LOCUS       NZ_FNHE01000007        24202 bp    DNA     linear   CON 03-MAY-2024
DEFINITION  Geodermatophilus siccatus strain DSM 45419, whole genome shotgun
            sequence.
ACCESSION   NZ_FNHE01000007
VERSION     NZ_FNHE01000007.1
KEYWORDS    WGS; RefSeq.
SOURCE      Geodermatophilus siccatus
  ORGANISM  Geodermatophilus siccatus
            Bacteria; Actinomycetota; Actinomycetes; Geodermatophilales;
            Geodermatophilaceae; Geodermatophilus.
REFERENCE   1
  AUTHORS   Varghese,N. and Submissions,S.
  TITLE     Direct Submission
  JOURNAL   Submitted (17-OCT-2016) DOE - JOINT GENOME INSTITUTE, LBNL, 2800
            Mitchell Drive, Walnut Creek, CA 94598, 94598, USA
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_900103785.1-RS_2024_05_03
            Annotation Date                   :: 05/03/2024 01:00:42
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 4,951
            CDSs (total)                      :: 4,891
            Genes (coding)                    :: 4,846
            CDSs (with protein)               :: 4,846
            Genes (RNA)                       :: 60
            rRNAs                             :: 2, 4, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 2, 1 (5S, 16S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 48
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 45
            CDSs (without protein)            :: 45
            Pseudo Genes (ambiguous residues) :: 0 of 45
            Pseudo Genes (frameshifted)       :: 11 of 45
            Pseudo Genes (incomplete)         :: 37 of 45
            Pseudo Genes (internal stop)      :: 5 of 45
            Pseudo Genes (multiple problems)  :: 8 of 45
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 16:54:22
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 68771
            Orig. end                         :: 92973
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            FNHE01000007.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..24202
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="1"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..24202
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..24202
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:14202]"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..14202
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     misc_feature    280..294
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.92"
                     /tool="antismash"
     misc_feature    421..441
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 18.35"
                     /tool="antismash"
     misc_feature    complement(667..681)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.83"
                     /tool="antismash"
     misc_feature    1284..1294
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 18.59"
                     /tool="antismash"
     gene            complement(1630..2286)
                     /locus_tag="BLS21_RS14090"
                     /old_locus_tag="SAMN05660642_02855"
     CDS             complement(1630..2286)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0016780 - phosphotransferase activity, for
                     other substituted phosphate groups [Evidence IEA]"
                     /GO_process="GO:0008654 - phospholipid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012949330.1"
                     /locus_tag="BLS21_RS14090"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05660642_02855"
                     /product="CDP-alcohol phosphatidyltransferase family
                     protein"
                     /protein_id="WP_091219377.1"
                     /transl_table=11
                     /translation="MLSREEYLAAWSTWHGGADPAASRLVHGWLSGVYALARRVAGLPP
                     VAVTAAGLLVAVAAVVPAAVGGPWPVLAGVLVGFSAVLDGLDGALAIATGRASRRGFVL
                     DSAVDRLSEGAFAAALWVAGAPGWLAAAFGGLCWLPDYLRARAGQAGVTETGELSVWER
                     PTRVAMTGFTLGGAGVVAGLGWSAAVVTCGTAAGCLLGVVGVAQLGTALRRALAD"
     gene            2344..3153
                     /locus_tag="BLS21_RS14095"
                     /old_locus_tag="SAMN05660642_02856"
     CDS             2344..3153
                     /NRPS_PKS="Domain: Abhydrolase_1 (51-159). E-value:
                     4.5e-13. Score: 41.3. Matches aSDomain:
                     nrpspksdomains_BLS21_RS14095_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012949331.1"
                     /locus_tag="BLS21_RS14095"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05660642_02856"
                     /product="alpha/beta fold hydrolase"
                     /protein_id="WP_091219379.1"
                     /sec_met_domain="PF00561 (E-value: 1.7e-10, bitscore: 35.0,
                     seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLAGLSPARRRLVVTVLALAVVAVLVTGAALLLGRPSGAAGREPV
                     SQDAPGPVLLVPGYGGSTAALQPLADRLTAEGRDATVVDVPGAGTGDLGAAADALGEAA
                     DAALERTGAESVDVVGYSAGGVTARLWVADGGAAVARRIVTLGSPHHGTTLADLAGRVA
                     PEECPEACRQLTTASPLLAGLNAGDETPEGPAWISIWTAQDETVTPPESARLEGALELP
                     VQSVCPGARVGHGDLPRHPLVQAMVLEELGAAPPAALGPDDCARLGG"
     aSDomain        2497..2820
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_BLS21_RS14095_Abhydrolase_1.1"
                     /evalue="4.50E-13"
                     /label="BLS21_RS14095_Abhydrolase_1.1"
                     /locus_tag="BLS21_RS14095"
                     /protein_end="159"
                     /protein_start="51"
                     /score="41.3"
                     /tool="antismash"
                     /translation="PVLLVPGYGGSTAALQPLADRLTAEGRDATVVDVPGAGTGDLGAA
                     ADALGEAADAALERTGAESVDVVGYSAGGVTARLWVADGGAAVARRIVTLGSPHHGTTL
                     ADLA"
     gene            complement(3170..3982)
                     /locus_tag="BLS21_RS14100"
                     /old_locus_tag="SAMN05660642_02857"
     CDS             complement(3170..3982)
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012949334.1"
                     /locus_tag="BLS21_RS14100"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05660642_02857"
                     /product="ABC transporter permease subunit"
                     /protein_id="WP_091219382.1"
                     /transl_table=11
                     /translation="MIGVELRKLFRRPRTWVTIAVLNALPVLVAVLVQLTDLAPRPGEG
                     PPFLSAVLTNGALFPLAALAIVLPLFLPIAVAVVAGDAVAGEAQAGTLRYLLVRPAGRT
                     RLLVAKLVAVIAFVLVTVLVVAGVGYVVGTTLFDAQPVGGGTSVSGTSLSQQELAGRSL
                     MAIGYVTVSMLGVAAFGLFFSTLTDSPLAAALGALAVLVTSSLLFTLDAASPIAPYLPT
                     RYWLAFVDLFRDPILWRDVVRGLALQGVYVGVLLAAAWANFTTKDVTS"
     gene            complement(3979..4899)
                     /locus_tag="BLS21_RS14105"
                     /old_locus_tag="SAMN05660642_02858"
     CDS             complement(3979..4899)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012949335.1"
                     /locus_tag="BLS21_RS14105"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05660642_02858"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_091219385.1"
                     /transl_table=11
                     /translation="MSAVIRTRGLVKRYGRLRAVDGIDLDVRAGDVYGFLGANGSGKTT
                     TVRMLLGLVLPTAGEVELLGERMPRAGRRVLPRVGALVEGPAHHGHLSGRANLALIDAA
                     GPGGSRRTRRARIEEVLQQVGLGGIDRRPVRAYSLGMRQRLGLAAALLRRPELLVLDEP
                     TNGLDPQGIHEIRDLLLELHRGGTTVFLSSHLLAEVEQLCTRVGVLDRGRLVLQDELAR
                     LTAPTGATVVDTPAADRVRAVLDGRVLGVEGSRVVVRGADPAEVNALLVAAGVPVTGLA
                     LQRPTLEEVVLAAAGTSADRVEAAR"
     gene            complement(4896..6002)
                     /locus_tag="BLS21_RS14110"
                     /old_locus_tag="SAMN05660642_02859"
     CDS             complement(4896..6002)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012949336.1"
                     /locus_tag="BLS21_RS14110"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05660642_02859"
                     /product="transcriptional regulator"
                     /protein_id="WP_091219387.1"
                     /transl_table=11
                     /translation="MAARGRGALARWAAVGLLVAALVALPSVVAALPADDVDVPAAELR
                     AAVLASAGVGFSGYAVSAGGLALPVSERLTDVADLFSDRTLVRVWWRGPEDHRVDVVTA
                     AGETGVHRDPGGTWTWDFEAGTATRGAPASLALPTPPDLLPAALGRRLLSEATDDELSR
                     IGARRVAGRDAVGLRLVPAEPAASVGRVDVWVDPASGLPLQVQVFAEGADLAALDTRFL
                     DLDLAVPPADVVAFTPPPEATLLTAPDTEGLIAQAEERAPDVRLPGELAGLPRRTSAGV
                     PDAVGVYGRGVTLLAAAPVPGRLAGGLREALTASPDAVTDALGTRVAAGPLGLMLVTPP
                     DGPAYVLTGTVTLDALADAARRLPGAAS"
     gene            complement(6106..7050)
                     /locus_tag="BLS21_RS14115"
                     /old_locus_tag="SAMN05660642_02860"
     CDS             complement(6106..7050)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012949337.1"
                     /locus_tag="BLS21_RS14115"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05660642_02860"
                     /product="DUF808 domain-containing protein"
                     /protein_id="WP_091219390.1"
                     /transl_table=11
                     /translation="MAGGLVALLDDVATLARAAAASVDDIGAAAGRASAKAAGVVVDDT
                     AVTPQYVHGLAAEREIPIIKRIAMGSLRNKLLILLPAVLLLSQFLPWLLTPILMIGGAY
                     LCYEGAEKVWHKLRGGHGDHAAGEETLPDEDTIVSGAVRTDFILSAEIMVISLNEVVDE
                     GFWSRAVILAVVAVGITVLVYGVVGLIVKMDDVGLSLSRRPGKAVSRLGHGMVKAMPRL
                     LAVITVVGTAAMLWVGGHILLVGSDELGLHAVYGAVHHLEEAAHEATGALGGVVGWLVN
                     TLASALVGLVVGALIVLVMNLTVHRRRTHTGSH"
     gene            7264..8004
                     /locus_tag="BLS21_RS14120"
                     /old_locus_tag="SAMN05660642_02861"
     CDS             7264..8004
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014741491.1"
                     /locus_tag="BLS21_RS14120"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05660642_02861"
