgacc ttgttggcct cctggtgcag gttgtactgc gccgcgaggt
     5821 cctcgggctt gaagaactcc ttgatgtcga ccggcttgcc gtggctgtgc ccctcctgca
     5881 cgtcggcggc ggggtccggc gaccaggtca tccgctgcag ctcgccggtg tcggccaggt
     5941 cgtcgtgggc gtgcccgtgc ccctcgtccg cgtcgaccac cgcccgcagg ccgaagaagc
     6001 gggcgaaggt gtcggcgaag acctcggcgt cccggcggtc cttgagcagc gccgcgccga
     6061 gcgcggcctc cagcgcgagc cggtcgctca ccccgaccgc ggccgcggcg tcgaaggcgt
     6121 cgatcgcctc cgccgtcgag atccgcatcc cgcgcagtcg cagcagccgg acgaaacggt
     6181 gcagggcccc ctccacctca gaccggccgc cgtcgcgtgc cgcccccgcg gttgggggcg
     6241 aacgagcggg caccctggcc ggcgcggacc tggcgcgggg gagccggcgt cccggactcg
     6301 gtcggcgcct gctggccgta gtagttctcg tcgtgccggc ccggccggtc cttcgccgcg
     6361 cgcgcccggc ggccgtcgtc ctcgtggtcg tggtcgtggt catgggagtg cccgccgtgg
     6421 gtgtgcgccc cgtgcgagtg gggatgcccg tgcgcgtggt cgtgcccgtg ccccagggac
     6481 tcgggcaccg tcgcgttcgg gtcgaccagc cggggcagcg cctcgcggga gcgctgcacg
     6541 tcgcgctcgt acttggcgac gacggagacg gtgtcgccga gcaccccggc gtccagctcg
     6601 ctcacgccca ggacggcgag ggtgcgggcc cagtcgatcg tctcggagat gctcggggcc
     6661 ttgcgcaggt ctaggccgcg cagcccgcgg acgatctcga ccagccgctg cgccgccgcg
     6721 tcgtccaggc cggtctgctt cgagcgcagg atctccagct cgcggtcggc gtcggggtac
     6781 tcgaggaaca ggtgcaggca gcggcgcttg agcgctgccg agaggtcgcg ggtgttgttc
     6841 gaggtcagga cgacgtaggg cggcgccttg gcgacgaacg tgccgatctc gggcaccgac
     6901 acctggtact ccgcgagcat ctccagcagc accgcctcca gggcctcgtc ggcgcggtcg
     6961 acctcgtcga ccagcagaac gaccggctcc tcggagcgga ccgcctccag cagcgggcgc
     7021 ggggcgagga atcgctcgtt gaagaacgcg ctgtccgcgc cggcgatccg gtcgacggcg
     7081 tccgccaggg tggaggtgtc ctccagcagc tcggccgcct tgtcccgcag gatctgcgtg
     7141 tagagcagct gcttgccgta gtcccactcg tagagggcct tggtctcgtc ctgcccctcg
     7201 tagcactgca ggcgcagcag cctgcgcccg gtggcggcgg ccagcgtctt ggccagctcg
     7261 gtcttgccga cgccggccgg gccctccagc agcagcggct tggccaggcg ggacatcacg
     7321 aaggtcgtcg tcgccagccg ccggtcggcg atgtagccgt gctcggcgaa ggcgcgggcg
     7381 acgtcgtcgg gggaggtgaa gtcggaggtg gggacggcgt cggcgggcac gggctggacg
     7441 gtcacgcgtt ctcctcgctg gcgctcgtcg tccgcgcgcc caggggtgct gtgtctccgg
     7501 gtgacctcgc gagctcggtc acgggttctc ctcgctggcg ctcgtcgtcc gcgcgcccag
     7561 gggtgctgtg tctccgggtg acctcgcgag ctcggtcacg ggctcctcgt cgggagggtg
     7621 gggcggggtg agcaggcggc gcaccccgcc ccaccggggt cggatcagct gaggaggtcg
     7681 tccaggtcgc cgttcatgca gtgctcgacc accgggcgga cggtctcgaa cgtgcactcc
