LOCUS       NZ_FMZZ01000001        12292 bp    DNA     linear   CON 09-DEC-2024
DEFINITION  Actinokineospora iranica strain IBRC-M 10403, whole genome shotgun
            sequence.
ACCESSION   NZ_FMZZ01000001
VERSION     NZ_FMZZ01000001.1
KEYWORDS    WGS; RefSeq.
SOURCE      Actinokineospora iranica
  ORGANISM  Actinokineospora iranica
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Pseudonocardiales; Pseudonocardiaceae; Actinokineospora.
REFERENCE   1
  AUTHORS   Varghese,N. and Submissions,S.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-OCT-2016) DOE - JOINT GENOME INSTITUTE, LBNL, 2800
            Mitchell Drive, Walnut Creek, CA 94598, 94598, USA
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_900101685.1-RS_2024_12_09
            Annotation Date                   :: 12/09/2024 15:26:45
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.9
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,202
            CDSs (total)                      :: 6,139
            Genes (coding)                    :: 6,038
            CDSs (with protein)               :: 6,038
            Genes (RNA)                       :: 63
            rRNAs                             :: 3, 4, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 3 (5S)
            partial rRNAs                     :: 4, 4 (16S, 23S)
            tRNAs                             :: 49
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 103
            CDSs (without protein)            :: 101
            Pseudo Genes (ambiguous residues) :: 0 of 103
            Pseudo Genes (frameshifted)       :: 25 of 103
            Pseudo Genes (incomplete)         :: 89 of 103
            Pseudo Genes (internal stop)      :: 7 of 103
            Pseudo Genes (multiple problems)  :: 18 of 103
            CRISPR Arrays                     :: 3
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 18:38:36
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 356609
            Orig. end                         :: 368901
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            FMZZ01000001.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..12292
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="3"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..12292
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..12292
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:7292](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..7292)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     misc_feature    complement(559..573)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.73"
                     /tool="antismash"
     gene            577..822
                     /locus_tag="BLS56_RS01680"
                     /old_locus_tag="SAMN05216174_101341"
     CDS             577..822
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="BLS56_RS01680"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="SAMN05216174_101341"
                     /product="hypothetical protein"
                     /protein_id="WP_228771275.1"
                     /transl_table=11
                     /translation="MSELQSKNFTAPDEVRPFPDHGHVDLVNLDSRPVGLGTFEAGWRW
                     SNDVKPLAGTDSCQVEHIGYVLSGRMKVVMDDGRES"
     gene            complement(1008..1682)
                     /locus_tag="BLS56_RS01685"
                     /old_locus_tag="SAMN05216174_101342"
     CDS             complement(1008..1682)
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018686454.1"
