LOCUS       NZ_FMZK01000012        22122 bp    DNA     linear   CON 26-APR-2024
DEFINITION  Streptomyces prasinopilosus strain CGMCC 4.3504, whole genome
            shotgun sequence.
ACCESSION   NZ_FMZK01000012
VERSION     NZ_FMZK01000012.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces prasinopilosus
  ORGANISM  Streptomyces prasinopilosus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Varghese,N. and Submissions,S.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-OCT-2016) DOE - JOINT GENOME INSTITUTE, LBNL, 2800
            Mitchell Drive, Walnut Creek, CA 94598, 94598, USA
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_900101585.1-RS_2024_04_26
            Annotation Date                   :: 04/26/2024 02:19:25
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,269
            CDSs (total)                      :: 6,190
            Genes (coding)                    :: 5,988
            CDSs (with protein)               :: 5,988
            Genes (RNA)                       :: 79
            rRNAs                             :: 5, 2, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 5 (5S)
            partial rRNAs                     :: 2, 5 (16S, 23S)
            tRNAs                             :: 64
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 202
            CDSs (without protein)            :: 202
            Pseudo Genes (ambiguous residues) :: 0 of 202
            Pseudo Genes (frameshifted)       :: 63 of 202
            Pseudo Genes (incomplete)         :: 175 of 202
            Pseudo Genes (internal stop)      :: 8 of 202
            Pseudo Genes (multiple problems)  :: 40 of 202
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 12:44:39
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 111882
            Orig. end                         :: 134004
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            FMZK01000012.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22122
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="redox-cofactor"
                     /region_number="2"
                     /rules="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /tool="antismash"
     cand_cluster    1..22122
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(cds(PF04055 and (TIGR04085 or SPASM))
                     and (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /kind="single"
                     /product="redox-cofactor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22122
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12122](-)"
                     /cutoff="20000"
                     /detection_rule="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /neighbourhood="10000"
                     /product="redox-cofactor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12122)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /neighbourhood="10000"
                     /product="redox-cofactor"
                     /protocluster_number="1"
     gene            complement(1152..2363)
                     /locus_tag="BLS36_RS25035"
                     /old_locus_tag="SAMN05216505_112114"
     CDS             complement(1152..2363)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018844301.1"
                     /locus_tag="BLS36_RS25035"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216505_112114"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_240503245.1"
                     /transl_table=11
                     /translation="MTRDNSGPHLCIAGRPAAARLRAVAPALTRRIVARLRAELPAYAE
                     LPGEALTGDIADIVQHNLRMLADSLELRRPPGDTELARQRDSAGQRAEEGVPLDAILTA
                     YHLGTTMCWQELSAGARPGELPDVTQTVTHILTLQQYVTSAVSAGYLEARRALDSEEHR
                     GRHALMTALLAGDPAEGGSERYVALTLALAPHPDETGEGPGARIAARRKLRRIRSALDA
                     HGGEPPLTALGPDGGTVLLPAAAPPPWTELTALVARTADAAGVPVTAAAETAEPPGIPA
                     AVARTAEVVALVRRSGRPPGLYRLADVLLDYQLSRPGEALYGLASLLRPLEGKPELLRT
                     LETHLARELDRRATAAALHIHPNTVDYRLRRITTLTGLSPSRPLDLQHLGAALVARRSL
                     CPDG"
     misc_feature    2384..2401
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 14.55"
                     /tool="antismash"
     misc_feature    2602..2617
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: medium, score: 21.43"
                     /tool="antismash"
     gene            2649..3476
                     /locus_tag="BLS36_RS25040"
                     /old_locus_tag="SAMN05216505_112115"
     CDS             2649..3476
                     /EC_number="3.1.-.-"
                     /GO_function="GO:0016788 - hydrolase activity, acting on
                     ester bonds [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018382613.1"
                     /locus_tag="BLS36_RS25040"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216505_112115"
                     /product="SGNH/GDSL hydrolase family protein"
                     /protein_id="WP_244904940.1"
                     /transl_table=11
                     /translation="MLAGAPAATAAESAKGEVYVALGDSMASGPLIPWPTGPLACGRST
                     QNYPHELAERLDVAEFRDVTCSGAKTDHMTQPQKLSLLDQDMGEAPPQFDALSADTTLV
                     TLTIGGNDAGLVGIAQDCMQLDPTAEPCKTGYTEGGVDRVAQRVDSAAPKVAAVLDGIR
                     AKAPDARVIVAGYGLYVKKGGCWPVQPVLGVDADYLQGAVDRLNGILAEQAAAHDAEYV
                     DLRTPSAGHDACQAPSRRWIEGYVPTSPAAPLHPNAAGEAAYARLIGDHITGS"
     gene            <3638..4633
                     /locus_tag="BLS36_RS25045"
                     /old_locus_tag="SAMN05216505_112116"
                     /pseudo=""
     CDS             <3638..4633
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018533215.1"
                     /locus_tag="BLS36_RS25045"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216505_112116"
                     /product="hypothetical protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="IPRTAFTGRTPSRPALYGHGLLGSRNEVGAGNVKAMAGEHNFTFC
                     ATDWIGMAADDVPVVLGALADMNGFPAIPERSQQSMLNAPFLGRAMIHRDGLPADPAFR
                     APGGRPLLDTRHGLVYDGNSQDGILGGALLAASTDIERGVLGVIGMHYGLLLDRSSDFA
                     PFQRVLDAGYPDKLRQQVVLQLYQMVWDRDETNGYASRPAGDHDVLMHIAHGDHQVAMV
                     AADVQARTLGARLHAPALAPGRSPDRVPHWGIRTAGTPFRGGSAMVVRDSGTPTPPLTN
                     TPPRAPEYGQDPHSDPRNMPTARQQKATFLTTGWVMDACGGAPCTTLPTP"
     gene            4647..5786
                     /locus_tag="BLS36_RS25050"
                     /old_locus_tag="SAMN05216505_112117"
     CDS             4647..5786
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018894732.1"
                     /locus_tag="BLS36_RS25050"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216505_112117"
                     /product="alkaline phosphatase PhoX"
                     /protein_id="WP_055575010.1"
                     /transl_table=11
                     /translation="MQRRSFLRTVTAGTGAAVFCGTLWQQAGHAAPAGAASGSPYGPLL
                     APDANGVALPAGFTSRVVARSLRPVGGTIWHSAPDGGACYADGDGWIYVSNSEIPLLGG