     7741 ttggcgttgc ccggggtgca ggcgtcgccg aggacgtggt tggtgatgcg gtcgacgtcg
     7801 gtgtcgtcgc ccttgatcac cgaggcgttc tcgtagaact tggtcgggcc ctggcccagc
     7861 cggttcttcg agtagctgtc ctgggtgacg tcggtgaact tctccgggat gccgacgtcg
     7921 cgcagcagtc ggatcgcggc ggccagcgcc gcgtcggcgg cctggggggc ggtcatgccg
     7981 tgggtgtcga cccccatggc ctcggcgatg tcggcgaagc gctggtactg ggtgggcatg
     8041 ttgaacgccc acacgcgggg cagcgcgatg gcgttgttca ggccgtggtg ggtgtcgtag
     8101 aaggcgctca ccgcgtggct gatcgagtgg atgatgccga ggccgccgga gttgaacgcc
     8161 tgggcggcga tgtactgcgc gtacatcatc ccctcgcggc cggcgaggtc ctggccgttc
     8221 cacaccgcct ggcgcaggtg ctccgaggtg agcttgatgg cgtacagcgc gttgcccagg
     8281 gagggctgga agttcagccg ggagacgtag ggctcgctgg cgtgcgccag gacgtcgaag
     8341 ccgcactgcg cggtgtagtc gatcgggcag tcgtagtaga ggaccgggtc gtcgatcgcc
     8401 agcgtcgtca ccgaggtgtc gtcgaacgcc acgtacttgt gcgggttgtc cgggtcggtc
     8461 gtggtgtcgg tgatgacgta ggcccagctg gtctccgagc cggtgccggc cgtggtggag
     8521 acggcgatgt gcggcgggtt cctcgggttc tccgactggt tgaagccctc gaactcgttg
     8581 acgctgcggc cgtcgtgggc caccgagatc cgcgcgccct tgcaggcgtc gtggctggag
     8641 ccgccgccga tggagacgaa gctgtcgcac tcgttctcct ggtacagcgc cacggcgtcc
     8701 atgacgttgt agtccttggg gttcgactcg accttgtcgt agaccacgac atcgaggccg
     8761 tggtacttca tcgactcggc gatcttgtgg acgacgtccg tgccgcgcag gcccgacgtc
     8821 atgatcagcg tccgcttgaa gcccagcttg agggcctccg ggccgatgat ctcgtgcgcg
     8881 ccggggccca tcagggcccg cgggaacggg tggaactcct tgatcgggaa gggcttgagg
     8941 agttcttcga ccttcatggc ggggtccttc ctgcctgcct gcggggagcc gtcggcgcgg
     9001 acggtatgag cggcgttccc cctcgcggca ggggcggacg ggaggaaccg gccgtccgga
     9061 ggagcaggtc ggcccgcccg gtgaggtgca cctgcccgac cgggcagggg aaggacgccg
     9121 tcgcggccat gtccgcggcc atgtccgcgg agatggccgg gagggtgtca accggtcggc
     9181 gtgcgcaggc cggggaagcc cagggccagc tggtcgaagg ccgcgtgcag ggcggcggcc
     9241 agcgtcgtcg tcccgtcggc cagccagacc tcgaacgcgg tcgtcgcggc cgcgcgggtg
     9301 gtggtcgcga ccagccgggg gagcagtgct cccggggact ggccggtgcg gcgggcgacg
     9361 tgctcggcga ccacccggtc gacgtcggcg tagcggacct gcgagtgggc ctgcagcgcc
     9421 ggctcgccga ggatgagcgc catccgctgt cgcagggtcg gcaggtcctc ggcggcgtag
     9481 tcgttcacct cgacgtaggc cgcgcagatc gaggcgagca ccggctggtc gtcgcgggtg
     9541 gccgccagga gtgcctccag ccgggcgacg tgcgcctcga actcgcccca gaccgcgtcg
     9601 gccttggtgg cgaagcagcg gaagaacgtg cgccggctga tccccgcggc gtcggcgatc
     9661 tcgtcggcgg tgacctgctc gaagccggtc cgcgtgaaca gctccagggc cgcctgctgg
