LOCUS       NZ_FMZZ01000001        22585 bp    DNA     linear   CON 09-DEC-2024
DEFINITION  Actinokineospora iranica strain IBRC-M 10403, whole genome shotgun
            sequence.
ACCESSION   NZ_FMZZ01000001
VERSION     NZ_FMZZ01000001.1
KEYWORDS    WGS; RefSeq.
SOURCE      Actinokineospora iranica
  ORGANISM  Actinokineospora iranica
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Pseudonocardiales; Pseudonocardiaceae; Actinokineospora.
REFERENCE   1
  AUTHORS   Varghese,N. and Submissions,S.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-OCT-2016) DOE - JOINT GENOME INSTITUTE, LBNL, 2800
            Mitchell Drive, Walnut Creek, CA 94598, 94598, USA
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_900101685.1-RS_2024_12_09
            Annotation Date                   :: 12/09/2024 15:26:45
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.9
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,202
            CDSs (total)                      :: 6,139
            Genes (coding)                    :: 6,038
            CDSs (with protein)               :: 6,038
            Genes (RNA)                       :: 63
            rRNAs                             :: 3, 4, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 3 (5S)
            partial rRNAs                     :: 4, 4 (16S, 23S)
            tRNAs                             :: 49
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 103
            CDSs (without protein)            :: 101
            Pseudo Genes (ambiguous residues) :: 0 of 103
            Pseudo Genes (frameshifted)       :: 25 of 103
            Pseudo Genes (incomplete)         :: 89 of 103
            Pseudo Genes (internal stop)      :: 7 of 103
            Pseudo Genes (multiple problems)  :: 18 of 103
            CRISPR Arrays                     :: 3
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 18:38:36
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 517317
            Orig. end                         :: 539902
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            FMZZ01000001.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22585
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lassopeptide"
                     /region_number="4"
                     /rules="(PF13471 and Asn_synthase or micJ25 or mcjC)"
                     /tool="antismash"
     cand_cluster    1..22585
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /kind="single"
                     /product="lassopeptide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22585
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12585](+)"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12585
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
     misc_feature    180..193
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 14.64"
                     /tool="antismash"
     misc_feature    190..203
                     /note="TFBS match to PsrA, Oleic acid responsive regulator,
                     confidence: weak, score: 18.26"
                     /tool="antismash"
     misc_feature    complement(335..350)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 21.58"
                     /tool="antismash"
     misc_feature    681..695
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 18.92"
                     /tool="antismash"
     gene            complement(753..2534)
                     /locus_tag="BLS56_RS02415"
                     /old_locus_tag="SAMN05216174_101494"
     CDS             complement(753..2534)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="BLS56_RS02415"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="SAMN05216174_101494"
                     /product="type IV secretory system conjugative DNA transfer
                     family protein"
                     /protein_id="WP_175482624.1"
                     /transl_table=11
                     /translation="MRSAVSGGRPEDCRASPGDGPAAGRINGGPTTGAAVRGRVVTRPD
                     PYRPARRAARPAPGDRPDRAGDAAAGRPGRLRLPPADHPARMTAKPLGVANDGPPDVIG
                     LAVPDARHHLHVQGVTGTGKSTWLANLALSEADAGRGVVLLDCQGDLARNVLDRLPARC
                     GDRLVILDPAETDAPPAWNVLAPVGTAGADDLAGREWAAENVVGVFRRLYAAWWGPRMD
                     DVMRAACLTLARRPGSTLADVPTLLTHAGFRRGVLDKHGEPEGIDGFWSGFDLLSDGQR
                     AQVCGPILSRLRGLLARRFARDLLGSARSTVNLTDVLNGGILIARLAKGEIGEDTARIV
                     GSLLLSGLWAHTVRRSALPPDERPDATIIVDECHNFLHLPIGVDDTLAEARGYRVSLVL
                     AHQHLAQLPSDVREAVDANARNKVIFTVSPDDAAKLARHVTPYFEATDLARRPGFEVVA
                     RVVHHGRDVPPFTLATEPLPPAISGRADRLRAAARTRTGLSRTERDATAASRKVASKPG
                     VADLRADLQHPAGARPPGRGGGGSGRGSSPGIPGSSLPGISGGTLRPAGGTATPGRGLS
                     AGHDDMEEPWGEPDWLP"
     misc_feature    complement(849..851)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    3309..3323
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.92"
                     /tool="antismash"
     misc_feature    complement(3776..3792)
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 16.84"
                     /tool="antismash"
     misc_feature    complement(3780..3793)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 14.35"
                     /tool="antismash"
     gene            complement(3981..4811)
                     /locus_tag="BLS56_RS02420"
                     /old_locus_tag="SAMN05216174_101496"
     CDS             complement(3981..4811)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF022388.5"
                     /locus_tag="BLS56_RS02420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216174_101496"
                     /product="DUF2637 domain-containing protein"
                     /protein_id="WP_091447730.1"
                     /transl_table=11
                     /translation="MSTPTFEPWRSAVGAGWRRWVQRASAAVVAGVAAYASYDHQELFA
                     RTHGADGVAAAVWPLSVDGLVVLACVALLDPAVGRARPWLRLVVRAAFVAGVGMSMLAN
                     IAAGTTAGAGGRWDWAGVAVSGWPPVALLLAVEILMHSLTRDVPAETNATAETTPGETE
                     TAPNGPVALVSVDGPPVAAGRARGDSARVMWAHYQAARAAGRTPTGAELDRIAGTRDYG
                     RAVLARWRRTGRIPADAPAVTATVPVDDETTTSDVSSLVDVRSAEGGGDSQAAA"
     gene            complement(4808..5437)
                     /locus_tag="BLS56_RS02425"
                     /old_locus_tag="SAMN05216174_101497"
     CDS             complement(4808..5437)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="BLS56_RS02425"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="SAMN05216174_101497"
                     /product="hypothetical protein"
                     /protein_id="WP_091447732.1"
                     /transl_table=11
                     /translation="MSNYAGSDVRRDAAMPRGFAPEDGMPDEIRRTERLRGREVGYRLA
                     ESLIIHGAPAEVAALLIAVPHDEPDAERKWAVRVEDAELCGDRRRCSMPVRGCRHHGDT
                     VAWRYGEWVCRVPKCRGRVARRLQRRHCDLLTVAVIDYPSGHQRRVCAGHLASEQAVWA
                     EAPAETPTIRVTPVPTGPAAEADTASTAGAAEVPGPSRLTVVDGGR"
     gene            complement(5518..6192)
                     /locus_tag="BLS56_RS02430"
                     /old_locus_tag="SAMN05216174_101498"
     CDS             complement(5518..6192)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="BLS56_RS02430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="SAMN05216174_101498"
                     /product="hypothetical protein"
                     /protein_id="WP_139190465.1"
                     /transl_table=11
                     /translation="MTAVDVWDGTDGADDGGEIEDFTRIPYPDAWNRDPEDGTDGTSGL
                     EVDGDGFARELLDAANAWYRVVELLIDQGFAPEDCEAEVVRRCAKVSRGQRALMRGIAQ
                     EEAEYGQLAADESACDFPWGRLCPEHGKTLREGRRGCYCAYEGCERRWPVGYSRGHCDQ
                     PAAVLVVSAFKNGEWRLCAEHRRLHPAGRTPRTFQASALMVAGPPDAASPAVESDSDRR
                     DG"
     misc_feature    complement(6725..6740)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: strong, score: 19.26"
                     /tool="antismash"
     misc_feature    complement(6932..6947)
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 21.34"
                     /tool="antismash"
     gene            6981..8333
                     /locus_tag="BLS56_RS02435"
                     /old_locus_tag="SAMN05216174_101499"
     CDS             6981..8333
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018685014.1"
                     /locus_tag="BLS56_RS02435"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216174_101499"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_091447737.1"
                     /transl_table=11
                     /translation="MNTAGDDPRMIIDPSVWQEPETRAALRVRDIGTVYRQLKRHGVSQ
                     RRIAALTGQSQPEVSEIMRGRQVMAYEVLSRIADGLGVPRGLMGLAYDSPRVASCAGPT
                     EGESDVERRGFIGLVAKAAVVGLSGAELDSIRVLHQATPMPGRIGHADVSNLETTVQFF
                     RAQDDQFGGGAVKSAVVGHLEWATGMLESPAADDVRNRLRIALADMHSLAGWVSFDLGA
                     HEQANRHFANALVLAKESKEHALASKVLFQMGRVYLHQKEPENALKIFQLGQMSAQDAN
                     SHRAVALNLAVSAWAHAEMGNAEQTKSLLAHASGELSRDNGQDIPTWLNFMGVAEIEGI
                     SGMAYTALSGHDRSFADLGIQHASRSFEMRDESDARSRASDLIAIAANNLRAGNVTEGI
                     RAASDVLPRLDSVRSTRLMDRLTWVRQATNLHPSSGEARELAERITELRSA"
     gene            8581..9240
                     /locus_tag="BLS56_RS02440"
                     /old_locus_tag="SAMN05216174_101500"
     CDS             8581..9240
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF020811.5"
                     /locus_tag="BLS56_RS02440"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216174_101500"
                     /product="bifunctional DNA primase/polymerase"
                     /protein_id="WP_091447739.1"
                     /transl_table=11
                     /translation="MTERKGLTMSATAVENHGLNEQTTERLSEQEKAAVLYAAHGWPVL
                     PGSTWNGRRYVVPATLKVTNGLRPWVARNLASADVATVTRWWSADTRLAPSVLLLTGEA
                     FNLVSVAFELAQDVLATTAFLDNAGPVMYRPDEGRAYFLLQPGPIQFDDLDIAPGEVAN
                     IAPGKWVAAPPTRTGNGVNVRWWSTPESVNWRLPDVAVLYEALAVACRDRINSSAR"
     misc_feature    9479..9493
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 17.12"
                     /tool="antismash"
     gene            9805..9921
                     /locus_tag="BLS56_RS30335"
                     /old_locus_tag="SAMN05216174_101501"
     CDS             9805..9921
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF033525.2"