                     /product="hypothetical protein"
                     /protein_id="WP_139177120.1"
                     /transl_table=11
                     /translation="MGTADDEGAALWPDRYLTEGRLVVVRSPRREPSSRWARLRAAAVR
                     LDRAARARLGLPSPDPEPPSPAPEAAFAAWDTTEARVAAAAGRAWAETVREPSWSSPLL
                     AASRFDGQAEVDRIVDLALRIRSARVSLGVRPAGTAAEYWDRQSAALEAAALRLGHRAD
                     ALIRYRDQAALLSAELRQLADLERLERSAAEVDGITAATSALPGRGDGDLRAVADEIAA
                     VRSAVTELVGLMTRTRAPLAEPPG"
     gene            8278..8925
                     /locus_tag="BLS21_RS14125"
                     /old_locus_tag="SAMN05660642_02862"
     CDS             8278..8925
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014375947.1"
                     /locus_tag="BLS21_RS14125"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05660642_02862"
                     /product="hypothetical protein"
                     /protein_id="WP_091219392.1"
                     /transl_table=11
                     /translation="MAPPLSDAVVVDVLRRVDRLTTPLVRRLGRPPELPQAEREQWWAD
                     RVSRVAAGVSAVPRLAGKLADLLPLQNTIGSAVQALVVGGVAAEHGVEDEAERVSLLAH
                     VLLDRDLPAERVRPLLERAPGAYADDVLGDRDDRSAVRTLWRVARLLGRIDDTLDARPK
                     GKLRHRALANLPVVGTLGGYAAEREGLRRAAAETAALLAGRATRAPAADPAQ"
     gene            complement(8919..9821)
                     /gene="metF"
                     /locus_tag="BLS21_RS14130"
                     /old_locus_tag="SAMN05660642_02863"
     CDS             complement(8919..9821)
                     /EC_number="1.5.1.20"
                     /GO_function="GO:0004489 - methylenetetrahydrofolate
                     reductase (NAD(P)H) activity [Evidence IEA]"
                     /GO_process="GO:0009086 - methionine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="metF"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012949341.1"
                     /locus_tag="BLS21_RS14130"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05660642_02863"
                     /product="methylenetetrahydrofolate reductase [NAD(P)H]"
                     /protein_id="WP_091219915.1"
                     /transl_table=11
                     /translation="MTRTVRELLAESRPTWSFEFFPPKSPEGATQLWTALRELERLQPS
                     FVSVTYGAGGSTREGTVSVTERIATETTMTPLAHLTAVDHSVAELRHVVSRLAAAGVRN
                     LLALRGDPPGADPQAEWVAHPEGLTYAAELVELIRSMGDFSVGVAAFPERHPRSPDFET
                     DVEMFVRKCRAGADFAITQMFFRPEDYLRMRDRVAATGCEVPIIAGVMPVTNARQITRI
                     VQLSGQAFPEHLAARFAELDGDTPEARAAVRAYGVEVATELCRTLLDEGVPGIHFITMN
                     RSTATREVHANLVAVPAPH"
     gene            10001..11128
                     /locus_tag="BLS21_RS14135"
                     /old_locus_tag="SAMN05660642_02864"
     CDS             10001..11128
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012949342.1"
                     /locus_tag="BLS21_RS14135"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05660642_02864"
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_091219394.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 3.9e-43, bitscore:
                     141.6, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIAGAQQRETPVLPPAPPPAAAEIDRVRAAVWDALSDFLEVQRET
                     LAAMDPSLVPVIDEVCALADGGKRLRPLFAYWGWRGVSGEGPRESDAAVLRAVAALEFV
                     HASALVHDDVMDGALTRRGRPATHVGFASRHGDGALAGDGDAFGVGAAILVGDLALVWS
                     DELLRCSGISPTALSRARQVWDTMRTEVTAGQYLDLLRAAGGLPGVQGALTVARYKSAG
                     YTVQRPLQLGAAIAGAGERTADVYTAIGLPLGEAFQLRDDVLGVFGDPSVTGKSADDDL
                     REGKQTLLVALAEEAADDEGRRLLTEALGNPDAGPAEFDALRALFESTGARAQVEQRIA
                     ERTALARTAIAEAPLADDARAALDALAVAATTRTA"
     gene            11128..12699
                     /gene="crtI"
                     /locus_tag="BLS21_RS14140"
                     /old_locus_tag="SAMN05660642_02865"
     CDS             11128..12699
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016166 - phytoene dehydrogenase activity
                     [Evidence IEA]"
                     /GO_process="GO:0016117 - carotenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="crtI"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1222: dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014741495.1"
                     /locus_tag="BLS21_RS14140"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05660642_02865"
                     /product="phytoene desaturase family protein"
                     /protein_id="WP_091219397.1"
                     /sec_met_domain="DAO (E-value: 3.5e-16, bitscore: 53.8,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVRTVPGRTDRVVVVGAGLAGLSAALRLRGAGREVTVVERASGPG
                     GRAGRIEERGYALDTGPSVFTAPELVADTLAAVGEKLEDRLQVVPLQTTYRAQFADGSQ
                     LDVHADVDAFAAEVEALCGPAEAAALRRYLADLAELYRLQLSTFIDRNLDTPLDLLGPE
                     LVQLARRGGFGRLSRHVERHFTDDRLRRLFSFQALYAGVSPYRAIAAYAVIAQLDIGAG
                     VWHPVGGIAAVPRAMAAAAADAGVTLRHDTEVRELEVSGSRVTGVLLGDGERLPADAVV
                     VTVDRPETLVPGFRRLRRPVYSPSCVAVHVGVRSELPGQAHHTISFGAAWREVFAELTR
                     DGRLLGGGPGTRRGKIMTDPSLLVSMPSRTDRSLAPEGGQVLSIVAPTPNLDPHSGGNP
                     DLDWTTLGPRYRDEVLGVLEERGWTGLTGAIEVEHVDTPLTWAAQGMAAGTPFALAHTF
                     GQTGPFRTPTLPRRGPENVVLAGSSVQPGVGVPMVVISGRLAAERITGRVRPSPRNWPD
                     PGTGSR"
     gene            12696..13649
                     /locus_tag="BLS21_RS14145"
                     /old_locus_tag="SAMN05660642_02866"
     CDS             12696..13649
                     /EC_number="2.5.1.-"
                     /GO_function="GO:0004659 - prenyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_phytoene_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: phytoene_synt"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012949344.1"
                     /locus_tag="BLS21_RS14145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05660642_02866"
                     /product="phytoene/squalene synthase family protein"
                     /protein_id="WP_217636132.1"
                     /sec_met_domain="phytoene_synt (E-value: 2.4e-95, bitscore:
                     312.9, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PT_phytoene_like (E-value: 4.6e-65,
                     bitscore: 213.8, seeds: 61, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTLTDPPRTQAERQAHLDAAYRHCAAINAEHGKSYHLATRLLTPD
                     RRPAVHALYAAARTADDLVDHPGADPAGDLAEWSRAVLAELEAGWSDDPVRLALVHTYR
                     RYDIAVEHLVDFLAAMTSDLDVTGYADMDALDRYMWGSASVIGLQVLPVLGTARGVARE
                     EAAPHAIALGEAFQLTNFLRDVAEDVDRGRVYLPADLMAAHGVTREQLAEKRYDTHFRE
                     LMREMVAIVRRRYDDAAPGTPMLAPESRDCVRAATDLYGGILTEIERADYRVLDRRVRV
                     SRPRRLAVFARRLTAAQLARVRVTMAKPNSRSSTGA"
     gene            complement(<13646..13855)
                     /locus_tag="BLS21_RS25905"
                     /pseudo=""
     CDS             complement(<13646..13855)
                     /GO_function="GO:0016872 - intramolecular lyase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: Lycopene_cycl_fung"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR03462.1"
                     /locus_tag="BLS21_RS25905"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="lycopene cyclase domain-containing protein"
                     /pseudo=""
                     /sec_met_domain="Lycopene_cycl_fung (E-value: 4.6e-12,
                     bitscore: 40.4, seeds: 37, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSYSALAVTAVLAVLGLDLAVYRTRMVTRPVFWVAYAIIVTFQLL
                     MNGVLTGLDVVTYDPDTIWGPRIAY"
     gene            complement(13852..14202)
                     /locus_tag="BLS21_RS14155"
                     /old_locus_tag="SAMN05660642_02868"
     CDS             complement(13852..14202)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: Lycopene_cycl_fung"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014375942.1"
                     /locus_tag="BLS21_RS14155"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05660642_02868"
                     /product="lycopene cyclase domain-containing protein"
                     /protein_id="WP_091219403.1"
                     /sec_met_domain="Lycopene_cycl_fung (E-value: 2.8e-21,
                     bitscore: 69.9, seeds: 37, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGQLTYLALLAGCLVVTAPLELLLRVRVYARWRRLLVAVAPEFAV
                     FVVWVLYAIAQGHWDYSDRLTLGVRLPGGIPVEEVLFFLVVPLCSVLALEAVRKVTGWD
                     AGYPAEEAGTGR"
     gene            complement(14213..14536)
                     /locus_tag="BLS21_RS14160"
                     /old_locus_tag="SAMN05660642_02869"
     CDS             complement(14213..14536)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012949347.1"
                     /locus_tag="BLS21_RS14160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05660642_02869"
                     /product="Rv2175c family DNA-binding protein"
                     /protein_id="WP_091219408.1"
                     /transl_table=11
                     /translation="METLTPAEVAAVLGVSPNRVRQLLREHKLMAVPGSGNSRIPADFL
                     QDGAVLKHLPGLITVLKDGGFSDAEVFEWLFRADDTLPGTPVEALRSDRHTEVTRRAQA
                     LAF"
     regulatory      14615..14699
                     /bound_moiety="5-aminoimidazole-4-carboxamide
                     ribonucleotide (ZMP)/
                     5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranosyl
                     5'-triphosphate (ZMT)"
                     /db_xref="RFAM:RF01750"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:14.4:RF01750"
                     /inference="COORDINATES: profile:INFERNAL:1.1.5"
                     /note="ZMP/ZTP riboswitches appear to regulate genes
                     involved in one-carbon metabolism; Derived by automated
                     computational analysis using gene prediction method:
                     cmsearch."