                     ASAIRFRADGSVDRAYRILSGTHLNCAGGATPWNTWLSCEETFRGRVFETDPYGRKEAV
                     AHHAMGRFKHEAAACDPDHRVVYLTEDEDDGCFYRFTPDTWGDLSSGRLDVACTTSGDG
                     VEWREVPNPSAPLVQTRRQLAAARHFDGGEGCHYAEGICYFTAKGDRQVWAYDTRDSTI
                     TSVYNSDGTLTGVDNITGTAAGDLYVAEDGGNMEINIITRDGVVAPILRVDGHPDSEIT
                     GPAFSPDGSRLYFSSQRGTSGEISGSGGVTYEVRGPFRH"
     gene            complement(5850..6023)
                     /locus_tag="BLS36_RS33530"
     CDS             complement(5850..6023)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="BLS36_RS33530"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_175400422.1"
                     /transl_table=11
                     /translation="MGDVVAVAEGAHHVLVPLRGLLTAVFPRFPPAVKTTREEVTAWPA
                     PAVHRCLHAEHS"
     gene            <6003..6376
                     /locus_tag="BLS36_RS32000"
                     /old_locus_tag="SAMN05216505_112118"
                     /pseudo=""
     CDS             <6003..6376
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011026834.1"
                     /locus_tag="BLS36_RS32000"
                     /note="frameshifted; incomplete; partial in the middle of a
                     contig; missing N-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /old_locus_tag="SAMN05216505_112118"
                     /product="transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="DRNDVTQLPPLLDKIPTVAGVAGRPRHRPDCSSLTAATTTPSTGA
                     CHASAGSGR"
     gene            complement(6365..7216)
                     /locus_tag="BLS36_RS25060"
                     /old_locus_tag="SAMN05216505_112119"
     CDS             complement(6365..7216)
                     /GO_function="GO:0016407 - acetyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016823088.1"
                     /locus_tag="BLS36_RS25060"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216505_112119"
                     /product="arylamine N-acetyltransferase"
                     /protein_id="WP_074995277.1"
                     /transl_table=11
                     /translation="MPETVPTTSFDLDAYLKRIGWEGERRADLATLRGVHMAHALTVPF
                     ENLDPVRGVVPSLDPADLTVKLVHGRRGGYCYEHNTLFAGVLEALGFRVTLLAARVVVG
                     TDRFESRPRTHMALLVEVPGERRPHLADVGFGSVGALLEPVPLVVGTEFHDAGRRHRLV
                     HVPHDGPLEMWVLEAYGMTGTGRADGWEAQYAFTMEPFEQPDFEVVNWHIATNPRSPFS
                     RRPYIQRLTSGRHLFLDGRHLTETRADGAVTARELTNEREARRLLDEEFGIDVPDGVRL
                     LG"
     gene            7404..7526
                     /locus_tag="BLS36_RS34580"
                     /old_locus_tag="SAMN05216505_112120"
     CDS             7404..7526
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="BLS36_RS34580"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="SAMN05216505_112120"
                     /product="hypothetical protein"
                     /protein_id="WP_280519591.1"
                     /transl_table=11
                     /translation="MIVTQDVRPDVWTVELEEALVRIGHQFGRVDLRRRYSHSW"
     gene            complement(<7768..>8148)
                     /locus_tag="BLS36_RS25065"
                     /old_locus_tag="SAMN05216505_112121"
                     /pseudo=""
     CDS             complement(<7768..8148)
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020133533.1"
                     /locus_tag="BLS36_RS25065"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus and C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /old_locus_tag="SAMN05216505_112121"
                     /product="IS6 family transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MGDTWRLDEVFIKINGELKYLWRAVDADGTVLDILVQNRRDTAAA
                     RRFFRTLLKRTCSVPRVVVTDKLRSYGTAHRELMSSVEHRSHKGLNNRAENSHQPTRQR
                     ERAMKGFRSIGGAQWFLSAFSSI"
     misc_feature    complement(8105..8118)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 19.7"
                     /tool="antismash"
     gene            complement(8210..9712)
                     /locus_tag="BLS36_RS25070"
                     /old_locus_tag="SAMN05216505_112122"
     CDS             complement(8210..9712)
                     /EC_number="1.1.5.-"
                     /GO_function="GO:0016901 - oxidoreductase activity, acting
                     on the CH-OH group of donors, quinone or similar compound
                     as acceptor [Evidence IEA]"
                     /GO_function="GO:0070968 - pyrroloquinoline quinone binding
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:TIGR03606.1"
                     /locus_tag="BLS36_RS25070"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216505_112122"
                     /product="glucose/sorbosone family PQQ-dependent
                     dehydrogenase"
                     /protein_id="WP_074995278.1"
                     /transl_table=11
                     /translation="MHRILRGPATTALVLALGVSLTGAAITGGDPSGNSDPDAVSPPAD
                     TSTPPASGTFVKRVVTTGLNNPYEVVRAPDGSLWATEKTGKKVTRIDTKSGAKTTLLSL
                     PQAVHTEGGQDGVLGLAIGERSGTGEVYAYISYSYDVDPGPVVQARTKIERYTYDSGRK
                     RLHSPKTVISGMPSGYDHQSARLRLGPDGKLYYTIGDQGANQFGNYCRPIYAQRLPTAG
                     EVQGRDWVAYRGKTLRLNTDGSIPEDNPVLAGVRSHVYTYGHRNAQGLAFGPDGTLYQN
                     EMGPKTDDEINVLRSGGNYGWPNVSGYQDDKAYVYGNWSASWPTPCEELTFSNFEIPET
                     VPVRKESDFTKPFVEPIRTFGTVESDFDFEDPACRPSGEAAVCWPTIAPSGFEHYGTSR
                     KAAGATGEGIPGWENSLVMTTLKDGTLYRVDLTDDGRRVSKVTRLLTEQNRFRDTEFSA
                     DGKSVFAITDSAGSIRELGADRAPAPDGLENPGAVIEYRLQD"
     gene            complement(10001..11122)
                     /gene="pqqE"
                     /locus_tag="BLS36_RS25075"
                     /old_locus_tag="SAMN05216505_112123"
     CDS             complement(10001..11122)
                     /GO_process="GO:0018149 - peptide cross-linking [Evidence
                     IEA]"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: SPASM"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: TIGR04085"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: PF04055"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010357439.1"
                     /locus_tag="BLS36_RS25075"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216505_112123"
                     /product="pyrroloquinoline quinone biosynthesis protein
                     PqqE"
                     /protein_id="WP_055572425.1"
                     /sec_met_domain="PF04055 (E-value: 1.4e-25, bitscore: 84.5,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="SPASM (E-value: 3.7e-08, bitscore: 27.7,
                     seeds: 166, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 7.2e-11, bitscore:
                     36.3, seeds: 281, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSVPASPWALLAELTHACPLHCPYCSNPVDLTRRSRELGTAHWAE
                     VMRQAGELGVVHTHLSGGEPLLRSDLEQITTAAETAGIYTQLVTSGVGLDADRLAALAD
                     AGLRSVQLSVQAADPRANDRIAGRPSSFTAKEKAAALVRDAGLPLGLNVVLHRENLDAI