                     /locus_tag="BLS56_RS30335"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216174_101501"
                     /product="albusnodin family lasso peptide"
                     /protein_id="WP_139190466.1"
                     /transl_table=11
                     /translation="MESAEMVGSGQLVDLGDMAALTLGSGRSTQEAKRHIYN"
     gene            10001..11836
                     /locus_tag="BLS56_RS02445"
                     /old_locus_tag="SAMN05216174_101502"
     CDS             10001..11836
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Asn_synthase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1177: asparagine synthase (glutamine-hydrolyzing)"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020636185.1"
                     /locus_tag="BLS56_RS02445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216174_101502"
                     /product="albusnodin/ikarugamycin family macrolactam
                     cyclase"
                     /protein_id="WP_091447741.1"
                     /sec_met_domain="Asn_synthase (E-value: 9.2e-25, bitscore:
                     84.0, seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLWFGGFSGKTGPPRVPVGVRNLWPTVPGGGWLHGGWPTHEVRTK
                     RTGRRSLAVLGPCGMTSDELARLAVHGVPDDVAWRWPGSYTVVAADDDGRTTIWTDVGG
                     ACPIYTLTVDGGVYWSSSSRALAGLTGNHIDPDWLAAWLAARGVSPLVDGRSAFTNVAA
                     LPAGHRVSVSANGTVDAQRVWWPRPRHADHVARLRHELTAAVALRVDVAESPTADLSGG
                     YDSTSLVLLAAERLHPGRAVTGVTLHPDGITTGGDASYARLAGRMPGIDHQWLPLGAEH
                     RPFGELDRVPVTDEPAPSALGYASFRAQLEWLRERRASDCHMTGDGGDALICTPALFLA
                     DLVRTRRYGRALADVMRWARLARRSVFPLLGAAVRTARTTRTDALDTVLTSLAEFGSQA
                     AIGDVAWFPAASPPSWATDGLRERVAALASSAINAGRSTDGDDWPDFTTQHMASVMATT
                     GRTARADVELAAWSGVPLHNPFLDSRLIDVCLSVPLADRRGPAEYKPLMRAAFDDLFPE
                     PLKRRVSKGDMTPDYYQGLRANLAAVTDMADGRLAELRLASPAVLRRIIPLAAAGVPAA
                     YGALETAISAEVWLRAIDTAPAVPWEAAKSIREAA"
     gene            12001..12585
                     /locus_tag="BLS56_RS02450"
                     /old_locus_tag="SAMN05216174_101503"
     CDS             12001..12585
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: PF13471"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF033537.1"
                     /locus_tag="BLS56_RS02450"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216174_101503"
                     /product="lasso peptide biosynthesis B2 protein"
                     /protein_id="WP_228771379.1"
                     /sec_met_domain="PF13471 (E-value: 1.1e-22, bitscore: 76.3,
                     seeds: 84, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDRASARALLGQLHGAGLLTAADRPRPWPAPVAGRPLTPSWGTQT
                     VNAGRTPIPSVPYRALPLAALALAVVLAVEHIGPARFRMARITHLLSRATRRTVTCAST
                     DQARRAVHAVRRVGLLTPGRVACLEESAAVALMLAVSRQRVTWCHGVAADPICLHAWVE
                     TDDQPVAEPESTHRYTALRTIPAQLTGDGQN"
     gene            12572..13177
                     /locus_tag="BLS56_RS02455"
                     /old_locus_tag="SAMN05216174_101504"
     CDS             12572..13177
                     /EC_number="2.3.-.-"
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0016746 - acyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1111: GCN5-related N-acetyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009086157.1"
                     /locus_tag="BLS56_RS02455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216174_101504"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_091447745.1"
                     /transl_table=11
                     /translation="MVKISDATPDTSADREPTLWLRGEKAALGPFLRDLVPLYWRWETD
                     PRSLLGFGQQYAETVQTRAGVFDAQSRDGSPYFTIYDTTGSEPIPVGMSQLIVDNRTRT
                     GEFIILIGEEGRGKGIGTEATRLTLDYGFHVTALRNVYLSVVASNFAGIRAYEKAGFKV
                     IGRRRNSGHWFGEIVDHVLMDAIPADFPGPSVVKNIVG"
     gene            13202..13807
                     /locus_tag="BLS56_RS02460"
                     /old_locus_tag="SAMN05216174_101505"
     CDS             13202..13807
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF025406.5"
                     /locus_tag="BLS56_RS02460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216174_101505"
                     /product="NucA/NucB deoxyribonuclease domain-containing
                     protein"
                     /protein_id="WP_091447748.1"
                     /transl_table=11
                     /translation="MSTRTKGGILLPILLVVGGYFVVTETDLGSKIGDIFASPGGEPQG
                     VAVPPEFHGRVKSCTAVQLAADKRCGDDKVLPIDAAKMPYIARNITLAWESRPETAALT
                     KASYKERQNYRASGCGRFARTIRSDDPKKAGSCDEFPFKSTEEGGTGSRIEEVPTGEQN
                     IQGGTISSFYQKHKMVDGDKYLVVIINPASIATGPYEG"
     misc_feature    13232..13234
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            13810..14382
                     /locus_tag="BLS56_RS02465"
                     /old_locus_tag="SAMN05216174_101506"
     CDS             13810..14382
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="BLS56_RS02465"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="SAMN05216174_101506"
                     /product="DUF6461 domain-containing protein"
                     /protein_id="WP_091447750.1"
                     /transl_table=11
                     /translation="MLDTATYQWINDERYSAITLAIVAGTAEDDVIRAYGGTPETSEIA
                     TFDESFNSFDDGQPFHVQTFTTGQFVVAVENNGFHGSDSRIARKVTGESGRFISVKWSS
                     TGGDYILYVVGHKIEAQFDALSVSLGGDGDGIVPEWVNRVDWSQDETRAPYLALLGDVM
                     GVHVSQEWFTTPHRTTVIPELYSMADL"
     gene            complement(14471..15418)
                     /locus_tag="BLS56_RS02470"
                     /old_locus_tag="SAMN05216174_101507"
     CDS             complement(14471..15418)
                     /GO_function="GO:0000155 - phosphorelay sensor kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1048: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF019350.5"
                     /locus_tag="BLS56_RS02470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216174_101507"
                     /product="sensor histidine kinase"
                     /protein_id="WP_091447755.1"
                     /transl_table=11
                     /translation="MPDVRGSLTRQSLLVAGVCLVADSALYLALRASVDWGWQGWALHG
                     AIVLADLALVASVRHSGAVAIGQATLGLLEALLWAHGAGTRVAGSFGFAVATYQAGAWL
                     RGRWAVAVFATLILGELGRHLVAGDWVVHRWPALLGLALGLVVLPWLVGRATTTRQTYL
                     AGLAAEAELARRDERAAVRRAVAEERGAVARDLHDVISHYVSAIAMHAGVARMSLNGTG
                     PTQAGQSLSEVESASRAAMVELRRMLDLLHGQDIDDSQRQPGLHGIGDLVDRVRAAGVA
                     ARLTLRGTPPRLPESLDVALYRIAQANPHLVTVS"
     misc_feature    complement(14486..14488)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(<16037..16441)
                     /locus_tag="BLS56_RS02475"
                     /pseudo=""
     CDS             complement(<16037..16441)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007023412.1"
                     /locus_tag="BLS56_RS02475"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="NAD(P)-binding protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MTTTEHVDVLIVGAGLSGIGAARHIQEAFPRRSYTILEARAAIGG
                     TWDLFRYPGIRSDSDMNTLGYRFRPWTNPKSIADGPSILRYVRDTAAEEGIDRHIRCGH
                     RVIRAEWSTQDARWTVDAVHDGVPVTFTCHF"
     gene            complement(16441..17121)
                     /locus_tag="BLS56_RS02480"
                     /old_locus_tag="SAMN05216174_101510"
     CDS             complement(16441..17121)
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_KR (5-126). E-value: 2.3e-12. Score:
                     39.2. Matches aSDomain:
                     nrpspksdomains_BLS56_RS02480_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF024950.5"
                     /locus_tag="BLS56_RS02480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216174_101510"
                     /product="SDR family oxidoreductase"
                     /protein_id="WP_228771287.1"
                     /transl_table=11
                     /translation="MLTRVLDVRDADDQLRFAAEVRDWLPAPLAAVFNNAGVAVASTVL
                     NAVPEDDQWLWDINFHGVVNGTRAFLPILAAQGSGAIVNTSSVFGLVGMPYQSAYCAAK
                     FAVRGFTDALRQELRGTGVRAITVHPGGITTNIVRNARMREDPEGLGRTREQMAAQFEA
                     VTLTSPDKAARIIVAGVERGKARILVGPDAYLFDALSRISPTHYYAVLGLLRNRLRDRA
                     GKVN"
     aSDomain        complement(16744..17106)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_BLS56_RS02480_PKS_KR.1"
                     /evalue="2.30E-12"
                     /label="BLS56_RS02480_PKS_KR.1"
                     /locus_tag="BLS56_RS02480"
                     /protein_end="126"
                     /protein_start="5"
                     /score="39.2"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="LDVRDADDQLRFAAEVRDWLPAPLAAVFNNAGVAVASTVLNAVPE
                     DDQWLWDINFHGVVNGTRAFLPILAAQGSGAIVNTSSVFGLVGMPYQSAYCAAKFAVRG
                     FTDALRQELRGTGVRAI"
     CDS_motif       complement(16813..16875)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_BLS56_RS02480_0001"
                     /evalue="8.30E-05"
                     /label="PKSI-KR_m4"
                     /locus_tag="BLS56_RS02480"
                     /protein_end="103"
                     /protein_start="82"
                     /score="15.1"
                     /tool="antismash"
                     /translation="VNTSSVFGLVGMPYQSAYCAA"
     gene            complement(17151..17291)
                     /locus_tag="BLS56_RS32010"
                     /old_locus_tag="SAMN05216174_101511"
     CDS             complement(17151..17291)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="BLS56_RS32010"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="SAMN05216174_101511"
                     /product="SDR family NAD(P)-dependent oxidoreductase"
                     /protein_id="WP_228771288.1"
                     /transl_table=11
                     /translation="MPQPSREIGGRPVVVTGAASGIGRGLAQRLSKSGSPVAIADIDRS
                     A"
     gene            complement(17272..17826)
                     /locus_tag="BLS56_RS02485"
                     /old_locus_tag="SAMN05216174_101512"
     CDS             complement(17272..17826)
                     /NRPS_PKS="Domain: Abhydrolase_1 (7-161). E-value: 4.1e-15.
