LOCUS       NZ_FMZZ01000002        10804 bp    DNA     linear   CON 09-DEC-2024
DEFINITION  Actinokineospora iranica strain IBRC-M 10403, whole genome shotgun
            sequence.
ACCESSION   NZ_FMZZ01000002
VERSION     NZ_FMZZ01000002.1
KEYWORDS    WGS; RefSeq.
SOURCE      Actinokineospora iranica
  ORGANISM  Actinokineospora iranica
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Pseudonocardiales; Pseudonocardiaceae; Actinokineospora.
REFERENCE   1
  AUTHORS   Varghese,N. and Submissions,S.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-OCT-2016) DOE - JOINT GENOME INSTITUTE, LBNL, 2800
            Mitchell Drive, Walnut Creek, CA 94598, 94598, USA
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_900101685.1-RS_2024_12_09
            Annotation Date                   :: 12/09/2024 15:26:45
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.9
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,202
            CDSs (total)                      :: 6,139
            Genes (coding)                    :: 6,038
            CDSs (with protein)               :: 6,038
            Genes (RNA)                       :: 63
            rRNAs                             :: 3, 4, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 3 (5S)
            partial rRNAs                     :: 4, 4 (16S, 23S)
            tRNAs                             :: 49
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 103
            CDSs (without protein)            :: 101
            Pseudo Genes (ambiguous residues) :: 0 of 103
            Pseudo Genes (frameshifted)       :: 25 of 103
            Pseudo Genes (incomplete)         :: 89 of 103
            Pseudo Genes (internal stop)      :: 7 of 103
            Pseudo Genes (multiple problems)  :: 18 of 103
            CRISPR Arrays                     :: 3
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 18:38:36
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 139168
            Orig. end                         :: 149972
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            FMZZ01000002.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..10804
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="2"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..10804
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10804
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:5804](+)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..5804
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     misc_feature    270..280
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 18.59"
                     /tool="antismash"
     misc_feature    565..580
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: medium, score: 24.81"
                     /tool="antismash"
     gene            complement(616..1668)
                     /locus_tag="BLS56_RS05935"
                     /old_locus_tag="SAMN05216174_102127"
     CDS             complement(616..1668)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018684635.1"
                     /locus_tag="BLS56_RS05935"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216174_102127"
                     /product="DNA polymerase domain-containing protein"
                     /protein_id="WP_091448920.1"
                     /transl_table=11
