LOCUS       NZ_FNAJ01000005        11653 bp    DNA     linear   CON 22-APR-2024
DEFINITION  Myxococcus virescens strain DSM 2260, whole genome shotgun sequence.
ACCESSION   NZ_FNAJ01000005
VERSION     NZ_FNAJ01000005.1
KEYWORDS    WGS; RefSeq.
SOURCE      Myxococcus virescens
  ORGANISM  Myxococcus virescens
            Bacteria; Myxococcota; Myxococcia; Myxococcales; Cystobacterineae;
            Myxococcaceae; Myxococcus.
REFERENCE   1
  AUTHORS   Varghese,N. and Submissions,S.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-OCT-2016) DOE - JOINT GENOME INSTITUTE, LBNL, 2800
            Mitchell Drive, Walnut Creek, CA 94598, 94598, USA
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_900101905.1-RS_2024_04_22
            Annotation Date                   :: 04/22/2024 02:08:20
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,594
            CDSs (total)                      :: 7,524
            Genes (coding)                    :: 7,456
            CDSs (with protein)               :: 7,456
            Genes (RNA)                       :: 70
            rRNAs                             :: 3, 2, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 3 (5S)
            partial rRNAs                     :: 2, 2 (16S, 23S)
            tRNAs                             :: 59
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 68
            CDSs (without protein)            :: 68
            Pseudo Genes (ambiguous residues) :: 0 of 68
            Pseudo Genes (frameshifted)       :: 15 of 68
            Pseudo Genes (incomplete)         :: 65 of 68
            Pseudo Genes (internal stop)      :: 7 of 68
            Pseudo Genes (multiple problems)  :: 17 of 68
            CRISPR Arrays                     :: 6
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 04:03:20
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 229625
            Orig. end                         :: 241278
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            FNAJ01000005.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..11653
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="3"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..11653
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..11653
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:6653](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..6653)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     misc_feature    70..81
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: medium, score: 18.76"
                     /tool="antismash"
     gene            85..2283
                     /locus_tag="BLU09_RS17020"
                     /old_locus_tag="SAMN04488504_105161"
     CDS             85..2283
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020480692.1"
                     /locus_tag="BLU09_RS17020"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04488504_105161"
                     /product="PQQ-binding-like beta-propeller repeat protein"
                     /protein_id="WP_167371103.1"
                     /transl_table=11
                     /translation="MTRIRIGQRWKREPAASPLDSIALELDGVDLLSGAVEESLAEVVP
                     SLVRSVAALAGGRQKLAQVSLPEAHLELVLRRMGPEVELLVANLSRPARLMRPPVRVEL
                     EELVEAVREAGERFLADVTRAGPKALATTVGQALKEPLKGLNRPARPPDEAPARPATRR
                     VEPTEVPGFGFEVRNAGAPMSRGAARGTAGLLAPLLAAGEVWLSLPGKPEAWRVPGPPF
                     LTTLELSRLAVELARTVELGESRFELAPAGAKPPLLVDLKSGQAKAGRTGTPFPLTGTV
                     LAAALFHLGESLAAAFAEADHALVANPYRMELAERCREGLSHLRGPVQPPEAKGAAREK