                     Score: 48.0. Matches aSDomain:
                     nrpspksdomains_BLS56_RS02485_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1036: alpha/beta hydrolase fold protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012770.5"
                     /locus_tag="BLS56_RS02485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216174_101512"
                     /product="alpha/beta fold hydrolase"
                     /protein_id="WP_228771289.1"
                     /sec_met_domain="Abhydrolase_6 (E-value: 1.3e-07, bitscore:
                     28.6, seeds: 455, tool: rule-based-clusters)"
                     /sec_met_domain="PF00561 (E-value: 9.3e-11, bitscore: 37.9,
                     seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAGDTVGLIDALGFADVHLVGVSMGGMIAQTVAALTPARVRTLTS
                     IMSTTGARRVGRPAWSALRRMGGRPPATRQAHADRLVGMYRHIGSHGFPAVRACAELAW
                     ERDPSGQGVARQLAAIVKSGDRTARLAAIAAPTLVIHGDRDRMVNPTGGGATARANPGS
                     SSTATSAEPTQSRSDDAPTVP"
     aSDomain        complement(17344..17805)
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_BLS56_RS02485_Abhydrolase_1.1"
                     /evalue="4.10E-15"
                     /label="BLS56_RS02485_Abhydrolase_1.1"
                     /locus_tag="BLS56_RS02485"
                     /protein_end="161"
                     /protein_start="7"
                     /score="48.0"
                     /tool="antismash"
                     /translation="LIDALGFADVHLVGVSMGGMIAQTVAALTPARVRTLTSIMSTTGA
                     RRVGRPAWSALRRMGGRPPATRQAHADRLVGMYRHIGSHGFPAVRACAELAWERDPSGQ
                     GVARQLAAIVKSGDRTARLAAIAAPTLVIHGDRDRMVNPTGGGATARANP"
     CDS_motif       complement(17725..17778)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_BLS56_RS02485_0001"
                     /evalue="1.70E-05"
                     /label="NRPS-te1"
                     /locus_tag="BLS56_RS02485"
                     /protein_end="34"
                     /protein_start="16"
                     /score="17.4"
                     /tool="antismash"
                     /translation="VHLVGVSMGGMIAQTVAA"
     gene            complement(17832..18104)
                     /locus_tag="BLS56_RS32015"
                     /old_locus_tag="SAMN05216174_101513"
     CDS             complement(17832..18104)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="BLS56_RS32015"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="SAMN05216174_101513"
                     /product="alpha/beta fold hydrolase"
                     /protein_id="WP_228771290.1"
                     /sec_met_domain="PF00561 (E-value: 1e-05, bitscore: 21.4,
                     seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTEQITDVGPGIALCWERIGDPGADPLLLVAGLGQRLHAWPTGFR
                     AGLADRGYQVIRFDNRDVGRSTHAAFPPPWPAATWPGAGRRGNTT"
     gene            complement(18101..19507)
                     /locus_tag="BLS56_RS02490"
                     /old_locus_tag="SAMN05216174_101514"
     CDS             complement(18101..19507)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009154682.1"
                     /locus_tag="BLS56_RS02490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216174_101514"
                     /product="cytochrome P450"
                     /protein_id="WP_324187489.1"
                     /sec_met_domain="p450 (E-value: 3.7e-57, bitscore: 190.1,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSAYHPAVHRRTKGEKGNCSMATTTLPPGPSVPNLIQGMAVMAGG
                     RRTMRRLRDRYGDAFTLWMPILGPTVVVSAPAEVRQLFQTPADVADYHDVMNLGRVLGP
                     GSLFALSGAEHRAQRKLLVPPFHGRRLRAYEAIVEEETLRELASWPENVAFASQPSMMR
                     ITLNIILRAVFGADGAEFAHLRELLPRAVTLGSRLALLPRPSVNLGRWSPWARLDALRC
                     EYGEIIDRMITRAEADQRLDERDDVLALLVRSRYEDGSAMTRGDIADELITMLAAGHET
                     TATTLAWVVERLRRHPTVLRDLVDEVDAGGSTLREATLLEVLRTRPVITQTLRQVKADS
                     MTLGRWTVPKGHSVFASIALIHEDDAVFPDAHRFDPTRFVGTKPDLYQWVPFGGGHRRC
                     IGAAFATMEMNIVLRTILREVTLVPTADRDERWQFRGIAYAPGRGGRAVVRRRTGRQAP
                     QSVAATGGRA"
     gene            19557..20177
                     /locus_tag="BLS56_RS02495"
                     /old_locus_tag="SAMN05216174_101515"
     CDS             19557..20177
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007023414.1"
                     /locus_tag="BLS56_RS02495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216174_101515"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_228771292.1"
                     /transl_table=11
                     /translation="MTATRRGQAEPASSGEASAFRRRLLDGLAESIAAVGYRNTTVADI
                     VRRARTSRRTFYEHFASREACLLALVADSTAQTIGQIVAAVDPTRPWEHQVRQAIEAWI
                     TRVESEPELIVSWIRDVPTLGDVARQLQHDTMEAFITMVRTLADTDEWRAAHGDPPSRE
                     MAIILLGGLRELIASTVENGGRVRDITETAVRAAIVLGRASAL"
     gene            complement(20271..20522)
                     /locus_tag="BLS56_RS02500"
                     /old_locus_tag="SAMN05216174_101516"
     CDS             complement(20271..20522)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="BLS56_RS02500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="SAMN05216174_101516"
                     /product="hypothetical protein"
                     /protein_id="WP_228771293.1"
                     /transl_table=11
                     /translation="MACEQGRKPLSFHRRGKGRGGGRPPVFDRDACEQRHAVECGIDQL
                     TQHRAVATRYDKLAVRYTATIHNAAIHIAAITIWLRQL"
     gene            20817..21401
                     /locus_tag="BLS56_RS02505"
                     /old_locus_tag="SAMN05216174_101517"
     CDS             20817..21401
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009947213.1"
                     /locus_tag="BLS56_RS02505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216174_101517"