                     /translation="MAPAVEIEVEGPHGPRAVRVSNPDKPYFADIGVTKRQIVEYFLSV
                     GDGVLGALRERPTTLERWPGGVFEGARLSTRQDNSGDAFYQKRIPKGAPDYVETARITF
                     PSGRPADEVCPTELAVVAWAANLGTLTFHPWPVRRADVDHPDQLRIDLDPQPGTDFSDA
                     VTVAFQVRELLASMDIQAFPKTSGGRGVHLYVPIEPRWTFTEARRALIALGREMERRLP
                     ERVTMSWWKEERGARVFIDYNQMARDRTIASAYSIRPTPRALVSAPLTWDELPDVHPED
                     FSILTMPARFAEVGDLHAPVAEHAFSLRPLIDLADRDERDRGLGDLPYPPDYPKMPGEP
                     KRVQPSKARD"
     misc_feature    1625..1639
                     /note="TFBS match to OsdR, Development and stress
                     management regulator, confidence: weak, score: 24.27"
                     /tool="antismash"
     misc_feature    1735..1746
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 15.23"
                     /tool="antismash"
     gene            1777..3027
                     /gene="hisS"
                     /locus_tag="BLS56_RS05940"
                     /old_locus_tag="SAMN05216174_102128"
     CDS             1777..3027
                     /EC_number="6.1.1.21"
                     /GO_component="GO:0005737 - cytoplasm [Evidence IEA]"
                     /GO_function="GO:0004821 - histidine-tRNA ligase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0006427 - histidyl-tRNA aminoacylation
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="hisS"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018684636.1"
                     /locus_tag="BLS56_RS05940"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216174_102128"
                     /product="histidine--tRNA ligase"
                     /protein_id="WP_228771458.1"
                     /transl_table=11
                     /translation="MDNSPARGTRDLLPATVAVRDHVLARITEVYHRYGYQRIETPALE
                     NIERLQGGQGGENEKLIYRVLRRGLDEVVAAETRLDDLVDLGLRYDLTVPLTRFYGNNQ
                     ASLPQPFRSFQFGPVWRAERPQKGRYRQFYQCDIDMLGEESVLAEVELIEATTEALAAA
                     GLDGATVRVSDRRFLSALAQAAGLPEQAWTGLFITLDKLDKIGWEGVRAELPGRGLDTA
                     QIDRLQETITGLRGVDPAKLGDRLAEAVPDLPDEVVADLAGTADALRALDGLDWEFDPT
                     LVRGMGYYTGQIFEITHPAAAGSVAGGGRYDRLIGRSLGRDVPACGFSIGFERIVDLIE
                     GAGSRAAVAVLYEADVPLPTVVGSARELRRDGRTVSPIRRRGKLGAQLGRLTEWGFTSV
                     VHLRADGPTEERPLESR"
     gene            3064..3402
                     /locus_tag="BLS56_RS05945"
                     /old_locus_tag="SAMN05216174_102129"
     CDS             3064..3402
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004560769.1"
                     /locus_tag="BLS56_RS05945"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216174_102129"
                     /product="hypothetical protein"
                     /protein_id="WP_091448922.1"
                     /transl_table=11
                     /translation="MVGTGFRGTSDDDPRPGDHARRKDRFSDDLIGLDPADPEVREFAE
                     HLDRVERVRPSYTVEGYLGQVSDFADSANRLGGHYRLTAGIVAALILLGVVVAAWDALV
                     FIVSVLLG"
     gene            3471..3938
                     /gene="msrB"
                     /locus_tag="BLS56_RS05950"
                     /old_locus_tag="SAMN05216174_102130"
     CDS             3471..3938
                     /EC_number="1.8.4.12"
                     /GO_function="GO:0033743 - peptide-methionine (R)-S-oxide