                     KARATGQGTSRPLKVPGRLRRLRFAKLWEKRGLPDAEESRLLLGRHGPVYCAPHLASAF
                     SRKDGELLWKRAAALGVAASADGHAVAADIARVYGFTGRGGGARWLHDHDGIPLGPLLL
                     RKDGLLLTLSEDRTVVAFAEATGREVWRLAPPRTQRSWLATQGHRALVGTDSGYLYGLD
                     LEDGQVRYRMRAPMPFHGPPVAWGRRFLAMLGRGSHWAVLLADAHTGESVWTYEPDLSH
                     LSAPLPVGSRVFIAGEREREGMLLCLDAKGRRLWERPLNLGPGPFALASLPRAVVVTSA
                     SGAATRVAASGTVDWRVGAAGEPLISALPAHTARDITLVPGERVRAVDPRGGQVLAEVQ
                     AGVGLVALQADVRLNLYFLDDAGTLSAYRLGSHFTVVE"
     gene            complement(2298..3212)
                     /locus_tag="BLU09_RS17025"
                     /old_locus_tag="SAMN04488504_105162"
     CDS             complement(2298..3212)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002638450.1"
                     /locus_tag="BLU09_RS17025"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04488504_105162"
                     /product="hypothetical protein"
                     /protein_id="WP_186817645.1"
                     /transl_table=11
                     /translation="MKRYFGVIVIVAGVLLAAVMSYRSASGRALEAQRDADQQRIHAEY
                     LERVGWMRANPDEASYRDELKPFFKNYFDQVDAHLTRFKGNTKFDDYLLELEKREESGA
                     KDDRAKDRKAFYEYTRKTFDSLREGRYRPVWSATDKGMRLDIISSDVVMVLGKPQIRLQ
                     LAVWGAQRVLKDDGKVLKMMTSATFDTVWKLTDAKGKLLGEMRGADPSMKIDHPERFVR
                     AFPPQMVLGHYDLDLLPNEVAKVEMTINLSSSAASGGTATATYVWKLDVPSEWKLGAGE
                     TWEGATQEERPEEEIDPSKAAAN"
     misc_feature    complement(3242..3256)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 17.0"
                     /tool="antismash"
     misc_feature    complement(3243..3256)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 14.01"
                     /tool="antismash"
     gene            3264..4295
                     /locus_tag="BLU09_RS17030"
                     /old_locus_tag="SAMN04488504_105163"
     CDS             3264..4295
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011554161.1"
                     /locus_tag="BLU09_RS17030"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04488504_105163"
                     /product="alpha/beta fold hydrolase"
                     /protein_id="WP_090490881.1"
                     /sec_met_domain="PF00561 (E-value: 6.5e-09, bitscore: 30.6,
                     seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIQATGTHLFTTPLPLEEGELLGNPQVAWAAYGEPSDGKAVVLLH
                     DLAHSHLALGPPEDSAYQPSGWGRALVGANLALDPAITPVFSPGLLGSPFGSTSPATVN
                     PASGERWGLELPPLTVQDMARAVSATLRAQGLTKVRALVGVGLGAHVALRLASLFPDLA
                     EGVVAIGAARALPEGVREKLGLSWQVLRADPDYRDGLYALDAPPRKTMRKLRLDFLKLL
                     CGREFLASAYPAPEAARAALEAEADAFADAFDAVSWASLCSAYAGSDVSDGFSRIRARV
                     LLVTGTSDAMAPMNRVRDTYHLLSAAGVSARFLELPGPGDHAALLQDAERLHGPLSDFL
                     RRC"
     gene            complement(4296..4931)
                     /gene="udk"
                     /locus_tag="BLU09_RS17035"
                     /old_locus_tag="SAMN04488504_105164"
     CDS             complement(4296..4931)
                     /EC_number="2.7.1.48"
                     /GO_function="GO:0004849 - uridine kinase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="udk"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011554162.1"
                     /locus_tag="BLU09_RS17035"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04488504_105164"
                     /product="uridine kinase"