                     DAVIDLGVVWDVDRIELANTQFYGWGLLNRTALLPTPGQLARARDTVARRRAGLPGRPE
                     LVWVVPDHFDGVAKPCMGGWGAVSLTVAPDGTVLPCPAAASLPDLDPPNVLDHPLDWIW
                     HRSPAFNRYRGTDWMTEPCRSCDMRTRDFGGCRCQAYALTGDATHTDPACRLSPDHALV
                     RSLVEHSEEGAPPKPWVYRRAGRRARRCPGPTG"
     gene            complement(11119..11394)
                     /gene="pqqD"
                     /locus_tag="BLS36_RS25080"
                     /old_locus_tag="SAMN05216505_112124"
     CDS             complement(11119..11394)
                     /GO_function="GO:0048038 - quinone binding [Evidence IEA]"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqD"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: PqqD_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009712684.1"
                     /locus_tag="BLS36_RS25080"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216505_112124"
                     /product="pyrroloquinoline quinone biosynthesis peptide
                     chaperone PqqD"
                     /protein_id="WP_055572426.1"
                     /sec_met_domain="PqqD_RRE (E-value: 2.6e-16, bitscore:
                     53.1, seeds: 9, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 1.2e-08, bitscore: 29.1,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTQPAAADWRPALVPAAVLRHDPVRGADLLLLPERVVVLRGRGE
                     VVVGLCDGTRTVRAIVEELTARFPGAPVADEVPAFLDGLRREGCLR"
     aSDomain        complement(11125..11370)
                     /aSDomain="PqqD_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing protein in a pyrroloquinoline
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_BLS36_RS25080_PqqD_RRE.1"
                     /evalue="3.10E-17"
                     /identifier="RREFam006.1"
                     /label="BLS36_RS25080"
                     /locus_tag="BLS36_RS25080"
                     /protein_end="90"
                     /protein_start="8"
                     /score="53.1"
                     /tool="antismash"
                     /translation="DWRPALVPAAVLRHDPVRGADLLLLPERVVVLRGRGEVVVGLCDG
                     TRTVRAIVEELTARFPGAPVADEVPAFLDGLRREGCL"
     gene            complement(11391..12122)
                     /gene="pqqC"
                     /locus_tag="BLS36_RS25085"
                     /old_locus_tag="SAMN05216505_112125"
     CDS             complement(11391..12122)
                     /EC_number="1.3.3.11"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: TIGR02111"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019524875.1"
                     /locus_tag="BLS36_RS25085"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216505_112125"
                     /product="pyrroloquinoline-quinone synthase PqqC"
                     /protein_id="WP_055572427.1"
                     /sec_met_domain="TIGR02111 (E-value: 3.9e-84, bitscore:
                     275.6, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTGTTPLTEHTDPWSPADLEGRLRDVARDHYHDRHPFNIRMHNG
                     DLRPGELRRWITNRFHYQRHIPVKDALILAQLDSPPLRRMWMRRIEDHDGRQEGQGGIE
                     RWLRLGEAAGLDRGTLLDGQGVLPGVRLAVEGYVNFCRLRTPLEGVAASLTELAAPDIM
                     RTRIDAFERHYRWIEPDGLAYFRSRVRQGRRDSSEALGLVLEWARTPAEQERAVAALVF
                     KCDVLWALLDAVSTAGERERG"
     gene            complement(12119..13027)
                     /gene="pqqB"
                     /locus_tag="BLS36_RS25090"
                     /old_locus_tag="SAMN05216505_112126"
     CDS             complement(12119..13027)
                     /codon_start=1
                     /gene="pqqB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014669247.1"
                     /locus_tag="BLS36_RS25090"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216505_112126"
                     /product="pyrroloquinoline quinone biosynthesis protein
                     PqqB"
                     /protein_id="WP_055572428.1"
                     /transl_table=11
                     /translation="MLLQVLGTAAGGGIPQWNCACPGCSGARAHPRRRRRHASLAVRAG
                     EGRWYLVNATPDLGEQIEAHPALHPGPGRRQTPVAGLVLTDAELDHTTGLTRLREAHDG
                     LEVFATGPVRRAVRDRLCLDAVLAPYTEVAWRDLPVRGSVPLGAADDDEGLRISALPVS
                     GKRPRYAAEEPDDEAWVVALRLYDPATGASVLYAPALAAWPDHLHRAAAEADCVLVDGT
                     FWDDEEPRRAGIRDRTATGMGHLPINGPGGTAALLAPLTARCLYTHLNNTNPLVDPDAP
                     QHKKLARLGLEVAHDGMVIQP"
     gene            complement(13037..13168)
                     /gene="pqqA"
                     /locus_tag="BLS36_RS25095"
                     /old_locus_tag="SAMN05216505_112127"
     CDS             complement(13037..13168)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014669248.1"
                     /locus_tag="BLS36_RS25095"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216505_112127"
                     /product="pyrroloquinoline quinone precursor peptide PqqA"
                     /protein_id="WP_074995280.1"
                     /transl_table=11
                     /translation="MADHTERLEQTPPRPVEESGWQTPEFVIVETALEVTAYSLATR"
     gene            complement(13452..14858)
                     /locus_tag="BLS36_RS25100"
                     /old_locus_tag="SAMN05216505_112128"
     CDS             complement(13452..14858)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1175: pyridine nucleotide-disulfide oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014669423.1"
                     /locus_tag="BLS36_RS25100"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216505_112128"
                     /product="FAD-dependent oxidoreductase"
                     /protein_id="WP_055572429.1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 1.3e-57, bitscore:
                     189.2, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSEKDVQDVDLLVIGGGKAGKSLAMDRAKAGWKVAMVERDKIGGT
                     CINVACIPTKALVGSARTLLTARHAARMGIEIGSEPAVDLEALRAHKEDVVGGMVEAHK
                     KLFADSGMDFVLGTARFTGERTVEITAADGATRAVRGRDVVINTGTTPALPDLPGIADA
                     QVWDSETILRLERLPETLLVLGGGYVGAEFASMFAVFGTRVTLLQGRDQLLPREDRDVA
                     DEVARVLTGQGVDVRLGARASAVRREEGHGDVVVTLDDDSEVRGQELLVATGRTPVTAG
                     LGLEAAGVRLTDRGFVAVDGHLRTTADHVWAAGDVAGSPQFTHASWHDFRVLRDNLTGG
                     DTVTSGRIVPYTVFTTPELARIGLTETEARAQGHDVKVARLRVAAIPRAKTLHEGTGIW
                     KAVVDAGTDQILGVALLGHHAGEVLSAVQMAMLGRLPYQQVRDAVFTHPTMGEGLNLLF
                     DTLDDDKARG"
     misc_feature    14839..14853
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 18.04"
                     /tool="antismash"
     gene            complement(14912..15238)
                     /locus_tag="BLS36_RS25105"
                     /old_locus_tag="SAMN05216505_112129"
     CDS             complement(14912..15238)
                     /EC_number="2.3.1.-"
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018563160.1"