                     reductase activity [Evidence IEA]"
                     /GO_process="GO:0006979 - response to oxidative stress
                     [Evidence IEA]"
                     /GO_process="GO:0030091 - protein repair [Evidence IEA]"
                     /codon_start=1
                     /gene="msrB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018684638.1"
                     /locus_tag="BLS56_RS05950"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216174_102130"
                     /product="peptide-methionine (R)-S-oxide reductase MsrB"
                     /protein_id="WP_091448923.1"
                     /transl_table=11
                     /translation="MKPVVGATPRVVKSEQEWRAELDPREYAVLRAAGTEPAWTGEYTE
                     TKTAGVYRCRACGAELFRSDTKFESHCGWPSFFSPLAGESVVLREDRTHGMVRTEVLCA
                     SCHSHLGHVFEGEGYPTPTDQRYCINSISLTLVPDGDTSSSDTPGGDIAGA"
     misc_feature    3995..4015
                     /note="TFBS match to MntR, Manganese transport regulator,
                     confidence: weak, score: 22.01"
                     /tool="antismash"
     misc_feature    4015..4030
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: medium, score: 16.67"
                     /tool="antismash"
     gene            4068..4979
                     /locus_tag="BLS56_RS05955"
                     /old_locus_tag="SAMN05216174_102131"
     CDS             4068..4979
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:TIGR04222.1"
                     /locus_tag="BLS56_RS05955"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216174_102131"
                     /product="TIGR04222 domain-containing membrane protein"
                     /protein_id="WP_091448924.1"
                     /transl_table=11
                     /translation="MNEPWGISGPEFLRLYLVAAGFAVLIALAVRIMARTASATERTPG
                     QLTLDELAYLAGGTRRVVETAVARLLDEGKLRISRTGAVGVVDGARGGGAVDQAVLADA
                     KRYGHRTLRLLVDKVGQDAAVTRIGADLTRKGLLVDKGMSRARLSAAPLAVLFAVGAAR
                     WVNGLSEGRPIGWLTLALLGTAVVAAVLFRRPVPSRTYQGARMLAEARRGRATASSRTI
                     GAHAPDYALGTAAGLVVFGGLATYPDAEIAAALETQRAATGYSASSSGTSSSSSCGGGS
                     GSSCSSGGGGGGCGGGGGGCGG"
     gene            5001..5804
                     /locus_tag="BLS56_RS05960"
                     /old_locus_tag="SAMN05216174_102132"
     CDS             5001..5804
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: DUF692"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013224517.1"
                     /locus_tag="BLS56_RS05960"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216174_102132"
                     /product="DUF692 domain-containing protein"
                     /protein_id="WP_091449265.1"
                     /sec_met_domain="DUF692 (E-value: 1.9e-84, bitscore: 278.0,
                     seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGELGVGIGWRSEIDLTVERLPGVDFVEVVAENLHRDHLPESLRL
                     LRGRGVPVLPHAVSLSLGGADPLDRDRVEHLAAVAELLAAPVASDHICFVRAGGLDSGH
                     LMPVPRTRDALDVLTANVKAAQADLGTPLALENIAALLEWPDAELTEAAFLTELVERTG
                     CLLLIDVANMWANARNLGQDPVDLLDGLPLERIAYVHVAGGVERDGVYHDTHAHPVPDG
                     VLDLLGELCARVRPPGVLLERDDRYPADAELAAELTAIRGVLAGT"
     gene            5801..6232
                     /locus_tag="BLS56_RS05965"