     9721 acgcgggcgc gggtgtcgcc gcgcacgtcc gcgggcgcct cggtcacggc cccatcttgc
     9781 gtcacggaca cgcgggggac ggcgcgccgc ggcgacagac cggtgttgcc ggtggcactc
     9841 ggtgtcacta acgtccccgc caccccgtaa tccagatcac aggaggcgcc gtgcccgaga
     9901 acgacgacac gcaggccgtg agcagccggg aggcggcccc cgcggtcgag gaggccctgg
     9961 tcgaggagtc cctcgtcgag gaggtctcga tcgacggcat gtgcggggtg tactgatcga
    10021 cacccccgtc gcggcgccgg ccgagcaggt gcgcgaggcc ggcgccgccc tcctcccggg
    10081 ctcggtcgcc gccgcgcccg cccccatcgc tgacttcgac ccgtcgttgc cctggcggcg
    10141 ggcccgttcc gtggccctgc gcccggagcc cttcggcgcg ctggtctacc acttcgggaa
    10201 ccggaagctc tccttcctga agtcgaagac gctggtccgg gtcgtggaga ccctcgccga
    10261 ccaccccacc gcctcggcca cgctggccgc ctgcgaggtg cccgaggccc agcgcccggc
    10321 gtacctgaag gcgctggcgg acctcgcccg ctcgcagatg atcgaacgcc gggagccctc
    10381 cgcatgactg ctgtcctgcc gtcccgtccc gccggcgaac gccccaccgg cgggcgcctg
    10441 atcgaccagt tcgagtacgg gctggacgcg ccgatctgcc tgacctggga gctcacgtac
    10501 gcctgcaacc tggcgtgcgc gcactgcctg tcctcgtcgg gacggcggga cccgcgtgag
    10561 ctgtccaccg ccgaggccga ggcggtgatc gacgagctgc atcggatgca ggtgttctac
    10621 gtcaacgtcg gcggcggcga gccgaccgtc cggccggact tctggcacct gctggactac
    10681 gccatcggcc acgacgtcgg cgtcaagttc tccaccaacg gcgtcaagct cgaccgggcc
    10741 cgcgccgagc agctggcccg caccgactac gtcgacgtcc agatctccct cgacggcgcg
    10801 accgccgagg tcaacgaccg ggtccgcggc accggctcgt acgccaccgc cgtccgcgcg
    10861 ctggagaacc tggccgaggc ggggatgaag gacttcaagg tctccgtcgt cgtcacccgg
    10921 gagaacgtct cccagctcga cgagttcagg gcgctcaccg accgctacgg cgcccagctg
    10981 cgcatcaccc ggctgcgccc gtcgggccgc ggcgccgacg tctgggacga gctgcacccc
    11041 acgcaggccc agcagcgcga gctctactcc tggctcctgg ccaacggcga ggaggtgctc
    11101 accggcgact cgttcttcca cctgtcggcc tacggcgagg ccctgcccgg cctgaacctg
    11161 tgcggcgccg gtcgcgtggt ctgcctgatc gacccggtgg gcgacgtcta cgcctgcccg
    11221 ttcgccatcc acgagcagtt cctcgccggc aacgtgcgcg acgggggcgg cttccagcgg
    11281 gtctggcagc agtcggacct gttccaggac ctgcgcagcc cccagaccgg tggcgcctgc
    11341 accaggtgcg cgcacttcga cgcctgccgg ggcggctgca tggcggccaa gttcttcacc
    11401 ggcctgccgt tggacggacc cgaccccgag tgcgtgcagg ggtacggcga gtcggccctg
    11461 gccgcccgcg acgccgacct ggtcacgccg cgcagccacc tcgaccactc gcacaagggc
    11521 ccggtccgcg gccagccgac cctgctcggc atgccgtcga tcccgagggt ggctccggcc
    11581 aagatgtgcg acgagtcgcc gctggccggg ctcgagctgc gctgacggga ctgctcgacc
    11641 cgctggtcct ggcgggccgg acggcgccct cccgggtgct gttcggcccg cacgagacca