                     /regulatory_class="riboswitch"
     gene            14727..16208
                     /locus_tag="BLS21_RS14165"
                     /old_locus_tag="SAMN05660642_02871"
     CDS             14727..16208
                     /EC_number="2.1.2.1"
                     /GO_function="GO:0004372 - glycine hydroxymethyltransferase
                     activity [Evidence IEA]"
                     /GO_process="GO:0019264 - glycine biosynthetic process from
                     serine [Evidence IEA]"
                     /GO_process="GO:0035999 - tetrahydrofolate interconversion
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: Aminotran_1_2 (241-404). E-value:
                     1.3e-07. Score: 23.0. Matches aSDomain:
                     nrpspksdomains_BLS21_RS14165_Aminotran_1_2.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_1_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012949348.1"
                     /locus_tag="BLS21_RS14165"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05660642_02871"
                     /product="glycine hydroxymethyltransferase"
                     /protein_id="WP_091219411.1"
                     /sec_met_domain="Aminotran_1_2 (E-value: 6e-07, bitscore:
                     23.0, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTDVSTHATAPSDAALPHADVASAAYRSALQVIGAVEPRVADAIG
                     AELADQRASLKLIASENYASPAVLLTMGNWLSDKYAEGTVGHRFYAGCQNVDTVEALAA
                     EHARELFGAPHAYVQPHSGIDANLVAFWAVLASRVESPALEKAGVRHVNELTDADWSAL
                     RHQLGDQRMLGMSLDAGGHLTHGFRPNISGKMFEQSSYGTDPESGLLDYDAVRERAREF
                     RPLILMAGYSAYPRRVDFARMREIADEVGATLVVDMAHFAGLVAGKVFTGDFDPVPHAH
                     VVTTTTHKSLRGPRGGMVLAQPEYADAVDRGCPMVLGGPLPHVMAAKAVAFAEARQPAF
                     AGYAQRIVDNAVSLAEGLTRRGARLVTGGTDNHLVLVDVSGFGLTGRQAESALLDAGIV
                     TNRNAVPADPNGAWYTSGIRLGTPALTTRGFGADEFDRTAELIVDVLSNTTPTATRDGA
                     PSKARYATADGLADRTRDAAAELLDRHPLYPGLEL"
     aSDomain        15450..15938
                     /aSDomain="Aminotran_1_2"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_BLS21_RS14165_Aminotran_1_2.1"
                     /evalue="1.30E-07"
                     /label="BLS21_RS14165_Aminotran_1_2.1"
                     /locus_tag="BLS21_RS14165"
                     /protein_end="404"
                     /protein_start="241"
                     /score="23.0"
                     /tool="antismash"
                     /translation="RMREIADEVGATLVVDMAHFAGLVAGKVFTGDFDPVPHAHVVTTT
                     THKSLRGPRGGMVLAQPEYADAVDRGCPMVLGGPLPHVMAAKAVAFAEARQPAFAGYAQ
                     RIVDNAVSLAEGLTRRGARLVTGGTDNHLVLVDVSGFGLTGRQAESALLDAGIVTNRNA
                     "
     gene            16540..18534
                     /gene="pknB"
                     /locus_tag="BLS21_RS14170"
                     /old_locus_tag="SAMN05660642_02872"
     CDS             16540..18534
                     /GO_function="GO:0004672 - protein kinase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="pknB"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014375938.1"
                     /locus_tag="BLS21_RS14170"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05660642_02872"
                     /product="Stk1 family PASTA domain-containing Ser/Thr
                     kinase"
                     /protein_id="WP_175479571.1"
                     /sec_met_domain="Pkinase (E-value: 1.7e-51, bitscore:
                     169.1, seeds: 54, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDTAVTDPVVGLVLEGRYLLEERLARGGMSTVYAATDLRLHRTVA
                     VKVMAEHLAHDPTFVDRFTREARAAAMLSHPNVVSVSDQGSDQGLVFLVMELVRGRTLR
                     DLLQARGRLTVAEAFAVLEPVLSGLTAAHRAGIVHRDIKPENVLIGADGVVKVADFGLA
                     RALTGTGQTSHTGGVLIGTVAYLSPEQLERGKADARSDVYAAGVVLYEMLTGHPPYGGD
                     TPLAVAYQHVHHDMPRPSEEVPGLPWEVDELVARTTRREPAIRPLDAGAFLADLEDVRT
                     DLAIERVPVPTGRVPATADTLRPTNRPSRPTRHTGDPAAPRTEVLGPGGTRPGRASGRT
                     SMLPGAGTGTDPGARRPAPQRARPGVPPHIRRRRARLAVALVLLTAITIGAVGWWLGSG
                     RWTTVPQLAGKEQAAAIDLLQEAGLTPDCCEERFSEDVADGVVISAEPEGGEAIRGTDV
                     RLVVSKGPERFEASPDLVGQPLDAVRTALEKVPVVVQEVQDYDNEVPVGHVTGFDPEAG
                     TELKRDQELVVYVSRGHEPVTVPAVVGLSPDEATANLETLGFAVERTEGRSADVDPGEV
                     MAVTPASGQQAPYRSTVTLQVSAGLPQVQVPDVVGRSQQEAAALLQQAGLQVQVSQFFG
                     DRVIRQSPAAGQTVDIGTQVTILVTFERD"
     gene            18558..19460
                     /locus_tag="BLS21_RS14175"
                     /old_locus_tag="SAMN05660642_02873"
     CDS             18558..19460
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014375937.1"
                     /locus_tag="BLS21_RS14175"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05660642_02873"
                     /product="deoxyribonuclease IV"
                     /protein_id="WP_091219414.1"
                     /transl_table=11
                     /translation="MPPIGAHIQIKGGLAKGGLAYTDAVGARAVQVFVGNPRGWKLTAG
                     DPRQDALFTAGCAERGVPSFIHTPFLVNVGSPTEATVEQSIATIAHNLARGVQLGCQGV
                     VVHAGSAVGEDRYEDALRQLHERLLPVLEAAPDDGPRLLVEPTAGGGRSLAATVEDLGP
                     YFAALEHHPLLGVCFDTCHAWAAGHELTAPGGTAATLDALEAAVGPGRLGLVHANDSLD
                     ECGSKRDRHTTIGAGTIGVAPFAELLAHPSMAGVPVVVETPSERDGVASAGHAADIALL
                     NELAVLRTAPRPGAVPLAS"
     gene            19662..20840
                     /locus_tag="BLS21_RS14180"
                     /old_locus_tag="SAMN05660642_02874"
     CDS             19662..20840
                     /EC_number="3.4.-.-"
                     /GO_function="GO:0008236 - serine-type peptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S8"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1075: alkaline serine protease, subtilase family"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012311.4"
                     /locus_tag="BLS21_RS14180"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05660642_02874"
                     /product="S8 family peptidase"
                     /protein_id="WP_091219417.1"
                     /sec_met_domain="Peptidase_S8 (E-value: 6e-37, bitscore:
                     121.5, seeds: 43, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPTRRTLAAGLVAALATAGLGATAAPAAAAPSDGPRATYVVTVDR
                     STLPVQAAERARGLGGQVDHVYTTALAGFAVTLPEAAASRLSAIPGVVAVERDQAVTTD
                     ESQSGATWGLDRTDQRDLPLDTTYGWTTTGAGVTAYVIDTGIAAGHTEFTGRVGAGFDA
                     VDGGAPDDCNGHGTHVAGTVGGTTYGVAKGVRLVGVRVLGCDGSGTTAGVVAGIDWVTA
                     DHQAGAPAVANMSLGGGTSTAIDAAVRNSIADGVSYAVAAGNGSSAGVAQDACASSPAR
                     VPNALTVGATDRTDQAASFSNYGSCVDLFAPGVGITSAWYTGSTATNTISGTSMATPHV
                     AGVAALVLSTTPSAPPATVAATVTAAATPGHVVLSRTATRAGTPNRLLYSSY"
     gene            complement(20946..21956)
                     /locus_tag="BLS21_RS14185"
