LOCUS       NZ_FNDP01000013        24399 bp    DNA     linear   CON 28-FEB-2024
DEFINITION  Pseudobutyrivibrio sp. 49, whole genome shotgun sequence.
ACCESSION   NZ_FNDP01000013
VERSION     NZ_FNDP01000013.1
KEYWORDS    WGS; RefSeq.
SOURCE      Pseudobutyrivibrio sp. 49
  ORGANISM  Pseudobutyrivibrio sp. 49
            Bacteria; Bacillota; Clostridia; Lachnospirales; Lachnospiraceae;
            Pseudobutyrivibrio.
REFERENCE   1
  AUTHORS   Varghese,N. and Submissions,S.
  TITLE     Direct Submission
  JOURNAL   Submitted (12-OCT-2016) DOE - JOINT GENOME INSTITUTE, LBNL, 2800
            Mitchell Drive, Walnut Creek, CA 94598, 94598, USA
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 02/28/2024 14:11:13
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 3,130
            CDSs (total)                      :: 3,071
            Genes (coding)                    :: 3,034
            CDSs (with protein)               :: 3,034
            Genes (RNA)                       :: 59
            rRNAs                             :: 4, 4 (16S, 23S)
            partial rRNAs                     :: 4, 4 (16S, 23S)
            tRNAs                             :: 47
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 37
            CDSs (without protein)            :: 37
            Pseudo Genes (ambiguous residues) :: 0 of 37
            Pseudo Genes (frameshifted)       :: 6 of 37
            Pseudo Genes (incomplete)         :: 31 of 37
            Pseudo Genes (internal stop)      :: 2 of 37
            Pseudo Genes (multiple problems)  :: 2 of 37
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 10:08:39
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 59210
            Orig. end                         :: 83609
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            FNDP01000013.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..24399
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="lanthipeptide-class-i"
                     /region_number="1"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..24399
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..24399
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[10000:16125](-)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..16125)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     misc_feature    complement(543..559)
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: weak, score: 21.17"
                     /tool="antismash"
     misc_feature    complement(4774..4791)
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 22.53"
                     /tool="antismash"
     misc_feature    4844..4857
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 23.34"
                     /tool="antismash"
     gene            complement(4955..5566)
                     /locus_tag="BLP54_RS11195"
                     /old_locus_tag="SAMN05421493_11346"
     CDS             complement(4955..5566)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015548677.1"
                     /locus_tag="BLP54_RS11195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05421493_11346"
                     /product="Fic family protein"
                     /protein_id="WP_090169689.1"
                     /transl_table=11
                     /translation="MMDEYYRYEYEDNGQYCYPHTHILKNKLDIHDKDELFKVEQELSS
                     ARYFELVKHPIPGDFSLDHLCAIHRYLFQDIYDWAGKIRTVDISKGTIFCLTQFIEIEF
                     KKVQEWLINNEYLQDVHDKEVMAKRLAYLIGEINMIHPFREGNGRAQRVYIEYVCKNSK
                     TFDIDFSKTTKNDMILASKESAVLNYEPFEELLYICLVEM"
     gene            complement(5571..5735)
                     /locus_tag="BLP54_RS15880"
                     /old_locus_tag="SAMN05421493_11347"
     CDS             complement(5571..5735)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="BLP54_RS15880"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="SAMN05421493_11347"
                     /product="hypothetical protein"
                     /protein_id="WP_155942184.1"
                     /transl_table=11
                     /translation="MSTDEKIASVQASFAMEDMILTAEEIERGRMIIEDKVDVEDVVRE
                     ITSRYVSVG"
     gene            complement(5825..6481)
                     /locus_tag="BLP54_RS11200"
                     /old_locus_tag="SAMN05421493_11348"
     CDS             complement(5825..6481)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF012698.4"
                     /locus_tag="BLP54_RS11200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05421493_11348"
                     /product="winged helix-turn-helix domain-containing
                     protein"