    11701 acctgggccg cgggcgggcg ctctcggagc ggcacgtcgc ctactacgcc cgccgggccg
    11761 cgggcggctg cggcgtcgtg gtcaccgaga ccgcgtcggt gcacgggagc gactggccct
    11821 acgagcgggc gccgctggcc gccgactgtg gcccgggctg ggcggacgtc gtcgccgcct
    11881 gccgcccgca cggcgcgctg gtgctcgcct cgctcgggca caccggcgcg cagggcagct
    11941 ccgggcacgc gcagaccgcg ctgtgggcgc cgtccgcggt gcccgacgtc gtcacccgcg
    12001 aggtgccggt ggcgatggag cagccggaga tcgacgcgct ggtcgcgggc tccgcggcgg
    12061 gcgcccggat cgcggtcggc gccggtgtgg acggcgtgga ggtcgacgcc ggcccgcgct
    12121 cgctgctgcg gcagttcgcc tccggcctga ccaaccaccg ggccgacggg tacggcgccg
    12181 accggctgcg gctgctgcgc gaggtgctcg ccgccgtccg cgcggagctg ggccccgggc
    12241 gggcgctcgc gctgcgcctc tcctgcgacg aggaggcgcc ctgggccggg atcacgcccg
    12301 acctggctgt cgggcacgtc cgtgagctcg cgccgctggt cgacctgctc gtcgtcgtgc
    12361 gcggcagcgg gccggcgccc tcggcgtacc ggcccgacgg gcacaccgcg cccgggttca
    12421 acaccgacct cacccgctcc gtgcgggcgg ccgccggcgg gacgccggtc gtgctccagg
    12481 gctcggtcgt ggacgtcgcc gccgcgcagc gagcgctgga cgacggggtc gccgacgccg
    12541 tggagatgac ccgcgcgcag atcgccgacg ccgagctggt gcgccgggcg cgggccggcg
    12601 tccgggtgcg gccctgcacc ctgtgcaacc aggcctgcca ggtgcgcgac gtccgcaacc
    12661 cgctggtcag ctgcgtcgcc gacccgtccg acgagggcgc cctcgccgcc ggcgccggcc
    12721 ggcgggtgac ggtcgtcggc ggcgggccgg ccgggctgga ggccgcgcgg gtgctcgcgt
    12781 ccgcgggcgc cgaggtccgg ctggtggagc gcaccggccg gctcggtggg gcgctgcggc
    12841 tggtcgccgc gctgcccggg cgggcgcgct tcgccgacct cgccgactgg ctggccgggg
    12901 aggtggcgcg gctgggggtg cgggtcgagc tggggacgac cgcggagggc ggggacgtcg
    12961 tcgcgacggg cgctcaccgg cccccgggtg ggagcgccgc cgacgtgctg gccggcgcgg
    13021 agctgccgcc cggcccggtg gtggtgcacg acccggtcgg cgggccggtc ggcgtggggg
    13081 tggccgagct gctcgccgcg gcgggccgcg aggtcacgct ggtgaccccg gacgcggtgg
    13141 tcggcgagcg gctcggcggc gacctggcgc cggccggcgc ccggctggcg cgggcggggg
    13201 tgcggcggga gacgtcgtcc cggctgcgct cggccggcgg cggggtcgcg gtgctggccg
    13261 accgctggac gggggaggag cgcaccgtgc cgtgcgccgt cgtcgtcgac gcgggccccg
    13321 gcctgccggg cgacgtcccc ccgggggtgc cggccgccgg ggacgtcgtc gcgccgcgca
    13381 ccgtgctcga ggcggtgctc gaggggcggc gcgcggcgcg ggcgctgctc gccgcgccgc
    13441 cgcgctagcg gggcagcacg accagggccg cgcggtcgga cggcagcagg tcggccacgg
    13501 tcagcgtggc gaggaaggcg agcaggacgg cgatggtgag cagcgggcac ctccgagggg
    13561 acgccgtcca cggtggcgcg gccggctgga ggcccggtgc ggaccggctg ggagccggct
    13621 gtcagaggtc gacgaccttc ttctcacccg tgtcgggctg gtcgccggtg accttggcct