                     /old_locus_tag="SAMN05660642_02875"
     CDS             complement(20946..21956)
                     /NRPS_PKS="Domain: Beta_elim_lyase (5-271). E-value:
                     8.4e-88. Score: 286.3. Matches aSDomain:
                     nrpspksdomains_BLS21_RS14185_Beta_elim_lyase.1"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014375935.1"
                     /locus_tag="BLS21_RS14185"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05660642_02875"
                     /product="GntG family PLP-dependent aldolase"
                     /protein_id="WP_217636133.1"
                     /transl_table=11
                     /translation="MADVVDLRSDTVTKPTPGMRRAMAEAEVGDDVYGEDPAINALEER
                     VAGMFGHEAGLFVPSGTMGNQIGLRLVCEPGQEVLCDAEAHIVTYEMGAAAVLFGISTR
                     TVVSDGGRLDTAQLVEQVRPRDNWHLTATAAIAVENTHNRGGGLVQPLEQLQALWDWSR
                     QAGVDVHLDGARIWNASVASGVDLATYGGLADTASVCLSKGLGAPVGSVLVASAERIAA
                     ARLWRKRLGGGMRQAGVLAAAGLYALDAHLDRLAEDHEHAQLLAKRLGVDPATVQTNIV
                     RLDDVPAPVVAEAAKAQGVLVSQVSDRRLRLVTNLGVDRAAVERAGDVLAGILDR"
     aSDomain        complement(21144..21941)
                     /aSDomain="Beta_elim_lyase"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_BLS21_RS14185_Beta_elim_lyase.1"
                     /evalue="8.40E-88"
                     /label="BLS21_RS14185_Beta_elim_lyase.1"
                     /locus_tag="BLS21_RS14185"
                     /protein_end="271"
                     /protein_start="5"
                     /score="286.3"
                     /tool="antismash"
                     /translation="DLRSDTVTKPTPGMRRAMAEAEVGDDVYGEDPAINALEERVAGMF
                     GHEAGLFVPSGTMGNQIGLRLVCEPGQEVLCDAEAHIVTYEMGAAAVLFGISTRTVVSD
                     GGRLDTAQLVEQVRPRDNWHLTATAAIAVENTHNRGGGLVQPLEQLQALWDWSRQAGVD
                     VHLDGARIWNASVASGVDLATYGGLADTASVCLSKGLGAPVGSVLVASAERIAAARLWR
                     KRLGGGMRQAGVLAAAGLYALDAHLDRLAEDHEHAQLLAKRLGV"
     gene            complement(21949..23286)
                     /locus_tag="BLS21_RS14190"
                     /old_locus_tag="SAMN05660642_02876"
     CDS             complement(21949..23286)
                     /EC_number="2.5.1.54"
                     /GO_function="GO:0003849 - 3-deoxy-7-phosphoheptulonate
                     synthase activity [Evidence IEA]"
                     /GO_process="GO:0009423 - chorismate biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012949352.1"
                     /locus_tag="BLS21_RS14190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05660642_02876"
                     /product="3-deoxy-7-phosphoheptulonate synthase class II"
                     /protein_id="WP_091219420.1"
                     /transl_table=11
                     /translation="MTLSDPAALLPDLDRWRELPAAQQPEWPDRAALDTVLATLSSVPP
                     IVAPSEVDELRTRLAEVAQGRAFLLQGGDCAETFDLNTDAHLQSTTRTLLQMAVVLTYG
                     ASVPVVKVGRVAGQYAKPRSSNTDALGLPSYRGDMVNSLEPVLEKRIPDPNRLVRAYAN
                     SAAAMNMIRAYARGGMADLHAVHDWNKDFVASSPAGVRYEVIAREIDRALAFMKACGVD
                     DTALRGVELYNSHEGLILDYERALLRVHEGRPYAASAHFVWIGERTRQLDGAHVEFMSR
                     IANPIGVKIGPTTSPEQATELVERLDPEGIPGRLTLISRMGNGKIRDVLPAIVEKVTAS
                     GHQVVWQCDPMHGNTHESSTGYKTRHFDRVVDEVLGFFDVHRALGTWPGGIHVELTGED
                     VTECLGGAMEISDEDLNSRYETACDPRLNTGQSLELAFLVAEMLRG"
     misc_feature    23492..23508
                     /note="TFBS match to NtrC, Nitrogen regulatory protein C,
                     confidence: weak, score: 21.67"
                     /tool="antismash"
     misc_feature    complement(23711..23725)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: strong, score: 19.46"
                     /tool="antismash"
     misc_feature    23846..23861
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 19.83"
                     /tool="antismash"
ORIGIN
        1 gggggatgat cgtgaccttg cggaccgggt cggcacccgg ctgcagcatg cccagcaggg
       61 cgtggccggc ctcgtggtag gcggtgcgcc ggcgctcctc gggcgggatc acgacatctc
      121 gttcggcacc cagctggatc cgctccaggg cctcgccgaa gtcgcgggcc gagaccgtgt
      181 ccgcaccgcg gcgggcggcg ccgatggccg cctggttgac caggttggcc aggtcggcgc
      241 cggtcatgcc aggggtgacg gcggcgacct ggtgcaggtc gacgtcgtcg gccagcggga
      301 cgccgcggac gtgcacctgc aggatcgcgt agcgaccgtc gaggtccggc gggttgaccg
      361 tgatggtgcg gtcgaagcgg ccgggacgca gcagggcggg gtcgaggacg tcgggccggt
      421 tggtggccgc catgacgatc acgccctcgg cgccggagaa accgtccatc tcggtgagga
      481 tctggttgag cgtctgctcc cgctcgtcgt gtccgccggt ggcgaccgcg ctgccgcggg
      541 accggccgat ggtgtcgatc tcgtcgatga agacgatcgc cggtgccacc ttgcgcgcct
      601 cggcgaacag ctcgcggacc cgctgcgccc cgacgccgac gatcagctcg atgaactccg
      661 acgcgctggc cgagaagaac ggcacgccgg cctctcccgc cgtggcgcgg gccagcagcg
      721 tcttgccggt gccgggcggc ccggcgagca ggacgccctt gggcgcccgg gcgcccagcc
      781 gccggtactt gtccgggttg cgcaggaagt ccactacctc gctgatctcg gcctcgacct
      841 cgtcgatgcc cgccacgtcg tcgaacgtga cccggacgct ctccgggtcg accggcttgc
      901 gcctgctgct cccgccgccg aacaggccgg cgccgagctg gcgctgacgc cggaacagcc
      961 accagtagaa ggcgacgagc agcaggatcg gggcgaagga gatcagcagg ttccacagcg
     1021 cgccgcgctg ctcgaccacc ggctcggcgc tgaccgtggc gccggcgtcc tcgagccggg
     1081 tgagcaggtc gtcctcggcg aaggtcgggc gctcggtggc gaactgcttg tagttctcac
     1141 ccgagctgcc ggggacgggg cgggcggccc gcagctcccc ctggatcgtc gacccccggg
     1201 cgaagacctc cgccacgttg cgcgcgtcca cctggtcgga gaactcggtg taggagacgg
     1261 ggaccggcgc gtcgccctgg tcctgccagg tcaccaggcc gaacagcagc acgtaggcga
     1321 gcagcgcgac ggcgagcggg cgcagccgcc gcaagcgcga gggccggtcc ccgtcgtcct
     1381 ggcccggcgg cacgccctcg gtgcgccagg ggcgctcggg ggcccgggtc tccggctgcg
     1441 ggctgggccg gccgcgacgg gtggcacccg agggccgggt cggtcggtcg tccatctgcg
     1501 gtctccgctg ggctcgacgg gatcactccc ctcctacccc gcccaggatg ctcagcagtc
     1561 cccgcagccg gcgtccggcc ccctgcaggg tcccgccgcg agctcgcgag cggcggggca
     1621 gggggtcctt caatcggcca gcgcccgccg cagcgccgtc cccagctggg cgacgccgac
     1681 gacgccgagc aggcagccgg ccgccgtccc gcaggtgacc accgccgcgg accagccgag
     1741 gccggccacc accccggccc cgccgagggt gaagccggtc atggcgaccc gggtggggcg
     1801 ctcccagacc gacagctccc cggtctcggt gacgccggcc tgcccggccc gggcccgcag
     1861 gtagtccggc agccagcaca gcccgccgaa cgccgcggcc agccagccgg gggcgccggc
     1921 cacccagagc gcggcggcga acgccccctc gctgagccgg tcgacggccg agtcgaggac
     1981 gaagccgcgg cgcgaggccc gcccggtcgc gatggccagc gctccgtcga gcccgtccag
     2041 gacggcggag aaccccacca gcacgccggc gagcaccggc cacgggccac cgaccgcggc
     2101 cgggacgacg gctgccaccg cgacgagcag ccccgcggcg gtgaccgcga ccggcggcag
     2161 cccggcgacc cgccgggcca gcgcgtacac gccggacagc cagccgtgca ccagccggct
     2221 ggccgccggg tcggccccgc cgtgccacgt cgaccaggcg gcgaggtact cctcgcggct
     2281 cagcacggcg cccgctccac cagcgcagtc caccaggcgc ggcggaccgg ggacagtgga