                     /protein_id="WP_090169691.1"
                     /transl_table=11
                     /translation="MEKILIVGEDLDLEKEMYTWLIPDGYEVEVLRSYEYDHLKKKKID
                     LILSEIPEEGADIYYKDLINTFDCKIIAIVREEDVDELQECGDAGVRDYIFMPIRKKEL
                     LTKVKWLVQKNSCQVENYSGVLFSNQEYKVCINNKWIYMTRNEYRICKTLAKNSEQTFT
                     KDHIYDFIYDLEKDTQIETITEYIYSIRKKCKEVAVNPIETIWGLGYRWNYEECM"
     misc_feature    6665..6680
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 20.83"
                     /tool="antismash"
     gene            complement(6699..7394)
                     /locus_tag="BLP54_RS11205"
                     /old_locus_tag="SAMN05421493_11349"
     CDS             complement(6699..7394)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="BLP54_RS11205"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="SAMN05421493_11349"
                     /product="hypothetical protein"
                     /protein_id="WP_090169693.1"
                     /transl_table=11
                     /translation="MIQAQIIKLRRTPFIWYLAITTIGIISMFVLYNLIYAWKPLGERL
                     QLLYEVYGVFLPLLHGLTVFFLINPEEQMANMYQLLSVRRRIMMFLSLTFMVWAIETIR
                     LILTFAAVGIQTGIALTGKDILLFIIGEAILSVISILFHLWVNLKFGVALSMFFAALEV
                     LQSVMYSNITIVGGWRYLPTAWAMEWKSDVVNQTWNKQLLFWGKCVMLILITTALFSAW
                     FQRWEGRKK"
     gene            complement(7391..8131)
                     /locus_tag="BLP54_RS11210"
                     /old_locus_tag="SAMN05421493_11350"
     CDS             complement(7391..8131)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="BLP54_RS11210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="SAMN05421493_11350"
                     /product="hypothetical protein"
                     /protein_id="WP_090169695.1"
                     /transl_table=11
                     /translation="MNYVIAETIKTRRTILSYFIFLAPVINVILCFLMAGSLNIQTFEL
                     YWWSTFMIPALTALFCSEHERQNKKSGNDKMLYTYPIDLYRFRNAGIAALSVKLFWVYL
                     AMAVVSVVSTFFLGVLRISYGVAVGSYLILYICSLWMVPACLLLSRYMNIYILLCVHVV
                     LNIMLPAFVADTPLWVICPYSYGPKAIEALAGIKVSGDYIAPQGVNLTVLIAVALSLVV
                     FPALSIWESKLYNRGFFEKRVKSR"
     gene            complement(8128..8829)
                     /locus_tag="BLP54_RS11215"
                     /old_locus_tag="SAMN05421493_11351"
     CDS             complement(8128..8829)
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009296714.1"
                     /locus_tag="BLP54_RS11215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05421493_11351"
                     /product="lantibiotic protection ABC transporter
                     ATP-binding protein"
                     /protein_id="WP_330386163.1"
                     /transl_table=11
                     /translation="MQMILRTENLTKKYFGFTAVENVNLEIPEGKIYGLLGPNGAGKST
                     ILKMITGIAKPTSGTIYYDEKPWTRKALADIGALIEMPPIYPNLTAYENMLVKAKLLGV
                     PKERIQEKLEITGIAKTGNKKAGDFSLGMKQRLGIALALLNDPKLLILDEPTNGLDPYG
                     IEELRELLRSFSKQGISIIMSSHILSEVQMIADAVGIISEGHVVYQGMITPEDDLNAIF
                     MEYTKNRRLVG"
     gene            complement(8955..9131)
                     /locus_tag="BLP54_RS11220"
                     /old_locus_tag="SAMN05421493_11352"
     CDS             complement(8955..9131)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR03731"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) mature_a"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:TIGR03731.1"
                     /locus_tag="BLP54_RS11220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05421493_11352"
                     /product="gallidermin/nisin family lantibiotic"
                     /protein_id="WP_090169698.1"
                     /sec_met_domain="TIGR03731 (E-value: 2.6e-16, bitscore:
                     51.5, seeds: 23, tool: rule-based-clusters)"
                     /sec_met_domain="mature_a (E-value: 1.6e-07, bitscore:
                     22.6, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEKFNNDFNLDVTVSKDDTKKADVKITSKSLCTPGCVTGLLMGCA
                     GSSATCNCSVHVG"
     CDS_motif       complement(9063..9131)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MEKFNNDFNLDVTVSKDDTKKAD"
                     /locus_tag="BLP54_RS11220_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(8955..9062)
                     /prepeptide="core"
                     /locus_tag="BLP54_RS11220_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class I"
                     /score="-0.10"
                     /molecular_weight="3223.8"
                     /monoisotopic_mass="3221.6"