                     /locus_tag="BLS36_RS25105"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216505_112129"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_055572430.1"
                     /transl_table=11
                     /translation="MSAITRDNPAEHRYEIHDDGRLAGFAVYELTDGNIAFTHTETLPE
                     FGGRGLAGQLVAEALDDARRRNLAVLPYCPYVRKVIARDTGTYLDLVPEKDRARLGFPS
                     AETA"
     gene            complement(15235..15759)
                     /locus_tag="BLS36_RS25110"
                     /old_locus_tag="SAMN05216505_112130"
     CDS             complement(15235..15759)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009187285.1"
                     /locus_tag="BLS36_RS25110"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216505_112130"
                     /product="carboxymuconolactone decarboxylase family
                     protein"
                     /protein_id="WP_055572431.1"
                     /transl_table=11
                     /translation="MSTTPPGDRVWIDRQSPQAYQALRETAKTVRETARAAGLDRTLVE
                     LVNIRVSQINGCASCLHLHVRAALRGGETTQRLAVLPAWRDAGLFTDRERAALALAESV
                     TVLPDARVQDQDYAEATAHLTAEEISAVAWVALTMNAFNRVSIVSRHPVPPQKATAPRP
                     SRAATAQEGPA"
     gene            complement(15756..16709)
                     /locus_tag="BLS36_RS25115"
                     /old_locus_tag="SAMN05216505_112131"
     CDS             complement(15756..16709)
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1208: pirin
                     domain-containing protein"
                     /gene_kind="other"
                     /inference="COORDINATES: protein motif:HMM:NF014708.4"
                     /locus_tag="BLS36_RS25115"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216505_112131"
                     /product="pirin family protein"
                     /protein_id="WP_055572432.1"
                     /transl_table=11
                     /translation="MSGPVSTVDASADQADTGHPEPPCLQVSDSREATVGTIRVRRALP
                     RRGRRTVGAWCFADHMGPADVTENSGLDIGPHPHIGLQTVTWLTDGQVLHRDSLGSEQV
                     IEPGQLNLMTSGRAVSHAEEATGHYRGTLEGIQMWTALPENTRHSQPAFEHHAELPRTD
                     LDGQAGAATVLIGDLGGLASPARHDTPLVGVELDLRAPATVPLRPDWEYALVVLQGAVA
                     VRDKPLHPGRLGYLGEGRDELPLDVHEPARVMLLGGEPFPEPILMWWNFVGRNREEIDA
                     AHASWARQDDRFGRVASSLPLIPTAAPYWQRASGDR"
     gene            complement(16965..17585)
                     /gene="wrbA"
                     /locus_tag="BLS36_RS25120"
                     /old_locus_tag="SAMN05216505_112132"
     CDS             complement(16965..17585)
                     /EC_number="1.6.5.2"
                     /GO_function="GO:0003955 - NAD(P)H dehydrogenase (quinone)
                     activity [Evidence IEA]"
                     /GO_function="GO:0010181 - FMN binding [Evidence IEA]"
                     /codon_start=1
                     /gene="wrbA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004978842.1"
                     /locus_tag="BLS36_RS25120"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216505_112132"
                     /product="NAD(P)H:quinone oxidoreductase"
                     /protein_id="WP_055572449.1"
                     /transl_table=11
                     /translation="MSTQIKLAVVYYSSTGVVAEMAREIAEAAEKTGAEVRLLRAAELA
                     PQAAIESNPAWAANAAATADIPVATPPDIEWADAVIFGSPTRFGNIASQLKQFIDTLGG
                     LWAQGKLADKVYSGFTASSTTHGGQESTLLALYNSVHHFGGILVSPGYTDPAKFADGNP
                     YGTSHVDAQGNNPVGDTTRTAARIQAERVVKIASGLKAGLAAA"
     misc_feature    17746..17759
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 14.0"
                     /tool="antismash"
     gene            17816..18563
                     /locus_tag="BLS36_RS25125"
                     /old_locus_tag="SAMN05216505_112133"
                     /pseudo=""
     CDS             17816..18563
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1208: pirin
                     domain-containing protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016471483.1"
                     /locus_tag="BLS36_RS25125"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216505_112133"
                     /product="pirin family protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MASALDVRRTDERLRTRVGRLGSRRSSSFSRHGNAENTHCGLPLV
                     SGVASVVPGTGFDAHPHRDMEIITWVLDGGPAHQDSEGHNGVIHPGLVQRMSAGTDILH
                     GEKRDSRTLTGKPAHQAPVHFIQVWVLPDEAGIKPGYEQLDIDDELARGGWTTLASGLP
                     RRAIGIRQKHAALHVARVRPGKTLLITTAPFTHLFLARGSRTGGCGSAGLR"
     misc_feature    complement(18957..18973)
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 19.65"
                     /tool="antismash"
     misc_feature    18958..18972
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 16.7"
                     /tool="antismash"
     gene            19477..21654
                     /locus_tag="BLS36_RS25130"
                     /old_locus_tag="SAMN05216505_112135"
     CDS             19477..21654
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010983162.1"
                     /locus_tag="BLS36_RS25130"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216505_112135"
                     /product="discoidin domain-containing protein"
                     /protein_id="WP_055572433.1"
                     /transl_table=11
                     /translation="MHPHPIRNVRYAAVSATVVALTAGMLVALAPAPAHAATGATLPFT
                     SIEAESVPTTGTRIGPDYTQGTLASEASGRRAVRLTAGQRVEFTVPRAANAVNVAYSVP
                     DGQSGILNVYVNGQKLPKTLPVTSKYSYVDTPWIAGAKTHHLYDNARLLLGRDVQAGDR
                     VAVEAADVQVTVDVADFEQTAGPAAKPSGAVSVTDRGADPSGRGDSTQAFREAIAAAQG
                     GVVWIPPGEYRLTSSLSGVQNVTIQGAGHWHSVVRASRFIDQPNSSGRVHIKDFAVIGE
                     VTERVDSSPDNFVNGSLGPNSSVSGMWLQHLKVGLWLTGNNDNLVVENNRILDTTADGL
                     NLNGNARGVRVRNNFLRNQGDDALAMWSLYAPDTNSSFENNTISQPNLANGIAIYGGTD
                     ITVRNNLVADTNALGSGIAISNQKFLDPFHPLAGTITVDGNTLVRTGAMNPNWNHPMGA
                     LRVDSYDSAIEAQVRITNTTITDSPYSAFEFVSGGGRGHAAKNVTVDGAAVRNTGTVVV
                     QAETSGAATFRNVTATGVGAAGIYNCPYPAGSGTFTLTDGGGNSGWSSTWSDCSTWPQP
                     GQGSPDPDPARNLAKGRPATATGSQDVYTPGKAVDGDVNTYWESANHAFPQNLTVDLGS
                     AQGVRRLVLKLPPAQAWQARTQTLSVQGSTDGSAYSTVVMPKDYRFDPATGNTVTVNLP
                     AGTNLRHLRLHVTANTGWPGAQFSEVEAYLS"
     misc_feature    21734..21748
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 18.37"
                     /tool="antismash"
     misc_feature    22089..22103
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 19.3"
                     /tool="antismash"
     misc_feature    complement(22091..22107)
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 17.35"
                     /tool="antismash"
     misc_feature    complement(22091..22107)
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 23.01"
                     /tool="antismash"
ORIGIN
        1 cgcacgacct gctcggtcag tggaacgccc gggaggccga gctcatcgcg accgatccca