     2341 ggggtgctcg ccggtctctc ccccgcccga cgccgcctgg tcgtcaccgt cctggccctc
     2401 gcggtcgtcg ccgtcctggt caccggcgcg gcgctgctgc tggggcggcc gtcgggcgcc
     2461 gcgggccgcg agccggtgtc gcaggacgca cccggcccgg tgctgctcgt gcccggttac
     2521 ggcggctcga ccgcggcgct gcagccgctg gccgaccggc tgaccgccga gggacgcgac
     2581 gccaccgtgg tcgacgtgcc cggcgccggc accggggacc tcggcgccgc ggcggacgcg
     2641 ctcggcgagg ccgccgacgc ggccctggag cgcaccggcg ccgagagcgt ggacgtggtc
     2701 ggctactccg ccgggggcgt caccgcccgg ctgtgggtgg ccgacggcgg cgcggccgtc
     2761 gcccgccgca tcgtcacgct cggctccccg caccacggca ccacgctggc cgacctggcc
     2821 gggcgggtgg cgccggagga gtgccccgag gcctgccgcc agctgaccac cgcgagcccg
     2881 ctgctcgccg gcctcaacgc cggcgacgag acgccggagg ggccggcctg gatctcgatc
     2941 tggaccgcgc aggacgagac ggtgaccccg ccggagtccg cccggctgga gggcgcgctg
     3001 gagctgccgg tgcagtcggt ctgccccggc gcccgcgtcg gccacggcga cctgccgcgc
     3061 cacccgctgg tgcaggcgat ggtgctcgag gagctgggcg ccgcgccgcc ggccgcgctg
     3121 ggccccgacg actgcgcccg cctcggcggg tgacgaggcg gtcctgctcc tagctcgtga
     3181 cgtccttggt ggtgaagttc gcccaggccg cggccagcag cacgccgacg tacacgccct
     3241 gcagcgccag cccgcggacg acgtcccgcc acaggatcgg atcgcggaac aggtcgacga
     3301 aggccagcca gtaccgggtg ggcaggtagg gcgcgatcgg cgaggccgcg tccagggtga
     3361 acagcagcga ggaggtcacc agcaccgcca gcgcgccgag cgcggcggcc agcggcgagt
     3421 cggtcagcgt ggagaagaac agcccgaagg cggcgacgcc gagcatggag accgtcacgt
     3481 acccgatcgc catgaggctg cggccggcca gctcctgctg cgacagcgag gtgcccgaca
     3541 ccgacgtccc gccgccgacg ggctgggcgt cgaacagcgt cgtcccgacg acgtagccca
     3601 cgcccgccac caccagcacg gtgaccagca cgaacgcgat gaccgcgacc agcttggcga
     3661 cgagcagccg ggtgcgcccg gccgggcgga ccagcaggta gcgcagcgtg ccggcctgcg
     3721 cctcgccggc gacggcgtcc ccggccacga cggcgaccgc gatgggcagg aacagcggca
     3781 gcacgatggc cagcgccgcc agcgggaaca gcgcgccgtt ggtgaggacc gcggacagga
     3841 acggcgggcc ctcccccggc cgcggggcca ggtcggtcag ctgcaccagg accgcgacca
     3901 gcaccggcag cgcgttgagg acggcgatcg tcacccaggt gcgcggacgg cggaacagct
     3961 tgcgcagctc gacgccgatc accgggccgc ctccacccgg tcggcgctgg tgccggccgc
     4021 ggcgagcacg acctcctcca gggtgggccg ctgcagcgcc agcccggtca ccggcacccc
     4081 cgcggccacg agcagcgcgt tgacctcggc cgggtcggcg ccgcgcacca ccacccgcga
     4141 gccctcgacc ccgagcaccc ggccgtcgag cacggcccgc acccggtcgg cggccggggt
     4201 gtccaccacc gtcgcgccgg tgggcgcggt cagccgggcc agctcgtcct gcaggaccag
     4261 ccggccgcgg tccagcacgc cgacccgggt gcacagctgc tcgacctcgg ccagcaggtg
     4321 gctggagagg aagaccgtcg tcccgccgcg gtgcagctcc agcagcaggt cccggatctc
     4381 gtggatgccc tgcgggtcca ggccgttggt cggctcgtcg agcaccagca gctccgggcg
     4441 gcgcagcagc gcggcggcca gcccgagccg ctgccgcatg ccgagggagt aggcgcgcac
     4501 cggccggcgg tcgatgccgc cgagacccac ctgctggagc acctcctcga tgcgggcacg
     4561 gcgggtgcgc cgggagccgc ccggcccggc cgcgtcgatc agcgcgaggt tggcccggcc
     4621 ggacaggtgc ccgtggtgcg ccggcccctc gaccagggcg cccacccggg gcagcacccg
     4681 gcggccggcg cgcggcatcc gctcgcccag cagctcgacc tcgcccgcgg tcggcagcac
     4741 caggcccagc agcatccgca ccgtcgtcgt cttgcccgag ccgttggcgc cgaggaagcc
     4801 gtagacgtcg ccggcgcgga cgtcgaggtc gatgccgtcg accgcgcgca gccggccgta
     4861 gcgcttgacc agcccccggg tgcggatcac cgcgctcacg aggccgcccc gggcagccgg
     4921 cgggcggcgt cggccagtgc gtcgagggtg accgtgccgg tgagcacgta ggccgggccg
     4981 tcgggcgggg tcaccagcat cagccccagc ggacccgcgg cgacccgggt gccgagcgcg
     5041 tcggtgacgg cgtccgggct ggcggtcagc gcctcgcgca gccccccggc cagccggccc
     5101 ggcacgggcg cggccgccag cagggtcacg ccgcggccgt acacgcccac cgcgtcgggc
     5161 acccccgcgg aggtccgccg gggcaggccg gccagctctc cgggcagccg cacgtccggc
     5221 gcccgctcct cggcctgcgc gatcagcccc tcggtgtcgg gcgcggtcag cagggtggcc
     5281 tccggcggcg gggtgaaggc gacgacgtcc gccgggggga cggcgaggtc caggtcgagg
     5341 aagcgggtgt ccagcgccgc gaggtccgcg ccctcggcga acacctgcac ctgcagcggc
     5401 agcccgctgg cggggtcgac ccacacgtcg acccggccca cggacgcggc cggctcggcg
     5461 ggcaccagcc gcaggccgac ggcgtcgcgg ccggccaccc ggcgggcgcc gatgcgggag
     5521 agctcgtcgt cggtggcctc ggacagcagc cgccggccga gcgcggcggg cagcaggtcc
     5581 ggcggggtgg gcagcgcgag ggacgccggg gcgccacggg tggcggtgcc ggcctcgaag
     5641 tcccaggtcc aggtgccgcc ggggtcgcgg tgcacgccgg tctcccccgc cgcggtgacc
     5701 acgtcgaccc ggtggtcctc cgggccgcgc caccacaccc gcaccagcgt ccggtcgctg
     5761 aacaggtcgg cgacgtcggt gagccgctcg gacaccggca gggccaggcc gccggcggag
     5821 accgcgtagc cggagaagcc gacgcccgca ctggccagca ccgcggcccg gagctcggcc
     5881 gcgggcacgt ccacgtcgtc cgccgggagc gccgcgacga ccgacggcag cgccaccagc
     5941 gccgcgacga gcaggccgac ggcagcccac cgggcgagcg cgcctcgccc ccgtgccgcc
     6001 atgcacccca cggtacgagc ggacggcctg gccccgtctc gggtcccgcc cccgtccagg
     6061 ggctcaccgc gagcctgcga gtggtgagga ggacggggtc cttcctcagt gcgagccggt
     6121 gtgcgtcctg cgccggtgca ccgtgaggtt catgacgagc acgatcagcg cccccacgac
     6181 gagcccgacg agcgcgctgg ccagggtgtt gacgagccac cccaccaccc cgccgagggc
     6241 cccggtggcc tcgtgcgccg cctcctccag gtggtgcacg gccccgtaca cggcgtgcag
     6301 gcccagctcg tcactgccga ccagcaggat gtgaccgccg acccacagca tcgcggcggt
     6361 gccgaccacg gtgatgacgg cgagcagccg cggcatcgcc ttcaccatcc cgtggcccag
     6421 gcgggacacg gccttcccgg ggcgacgcga caggctcaga ccgacgtcgt ccatcttcac
     6481 gatgaggccg acgacgccgt agacgaggac cgtgatgccg accgcgacga ccgcgaggat
     6541 gaccgcccgc gaccagaagc cctcgtcgac cacctcgttc agcgagatga ccatgatctc
     6601 cgccgagagg atgaagtcgg tgcgcacggc cccggacacg atggtgtcct cgtccggcag
     6661 cgtctcctcg ccggcggcgt ggtcgccgtg cccgccgcgg agcttgtgcc acaccttctc
     6721 cgcgccctcg tagcagaggt aggcgccgcc gatcatgagg atcggggtga gcagccacgg
     6781 caggaactgg ctgagcagca gcaccgcggg cagcaggatg agcagcttgt tgcgcagcga
     6841 gcccatggcg atgcgcttga tgatcgggat ctcgcgctcg gcggccaggc cgtgcacgta
     6901 ctgcggcgtg acggcggtgt cgtcgacgac gacgccggcg gccttcgcgc tggcccggcc
     6961 ggcagcggcg ccgatgtcgt cgaccgaggc ggcggcggcg cgcgccagcg tcgccacgtc
     7021 gtcgagcagt gctacgagtc caccggccac ggaacgtcct ctcgcttggt cagcactcgc
     7081 gtgcagtctc ggtgatcgtg gtccgtccgg ccgcaccggg cgactccccg tccgggatcc
     7141 cgggcaggac tacccggctg aggacacgcc gaacgcccgg tccgcagggt ccgtcgtccg
     7201 gcggccggga ccggcacgct ggagcgacgg gctgctcacc gggtgcagca ggagggcagg
     7261 accatgggga cggcggacga cgagggcgcg gcgctgtggc ccgaccggta cctcaccgag
     7321 ggccggctgg tcgtcgtgcg ctcgccccgg cgggagccgt cgtcgcgctg ggcgcggctg
     7381 cgcgcggccg ccgtccggct ggaccgggcc gcccgcgccc ggctgggact gccgtccccc
     7441 gatcctgagc cgccgtcccc ggcacccgag gcggcgttcg cggcgtggga caccaccgag
     7501 gcgcgcgtcg ccgcggccgc cgggcgggcg tgggccgaga cggtgcgcga gccgtcctgg
     7561 tcctccccgc tgctcgcggc gagccgcttc gacggccagg ccgaggtcga ccgcatcgtc
     7621 gacctcgcgc tgcgcatccg gtcggcccgc gtctccctcg gggtgcgccc ggccgggacg
     7681 gcggcggagt actgggaccg gcagtccgcc gcgctggagg ccgccgccct ccggctcggg
     7741 caccgcgccg acgcgctgat ccgctaccgc gaccaggccg cgctcctctc ggccgagctg