                     /core_sequence="VKITSKSLCTPGCVTGLLMGCAGSSATCNCSVHVG"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MEKFNNDFNLDVTVSKDDTKKAD"
                     /leader_location="[9062:9131](-)"
                     /alternative_weights="3241.8"
                     /alternative_weights="3259.9"
                     /alternative_weights="3277.9"
                     /alternative_weights="3295.9"
     gene            complement(9204..9380)
                     /locus_tag="BLP54_RS11225"
                     /old_locus_tag="SAMN05421493_11353"
     CDS             complement(9204..9380)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR03731"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) mature_a"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:TIGR03731.1"
                     /locus_tag="BLP54_RS11225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05421493_11353"
                     /product="gallidermin/nisin family lantibiotic"
                     /protein_id="WP_090169700.1"
                     /sec_met_domain="TIGR03731 (E-value: 1.4e-16, bitscore:
                     52.4, seeds: 23, tool: rule-based-clusters)"
                     /sec_met_domain="mature_a (E-value: 1.6e-07, bitscore:
                     22.6, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEKFNNDFNLDVTVSKDDAKKADVKITSKSLCTPGCVTGLLMGCA
                     GSSATCNCSVHVG"
     CDS_motif       complement(9306..9380)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MEKFNNDFNLDVTVSKDDAKKADVK"
                     /locus_tag="BLP54_RS11225_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(9204..9305)
                     /prepeptide="core"
                     /locus_tag="BLP54_RS11225_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class I"
                     /score="-0.50"
                     /molecular_weight="2996.5"
                     /monoisotopic_mass="2994.4"
                     /core_sequence="ITSKSLCTPGCVTGLLMGCAGSSATCNCSVHVG"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MEKFNNDFNLDVTVSKDDAKKADVK"
                     /leader_location="[9305:9380](-)"
                     /alternative_weights="3014.5"
                     /alternative_weights="3032.6"
                     /alternative_weights="3050.6"
                     /alternative_weights="3068.6"
     gene            complement(9454..9630)
                     /locus_tag="BLP54_RS11230"
                     /old_locus_tag="SAMN05421493_11354"
     CDS             complement(9454..9630)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR03731"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) mature_a"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:TIGR03731.1"
                     /locus_tag="BLP54_RS11230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05421493_11354"
                     /product="gallidermin/nisin family lantibiotic"
                     /protein_id="WP_090169702.1"
                     /sec_met_domain="TIGR03731 (E-value: 1.1e-17, bitscore:
                     55.9, seeds: 23, tool: rule-based-clusters)"
                     /sec_met_domain="mature_a (E-value: 1.6e-07, bitscore:
                     22.6, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEKFNNDFNLDVTVSKDDTKKADVKITSKSLCTPGCVTGVLMGCN
                     NKTATCNCSVHVG"
     CDS_motif       complement(9562..9630)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MEKFNNDFNLDVTVSKDDTKKAD"
                     /locus_tag="BLP54_RS11230_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(9454..9561)
                     /prepeptide="core"
                     /locus_tag="BLP54_RS11230_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class I"
                     /score="-0.10"
                     /molecular_weight="3383.0"
                     /monoisotopic_mass="3380.7"
                     /core_sequence="VKITSKSLCTPGCVTGVLMGCNNKTATCNCSVHVG"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MEKFNNDFNLDVTVSKDDTKKAD"
                     /leader_location="[9561:9630](-)"
                     /alternative_weights="3401.0"
                     /alternative_weights="3419.0"
                     /alternative_weights="3437.1"
     gene            complement(9697..9870)
                     /locus_tag="BLP54_RS11235"
                     /old_locus_tag="SAMN05421493_11355"
     CDS             complement(9697..9870)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR03731"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:TIGR03731.1"
                     /locus_tag="BLP54_RS11235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05421493_11355"