                     /protein_id="WP_090490596.1"
                     /transl_table=11
                     /translation="MASPLVVGIAGGTASGKTTVARKVREALADCRVAFIDQDSYYRDL
                     KDLPLADRREVNFDHPDAFDRELLVQHLQALKSGHPIQKPVYDFVTSSRTPQTKNVDPG
                     DIILIEGILVLHMKEVRDEMDVKIYVDADDDLRILRRLTRDIKDRGRDFDHVVSQYLRH
                     VRPMHMGFVEPSKHFADIIIPHGGNNEIAIGMLVGALRGKLSGAVNRD"
     gene            complement(5001..6653)
                     /locus_tag="BLU09_RS17040"
                     /old_locus_tag="SAMN04488504_105165"
     CDS             complement(5001..6653)
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: DUF692"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002638453.1"
                     /locus_tag="BLU09_RS17040"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04488504_105165"
                     /product="DUF692 family multinuclear iron-containing
                     protein"
                     /protein_id="WP_244171788.1"
                     /sec_met_domain="DUF692 (E-value: 8.7e-26, bitscore: 85.5,
                     seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTHAVSETWTLPWRGLGLSSNLSVADVPQPYRLLDESPGLFDYVE
                     YSAPLSLEESKAHASLFPEMWRRRQDVPVLFHPVHLNLWGPALEPVQALRDLDAHARAV
                     ESPWVGNDVGWWHVDGQPFPGYLYFTPPFNEAGLEACVSHALQVQQHLSVPLALENPAV
                     LARRGQWHVLDFMAKLHARTGAPLLLDLGHLLSHQLSAGLPLETGLDGFPLDQVVELHI
                     AGGVVTHRGPRSFYVDDHTQPVREELFDLLASLIPRCPSLRAVTFEGDGHPPEVARMSL
                     RRLRQLVPAGARPPLTWRVPAAVAAVPPLTEDSQPWALFDAGYAAAPAASVEDEAGTLA
                     DQDFRLAVVAEVLDRDWPLTRLLLAGTREGLAAFTGSKEYRKLFDSVARTPGQSFASWA
                     MRRLRESPDEGASAALTLEMLLPSLFTRRVPAPAPGQVGLMEDVRVGSLPVDLSELVHS
                     ARAVRRHLTARAWACGTLELSGLDSLNQVARRPGPGPWSFVARRRAGGPDVMSVPLALG
                     EFLGMLAVRPMAEAEVAPGLLEAARARGLIRQG"
     gene            6770..7585
                     /locus_tag="BLU09_RS17045"
                     /old_locus_tag="SAMN04488504_105166"
     CDS             6770..7585
                     /EC_number="2.3.1.-"
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0016747 - acyltransferase activity,
                     transferring groups other than amino-acyl groups [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013940771.1"
                     /locus_tag="BLU09_RS17045"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04488504_105166"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_090490598.1"
                     /transl_table=11
                     /translation="MPAPSRVEIDESNAQYRGAWRRFALGSKSGEVVERPEVYITACHV
                     AWSMMNSAFLRAPVETEQALAAAAASAARYFSAGRHGWSFVVCDDWLAPSMRDNAPSIL
                     AWYGLKSEMDVTGMVADRLAPSIHPRPPFTMRPVTDTWGRQAVADINANVYDVPRHFGR
                     EAFDEDTLYTPDCQGFVACRDEEAAASTVVLRVDAAAYVALVATQPQYRRQGAAEAVMR
                     HALAKAHQDWGTERTVLHATSEGEPVYTRMGYRPVTRFRMYMAPPPGQG"
     misc_feature    complement(7646..7664)
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: weak, score: 19.38"
                     /tool="antismash"
     gene            7815..8648
                     /locus_tag="BLU09_RS17050"
                     /old_locus_tag="SAMN04488504_105167"
     CDS             7815..8648
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013940772.1"
                     /locus_tag="BLU09_RS17050"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04488504_105167"
                     /product="hypothetical protein"
                     /protein_id="WP_244171789.1"