                     /locus_tag="BLS56_RS01685"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216174_101342"
                     /product="response regulator"
                     /protein_id="WP_091447425.1"
                     /transl_table=11
                     /translation="MISVLVVEDNPVAADAHRHYVERVPGFRVAGVVHSGRDALRFLDA
                     TTVDLVLLDLYLPDGHGLDVVRALRAAGRTADVITVTSARDLAIVRAAVSAGVVQYLLK
                     PFTFATLRDKLNGYAKFRARVSGHGEAAGQAEVDEAFGALRSTENLALPKGMSRQTLDA
                     VIEAVRTSDGGLSSGAAADAVGVSRVTARRYLEYLADTGLAARRPQYGAVGRPEVWYRW
                     AG"
     gene            complement(1679..3286)
                     /locus_tag="BLS56_RS01690"
                     /old_locus_tag="SAMN05216174_101343"
     CDS             complement(1679..3286)
                     /EC_number="2.7.13.3"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1003: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004558784.1"
                     /locus_tag="BLS56_RS01690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216174_101343"
                     /product="sensor histidine kinase"
                     /protein_id="WP_091447427.1"
                     /transl_table=11
                     /translation="MTGRRQWSLAHQLLVLQVVIVGVLVTGGAILVWVDVADRAEESSA
                     ATVRTLARAIADSPSVVEAVTGPDPSGVLQPYAHAVLADTGVDFITIMDVEGLRYTHPN
                     SAMIGKKFLGNTDAALAGQAFTEIYEGTLGPSVRAVVPVFDVERRVVALVSAGITLSAI
                     NEQVAERVIPLIGVALLALAVGGLGTYLVSRRLRRQTGGLAPAQLTRMIEYHESILHAV
                     REGLVLVDSQHRVTLCNDGVRALLDLPADAEGRPVTELGLPDGLVQRLLSGIEMRDELH
                     LTDTRVLVVNSSTVRFDGRVLGTVVTVRDRTDLQALTGELDTVRGFAESLRSQAHEAAN
                     RLHTVVSLVELGRATEAVEFATGELAIAQRLTDQVVAAVSEPILAALLLGKAADASERG
                     VELLVSPDTEIADYALNDEGPVTPRDLVTILGNLIDNAVDAAVEGAEAHRPLVEVSAKT
                     SPRELVLRVADSGPGIPPSALDDAFRRGWSTKGGAGRGLGLALVGQAVRRAGGTIDVGR
                     DVGAVFTVRLPVRMGERG"
     misc_feature    complement(2765..2767)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(2807..2809)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            3413..4816
                     /locus_tag="BLS56_RS01695"
                     /old_locus_tag="SAMN05216174_101344"
     CDS             3413..4816
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0015293 - symporter activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1212:
                     sodium:dicarboxylate symporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005457918.1"
                     /locus_tag="BLS56_RS01695"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216174_101344"
                     /product="cation:dicarboxylate symporter family
                     transporter"
                     /protein_id="WP_091447429.1"
                     /transl_table=11
                     /translation="MSTTKSPRQDRTRYLYLAVIVAVVLGVGVGLLFPSAGSALKPLGT
                     GFVALIKMMISPIIFCTIVLGVGAVAKAKAVGKVGGLALGYFLVMSTIALVIGLVVGNL
                     LHPGDGLQITEAARASGEEQAAQGSESTIEFVLGIIPTTLVSAFTEGEVLQTLLVALLV
                     GFGLQTMGPKAEPVLRGVGHLQRLVFRVLAMIMWVAPVGAFGAIAAVVGETGVAALRSL
                     AVIMLGFYATCVVFVVAVLGLLLWAVARVNLFALLRYLSREFLLILSTSSSEVALPRLI
                     AKMEHLGVSRTVVGITVPTGYSFNLDGTAIYLTMATLFVANATGAPLSLGEQVSLLLFM
                     VIAAKGAAGVTGAGLATLAGGLQSHRPDLVDGVGLIVGIDRFMSEARALTNFAGNAVAT
                     VLIGTWTKQFDRGRAGLVLTGQAPFDEATLTDDHSPSQNTAPVPGPVAIPRQRRLHGQP
                     ISEDQQPKT"
     gene            complement(5001..7292)