                     /old_locus_tag="SAMN05216174_102133"
     CDS             5801..6232
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015800396.1"
                     /locus_tag="BLS56_RS05965"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216174_102133"
                     /product="hypothetical protein"
                     /protein_id="WP_139190535.1"
                     /transl_table=11
                     /translation="MTSGDMTSGHMPHGDADRRARLAARQADLLRALLADGPPPAGFDP
                     AAVAVEAAALLAKRRRVVAHLAPDVAGDLGERFAPLFDEYARANPRRTGSRAREDAAAF
                     ERWLTDRGNLAEPRRPWWRLGRPGDRARVVSRAGATPPG"
     gene            complement(6318..7082)
                     /locus_tag="BLS56_RS05970"
                     /old_locus_tag="SAMN05216174_102134"
     CDS             complement(6318..7082)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020423171.1"
                     /locus_tag="BLS56_RS05970"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216174_102134"
                     /product="VOC family protein"
                     /protein_id="WP_091448926.1"
                     /transl_table=11
                     /translation="MVTRNTAWPAGTPCWVDLGTDVAQAAEFYSGLFGWRVDIGGEEVG
                     GYANCFLGDEFVAGLGPLQEGQTSAWTTYLSSTDVDADAAKITAAGGQIVLPPLQVSEF
                     GRMVVAIDTAGAGFGLWEAGKHTGVTLANEPGSLVWNEQMSADLAASKEFYAKVFGYAY
                     EDMEGAPGGYATLNVPGGEQPVGGIGGGLDAGTPAYWGVYFQVADADATLEKVKELGGS
                     VLDGAVDTPFGRMATVADDQGAQFKVMGVPAS"
     gene            7273..7773
                     /locus_tag="BLS56_RS05975"
                     /old_locus_tag="SAMN05216174_102135"
     CDS             7273..7773
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="BLS56_RS05975"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="SAMN05216174_102135"
                     /product="hypothetical protein"
                     /protein_id="WP_091448927.1"
                     /transl_table=11
                     /translation="MRLGVKGTALFALCLSALLGCGSSPGAGDPPCTAIGSPAAISLDI
                     SPETAPAISAATPPPTGQLTACWGGECRTAQLDLRAATSAGATTCVDENCSAQMTPTGG
                     LAGFVELPDLPKDTPVAVTLALGGAEHRVEVVPRATFPNGPECGEGGPQARLTLNQGGL
                     SAG"
     misc_feature    7958..7974
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 15.53"
                     /tool="antismash"
     misc_feature    complement(8058..8072)
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 18.6"
                     /tool="antismash"
     misc_feature    8158..8172
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 16.93"
                     /tool="antismash"
     misc_feature    complement(9424..9439)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 19.51"
                     /tool="antismash"
     misc_feature    10104..10118
                     /note="TFBS match to OsdR, Development and stress
                     management regulator, confidence: medium, score: 24.85"
                     /tool="antismash"
ORIGIN
        1 cgcgcgtcca acgtcaacac atccaccgag tagccaaggt cgttcaactc agcgatcgcc
       61 gccgccaagt cctcaccgcc atggctggtc gccaagccga ccacgttctc cagggtgacg
      121 acctcgggtc gggcatcttc gcccaactca cgcaagaccc gcgtgaattg gtagaaggtc
      181 gatgagcggg caccctgcat cccggctcgc gctcccgcca acgacacgtc cacgcacggc