                     /transl_table=11
                     /translation="MAKWDDLVLAIPPHAGGRSQAPAAVTLLETLLGLHEAQLTLLRGL
                     HRDVRPLQEGPFLAGRLHLDAVRAPQATRDEQLERLKSARSCFTEAMGTERDKARLSFI
                     ALHLGLCWLLLGAERDAREWTQLAHRTAVEAMKDILVEASKHQGLTQNRYLDPALTFFM
                     FFTSTATLGAGYLFWDRVLSKRTGTVMRRALGQMQALADYVDMLGEVRLRLGELPHDVA
                     RYELTHGVDERQSVARITIRKLINDREAIYFNGRETRKVTWNDQERSEVITRELI"
     gene            8945..9643
                     /locus_tag="BLU09_RS17055"
                     /old_locus_tag="SAMN04488504_105168"
     CDS             8945..9643
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011554167.1"
                     /locus_tag="BLU09_RS17055"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04488504_105168"
                     /product="response regulator transcription factor"
                     /protein_id="WP_090490600.1"
                     /transl_table=11
                     /translation="MAERPTVLVVDDDPHLREIVRFALEQGGFRVDEAADGRAALKQVD
                     RALPALIVLDIMMPELDGLAVCREVRRKHELPIVFLSSRDDEVDRILGLELGGDDYLTK
                     PFSPRELVARVKAVLRRARPAPVPEVEAPAARMQSRGPLRMDAERWRAWWQDTEVVLTV
                     TEFQLLATLLRVPGKVFTRDELMNRVYDDVVVSDRTIDSHVRRVRQKFASAGGDVIETV
                     HGLGYRLALP"
     gene            9612..11252
                     /locus_tag="BLU09_RS17060"
                     /old_locus_tag="SAMN04488504_105169"
     CDS             9612..11252
                     /GO_function="GO:0000156 - phosphorelay response regulator
                     activity [Evidence IEA]"
                     /GO_function="GO:0004673 - protein histidine kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0007165 - signal transduction [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1003: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013940774.1"
                     /locus_tag="BLU09_RS17060"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04488504_105169"
                     /product="HAMP domain-containing sensor histidine kinase"
                     /protein_id="WP_090490601.1"
                     /transl_table=11
                     /translation="MALAIGSPSPERRARPRLWLVFAAVGIAGFALTLAGLAFVRVYDN
                     QLIRQTESELIAQGAVVAEVFRERMRATVLEGAYGRERTAPWPFPIPDDTRLRPILPSL
                     RASDASLPPGDTPRPSRVPAEPLSQAAGLQLTPLLEQVRAATLAGIRVVDTEGVVVASS
                     SPALLWTTLADRTEVQRALRGEPASVLRRRVADPEDTPLASLSRDTGIRVTVALPVLEG
                     DRVWGAVVLTRTPMTFAKATYADRWNLTATGFVLLGAVALMSLAAAALVGRPVRALVKQ
                     TRAIAMSDPSGFEPMARPVVAELAELSESLAGMATALRDRNQYIRSFAANVSHEFKTPL
                     ASIQGAVELLRDSADAMSPEQRARFLANVDADARRLTRLVQRLLELARADSMTATPAQV
                     ELGPLLEGLALRARADGATDIHVTAPPTGLKVSLPQEVLDDVLWQLVTNARQHGGDTVR
                     VDLSVEQAPEADLVRVVVKDRGKGISESNRARIFDAFFTTARERGGTGLGLTIAQSMLR
                     AFHARLELLPSDTGTTFAVVAPVPRLQRK"
ORIGIN
        1 gaattccgaa cggttacaaa aatgtaggtc cgtataggcg gcggatgcta gccatcgcta
       61 aactggcttg tcaacgaacg caagatgacc cgcatacgca tcggacagcg ctggaaacgc
      121 gaacccgcgg cttccccgct cgattccatc gcactggaat tggacggggt ggaccttctg
      181 tccggggccg tggaggagtc tctagcagaa gtcgtcccct ccctggtgcg ctcagttgcg
      241 gcgctcgcgg gtggacgtca gaaactggcc caggtctccc tgcccgaggc ccacctggag
      301 ctggtgctcc gccgcatggg gccggaggtg gagctgctgg tggccaacct ctcccgccct
      361 gcccggctga tgcgccctcc cgtccgggtg gagctggagg aactggtgga ggcggtccga
      421 gaggccggcg agcgattcct cgccgacgtc acccgggcgg ggcccaaggc gctcgccacc