                     /locus_tag="BLS56_RS01700"
                     /old_locus_tag="SAMN05216174_101345"
     CDS             complement(5001..7292)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: YcaO"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF014661.5"
                     /locus_tag="BLS56_RS01700"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216174_101345"
                     /product="YcaO-like family protein"
                     /protein_id="WP_091447432.1"
                     /sec_met_domain="YcaO (E-value: 5.7e-59, bitscore: 196.5,
                     seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGFDSTPVRAAEPACLETAALVRDRLRQEFGDEVAVFASPGRPLA
                     PIVRLAVAVGESREFARWARTANLRALTVVPGDDTAPDTAPDTVLVGPLAIPGEPGCAE
                     CARARRVAAAARKATSPVCSSGTGVTAAPGVLKPAIAPARASDPSAEDTRRLAPVIAAG
                     VSPAKAPVTVADDTMRLAPGGADPASGARQAASVAPENARNPARPPDDAEDTTRVDAAV
                     AGGAGKPAAAASGASARMPHSGPEDMRGSAGAQARESSAESSPVLDTAGAERGGAAGRA
                     LDQIVGLVRDILRADARDLIGHVAEVGGAEPVWHRVIPLPACDVCGGATGDSAVALPEE
                     GEDDDPAALLAALAGWVDPVTGVVPWIELRQPLGESGPHTATAASPHLLDADGVPRALP
                     IGWGKGMTRSAAIRSAVGEAIERYSASLPDSDRLAWARPADLDGEILDPREFALYEPEQ
                     YAAAGFPCVPFDRRVDHPWVRGAWLGTDTPVWVPAVFAYLAMTVLPEHVICQGTSNGLA
                     AGADIDTAAVRATLELVERDAMMAAWLTGERGRFVELDETLDDDVHAVIEALQAQGPSV
                     EVYLLPTSTYGATAVALAIGDGRRWPGVALGLGADRSPRAAIRAAVLELAQTAPHLAAL
                     LRERAHPVPARPQGVREMLDHAAYYFPVERVDAFDRLRCGGTSRLRDLREPALDTSLTD
                     LAGTLGAAGVRVAVVDVTSADVATGPLRVVRAVSPDLQPLSYGHGNDRALVARLRRRGV
                     RTRALIHPVW"
     gene            complement(7282..7455)
                     /locus_tag="BLS56_RS31160"
                     /old_locus_tag="SAMN05216174_101346"
     CDS             complement(7282..7455)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="BLS56_RS31160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="SAMN05216174_101346"
                     /product="hypothetical protein"
                     /protein_id="WP_175482609.1"
                     /transl_table=11
                     /translation="MPDPRRLDARVPPPRRALPARLSGHGVDAMRGRVNQVWAGGRPVE
                     RTAEKIGSARGV"
     gene            complement(7557..10409)
                     /gene="uvrA"
                     /locus_tag="BLS56_RS01705"
                     /old_locus_tag="SAMN05216174_101347"
     CDS             complement(7557..10409)
                     /EC_number="3.1.25.-"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_process="GO:0006289 - nucleotide-excision repair
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="uvrA"
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018686461.1"
                     /locus_tag="BLS56_RS01705"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216174_101347"
                     /product="excinuclease ABC subunit UvrA"
                     /protein_id="WP_091447435.1"
                     /transl_table=11
                     /translation="MADRLVVRGAREHNLRGVDIDLPRDSLIVFTGLSGSGKSSLAFDT
                     IFAEGQRRYVESLSAYARQFLGQMDKPDVDFIEGLSPAVSIDQKSTSRNPRSTVGTITE
                     VYDYLRLLYARAGKPHCPTCGEPISKQTPQQIVDQVLAMENGVRFQVLAPVIRGRKGEY
                     VDLFASLQTQGYSRALVDGTAYSLADPPKLKKQEKHHIAVIVDRLAVKASSKQRLTDSV
                     ETALRLADGLVELDFVDLPENDPHRVRGFSENLACPKGHALGLEDLEPRSFSFNSPYGA
                     CPECTGIGVKKEVDPELVVPDDELSLADGAIAPWAGGQTAEYFVRLLTSLSEALGFRMD