      241 gatgaagccc aggccaacgc gatgtccgct ggcatgtcac tcccccgcac gtgggtgaca
      301 tctcccaaca cgaacgtgtg cgactcctcc ggatctttga agttgcctgc atacatgtcc
      361 cgcttcgcag gctcgatgtc attcgaccag gcgacgcgga acccggcctg ttgcagtccc
      421 aaccgcgcca agccgatccc cgcgaagaac tcgacagcca taggctccag tggcaaggcg
      481 gtttgctcgc gcacagcggc tagcttcggc acggttcgca ccgtacgaaa cctaccgggc
      541 agagtgtggg acgctggcgg tgggtcgcac ggctgttcga gccctatccc cgctgcactg
      601 accgagtcgc gcttactagt ccctggcctt cgacggctgg acgcgcttgg gctcgccggg
      661 catcttcggg tagtcgggcg gatacggaag gtcacccaga ccgcggtccc gttcgtcccg
      721 gtcggccaga tcgatcaagg gccgcaagga gaaggcgtgc tcggcgacgg gcgcgtgcag
      781 gtcgcccact tcggcgaagc gggcgggcat ggtcaggatg gagaagtcct ccgggtggac
      841 gtcgggcagc tcgtcccagg tcagcggggc cgagacgagg gcgcgcgggg tggggcggat
      901 ggagtaggcc gaggcgatgg tgcggtcgcg ggccatctgg ttgtagtcga tgaacacccg
      961 ggcgccgcgt tcctccttcc accagctcat ggtcacccgc tcgggcagcc gccgctccat
     1021 ctcgcggcca agggcgatca gggcgcggcg ggcctcggtg aacgtccagc gcggctcgat
     1081 cgggacgtag aggtgcacgc cgcggccgcc ggaggtcttg gggaacgcct ggatgtccat
     1141 cgacgcgagc agttcgcgca cctggaacgc cacggtgacc gcgtcggaga agtcggtgcc
     1201 gggctgcggg tcgagatcga tgcgcagctg gtcggggtgg tcgacgtcgg cgcggcggac
     1261 cggccagggg tggaaggtga gggtgcccag gttcgccgcc caggccacga ccgccaactc
     1321 ggtcgggcac acctcgtcgg cggggcggcc gctggggaag gtgatgcggg cggtctcgac
     1381 gtagtccggc gcgcccttgg ggatgcgctt ctggtaaaat gcgtcgccgc tgttgtcttg
     1441 gcgggtggac agccgcgcgc cctcgaaaac gccgccgggc cagcgttcca gggtcgtcgg
     1501 gcgctcgcgc agcgcgccga ggacgccgtc gccgacgctg aggaagtact ccacgatctg
     1561 gcgtttcgtg acaccgatat cggcgaagta gggcttgtcc ggattggaca ctcgcactgc
     1621 ccgcgggccg tgcggcccct cgacctcgat ctccaccgct ggcgccattg gcccagcgta
     1681 cggccggtgg ggaacagacg cgcgcgcttt ggtgacctcc cggtagcgtt gaccgcaacc
     1741 gttaaccgtc atctgcgagg aacccgaccg gtgaagatgg acaacagccc cgcccggggc
     1801 acccgtgacc tgctgcccgc gaccgtggcc gtgcgcgacc acgtgctggc ccggatcacc
     1861 gaggtctacc accggtacgg ctaccagcgc atcgagacgc ccgcgctgga gaacatcgag
     1921 cgcctgcagg gcggccaggg cggcgagaac gagaagctga tctaccgggt gctgcgccgc
     1981 ggacttgacg aggtcgtcgc cgccgagacg cggctggacg acctggtgga cctggggctg
     2041 cgctacgacc tgaccgtgcc gctgacccgg ttctacggca acaaccaggc gagcctgccg
     2101 cagccgttcc ggtcgttcca gttcgggccg gtgtggcggg ccgagcggcc gcagaagggc
     2161 cgctaccggc agttctacca gtgcgacatc gacatgctcg gcgaggagag cgtgctggcc
     2221 gaggtcgagc tgatcgaggc caccaccgag gcgctggccg ccgccgggct cgacggcgcg
     2281 accgttcgcg tctccgaccg gcggttcctg tccgcgctgg cccaggccgc ggggctgccc
     2341 gagcaggcgt ggaccgggct gttcatcacc ctggacaagc tcgacaagat cggctgggag
     2401 ggcgtgcgcg ccgaactgcc cggccggggg ctggacaccg cccagatcga ccggctccag
     2461 gagaccatca ccggcctgcg cggcgtcgac ccggccaagc tgggcgaccg gctcgccgag
     2521 gccgtgccgg acctgcccga cgaggtcgtc gccgacctgg cgggcaccgc ggacgcgctg
     2581 cgcgcgctcg acgggctgga ctgggagttc gacccgaccc tggtgcgcgg catgggctac
     2641 tacaccggcc agatcttcga gatcacccac ccggcggcgg ccgggtcggt cgcggggggc
     2701 gggcgctacg accggctcat cggccgctcg ctgggccgcg acgtgcccgc gtgcgggttc
     2761 tccatcggct tcgagcgcat tgtcgacctg atcgagggcg ccgggagccg cgcggcggtc
     2821 gcggtgctct acgaggccga cgtgccgctc cccacggtcg tcggcagcgc ccgcgagctg