     7801 cgccagcttg ccgacctgga gcggctggag cgcagcgccg cggaggtcga cgggatcacc
     7861 gccgcgacgt cggcgctgcc cggtcggggg gacggcgacc tgcgtgcggt ggccgacgag
     7921 atcgccgcgg tgcgcagcgc ggtgaccgag ctggtcgggc tgatgacccg cacccgcgcg
     7981 ccgctggccg agccgccggg ctgaggggcg aggtgggtgc tcccgcccga gcccacgagc
     8041 tgatcgacga gagccacgag gccggccggg tgctgactca ccaccacgga ctctgcgcgc
     8101 tggtggcccc ctcgacctgc gggaacgggc cacgggcgcg cagtcgtccc cgcgacgcag
     8161 ccgccacgcc gggcgaggtg cgctcgtggc accttcccgg gccgggatgt gccgcagccg
     8221 cacacacccg gccgtccgcg tgcatggccc ggcggcgagc gcgggtagag cgactccatg
     8281 gcgcctcccc tcagcgacgc ggtcgtcgtc gacgtcctcc gccgggtcga ccggctgacg
     8341 acgccgctgg tccgccggct cggccgccca ccggagctgc cgcaggccga gcgggagcag
     8401 tggtgggccg accgggtctc gcgcgtcgcg gccggcgtca gcgccgtccc ccgcctcgcc
     8461 ggcaagctgg ccgacctgct gccgctgcag aacacgatcg gctccgcggt ccaggcgctg
     8521 gtggtgggcg gggtggccgc ggagcacggc gtcgaggacg aggccgagcg ggtgtcgctg
     8581 ctggctcacg tgctgctcga ccgcgacctg cccgccgagc gggtgcggcc gctgctggag
     8641 cgggcccccg gcgcctacgc cgacgacgtc ctcggggaca gggacgaccg cagcgccgtc
     8701 cgcaccctgt ggcgggtggc ccggctgctc ggccgcatcg acgacaccct cgacgcccgg
     8761 cccaagggca agctgcggca ccgggccctg gcgaacctgc cggtggtcgg cacgctcggc
     8821 ggttacgcgg ccgagcggga gggcctgcgc cgggcggcgg ccgagacggc ggcgctgctg
     8881 gccggccgcg ccacccgggc ccccgcggcg gacccggctc agtgaggagc ggggaccgcc
     8941 accaggttgg cgtggacctc acgggtcgcc gtcgaccggt tcatggtgat gaagtggatg
     9001 cccgggacgc cctcgtcgag cagcgtccgg cacagctcgg tggcgacctc gacgccgtag
     9061 gcccgcaccg cggccctggc ctcgggggtg tccccgtcca gctcggcgaa gcgggcggcc
     9121 aggtgctcgg ggaacgcctg cccggacagc tggacgatgc gggtgatctg ccgggcgttg
     9181 gtcaccggca tgaccccggc gatgatcggc acctcgcagc cggtggcggc cacccggtcg
     9241 cgcatccgca ggtagtcctc cgggcggaag aacatctggg tgatcgcgaa gtcggcgccg
     9301 gcccggcact tgcgcacgaa catctcgacg tcggtctcga agtccggcga gcgcgggtgc
     9361 cgctccggga aggcggccac gccgacggag aagtcaccca tggagcggat cagctcgacc
     9421 agctcggcgg cgtaggtcag cccctccggg tgggccaccc actccgcctg cgggtcggcg
     9481 cccggcgggt ccccgcgcag cgccagcagg ttccgcacgc ccgccgcggc cagccggctg
     9541 accacgtgcc ggagctcggc gacgctgtgg tcgacggcgg tcaggtgggc cagcggggtc
     9601 atcgtcgtct cggtggcgat gcgctcggtg accgagacgg tgccctcgcg ggtcgacccg
     9661 ccggcgccgt aggtgaccga cacgaacgac ggctgcagcc gctcgagctc gcgcagcgcc
     9721 gtccacagct gggtggcgcc ctcggggctc ttgggcggga agaactcgaa ggaccacgtc
     9781 ggccggctct cggcgagcag ctcgcgcacg gtccgcgtca tggacagcga ggatacggac
     9841 ccgccggagt ccggcccgcc ctgcatccgt ccggcacgcc cccggagaag gtcctccggc
     9901 accgccgccc caccggcccc aggaggcaga ccccgtggcc ctgaccgact ccgcccggat
     9961 cccggccgcg cctgatcgaa tggcgcgcga tactcggtcc gtgatcgccg gggcgcagca
    10021 gcgcgagaca cccgtcctcc ccccggctcc cccgccggcc gccgccgaga tcgaccgcgt
    10081 gcgcgcggcg gtctgggacg ccctctcgga cttcctcgag gtgcagcggg agaccctcgc
    10141 ggcgatggac ccgtcgctcg tcccggtgat cgacgaggtc tgcgccctgg ccgacggcgg
    10201 caagcggctg cgcccgctgt tcgcctactg gggctggcgc ggcgtcagcg gcgaggggcc
    10261 ccgggagtcc gacgcggcgg tgctgcgggc ggtggccgcg ctggagttcg tgcacgccag
    10321 cgcgctggtg cacgacgacg tcatggacgg cgcgctgacc cgccgcggcc gcccggcgac
    10381 ccacgtcggc ttcgcctccc ggcacggcga cggcgcgctg gccggggacg gcgacgcctt
    10441 cggcgtgggc gcggcgatcc tcgtcggcga cctcgcgctg gtgtggtccg acgagctgct
    10501 gcgctgctcg ggcatctccc ccaccgcgct ctcccgggcc cgccaggtct gggacaccat
    10561 gcgcaccgag gtgaccgccg ggcagtacct ggacctgctg cgcgccgccg gcggcctgcc
    10621 cggtgtgcag ggcgcgctga ccgtggcccg ctacaagagc gccggctaca ccgtgcaacg
    10681 gccgctgcag ctgggcgccg ccatcgccgg cgccggcgag cgcaccgccg acgtctacac
    10741 cgcgatcggc ctgccgctgg gtgaggcgtt ccagctgcgc gacgacgtcc tcggggtgtt
    10801 cggcgacccg tcggtcaccg gcaagtccgc cgacgacgac ctgcgcgagg gcaagcagac
    10861 gctcctggtg gcgctggccg aggaggccgc ggacgacgag ggacggcggc tgctcaccga
    10921 ggcgctgggg aaccccgatg ccggcccggc cgagttcgac gcgctgcggg cgctcttcga
    10981 gtccaccggc gcccgcgcgc aggtcgagca gcggatcgcc gagcgcaccg ccctcgcccg
    11041 caccgccatc gccgaggccc cgctggccga cgacgcccgg gccgccctcg acgcgctcgc
    11101 cgtcgccgcg accacccgca ccgcctgatg gtccgcaccg tccccgggcg caccgaccgc
    11161 gtcgtcgtcg tgggcgccgg cctcgccggg ctgtcggcgg ccctgcggct gcgcggcgcc
    11221 ggccgggagg tcaccgtcgt cgaacgcgcc tccggccccg gcgggcgcgc cgggcggatc
    11281 gaggagcgcg gctacgccct cgacaccggc ccgtcggtgt tcaccgcccc ggagctggtc
    11341 gccgacaccc tcgccgcggt cggcgagaag ctcgaggacc ggctgcaggt ggtccccctg
    11401 cagaccacct accgggcaca gttcgccgac ggctcgcagt tggacgtgca cgccgacgtc
    11461 gacgcgttcg ccgccgaggt cgaggcgctg tgcgggcccg ccgaggcggc cgcgctgcgc
    11521 cggtacctgg ccgacctggc cgagctctac cggctgcagc tgagcacctt catcgaccgc
    11581 aacctcgaca ccccgctgga cctgctcggc cccgagctgg tgcagctggc ccggcgcggc
    11641 ggcttcggcc ggctgtcccg gcacgtcgag cggcacttca ccgacgaccg gctgcgccgg
    11701 ctgttcagct tccaggccct ctatgccggg gtctcgccgt accgcgcgat cgccgcctac
    11761 gcggtcatcg cccagctcga catcggcgcc ggcgtctggc accccgtcgg cgggatcgcc
    11821 gccgtccccc gcgcgatggc cgccgcggcc gccgacgccg gtgtgaccct gcgccacgac
    11881 accgaggtgc gggagctgga ggtcagcggg tcgcgggtca ccggcgtgct gctgggcgac
    11941 ggcgagcggc tgcccgcgga cgccgtcgtc gtcaccgtcg accggccgga gacgctggtg
    12001 cccggcttcc ggcggctgcg gcggccggtg tactcgccgt cctgcgtggc cgtgcacgtc
    12061 ggcgtccgca gcgagctccc cggccaggcg caccacacga tcagcttcgg cgccgcgtgg
    12121 cgcgaggtct tcgccgagct gacccgcgac ggccggctcc tcggcggggg tcccgggact
    12181 cggcggggga agatcatgac cgacccgagc ctgctggtca gcatgccgtc gcgcaccgac
    12241 cgcagcctcg cccccgaggg cggccaggtg ctgagcatcg tcgcgcccac cccgaacctg
    12301 gacccgcaca gcggcggcaa ccccgacctg gactggacga cgctgggccc ccgctaccgc
    12361 gacgaggtgc tgggcgtgct ggaggagcgc ggctggaccg ggctgaccgg cgcgatcgag
    12421 gtcgagcacg tcgacacccc gctgacctgg gcggcgcagg gcatggccgc ggggacgccg
    12481 ttcgcgctgg cgcacacctt cggccagacc ggcccgttcc ggacaccgac gctgccccgc
    12541 cgcggcccgg agaacgtggt cctcgccggc tcgtcggtgc agcccggcgt cggcgtgccc
    12601 atggtcgtca tcagcggccg gttggccgca gagaggatca ccggacgggt ccggccatcc
    12661 ccgcggaact ggccggaccc gggaacgggc agccgatgac cctcaccgac ccgccgcgca
    12721 cgcaggccga gcggcaggcc cacctcgacg ccgcctaccg gcactgcgcg gcgatcaacg
    12781 ccgagcacgg caagagctac cacctggcca cccggctgct caccccggac cggcgcccgg
    12841 cggtccacgc gctctacgcc gccgcccgca ccgcggacga cctcgtcgac caccccggcg
    12901 ccgacccggc cggcgacctc gccgagtggt cccgcgcggt gctggccgag ctggaggccg
    12961 gctggtccga cgacccggtg cgcctcgccc tggtgcacac ctaccgccgg tacgacatcg
    13021 ccgtcgagca cctggtcgac ttcctcgccg cgatgaccag cgacctcgac gtcaccgggt
    13081 acgccgacat ggacgccctc gaccggtaca tgtggggctc ggcgtcggtc atcggcctgc
    13141 aggtgctgcc cgtgctcggc accgcccggg gcgtggcccg cgaggaggcc gccccgcacg
    13201 ccatcgcgct gggcgaggcc ttccagctga ccaacttcct gcgcgacgtc gccgaggacg