                     TPWRRLPAKAQKAVLHGVNEQVHVRYKNRYGRERSYYAAYEGVIPFLERRQEQTDSEYM
                     REKYEGYMREVPCPACRGSRLKPEILAVTLEHAEHGDKSIAEVSAMSIGECSAFLDGLT
                     LGKREAMIAGAVLKEIQARLRFLLDVGLDYLSLDRASATLSGGEAQRIRLATQIGSGLV
                     GVLYVLDEPSIGLHQRDNHRLIETLTRLRNLGNTLIVVEHDEDTIRASDWVVDIGPGAG
                     EHGGKVVHSGTFKELLKNKDSLTGAYLAGRSEIPMPAVRRGIDKKRQLTVVGAREHNLR
                     GIDVAFPLGALVAVTGVSGSGKSTLVNDILATVLANKLNGARQVPGRHTRVKGLEHVDK
                     LVQVDQSPIGRTPRSNAATYTGVFDHMRKLFASTTEAKVRGYLPGRFSFNVKGGRCEAC
                     AGDGTIKIEMNFLPDVYVPCEVCKGARYNRETLEVHYKGKTIAEVLDMPIEEAAEFFEP
                     IKAIHRHLKTLVDVGLGYVRLGQPAPTLSGGEAQRVKLASELQKRSTGRTVYILDEPTT
                     GLHFEDIRKLLGVINGLVDKGNTVIVIEHNLDVIKTADWIIDMGPEGGSGGGMVVAEGT
                     PEDVVKSEGSYTGEFLAHVM"
     misc_feature    10394..10408
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.8"
                     /tool="antismash"
     gene            10873..>11553
                     /locus_tag="BLS56_RS31965"
                     /old_locus_tag="SAMN05216174_101348"
                     /pseudo=""
     CDS             10873..>11553
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:TIGR03083.1"
                     /locus_tag="BLS56_RS31965"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216174_101348"
                     /product="maleylpyruvate isomerase N-terminal
                     domain-containing protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MSGSGTAANASVGQPTLPGQRRSSGAARAATGHQAVREAWVVLRQ
                     RVAGLGDDDFAGPSKLPGWTRGHVVSHLARNADALVNLLTWARTGIEHAAYASRADRDA
                     DIEAGADRLPQVIREDLYAACDRFHTAITRLGDSDWDNKIMHPSGRWFPAAEVPELALF
                     EAWNHMVDLDAGVTFDDVPVAHLDRLLDLAVRPHRARTDGESLRLAANLPDGRQRTWEL
                     AIATP"
     misc_feature    complement(12116..12129)
                     /note="TFBS match to PsrA, Oleic acid responsive regulator,
                     confidence: weak, score: 18.03"
                     /tool="antismash"
ORIGIN
        1 ttgaacagcc gcgacctcgc tgatattccc agtgtggagg tgatcagccg ggccgcggtc
       61 atgctcatgt ccgccgccgc cgagcgcctt gggctggctg atcccgatcc ggacagcagc
      121 ccgcatcggg acttggacga ggctcggcgg ctgatcaccg ccttggctgg gctggtgacg
      181 gcgtcggtgg agtacctggg gccacatgcc gcgccgatcc gggatgggtt gcagtcgctg
      241 cagaaggcgt tccgggagtc gtcggcgttt ccggatgagc ctgggcaggg gcctggggag
      301 aagtacacgg ggccggtgtt ctgagaccgc ttgccgctct ggtggtccga ctgctccggg
      361 ttggctcgat ggggtggagt ggtttcctca gggtggtttc gcttgggcgt gctctggcgg
      421 gtggggtttg accacagtgg acacgcgggg tagcggggcg taccgagcag aactgcccta
      481 gtcggaggcg ctggccgtta ttaccgtgcc tgttctggtg tcagcgcggc tgaagggggt
      541 cgccggattt cctcacagtg gaagcgagtg ccacagatga gcgagttgca gagcaagaac
      601 ttcacagcac ctgatgaggt ccgcccgttc cccgaccacg gtcacgtgga cttggtgaat
      661 ctggacagta gaccggtggg cctcgggacg ttcgaggcgg gctggcggtg gtcgaacgat
      721 gtgaagccgt tggcgggcac ggacagctgc caggtggagc acatcggcta tgtgttgtcc
      781 gggcggatga aggtggtcat ggacgatggc agggaaagtt aggtggggcc cggtgacgcg
      841 gtccacattc cgcccggtca cgacgcgtgg acccttggtg acgaggattg cacgattatc
      901 gacttcggtg gtttgaaggg gtacgccaag ccgcctggtg aataggcagt gggctgtcgc
      961 gcccgccggg tgagggcctg gcgggcgctg cccattggac gtgggggtca gcctgcccag
     1021 cggtaccaga cctcgggcct gcccacggcg ccgtattggg ggcgccgggc ggccaaaccg
     1081 gtgtccgcca ggtattccag gtatcggcgg gcggtgacgc gggagacgcc taccgcgtcg