       61 accgagtgcc cccgctcgcg ttgccgccgg atcctcaaag ggcaatcctc ggcacgctgg
      121 aaggcgacgc attcgagcgc gctgcacggg aggcggcacg aaccgcgccg ccacgtgaga
      181 acggcggcaa ccaggacatc aagaacctca cccgtggcgc ccggatcttc atgccggtgt
      241 atgtcgaggg tggcaaactg tccgccggtg acctgcactt cagccagggc gacggcgaga
      301 tcaccttctg cggcgcaatc gagatgggcg gctacctcga tctcggcgtc gacctcatca
      361 agggcggcat gcagacctac ggggtgacga cgaaccccgt gttctacccc ggcaacgtcg
      421 agccgcgcta cagcgagttc ctcaccttcg tcggcatctc cgtcgacgaa gacggccgcc
      481 agcactacct cgactcacac atcgcctatc ggcgggcttg cctgaacgcg atcgaatacc
      541 tgaccaagtt cggctactca cctgaacagg cctacctgct cctcggagcc gccccgatcg
      601 aaggccgctt cagcggcgtg gtcgacatcc ccaactcctg cgccacgctc tatctgccca
      661 ccgccatctt cgacttcgac atccgcccgt ccggcgacgg gccgcagcgc gccgatcggg
      721 gaagctgcgc ccgcacaagc tagtgccgtg tccgcgaacg gtctcccggc cgggccccgg
      781 gccgcaggca gcgatcagga ggatcctcta caccgggcat ctggacggta cgggtgtctt
      841 caccgccgcc tacttccacc cggtgcggag ttcgaggcgg agtcgctggc ctccgggccg
      901 tcggacgtca ccgtgcacgg tgtcgaaggc ccggcccggt cgctgccgaa ggcatcggag
      961 cagcacagcg gtgagtcgct cgtcggttcc ccggtgttca ccgcagcccc gaccgccgca
     1021 cccatcgcgg acgacccccc gacccgctcg cggccggctc gcacttcctg gcgacggccc
     1081 accgcccgtc cggggaacgt acgggcgtgt ccgcgccggg agcggcggtg cggacacgcc
     1141 cggccgggga gtcagccgtc cgggcacagt gaccggcgtg cgacgagggc cgcacccagg
     1201 tgctggaggt ccagggggcg ggacggggac aggcccgtga gggtggtgat gcggcgcagc
     1261 cggtagtcga ccgtgttggg gtggatgtgg agcgccgcgg cggtggcgcg gcggtccagt
     1321 tcgcgggcga ggtgggtctc cagggtccgc aggagttccg gtttgccctc caggggccgc
     1381 agcagggagg ccaggccgta cagggcctcg ccggggcggc tcagctggta gtccaggagg
     1441 acgtcggcca gccggtagag gccgggcggc cggccggagc ggcgcacgag ggcgacgacc
     1501 tcggcggtac gggcgacggc cgccggtatc ccgggcggtt cggccgtctc ggccgcggcc
     1561 gtcaccggca cgccggcggc gtccgcggta cgggctacga gcgcggtgag ctccgtccag
     1621 ggcgggggcg cggcggcggg gagcaggacg gtgccgccgt cggggccgag ggcggtcagg
     1681 ggcggctcac cgccgtgggc gtcgagggcc gagcggatcc ggcggagctt gcgccgggcc
     1741 gcgatccggg cgccggggcc ctcgccggtc tcgtcggggt gcggggcgag ggcgagggtc
     1801 agggcgacgt agcgttcgct gccgccctcg gccgggtccc cggcgagcag ggccgtcatc
     1861 agggcgtggc ggccgcggtg ttcttcgctg tccagggccc ggcgggcctc caggtagccg
     1921 gcgctgacgg ccgaggtgac gtactgctgg agcgtcagta tgtgggtcac ggtctgggtc
     1981 acgtcgggga gttcgccggg gcgggcgccg gcggacagct cctgccagca catggtcgtg
     2041 cccaggtggt aggcggtgag gatggcgtcc agcggtacgc cctcctcggc gcgctggccg
     2101 gcggagtccc gctgccgggc gagttcggtg tcgccgggcg ggcgccggag ttccagggaa
     2161 tcggcgagca tccgcaggtt gtgctggacg atgtcggcga tgtcgccggt cagtgcctcg
     2221 ccgggcagct cggcataggc ggggagttcg gcgcgcagcc gggcgacgat acggcgggtc
     2281 agggcgggtg cgacggcgcg gagtcgggcg gcggcgggac ggcccgcgat gcacaggtgc
     2341 ggcccggagt tgtcacgcgt cacaaagacc cccgtcgaag tctgcgttac cgcccagtta
     2401 aagcagggcc ccgaaagact gcaagatgac cggcggcacc ttccgctcca actccgacac
     2461 ccttgcggat ccgcacccac cgtcccggaa gcgtattcgc gccccttctc ctgtaccgcg
     2521 cgtcgcacag cttgtcgcct tgtcgtcttg ccgtcctcgg gacttcggga gccgcagtga
     2581 acaggtcaca ccgcaaggga actgcccgtc tggtcagatg cgcgctcggc gcgggtctgg
     2641 tggccgggct gctggctggc gcgcccgccg ccaccgccgc cgaatccgcg aagggggagg
     2701 tgtacgtggc cctcggcgac tcgatggcgt ccgggccgct gatcccgtgg cccaccgggc
     2761 cgctggcctg cggccggtcc acgcagaact acccgcacga gctggcggag cggctggacg
     2821 tcgccgagtt ccgcgacgtg acgtgcagcg gcgcgaagac ggaccacatg acgcagcctc
     2881 agaaattgtc cctgctggac caggacatgg gcgaggcgcc gccgcagttc gacgcgctga
     2941 gcgcggacac gaccctggtc accctcacca tcggcggcaa cgacgcgggc ctggtcggca
     3001 tcgcccagga ctgcatgcag ctggacccga ccgcggagcc gtgcaagacg ggctacaccg
     3061 agggcggtgt ggaccgggtc gcgcagcgcg tggactccgc cgcgccgaag gtggcggccg
     3121 tactcgacgg catccgcgcg aaggcgccgg acgcccgggt gatcgtggcg ggttacgggc
     3181 tctacgtcaa aaagggcggc tgctggccgg tgcagccggt gctcggcgtg gacgccgact
     3241 atctccaggg ggcggtggac cggctgaacg ggatcctggc cgagcaggcc gcggcccacg
     3301 acgccgagta cgtcgatctg cgcacgccca gcgcgggcca cgacgcctgc caggcgccga
     3361 gccgccgctg gatcgagggc tatgtgccca cctcgcccgc ggcgccgctg caccccaacg
     3421 ctgccggtga ggccgcgtac gcgcggctga tcggtgatca catcacgggc tcctgacgga
     3481 tgccgtaccc gaagggccgg ccgctgcgac ggcaccgggc gcgggtccca cggccggccc
     3541 ggtcggtgcg ggcgccacgc gctctgcggc tcacgccggc cgtgctgccg accggggcgg
     3601 cgggcggtgt cctgacaccg cccgccgcgg catccggatc ccccgcaccg ccttcaccgg
     3661 ccgcacgccc tcccggcccg ccctctacgg ccacgggctg ctcggcagcc gcaacgaggt
     3721 cggcgcgggc aacgtgaagg ccatggccgg cgagcacaac ttcaccttct gcgccaccga
     3781 ctggatcggc atggccgccg acgacgtgcc cgtggtcctg ggcgccctcg ccgacatgaa
     3841 cggcttcccc gccatcccgg agcgctccca gcagtccatg ctcaacgccc ccttcctcgg
     3901 ccgcgccatg atccaccgcg acgggctgcc ggccgatccc gcgttccgcg cgcccggagg
     3961 ccggccgctg ctggacaccc ggcacgggct ggtctacgac ggcaacagcc aggacggcat
     4021 cctcggcggc gccctgctcg ccgcgtccac cgacatcgag cgcggtgtgc tgggcgtgat
     4081 cggcatgcac tacggcctgc tcctcgaccg cagctccgac ttcgcgccgt tccagcgggt
     4141 gctggatgcc ggctacccgg acaagctgcg gcagcaagtg gtgctccagc tctaccagat
     4201 ggtctgggac cgcgacgaga ccaacggata cgcgtcccgg cccgccggcg accacgacgt
     4261 cctgatgcac atcgcccacg gagaccacca ggtggccatg gtcgccgccg acgtccaggc
     4321 ccgcaccctc ggcgcccggc tccatgcccc ggcgctcgca cccggccgca gccccgaccg
     4381 ggtgccgcac tggggcatcc gcaccgccgg cacccccttc cggggcggct ccgcgatggt
     4441 cgtccgggac agcggcacac ccacaccgcc cctgaccaac acaccgccca gggcacccga
     4501 gtacgggcag gacccgcact ccgacccccg gaacatgccg accgcgcgtc agcagaaggc
     4561 caccttcctg accaccgggt gggtcatgga tgcctgcggc ggcgctccct gcaccaccct
     4621 ccccacccca tgacggaaga ggtcccatgc agcgacgttc cttcctccgc acggtcaccg
     4681 ccggcaccgg tgccgccgtc ttctgcggca ccctgtggca acaggccggc cacgccgcac
     4741 cggccggcgc ggcctcgggc agcccgtacg ggccgctcct cgctccggat gccaacggtg
     4801 tggccctgcc cgccgggttc accagccgcg tcgtcgcccg ctcgctgcgg cccgtcggcg
     4861 gcaccatctg gcactcggcg cccgacggcg gcgcctgcta tgccgacggc gacggctgga
     4921 tctacgtctc caactccgag ataccgctcc tgggcggtgc ctccgccatc cgcttccgcg
     4981 ccgacggctc cgtggaccgc gcctaccgca tcctgtcggg cacccacctc aactgcgcgg
     5041 gcggcgcgac tccctggaac acgtggctgt cctgcgagga gaccttccgg ggccgggtct
     5101 tcgagaccga cccgtacggg cggaaggagg ccgtcgcgca ccacgccatg ggccgcttca
     5161 agcacgaggc cgccgcctgc gaccccgacc accgggtcgt ctacctcacc gaggacgagg
     5221 acgacggctg cttctaccgc ttcacgcccg acacctgggg tgacctgtcc tccggccgcc
     5281 tcgacgtggc gtgcaccacc tcgggcgacg gcgtcgagtg gcgcgaggtg ccgaacccgt
     5341 ccgcgccgct ggtccagacc cgcaggcagc tcgccgccgc ccgccacttc gacggcggcg
     5401 agggctgcca ctacgccgag ggcatctgct acttcaccgc caagggcgac cgccaggtct
     5461 gggcgtacga cacccgggac tcgacgatca cgtccgtcta caacagcgac ggcaccctca
     5521 ccggggtcga caacatcacc ggcacggccg ccggagacct ctacgtcgcc gaggacggcg