                     /product="gallidermin/nisin family lantibiotic"
                     /protein_id="WP_090169704.1"
                     /sec_met_domain="TIGR03731 (E-value: 8.2e-14, bitscore:
                     43.5, seeds: 23, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAKLKNDFDLDLTVSKDNTKSADVQFKSISLCTPGCPTGILMGCH
                     KCPSGSDTVYTK"
     CDS_motif       complement(9796..9870)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MAKLKNDFDLDLTVSKDNTKSADVQ"
                     /locus_tag="BLP54_RS11235_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(9697..9795)
                     /prepeptide="core"
                     /locus_tag="BLP54_RS11235_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class I"
                     /score="3.40"
                     /molecular_weight="3188.8"
                     /monoisotopic_mass="3186.6"
                     /core_sequence="FKSISLCTPGCPTGILMGCHKCPSGSDTVYTK"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MAKLKNDFDLDLTVSKDNTKSADVQ"
                     /leader_location="[9795:9870](-)"
                     /alternative_weights="3206.8"
                     /alternative_weights="3224.8"
                     /alternative_weights="3242.8"
                     /alternative_weights="3260.8"
     gene            complement(10001..11290)
                     /locus_tag="BLP54_RS11240"
                     /old_locus_tag="SAMN05421493_11356"
     CDS             complement(10001..11290)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF017000.4"
                     /locus_tag="BLP54_RS11240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05421493_11356"
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_090169706.1"
                     /sec_met_domain="LANC_like (E-value: 2.1e-60, bitscore:
                     196.3, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDKNEVVKITVEKLMNYEEMKALMEDPANSRSALGEVIPWDHRSL
                     CAGLPGISLVFSQLLDEAEDDRMEKVAKDFIAKAVEQCNRDGYPDLSLHNGMAGLGLAI
                     TSLAQKTGGYENALKTINGAIAGNSKGLIARVDAKAIVGYDIISGLAGITSYLLLHLDD
                     DVIYHTAEGFVDALIHFTLGEGGWLVPPQYLFSDDERIMYPHGAYNSGYAHGIAGVLGV
                     LAKAYKKGIKRPGQLEAIKLIMDYYEKFKILEDDRFIWKGQLSSEEYDAVMAGKANPGE
                     GDFFRRDAWCYGAPGICYGLLQATDVVTDADIRLMAMDNMKKAIQKRDANFAPTFCHGY
                     SGLLQIAKASQNVVGQYFLQEECDVLEKLILDTFDKRLPFGFCDHEYSPELKDFRDYHE
                     PGLLNGSTGIVLALQDDGSGRGVYQSAFGL"
     gene            complement(11295..13097)
                     /locus_tag="BLP54_RS11245"
                     /old_locus_tag="SAMN05421493_11357"
     CDS             complement(11295..13097)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF012235.4"
                     /locus_tag="BLP54_RS11245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05421493_11357"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_090169708.1"
                     /transl_table=11
                     /translation="MEEQKKVTFGDILKAMKQLPGTIDILSSVDKKLFSFLVFFSLLSG
                     VLPVVSILITQGLINSIVDVANCSMQRTLILVGAFIGYNVLSYLLSEVTSYVTSIYQYK
                     LQYGLQHRMMSECSKMELKNFEQAHTYDKVEKLTTEIGYKPYQMFMAVISIFTSTMSLV
                     SVLTILVMWKPFAALGMLIIPVLAVLYYLRIGQKEFDIMWNRASGERKLWYYNHLMTHD
                     FSFKEMKVLNISDYILEKFKEASDGFVVQNKTILNQKTFFNVLYGIAIYLLSGIVIGLS
                     VVDAYLGHILVGNVMSIIRSVSMVQSESRGIMTGLYIIYSCSLYMQMLEDFLKENHKEQ
                     SEVTPIDDTIQEISMNHVSYSYDGEHNALEDINLKFKKGKRIAIVGPNGSGKSTLLKLM
                     VGLYRPEKGDIKINGVKSTALDTASYYQRISVLFQDFVKYELSLKENVGFGDIRNMDSE
                     EQIRESLKKVGTPFLEGEDGNANLQMQLGNWFENGRELSQGQWQKVALSRIYMKDADCY
                     MLDEPNAALDTLSEKDAFDRFFRLSEDKMGIYISHRLCAAKKADEIVVMQQGHVVDVGT
                     HDQLIERCKVYQDMYEAENYAEAG"
     gene            complement(13108..16125)
                     /locus_tag="BLP54_RS11250"
                     /old_locus_tag="SAMN05421493_11358"
     CDS             complement(13108..16125)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF016615.4"
                     /locus_tag="BLP54_RS11250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05421493_11358"
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_090169711.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 5.4e-114,
                     bitscore: 373.6, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 2.1e-11,
                     bitscore: 36.6, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 4.5e-32, bitscore:
                     103.8, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKIYNCEKNYIYRTPLSPAEMKETDEGLLELCSDKKFLEKVRIA