     2881 cgccgggacg gccggacggt ctcgcccatc cgcaggcgcg ggaagctggg cgcgcaactg
     2941 ggcaggctca ccgagtgggg cttcacctcg gtggtgcacc tgcgcgccga cggcccgacc
     3001 gaggagcgtc cgctggaatc tcgctgattc ctcttaccct gcccggcaag ctaccgtgga
     3061 ggcatggtcg ggacaggttt ccgcgggacg tccgacgatg acccgcgccc gggtgaccac
     3121 gccaggcgga aggaccgttt ttccgacgac ctgatcggcc tcgacccggc cgaccccgag
     3181 gtgcgggagt tcgccgagca cctcgaccgg gtggaacggg tgcggccgag ctacaccgtc
     3241 gagggctacc tgggccaggt cagcgacttc gccgactcgg cgaaccggct cggcggccac
     3301 taccggctca ccgcgggcat agtcgctgcc ctgatcttgt tgggtgtggt ggtggccgcg
     3361 tgggacgccc tggtgttcat cgtgagcgtc ctgctcgggt aagcacccgg cggcacggcg
     3421 cggaaacgag gcactgggga gaagagagag ctcgaatgaa gccagccgga atgaagccag
     3481 tggtgggcgc gacgccgcgc gtggtcaagt ccgagcagga gtggcgcgcc gaactcgacc
     3541 cgcgcgagta cgccgtgctc cgcgcggcgg gcaccgagcc cgcctggacc ggcgagtaca
     3601 ccgagaccaa gaccgccggg gtgtaccggt gccgcgcgtg cggggccgag ctgttccgca
     3661 gcgacaccaa gttcgagtcg cactgcgggt ggccgtcgtt cttctcgccg ctggcaggcg
     3721 agagcgtcgt gctgcgcgag gaccgcacgc acgggatggt ccgcacggag gtgctgtgcg
     3781 cgagctgcca cagccacctc gggcacgtct tcgagggcga gggctacccg acgccgaccg
     3841 accagcggta ctgcatcaac agcatctcgc tcaccctggt ccccgacggt gacacctcta
     3901 gcagcgacac ccccggcgga gacatcgctg gggcctgacc gcccctacct caaattcacc
     3961 tcaagcagcc ctaagtcctg cccacgggtt ccctaaatct tgctcaagct ctcttgtgcg
     4021 cgcgctcaca gcgcatcgag catggtgccc tcacaagggg gatcgacatg aacgaaccgt
     4081 ggggaatcag cgggccggag ttcctccggc tgtacctggt ggcggcgggg ttcgcggtgc
     4141 tcatcgcgct cgcggtccgg atcatggcgc gcacggcgtc cgcgacggag cggacgcccg
     4201 gtcagctcac gcttgacgag ctggcgtacc tggcgggcgg cacccggcgc gtggtggaga
     4261 cggcggtcgc cagactgctg gacgagggga agctgcgcat cagccgcacg ggggcggtgg
     4321 gggtggtcga cggcgcgcgc gggggtggcg ccgtcgacca ggccgtgctc gcggatgcca
     4381 agcggtacgg gcaccgcacg ctgcgcctgc ttgtcgacaa ggtcggtcag gacgccgccg
     4441 tcaccaggat cggcgcggac ctgacccgca aggggttgct ggtcgacaag gggatgtcgc
     4501 gggcgcggct gtccgcggcg ccgctcgccg tgctcttcgc ggtgggcgcg gcgcggtggg
     4561 tcaacgggct ttcggagggc cgcccgatcg ggtggctgac cctggccctg ctcgggacgg
     4621 cggtggtcgc ggcggtgctg ttccggcggc cggtgccgtc gcggacctac cagggcgcgc
     4681 ggatgctggc cgaggcgcgc cgcgggcggg ccacggcgag cagccggacg atcggggcgc
     4741 acgccccgga ctacgcgctc ggcaccgcgg ccgggctggt ggtgttcggc gggctggcca
     4801 cctatccgga cgccgagatc gccgcggcgc tggagacgca gcgggcggcg acggggtact
     4861 cggcgtcgtc cagcggcacg tccagctcgt cgagctgcgg cggcggcagc gggtcgtcct
     4921 gtagcagcgg gggcggcggg ggtggctgcg gcggaggcgg cgggggctgc ggcggctgac
     4981 cgagggggga aatggacggc atgggtgagc tcggggtggg catcggctgg cggtcggaga
     5041 tcgatctgac cgtcgagcgg ctgccgggcg tcgacttcgt ggaggtcgtt gcggagaacc
     5101 tgcaccgcga ccacctgccg gagtcgctgc ggctcctgcg gggtcgaggg gtccccgttc
     5161 tcccccatgc cgtctccctc tccctgggcg gggccgaccc gctcgaccgg gaccgggtcg
     5221 agcacctggc cgcggtcgcc gaactgctgg ccgccccggt ggccagcgac cacatctgct
     5281 tcgtccgggc gggcgggctg gactccgggc acctgatgcc ggtgccgcgc acccgcgacg
     5341 cgctcgacgt gctcaccgcc aacgtgaagg cggcgcaggc ggacctgggg acgccgctgg
     5401 cgctggagaa catcgccgcg ctgctggagt ggccggacgc ggagctgacc gaggcggcgt
     5461 tcctgaccga gctggtcgag cgcaccggct gcctgctgct catcgacgtg gccaatatgt
