GCF_900102715.1 - 4 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

NZ_FNJX01000003.1 (Streptococcus equinus (Streptococcus bovis))

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 3.1	arylpolyene	80,646	122,838

NZ_FNJX01000002.1 (Streptococcus equinus (Streptococcus bovis))

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 4.1	lanthipeptide-class-ii,terpene-precursor	59,877	93,338	Medium	streptococcin A-FF22	ribosomal:RiPP:Lanthipeptide

NZ_FNJX01000001.1 (Streptococcus equinus (Streptococcus bovis))

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 6.1	RiPP-like	196,296	206,623
Region 6.2	T3PKS	796,459	837,637

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 3.1	arylpolyene	80,646	122,838
Region 4.1	lanthipeptide-class-ii,terpene-precursor	59,877	93,338	Medium	streptococcin A-FF22	ribosomal:RiPP:Lanthipeptide
Region 6.1	RiPP-like	196,296	206,623
Region 6.2	T3PKS	796,459	837,637

No secondary metabolite regions were found in these records:: NZ_FNJX01000005.1 (Streptococcus equinus (Streptococcus bovis)); NZ_FNJX01000004.1 (Streptococcus equinus (Streptococcus bovis)); NZ_FNJX01000006.1 (Streptococcus equinus (Streptococcus bovis))

Compact view

NZ_FNJX01000003.1 - Region 1 - arylpolyene

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Location: 80,646 - 122,838 nt. (total: 42,193 nt) Show pHMM detection rules used

arylpolyene: (APE_KS1 or APE_KS2)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

BLR40_RS07325: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Ligases: synthase

BLR40_RS07290: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

BLR40_RS07375: pseudouridine synthase

smcogs: SMCOG1279: pseudouridine synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000107.3	0.56	PKS	naphthopyrone	Aspergillus nidulans FGSC A4
BGC0001258.3	0.56	PKS	1,3,6,8-tetrahydroxynaphthalene	Glarea lozoyensis
BGC0001257.3	0.56	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0000888.5	0.49	other (other)	bacilysin	Bacillus sp. CS93
BGC0002510.2	0.47	PKS	youssoufene A1, youssoufene B1, youssoufene B2, youssoufene B3, youssoufene B4	Streptomyces sp.
BGC0002404.2	0.45	other (other)	falcarindiol	Solanum lycopersicum
BGC0001987.2	0.44	PKS	koreenceine A, koreenceine B, koreenceine C, koreenceine D	Pseudomonas koreensis
BGC0001197.5	0.44	PKS	frankiamicin	Frankia sp. EAN1pec
BGC0001184.4	0.44	other (other)	bacilysin	Bacillus velezensis FZB42
BGC0000204.5	0.43	PKS	benastatin A, benastatin B, BE-43767, TAN1532B	Streptomyces sp. A2991200

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000107.3	0.56	PKS	naphthopyrone	Aspergillus nidulans FGSC A4
BGC0001258.3	0.56	PKS	1,3,6,8-tetrahydroxynaphthalene	Glarea lozoyensis
BGC0001257.3	0.56	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0000888.5	0.49	other (other)	bacilysin	Bacillus sp. CS93
BGC0002510.2	0.47	PKS	youssoufene A1, youssoufene B1, youssoufene B2, youssoufene B3, youssoufene B4	Streptomyces sp.
BGC0002404.2	0.45	other (other)	falcarindiol	Solanum lycopersicum
BGC0001987.2	0.44	PKS	koreenceine A, koreenceine B, koreenceine C, koreenceine D	Pseudomonas koreensis
BGC0001197.5	0.44	PKS	frankiamicin	Frankia sp. EAN1pec
BGC0001184.4	0.44	other (other)	bacilysin	Bacillus velezensis FZB42
BGC0000204.5	0.43	PKS	benastatin A, benastatin B, BE-43767, TAN1532B	Streptomyces sp. A2991200