                     SRGLYESMCLLVKEPETFSKKARREVLTSVYKYYARATRRTTPFGLFAGVGVGSFEKEG
                     SLADVQHTSEKHILPDAKWLYGYVEQLEREYTKKLAWKITGAAAHDGNRITLIYTNEDS
                     ADEKSIRSTRVFEIVENYATEYTPYETLVKAIRDIYIDVGDEVIDRYLTELVENHILVS
                     VLRPTLDETKPMHYLLETCKKYGIGDVNALEDIVSGYEEYEDTDIGEGIDIYEELQEKM
                     HNLYDSDECLQVDTILQDNGVVLGYDMKTQIEDLANFFAALSAKCSIDHRVLEQYRNRF
                     IEKYGMDREVPVLEMMDATIGLGAPYGYTNPTDYQTVNNISSTTDEAVRKYLTMLYENA
                     IENGKEIRLDDPGLIELLGDVEPNKTFDSFDLYFNLTEQDGTYRLEYNGSGGSPIGGST
                     LGRFSIHDSRIREMLTNIQDRVEREGEKSCEIQFLPADTRHGNVCRSCTGRDYVMGPWV
                     QQDKEIRVEDIVVGVWNNRFYAKHIKTGEIIRFGSSNMFNKMLYPNVYRFLLEIHNDDA
                     YTWFDYPWNRLFKDCNHIPALFYKDICVTRECWNLSAQQMGLPLKGLTEEKFAEVYEKY
                     AAKHHIPTKIRLVQTDNKIQLDTSNPWGMKTLYDIFRKDPLSSLTVETSGHEELAMGDG
                     PHTMEIIANITKREKLMTPVSIPEKEVLARETYLKTPLQQWLYFKVYCKQSREEEMITM
                     ELKEFAKKMEEEHGISHFFMRYVDVRTHLRIRFGGQSENLYRAMPEILAWFNRLMAQNL
                     VGDYSIGIYEQETERYGGTALIPYAEQLFVADSSVVENLLLLHRMGRTKLDAFTMTVIS
                     VLRYTQEFFDTVDEQLDFLEQFHVATHLGAFKKDKNEMLKLCDIEQNWQGLRSGENAAV
                     MPVIDMRNHAIYQYREQLEKLGYEKKKEILYSVLHLHCNRMMGIDREAEAKAMCYAEGI
                     LHAKKYQLTQAQEEIA"
     aSDomain        complement(15445..15678)
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_BLP54_RS11250_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="8.80E-12"
                     /identifier="RREFam001.1"
                     /label="BLP54_RS11250"
                     /locus_tag="BLP54_RS11250"
                     /protein_end="227"
                     /protein_start="149"
                     /score="36.6"
                     /tool="antismash"
                     /translation="DGNRITLIYTNEDSADEKSIRSTRVFEIVENYATEYTPYETLVKA
                     IRDIYIDVGDEVIDRYLTELVENHILVSVLRPT"
     misc_feature    16217..16230
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: strong, score: 25.47"
                     /tool="antismash"
     misc_feature    16218..16231
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: medium, score: 22.54"
                     /tool="antismash"
     gene            complement(16284..17003)
                     /locus_tag="BLP54_RS11255"
                     /old_locus_tag="SAMN05421493_11359"
     CDS             complement(16284..17003)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012301.4"
                     /locus_tag="BLP54_RS11255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05421493_11359"
                     /product="LytTR family DNA-binding domain-containing
                     protein"
                     /protein_id="WP_090169713.1"
                     /transl_table=11
                     /translation="MIRVAICDDSEFMRKETDKALFDYCMAKDVDYTAKQFESGESLLK
                     EVTDFDLIFLDYQFENKGKDGMSIAREIRKINSEVTIIFLSSYTSIVYDTFEVAAFRFL
                     VKPINKEKLYSAMDDYYNSLNSDNTLAIKAEGVNHYIKENQISFVEGNGKKSIIHCINK
                     DDAIECNETLSAIEERVSPKFFFRCHKSFLVNMKYIDSFSHTDVILQDGESVMISRQKY
                     KTFCDGYSDYLARTKGF"
     misc_feature    16998..17013
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: medium, score: 23.64"
                     /tool="antismash"
     gene            complement(17022..18326)
                     /locus_tag="BLP54_RS11260"
                     /old_locus_tag="SAMN05421493_11360"
     CDS             complement(17022..18326)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF025854.4"
                     /locus_tag="BLP54_RS11260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05421493_11360"
                     /product="GHKL domain-containing protein"
                     /protein_id="WP_090169716.1"
                     /transl_table=11
                     /translation="MTHLVGIIIIIIWSLLELCNVNILVKHFLNIAPKKFRIWDFAAKL
                     LVYLLILVGYMYVVVEDSSSMVAAMFFTVLVFFKSGVLLSSFYDLKPKNLTIIAFFVEL
                     TSFIGYNISLIFDRVWTIPYEYSHLTEIIGAVFFLIVSLILLMLRKRNIFKIWIADLSS
                     IDHIHLIIILFTIGILEALIFRSDEFETFIRIIMGIVVVSTVLLIIKVIVITEKKNFLE
                     DINFLLEDQMKQTTDYYNELIEKDNQTKKFRHDIKNLLIVLHVMINEGKNEKASSYIEE
                     MQEICAQLRPKYDTGNFMADAILSAKDTKAAQYNTNIVFEGFIPAEKVKDVDMVVVLSN
                     VLDNAIEACEKIDGEKTIHINSILKKKMWVLCTDNPSGDVCIINSNKIATTKEEKTIHG
                     FGLQNIEKVAEKYNGNMQINFDNGRFSSKITFVFD"
     misc_feature    18291..18306
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 22.45"
                     /tool="antismash"
     misc_feature    18394..18407