     1141 gccgcggcgc cggaggacag gccgccgtcg gaggtgcgga cggcttcgat gacggcgtcc
     1201 agggtttgcc tgctcattcc cttggggagg gccaggttct cggtgctgcg gagagcgccg
     1261 aaggcctcgt ccacctccgc ctggcccgcc gcttcgccgt ggccgctgac gcgggcgcgg
     1321 aacttggcgt agccgttgag cttgtcgcgc agggtggcga aggtgaaggg cttgaggagg
     1381 tactggacga cgcccgcgga gacggccgcg cggacgatcg ccaggtctct ggccgaggtc
     1441 accgtgatca cgtccgcggt gcggcccgcg gcgcgcaggg cgcggacgac gtcgaggccg
     1501 tggccgtcgg ggaggtacag gtccagcagc accaggtcga cggtggtcgc gtcgaggaag
     1561 cgcagcgcgt cgcggccgga gtggaccaca cccgcgaccc ggaagccggg cacccgttcg
     1621 acgtagtgcc ggtgggcgtc cgccgccacc gggttgtcct ccaccaccag gacactgatc
     1681 acccgcgctc ccccatccgc accggcagcc gcacggtgaa caccgcgccg acatcgcggc
     1741 cgacatcgat cgtgccacct gcccgccgga cggcttgacc caccagggcc aatccgaggc
     1801 cccggcccgc gccgcccttg gtcgaccagc cgcggcggaa ggcgtcgtcc agggcggacg
     1861 gcggtatgcc gggaccggaa tcggcgacgc gcagcacgag ttcgcggggg ctggtcttcg
     1921 cggagacctc gaccaggggg cggtgcgcct ccgcgccctc gacggcggcg tcgacggcgt
     1981 tgtcgatcag gttgccgagg atggtgacca ggtcgcgcgg ggtcaccggg ccctcgtcgt
     2041 tgagggcgta gtcggcgatc tcggtgtcgg ggctgaccag caactccacc ccgcgctcgc
     2101 tggcgtcggc cgccttgccc agcagcagcg cggccaggat cggctcggac accgcggcga
     2161 cgacctggtc ggtgagccgc tgcgcgatgg ccaactcgcc ggtggcgaac tcgacggcct
     2221 cggtggcgcg gccgagttcg accagcgaga ccacggtgtg caggcggttg gccgcctcgt
     2281 gcgcctgcga gcgcagcgac tcggcgaagc cgcgcacggt gtccagctcg ccggtgagcg
     2341 cttgcaggtc ggtgcggtca cggacggtca ccactgtgcc caggacgcgg ccgtcgaacc
     2401 gcacggtgga tgagttgacg accaggactc gggtgtcggt caggtgcagc tcgtcgcgca
     2461 tctctatgcc cgagagcagc cgctggacca gcccgtccgg cagcccgagc tcggtgaccg
     2521 gacgaccctc cgcgtcggcg ggcaggtcca gcagcgcccg cacgccgtcg ttgcagaggg
     2581 tgacccggtg ctgggaatcg accagcacca ggccctcacg gacggcgtgc aggatcgact
     2641 cgtggtactc gatcatccgg gtcagctggg ccggggcgag gccgccggtc tgcctgcgca
     2701 gccgcctgct gaccaggtag gtccccagcc cgccgaccgc cagcgccagg agcgcgacgc
     2761 cgattaaagg gatcacccgc tcggccacct gctcgttgat cgccgataac gtgattcccg
     2821 cgctgaccag ggccaccact cggcgctcca cgtcgaacac cgggacaacc gcgcggaccg
     2881 acggccccag ggtgccttcg tagatctcgg tgaacgcctg gcccgccagg gccgcgtcgg
     2941 tgttgcccag gaacttcttg ccgatcatgg cggagttcgg gtgggtgtag cggaggccct
     3001 ccacgtccat gatcgtgatg aagtcgacgc cggtgtcggc cagcacggcg tgcgcgtagg
     3061 gctgcagcac gccgctgggg tccgggccgg tgacggcctc gacgaccgac ggcgagtccg
     3121 cgatggccct ggccagcgtc cgcacggtgg ccgcgctgga ctcctcggcc cggtccgcga
     3181 cgtcgaccca gaccaggatc gcgccgccgg tcaccagcac accgacgatc accacctgga
     3241 gcaccaagag ctggtgggcc aaactccact gtctgcgacc ggtcatgccg gtaagtgtga
     3301 cggccgacgc ccatgaacgt aatgaacgca atcgtgaccg gggccacagc ggtccaggag
     3361 actcggcggc gatccgggat cgcggtgtcg cggtcccctc cccggaggcc cagtgtcgac
     3421 taccaagtcc ccacgccagg atcggacccg ctacctctat ctcgccgtca tcgtcgcggt
     3481 cgtcctcggc gtcggcgtcg gcctgctctt cccctcggca ggctcggcgc tcaagccgct
     3541 gggcacgggc ttcgtcgccc tgatcaagat gatgatcagc ccgatcatct tctgcacgat
     3601 cgtgctcggc gtcggcgcgg tggccaaggc caaggccgtg ggcaaggtcg gcggcctggc
     3661 actgggctac ttcctggtca tgtcgaccat cgccctggtc atcggcttgg tcgtgggcaa
     3721 cctcctgcat cccggtgacg gcctgcagat caccgaggcg gcgcgcgcca gcggcgagga
     3781 gcaggccgcg cagggcagcg agagcacgat cgagttcgtc ctcggcatca tcccgacgac
     3841 gctcgtctcg gcgttcaccg agggtgaagt cctgcagacg ctgctggtgg cgctgctggt