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.06 out of 27.78

Confidence: medium

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.09 out of 20.97

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.38 out of 26.06

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.23 out of 26.06

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.06 out of 26.06

Confidence: medium

AfsQ1

Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 17.23 out of 19.52

Confidence: medium

Additional weak hits (4):

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 22.56 out of 36.53

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 23.47 out of 28.14

Confidence: weak

NuR

Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 22.51 out of 30.98

Confidence: weak

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.68 out of 26.85

Confidence: weak

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS substrates

TFBS Finder

NRPS/PKS substrate predictions

BLR40_RS07330: pk

PKS_AT (72..205): pk

ATSignature: (unknown)

No matches above 50%

minowa: trans-1,2-CPDA

Prediction, score:

trans-1,2-CPDA: 0.0
inactive: 0.0
fatty_acid: 0.0
Propionyl-CoA: 0.0
Methylmalonyl-CoA: 0.0
Methoxymalonyl-CoA: 0.0
Malonyl-CoA: 0.0
Isobutyryl-CoA: 0.0
Ethylmalonyl-CoA: 0.0
CHC-CoA: 0.0
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description
AfsQ1	Two-component system AfsQ1-Q2, activator of antibiotic production
CcpA	Catabolite control protein A
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
MogR	Repressor of flagellar motility genes

NZ_FNJX01000002.1 - Region 1 - lanthipeptide-class-ii,terpene-precursor

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Location: 59,877 - 93,338 nt. (total: 33,462 nt) Show pHMM detection rules used

lanthipeptide-class-ii: cds(LANC_like and DUF4135)
terpene-precursor: (PT_FPPS_like and not PT_HPP)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lanthipeptides

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: carbamoyltransferase

BLR40_RS04980: ornithine carbamoyltransferase

smcogs: SMCOG1114: ornithine carbamoyltransferase

Lyases: cyclase

BLR40_RS05030: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

Ligases: synthetase

BLR40_RS05085: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000547.5	0.59	ribosomal	salivaricin 9	Streptococcus salivarius
BGC0000557.5	0.56	ribosomal	streptococcin A-FF22	Streptococcus pyogenes
BGC0000532.3	0.49	ribosomal	mutacin II	Streptococcus mutans
BGC0000562.3	0.47	ribosomal	variacin	Kocuria varians
BGC0001788.3	0.47	ribosomal	suicin 65	Streptococcus suis
BGC0000521.3	0.47	ribosomal	lacticin 481	Lactococcus lactis subsp. lactis
BGC0000539.5	0.43	ribosomal	nukacin ISK-1	Staphylococcus warneri
BGC0000526.5	0.42	ribosomal	macedocin	Streptococcus macedonicus
BGC0000527.5	0.35	ribosomal	mersacidin	Bacillus sp. HIL-Y85/54728
BGC0000626.3	0.35	ribosomal	thuricin	Bacillus thuringiensis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000532.3	0.78	ribosomal	mutacin II	Streptococcus mutans
BGC0000562.3	0.77	ribosomal	variacin	Kocuria varians
BGC0000547.5	0.72	ribosomal	salivaricin 9	Streptococcus salivarius
BGC0000557.5	0.70	ribosomal	streptococcin A-FF22	Streptococcus pyogenes
BGC0001788.3	0.66	ribosomal	suicin 65	Streptococcus suis
BGC0000521.3	0.63	ribosomal	lacticin 481	Lactococcus lactis subsp. lactis
BGC0000499.3	0.61	ribosomal	butyrivibriocin OR79	Butyrivibrio fibrisolvens
BGC0000526.5	0.61	ribosomal	macedocin	Streptococcus macedonicus
BGC0000539.5	0.59	ribosomal	nukacin ISK-1	Staphylococcus warneri
BGC0000527.5	0.55	ribosomal	mersacidin	Bacillus sp. HIL-Y85/54728