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: strong, score: 25.18"
                     /tool="antismash"
     gene            complement(18500..18703)
                     /locus_tag="BLP54_RS11265"
     CDS             complement(18500..18703)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="BLP54_RS11265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_090169718.1"
                     /transl_table=11
                     /translation="MVKFKDEICEIYEKIDTEEALNKLTVWPSFRVRLETSKEELQKNL
                     KEIDEFLLGKYKEKSCQRANIA"
     misc_feature    18929..18947
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 24.64"
                     /tool="antismash"
     misc_feature    complement(18933..18951)
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 24.4"
                     /tool="antismash"
     gene            complement(19039..20949)
                     /locus_tag="BLP54_RS11270"
                     /old_locus_tag="SAMN05421493_11361"
     CDS             complement(19039..20949)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015548678.1"
                     /locus_tag="BLP54_RS11270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05421493_11361"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_090169720.1"
                     /transl_table=11
                     /translation="MPRGPQPGAVPKLTAEQKAKRRGVLGRLFKYIGANYWLHLIVVVT
                     GIFTAVICNAKGTAFMQTLIDSYIVPMLKSGSTDFGPLAAAIKELIAYYTIGAIATFVY
                     NYVMIFVGQGTLRSLRDDMFEKMEDLPIRYFDTHPHGDVMSIYTNDIDTMRQMISQSFP
                     QILNSAITIVTVFTYMVLTSWPLTVVTIIMIALITFTTAAVAGRSGSYFRKQQKALGAV
                     NGNIEEIMNGQKVVKVFCHEEEVMEKFNELNEELYDNAYKANRLANCIGPVNMQMGNIS
                     YLACAVVGGVLAINGWTGLTLGGLAAFLQFNRAFNMPVNQISQQFQSIVLAMAGAERVF
                     ELIDEEPEADDGYVMLVNAKEVNGEIVECEERTGMWAWKHYHKAEGTTTYVKLTGDIVF
                     DDVDFSYNPDKPVLHNIKLFATPGQKIAFVGATGAGKTTITNLISRFYDIADGKIRYDG
                     ININKIKKADLRKSLGIVLQDTHLFTGTIADNIRYGKLDATEEEVIAAAKLANADSFIR
                     RLPQGYDTVIKGDGGNLSQGQRQLLAIARAAIADPPVLILDEATSSIDTRTEKIVQDGM
                     DKLMHGRTTFVIAHRLSTIRNSDCIMVLDQGRIIERGSHDELIGEGGKYYQLYTGKIQN
                     A"
     gene            complement(20942..22714)
                     /locus_tag="BLP54_RS11275"
                     /old_locus_tag="SAMN05421493_11362"
     CDS             complement(20942..22714)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008374548.1"
                     /locus_tag="BLP54_RS11275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05421493_11362"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_090169722.1"
                     /transl_table=11
                     /translation="MVKRILQEIKEYKLAAIMTPVFMVLEVAMEMLIPLLIADLVDKGV
                     EKGNLTEIYSIGGQMLVCAVIGLFGGIMGAILGSKASAGLAKNLRKKMFENIQTFSFEN
                     IDKFSTAGLVTRLTTDVTNVQNAFIMILRMGFRAPVTVAVAMILSFRINVRLASIYLVA
                     MIVLLSVMSFVMAKARPLFVTLFKKYDALNASVQENITGMRVVKAYVREQFEKKKFTEG
                     SHGIYKAATSAEKMVAFTMPFMNVVVYTCIILISWFGAKFIVLDGTLTTGELLSLFSYC
                     MNILFSLMFFAMIFIMITMSIASMQRIYEVLEEKSTITNPENPVYEVKDGSIKFKDVVF
                     GYNKTAERPVLDHVNLEISSGETIGVLGGTGSAKSTLVSMISRLYDVNEGEVLVGGRNV
                     KEYDVETIRNEVSVVLQNNVLFSGTIAENLRWGDKNATDEEVKHAAKLACADEFIEKFP
                     DGYNTHIEQGGTNVSGGQRQRLCIARALLKKPKILILDDSTSAVDTATDAKIRKAFREE
                     IPNTTKLIIAQRINSVMDSDRIIVMDDGKIDDFGTHDELLARNQIYREIFEQQTGAGSG
                     DFDKVDEEGGKDNA"
     gene            complement(22718..23197)
                     /locus_tag="BLP54_RS11280"
                     /old_locus_tag="SAMN05421493_11363"
     CDS             complement(22718..23197)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1284:
                     transcriptional regulator, MarR family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF024212.4"
                     /locus_tag="BLP54_RS11280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05421493_11363"
                     /product="MarR family winged helix-turn-helix
                     transcriptional regulator"
                     /protein_id="WP_090169724.1"
                     /transl_table=11
                     /translation="MLADFDSRRHLGFMFDCTSREIRKAVNRGVIEIDAENCNVKNGWL
                     LGFLERQTEPVYQKDLEKIFHFPKSTLADMIQSLEKSGYIAKVPVDGDGRKKQIIVTEA
                     GKRFNDLAESQILAVDDYITSDIPPEQIEIVVEVLEKMRKNAMDYKSYVEEKKED"
     gene            23465..24025
                     /locus_tag="BLP54_RS11285"
                     /old_locus_tag="SAMN05421493_11364"