    13681 tcacgaagct gtacgcggtc gccagccggt tgccggggct gtcccagtac tcggcggagt
    13741 cgccgtcgac cttgaccagc acgaccgacg ggtcctccgg gccctgcggc agccaggcct
    13801 cgacgccgct gttccacagc tccttcttct tggcgacgtc ggcgacgacg acggcctcac
    13861 cggtgaggga gacccaggtg ccgcccgagc ccacgccgac gttgacctgc ggcgagcgcg
    13921 agatgtgggt cagccactcg gcgctctgct cggcgaagaa ccacaggtcg ccgtcgaact
    13981 ccacctcctg cagcgccatg ggacggctgg tcagcttgcc ctcgggcgtg gtggtggtga
    14041 ggaagccgaa cttctgcccc ttgatcagct cggcgacctt gcgggtgtcc tcggcgctca
    14101 tgggggtcct ctcggagtgc gcgatcaggt gtcgcccgac tcctgcccac ggccgtcggc
    14161 gctgacacac gcccgccacg ccgccgacga cgtgtcagcg gacagcgcga gcctcggctg
    14221 tcaaggcgcg tgtcgtatct gtggacgagc tattgacctg cggattcatc gtgaggccgc
    14281 gtcctcggcg cgctaggatt cgaacgcgtg atcgatccgg cgggaggtgt cgtggacgag
    14341 ctgttcgcct ccctcgacgc cttggccgcc gaggacctgg caccgttgtt cggcccggcg
    14401 ctgctggagc ggctgcggcc gctgttggtg gcgcagaacc ggctcgccgc cgaggtcgcc
    14461 cgcacggtgc gcgcgtgtga ggtgtcaggt gccgcggagg tcgacgggct caagaccatg
    14521 ggcccctggc tgcgcgggca cgggcacctg tcggccgcgg aggcggcgcg ggtggtgcgc
    14581 cccggccgcg cgctggcgca cctgccggcg atggccgccg ccttcgccgc cgggcaggtg
    14641 accggtgagc aggtggcggc catcgccggg tggccgagcc cgagcccctg acccgggcgg
    14701 cggcgcagga ggtggagctg gccgtggtcg acgcgctgct gaccggcgtg gcggttgcgg
    14761 ctccgtgtgc cgacgtggcg aaggcggtgg cccactacct ggaccggctc gatactgacg
    14821 gcccggagcc cgatccgact gagggccgcc ggctcgtcat cgcgaagcac gcggacaggt
    14881 cggtcagcgg ccgcttcgac ctcgacaccg tgggcgggga gaggctgcag gcggcgctgg
    14941 agtccctcgt ccaggccggc cgctgtgccg ccgatgagcg cacacgagcg cagcggctgg
    15001 ccgacgcgct ggtgcagctg tgcgacaacc agctggccgc cggcaccctg ccgacgctgc
    15061 gcgggcacaa gccgcaggtc atcgtgacgc tcggcatcga ggacctggtc gacccggcca
    15121 ccggccgcgg cgcggccaag accggctttg gggcggccat ctccgcggcg cgggcccgct
    15181 ggctggcctg cgacgggcag gtcactcgga tcgtgctggg cccggacggg gtgccgctgg
    15241 agcacggccg cacggtgcgg ctgttccccg cccacgtgcg ccgcgccgcg gagctgcgcg
    15301 acggcggctg cgtgttcgcc ggctgttcgg cgccgacctg gtggtgcgac gtccaccatg
    15361 tgctggcctg ggtcgacggc ggagcgaccg acctggccaa cgccgcgctg ctgtgcgagc
    15421 ggcaccacac caaggtccac cacggctccc gggtcgagcg acgacccgac gggcgatggc
    15481 gcacctggcg acccgacggc accgagatcc gcaccggccc gggccgcacc gggccacccc
    15541 tggccagcgc cgcctgaccc cgcacccacg accacacccc ggccggcagc cgaccgacgc
    15601 ccacccccgg gcacggtccg ctgccggctg ccggctgccg gcgcgcggga gggctcccga