                     /product="dihydrofolate reductase family protein"
                     /protein_id="WP_091447764.1"
                     /transl_table=11
                     /translation="MTATYTFDVFSSLDGYASYNSDGDWGGYWGKQGPEFLDHRLALYR
                     EKQRMVLGANTFRQFVQMLGPRTGELKELDPVNTQMRNMPTTVVSTTLEGPLDWPDATL
                     VSGDALDVVARLKEESDVPLRSHGSLSMNRALMAAGLVDRVQLTIFPVITGLTGVEPVF
                     KDAADFDLELIESRTLDGHIQELIYRPTLHA"
ORIGIN
        1 ggcgacgctg agcccggcca ggtcgcggga ccgggccgac gccatgcggt gaaagttgtt
       61 ctgccgggtc acgccggcga aaatgaacag aatcgggtga ctgattccgg ccatagcgag
      121 gtttcggtat ccctcgaact tccctgccag cctttccagc gtttcggttc cgttgtcgta
      181 ttcgacaaag aaacgcacgt tacgcccgga ttcctgccat tctccgtagc cgtccgggcg
      241 gaccagttcc cccacggatt tagccacctt gcgttcggac caccattcca ccaacgcgca
      301 tccgtcgcgc ctgttcgcct ggttgtgcag tcgggtgaag aagtcgttga tgcccagcag
      361 gtgatcgagt ttgggtgatt ctgcgagcgc aagaatggtt tcggtgatgc gggacggtcg
      421 cggaatggag cgaccggcgc gggcagcgtt catcatgacg ccgagcacgc cgagcgtgta
      481 gcgccaggac tgggagccgg acggcaggca gcggcggaac cgggccagca cgccgcgctt
      541 ggtgagcgtg gcgaggcggt gctgtgcggt gatgtggctg gtgaaggcca cgcgggtgat
      601 ctgttcggtg gtcaggacgc ggtgtgcggc gagcagggcg aggactcgcc ggtctcggtc
      661 ggtgaggtgg cggcccgcgt cgatcgcatc ggccacgctg cccgtcgtga tggtgatggt
      721 ggaccgtgtt gccgtgtggt tgtttggtgt ggctacggta gccagtcggg ttcgccccat
      781 ggttcctcca tgtcgtcgtg accagcggaa aggccccggc caggggtggc agttcccccg
      841 gcaggtctta aggtgccacc ggagatgccg ggcaagctgc taccggggat gccgggggaa
      901 ctgccccggc ccgaaccgcc gccaccgcga ccaggaggac gggcaccggc cgggtgttgg
      961 agatcggcgc gcagatcggc tacgccgggt ttgctggcca ccttgcggga tgcggccgtg
     1021 gcgtcgcgtt cggtgcggga caggccggtc cgggtgcggg ccgccgcgcg gagccgatcg
     1081 gcccggccac tgatggcggg cggtaggggt tcggtggcca gagtgaacgg cggcacgtcg
     1141 cggccgtggt ggacgacccg tgcgacgacc tcgaaacctg gtcgccgcgc caggtcggtt
     1201 gcctcgaaat agggggtgac gtgccgggcg agtttggccg cgtcgtcggg cgacaccgtg
     1261 aaaattacct tgttccgggc gttggcgtcc accgcttccc gcacgtcact gggtagctgt
     1321 gccaaatgct ggtgagccag caccaatgac acgcgatagc cgcgcgcttc ggccaatgtg
     1381 tcgtccacgc cgatgggcag gtgcaggaaa ttgtggcatt cgtccacaat gatggtcgcg
     1441 tccggccgtt catcgggcgg gagtgcggac cggcggacgg tgtgcgccca cagaccggac
     1501 aacaggagcg acccgacgat ccgggcggtg tcttccccga tttctccttt cgccagtcgg
     1561 gctatgagaa tcccgccgtt caacacatcg gtgagattca cggtcgagcg agccgacccc
     1621 aacaggtcgc gggcgaaccg gcgggcgagc agcccgcgca gccgggacag gatcggcccg
     1681 cacacctggg cgcgctgccc atcagagagc aggtcgaacc cggaccagaa cccgtcgatg
     1741 ccctccggtt cgccgtgctt gtccagcaca ccgcgccgga acccggcatg ggtgagcagc
     1801 gtcggcacgt cggccagggt ggagcccggc cgccgcgcca gcgtcaaaca ggccgcgcgc
     1861 atcacgtcgt ccatgcgcgg tccccaccat gccgcgtaca gccgccggaa cacgccgacg
     1921 acgttctcag cggcccattc ccgccccgcc aggtcatccg cccccgccgt gcccacgggg
     1981 gcgaggacgt tccacgcggg cggtgcgtcg gtctcggcgg gatcgaggat gaccagtcgg
     2041 tcaccgcagc gggccgggag ccggtccagc acgttccgcg ccaggtcgcc ctggcagtcc
     2101 agcagcacca cgccgcgccc ggcgtcggcc tcggacagcg ccaggttggc cagccacgtg
     2161 gatttcccgg tgccggtcac gccctggacg tggagatggt gccgggcgtc ggggacggcc
     2221 agcccgatta cgtccggcgg gccgtcgttg gccaccccca acggtttcgc cgtcatccgg
     2281 gcggggtggt cggccggggg cagccgcaac ctgcccggcc gtccggccgc cgcgtcaccc
     2341 gcccggtcgg gacggtcacc gggtgccggg cgggcagctc gccgcgcggg ccggtacggg
     2401 tcaggccgcg tcacgacgcg ccccctgacc gccgcgcccg tcgtcgggcc gccgttgatc
     2461 cgcccggccg ccgggccgtc gccgggtgac gcgcggcagt cctcgggacg gccgccggac
     2521 acggccgacc gcatccgcca tgccgtactg ggtcggttcg gcgggaaggt gccacagccc
     2581 ggccagttcg gtgatggtga ccgcgaaccg gtaccgccgc cgggccggtc gccgctgatc
     2641 gaccagcgcc agcacccgcc gggcaccacc gacaccgcca ccgacccggt gcagccggaa
     2701 cgtcgccagc ggcgcggcca ggtcgaaccc gcccgccagc ccggccacca cccggcgctg
     2761 cccctgccga gtacgccggg agccccgcgc ggcggtgtgg tggacgacgc gcacgctcac
     2821 ccgcaggtgc gggccgtgcg ccttcttggc ggtgatcgcg cggcgccccg cctcgatcac
     2881 cggatcaggg tcgggtgcgg gccggtcggt ccgcaccgtc ggggcgccgc tgggacggga
     2941 ggacgtgaac aggtccagca ctccgagcac gccgcgcccg agcaaccgga acccgcctgc
     3001 gatggcccgc agccaccacg gccggtcagc cgcaccagga cgaccggtcg cgaactccgg
     3061 cgtgacgatc agttgcacgc accgctgttc ccccggcccg cagtcggaca acgcggagaa
     3121 caggccgcgc aacacgtcat cggtgccgac ctccaccggc cgggacgtcc gcgtagccgg
     3181 ttcggccagc ggcacccact gcccacccgc cgggtagacc tcggccgcgc tgacccggcc
     3241 cggtccggcc gtgtcagtcc agcggggagg gtcggtgacc tgtgcccgcg cgccgggcca
     3301 gacgtggccg accagttcgg ccacccgtcg taccggcaac tcaggcggca cccacacccc
     3361 ggcgcgcacc ccgtccgcgt ccgcgacgaa ctccaccgcg aggtgacgcg ggtcgatgcc
     3421 gcgccgggcg gtgcggtgca gcatcccggc cagtgaccgc caccaggccg gggcaccatc
     3481 gcgcggcagc gacgcgggcg gagtgatctc cacccaccgg gcggcatcgg ccgcgttgcg
     3541 tcgggccagg cgcaccgcgc gggccagcag cgccccggcg gccagggcga gcgcggcggc
     3601 caccgtcagc agcggccacc agacttgcag ccaccgccac agcgtgaacg acaccgccga
     3661 caggaacccg aacggcccgc tcgggtcgca caggtaggcg gccacgccgt gaacgtccga
     3721 acaggacgag cccggcgcac cgggagcgcc ccgcggagcc accgcggcca tgctaacgtt
     3781 gttgtgatac aatgggaaat ccttcagtgt gacggcgatc cgacagggat cagcgcggcg
     3841 cgaatcacga gacaggccct tccagcgggc acgcgaagtc cacgagagac gatcagctcg
     3901 ggacgtcccg gaaggtctcg ggttgtcccg ctcttgtctc gcgggacggg tgtcaggcaa
     3961 gcgtgacaat cacgccggga tcaggcggcg gcttgggaat cacccccacc ctccgcactg
     4021 cgaacgtcca caagagacga aacatctgag gtggtcgtct cgtcgtcaac cgggacagtc
     4081 gccgtgacgg ccggggcatc ggcggggatg cggccggttc gacgccaccg cgcgagcacg
     4141 gcgcggccgt agtcacgggt gcccgcgatc cggtccagtt ccgcgccggt cggggtgcgg