     5521 gggccaacgc ccgcaacctg ggccaggacc cggtcgacct gctcgacggg ctgccgttgg
     5581 agcggatcgc gtacgtgcac gtcgccggtg gcgtcgagcg cgacggggtg taccacgaca
     5641 cgcacgccca cccggtgccc gacggcgtgc tcgacctgct gggcgagctg tgcgcgcggg
     5701 tccgcccgcc gggggtgctg ctggagcgcg acgaccgcta tcccgcggac gccgagctgg
     5761 ccgccgagct gaccgcgatc cgcggcgtcc tggcgggaac atgaccagcg gggacatgac
     5821 cagcgggcac atgccccacg gggacgcgga ccggcgggcg cggctggccg cccggcaggc
     5881 cgacctgctg cgcgcgctgc tcgccgacgg cccaccgccc gcgggcttcg acccggcggc
     5941 ggtggcggtg gaggccgcgg ccctgctggc gaaacggcgc cgggtggtcg cgcacctggc
     6001 cccggacgtg gcgggcgacc tgggcgagcg gttcgcgccg ctgttcgacg agtacgcgcg
     6061 ggcgaacccg cgccggacgg gatcacgggc tcgcgaggac gccgcggcgt tcgagcggtg
     6121 gttgaccgat cggggcaacc tggccgagcc gaggcgccct tggtggcgac tgggcaggcc
     6181 aggggatcgg gcccgggtgg tgtcgcgcgc aggcgcgaca ccacccggat agacccaccc
     6241 ggatagaccc acccggatag acccacccgg atagacccgc ccggctggcc ccgctcggca
     6301 gccgcagcgc cccgagatca gctcgcgggc acgcccatga ccttgaactg ggcgccctgg
     6361 tcgtcggcga cggtcgccat gcggccgaag ggggtgtcga ccgcgccatc gaggaccgac
     6421 ccgcccaact ccttgacctt ctccagggtc gcgtcggcgt cggcgacctg gaagtagacg
     6481 ccccagtatg cgggcgtgcc cgcgtccagc ccgccgccga tgccgccgac cggctgctcg
     6541 ccgccgggca cgttcagtgt ggcgtagccc ccgggggcgc cctccatgtc ctcgtaggcg
     6601 tacccgaaga ccttggcgta gaactccttg cttgcggcga ggtcggcgct catctgctcg
     6661 ttccagacca gcgagcccgg ctcgttggcc agggtgacgc cggtgtgctt gcccgcctcc
     6721 cagagcccga agcccgcgcc cgcggtgtcg atggcgacga ccatgcggcc gaactcgctc
     6781 acctgcagcg gcggcaggac gatctgcccg cccgccgcgg tgatcttggc cgcgtccgcg
     6841 tcgacgtcgg tgctggacag gtaggtggtc cacgccgagg tctggccctc ttgcagcggt
     6901 ccgaggcccg cgacgaactc gtcgccgagg aaacagttcg cgtatccgcc gacctcttcg
     6961 ccgccgatgt ccacccgcca gccgaagagt cctgagtaga actccgcggc ctgggcgacg
     7021 tccgtgccga gatcgaccca gcagggcgtt cccgcgggcc aggcggtgtt ccgggtgacc
     7081 attgatcgac ctccgtcttg ttcctgtggg acccgcggtc gcgggtccgg gtgcacgcta
     7141 actccgccag gagggttgtg tgcgtcacga ttgaggcgtc gatcccagga aaaatgggcg
     7201 ggcgcgaggt gtgttccgga aggatcaagc gggcgaatcg gcggcaaacc ggacatagcg
     7261 gctggagatt tcatgcggct cggcgtcaag gggacagctc tgttcgcgct ctgcctgagc
     7321 gcactgctcg gatgcgggtc ctcgccgggc gccggggatc cgccatgcac cgcgatcggc
     7381 tcgcctgcgg ccatcagcct cgacatttcc ccagagaccg ccccagcgat ctccgcggcg
     7441 actcccccac cgaccgggca gctcaccgcc tgctggggcg gcgagtgccg caccgcccag
     7501 ctggacctgc gcgccgcgac cagcgcgggc gccacgacct gcgtcgacga gaactgctcc
     7561 gcccagatga ccccgaccgg cgggctcgcc gggttcgtcg aactgcccga cctgcccaag
     7621 gacacaccgg tggcggtgac cctcgccctc ggcggcgcgg agcaccgggt cgaggtcgtc
     7681 ccgcgggcga cgttccccaa cggccccgag tgcggcgaag gcgggccgca ggcacggctg
     7741 acgctgaacc agggcgggct gtccgcgggc tgagcccgac cgcgcccgcc gatcggccat
     7801 ccggatcaac cgtttagccc ttgcgcgccg atcatcgaac ctggatagtt tctggcgaac
     7861 tggggcttga ttctggggga ttcacccgac accggacatc ccgcctttcg gtatgcccat
     7921 aaacagcaca ctcggggggt cgaatgcgcc cgcgcgcgcg aaacacgaca acaaggatca
     7981 ccgcggcgac aatcacactg ggcttggtct gcgccgcggc ggcgcccgcc accgcggaca
     8041 gcgcggccga ccgtccgcgg accgcatcgg cccgcacggt cacgctcatc accggcgacc
     8101 gcgtcctggt ccccgcgaac ggcgccggac ccgcggtcca gcccgccgat ggccgcgtgg