     CDS             23465..24025
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012655.4"
                     /locus_tag="BLP54_RS11285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05421493_11364"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_028247491.1"
                     /transl_table=11
                     /translation="MRERSKDLRVRRTINSIRRAFFELVLEKNYNEISITELTERAGIN
                     RKTFYLHFSSLDDFVAEIEEEIVADILDHIGSNAEAFDLAGCITNFYLYLESCNEVQQK
                     LLCDEHYSFFYESVTEGVLRSVPFSRFFERTEYPSIVRSYTISITFIYRDWLKSGKQIP
                     FDVLTAQASKIVENGYAGIIRKK"
     CDS             complement(24216..>24397)
                     /codon_start=2
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013656171.1"
                     /locus_tag="BLP54_RS15970"
                     /note="incomplete; too short partial abutting assembly gap;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05421493_11365"
                     /product="IS4/IS5 family transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="TYKANFSVAAHMCRKYYRGITSPPDLETIISRNLVPIRPDRHRVR
                     YESARIFRGFLYRVA"
     gene            complement(24216..>24399)
                     /locus_tag="BLP54_RS15970"
                     /old_locus_tag="SAMN05421493_11365"
                     /pseudo=""
ORIGIN
        1 cataggagca tgctgtctcc actctgtaac aaatacttgt ccaccatctg tcttagtatc
       61 aaagacatct gatgcatcat accagttaga gatcttcaca ttggcgtcct taatatccaa
      121 gccgacagta tattcttttc cttcaatttt acctgtgtac ttaccaataa aattgatatt
      181 aaacttctta attcccgctg tcgtagggga atccacataa tcaatagtat aatctgtgcc
      241 taattgtaaa acagaattat cactcttctt ttttatttca aggtttgtta atgcaaaagt
      301 tgcagctaca ggatatgaat atgctttatc atactttatt tcaacattgg attcattcag
      361 ttcatatttt tcaaccttga agtataccct tgcttcattt cctgcataat ttcccaagcc
      421 ccatacataa aggtatggag atgcgtctct agtggtacta ctagttaaat cataactatt
      481 tacttgaacc gtattttcgt atctataatt gtagtcagta agatacctca aatcttcaga
      541 catgcccact attcctacag ttatcggggc cttatacttg ttacctgtgt aatatacctt
      601 taaatcatca caagtatagt tccacaaagt tttgccgttt gacgtgtctt tatcatgtag
      661 ttttgcgtct ttatcagtta tcttaatcct atactcgtca ttgtttgctg aaatactgaa
      721 agtaagcctt tgtgttcctg ttaaattgtt cttaccttca ataagcacat acgctttatc
      781 tgcttctgca gaacctgatg gtgaaatatt ctgatgccaa gaaactgcat agttttcctt
      841 accaccattt ttctcatcgt taatgtcaat tgtctggcca tttattgtga ccataacttc
      901 tggtgtcttt tcttttccat catatttttg tgtctcgata gtagctgcag gagcgttatt
      961 gaccttaaaa tatgcacgcc aattagaagc agtcgttcca tttgttgctg cttcaatagt
     1021 aaatctattc tttgtgcttt cgtaggagcc agtgaaattg cctgaactac cagcacctgt
     1081 taatgcttta attacatagc tggctacacc tacattgtag ttattcgaat aaacaacctc
     1141 atagtccact ccttctctca aaacctcaac gccagaacct atttgtaccg taagctcttg
     1201 gttggtatca tcaggagtac ttgttgtaag agtaacctta tcacccgtaa atgttttctt
     1261 cgtcgttgta tttctgtccg caggagtgac ttttatatag tttgtatttg atagaggcaa
     1321 ctgattaatc ttaaatgacg caacaatatc cttagcattt ggataataat agttatctcc
     1381 atcaccactt tccttcattc tagctgtagg agaaatctta atatatttcg ttcctacatt
     1441 cttagtcata gcttgctgac agtctttatc gtcatggaag gtgactttat aataagtttc
     1501 atcatcgttg tgtggaatac gtccctcacc aggaatccat aaatatgcat ctggcgttga
     1561 atcagttcca ttatataaac gactgtaacc tgtatcctca ccatcttttg ccatttcatc
     1621 atctgaaata tagactctgg catccatcaa ataatcagct acaattttat aatctgcaga
     1681 gacatttgtt cctgattcaa aattgttgcc ctttcctgtt agcgtaagtg tgtagtcacc
     1741 tatatccttt cgccatactg taggtaaggt atattctgat gggtcaacaa taatgcttcc
     1801 taactttaca ataaaatgcg cagtatcatc ttctgtaaat ggtttagaac cggcctttag
     1861 ttcaatagtg tttcctgtgt gtgaaaattc ttctacagtt tttccactct tccattcgat
     1921 agttgtatct cttaatgact ttttctttat attaaaagta agagaaatct cgcctgtgta
     1981 gccacttgta gtcgtatcca ttgcaaaagt tattttatgc tgaccagcag aaacacctgc
     2041 aactccacct gcggaaacag cagttattgt tggtgtacat gtatctcgat ttacaatact
     2101 atttgaaagt gtttctcctg tatcaatatt gtagaattga acttctttcc atccattatt
     2161 atcatcaggt gtaagttgaa ctggagctcc tgagtacgaa agattattca atcttgtaaa
     2221 gttatcattt acctttacac ctacaatatc ctgaatctta tttccagttt tagtcaaagt
     2281 tgtatttact gtacctgtaa aattgccatg gccttcgatt tttacgtcat agagaatgcc
     2341 cgttgaagta atacttgtat ttgtaactgt aagtgagtaa tcatttgtct ggctattaag
     2401 aacataaaca ggcgcaggtg tttggccagt cgtttcaacc tttgctattt ccccattctc
     2461 aatggttata gctgcatttg tgaacatggc agctgtaagt gttattggtg taatagtaaa
     2521 atactttata aatgtgtaat taccatactt cacagttacc tttgcttttt gatcagccgt
     2581 tgatgcattc tgattgttct catatgtttt actaacattc agcgttgttg acccaatttt