     4201 ccggccgcgc gcgcggcctg gtagtgcgcc cacatgacgc gcgccgagtc gccccgcgca
     4261 cgcccggccg cgaccggcgg cccgtcgacc gagacgagag caacgggacc attcggcgcg
     4321 gtctcggtct caccgggtgt cgtctcggcc gtggcgttcg tctcggccgg gacgtctcgg
     4381 gtcagcgagt gcatgaggat ttccacggcc agcagcagcg cgaccggcgg ccacccggac
     4441 acggcgaccc cggcccagtc ccaccggcca cccgccccgg ccgtggtgcc cgccgcgatg
     4501 ttggccagca tcgacatacc gaccccggcg acgaacgcgg cccgcacgac caaccgcaac
     4561 cacggccgcg cccggcccac cgccgggtcc agcaacgcca cgcacgccag caccaccagc
     4621 ccgtccaccg acaacggcca cacggcagcc gcgacaccat ccgcgccgtg cgtgcgggcg
     4681 aacagctcct gatggtcgta ggaggcgtac gcggccaccc cggcgaccac ggccgccgac
     4741 gcgcgctgaa cccatcgacg ccacccggca ccgaccgctg accgccacgg ctcgaacgtc
     4801 ggcgtgctca ccggccgccg tccaccacgg tcagccggga cggccccggc acctcggcgg
     4861 ccccggccgt gctggccgta tccgcctcgg cggccgggcc ggtcggcact ggcgtcacgc
     4921 ggatggtggg cgtttccgcc ggggcctcag cccacaccgc ctgttcggat gccaggtgac
     4981 cggcacacac ccgccgctga tggccggacg ggtagtcgat caccgccacg gtcaacaggt
     5041 cgcagtgccg acgctgtagc cgccgggcca cccggccccg gcacttcggc acccggcaca
     5101 cccattcccc gtaccgccac gccaccgtgt caccgtggtg acggcacccg cgaaccggca
     5161 tcgagcaccg ccgccggtcg ccgcacagtt cggcatcctc cacacgaacg gcccacttcc
     5221 gctccgcgtc gggttcgtcg tgcgggaccg cgatcagcag cgcggccacc tcagccgggg
     5281 caccgtggat gatcagcgac tcggccagcc ggtagccgac ttcccggcca cgcaaccgtt
     5341 ccgtacgccg gatctcgtcc ggcataccgt cctccggggc gaacccgcgc ggcatcgccg
     5401 cgtcccgccg aacatcactg cccgcgtagt tgctcatggt cgaaactcct tgccgtggtt
     5461 gggtcggtgc ccggccccgg acacaccggg ccggggccgg gcaccggtca gggctgatca
     5521 gccgtcgcgc cggtcgctgt ccgactcgac cgccggggac gccgcgtccg gcggcccggc
     5581 caccatgagc gcggaagcct ggaacgtgcg cggggtccgg ccggcggggt gcaaacgccg
     5641 atgctcggca cacaaccgcc attcaccgtt cttgaacgcg ctcaccacaa gcacggccgc
     5701 cggttggtca caatgaccgc gcgaataccc gaccggccac cgccgctcgc aaccctcata
     5761 cgcgcaatag cagccccggc gaccttcccg cagggtctta ccgtgttccg ggcacaaccg
     5821 accccacgga aaatcacacg ccgactcgtc ggccgccaac tgcccgtact cggcttcctc
     5881 ttgcgctatc ccacgcatca gcgcgcgctg accgcgtgac accttcgcgc accgccgcac
     5941 cacctcggcc tcgcagtcct ccggcgcgaa accctgatcg atcagcagct ccaccacccg
     6001 ataccaggcg ttcgccgcgt ccagcagctc ccgcgcgaac ccgtcgccgt ccacctccaa
     6061 cccggacgtg ccgtccgtgc cgtcctcggg gtcgcggttc cacgcatccg ggtagggaat
     6121 ccgcgtgaaa tcctcgatct ccccgccatc atcggcacca tcggtgccgt cccacacgtc
     6181 aacagccgtc atcaggacac ctttcatcct ggcgagacgg gaccgcctca ccatgaccac
     6241 gccatcggaa accaaacatc atcgaaaccc gacctgaccg gcaaaaatct ggtagtggtt
     6301 tcaccggacg acaggtcacc tgtcggcgca catcacccgg tgcgctattc ggttggagaa
     6361 cacaagggga atccggccgg acaacgccga cctgaaaggg atcaacagcc gcccacggca
     6421 cacgccaaga ggcaacccag cgctgcccag cccactgccg gagccacacg cccaacctcg
     6481 gtctgcgatg cgccctactc gcacgcatcg cgcgttgtgc cctgtcgtac cgcgcaccgc
     6541 cgggacacag gcactcgtgg ccctttcggg aaccttcacg agccggtaca caaccagcgg
     6601 agcccacatg aacaaccacg ccgcgccccg gaagacctcc cttccagcag tggagcacga
     6661 cccagcgacc catctaggac catccaaggt acgcccgaac cgacagaaca caagtcaata
     6721 gttatgtgat ctgagtcaca aatctattga cctgcctggt gcgggactcc agtgctcgcc
     6781 cctctcgggt cggcacaacc gaacacgtac cgtagctgac ggtcacccca aatggactat
     6841 tcgccagcgg ccaagtgggg ccatgcggtg aaaccgacat gcctaggtga tctgcttcgc
     6901 ctatcacccc cgcctgatag tcgccacacc gggttcccta tcggctaccg tgagcagcaa
     6961 tcgcgcgtga aggagcccac atgaacacgg ccggggacga cccccgaatg atcattgatc
     7021 cttcggtgtg gcaggaaccg gagacccgcg cggcgctgcg cgtccgcgac atcgggaccg
     7081 tatatcggca gctcaagcgg catggcgtct cccaacggcg gatagcggca ctcaccggac
     7141 agtcgcaacc ggaagtctcg gagatcatgc ggggccgtca ggtgatggcg tacgaggtgc
     7201 tgtcccggat cgctgacgga ctcggcgtcc cccgtgggct catgggactg gcgtacgaca
     7261 gccctcgtgt ggcttcctgt gcgggaccga cggaaggaga atccgacgtg gaacgcaggg
     7321 gctttatcgg cctggtcgcc aaggcggccg tagtgggtct cagtggcgcg gagctggaca
     7381 gcatccgggt tcttcaccag gcaaccccga tgcccggccg gatcgggcac gccgacgtga
     7441 gcaaccttga aacgacagtc cagttcttcc gtgcgcaaga cgaccaattc ggcgggggcg
     7501 ctgtcaaatc agccgtggtc ggccaccttg aatgggcgac gggaatgctg gaatccccgg
     7561 ccgccgatga cgtacgaaac cgcttgcgca ttgcgcttgc ggatatgcac tcactagcag
     7621 gctgggtatc ttttgacctg ggagcgcatg agcaggcaaa tcgccacttt gcaaacgcgc
     7681 tcgttcttgc caaagagagc aaagagcacg cgctagcctc aaaggtgttg tttcaaatgg
     7741 ggcgggttta tctccaccag aaggagccag aaaacgccct gaagattttt caactcgggc
     7801 aaatgtcggc acaggacgcc aactctcatc gggctgtggc tttgaacctt gccgtgtccg
     7861 cttgggctca cgcggagatg ggcaatgcgg agcagactaa gagtttgctt gcacatgcgt
     7921 ccggcgaact atcgcgcgac aacggacaag acatccctac ttggctaaac tttatgggtg
     7981 tcgccgagat tgaaggtatt tccggtatgg cctacacggc actatcaggc catgacaggt
     8041 catttgccga cctcggaata cagcacgctt cccgttcttt cgagatgcgc gacgagtcgg
     8101 acgcccggtc ccgcgcatcc gacctcatcg cgatagcggc aaacaacctc cgcgcgggca
     8161 acgtcacgga ggggattcgt gccgcttccg acgttcttcc gcgactcgac agcgtgcggt
     8221 cgactcggct catggatcgc ctcacgtggg tacggcaggc cacaaacctt catccgagta
     8281 gcggagaagc gcgcgagctt gccgagcgca tcaccgagct tcgctctgcc tgatacgccg
     8341 agcatatagc gccttctgat catgcggtgc ctatcggtga agtcatcccg attggctata
     8401 tcgttcacct ctcgcctatc cgttcgcgtt tgtaggagat tggttctagt cgcagtggtg
     8461 cggctgaggg cctgataccg acgcgagatc ccccgacgct cggtcttagg ccgggctggt
     8521 gaccagcccc gacacggttt cttacgtgtc gttccccttg gggctggtca ccagccaccc
     8581 atgaccgagc gaaagggcct caccatgagc gcgacggcgg ttgaaaacca cgggttgaac
     8641 gagcagacca cggagaggct gagtgagcag gagaaggccg ccgttctgta cgcggcgcac
     8701 ggatggccag tactgcccgg ctcgacgtgg aatggtcgtc gctatgtggt accggcgacg
     8761 ctcaaagtca cgaacggctt gcgtccgtgg gtggcgcgaa acctcgccag cgcggacgtt