      481 accgtggggc aggccctcaa ggagccgctg aaaggcctga accggcccgc ccgtcctcct
      541 gacgaggcgc cggcccggcc cgccacccgg cgcgtggagc ccacggaagt cccaggcttc
      601 ggcttcgagg tccggaacgc cggggctccc atgagccgtg gcgccgcgcg gggaacggcc
      661 ggactgcttg cgcccctgct ggccgcgggc gaggtctggc tgtcgctgcc cggcaagccc
      721 gaggcctggc gcgtccccgg cccgccgttc ctgacgacgc tggagctgtc gcgactggcg
      781 gtggagctgg cgcgcacggt ggagctgggc gaaagccgct tcgagctggc ccccgcgggc
      841 gcgaagcctc cgctcctggt cgacctgaag tcgggccagg cgaaggcggg acgcaccggg
      901 acgcccttcc cgctcacggg caccgtgctc gccgccgccc tcttccacct gggcgagtcc
      961 ctggccgcgg ccttcgcgga agcggaccac gcgctggtgg ccaacccgta ccggatggag
     1021 ctggcggagc gctgccgcga gggcctttcg cacctgcgag gccccgtgca gccccccgag
     1081 gccaagggcg cggcccgcga gaagaaggcc cgggccacgg gccagggcac gtcacggccg
     1141 ttgaaggtcc ccggccgctt gcgccggctg cgcttcgcga agctgtggga gaagcgcggc
     1201 ctgccggacg cggaggaatc gcggctgctg ctgggccggc acggaccggt gtactgcgcg
     1261 ccgcacctgg cctccgcgtt ctcccgaaag gacggagaac tgctgtggaa acgcgccgcg
     1321 gcgttgggcg tggccgcgtc ggcggatggc cacgcggtgg cggcggacat cgcgcgcgtc
     1381 tacggcttca cgggccgggg cggtggcgcg cgctggctgc atgaccacga cggaatcccg
     1441 ctgggcccgc tgctgctgcg caaggacggc ctgctgctca ccttgtccga ggaccgcacc
     1501 gtcgtggcct tcgcggaggc cacgggccgc gaggtctggc gcctggcgcc gccgcgcacc
     1561 cagcgcagct ggctggccac ccagggacac cgcgcgctgg tgggcacgga ctcgggctac
     1621 ctctatgggc tcgacctgga ggacgggcag gtccgctacc gcatgcgcgc gcccatgccg
     1681 ttccacgggc ccccggtggc ctggggccgg cgcttcctgg ccatgctggg ccgcggctcg
     1741 cactgggccg tgctgctcgc ggacgcgcac accggcgaat ccgtgtggac gtatgagccg
     1801 gacctgtccc acctgtccgc gccgttgccc gtgggctcgc gggtgttcat cgccggagag
     1861 cgcgagcgcg aaggcatgct gctctgcctg gacgcgaagg gccggcgtct ctgggagcgc
     1921 ccgctcaacc tgggccctgg cccctttgcg ttggcgtccc tcccccgcgc ggtcgtggtg
     1981 acgagcgcct cgggcgccgc cacccgggtg gccgcatccg gaacggtgga ctggcgcgtg
     2041 ggcgccgcgg gcgagccgct catcagcgcg ctccccgccc ataccgcgcg cgacatcacg
     2101 ctggtgccgg gggagcgcgt ccgtgccgtg gacccccgcg gcgggcaggt gctcgcggag
     2161 gtccaggccg gcgtggggct cgtcgcgctc caggccgacg tgcgcctcaa cctctacttc
     2221 ctggacgatg ccggcacgct gtccgcgtac cggctcggct ctcacttcac ggtggtggag
     2281 taaccccgcg cgaaggccta gttggccgcg gccttcgacg ggtcgatctc ctcctcgggc
     2341 cgctcttcct gggtggcgcc ctcccaggtc tcgccagcgc cgagcttcca ttccgagggc
     2401 acgtccagct tccacacgta ggtggccgtc gcggtgccgc ccgacgccgc gctggaggag
     2461 aggttgatgg tcatctccac cttcgccacc tcgttcggga gcaggtccag gtcgtaatgg
     2521 cccagcacca tctgcggggg gaacgcccgg acgaagcgct ccgggtggtc aatcttcatg
     2581 gacgggtcgg cgccgcgcat ctcgcccagc agcttcccct tcgcgtccgt gagcttccac
     2641 accgtgtcga acgtggcgct ggtcatcatc ttcagcacct tgccgtcatc cttgagcacg
     2701 cgctgcgcgc cccacaccgc caactgcagg cggatctgcg gcttgcccag caccatcacc
     2761 acgtcggagg agatgatgtc caggcgcatg cccttgtccg tggccgacca caccgggcgg
     2821 taacggccct cgcgcaggct gtcgaacgtc ttgcgcgtgt actcgtagaa ggccttgcgg
     2881 tccttcgcgc ggtcatcctt cgcgccactc tcctcgcgct tctccagctc caggaggtag
     2941 tcgtcgaact tcgtgttccc cttgaaacgc gtcaggtgcg cgtccacctg atcgaagtag
     3001 ttcttgaaga agggcttcaa ctcatcacgg tagctggcct cgtccgggtt ggcgcgcatc
     3061 cagcccacgc gttcgaggta ctccgcgtga atccgttgct gatccgcatc ccgctgagcc
     3121 tccagcgcgc gaccgctcgc gctgcgatag ctcatgacgg cggccagcag cacacccgcg
     3181 acgatgacga tgactccgaa gtagcgcttc acgcggcagt ctcctgtgcc tttgtcccgg