    15661 ggacctcacc gtccgtcgag gtagcgccag gcaccgtcct cacggaggaa gcggctgacc
    15721 tcgtgctggc tgcccgtctc gccctcgtgc cggtaccagg cccggaactc caccgtgccc
    15781 tccgcggcga gcaacccgcc gtcgctggtg gcgagcacgt cgaggccggt ccagcgcacg
    15841 gtcgggtcga gctccagcga cggcgggcgc gtcgaggggt gccaggtggc gagcaggtat
    15901 gccgggtcgc ccacggcgaa ggcgctgtac cgcgagcgca tcagctgctc ggcggtcgcc
    15961 gccgtcgcgg tgccgtcgtg cagccggccg cagcactcgg cgtagggcag gccggtcccg
    16021 caggggcagc gtcgaggggc catgcccgcg agtctccgcc ggccgcgctc agcactcgac
    16081 cccgtcctcg gtggtgccca cgtgcaggca gtcgagggcg gcggcgaact cactgcgctg
    16141 cgctctcgtc agcgcccccg gctcgaaccg gacgacgatc cagccggaca ggtaggcctc
    16201 cccggcgaag cggcgggcca cggcgatggc gtcgtcccgg tccgcgaacc ggtacatcgt
    16261 gagcgtgtcc gaccggaccg cctgccggca cgggaggtcg ccgccgcaca gctcgtccgt
    16321 cgcccaccgg gcgttcggca tggcggtccg cgcccagctg tccccgggct ccacccaggc
    16381 gccgaggtcg atgtcccgac gggggtcgct ggtcacgacg aacgcggccg ccgcgaccag
    16441 cgcggcgacc acgaccccag cgactcccca cacggtccgc cggacccccc gcgtcgccat
    16501 cggcacatca tgaccgcgcc ggacgtgttc ccctgctgtg cgccggccga ccgcggaggg
    16561 agaccacgtg cgacacctgt ctgcgccgct gcgggtcggg ccggtgacgc tgcccaaccg
    16621 gctggtcttc ccggcccacc tgacgaacta cgccgtcgac ggccggttca ccgagcggca
    16681 cgccgcctac tacgcggccc gcgcggccgg cggggccggg ctggtcgtca ccgaggagct
    16741 ctcgaccgac cccgccgacc ggccctacga gaagctcgtc cacggctgcg accccgacgc
    16801 cctgcccggc atgcggctcg tcgccgacgc cgtccacgcg cacggcgtgc cggtgttcgc
    16861 ccagctcaac cacaacggcg ggcagtcgga ctcgctgcac acccgcacgc cggtcctcgc
    16921 gccgtccccg gtgcccgacc cgctgttccg cgaggtcccg cgcgaggcga gcaccgccga
    16981 cctggcccgg ctggtcgccg gctacgccga cgtcgccgcc cgctgtgccg ccgccgggtt
    17041 cgacggcgtc gaggtccagg cctcgcagtc ctcgctggtc cggcagttcc tctcccgcgc
    17101 caccaacctg cgcaccgacc gctacggcgg cccgctcgag tcccgcgccc gcttcctcgt
    17161 cgaggtgctc accgccgtcc gggaggcgct ggggcccggc cgcgcgctcg gcgtccggct
    17221 ggccgacgag gagggccgcg acggcgggac gacgctcgcc gaggcggtgg ccaccgcgag
    17281 gctgctcgtc gagcgcgggc tcgtcgactc cgtcagcacc accgtgggcg tcgcgacggc
    17341 gaccctcgac cgcgtcgtcc cgccgatgac caccccgccc ggctacgccc gctacctctc
    17401 cgcggcgatc cgggccgccg tcgacgtccc ggtgatcggc gtcggccgct tcctcacccc
    17461 cgcgcaggcc gagcgcgcgc tggcgatgag cgactgcgac ctggtcggcg ccgtccgcgc
    17521 gcagatcgcc gaccccgagt tcgccgccaa ggcgctgacc gggcgcgacg gcgaggtccg
    17581 ccgctgcctg ggctgcaacc aggagtgcgt cggccgcgtg ggcctgaacc ggccgctggg