     8821 gccacggtta ctcggtggtg gagcgcagac acacgccttg cgccgtccgt cctgttgcta
     8881 accggtgagg ctttcaacct cgtatcggtc gcattcgagc tggcgcaaga tgtgctcgca
     8941 acgacggcgt ttctcgacaa cgccgggccg gtcatgtacc ggccggacga aggtcgggcg
     9001 tattttctcc tccagccggg gccgatccag tttgacgacc tcgacattgc gcctggcgaa
     9061 gtggccaaca ttgcgcccgg caagtgggta gcggccccgc cgacccggac cggtaacggc
     9121 gtgaatgttc ggtggtggtc cacgcctgaa tccgtaaatt ggcgactgcc tgacgtcgcc
     9181 gtgctttatg aggctttggc cgtggcgtgt cgggaccgga ttaactcgtc cgcccgctag
     9241 ctagggatgc ggcatatgag cacgacacgg ccaaccaatg acgacccatg acccgatgtg
     9301 gctacaattg tcagtggtgg gtagcgctgg tgtcctgttc gtcgtggccg gaatcctcgg
     9361 gctgatcttg tggattcggc ggcatcggga gaagcgagcc aaatggttgg aacttcaaaa
     9421 cgacgtaacc gaaatcaaga cacgccgcac ccgttcggac gtcccgtctg gcaagctcag
     9481 tgttcagcaa atccgtgaca aggttcgaca gggaaacgcc gatgatccgg ctaaccgtcc
     9541 cgcccaaccc ccttcgcgca cggaggatga ctaccccacc acgcgaatac ctcgtatccg
     9601 agacgatgac ccggagcaga cagcgcgctt tgtgccccgc gtacgtccct atctcggcgt
     9661 ccgacggtgg gacaggcaat gagcggaaat gaaccggctt gacgttgaac ccgcagactc
     9721 gccccgacac tcggcatcgt tggggtgtgg aagtacaggc ggctacggcc gcgaaatcga
     9781 gaagggtagg taatagtgcc tgacatggaa tcggccgaaa tggtgggctc gggtcaactc
     9841 gtggacctgg gcgacatggc ggcgctgacc ctcggcagcg gaaggtccac gcaggaagcc
     9901 aagcgacaca tctacaactg accgaagctg acgcaacggt gcccgcctcg cacacagggg
     9961 cgggcaccgt tgcccgctct catacgaggg agacgaacgg gtgttgtggt tcggaggatt
    10021 cagcgggaag accgggccgc cacgggtacc ggtcggcgtt cggaatctgt ggccaacggt
    10081 tccgggcggc ggttggttgc atggggggtg gcctacgcac gaggtacgca ccaaacgcac
    10141 cggtcgccgt tctcttgccg tgctcggccc gtgcggcatg acgtctgacg aactggcacg
    10201 gctggcggtt cacggggtgc ccgatgacgt ggcgtggcgt tggcccggca gttacaccgt
    10261 cgtggcggcc gacgacgacg gccgaacgac gatatggacc gacgtgggcg gggcctgccc
    10321 gatctacacg ctgaccgtgg acggcggggt gtactggtcg tccagttccc gcgcgctggc
    10381 cgggttgacc ggcaaccaca ttgacccgga ctggttggca gcatggttgg cggcacgggg
    10441 cgtgtctccg ttggtggacg gacgatccgc cttcaccaac gttgccgccc tgccagccgg
    10501 tcaccgggtg tcggtgtcgg ccaacggaac cgttgacgct caacgggtgt ggtggccccg
    10561 gccccggcac gccgaccacg tggcccggct acggcacgaa ctgacggcgg ccgtagctct
    10621 ccgggtggac gtggccgagt cacctacggc cgacctgtcc ggcgggtacg actcgacaag
    10681 ccttgtcctg ttggccgccg aacggttgca ccccggccgc gcggtaaccg gcgtgaccct
    10741 gcaccctgac ggcatcacga ccgggggtga cgcctcgtat gcgcgcctag cgggtcgaat
    10801 gccgggcatt gaccaccaat ggctaccgct gggtgccgaa catcggccgt tcggtgaact
    10861 ggaccgggtg ccggtcaccg acgaaccggc accgtccgcg ctcggctacg cctcgttccg
    10921 tgcgcagctt gaatggttgc gagagcggcg cgcgtcagac tgccacatga ccggcgacgg
    10981 cggggacgcc ttgatctgta ccccggcgct gttcctggct gatcttgtgc gtacccgccg
    11041 atacggccgg gcgctggccg acgtgatgcg ttgggcgcga ctggcccggc ggtccgtgtt
    11101 cccgttgctc ggcgcggccg tgcggaccgc acgcaccacg cggacggacg cgctggacac
    11161 cgtgttgaca tccctggccg agtttggcag ccaggcggct atcggcgacg tggcatggtt
    11221 tccggccgcg tccccgccgt cgtgggccac ggacggactc cgggaacggg tggccgcctt
    11281 ggcgtcgtcg gcgatcaacg cgggccgctc gacggacggg gacgattggc cggacttcac
    11341 gacacaacac atggcgtccg tcatggcgac cacgggccgc acggcccgcg cggacgtgga
    11401 gttggccgcc tggtccggcg ttccgttgca caacccgttt ctagactccc ggctgatcga
    11461 cgtctgtttg tcggtgccgc tggccgaccg acgcggcccg gccgagtaca agccgctcat
    11521 gcgggccgcg ttcgatgatc tgttcccgga accgttgaaa cggcgtgtgt ccaaagggga
    11581 catgaccccg gactactacc aagggttgcg cgccaacctg gccgccgtta cggacatggc
    11641 agacggacgg ttggccgaac tacggctagc aagtccggcc gtgttgcggc gcatcatccc
    11701 gcttgcggcg gccggcgtcc cggccgcgta cggagcgctt gaaacggcca tctcggctga
    11761 ggtctggcta cgggcgatcg acacggcccc ggccgtgccg tgggaagctg ccaagagcat
    11821 tcgggaggcc gcgtgactcc gcgatacgtc cgcgcgccgg atcacgtcgc agcgtgcgac
    11881 ctaggcccgg caacagtgct gttggactac cggacggggg cggtcaaggt gctaaccggt
    11941 caagccgcgc gatggtgggt cgagctggcg acgaccggcg aacccgacac cccaacgacg
    12001 atggaccggg cgtccgcgcg ggcgttgctc gggcagctcc acggggcggg tctactgacg
    12061 gcggctgacc ggccccggcc ctggcccgct cccgtggccg gtcggccgct cacgccgagt
    12121 tggggaacgc agaccgtcaa cgccggacgg accccgatcc cgtccgtgcc gtaccgcgcc
    12181 ctaccgctgg cagcgctggc cttggccgtc gtcctggccg ttgaacacat cggccccgca
    12241 cggttccgca tggcccgaat cacgcaccta ctcagccggg ccacccgacg cacggtcacc
    12301 tgtgccagca ccgatcaggc acgccgtgcc gtccacgcgg tccgccgagt cggcctgttg
    12361 acaccgggcc gggtcgcctg cctagaagaa tcggccgccg tggcgctcat gctcgccgta
    12421 tcccgccaac gggtgacctg gtgtcacggt gtggcggctg atccgatatg cctacacgca
    12481 tgggtagaga ctgacgacca gcccgtagcc gaaccggaat caactcaccg atacaccgca
    12541 ctacgcacta tcccggcaca actcacagga gatggtcaaa attagcgacg caaccccgga
    12601 caccagcgca gaccgcgagc cgaccctatg gctacgcggc gagaaagcgg ccctaggtcc
    12661 gttcctacgc gatcttgtgc ccctttactg gcgttgggag accgaccccc gttccttgct
    12721 cggattcggc cagcagtacg ccgaaaccgt acaaaccagg gcgggtgtgt tcgatgctca
    12781 gtcacgcgac gggagcccgt atttcacgat ctacgatacg accggttccg agccaatccc
    12841 cgtcggcatg agtcagctta ttgtggacaa ccgcacccga accggcgagt tcatcatcct
    12901 cattggcgag gaagggcgcg gaaaaggaat cggcacggaa gcaacccggt tgactctcga
    12961 ttacggcttt cacgtcacag cgctacggaa cgtctacttg tccgtagtcg catcgaattt
    13021 cgcaggaatc cgcgcatacg aaaaagcagg attcaaggtc ataggtcggc ggcgcaactc
    13081 tggtcactgg ttcggcgaaa tcgtggacca tgtactgatg gacgccatac cggccgactt
    13141 tcccggcccg tccgtcgtca agaacatagt cggctagcca gagtctgcga gggggtactg
    13201 gatgtccacg cgcaccaagg gcggaatact cttaccaatc ctactagtgg tcggcgggta
    13261 tttcgtcgtg acggagaccg atcttggaag caagatcggg gacattttcg ccagccctgg
    13321 cggcgaaccg caaggcgtag cggtgccacc tgagttccac ggccgagtga agtcctgcac