     3241 cagtgatatg aaaaatcccc aacgtgatcc aggccaccgg gacccacctg ttcaccacgc
     3301 cccttccatt ggaggaagga gagctgctgg gcaatcccca ggtggcctgg gcggcctacg
     3361 gagaaccatc agacggcaaa gcggtggtgt tgctgcacga cctcgcgcat tcgcacctcg
     3421 cgttgggccc gccggaggac tcggcatacc agccctccgg ctggggacgc gccctggtgg
     3481 gggcgaacct cgcgttggac cccgccatca cccccgtctt ctctcccggg ttgctcggca
     3541 gccctttcgg cagcacgtcg cccgcgacgg tgaatcccgc gtcgggggaa cgctgggggc
     3601 tcgagctgcc gccgctcacg gtgcaggaca tggcgcgcgc cgtatcggcc acgctgcgcg
     3661 cacaggggct gacgaaggtg cgcgcgctgg tgggcgtggg cctgggcgcc catgtggcgc
     3721 tgcgactggc gtcactgttc cccgacctgg ccgagggagt ggtggccatc ggcgcggcgc
     3781 gcgcgctgcc cgaaggcgtg cgcgagaagc tgggcctgtc ctggcaggtg ctgcgcgcgg
     3841 acccggacta ccgggacggc ctctacgcgc tggacgcgcc gccgcgaaag acgatgcgca
     3901 agctgcgtct ggacttcctg aagctgctct gcgggcgtga gttcctggcc tccgcgtacc
     3961 cggcccccga agcggcccgc gccgcgctgg aggcggaagc ggacgccttc gcggacgcct
     4021 tcgacgccgt gtcctgggcg tcgctgtgct cggcgtacgc gggcagcgac gtgtcggacg
     4081 gcttctcgcg aatccgtgcg cgggtgctcc tggtgacggg gacgtcggat gccatggccc
     4141 cgatgaaccg ggtgcgtgac acctaccacc tgctgagcgc ggcgggcgtg agcgcccgtt
     4201 tcctcgagct gccggggccc ggggaccacg cggcactgct ccaggacgcg gagcggctcc
     4261 atggcccgct gagcgacttc ctgcggcggt gctgactagt cccgattcac ggcgccagag
     4321 agcttgccgc gaagcgcgcc caccagcatg ccgatggcaa tctcgttgtt gccgccgtgc
     4381 gggatgatga tgtccgcgaa gtgcttggac ggctccacga agcccatgtg catgggccgc
     4441 acgtggcgca ggtactggct caccacgtgg tcgaagtcgc ggccgcggtc cttgatgtcg
     4501 cgggtgaggc gccggaggat gcgaaggtcg tcgtccgcgt cgacgtagat cttcacgtcc
     4561 atctcatccc ggacctcctt catgtggagc accaggatgc cctcgatgag gatgatgtcg
     4621 ccggggtcca cgttcttcgt ctgcggcgtg cgcgacgaag tgacgaagtc gtagacgggc
     4681 ttctggatgg gatgcccgga cttcagcgct tgcaggtgct gaaccagcag ctccctgtcg
     4741 aaggcatccg ggtggtcgaa gttcacctca cgcctgtccg ccagcggaag gtccttcaag
     4801 tcccggtagt atgaatcctg atcgatgaag gccacgcggc aatcggccaa tgcctcgcgt
     4861 accttgcggg caacggtggt cttgccggac gcggtgccgc ccgcgattcc gacgacgagg
     4921 ggggacgcca tgtgggcgcg acgtatctta ccaggacgac cagcgcaagg gttcggtcca
     4981 atcccggaca attcttcccg ctatccctgg cggatcagcc ctcgcgccct cgccgcctcc
     5041 agcaacccag gggctacctc cgcctcggcc atgggccgca cagcgagcat tcccaggaat
     5101 tcacccaagg ccaggggcac cgacatcacg tccggtcctc ccgccctgcg ccgcgcgacg
     5161 aaggaccagg gccccgggcc gggcctgcgc gccacctggt tcagcgaatc caggccggac
     5221 agctccaacg tgccacacgc ccacgcacgg gccgtgaggt gccggcgcac ggctcgggcg
     5281 gaatggacca gctcggacag gtccacggga agcgacccga cccgcacgtc ctccatcaac
     5341 cccacctgcc ctggcgcggg ggcgggcacc cgccgcgtga acagcgacgg cagcagcatc
     5401 tccagcgtca gcgccgccga cgccccctca tccggtgact cgcgcaggcg gcgcatggcc
     5461 caggacgcga aggactgacc gggcgtccgc gccacggagt cgaagagctt ccggtactcc
     5521 ttcgagccgg tgaaggccgc cagcccctcc cgcgtgcccg cgagcaacaa ccgggtgagc
     5581 ggccaatcgc ggtccaggac ctccgcgacc acggccaggc ggaagtcctg gtccgccagc
     5641 gtgcccgctt cgtcctccac ggaggccgcg ggcgcggcgg cgtaacccgc gtcgaacaag
     5701 gcccagggct ggctgtcctc cgtgagtgga ggcacggccg cgacagccgc cggtacgcgc
     5761 cacgtcagcg gcggacgcgc tcccgcgggc accagttggc gcaggcggcg caaggacatc
     5821 cgggcgacct cgggcgggtg gccatccccc tcgaaggtga cggctcgcag cgatgggcag
     5881 cgcggaatca acgaggccag caggtcgaac agctcctcgc gcaccggctg cgtgtggtca
     5941 tccacgtaga agctgcgcgg cccccggtgc gtcaccacgc ctccggcgat gtgcagctcg
     6001 acgacctggt cgagcggaaa gccgtccagc cccgtctcca atggcagtcc cgcggagagc