     3901 cggcttcggg ctgcagacca tgggccccaa ggccgagccg gtgctgcgcg gcgtcgggca
     3961 cctgcagagg cttgtgttcc gggtgctggc gatgatcatg tgggtggcgc cggtcggcgc
     4021 gttcggcgcg atcgccgccg tggtcggcga gaccggcgtg gcggcgctgc gcagcctcgc
     4081 ggtgatcatg ctcggcttct acgcgacctg cgtggtgttc gtggtcgcgg tgctggggct
     4141 gctgctgtgg gcggtggcgc gggtcaacct gttcgccctg ctgcgctacc tgagccggga
     4201 gttcctgctg atcctgtcga cctcgtcctc cgaggtcgcg ctgccccggc tcatcgccaa
     4261 gatggagcac ttgggggtga gccggaccgt cgtcggcatc accgtcccga ccggatactc
     4321 gttcaacctc gacggcaccg cgatctacct gacgatggcg acgctgttcg tggcgaacgc
     4381 gaccggcgcc ccgctctccc tgggcgagca ggtctcgctg ctgctgttca tggtcatcgc
     4441 cgcgaagggc gccgccgggg tcaccggcgc gggcctggcc accctggcgg gcggcctgca
     4501 gtcgcaccgg cccgacctgg tcgacggcgt cgggctgatc gtgggcatcg accggttcat
     4561 gtccgaggcg cgggcgctga ccaacttcgc gggcaacgcg gtggccaccg tgctcatcgg
     4621 cacctggacc aagcagttcg accgcggccg ggcgggcttg gtgctcaccg gccaagcccc
     4681 gttcgacgag gccaccctga ccgacgacca ctcgcccagc cagaacaccg ccccggtccc
     4741 cggacctgtc gccatccccc ggcagcgcag gctgcacggg cagccgatct cggaagacca
     4801 gcaaccgaag acgtgacccc ctatgccgac ggccgtgatg gtcgttgaac cggctgaacc
     4861 gcccttccga tgcccccggt cgggcggttc agtcggttat tgggggcctt ccggttccag
     4921 ctagttgtcc tgtgctgtcg ccttgccgtg ttcgacctgc gcggtgacgg tggcctggac
     4981 tgcgagtgaa cgtcttttga tcaccagacc ggatggatca gggcccgggt gcggacgccg
     5041 cggcggcgca gccgggcgac cagcgcgcgg tcgttgccgt ggccgtagct gagcggctgc
     5101 aggtccgggc tcaccgcacg gaccacccgc aacgggccgg tcgccacgtc cgcgctggtc
     5161 acgtcgacca cggccacccg gaccccggcc gcgccgaggg tgcccgccag gtcggtcagg
     5221 gaggtgtcca gggcgggctc gcgcaggtcg cgcaaccgcg aggtgccccc gcagcgcagc
     5281 cggtcgaacg cgtcgacgcg ctcgaccggg aagtagtagg cggcgtggtc gagcatctcc
     5341 cgcacgccct ggggccgcgc ggggaccggg tgcgcgcgct cgcgcagcag ggccgccagg
     5401 tgcggggcgg tctgggcgag ttcgagcacg gcggcgcgga tggccgcgcg cggcgagcgg
     5461 tcggcgccga ggccgagggc gacgccgggc cagcgcctgc cgtcgccgat ggcgagcgcg
     5521 acggcggtgg cgccgtaggt ggaggtgggc agcaggtaca cctccaccga gggcccttgg
     5581 gcttgcagcg cctcgatcac cgcgtggacg tcgtcgtcca gggtctcgtc caactccacg
     5641 aaccggccgc gctccccggt gagccacgcg gccatcatcg cgtcgcgctc gaccagttcg
     5701 agggtggccc gcacggcggc ggtgtcgatg tcggcgcccg cggcgagacc gttggaggtg
     5761 ccctggcaga tcacgtgctc ggggagcacg gtcatggcga ggtaggcgaa cacggcgggc
     5821 acccagaccg gggtgtcggt cccgagccag gcgccccgca cccatgggtg gtccacccgc
     5881 cggtcgaacg gcacgcacgg gaatcccgcg gcggcgtact gctccggctc atagagggcg
     5941 aactcgcgcg ggtccaggat ctcgccgtcg aggtctgcgg gccgggccca cgccaaccgg
     6001 tccgaatcag gcagcgacgc cgagtaccgc tcgatcgcct ctcccaccgc cgacctgatc
     6061 gccgcgctcc gggtcatccc cttgccccac ccgatcggca gcgcccgcgg caccccgtcg
     6121 gcgtcgagca ggtgcggcga cgccgcggtg gcggtgtgcg ggccggactc ccccaggggc
     6181 tgccgtagct cgatccaggg gacgacaccg gtcaccgggt cgacccagcc cgcgagcgcc
     6241 gccagcagcg ccgccgggtc gtcgtcttct ccttcctctg gcaacgccac cgcgctgtca
     6301 ccggtggcgc caccgcacac atcgcaggcg ggcaacggga tcacccggtg ccacaccggc
     6361 tccgccccac ccacctcggc gacgtggccg atgaggtcgc gggcgtccgc gcgcaggatg
     6421 tcccgcacca ggccgacaat ctggtcaagc gcccgcccag ccgcgccgcc ccgctccgcc
     6481 cccgcggtgt ccagcaccgg cgagctttcc gccgaggatt cccgcgcctg cgcacccgct
     6541 gagccccgca tgtcctccgg gcccgagtgg ggcatccgcg cactggcgcc cgaagcagcg
     6601 gcggcgggtt tgcccgcgcc cccggcaact gccgcgtcga cccgggttgt gtcctcggcg
     6661 tcgtccggcg gccgagccgg gttccgggcg ttttccggtg ccaccgaagc cgcttgccga