    17641 ctgcgtgacc aacccgcgcg ccggccgcga ggcgccgctg ccggcaccgg agcgccgccg
    17701 ccgggtgctc gtcgtcggcg gcggaccggc agggctccgc gccgccgcca ccgccgccgc
    17761 ccgcggccac gcggtcaccg tctgggagca ggcgaccgac accggcggcg cgatccgggt
    17821 cgcggcgtcc gccccgggcc gcgaggggct gcgcccgctg gtcgacgacc tcgccgccga
    17881 gtgcgcccgg acgggggtgg cggtgcgcac cggcgtgcgc gccaccgtcg aggcggtgcg
    17941 ggcggaggcg ccggacgtcg tcgtcctcgc caccggcgcc cgcccgctgc ggccggactg
    18001 ggcgggggac ggcgaccggg tggtcgacgt ccgggacgtg ctcaccggcg cggccgaccc
    18061 ggccggcgcc gtcctggtgg tcgacgacct cggcgccgcc gcggcgacct cggtcgccga
    18121 gctgctcgcc gcgcgcggct gcacggtcga ggtggtgacg gcggcgctgg tcgtcggcca
    18181 ggacctcggc ctcaccctcg accggcccgg gtgggagcgg cgggccgcgg ctctcggcat
    18241 ccggcggacg acggagcggc tggtcaccgc cgtcgacggc cgcgccgtgc ggctgctgca
    18301 ccacccgacc ggcgcggtcg aggagcgcac cgtcgactgg ctggtcgtcg ccaccgcgcc
    18361 gcgggcggac gacgggctgt ggcacgcgct gcgcgacagc ggcctggagg tgcaccgggt
    18421 cggcgactgc ctcgccccgc gcagggccgg cgcggccacc ctggacgggg accgggtggg
    18481 ccgggcggtc tgactaccgt ggcaccggtg accgacgccg tcccgagaac gaggctcgcc
    18541 ggcgccacct ggcccgacct gcccgagcgc ccgctgctgc tggtgccgct cggcgccgtc
    18601 gagcagcacg gccaccacct gccgctggcc accgacacca cggtcgcctg cgcggtcgcc
    18661 gaggccgccg tcgacgacct ggacggcgcc ctgctcgccc ccgcactggc ctacggcgcc
    18721 agcggcgagc acgaggactt ccccggcacc gtctcgatcg gcaccgaggc gctgaccggg
    18781 ctgctcgtcg agtacggccg ctcggcgtgc cgctgggtcg ggcggctggt gctggtcaac
    18841 ggccacggcg gcaacctcga cgcgctgcgc acggccggcg cgcagctgcg ggccgagggc
    18901 cgcgaggtcg cctggttccc gtgcggcgct gccggcgccg acgcgcacgc cgggcgcacc
    18961 gagacctcac tgatgttgca cgtggaacca gaggaggtcc gcgaggaccg ggcggtggcg
    19021 ggggagaccg caccgatcga cgagctgctg ccccggctgc gcgccgaggg ggtgcgcgcg
    19081 gtcagcccga ccggggtgct cggcgacccc gccggggcgt cggcggagga gggcgcggag
    19141 ctgctcgccg ggatggccgg gcggctgacc gccgccgtcc gggcgtggga cgtcgacccc
    19201 gccggccggc tgcgcggctg acggaaccgc gccgaccacc ccgggctatc gtccgacgca
    19261 tggggtcccc gtccggttgg ctggtcgtcg tcgactacca ggaggtcttc cgcgatccga
    19321 cctccccgtg gacgacgccg cgcttcgacg agatccggcc gcgcctccgc tcgctggtcg
    19381 aggccttcgg cgaccgcgtc gtcttcaccc gcttcgtcgt cccggacgag ccgaccggtg
    19441 cgtgggccga ctactacgcc aagtacgact acttcacgca ggaccacgcc atcccgctgt
    19501 tccagctctc cgaggacccg ggcgaccgcc ccgtcgtcga cgcgccgacc ttcggcaagt
    19561 gggtccccgc cgtcgccgag ctggtcggcg acggcccggt cgtcgtcgcc ggggtggcca
    19621 ccgactgctg cgtgctctcc accgtgctgc ccgcggcgga cgccggtgtg ctggtccggg