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Lanthipeptide predictions

Lanthipeptide(s) for BLR40_RS05030

BLR40_RS05025

Leader:

MKNTNIIDIKATEALQELSLEELDTIIGA

Core:

KKGSGVVPTVSHDCHMNSWQFLFTCCS

Core with dehydrations:

KKGDhaGVVPDhbVDhaHDCysHMNDhaWQFLFDhbCysCysDha

antiSMASH-DB 4.0 matches for BLR40_RS05025

100.0%

NZ_CP046629.1and 3 others:

NZ_FNJX01000002.1 Lanthipeptides: BLR40_RS05025_lanthipeptideNZ_FNZS01000001.1 Lanthipeptides: BMX70_RS03125_lanthipeptideNZ_FOLK01000002.1 Lanthipeptides: BM262_RS05670_lanthipeptide

Lanthipeptides: GPA00_RS05740_lanthipeptide

KKGSGVVPTVSHDCHMNSWQFLFTCCS

85.2%

NZ_CP051645.1and 2 others:

NZ_JAKVFF010000018.1 Lanthipeptides: MKR34_RS11425_lanthipeptideNZ_VDOJ01000018.1 Lanthipeptides: FSV48_RS11975_lanthipeptide

Lanthipeptides: HHJ99_RS13350_lanthipeptide

KKGSGVVPTVSHDCHMNSWQFLFTCCS

KK SGV+PTVSHDCHMNS+QF+FTCCS

KKKSGVIPTVSHDCHMNSFQFVFTCCS

81.5%

NZ_CP046304.1:

Lanthipeptides: FOC54_RS00030_lanthipeptide

KKGSGVVPTVSHDCHMNSWQFLFTCCS

KK SGV+PTVSHDCHMN++QF+FTCCS

KKKSGVIPTVSHDCHMNTFQFMFTCCS

with 73 more sequence matches

Only the first 10 are displayed here.

74.1%

NZ_CP069183.1:

Lanthipeptides: LLNCDO700_RS13730_lanthipeptide

KKGSGVVPTVSHDCHMNSWQFLFTCCS

K GSGV+ T+SH+C+MNSWQF+FTCCS

KGGSGVIHTISHECNMNSWQFVFTCCS

70.4%

NC_012470.1and 11 others:

NZ_CABY01000005.1 Lanthipeptides: SZBHS5_RS06485_lanthipeptideNZ_CP029398.1 Lanthipeptides: DF184_RS05185_lanthipeptideNZ_CP029398.1 Lanthipeptides: DF184_RS05180_lanthipeptideNZ_CP078012.1 Lanthipeptides: KV238_RS09835_lanthipeptideNZ_CP078012.1 Lanthipeptides: KV238_RS09830_lanthipeptideNZ_JAFLMI010000009.1 Lanthipeptides: J0638_RS05350_lanthipeptideNZ_JAFLMI010000009.1 Lanthipeptides: J0638_RS05345_lanthipeptideNZ_LR738724.1 Lanthipeptides: GPW69_RS05065_lanthipeptideNZ_LR738724.1 Lanthipeptides: GPW69_RS05060_lanthipeptideNZ_VZNS01000007.1 Lanthipeptides: F6P79_RS05580_lanthipeptideNZ_VZNS01000007.1 Lanthipeptides: F6P79_RS05575_lanthipeptide

Lanthipeptides: SZO_RS04070_lanthipeptide

SGVVPTVSHDCHMNSWQFLFTCCS

+GV T+SH+CHMNSWQFLFTCCS

NGVFKTISHECHMNSWQFLFTCCS

70.4%

NZ_CP026729.1:

Lanthipeptides: BKKJ1_RS07010_lanthipeptide

GSGVVPTVSHDCHMNSWQFLFTCC

G+GVV T+SH+C+MNSWQFLFTCC

GNGVVTTISHECNMNSWQFLFTCC

70.4%

NZ_GL882519.1:

Lanthipeptides: HMPREF9056_RS03330_lanthipeptide

GSGVVPTVSHDCHMNSWQFLFTCCS

G+GV T+SH+CHMNSWQF+FTCCS

GNGVYYTLSHECHMNSWQFIFTCCS

70.4%

NZ_JH792236.1and 1 other:

NZ_JH792236.1 Lanthipeptides: IIM_RS26240_lanthipeptide

Lanthipeptides: IIM_RS26245_lanthipeptide

GSGVVPTVSHDCHMNSWQFLFTCCS

GSGV+ T+SH+CHMNSWQ +FTCCS

GSGVIKTISHECHMNSWQAIFTCCS

70.4%

NZ_VDNV01000006.1:

Lanthipeptides: FSV44_RS08765_lanthipeptide

GSGVVPTVSHDCHMNSWQFLFTCCS

G GV+ T+SH+C MNSWQFLFTCCS

GGGVIQTISHECRMNSWQFLFTCCS

66.7%

NC_012470.1and 2 others:

NZ_CABY01000005.1 Lanthipeptides: SZBHS5_RS06490_lanthipeptideNZ_CP078012.1 Lanthipeptides: KV238_RS09840_lanthipeptide

Lanthipeptides: SZO_RS04065_lanthipeptide

SGVVPTVSHDCHMNSWQFLFTCCS

+G + T+SH+CHMNSWQFLFTCCS

NGAIKTISHECHMNSWQFLFTCCS

66.7%

NZ_CP023483.1:

Lanthipeptides: CNY62_RS11970_lanthipeptide

GSGVVPTVSHDCHMNSWQFLFTCCS

G+G + T+SH+CHMN+WQFLFTCCS

GNGAIRTISHECHMNTWQFLFTCCS

66.7%

NZ_CP072384.1:

Lanthipeptides: J5A65_RS01395_lanthipeptide

GSGVVPTVSHDCHMNSWQFLFTCC

G GVVPTV+H+CHMNSWQ+ F CC

GRGVVPTVTHECHMNSWQWFFGCC

66.7%

NZ_JAEEGA010000010.1:

Lanthipeptides: I6N95_RS15660_lanthipeptide

GSGVVPTVSHDCHMNSWQFLFTCCS

G+GV+ T+SH+CHMNSWQ++FTCCS

GNGVIKTISHECHMNSWQWIFTCCS

MIBiG 4.0 matches for BLR40_RS05025

14.8%

BGC0000468.5 (CCM09443.1)and 2 others:

BGC0000469.6 (AFV25481.1) Bottromycin: bottromycin A2BGC0001157.6 (CBG72694.1) Bottromycin: bottromycin A2

Bottromycin: bottromycin A2

PTVSHDC

P V DC

PVVVFDC

14.8%

BGC0000470.6 (AFU90404.1):

Bottromycin: bottromycin D

PTVSHDC

P V DC

PAVVFDC

11.1%

BGC0002111.3 (EVG22_32245)and 1 other:

BGC0002111.3 (multiple genes) Lanthipeptide: andalusicin A or andalusicin B

Lanthipeptide: andalusicin A or andalusicin B

TVSHDC

T+S++C

TISNNC

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
sesquiterpene precursor		FPP	C15	acyclic	PP

Genes with terpene domains:

BLR40_RS05085: PT_FPPS_like

Domain 1 (25 - 282): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: Farnesyl diphosphate synthase, bacterial

Reactions:: DMAPP, IPP → FPP

Transcription Factor Binding Sites

Binding sites found:

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.57 out of 18.57

Confidence: strong

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.57 out of 18.57

Confidence: strong

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 18.79 out of 21.84

Confidence: medium

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.93 out of 30.25

Confidence: medium

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 23.60 out of 30.25

Confidence: medium

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 23.60 out of 30.25

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.49 out of 27.78

Confidence: medium

LexA variant 3

Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 23.99 out of 32.93

Confidence: medium

Additional weak hits (2):