    13381 ggcggtacaa cttgccgccg ataagcgttg tggcgacgac aaggttctac ctatagatgc
    13441 ggcaaagatg ccctatatag cccgaaatat cacactcgcc tgggaatcca ggccggaaac
    13501 ggccgcgctt acgaaggcgt cctacaagga gcgtcagaac taccgcgctt cgggatgcgg
    13561 aaggttcgcc cgaaccatcc ggtccgacga cccgaaaaag gctgggtcgt gcgacgagtt
    13621 ccccttcaaa tcaaccgaag aaggcgggac gggttcgcgg atcgaagaag tcccgaccgg
    13681 agagcagaac atacaaggcg gcacgatcag ctcattctat cagaaacaca agatggttga
    13741 cggcgataag tacctggtcg tcatcataaa tccagcgtcc atagcgaccg ggccatacga
    13801 aggatgacca tgcttgacac tgcgacctac cagtggatca acgatgaacg gtactcggct
    13861 atcacactgg cgattgtcgc cgggactgcc gaggatgacg ttatccgcgc atacggtggc
    13921 acccctgaaa catcggagat agcgacgttt gacgagtcct tcaactcgtt tgacgacggt
    13981 cagccgttcc atgtgcagac cttcacgact ggccagttcg ttgtggctgt cgaaaacaac
    14041 gggtttcacg gaagtgattc ccggatcgcc cggaaggtga ccggggaatc cgggcggttc
    14101 atcagcgtca agtggagttc cacggggggc gactacatcc tttacgtggt cggccacaag
    14161 atcgaagccc agttcgacgc gctgtcggtc tcgctcggcg gcgacgggga tgggatcgtg
    14221 ccggagtggg tcaaccgtgt tgactggtcg caggacgaga cccgagcgcc gtacctggcc
    14281 ctgttgggag acgtgatggg tgtgcacgtc agccaagagt ggttcaccac gcctcaccga
    14341 acgaccgtca ttcccgagct atacagcatg gcggatctct agcccgtcgc tcgtgtgtcc
    14401 gggccgcaag cagccgcgaa ccgctccccg ctcgacgcgg ccgggagcgg ttcgggcgag
    14461 aatccccagg tcacgagaca gtaactaaat gcgggttcgc ttgcgcgatt cggtacagcg
    14521 cgacgtccag cgattccggc aaccgcggcg gtgtgccccg cagggtcagg cgggcggcga
    14581 ccccggccgc gcggacccgg tccaccaggt ccccgatgcc gtgcaggccc ggctggcgct
    14641 gcgagtcgtc gatgtcctga ccgtgcagca ggtcgagcat ccggcgcaac tccaccatcg
    14701 ccgcgcggct ggccgactcg acctcgctca gcgactgccc cgcctgcgtc gggccggtgc
    14761 cgttcaggct catcctggcc accccggcgt gcatggcgat ggcgctgacg tagtgcgaga
    14821 tcacgtcgtg caggtcgcgg gccaccgcgc cgcgctcctc ggcgaccgcc cgccgcaccg
    14881 ccgcgcgctc gtcccgccgg gccagctccg cctcggccgc caggcccgcc aggtacgtct
    14941 gcctggtcgt ggtggcccgg ccgaccagcc acggcagcac caccagaccc agcgcgagcc
    15001 ccagcaacgc gggccaccgg tggaccaccc agtccccggc gaccaggtgc ctgcccagct
    15061 cgccgagaat cagcgtggcg aacaccgcga ccgcccacct gccccgcagc cacgcgcccg
    15121 cctggtaggt cgccacggcg aacccgaaac tgcccgccac ccgcgtcccg gcgccatgcg
    15181 cccagagcag ggcctccagc agccccagcg tggcctggcc gatcgcgacc gcgccgctgt
    15241 ggcgcaccga cgcgaccagc gccagatccg ccagcacgat cgcgccgtgc agcgcccacc
    15301 cctgccagcc ccagtcgacg gaggcgcgca gggccagata cagcgccgag tccgcgacca
    15361 gacacacccc agccaccagc agcgactgcc gcgtcaacga tccccgcaca tccggcacgc
    15421 gccgactatg gcagccgtgc ccgcgccagg aaagggcaga ctacccattt ccgccggtcc
    15481 accacgcgcg tgggcggcgc tcggcatact cgggtcgacc cacaccaagg cgcactaacc
    15541 agagagaccg cagtggagaa gtatgccttc aagtaggccg ccgagcgccg ttttcacggc
    15601 acgctcgccg agatcctgaa cgacatgctc gccaggctgg acatgcggcc gaccgtcgaa
    15661 ccacacacgg cgtggtcacg atcgtcaggc tgcacgagac catgctcgaa caggcgatcc
    15721 tcgacgaact acccaacacg gccgacaacc gctacctcac gcaggtgctc ccccgcctgc
    15781 tgacaaccct ggtcgcaccg agcaacggct gaccgcgatc cgcccattgt tccggcaggt
    15841 ggcgcatggc tccggtcggc agatcgtgca ggacgaccag gctccatggt ccgcgacgaa
    15901 tgtcgttgac ggcgcgttgc acccagtcgt cggcttggtt gcccgttttg ttgatcgcga
    15961 cgatcgtggt gaacggttcc tggttgaggt aggcgggggc cggcttgccg tccttggtgg
    16021 gggttttggt ttgtttgaag tggcaggtga aagtgaccgg aacgccgtcg tggacggcgt
    16081 ccaccgtcca tcgggcgtcc tgagtggacc attcggcgcg gatcacccgg tggccgcagc
    16141 ggatgtgccg gtcgatgcct tcctcggcgg cggtgtcgcg cacgtaccgc aggatggacg
    16201 gcccgtcggc gatcgacttc ggattcgtcc acggccggaa ccggtagccg agggtgttca
    16261 tgtccgagtc ggaccggatg cccgggtagc ggaacaggtc ccaggtgccg ccgatcgccg
    16321 cacgggcctc caggatcgtg tagctacggc ggggaaacgc ctcctggata tggcgcgccg
    16381 cgccgatgcc ggacagcccg gccccgacga tcaggacgtc gacgtgctcg gtcgtggtca
    16441 tcagttcacc ttcccggcgc ggtcgcgcaa ccgattccgc agcaggccaa gcacggcgta
    16501 gtaatgcgtg ggggaaatcc gggagagcgc gtcgaacaga tacgcgtccg ggccgacgag
    16561 aatgcgggcc ttgccgcgtt cgacgcccgc cacgatgatt cgcgcggctt tgtccggcga
    16621 ggtcagcgtg accgcctcga attgggcggc catctgttcc ctggtccggc cgaggccctc
    16681 ggggtcttcg cgcatacgag cgttgcggac gatgttggtg gtgatgccgc cggggtggac
    16741 ggtgatggcg cggacaccgg tgccgcgtag ttcctgccgc agcgcgtcgg tgaagccgcg
    16801 gacggcgaat ttcgcggcgc agtaggcact ctggtaaggc ataccgacca ggccgaacac
    16861 gctggaggtg ttgacgatcg cgccgctgcc ctgggcggcg aggatcggca ggaacgcgcg
    16921 ggtgccgttg accacgccgt ggaagttgat gtcccacagc cactggtcgt cctccggcac
    16981 ggcgttgagc acggtcgagg cgaccgcgac gcccgcgttg ttgaagaccg cggccagcgg
    17041 cgcgggcagc cagtcgcgga cttcggcggc gaaccggagt tggtcgtcgg cgtcgcggac
    17101 gtcgaggacc cgcgtgagca ccgggcctcg caacgattcg gcggtctcct tcaggccgac
    17161 cggtcgatgt cggcgatcgc caccggcgag cccgacttcg acaggcgctg ggccaagccg
    17221 cggccgatgc cggacgcggc gccggtgacc acgaccggcc tgccgccgat ctcacgggac
    17281 ggttggggca tcgtcgctcc ttgactgagt gggctccgcg gacgtggcgg tcgatgagga
    17341 gccgggattc gcgcgggcgg tggcgccacc accggtcggg ttgaccatcc ggtcgcggtc
    17401 gccgtggatc accaaggtcg gcgcggcgat cgcggccagt cgtgcggtcc ggtcaccgga
    17461 cttgacgatc gcggcgagct ggcgggccac cccctggccc gagggatcgc gttcccaggc
    17521 cagttcggcg caggcgcgga ccgccgggaa cccgtgcgag ccgatgtgcc ggtacatccc
    17581 caccaaccga tcggcgtgag cctgccgggt cgccggtggc cgaccgccca tgcgccgcaa
    17641 agccgaccag gcgggcctgc cgacccggcg ggccccggtg gtcgacatga tcgacgtcag
    17701 cgtccgcact cgcgccggag tcagcgcggc gacggtctgc gcgatcatgc cgcccatgga
    17761 cacgccgacc aggtggacgt cggcgaagcc gagcgcgtcg atcaggccca cggtgtcacc
    17821 cgccatgtcg gtcaggtcgt attaccccgg cgaccagcgc ctggccaggt ggcggcgggc
    17881 caaggcggcg ggaatgccgc gtgggtcgac cggcccacgt cgcggttgtc gaaccggatc
    17941 acctggtagc cgcggtcggc caatcccgcg cggaagccgg tcggccacgc gtgcagtcgc