     6721 gcaccggacg cggggtccgc gccccctggg gccagtcgca ttgtgtcgtc agcgaccgtc
     6781 acaggcgcct tggctggtga aacacctgcc gcgatcaccg gggccagccg acgggtgtcc
     6841 tcggcgctcg ggtcgctggc ccgcgcgggc gcgatcgccg gtttcaggac gcccggggcg
     6901 gccgtcaccc ccgttccgga cgagcagacg ggcgaggtcg ccttgcgggc cgcggcggcg
     6961 actctgcggg cgcgggcgca ttccgcgcag cccggttcgc cgggaatggc aaggggtccg
     7021 acgaggacgg tgtcaggggc ggtgtcaggg gcggtgtcat cgcctgggac gacggtcagg
     7081 gcgcgcaggt tggcggtgcg ggcccagcgg gcgaactccc ggctctcccc caccgccacc
     7141 gccagccgga cgatcggcgc gagcggacga ccggggcttg cgaagactgc cacctcgtcc
     7201 ccgaactcct gccggagccg gtcgcggacg agggcggccg tctccaggca ggccggctcg
     7261 gccgcgcgga ccggcgtcga atcaaacccc acgtgccgag ccgatcttct cggcggtccg
     7321 ctcgaccggc ctgcccccgg cccacacctg gttcacccgg ccccgcatgg cgtcgacacc
     7381 gtgcccactg agccgcgccg ggagggcacg gcgcggcggt ggcacccggg cgtcgagtcg
     7441 cctggggtcg ggcatgtcgt cgtcctcctc gtccctgtgc gcgccggacc gcgcctacga
     7501 ggtaggagcg agtttcgggg gccgggatac accctgtcca gaggcgttcg ccctggttac
     7561 atcacgtgcg ccaagaactc cccggtgtag ctgccctcgg acttcaccac gtcctccgga
     7621 gtgccctcgg cgaccaccat gccgcccccg gaaccgcctt ctgggcccat gtcgatgatc
     7681 cagtccgcgg tcttgatcac gtcgaggttg tgctcgatga cgatgaccgt gttgcccttg
     7741 tcgaccaggc cgttgatgac gcccaggagt ttgcggatgt cctcgaagtg caggccggtg
     7801 gtcggctcgt cgaggatgta gaccgtgcgg ccggtcgagc gcttctgcaa ctcgctcgcg
     7861 agcttgaccc gctgggcctc gccgccggac agggtgggcg cgggctgtcc gagccggacg
     7921 tagccgaggc cgacgtcgac cagcgtcttg aggtgccggt ggatcgcctt gatcggctcg
     7981 aagaactcgg ccgcctcctc gatgggcatg tccaggacct cggcgatggt cttgcccttg
     8041 tagtgcacct ccagggtctc ccggttgtac cgggcgccct tgcagacctc gcacgggacg
     8101 tagacgtccg gcaggaagtt catctcgatc ttgatggtgc cgtcgcccgc gcacgcctcg
     8161 cagcggccgc ctttgacgtt gaacgagaac cggcccggca ggtagccgcg caccttcgcc
     8221 tcggtggtcg acgcgaacag tttgcgcatg tggtcgaaca cgccggtgta ggtggccgcg
     8281 ttggaccggg gggtgcggcc gatcggcgac tggtcgacct ggacgagctt gtcgacgtgt
     8341 tccaggccct tgacccgggt gtgcctgccc gggacctgcc gggcgccgtt gagcttgttc
     8401 gccaggacgg tggccaggat gtcgttgacg agggtggact tgcccgaccc ggacaccccg
     8461 gtcaccgcga ccagcgcgcc gagcgggaac gccacgtcga tgccgcgcag gttgtgctcc
     8521 cgcgcgccga ccacggtgag ctgccgcttc ttgtcgatgc cccggcggac ggcgggcatc
     8581 gggatctcgc tgcggcccgc gaggtaggcg ccggtcagcg agtccttgtt cttgagcagt
     8641 tccttgaacg tgccgctgtg cacgaccttg ccgccgtgct cgcccgcgcc cggcccgatg
     8701 tcgaccaccc agtcggaggc gcggatcgtg tcctcgtcgt gctcgaccac gatcagcgtg
     8761 ttgcccaggt tgcgcagccg ggtcagcgtc tcgatgagcc ggtggttgtc gcgctggtgc
     8821 aggccgatcg acggctcgtc cagcacgtag agcacgccga cgaggccgga gccgatctgg
     8881 gtggccagcc ggatccgctg cgcctcgccg ccggacaggg tggcggacgc gcggtcgagc
     8941 gagaggtagt ccaggcccac gtcgagcagg aaccgcaggc gcgcctggat ctccttgagc
     9001 accgcgcccg cgatcatcgc ctcgcgcttg cccagggtca ggccgtcgag gaacgccgag
     9061 cactccccga tcgacatggc cgacacctcg gcgatcgact tgtcgccgtg ctcggcgtgc
     9121 tcgagggtca ccgcgaggat ctccggcttg agcctgctgc cccggcacgc ggggcacggg
     9181 acctcccgca tgtagccctc gtacttctcg cgcatgtact cggagtcggt ctgctcttgg
     9241 cgccgctcca ggaacgggat gacgccctcg taggccgcgt agtacgaccg ctcgcgtccg
     9301 tagcggttct tgtagcggac gtgcacctgc tcgttgacgc cgtgcagcac cgccttctgc
     9361 gccttggcgg gcagcctgcg ccacggggtg tccatccgga atccgagagc ctcggacagc
     9421 gaggtgagca gccggacgaa gtactcggcg gtctgcccgc ccgcccacgg cgcgatcgcc