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.48 out of 30.25

Confidence: weak

NuR

Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 23.65 out of 30.98

Confidence: weak

Lanthipeptides

Terpene

TFBS Finder

Core peptide predictions

BLR40_RS05025 - Class II

Cleavage pHMM score: 5.40

RODEO score: 0

Monoisotopic mass: 2889.3 Da

Molecular weight: 2891.3 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 2909.3 Da N = 1; 2927.3 Da N = 2; 2945.4 Da N = 3

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
IPP	Isopentenyl diphosphate
PP	Diphosphate

TFBS definitions

Regulator	Description
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
ColR	Phenol-responsive regulator
LexA variant 3	Repressor of DNA damage response
MexT	Global virulence regulator
ToxT	Regulator of MSHA biosynthesis

NZ_FNJX01000001.1 - Region 1 - RiPP-like

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Location: 196,296 - 206,623 nt. (total: 10,328 nt) Show pHMM detection rules used

RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

No tailoring functions detected.

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000617.5	0.47	ribosomal	coagulin	Bacillus coagulans
BGC0002579.2	0.45	ribosomal	carnobacteriocin XY	Carnobacterium maltaromaticum
BGC0000624.3	0.44	ribosomal	salivaricin CRL1328 α peptide, salivaricin CRL1328 β peptide	Lactobacillus salivarius
BGC0002577.2	0.41	ribosomal	lactococcin G	Lactococcus lactis
BGC0000494.5	0.32	ribosomal	uberolysin	Streptococcus uberis
BGC0000094.5	0.29	PKS, saccharide	methymycin	Streptomyces venezuelae
BGC0000055.5	0.23	PKS, saccharide	erythromycin A, erythromycin B, erythromycin C, erythromycin D	Saccharopolyspora erythraea NRRL 2338
BGC0000054.5	0.20	PKS	erythromycin	Aeromicrobium erythreum

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000617.5	0.47	ribosomal	coagulin	Bacillus coagulans
BGC0002579.2	0.45	ribosomal	carnobacteriocin XY	Carnobacterium maltaromaticum
BGC0000624.3	0.44	ribosomal	salivaricin CRL1328 α peptide, salivaricin CRL1328 β peptide	Lactobacillus salivarius
BGC0002577.2	0.41	ribosomal	lactococcin G	Lactococcus lactis
BGC0000494.5	0.32	ribosomal	uberolysin	Streptococcus uberis
BGC0000094.5	0.29	PKS, saccharide	methymycin	Streptomyces venezuelae
BGC0000055.5	0.23	PKS, saccharide	erythromycin A, erythromycin B, erythromycin C, erythromycin D	Saccharopolyspora erythraea NRRL 2338
BGC0000054.5	0.20	PKS	erythromycin	Aeromicrobium erythreum

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 24.91 out of 26.06

Confidence: strong

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 21.25 out of 25.88

Confidence: medium

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 19.08 out of 23.79

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.30 out of 28.19

Confidence: medium

Additional weak hits (2):

HypR

Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 18.94 out of 22.40

Confidence: weak

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 24.15 out of 35.63

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
IolR	Regulator of the inositol catabolism
MogR	Repressor of flagellar motility genes
PsrA	Oleic acid responsive regulator
ZuR variant 1	Zinc-responsive repressor

NZ_FNJX01000001.1 - Region 2 - T3PKS

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Location: 796,459 - 837,637 nt. (total: 41,179 nt) Show pHMM detection rules used