     5581 ggaacatgga gatcaacatc atcacccggg acggcgtggt cgccccgatc ctgcgcgtcg
     5641 acggccaccc cgactccgag atcaccggcc cggccttctc cccggacggc agccgcctct
     5701 acttctcctc acaacggggc acgagcggcg agatcagcgg ctcgggcggc gtgacgtacg
     5761 aggtccgcgg cccgttccgc cattgagacc ctacgggccc cgggcggcaa ccggggcccg
     5821 ccccaggagg caccccgccg ccgacggtgc tacgagtgtt cggcgtggag acagcggtgg
     5881 actgccgggg ccggccaggc ggtgacttct tcgcgcgtcg tcttcaccgc cggcgggaag
     5941 cgcgggaaga cggctgtgag gaggccgcgg agcggcacca gcacgtggtg cgcgccctcg
     6001 gcgaccgcaa cgacgtcacc caactgccac ctctgctcga caagatcccg acggttgccg
     6061 gggtggccgg ccggccccgg caccgcccgg actgctcttc gctgaccgcg gctacgacca
     6121 cgccaagtac cggcgcctgc cacgcaagcg ccggatccgg ccggtgaccg ccgaacgagg
     6181 ccggccccac ggcaccggcc tgggcacctt tcgctgggtc gtcgaacggc cgatctcctg
     6241 gctgcatggc tttcgccgcc tgaggatccg cagggagaga cacgacgaca tccacaaggc
     6301 attcctcggc ctcgccacct ggctgatgac ccaccgacac gtccaacggc tttgtcaggg
     6361 ccagtcagcc cagtagccgg acgccgtccg gtacgtcgat cccgaactcc tcatcgagga
     6421 gacgccgtgc ctccctctcg ttggtcaact cccgcgccgt gaccgcgccg tcggcgcggg
     6481 tctcggtgag gtggcggccg tcgaggaaca ggtggcgacc ggaggtgagg cgctggatgt
     6541 agggacgacg gctgaacggg gatcggggat tggtggcgat gtgccagttg acgacctcga
     6601 aatcaggttg ctcgaaaggc tccatcgtga aggcgtactg cgcctcccag ccgtccgccc
     6661 tgcctgtccc ggtcatgccg tacgcctcca gcacccacat ctccagtggg ccgtcgtgcg
     6721 gtacgtgcac cagccggtgc cgacggcccg cgtcgtggaa ctccgtgccg accaccagcg
     6781 gcaccggctc caacagggcg ccgaccgagc cgaatcccac gtccgcgagg tggggccgcc
     6841 gctcgcctgg gacctcgacg agcagcgcca tgtgcgtgcg cgggcggctc tcgaagcggt
     6901 cggtgccgac cacgacccgc gcggccagca gggtcacccg gaagcccagc gcctccagga
     6961 cgcccgcgaa cagcgtgttg tgctcatagc agtagccccc acggcggccg tgcacgagct
     7021 tgaccgtcag atcggccggg tcgagggagg ggaccacacc ccgcacgggg tccaggttct
     7081 cgaacggaac ggtcagcgcg tgggccatgt ggacgccccg caacgtcgcg aggtcggccc
     7141 gccgttcgcc ctcccacccg atccgcttca gataggcatc gaggtcgaat gacgtcgtcg
     7201 gtacagtctc aggcatacct ccaccgtacg gacgcaccgc ccccgcccgc ccgcccccgc
     7261 ggccggaacc gccaccggcc cttggtccta gtactccagt cgcagttcgc tgtctctgcc
     7321 ggtcagaggg gtcttccaga gtccgttcgg ctgccgtgcc ctctggtgcc ggaagttcgt
     7381 aacctccccc gaggccgccc gtcgtgatcg tcacgcagga tgtgcggccc gacgtctgga
     7441 cggtggaact ggaagaggca ctcgtgcgga tcggtcacca gttcgggcgg gtggacctga
     7501 gacgccggta ctcccactcc tggtaacgcg agtaccagga gccaggagct ccaccccgcc
     7561 cggctgagtg gcggcgccgt ctgctcgccg ggcgtccccc agtgcggccg gtacgtccgc
     7621 aagagcggaa ggaaccatac ggggacgagg acgcgcccgg gaagtcgaac tcttgcggaa
     7681 ggacaccgcc caggaagctg cacagcgcca gccagacgcc cgtcacggct cccttcacag
     7741 gtgtcgacgg ggtcggaaac gaggtgagat gctgctgaac gcggacagga accactgggc
     7801 tccaccgatg ctgcggaagc ctttcatggc gcgttcgcgc tgccgcgtgg gctggtggga
     7861 gttctcggcc cggttgttca ggcccttgtg ggagcggtgc tcgaccgagg acatcagctc
     7921 ccggtgggcg gtgccgtagg agcgcagttt gtcggtgacc accaccctcg gcaccgagca
     7981 ggtcctcttg agcagtgtgc ggaagaaccg ccgggccgca gcggtgtccc gccggttctg
     8041 gacgaggatg tccaggacgg tgccgtcagc gtccacggcc cgccacaggt acttcagctc
     8101 gccgttgatc ttgatgaaga cctcgtccag gcgccatgtg tcgccgggac gcggggcgag
     8161 gacggctgcg tgccacagga cgtaccgggc gggtcgggag accgccggtt cagtcctgca
     8221 ggcggtactc gatgaccgcc ccggggttct ccaggccgtc gggggccgga gcgcggtcgg
     8281 cgccgagttc acggatggag cccgcggagt cggtgatggc gaagacggac ttgccgtcgg
     8341 cgctgaactc cgtgtcacgg aagcggttct gctccgtgag gagcctcgtg accttgctga
     8401 cgcgccggcc gtcgtccgtg aggtcgacac ggtagagcgt gccgtccttg agggtggtca
     8461 tcaccaggga gttctcccag cccgggatgc cctcgcccgt ggccccggcg gccttccggg
     8521 acgtcccgta gtgctcgaag ccggaggggg cgatggtggg ccagcacacc gccgcttccc
     8581 cgctcggccg gcacgccggg tcctcgaagt cgaagtccga ctccacggtg ccgaaggtgc
     8641 ggatcggctc cacgaagggc ttggtgaagt cggactcctt ccgcaccggg accgtctcgg
     8701 ggatctcgaa gttgctgaac gtcagctctt cgcagggcgt cggccacgag gcggaccagt
     8761 tgccgtagac gtaggccttg tcgtcctggt agcccgagac gttgggccag ccgtagttgc
     8821 cgccgctgcg caggacgttg atctcgtcgt cggtcttcgg gcccatctcg ttctggtaga
     8881 gcgtgccgtc ggggccgaag gccagaccct gcgcgttgcg gtggccgtag gtgtagacgt
     8941 ggctgcgcac gccggcgagg accgggttgt cctcggggat cgaaccgtcg gtgttcagcc
     9001 gcagggtctt gccccggtag gcgacccagt cccggccctg gacttcgccg gcggtgggca
     9061 gccgctgggc gtagatgggt ctgcagtagt ttccgaactg gttcgcgccc tggtcaccga
     9121 tggtgtagta cagcttgccg tccgggccca ggcgcagccg ggccgactgg tggtcgtagc
     9181 ccgacggcat gccggagatg acggtcttcg ggctgtgcag tcgcttccgc ccggagtcgt
     9241 aggtgtagcg ctcgatcttg gtacgggcct ggacgaccgg gccggggtcg acgtcgtagc
     9301 tgtaggagat gtacgcgtac acctcaccgg tcccgctccg ttccccgatg gcgaggccga
     9361 gcacgccgtc ctgccctccc tcggtgtgga cggcctgcgg caggctgagc agtgtcgtct
     9421 tggcgccgga cttcgtgtcg atgcgggtga ccttcttgcc ggtcttctcg gtggcccaca
     9481 gggatccgtc gggcgcccgt acgacctcgt aggggttgtt cagcccggtg gtcacgacac
     9541 gcttgacgaa cgtgcccgag gcgggcggtg tgctcgtgtc ggcgggaggg gagacggcgt
     9601 ccgggtcgga gttcccggag gggtctccgc cggtgatggc agcgccggtg agggaaacgc
     9661 cgagggccag gacgagtgcg gtcgtcgccg gcccgcgcag tatgcggtgc atgcggttcc
     9721 ttccagagag gttacccccg cttgagcatc gcgtggagta atcgattcag cactccgggt
     9781 gccggcccgt tctgccgttc aggtgaaaga agggccgtga ccgggaggca gggcacacaa
     9841 ggaagatcac cccggcggca tcgggacagg cttgaacctc agctcagggc tgaggagttg
     9901 agaaccgcag cgctgccttc ccgggtgggg ccgccggtct gcgcaccggt tcgcgtgcct
     9961 gcggtccgcg gtttttccgt gctccgtacg gtgtgctcgg tcaccccgtg gggccgggac
    10021 accgccgcgc gcggcggccg gcccggcggt agacccacgg cttcgggggc gccccctcct
    10081 cggagtgctc gaccagggag cggaccaggg cgtggtcggg ggagagccgg catgccggat
    10141 cggtgtgggt ggcgtcgccg gtgagcgcgt acgcctggca gcggcagccg ccgaagtccc
    10201 gtgtgcgcat gtcgcagctg cgacagggct cggtcatcca gtcggtgccg cggtagcggt
    10261 tgaacgccgg agaacggtgc cagatccagt ccagcgggtg gtcaaggacg ttcggcgggt
    10321 cgagatccgg cagggaggcc gccgccgggc agggcaggac ggtgccgtcg ggggcaacag
    10381 tgagggagac ggctccccag ccacccatgc agggcttcgc cacgccgtcg aagtggtcgg
    10441 ggacgaccca gaccagttcg ggccgtccgg gcagtccggc ccgccggcgt gcgacggtgt
    10501 cccgggcacg ggcgagctgg ccgggggtgg ggagcagcgc ggtgcggttg agcaggcccc
    10561 agccgtagaa ctgggtgttg gccagctcga tccggtccac gtcccagacc acacccaggt
    10621 cgatgacggc gtcgatcgcg tcgaggttct cgcggtgcag gacgacgttg aggcccaacg
    10681 gcagccccgc gtcgcggacc agggcggcgg ccttctcctt ggcggtgaac gacgacgggc
    10741 gtccggcgat ccggtcgttg gcccgcgggt cggcggcctg cacggacagc tggacactgc
    10801 gcagcccggc gtcggccaga gccgccagcc ggtccgcgtc caggccgacg ccgctggtca
    10861 ccagctgggt gtagatcccg gcggtttccg cggcggtagt gatctgctcg aggtcggagc
    10921 gcagcagtgg ctcaccacct gacaagtggg tgtggacgac gccgagttca ccggcctggc
    10981 gcatcacttc agcccagtgg gcggtgccca gctcgcggga gcgccgggtc aggtccaccg
    11041 ggttcgagca gtacgggcag tggagcgggc aggcgtgggt gagctcggcc aacagggccc