     6061 tgatggctga gcaggtgccc caggtcgagc agcagcggcg ccccggtgcg cgcgtgcagc
     6121 ttcgccatga agtcgagcac atgccactgc ccgcgccgcg cgagcaccgc ggggttctcc
     6181 agcgcgagcg gcacggacag gtgttgctgg acctggagcg cgtgggacac gcacgcctcc
     6241 aggcccgctt cgttgaaggg cggcgtgaag tagaggtagc ccgggaaggg ctgcccatcc
     6301 acgtgccacc agcccacgtc gttgcccacc caggggctct ccacggcgcg cgcgtgggcg
     6361 tccaaatccc tcaaggcctg gacgggctcc agcgcgggcc cccagaggtt gaggtggacg
     6421 ggatggaaga gcaccgggac gtcctggcga cggcgccaca tctccgggaa cagcgaggcg
     6481 tgcgccttcg actcttccaa ggagagcggc gcactgtact ccacgtagtc gaagaggccc
     6541 ggtgactcgt ccagcaagcg gtagggctgc ggcacgtccg ccacgctcag gttgctgctc
     6601 aaccccaggc cccgccaggg cagtgtccac gtctcggaaa ccgcatgcgt catgcgctca
     6661 acgtagacgc gccccgcgtc caccgccacc cgcgactgcc gggcagtggc gcgatgaacg
     6721 cacccgaggt cgggtatgct cgccgattcc cctcacccca ggagccgcga tgcccgcccc
     6781 ctcacgcgtc gagatagatg agtccaacgc gcagtaccgt ggagcctgga ggcgcttcgc
     6841 cctgggcagc aagtcgggtg aagtggtgga gcgacccgag gtctacatca ccgcctgcca
     6901 cgtcgcctgg tcgatgatga actccgcctt cctgcgcgcg cccgtcgaaa cggaacaagc
     6961 gctggcggcc gcggcggcct cggcggcgcg ctacttctcc gccggtagac atggctggag
     7021 cttcgtcgtc tgcgacgact ggctggcccc ctccatgcgc gacaacgcgc catccatcct
     7081 cgcctggtac gggctcaagt ccgagatgga cgtcaccggc atggtggcgg accggctggc
     7141 gccctccatt cacccacggc ctccgttcac catgcgtccc gtcacggata cgtggggccg
     7201 gcaggccgtg gccgacatca acgccaacgt ctacgacgtc ccccgccact tcggccgtga
     7261 agccttcgac gaggacacgc tctacacccc ggactgccag ggcttcgtgg cgtgccgcga
     7321 cgaagaggcc gcggccagca cggtggtgct gcgcgtggat gccgccgcct acgtcgccct
     7381 ggtggcgacc cagccgcaat accgccggca aggtgccgca gaggccgtga tgcgacatgc
     7441 gctggccaag gcccatcagg actggggcac cgagcgcacc gtcctccacg ccacgagcga
     7501 aggcgagcct gtctataccc gcatgggcta ccggccggtg acgcgcttcc gcatgtacat
     7561 ggcgcctcca ccaggccagg gctgagccac acacggtgct cggcacgggg gagtaaaaac
     7621 agactcacgc catttcgagc gagtgactgg ctttttctac cgagcttgaa agccagccgc
     7681 tccgtcgcat tgaagaatgc cgctctcgca tgaactgcgg cccacattct tcgatggcgg
     7741 ggaggttgtg gcagactgat ccgtgagggg gcttgctgca cgtcttgcat cgcccagcca
     7801 cacggagtcc gcacatggcc aagtgggatg atctcgtcct ggcgattcca ccgcacgcgg
     7861 gcggcaggtc tcaggctccc gccgcggtca cgctgctgga gacactcctc ggccttcacg
     7921 aagcacagct caccctcctt cgcgggttgc atcgcgacgt ccggccgctg caggaaggtc
     7981 ccttcctggc cgggcggctc cacctggacg ccgtgcgtgc ccctcaggcc acccgcgacg
     8041 aacagctgga gcggctgaag tccgcgcgga gctgcttcac ggaagccatg ggcaccgagc
     8101 gcgacaaggc gcggctgtcg ttcatcgccc tgcacctggg cctctgctgg ctgctgctgg
     8161 gcgcggagcg ggatgcgcgg gagtggacgc aactggccca ccgcacggcc gtggaggcca
     8221 tgaaggacat cctggtggaa gcctcgaagc accagggcct cacccagaac cggtacctgg
     8281 atccggcgct caccttcttc atgttcttca ccagcacggc cacgctgggc gcgggctacc
     8341 tcttctggga ccgggtgctc agcaagcgca cgggcacggt gatgcggcgc gcgctggggc
     8401 agatgcaggc gctggcggac tacgtggaca tgctgggcga ggtccgcctc cgcctgggcg
     8461 agctccccca tgacgtcgcc cgatacgagc tgacccacgg cgtggacgaa cggcagtccg
     8521 tcgcccgcat caccatccgg aagctcatca acgaccggga agccatctac ttcaacggcc
     8581 gggagacccg gaaggtcacc tggaatgacc aggaacgctc cgaggtcatc acccgcgagc
     8641 tgatctgacg ccgggcgctg tcaccgtccc gtcaaaacct gttttcagga ttgcctcggc
     8701 gatacgtcag accggcccgc catagtagcg gcacttcctt gatgggggcg aaggtgacgg
     8761 cgcagacgat gctcgtgttc attccagtga ttctcctact cgccgcggcg gttgcgattc
     8821 cgcggccccg ccggcgctca cgccggtagt cgtagtcacg gccgggggtg cgccccggcc