     8161 acgtcgtctt ccacacccac accgtcgcgg gccacctgca cgtcatcccg gccgacgcgc
     8221 tgccgctggt ctcgtccggc acgctcgacc gccgcctgtt cgacgtcacc ggcctgctcg
     8281 aagcgggcta cgacgaccgc cgcgccgacc tgccgctcat ccagtccggc ccggcccccg
     8341 cgggcctgtt ctccgcgacc ggcgtgcggg cggtgcgcga cctcccgtcg gtcggcgccc
     8401 gcgccctgtc ggcggacaag gcggctctgg cgggctcgtg gcgctcgctg gtgggcgagg
     8461 gcacgctctg gctcgacggc aagcggcagg ccaccctcga ccgcagcacc gcgcagatcg
     8521 gcgcgcccga ggcgtggcgc gcaggcctcg acggcagcgg cgtcacggtc gcggtcctgg
     8581 acaccggggt cgaccagacc cacccggacc tggcgagccg cgaggtcggg gaacgcaact
     8641 tcaccgactc tgccgacacc gtggaccgcg ttggccacgg cacgcacgtc gcctcgacca
     8701 tcgcggggac cggcgggaag tacaagggcg tcgcgcacgg cgcgaagctg ctcgacggca
     8761 aggtcctcga cgacttcggg tccggccagg agtcgtggat cgtcgcgggc atggagtggg
     8821 cggccgagca gggcgccgac atcgtgaacc tgagcctggg cggcagcgac ggccccgagg
     8881 aagacccgct ggaggcggcg gtgaaccgcc tgtccgcgga gaaggggacc ctgttcgtca
     8941 tctcggcggg caacgcgggg ccgagggcgc ggacggtgtc gtcgccgggc agcgcggacg
     9001 ccgcgctcac cgtgggctcg gtcgagcgcg acgactcgct gtcgttcttc tccagccgcg
     9061 gcccgcggat cggcgacggc gcggtcaagc cggacatcac cggccccggg tccggcatcg
     9121 tggcggccaa ggcggcgcag ggccagatcg gcgacccggt cgagccgggg tacgtgagcc
     9181 tgtccggcac gtccatggcg gccccgcacg tggcgggcgc ggcggcgatc ctggcccagc
     9241 ggcaccccga gtggtccggc gcgcggctca aggccgcgct gaccgcgtcc gcgaagccga
     9301 cccagggcct gagcgcgttc gagcagggct ccggccgggt cgacgtgccc gcggcgctgg
     9361 cgcagaccct gacgaccgag ccgtcctcgg tgagcctggg cacccagctc tggccgcacg
     9421 acgacgacaa gccggtcagc aaggagttca cctaccgcaa cagcggcgac cagccggtga
     9481 ccctggacct gacgaccgag gtgctcgggc cggacggcaa gcccgcgccg cagggcatga
     9541 tcacgctctc ctccacccgg gtggccgtcc ccgcgggcgg cacggcgtcg gtccaggtca
     9601 tcggggacac ccggctcggc tccctcgacg gcatgtactc cggcgcggtc gtcgcgacca
     9661 ccggcacggc cgcggtccgc acgccgctgg cggtggagcg cgaggtcgag agctacgacc
     9721 tgcgggccac cttcctcggc cccgacggga agcccaccgc cgagttcagc acgctggtcg
     9781 tcggcctgga cagcgacttc ttcaccttcg caggcgaccc ggagggcgtg gtggacctgc
     9841 ggctgcccaa gggccgctac atcctgaaca acctcttcgc ccaagcggcg acgcgcgccg
     9901 tgcagcacct gccgtacccg ggtttcgaga tgacgaagaa gaccgatctc gtggtggacg
     9961 cccgcgtcgc caagcccatc aagatcaccc cgcccgaccc ggccgcggag cccgcgctga
    10021 gcgccagcgg gtacagcgtc tccacgccag agcgcggcgc gagcttcacc gtggccgtcc
    10081 gcgacccaag cacgctcagc atcgggcaga tcggccctga gctgcccgcg gacatgctca
    10141 cctggtcgct gaacgtgggg ctggagtcgc ccaccgcgta ctacgggctg gcctggttcc
    10201 aggaccgggc cgtgccgacc ggcttcaccc gcgcggtgcg gcagcaggac ctcgcgacag
    10261 tgcgcaccac ggtcggccaa gtcgtgcccg gaacgaccgc cgcccggttc ctcggcgcgg
    10321 tgcccgccgc gggcgacagc ggtggcttct ccatcggcag gaacgtgcgg gcgggcgtgc
    10381 tgaccgagca cctgctggcc gacaacacgc ggtggaacag cagcctgatg ctcttcggcg
    10441 acaccccgca ggactcgggg ctgggcggcc agttcatcgc cgagccgctg gtcgcccagg
    10501 cgggcaagac gtaccggcag cgggtcaacg tcggcgtctt cggccccgcg ctcccgcgcg
    10561 ccgagttccc gtggctgcgc cggttcgacg tgcccccgac cgggggcaac ccgcacgcgg
    10621 acatcctcag cgccgacatc ggcctgttcg gcgacggcgg cggcaacgcg ggcttcacgg
    10681 ccaccacggc ggccaagacg accctgtacc gcgacggcgt caagatcggt gagacggcct
    10741 tcccggcagg cggctcgttc gagatcccca agtcggcggg ccggtacacg ctcgccgccg
    10801 aggg
//