    11101 agggggacgc ggggacgctc atcgcagaca cccctcccgg cgcaggccgt cgaggaaggc
    11161 cgggacctcg tcggcgaccg gtgccccggg gaagcgggcg gtcagctcct cgacgatggc
    11221 ccgcacggtg cgggtgccgt cgcacagacc gaccaccacc tcgccgcggc cccgcaggac
    11281 gacgacgcgt tcgggcagga gcagcaggtc cgcgccgcgc acgggatcgt gccgcagcac
    11341 cgcggccggc accagagcag ggcgccagtc ggccgccgcc ggctgcgtgc tcatccccgc
    11401 tcccgctctc cggcggtgct cacggcgtcc agcagcgccc acaggacgtc gcacttgaag
    11461 acgagtgcgg ccaccgcccg ctcctgttcg gccggggtgc gggcccactc caggaccaga
    11521 ccgagcgcct cggaactgtc ccgccgtccc tggcggacgc ggcttcggaa gtaggcgagg
    11581 ccgtccggtt cgatccaccg gtagtggcgt tcgaaggcgt cgatacgggt gcgcatgatg
    11641 tccggggcgg ccagttcggt gagcgaggcc gccacgccct ccagcggtgt acgcagccgg
    11701 cagaagttga cgtatccctc caccgccagc cgtacgccgg gcagcacccc ctgtccgtcc
    11761 agcagcgtgc cgcggtccag gccggccgcc tcacccagcc gcagccaccg ctcgattccg
    11821 ccctggccct cctgacgccc gtcgtggtcc tcgatgcggc gcatccacat ccggcgcagc
    11881 ggcggagagt ccagctgggc gaggatcagg gcgtccttga ccgggatgtg gcgctggtag
    11941 tggaagcggt tggtgatcca gcggcggagt tccccggggc ggaggtcacc gttgtgcatg
    12001 cggatgttga agggatgccg atcgtggtag tggtcccgcg ccacgtcacg caggcgcccc
    12061 tcgaggtctg ccgggctcca gggatcggtg tgctcggtga gcggtgtggt cccggtcgtc
    12121 acggctggat caccattccg tcgtgcgcca cttccaggcc cagccgcgcg agcttcttgt
    12181 gctgcggcgc gtcggggtcc acgagcgggt tcgtgttgtt gaggtgcgtg tacaggcagc
    12241 gggcggtcag cggggcgagg agcgcggcgg tgccgcccgg accgttgatg ggcaggtgcc
    12301 ccatgccggt ggccgtgcgg tcgcggatgc ccgcacggcg gggttcctcg tcgtcccaga
    12361 aggtgccgtc gacgaggacg cagtccgcct cggcggcggc ccggtgcagg tggtcgggcc
    12421 aggcggccag ggcgggagcg tagagcacgg acgcgcccgt ggccgggtcg tacaggcgca
    12481 gcgcgaccac ccacgcctcg tcgtccggct cctcggccgc gtaccgcggc cgcttgccgg
    12541 acaccggaag ggcgctgatc cgcaggccct cgtcgtcgtc cgcggcaccc agcgggaccg
    12601 acccccggac cggcagatca cgccaggcca cctcggtgta cggggccagc accgcgtcca
    12661 ggcacagccg gtcccggacc gcgcgccgga ccgggccggt cgcgaacacc tccagcccgt
    12721 cgtgcgcctc gcgcagccgg gtgaggcccg tggtgtggtc gagttcggcg tcggtgagaa
    12781 ccagcccggc caccggggtc tgccgccgtc ccgggcccgg gtgcagagcc gggtgcgcct
    12841 cgatctgctc cccgagatcg ggcgtggcgt tcaccaggta ccagcggccc tcaccggccc
    12901 ggacggcgag cgaggcatga cgacggcgcc ggcgcggatg ggcgcgtgcc ccggagcacc
    12961 cggggcacgc gcagttccac tggggaattc cgccacccgc cgcggtgccg agcacctgca
    13021 gcagcatggc ggcgggctag cgggtcgcga gggagtaggc ggtgacctcg agtgcggtct
    13081 cgacgatcac gaactcgggt gtctgccagc cgctctcctc cacgggacgc ggcggggtct
    13141 gctcaagtcg ctcggtgtgg tcggccatga ggcgtacctc gcttttcgct acgacggccg
    13201 gggcggccgt accgaggagc tctcccttcc cggaagggag gctccaggat gccggaggga
    13261 gtcccccggc ctccccatgc aagtttcggc cacgtccccg ggacacgcca ccggtgtcca
    13321 tccgatcggt gcgcgagggg tgttcccgca tcgtggctcg cccggccggc ggggtccggg
    13381 ggctgcccgg gaccggacgg ccggcgggac ctgggggacg gccaggggcc ggaccgtccc
    13441 cgtccgtccg gtcagccgcg cgccttgtcg tcgtccaggg tgtcgaagag caggttgagg
    13501 ccctcgccca tggtggggtg ggtgaagacg gcgtcgcgga cctgctggta gggcagccgg
    13561 ccgagcatgg ccatctgcac ggcggagagg acctccccgg cgtggtggcc cagcagggcg
    13621 acgccgagga tctggtccgt tccggcgtcg acgaccgctt tccagatgcc ggttccctcg
    13681 tgcagggtct tggcgcgcgg gatggcggcg acccggagcc gggccacctt cacgtcgtgt
    13741 ccctgcgcac gagcctcggt ctccgtgagg ccgatgcggg cgagctcggg ggtggtgaag
    13801 acggtgtagg gcacgatccg gccgctggtg acggtgtcac cgccggtgag gttgtcccgc
    13861 aggacgcgga agtcgtgcca ggaggcgtgg gtgaactgtg ggctgccagc gacgtccccg
    13921 gcggcccaca catggtcggc ggtggtgcgc aggtggccgt cgacggcgac gaacccgcgg
    13981 tcggtcagcc gcacgcccgc cgcttccagt ccgaggccgg cggtgaccgg tgtccgaccg
    14041 gtggccacga gcagctcctg cccgcggacc tcggagtcgt cgtcgagggt gacgacgacg
    14101 tcaccgtggc cctcctcgcg gcgcacggca ctggcgcgcg ccccgagccg tacgtcgacg
    14161 ccctgaccgg tgagcacccg ggccacctcg tcggcgacgt cccggtcctc gcgcggcagc
    14221 aactggtcgc ggccctgcag caaggtcacg cgcgtgccga agacggcgaa catcgaggcg
    14281 aactcggcac cgacgtaccc cccgcccagg accagcagcg tctcgggcag ccgctccagg
    14341 cgcaggatcg tctccgagtc ccacacctgc gcgtcggcga tgccgggcag gtcaggcagg
    14401 gccggggtgg tcccggtgtt gatgacgacg tcccggccgc gcaccgcccg ggtggcgccg
    14461 tcggcggcgg tgatctcgac ggtccgttct cccgtgaacc gggcggtccc caggacgaag
    14521 tccatgccgg agtcggcgaa cagcttcttg tgggcctcca ccatcccgcc caccacgtcc
    14581 tccttgtgcg cgcggagcgc ttccaggtcg acggcgggct cggagccgat ctcgatgccc
    14641 atccgggctg cgtggcgtgc ggtgagcagg gtgcgggccg agccgacgag cgccttcgtg
    14701 gggatgcagg cgacgttgat gcacgtaccg ccgatcttgt cccgctccac catggccacc
    14761 ttccagcccg ccttggcgcg gtccatcgcc agcgacttcc ccgccttgcc gccgccgatc
    14821 accagcaggt cgacgtcctg gacgtccttc tcactcatgg ggacctccct ctggtgatcg
    14881 acatggcttc ttcgcgcggc gacgcacgga gttacgcggt ctccgcggaa ggaaacccga
    14941 gacgggcccg gtccttctcg gggacgaggt ccaggtatgt gccggtgtcc cgggcgatga
    15001 ccttgcggac gtaggggcag tacggcagga cggcgaggtt gcggcgccgg gcgtcgtcga
    15061 gggcctcggc gaccagctgc ccggccaggc cccggccgcc gaactcggga agggtctcgg
    15121 tgtgggtgaa tgcgatgttc ccgtcggtga gttcgtagac ggcgaagccc gcgaggcgac
    15181 cgtcgtcgtg gatctcgtag cggtgctcgg cggggttgtc gcgggtgatg gcgctcatgc
    15241 cggaccctcc tgtgcggtgg ccgcccggga cgggcgcggc gcggtggcct tctggggtgg
    15301 tactgggtgg cggctgacga tcgacacacg gttgaaggcg ttcatggtga gggcgaccca
    15361 ggccacggcg gagatctcct ccgcggtgag gtgcgcggtc gcttcggcgt agtcctggtc
    15421 ctggacgcgg gcgtccggca gcacggtgac ggactcggcg agggcgagcg cggcccgctc
    15481 ccggtcggtg aacaggccgg catcgcgcca cgcgggcagg acggcgaggc gttgcgtggt
    15541 ctcgcccccg cgcagggcgg ctcgcacgtg caggtgcagg caggaggcgc agccgttgat
    15601 ctgggagacg cgaatgttca ccagctcgac cagggtccgg tcgagtccgg ccgcgcgggc
    15661 ggtctcccgt accgtcttcg cggtctcgcg cagggcctgg tacgcctgag ggctctgccg
    15721 gtcgatccac acccggtccc cgggcggtgt cgtactcatc ggtcccccga ggcgcgctgc
    15781 cagtaggggg ccgcggtcgg gatgaggggc agggaggacg ccacgcggcc gaaacggtcg
    15841 tcctggcggg cccaggaggc gtgggcggcg tcgatctcct cgcggttgcg gccgacgaag
    15901 ttccaccaca tgaggatggg ctcggggaag ggctcgccgc ccaggagcat gacccgggcg
    15961 ggttcgtgga cgtccagggg gagttcgtcc cgtccttcgc cgaggtagcc gaggcgtccg
    16021 gggtgcaggg gcttgtcgcg cacggccacg gctccctgga ggacgacgag cgcgtactcc
    16081 cagtcgggac gcagggggac cgtggcgggt gcgcgcaggt ccagctcgac gccgacgagc
    16141 ggggtgtcgt ggcgggcggg actggccaga ccgccgaggt caccgatcag gacggtcgcg
    16201 gcgccggctt gaccgtcgag gtcggtccgc ggcagctccg catggtgctc gaaggccggt
    16261 tggctgtgcc gggtgttctc cgggagggcg gtccacatct ggatgccctc cagggtaccg
    16321 cgatagtggc cggtggcctc ctccgcgtgg gagacggcgc ggccggaggt catcagattg
    16381 agctggcccg gctcgatgac ctgttcggag ccgaggctgt cgcggtggag gacttggccg
    16441 tcggtcagcc aggtgacggt ctgcaggccg atgtgggggt gcgggccgat gtccaggccg
    16501 ctgttctcgg tgacgtcggc aggccccatg tggtcggcga agcaccaggc gcccaccgtg
    16561 cggcgccccc ggcggggcag ggcccggcgc actcggatcg tgccgacggt ggcctcgcgg