    19681 tggtctccga cgcctgcgcc ggcgcggacg acgaggcgca cgacgacacc atgcggatcc
    19741 tcggctgcta cgccccgctg gtcgaggtca ccacgaccgc cgaggtcctg gccggggcat
    19801 gagcgggggg ctcgcggtcg ccgcaccccc gcccgaccgg ctccccgacg gcaccgccgt
    19861 ccgcctcgat gcccgcgtcc gctcccggga cggggggacg acgctgctcg gcggctcccc
    19921 gctgcggctg ctgcgcctgc acccccgcgc ccgtgacctg ctgcgcaccg accggctcgt
    19981 cgtccgggac gcgaccaccg ccgccctcgc cgcccggctg ctcgacgccg gtctcgccca
    20041 ccccgagccg gacggcgacc cggtggggga gctgaccgtc gtcgtcccgg tcaaggaccg
    20101 cccggccgag ctggcacggc tgctcaccgc gctgcgcgcc gaccccgaca ccgccgccgt
    20161 cccggtgctc gtggtggacg acggctccgc cgacccggcc gcggtgaccg ccgtggccgg
    20221 ccggcacggc gcccgggtgc tgcggcacgc caccgcccgc ggcccggccg ccgcccgcaa
    20281 cgccggcctg cgcgcggcga gcaccccgct cgtggcgttc ctcgactccg actgcgtgcc
    20341 gctggcgggc tggtccgggc cgctggtgcg gcttcccgcc gacccgcggc tggcgctggt
    20401 ggcgccccgg atcaccgcgc tcccgtcgga cggcggcggc tgggtggcgc cgtacgaggc
    20461 cacggtcagc gcgctggaca tggggcccga cccggcgccg gtcgccccgg ggacggcggt
    20521 gtcctacctg cccagcgccg cgatggtggc ccgccgggac gccctcggcg acggcttcga
    20581 cgagtcgatg cgggtcgccg aggacgtcga cctggtgtgg cggctggtcg cggccggctg
    20641 gcgggtgcgc tacgagccgt cggccgccgt cgcccacgag caccgggcgg cgaccgggga
    20701 gtggctgcgc cgccgcgcct tctacggcac cggcgccgcg ctgctggccg cgcggcacgg
    20761 ggccgccgtc gctcccgtcg tgctctcgcc gtggtcggcg gcggcctggg cgctggcgct
    20821 gaccggacgc cgctccggcg cgctgggctg cgccgcggtg ctggccgtcg ccaccgcccg
    20881 cctggcgccc cggctggccc ggcccgggca gcgcgcaccg gtcgggctgg cggcggtgct
    20941 cgtcgtgcgg ggcagcgccg cggcgggcag gacgctggcg cgcagcgtca cccgccacca
    21001 ctggccgctg gccctggtcg cggctgcggt ctcccgccgg gcccgccgtc tcgccgcggc
    21061 ggccgccgtc gccgacgccg tcctcgcctg gtggccgcac cggcgccggg tcggtctgct
    21121 gcgcttcgcc gccggccggc gcctcgagga cctcgcctac ggcgccggtc tgtgggccgg
    21181 cgcgctgcgg gcgggggacc cgcgggcgct gctgcccgcc cggcctgcac cgatacctcc
    21241 tccgaaccgg ttgggcacca ccggttccct ggtggaatcg cgtgggagcg gtcacgatgg
    21301 gcggacgatg gacccgagcc cgcggacgac gccgtgacga cgatgaaccc gtgggtcgcg
    21361 ctgcccgacg gccggcccga ccccgcgcac acccggcggc tgcgcgccgc gcacgaggca
    21421 ctcgtcacca gctccggccc cgccgcgccg gacctggtgc gcgccgtcgt ctgggactcc
    21481 tggcagcgca gtctcgccgg cggcgtcgac cccgacggcg ccgccccgcc ggtcgacctg
    21541 ctcgacgacg agctgctggc ctaccgcgcc gcccacccgc tggcgccggc gctgccggtg
    21601 atccgtaggc tgctggtcga ggacg
//