     8881 gtctccctgg cccgggcggg tgtagagtgc ggcagtcgtc gcaaccctcc cctcccgagc
     8941 agccgtggcc gaacgtccca cagtcctggt cgtcgacgat gatcctcacc tgagggaaat
     9001 cgtccgcttc gcgctggagc agggaggctt ccgggtggat gaggccgccg atggccgcgc
     9061 cgccctgaag caggtcgacc gcgccctccc agcgctcatc gtcctggaca tcatgatgcc
     9121 ggagctggac gggctggccg tgtgccgtga ggtccggcgc aagcacgagc tgcccatcgt
     9181 cttcctctcc tcgcgggatg acgaggtcga ccgcatcctg ggcctggagc tgggcggcga
     9241 cgactacctc accaagccct tcagcccgcg cgagctcgtg gcgcgcgtga aggcggtgct
     9301 ccggcgcgca cggcccgcgc cggtcccgga ggtcgaagcg cccgccgcgc ggatgcagtc
     9361 ccgagggccg ctccgcatgg acgcggagcg ctggcgcgcg tggtggcagg acacggaagt
     9421 ggtgctcacg gtgacggagt tccagctcct ggccacgctg ctccgagtcc ccggcaaggt
     9481 cttcacccgg gatgagctga tgaaccgcgt ctacgacgac gtggtggtca gcgaccggac
     9541 catcgacagc cacgtgcgcc gggtccggca gaagttcgcg agcgcgggcg gagacgtcat
     9601 cgagacggtg catggccttg gctatcggct cgccctcccc tgagcgccgc gcgcgcccgc
     9661 gcttgtggct ggtgttcgcc gccgtgggca tcgcggggtt cgccctcacg cttgcggggc
     9721 tcgccttcgt gcgcgtctac gacaaccagc tcatccgcca gacggagtcg gagctgattg
     9781 cccagggcgc ggtggtcgcg gaggtcttcc gcgagcggat gcgcgccacc gtgctagagg
     9841 gcgcatacgg ccgcgagcgc accgcgccct ggcccttccc cattcccgac gacacgcgcc
     9901 tgcgccccat ccttccgtca ctcagggcct cggatgcatc cctgccgccg ggcgacacgc
     9961 ctcggccttc gcgcgttccc gcggagccgc tgtcacaggc ggccggactg caactgacgc
    10021 cgctgctcga acaggtgcgt gcggcgaccc tggccggcat ccgcgtggtg gacaccgaag
    10081 gcgtggtcgt ggccagcagc agccccgccc tcctgtggac gacgctggcg gaccgcacgg
    10141 aggtccagcg ggccctgcgc ggagaacccg ccagcgtgct gcgccgccgc gtcgccgatc
    10201 ccgaggacac cccgctggcg tcgctcagcc gtgacaccgg catccgcgtc acggtggcgc
    10261 tgcccgtgct ggaaggcgat cgcgtctggg gcgcggtggt gctgacacgc acgcccatga
    10321 cgttcgccaa ggcgacgtac gcggaccggt ggaacctcac ggccaccggc ttcgtgttgc
    10381 tcggcgcggt ggcgctgatg tcgctggccg ccgccgcgct ggtgggccgg ccggtgcgcg
    10441 cgctggtgaa gcagacgcgc gccatcgcca tgagcgaccc ttcgggcttc gagcccatgg
    10501 cgcgccccgt ggtggccgag ctggccgagc tctccgagtc cctggccggc atggccaccg
    10561 cgttgcgaga caggaaccag tacatccgct ccttcgcggc caacgtgtca cacgagttca
    10621 agacgccgct ggcctccatc caaggcgctg tggagctgct gcgcgacagc gccgacgcga
    10681 tgtcccccga gcagcgcgcg cggttcctcg ccaacgtgga cgcggatgcc cgcaggctca
    10741 cccgactggt gcagcgcctg ctggagctgg cccgggcgga ctccatgacg gccacgcccg
    10801 cgcaggtgga gctgggcccg ctgttggagg ggctcgccct ccgcgcccgc gctgacggtg
    10861 ccacggacat ccatgtgacg gcaccaccca cgggcctgaa ggtgagcctc ccgcaggagg
    10921 tgctcgacga cgtgctgtgg cagctcgtca ccaatgcccg ccagcacggt ggcgacaccg
    10981 tccgcgtgga cctgtcggtg gagcaggccc cggaggcgga cctcgtgcgc gtggtggtga
    11041 aggaccgagg caagggcatc tccgagtcca accgtgcgcg catcttcgac gccttcttca
    11101 ccaccgcccg cgagcgaggc ggcacgggcc tgggcctgac gattgcccag tccatgctgc
    11161 gcgccttcca cgcgaggttg gagctgcttc cttccgacac gggcaccacc ttcgcggtgg
    11221 tggcgcccgt gccccggctt caacggaagt agctgtcgga gatgtccacg gagtagccca
    11281 gctccagcgt gggcgaggac gcggccacca ggaactggcg gaagtgcagc gcctttccgg
    11341 gcaggcccga cgcccccgcg gccacggctt ccgtcgactc gtactgctcc aggctgccgc
    11401 cctcgcggcg gtagttgaac accgcgggga agtgcgcgcg tgcgcggagc tccgccaccg
    11461 gccaggagac tcgcggcaac gccagcttca accggccgga gaggtggaac acgcccagct
    11521 ctcgcgacag caccacctcc agcgtcccgc ccgtctctcc cagccgcgcc ggagcggcct
    11581 tcaacgccag ggtgccgttc tccgactcca cggggacggg aatggcattc agggtgacgc
    11641 gctccagccg gtg
//