T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxidoreductase reductase

BLR40_RS03850: aldo/keto reductase family oxidoreductase

smcogs: SMCOG1039: aldo/keto reductase family oxidoreductase

BLR40_RS03925: hydroxymethylglutaryl-CoA reductase

smcogs: SMCOG1187: hydroxymethylglutaryl-CoA reductase

Isomerases: isomerase

BLR40_RS04015: isochorismate synthase

smcogs: SMCOG1018: isochorismate synthase

Ligases: synthase

BLR40_RS03930: hydroxymethylglutaryl-CoA synthase

smcogs: SMCOG1043: hydroxymethylglutaryl-CoA synthase

Translocases: permease

BLR40_RS03955: phenylalanine-specific permease

smcogs: SMCOG1038: phenylalanine-specific permease

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002561.3	0.45	other (other)	phenazine SA, phenazine SB, phenazine SC	Streptomyces sp.
BGC0000016.4	0.44	other (other)	amphotericin B	Streptomyces nodosus
BGC0002707.2	0.41	terpene	(+)-δ-cadinol	Coniophora puteana RWD-64-598 SS2
BGC0000513.3	0.41	ribosomal	Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3	Saccharopolyspora erythraea NRRL 2338
BGC0001080.5	0.41	other (phenazine)	endophenazine A, endophenazine B	Streptomyces anulatus
BGC0002031.3	0.41	other (other)	kitasetaline	Kitasatospora setae KM-6054
BGC0000883.5	0.41	other (other)	arginomycin	Streptomyces arginensis
BGC0000934.4	0.41	other (phenazine)	5-acetyl-5,10-dihydrophenazine-1-carboxylic acid, 5-(2-hydroxyacetyl)-5,10-dihydrophenazine-1-carboxylic acid, endophenazine A1, endophenazine F, endophenazine G	Kitasatospora sp. HKI 714
BGC0001789.3	0.41	ribosomal	suicin 90-1330	Streptococcus suis
BGC0000286.3	0.40	PKS	viguiepinol	Streptomyces sp. KO-3988

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002561.3	0.45	other (other)	phenazine SA, phenazine SB, phenazine SC	Streptomyces sp.
BGC0000016.4	0.44	other (other)	amphotericin B	Streptomyces nodosus
BGC0002707.2	0.41	terpene	(+)-δ-cadinol	Coniophora puteana RWD-64-598 SS2
BGC0000513.3	0.41	ribosomal	Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3	Saccharopolyspora erythraea NRRL 2338
BGC0001080.5	0.41	other (phenazine)	endophenazine A, endophenazine B	Streptomyces anulatus
BGC0002031.3	0.41	other (other)	kitasetaline	Kitasatospora setae KM-6054
BGC0000883.5	0.41	other (other)	arginomycin	Streptomyces arginensis
BGC0000934.4	0.41	other (phenazine)	5-acetyl-5,10-dihydrophenazine-1-carboxylic acid, 5-(2-hydroxyacetyl)-5,10-dihydrophenazine-1-carboxylic acid, endophenazine A1, endophenazine F, endophenazine G	Kitasatospora sp. HKI 714
BGC0001789.3	0.41	ribosomal	suicin 90-1330	Streptococcus suis
BGC0000286.3	0.40	PKS	viguiepinol	Streptomyces sp. KO-3988

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.69 out of 26.06

Confidence: medium

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 23.60 out of 30.25

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.73 out of 26.06

Confidence: medium

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.98 out of 20.97

Confidence: strong

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.57 out of 18.57

Confidence: strong

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.58 out of 27.78

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 24.52 out of 28.19

Confidence: strong

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 23.18 out of 28.19

Confidence: medium

Additional weak hits (3):

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.41 out of 30.25

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.61 out of 29.38

Confidence: weak

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 23.74 out of 35.63

Confidence: weak

Detailed domain annotation

Selected features only

Show module domains

TFBS Finder

TFBS definitions

Regulator	Description
CcpA	Catabolite control protein A
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
ColR	Phenol-responsive regulator
MogR	Repressor of flagellar motility genes
ToxT	Regulator of MSHA biosynthesis
ZuR variant 1	Zinc-responsive repressor