    18001 tggcccagcc cggcgacgag cagcagcggg tcggctccag ggtcgccgat ccgttcccaa
    18061 cacagcgcga tgcccggccc gacatcggtg atctgctcgg tcatgcccgg cctccggtcg
    18121 ccgcgaccga ctgaggcgcc tgcctgccgg tccgcctgcg cacgaccgcc cgcccgcccc
    18181 ggcccggcgc gtacgcgatg ccgcggaact gccagcgctc gtctcgatcg gcggtcggca
    18241 ccagggtcac ctcgcgcaag atggtgcgca gcacgatgtt catctccatg gtggcgaacg
    18301 cggcgccgat gcaccgccga tggccgccgc cgaacggaac ccattggtac agatcgggtt
    18361 tcgtgccgac gaagcgggtg gggtcgaagc ggtgggcgtc cgggaagacg gcgtcgtcct
    18421 cgtggatgag cgcgatgctg gcgaacaccg agtgcccctt gggcaccgtc caccgcccca
    18481 gcgtcatgct gtcggccttc acctggcgca gcgtctgcgt gatcaccggc cgggtccgca
    18541 gcacctccag cagggttgcc tcccgcagcg tgctgccgcc cgcgtcgacc tcgtccacca
    18601 ggtcgcgcag cacggtggga tggcgacgca gccgctcgac gacccaggcc agggtcgtcg
    18661 cggtcgtctc gtggcccgcg gccagcatgg tgatcagctc gtcggcgatg tcgccgcgcg
    18721 tcatggccga gccgtcctcg tagcggctcc gcaccagcag cgcgagcacg tcgtcgcgct
    18781 cgtccagccg ctggtcggcc tcggctcggg tgatcatccg gtcgatgatc tcgccgtact
    18841 cgcagcgcaa cgcgtccaac cgcgcccagg gcgaccaccg gcccaggttg accgagggcc
    18901 tgggcagcag cgccagccgg gaccccaagg tcaccgcccg cggcagcagt tcgcgcaggt
    18961 gggcgaactc ggccccgtcc gcgccgaaca ccgcccgcag gatgatgttg agggtgatcc
    19021 gcatcatcga cggctgggac gcgaacgcga cgttttccgg ccaggacgcc agttcgcgga
    19081 gggtttcctc ctcgacgatc gcctcgtacg cgcgcagccg cctgccgtga aacggcggga
    19141 ccagcagctt gcgctgcgcg cggtgctcgg cgccggaaag ggcgaacagc gagccggggc
    19201 cgagcacgcg tccgagattc atcacgtcgt ggtagtccgc gacgtcagcg ggtgtctgga
    19261 aaagctgccg gacctcggcc ggtgcgctga cgaccaccgt ggggccgagg atcggcatcc
    19321 agagggtgaa cgcgtcgccg tagcggtcgc gcaggcggcg catcgtgcgg cgcccgcccg
    19381 ccatcacggc catgccctgg atgagattgg ggacggatgg tccgggcgga agcgtcgtcg
    19441 tcgccattga gcagttaccc ttctcgcctt tggtacgtcg atgtaccgcc ggatggtacg
    19501 ccgacatacc aagcggcgca atgatctcgc gccccggccg gtatatggtg gtggccgtga
    19561 cagcgacgcg gcgtgggcag gccgaacccg cctcgtccgg cgaggcgagc gcgttccgca
    19621 ggcgcctgct cgacgggctg gccgagtcca tcgcggcggt cggctaccgc aacacgaccg
    19681 tcgccgacat cgtgcgccgc gcccgcacgt cccggcgcac gttctacgag cacttcgcca
    19741 gccgcgaagc ctgcctgctc gcactggtcg cggacagcac cgcccagacc atcgggcaga
    19801 tcgtggccgc cgtcgacccg acccggccct gggaacacca ggtgcggcag gccatcgaag
    19861 cctggatcac ccgggtggag agcgaaccgg aactgatcgt gagctggatc cgcgacgtgc
    19921 ccacactcgg cgacgtggcc cgccaactgc agcacgacac catggaagcg ttcatcacca
    19981 tggtccgcac gctcgccgac accgacgaat ggcgcgccgc ccacggcgac cccccatccc
    20041 gcgagatggc gataatcctg ctcggcggcc tgcgcgaact gatcgccagc accgtcgaaa
    20101 acggcggccg cgtccgcgac atcaccgaaa ccgccgtccg ggccgcgatc gtcctaggcc
    20161 gcgcctcagc gctgtgaccg gaagtcactt acctcgggac agtccacact cccaggcgtg
    20221 cggaacagct cggccaaggg tggccgcatc ggatctccta gggccgtgtc tcaaagttgt
    20281 cgtagccaga tggtgatggc ggcgatgtgg atggcggcgt tgtggatggt ggcggtgtag
    20341 cgcacggcga gcttgtcgta tcgggtggcg acggctcggt gttgtgtgag ctggtcgatg
    20401 ccgcattcca ccgcgtggcg ctgctcgcag gcgtcgcggt cgaagaccgg tggacgcccg
    20461 ccgccgcgac ctttgccgcg gcggtggaac gacagcggtt tgcggccctg ctcgcacgcc
    20521 aagtgcagct tgccgtccag ccaccgcgcg accggcccaa cccctgatca ccgggctccg
    20581 cgccgccagc cgtggtgtcg gccggttcgg cctgatgtgc tggcgcgcct cgatgtggga
    20641 ctcgatcttc tggtgggctc accgacccgc cgcgaccgtc gtgcccgtgg tcaagcccgg
    20701 gcggcagggg cgggtgcgcc tccaggctat tttgtggccg tggtgatcgg caccgagagc
    20761 gttcgtcgga taggtcggcc gatcgctggc cctgtcttcc gccttcgagg agcaccatga
    20821 ccgctaccta caccttcgac gtcttctcca gcctcgacgg ctacgcctcc tacaacagcg
    20881 acggggactg gggcggctac tggggcaagc aaggtcccga gtttctcgac caccgcctcg
    20941 ctttgtaccg cgagaagcag cggatggtcc tcggggccaa cacctttcgg cagttcgtgc
    21001 agatgctggg cccgcgcacc ggggaactga aggaactcga cccggtgaac acgcagatga
    21061 ggaacatgcc gacaacagtg gtgtcgacga cgctcgaagg accccttgac tggccggacg
    21121 ccactctggt gagcggtgac gccctcgacg tcgtcgcccg gctcaaggag gaatccgatg
    21181 tgccgctgcg ctcgcacggc agcctgtcga tgaaccgggc gctgatggcc gctggtctgg
    21241 tcgatcgcgt ccagctgaca atcttccccg tgatcaccgg tctcaccggg gtggagccgg
    21301 tcttcaagga tgcggcggac ttcgacctcg agctgatcga gagccggacg ctcgacggtc
    21361 acatccaaga gctcatctac cggcccaccc tgcacgcctg agtcaatccc cgcgagccgc
    21421 acggcgacgg cctccggggg cgcagcccgg tccgccgcgc ggcggcggcc gaaggcgaag
    21481 cggttcgtcc acgactggac cgcggacctg gtgcggcgcg ctgtctgact cttcgagagc
    21541 ggctgggcag ggcggcaccc gcggcgggtg gttgcggccc gggtgggcgc gccgtggccg
    21601 acggtgttcg ggggcaggct cgaccagcca tggccaccgg gtcctgaccc gccgctcccc
    21661 gactgggacg agattcgcgc ctggcggccc gggtgaccat caccgtggac cggaccgaaa
    21721 gcctgggcgg acgcggcaca cgccatctgc cgtggggtcc tcggtcctgt ccggcgcgtt
    21781 ccttggactc tgccgcggtc ttggccgctg ggggcagcct ggggtgacgc gatcgaaagg
    21841 aaggctgtca tgggccgctc acatcctgac caccagaccg ttctcgacgc ggtgggcctg
    21901 gcctgccggg ctccgtcggt gcacaacacg cagccgtggc ggtggctgct cggggaccgc
    21961 tcggtccacc tgatggccga ctggactcgg caggtcccgg cgaccgaccc ggacggccgc
    22021 gacctgctgg tcagctgcgg cgccgcgctg caccacctgc gggtggcctt cgccgccctg
    22081 ggctgggaca cggaaacggt cctggcgccc aaccccgccg accccgacca cttggccgcg
    22141 gtcgagccac accggcacac cccggacgac gatgaggtgg cgctggcggc ggcggtcacc
    22201 cgtaggcgca ccgaccggcg gcggtactcg tcctggccgg ttcccgacgg gcacatcgac
    22261 ctgctcgtcg agcacgccgc ggcccacgac gtggtggcgg tgccggtgac cgacccgttc
    22321 gaccggcacc ggctggccca ggccatcgcc atggcggcga tcgcccagga agacgacccg
    22381 gcgtaccgcg ccgaactcgc ggtgtgggcc gggcgcggca ggggaagcca cgagggcgtg
    22441 cccgcggcgg acacaccccg ctggccggtc acgcacgacg gcatccggat gcgcgagttc
    22501 cccggcggca cactcacggt cgcgccgacc ggtgaaaccg acgccgccca actgctcgtg
    22561 ctggccaccg ccgacgacag cgtcg
//