    13261 tcgaccgggg ccgggtctac ctgcccgccg acctcatggc cgcgcacggc gtcacccgcg
    13321 agcaactcgc cgagaagcgg tacgacaccc acttccggga gctgatgcgg gagatggtcg
    13381 ccatcgtgcg ccgccgctac gacgacgccg cccccgggac gccgatgctc gcgccggagt
    13441 cccgcgactg cgtgcgcgcc gccaccgacc tctacggcgg catcctcacc gagatcgagc
    13501 gggccgacta ccgggtgctc gaccgccggg tgcgggtgtc caggccacgg cgtctggcgg
    13561 tgttcgcccg ccggttgacc gccgcccagc tggccagggt cagggtcacc atggcgaagc
    13621 cgaacagcag gtcctcgacc ggcgcgtagg cgatccgcgg gccccagatg gtgtccgggt
    13681 cgtaggtgac gacgtccagc ccggtcagca cgccgttcat gagcagctgg aacgtgacga
    13741 tgatcgcgta ggccacccag aacactggcc gggtgaccat gcgggtgcgg tagacggcca
    13801 ggtccagccc gaggacggcg agcaccgcgg tgaccgcgag ggcgctgtag ctcaccggcc
    13861 ggtcccggct tcctcagccg ggtacccggc gtcccagccg gtgaccttgc gcacggcctc
    13921 cagcgccagc accgagcaca gcgggacgac gaggaagaac agcacctcct cgaccgggat
    13981 gccgccgggc agccggacgc cgagggtcag ccggtcggag tagtcccagt ggccctgcgc
    14041 gatcgcgtac agcacccaga cgacgaagac ggcgaactcc ggcgcgaccg cgaccagcag
    14101 ccgccgccag cgggcgtaca cccgcactcg cagcaggagc tcgagcggcg cggtgacgac
    14161 caggcagccg gccagcagcg cgaggtaggt cagctgcccc atctgtcggc gctcagaacg
    14221 ccagggcctg ggcgcgccgg gtgacctcgg tgtgccggtc gctgcgcagc gcctccacgg
    14281 gcgtgcccgg cagcgtgtcg tcggcgcgga acagccactc gaagacctcc gcgtcgctga
    14341 acccgccgtc cttgagcacg gtgatcaggc cgggcaggtg cttgaggacg gcgccgtcct
    14401 ggaggaagtc ggccgggatc cggctgttgc cgctgccggg gacggccatg agcttgtgct
    14461 cgcgcaacag ctggcggacc cggttcggcg agacccccag tacagcggcg acctcagcgg
    14521 gggtgagcgt ctccatgacg tccgagccta tgaccccccc gcggttcgcc gtgccgggga
    14581 cgccgacccg ccgtccagct gccccgatac catggggcgg ggccgtgact ggcgctgctg
    14641 aggtggacca ccaccgggga gcggtccgca ccaccccgcc gggcgcctgg gcacccactc
    14701 gtcgtcccct cgcgctggag ccctccatga ccgacgtcag cacccacgcc accgcaccct
    14761 ccgacgccgc cctgccccac gccgacgtcg cctccgccgc ctaccgcagc gcgctgcagg
    14821 tcatcggggc cgtggagccc cgggtggccg acgcgatcgg cgcggagctc gccgaccagc
    14881 gggcctcgct gaagctgatc gccagcgaga actacgccag ccccgccgtg ctgctcacca
    14941 tggggaactg gctgtcggac aagtacgccg agggcaccgt cgggcaccgc ttctacgccg
    15001 gctgccagaa cgtcgacacc gtcgaggcgc tggccgccga gcacgcccgc gagctgttcg
    15061 gcgccccgca cgcctacgtg cagccgcact cgggcatcga cgccaacctg gtcgccttct
    15121 gggcggtgct ggcctcccgc gtcgagtccc cggccctgga gaaggccggc gtccggcacg
    15181 tcaacgagct gaccgacgcc gactggtcgg cgctgcgcca ccagctcggc gaccagcgga
    15241 tgctcggcat gtccctggac gccggcggcc acctcaccca cggcttccgg ccgaacatca
    15301 gcggcaagat gttcgagcag tcctcctacg ggaccgaccc cgagtccggg ctgctggact
    15361 acgacgccgt ccgcgagcgg gcccgcgagt tccggccgct gatcctcatg gccggctact
    15421 ccgcctaccc gcgccgggtg gacttcgccc ggatgcgcga gatcgccgac gaggtgggcg
    15481 ccacgctggt cgtcgacatg gcccacttcg ccggcctggt cgccgggaag gtcttcaccg
    15541 gcgacttcga ccccgtgccg cacgcccacg tcgtcaccac cacgacgcac aagtcgttgc
    15601 gcggcccgcg cggcggcatg gtgctggccc agcccgagta cgccgacgcc gtcgaccgcg
    15661 gctgcccgat ggtgctcggc ggtccgctgc cgcacgtcat ggccgccaag gcggtcgcct
    15721 tcgccgaggc ccggcagccc gccttcgccg ggtacgcgca gcgcatcgtc gacaacgccg
    15781 tctccctcgc cgaggggctg acccgccgcg gcgcgcggct ggtcaccggc ggcaccgaca
    15841 accacctggt gctcgtcgac gtctccggct tcggcctcac cggtcgccag gcggagtccg
    15901 cgctgctgga cgcgggcatc gtgaccaacc gcaacgccgt cccggccgac ccgaacggtg
    15961 cctggtacac ctccggcatc cggctgggca ccccggcgct gaccacccgc ggcttcgggg
    16021 cggacgagtt cgaccgcacc gccgagctga tcgtcgacgt cctgtcgaac acgacgccga
    16081 ccgccacccg ggacggggcg ccgtccaagg ccaggtacgc gaccgccgac ggcctggccg
    16141 accggacccg cgacgcggcc gccgagctgc tggaccgcca cccgctctac cccggcctgg
    16201 agctctgagg gaagggacgc ggtctcaggt cccgcctcga ggggccggag gctccccgag
    16261 gcgggacggt cgaaggaccc cctgccccca ccgctcgcga gctcgcggtg ggcccctgca
    16321 gggggccgac gcggcacgtg gccgcgggtc gcgccgagcg gggggccgga ggctcccccg
    16381 aggcgggacg gggtggggct ccgcgtgggc cgacgcggca cgtggccgcg gtgacgtccg
    16441 gaggacgtcg gtgtaggtgt gacgggtgaa cccgtcacac cggccggcgc tccgcgtgta
    16501 cgggcggcgc agcgccgacc cgctcctaca ctcggccggg tggacaccgc cgtgaccgac
    16561 cccgtggtcg gcctcgtcct cgaggggagg tacctgctcg aggagcgcct cgcccgaggc
    16621 ggcatgtcca ccgtctacgc cgccaccgac ctccggctgc accgcaccgt cgcggtcaag
    16681 gtcatggccg agcacctggc gcacgacccg acgttcgtcg accggttcac ccgcgaggcg
    16741 cgggccgcgg cgatgctcag ccaccccaac gtcgtgtcgg tcagcgacca gggcagcgac
    16801 cagggcctgg tgttcctggt gatggagctg gtccgcggcc gcacgctgcg cgacctgctg
    16861 caggcccgcg gccggctcac cgtcgccgag gccttcgccg tcctggagcc ggtgctctcc
    16921 gggctcaccg ccgcccaccg cgccgggatc gtgcaccgcg acatcaagcc cgagaacgtg
    16981 ctcatcggcg ccgacggcgt ggtgaaggtc gccgacttcg gcctggcccg cgcgctcacc
    17041 ggcaccgggc agaccagcca caccggcggc gtgctcatcg gcaccgtcgc ctacctctcc
    17101 cccgagcagc tcgagcgcgg caaggccgac gcccgcagcg acgtctacgc cgccggtgtc
    17161 gtgctctacg agatgctcac cggccacccg ccctacgggg gcgacacccc gctggccgtg
    17221 gcctaccagc acgtgcacca cgacatgccc cggccgtcgg aggaggtgcc gggcctgccg
    17281 tgggaggtcg acgagctggt cgcgcgcacc acccgccgcg agccggccat ccgcccgctg
    17341 gacgccggcg cgttcctcgc cgacctcgag gacgtgcgca ccgacctggc catagagcgc
    17401 gtccccgtcc ccaccgggcg cgtccccgcc accgccgaca ccctgcggcc gaccaaccgg
    17461 cccagccgcc cgacccggca caccggcgac ccggccgctc cgcgtaccga ggtgctcggc
    17521 cccggtggga cccggcccgg gcgcgccagc ggccggacct cgatgctgcc cggggccggc
    17581 acgggcaccg acccgggtgc acggcggccc gcgccccagc gcgcccgccc cggcgtgccg
    17641 ccgcacatcc gccgccgccg cgcccggctc gccgtcgccc tcgtgctgct caccgcgatc
    17701 accatcggcg cggtcggctg gtggctgggg tccggccggt ggacgacggt gccgcagctg
    17761 gccggcaagg agcaggccgc ggcgatcgac ctgctgcagg aggccgggct gacccccgac
    17821 tgctgcgagg agcggttcag cgaggacgtc gccgacggcg tggtcatctc cgccgagccc
    17881 gagggcggcg aggccatccg gggcaccgac gtccggctgg tggtctccaa gggcccggag
    17941 cggttcgagg cgtccccgga cctggtgggc cagccgctgg acgcggtccg caccgcgctc
    18001 gagaaggtcc cggtggtcgt ccaagaggtg caggactacg acaacgaggt gccggtcggc
    18061 cacgtgaccg gcttcgaccc ggaggccggc accgagctca agcgcgacca ggagctggtg
    18121 gtctacgtca gccgcgggca cgagccggtg accgtgccgg ccgtcgtcgg gctctccccc
    18181 gacgaggcga cggccaacct ggagacgctc gggttcgccg tggagcgcac cgagggccgc
    18241 agcgccgacg tcgaccccgg cgaggtcatg gcggtcaccc cggccagcgg ccagcaggcg
    18301 ccctaccgga gcacggtcac cctgcaggtg tccgcggggc tgccccaggt gcaggtgccc
    18361 gacgtggtcg gccgcagcca gcaggaggca gccgcgctcc tgcagcaggc cggcctgcag
    18421 gtgcaggtca gccagttctt cggcgaccgg gtgatccggc agagcccggc cgccgggcag
    18481 acggtcgaca tcggcaccca ggtgacgatc ctggtgacgt tcgaacggga ctgaggacgc
    18541 tgcgtactgc tgcgggtgtg ccccccatcg gggcgcacat ccagatcaag ggcgggctgg
    18601 ccaagggcgg cctggcctac accgacgccg tcggcgcgcg ggccgtgcag gtcttcgtcg
    18661 gcaacccgcg gggctggaag ctgaccgcgg gggacccgcg ccaggacgcg ctgttcaccg