     9481 ccgtcggcga gggaaagctc gtcgtccggg acgaccagtt ccgggtcgac ctccttcttc
     9541 acgccgatgc cggtgcactc ggggcacgcg ccgtagggcg agttgaagga gaacgagcgc
     9601 ggctccaggt cttccaggcc gagggcgtgc cccttggggc aggccaggtt ctcggagaag
     9661 ccgcgcaccc ggtgcgggtc gttctccggc aggtccacga aatccaactc caccaggccg
     9721 tcggccaggc gcagcgcggt ctccaccgag tcggtgaggc gctgcttgga gcttgccttc
     9781 acggcaagcc ggtccacgat caccgcgatg tggtgcttct cctgcttctt gagcttcggc
     9841 gggtcggcca gcgaataggc ggtgccgtcg acgagggcgc gcgagtagcc ctgggtctgc
     9901 aggctcgcga acaggtcgac gtactcgccc ttgcggccgc ggatgaccgg cgcgaggacc
     9961 tggaagcgca cgccgttctc catggcgagc acctggtcga caatctgctg cggggtctgc
    10021 ttgctgatcg gctcgccgca ggtggggcag tgcggcttgc ccgcgcgcgc gtaaagcagg
    10081 cgcaggtagt cgtagacctc ggtgatcgtg ccgacggtcg agcgcgggtt gcggctggtc
    10141 gacttctggt cgatcgagac cgcgggcgag aggccctcga tgaagtcgac gtcgggcttg
    10201 tccatctggc cgaggaactg cctggcgtag gccgacagcg actccacgta gcggcgctgg
    10261 ccctcggcga agatcgtgtc gaacgcgagg ctggacttgc ccgacccgga caagccggtg
    10321 aacacgatca ggctgtccct gggcaggtcg atgtcgaccc cgcgcaggtt gtgctcccgg
    10381 gcgccgcgaa cgacgaggcg gtcggccact gaagtccctt cggtagtgct ctcttgtgaa
    10441 gtgctacggc tgaggtcgca ccgcgacgag gctgtgcggg tactgcggtg cggcggtact
    10501 gctcggtggt gccgcgttct gggcggtgct gcgtttttgg gtagtgccgc tttaattggt
    10561 gctgcttttg ggtggtgctg cttttggtgg tgccgcactg ctgggtggtg ctgtggtgat
    10621 gctggtgggt cgtgctggcc tgccgggcgt cgcgtcagcc gagcagggcg cgacagcggg
    10681 gtgccgggtt gcttggctgg gtgagcggcc acggcgatgg caccgctcat gctaggacgg
    10741 gccaccgaca attctcgacg ggccgggaac ggctatgcac ccgcgaagcg gtacccgcca
    10801 gtaaccagag aagcctacgc tggggacgga gcacatcgct gccgttcact tcccacgagg
    10861 ccgggggtca gcatgagtgg ttcgggcacg gccgccaacg cgtcggtagg ccagccgact
    10921 ctgcctggtc agcgccgctc cagcggcgcg gcgcgggccg cgacgggaca ccaggcggtg
    10981 cgtgaggcgt gggtcgtgct gcgccagcgg gtcgccggtc tcggcgacga cgacttcgcc
    11041 gggccgagca agctgcccgg ctggacgcgc gggcacgtgg tgagccacct cgcgcgcaac
    11101 gccgacgcgc tcgtcaacct cctgacctgg gcgcggaccg ggatcgagca cgcggcgtac
    11161 gccagtcgcg ccgaccggga cgccgacatc gaggcgggcg cggaccgtct tccgcaggtg
    11221 atccgagagg atctttacgc ggcctgtgac cgttttcaca ctgcgatcac acgtctgggc
    11281 gactcggact gggacaacaa gatcatgcat ccgtccggcc gctggttccc cgcggccgag
    11341 gtgcccgagc tggcgctgtt cgaggcgtgg aaccacatgg tcgacctgga cgcgggcgtc
    11401 accttcgacg acgtgccggt cgcgcacctc gaccggctac tcgacctggc cgtgcggccg
    11461 caccgggcac gcacggacgg cgagtcgctg cgcctggccg ccaacttgcc cgacgggcgt
    11521 cagcggacct gggaactggc gatcgccacg ccctcgagtt cgcgggagct gagcgggtcg
    11581 tccacggcgg tcctgggctg gctgaccggc cggggcgacg gcacggactt ggtgggcacg
    11641 ccgccggagc tagccgcctg gggctgagcg ggcacctgcg gcaactcgcg gatcgcctcc
    11701 cgggtcgcgg cgagcgtggc cagcacgcgc cgcaacacga caggcccgga ctcggtgagc
    11761 cagcggtgcg cgggccgctc caccagcccg gtcatcgccc agccgagcag cacggccatc
    11821 gcgacgcaca ggacgagcct gcccgaggcc ccgacgcccg cgtcgagcag gaaccgggcg
    11881 agcacgaaac cgagttcctg gtggaccagg tagaccccga acgagatccc gcccagccac
    11941 cggatcggcc gggccagcga gcgcaggccg gggaggttcc aatccggccc gcccgccgcg
    12001 gccacgatgc ctgccaggat caccccgaac gcgatggtcg acggagtgtc cacaaagtac
    12061 gaatgcgcgt cctgggcgac cagcgcggcg acgagatagg ccgccaggtg cttgccggac
    12121 aggcgtttgc tggtccacag ccagatcgcc acgcccactc cgaacagcgc gacacggtgc
    12181 agggcgagcc cgtcgaacac cgatttcacc cattgctgcg cgtcgtcctg gcgccagagg
    12241 aaccggatca ccagcggcgt cagcagcaac gtccacagca gaaccggaat cc
//