    16621 ctgtcgctca cttgcaggca gggcggttcg ggatggccgg tgtcggcctg atcggcggac
    16681 gcgtcgaccg tgctgaccgg tccgctcatc acatgacctc tttcccgtgt gtcggtgtct
    16741 tccggtgacc ggaccgccag ggaaggcggc ttgttcctgg tgcgtccgcg ggcgctggtg
    16801 tccaccatga ggtgcagtcc acggtggaag tacccgcttg agcgtgcggc aaaaggcgac
    16861 cccggccggc cggaggggtc gctcggatcc gtgacggccc gtcggccgca caacggggtg
    16921 cggccgacgg gccgggcctc ggccccctcc cggacagggc tgggtcaggc ggcggcgaga
    16981 cctgccttga ggccggaagc gatcttgacg acccgctctg cctggatccg ggcggcggtg
    17041 cgggtggtgt ccccgaccgg attgttgccc tgggcgtcga cgtgggaggt gccataaggg
    17101 ttgccgtcgg cgaacttggc gggatcggtg taaccggggg acacgaggat gccgccgaag
    17161 tggtggacgg agttgtacag cgccagcagg gtggactcct ggccgccgtg ggtggtggag
    17221 gaggcggtga agccgctgta gaccttgtcg gccagcttgc cctgggccca caggccgccg
    17281 agggtgtcga tgaactgctt gagctgcgag gcgatgttcc cgaaacgggt gggggacccg
    17341 aagatcacgg cgtcggccca ttcgatgtcg ggcggggtgg cgaccgggat gtcggcggtg
    17401 gcggcggcgt tggcggccca ggccgggttg gattcgatcg cggcctgcgg ggccagctcg
    17461 gcggccctga gcaggcggac ctcggcaccg gtcttctccg ccgcttcggc gatctcccgg
    17521 gccatctcgg ccacaacgcc ggtggaggag tagtagacga cggcgagctt gatctgggtg
    17581 ctcacggctg cggtctccgt tcggttggtg tcgtgtgtgc ggttacggct gaagatgccc
    17641 atgacagctt tcgttctggt gtcgaacgcc cgctgacggg tgttggttta accgtaaact
    17701 attatgtgga tgcctgcacc tttcagggcg agaggccgcg agcccgcgaa ttgatataat
    17761 gctcaactag atggcgatcc ggcgtcccgc ctccgccgac ggcaagggcg ccgtcatggc
    17821 ctccgctctc gacgtccgcc gcaccgacga gcgcctccgc acccgcgtcg gccggctcgg
    17881 ctcccggcgc tcctcctcct tctcccgcca cgggaatgcc gagaacaccc actgcgggct
    17941 gccgctggtc tccggcgtcg ccagcgtcgt gccgggcacc ggcttcgacg cccatcccca
    18001 ccgcgacatg gagatcatca cctgggtgct ggacggcggc ccggcccacc aggactccga
    18061 gggccacaac ggggtgatcc acccgggcct cgtccagcgg atgagtgccg gcaccgatat
    18121 ccttcacggc gagaagcgcg actcccggac tctcaccggc aagcccgccc accaggcccc
    18181 tgtccacttc atccaggtgt gggtcctccc cgacgaagct ggcatcaagc ccggatacga
    18241 gcagctcgac atcgatgacg aactggcccg cggcggctgg accactctcg cctccggctt
    18301 gccccggcgc gcgatcggca tccggcagaa gcacgccgcc ctgcacgtcg cccgtgtccg
    18361 ccccggcaag accctcctga tcaccaccgc ccccttcacc cacctcttcc tcgcccgcgg
    18421 cagccgaact ggagggtgcg ggtccgctgg cctccggtga cgcggtccgc atcaccggcg
    18481 cggagggcca gcgcatcacc gccggccccg atggcgccga ggtcccgatg cgggaaatgc
    18541 gcgccgctgt caccacggcg tgacgcgcgt accgatccgg gcagccggcc tgttctgccg
    18601 gggcatctcc tgaactgccc ggatgtgtgg ggacacgggt ctgtcggccc tggtgatcgc
    18661 tggacttgtg gcggaagagg gcgggcggcc ttcgacgcct ccgtgcgagg tgcgccacaa
    18721 ccacccctcg cgggtgagga cgccaacgtt ccgctcggca gtccgttccg caccgacgct
    18781 ctccgggcgt cggattgggt caccgagcag cgtccgacag gggtatgagc gggtggcttc
    18841 ggatgaggaa cgcgcggatc ggacacggcc atgcctcccg aggggctgct gcgggagccg
    18901 gcgctggtga tgcacatgtc ggtcacgtaa aggctctcct ccggagatcc atcctcgtgt
    18961 caatcaatta caaaccttac gcggcatctt gcgctgactt gttgacaggt gcttgagtgt
    19021 gcggcgccta ccactcccgc tcggaggggt ccactgatga gatgccccgg gttccgtcgc
    19081 actctcgcgg atccgtttcc gcatcctcga cgtctgcgac gcggcgaacc gtggctccca
    19141 ccgccggccg accggccgca gtacgcggtc ggccggcagt ccacagacca cggctccgtg
    19201 ctcagcccct cgccgaagcg cgatgggagc gcggccgatg tccggcgacg gccctctcgc
    19261 ctggctgtcc gtgcccgacg gcgtcctcgc cttccgctgc gcgacgggct ccctgtacgc
    19321 ggtgaacctc tcgccgactt gcccgaccac ctcaaagtcc tgattctcaa cggctcgctg
    19381 ggcgaccgcg agtgactccc gcagggcgcc gccgtctggc ggcgcccctg acaccggcgc
    19441 ggccgccgtc ccacccccgc cacgaaggga acgcacatgc acccgcaccc catccgtaat
    19501 gtcaggtacg cggcagtaag tgccacggtg gtcgcgttga ccgccggcat gctcgtcgcc
    19561 ctcgctcccg ctcccgcgca cgcggcgacc ggtgccaccc tgcccttcac ctccatcgag
    19621 gcggagtccg tccctaccac cggcacccgg atcggacccg actacactca gggcaccctc
    19681 gcctccgagg cttccgggcg ccgggccgtg cggctgacgg ccgggcagcg cgtcgagttc
    19741 acggtgccgc gcgcggccaa cgccgtgaac gtcgcgtaca gcgtcccgga cggtcagtcc
    19801 ggcatcctca acgtgtacgt caacggccag aagctcccca agaccctgcc ggtgacatcg
    19861 aagtactcct atgtggacac gccctggatc gccggcgcca agacgcacca cctttacgac
    19921 aacgcgcggc tgctgctcgg ccgggacgtc caagccggtg accgagttgc ggtggaggcc
    19981 gcggacgtcc aagtcaccgt cgacgtagcc gacttcgagc agaccgccgg acccgcggcc
    20041 aaaccctccg gggcggtgtc ggtcaccgac aggggcgccg accccagcgg ccggggcgac
    20101 tccacgcagg ccttccggga ggccatcgcc gccgcacagg ggggagtggt gtggatcccg
    20161 ccgggcgagt accgcctgac ctcgtcgctc agcggcgtgc agaacgtgac gatccagggt
    20221 gccggccact ggcactctgt tgtacgcgcc tcccgcttca tcgaccagcc gaactcgtcg
    20281 ggcagggtcc acatcaagga cttcgctgtc atcggtgagg tcaccgagcg tgtcgactcc
    20341 agccccgaca acttcgtcaa cggctccctc ggcccgaaca gttccgtgtc cggcatgtgg
    20401 ctccagcacc tcaaggtcgg tctgtggctc accggcaaca acgacaacct cgtcgtcgag
    20461 aacaaccgca tcctcgacac caccgccgac ggcctcaacc tcaacggcaa tgcgcgcggc
    20521 gtcagggtcc gcaacaactt cctacgcaac cagggcgacg acgcgctcgc catgtggtcg
    20581 ctgtacgcgc ccgacaccaa cagcagcttc gagaacaaca cgatctcgca gccgaacctc
    20641 gccaacggca tcgcgatcta cggcggcacc gacatcaccg tcaggaacaa cctggtcgcc
    20701 gacaccaacg ccctcggcag cggtatcgcg atctccaacc agaaattcct cgaccccttc
    20761 cacccgctgg cgggcaccat cacggtcgac ggcaacaccc tggtgcgcac gggcgccatg
    20821 aaccccaact ggaaccaccc catgggcgcc ctgcgcgtcg actcctacga cagcgccatc
    20881 gaggcccagg tccggatcac caacacgacc atcaccgaca gcccgtacag cgccttcgaa
    20941 ttcgtgtcgg gcggcgggcg cgggcacgcc gcgaagaacg tgaccgtgga cggcgccgcc
    21001 gtacggaaca ccggcacggt cgtggtccag gccgagacat cgggcgccgc caccttccgc
    21061 aacgtcacgg ccaccggcgt gggcgccgcc ggtatctaca actgcccgta cccggcgggc
    21121 tcgggtacct tcacgctcac cgacggcggc ggcaactccg gctggagcag cacctggtcg
    21181 gactgctcca cctggccgca gcccggccaa ggcagcccgg accccgaccc ggcacgcaac
    21241 ctggccaagg gacgcccggc caccgccacc ggctcccagg acgtgtacac ccccggcaag
    21301 gcggtcgacg gtgacgtgaa cacctactgg gagtccgcca accacgcctt cccgcagaac
    21361 ctcaccgtcg acttggggtc ggcgcagggc gtacgacggt tggtgctgaa gctaccgccc
    21421 gcgcaggcct ggcaggcccg cacccagacg ctgtctgtcc agggcagcac ggacggctcg
    21481 gcgtactcca cggtggtcat gccgaaggat taccgcttcg acccggcgac cggcaacacg
    21541 gtcaccgtga acctgcccgc cggtacgaac ctgcgccacc tcaggctgca cgtcaccgcg
    21601 aacaccggat ggccgggcgc gcagttcagc gaggtcgagg cgtacttgtc ctagccttcc
    21661 cgacggcccc cgcgcttcgc cgattcggcg aagcgcgggg gccgcgcacc tgccgtgggc
    21721 cgcgcgtggg gcaggtcggc ctcggccacc gcccgggtat gtggggcacg agccagagcc
    21781 tgccaccagc agggtgcgtc gaccggccgg cgatcacgct gattcacctg cggcacgatc
    21841 tgccgcacca ggcgctggag tcgagtgcgg atgccaggtc cccggtcgtc ctcgctcgcg
    21901 gctgcggaca ctggtggatg tgttcgcgta cgcccgggcc gagggcgttg aacctcgcag
    21961 agtgcggcat cgccgacctg cgggatcttg ggatacgcat ccgtaccgcg ctgcacggct
    22021 cgcaggagcg gccagccgag atggtcgaga tccccgctcc tcggttcttt cgtgctcaat
    22081 caactccctc ttgtcagaga attacaaagc tgacgcgata ta
//