    18721 cgggctgcgc cgagcgcggg gtgccctcct tcatccacac gccgttcctg gtcaacgtcg
    18781 gctcccccac cgaggcgacc gtcgagcagt cgatcgcgac catcgcgcac aacctcgccc
    18841 gcggcgtcca gctcggctgc cagggcgtcg tcgtccacgc cgggtccgcc gtcggtgagg
    18901 accgctacga ggacgcgctg cgccagctgc acgagcggct gctgccggtg ctcgaggccg
    18961 cgccggacga cggcccgcgg ctgctggtcg agccgacggc cggtggcggc aggtcgctgg
    19021 ccgccaccgt cgaggacctc ggcccgtact tcgccgcgct cgagcaccac ccactgctcg
    19081 gcgtctgctt cgacacctgc cacgcctggg cggccggcca cgagctgacc gcgcccggcg
    19141 gcacggccgc gaccctggac gcgctcgagg ccgccgtcgg ccccggccgg ctgggcctgg
    19201 tgcacgccaa cgactcgctc gacgagtgcg gctccaagcg ggacaggcac accaccatcg
    19261 gcgccggcac gatcggggtg gcgccgttcg cggagctgct ggcccacccc tcgatggccg
    19321 gcgtcccggt cgtcgtggag acgcccagcg agcgggacgg cgtggcctcg gccgggcacg
    19381 cggccgacat cgcgctgctc aacgagctcg cggtcctccg gaccgcaccg cggccaggtg
    19441 ccgtccccct ggcgagctga gctgctgcgt cccgcctgcg cggacccctc cggggcccac
    19501 ttcggcgcga caggtccccc gagacgggca tggcgcgtcc gggtgacacg cggacatgac
    19561 gctgtgggcc cgcgcgctca cttgcggtag tcctcgccgc accgttggct gcagggaccg
    19621 cggtcgcccg gccgcggcga agccgtccga ggagccgtca cttgcccact cgccgcaccc
    19681 tggccgccgg cctcgtcgcc gccctcgcga cggccggcct cggcgccacc gccgccccgg
    19741 ccgccgccgc cccgtccgac ggtccgcgcg ccacctacgt cgtcaccgtc gaccgctcga
    19801 cgctgcccgt gcaggcagcc gagcgggccc gcggcctcgg cgggcaggtc gaccacgtct
    19861 acaccacagc actggccggc ttcgccgtca cgctcccgga ggccgccgcg agccggctgt
    19921 cggccatccc cggggtcgtc gccgtcgagc gggaccaggc cgtcaccacc gacgagtccc
    19981 agtccggcgc gacgtggggc ctggaccgca ccgaccagcg cgacctgccc ctcgacacca
    20041 cctacggctg gaccacgacc ggcgcggggg tcaccgccta cgtcatcgac accggcatcg
    20101 ccgccggcca caccgagttc accggccgcg tgggcgccgg cttcgacgcg gtcgacggcg
    20161 gcgcgcccga cgactgcaac ggccacggca cgcacgtcgc gggcaccgtc ggcgggacga
    20221 cgtacggcgt cgcgaagggc gtgcggctgg tcggcgtccg cgtgctcggc tgcgacggca
    20281 gcggcaccac cgccggtgtg gtcgccggca tcgactgggt cacggccgac caccaggccg
    20341 gcgcacccgc ggtcgccaac atgagcctcg gcggcgggac cagcaccgcc atcgacgccg
    20401 cggtgcgcaa ctccatcgcc gacggggtga gctacgcggt ggcggcgggc aacggcagct
    20461 ccgccggcgt ggcccaggac gcctgcgcct cctcccccgc gcgggtgccg aacgcgctca
    20521 ccgtcggcgc gaccgaccgc accgaccagg cggcgtcgtt cagcaactac ggctcctgcg
    20581 tcgacctgtt cgctcccggc gtcggcatca ccagcgcctg gtacacgggc agcaccgcga
    20641 ccaacacgat cagcgggacg tcgatggcca cgccgcacgt cgcgggcgtc gccgcgctcg
    20701 tgctgtcgac cacgccgtcc gcgccgccgg ccacggtcgc cgcgacggtc accgccgccg
    20761 cgactcccgg ccacgtcgtc ctgtcgcgga cggccacccg ggccgggacc ccgaaccggc
    20821 tgctgtacag ctcctactga tccacccggc gacggtgtgc gcggatgcgc ggctctccgg
    20881 tccggagccg cgcatccgcg cacagcgtcg ggtcagcagc ggccgccagc ggcgaccgcc
    20941 ggccctcaac ggtcgaggat cccggcgagc acgtcgccag cgcgctcgac ggcggcgcgg
    21001 tcgacgccca ggttggtcac cagccgcagc cgccggtcgc tgacctgcga cacgagcacc
    21061 ccctgcgcct tggcggcctc ggccacgacc ggcgcgggga cgtcgtccag ccggacgatg
    21121 ttggtctgca ccgtggccgg gtcgacgccg aggcgcttgg ccagcaactg cgcgtgctcg
    21181 tggtcctcgg ccagccgatc gaggtgggcg tccagcgcgt acagccccgc cgcggcgagc
    21241 accccggcct gccgcatccc gccaccgagc cgcttgcgcc acagccgggc ggcggcgatc
    21301 cgctcggccg aggcgacgag caccgacccg accggggcgc ccagcccctt ggacaggcag
    21361 accgaggcgg tgtcggccag cccgccgtag gtggccaggt cgacgccgga ggccacggag
    21421 gcgttccaga ttcgggcccc gtcgaggtgc acgtcgacgc cggcctgccg cgaccagtcc
    21481 cacagcgcct gcagctgctc cagcggctgc accagcccgc cgccgcggtt gtgcgtgttc
    21541 tccacggcga tcgccgcggt cgcggtgagg tgccagttgt cccgcgggcg cacctgctcg
    21601 acgagctgcg cggtgtcgag ccggccgccg tccgacacga ccgtgcgggt ggagatgccg
    21661 aagagcaccg ccgccgcacc catctcgtag gtgacgatgt gcgcctcggc gtcgcagagc
    21721 acctcctggc ccggctcgca gaccagccgc aggccgatct ggttgcccat cgtccccgac
    21781 ggcacgaaca gcccggcctc gtggccgaac atcccggcca cccgctcctc gagcgcgttg
    21841 atcgccgggt cctcgccgta gacgtcgtcc ccgacctcgg cctcggccat cgcccggcgc
    21901 atgccgggcg tcggcttcgt gaccgtgtcg gagcgcaggt cgaccacgtc agccacgcag
    21961 catctccgcg accaggaagg cgagctccag cgactgcccg gtgttcagcc gcgggtcgca
    22021 ggcggtctcg tagcggctgt tgaggtcctc gtcgctgatc tccatggccc cgccgaggca
    22081 ctcggtgacg tcctcaccgg tgagctcgac gtggatgccg ccgggccagg tgcccagagc
    22141 ccggtggacg tcgaagaagc cgagcacctc gtcgacgacc cggtcgaagt gccgggtctt
    22201 gtagccggtg gaggactcgt gcgtgttgcc gtgcatcggg tcgcactgcc agacgacctg
    22261 gtggccgctg gcggtcacct tctccacgat cgcgggcagg acgtcgcgga tcttgccgtt
    22321 gcccatccgg ctgatcaggg tcagccggcc cgggatgccc tcggggtcga gccgctcgac
    22381 gagctcggtc gcctgctcgg gggacgtcgt cgggccgatc ttgacgccga tcgggttggc
    22441 gatccgcgac atgaactcca cgtgcgcgcc gtcgagctgg cgggtgcgct ccccgatcca
    22501 gacgaagtgc gccgaggcgg cgtagggccg gccctcgtgc acccgcagca gcgcccgctc
    22561 gtagtcgagg atcagcccct cgtggctgtt gtagagctcc acgccgcgca gcgcggtgtc
    22621 gtcgacgccg caggccttca tgaacgccag cgcccggtcg atctcgcggg cgatcacctc
    22681 gtagcgcacg cccgccggag agctggcgac gaagtccttg ttccagtcgt gcacggcgtg
    22741 caggtcggcc atgccaccgc gggcgtaggc gcggatcatg ttcatcgcgg ccgcggagtt
    22801 ggcgtaggcg cgcaccagcc ggttcgggtc cgggatgcgc ttctccagca ccggctccag
    22861 cgagttgacc atgtcgccgc ggtaggaggg caggccgagg gcgtcggtgt tcgacgagcg
    22921 gggcttggcg tactgcccgg ccacccggcc caccttgacc accggcacgc tcgcgccgta
    22981 ggtcaggacg acggccatct gcagcagcgt ccgcgtggtg ctctgcaggt gcgcgtcggt
    23041 gttgaggtcg aaggtctccg cgcagtcacc gccctggagc aggaacgccc ggccctgcgc
    23101 cacctcggcc agccgcgtgc gcagctcgtc gacctcgctg ggcgccacga tgggcggcac
    23161 ggaggagagg gtggccagga cggtgtccag tgcggcgcgg tcgggccact ccggctgctg
    23221 ggcggcgggc agctcccgcc accggtccag gtcgggcagc agggcagccg ggtcggagag
    23281 ggtcacgccc tcagagggta ccggcggctc tgccgcagcc ctcgccgcga gcctcgtgac
    23341 gtcctggaac ggcctccccg cagggtccgc cgcgagcctg cgagtggcgg ggggcaggga
    23401 ggtcctcctt cagccgaaga agacctcgac ctccgcgtac cggtcgaccg ggaccagctt
    23461 cagctgcgcg gtggcctcgg ccaggggcac ccgcacgatg tcggtgcccc gcagcgccac
    23521 catcaccccg gtctccccgg cgtgcaccgc gtcgagcgcg gccaggccga agcgggtggc
    23581 cagcacccgg tcgaacggcg agggggtgcc gccgcgctgg atgtgcccca ggacgacggc
    23641 gcgggactcc cggccggtgc gctcctcgat caccgaggcc agcgcggtgc cgatcccgcc
    23701 gagccggacg tggccgaacg cgtccttctc gcccgtggcc gtcaccaggt cgccgtcctt
    23761 gggcttggcg ccctcggaga ccaccacgat cggggagtag ccggagtcga accggcgctg
    23821 gcagtgctcc acgacggcgt cgacgtcgaa gggctgctcg gggatgagga cgacggtggc
    23881 gccgccggcc atcccggcgt gcagggcgat ccaccctgcg tgccggccca tgacctcgac
    23941 cacgagcgtg cggtggtggc tgtccccggt ggtgtgcagc cggtcgatgg cctcggtggc
    24001 cacgccgagc gcggtgtcga agccgaaggt gtagtcggtg gcgtcgaggt cgttgtcgat
    24061 ggtcttgggg acgccgacca cccgcacgcc ggcctcggcg agcttggtgg ccacgccgag
    24121 ggtgtcctcg ccgccgatcg ggatcagcgc gtcgacaccg agccgctcga gcgtggcgag
    24181 cacccggtcg gcgccgccct cc
//