     2641 ggctacaaca ttaactgtaa ttggtgatcc tgtataagta atagaaggag actcctctcc
     2701 atccaaagtt atatctacta cggaaattgc tgcataaata ggcgaaccat taccatacgc
     2761 tgctgtgata tacgcagttc ctgaactatt acatactatt gcacctgttg aatctattga
     2821 aactactgaa ggcgctgacg atgtccatgt aataattctt tctgaaccat tagaaagagt
     2881 ggctgtaaaa gtatcttcat cacccattcc gtatatatat gtagttgctg taccttctgt
     2941 tattcctgca ctaggtgctt tacttccact agcatctcca tttgtagggg caatgctggt
     3001 aatagtagtt gaatcactta tagatgtctg tgtttcgata caaccgtctg ctacaaatat
     3061 tcccttatag gaggtttttt cagtccaaag acttgtatta tcctttccgt aggtagtaaa
     3121 gtcctgattt attccataac ctatttcacc accatcaaga gcaattacat atacgccata
     3181 tgtattaccc tgtaaaacat atgcattatc attgcttgaa acacctaaat cacagtcaac
     3241 agtgtattca taccgtccct ctactgtttg tacttctact aacttgttct caacaatact
     3301 agtaccagat tcaagatcat ttttattctt tagattctta aaacttgtaa ttctaaaact
     3361 atatatgtca cctggatcac ttactttaaa gcagaattta accttattaa ctcttgtata
     3421 atttgccgtg ccttctgcaa aataaccaac cataccatat tgagatacat tgtagatatc
     3481 tataaatgta gctcctgata tcgttccaac tacatagtca gtaaagtgtt ctgcttcaaa
     3541 cgaaacatcc tcaccctcta ctacactttc aagctctgta ggggagtcat tatcttctaa
     3601 acgatataca acaatttctt cctcttcact tagatttgaa atctgattaa tatttgcaaa
     3661 tgttacatct acagcatttc catcgtcatc tggttgatat ttgtctccac cacgtctgta
     3721 aatatcaata tcaaatactt ctaatgcagt aaacgagcct tcttctatgc tttcattgat
     3781 aatgtcattg gcctttttta atggcttgct aaaaatagtt actttagcac cacgaggaat
     3841 caaaccagat actgttactg ttactccatg aacagtcttt tcgaatgtct gataaatcag
     3901 cctctcatcc tcatacagac agtcgtggca aataccattc tcatccagct ggcaagtctc
     3961 agttatctct tcaccacagt tcttgcatct cttaatgtga gtaccgtcgt tattagaaat
     4021 gtattcccac tcatgctcgc attcttcttc ctgcacataa ccgcagtgga tacactttcc
     4081 atcctcatta aaagtacaat cctctgtact ttcctcacca cacttagagc atttcttcac
     4141 atgagtacca tcattatttg aaacgtactc ccattcgtgc tcgcattctt cctcttcgtc
     4201 ttctttatcc ttctcttcgt cctcttcttc ctcgtcctct tcttcctcgt cctcttcaac
     4261 ttcttcgtca gtttcttcta tatcttcatc tggggtttct tcatctatta caggggtatc
     4321 ctctggggat atttcttcat cactaacaga cacaggttct tctgtgtttt caatctctgg
     4381 ctgtggctct tctgacacag tgatatcctc aaccggctct tctattgaag agtcttcagc
     4441 tgactgcacc tcttctactg ctgcatcttc ttcgactaca ggttcctctt ctgcatgaac
     4501 atgagcctgc tctacctgac cacagtgatc gcagtatcca tctccttctc caactggttg
     4561 aagtatgttg gctgcataag tctggtcatc cacatactcc gagcagtgat tttcttctgt
     4621 cgctattaca aacacatcat tccagatagt tgttcccagc aacagaactg tgagcgtaaa
     4681 cgccactaat cttttgattg cgtttaagtt ctctctcata ggccaattcc cctttacatg
     4741 aaaaacccca tattccatgt ctttcttgaa atttagcagc tttctgggat atttttgcac
     4801 gcaaaaataa acgcagatat actactacac tttcaatatc ggctgtaatt attattaatt
     4861 ttataatgtt aaggggtatt aactatgaaa tttctatgaa taaagtatga gggaatggct
     4921 ttaattcaac cattccctct taatagacta tcatttacat ttctaccaga catatataca
     4981 gcaattcctc aaaaggctcg tagttcaaca ccgctgattc cttgctggca agtatcatgt
     5041 cattctttgt agtttttgaa aaatcaatat caaaggtctt actgtttttg caaacatact
     5101 cgatgtacac acgctgggct cttccattgc cctctcggaa tggatgaatc atatttatct
     5161 caccgattag gtaagccaag cgctttgcca ttacctcttt atcgtgtaca tcctgaaggt
     5221 actcattatt tatgagccac tcctgaacct ttttaaattc tatctctata aactgagtaa
     5281 ggcagaaaat cgtgcctttt gaaatgtcga ctgtgcgaat ctttcccgcc cagtcgtata
     5341 tatcttgaaa caagtacctg tgaatggcgc ataggtggtc taaagaaaaa tcgccaggaa
     5401 ttggatgctt cacaagctca aagtatctgg cagagctaag ctcctgctcc accttgaaca
     5461 gttcatcctt gtcgtgaata tcaagtttgt tcttgagaat gtgagtatgt ggataacagt
     5521 actggccgtt atcttcgtac tcataacggt aatattcatc catcataggc ttatcctact
     5581 gaaacatatc tggatgtaat ctctcgaact acatcttcca catctacctt atcttcaatt
     5641 atcattctcc cacgctcaat ctcctcagca gtgagaatca tatcctccat agcaaaggat
     5701 gcctgtacac tagcgatctt ctcgtctgta gacattagtc tctccttagt tatcggctta
     5761 aaatcagtta ttaattattg gccttaagta aaacctgacc tatcctttat ttattttcat
     5821 tatatcacat acattcttcg taattccagc gatatcccaa cccccaaatg gtttctattg
     5881 ggttcaccgc tacttccttg cacttcttgc gaatagaata gatatactct gttattgttt
     5941 ctatctgagt atccttttcc aaatcataaa tgaaatcata aatatgatcc ttggtaaaag
     6001 tctgttccga attctttgcc agagtcttac agatgcgata ctcatttctg gtcatgtata
     6061 tccatttatt attaatacaa accttgtatt cctgattgct gaataaaact ccggaataat
     6121 tttctacctg acaggaattt ttttgtacca gccactttac ctttgtaaga agctccttct
     6181 tacgtattgg catgaatata taatctctaa ctcctgcatc accacactcc tgaagttcat
     6241 ccacgtcctc ttctcgaacg attgcaatta ttttgcaatc aaatgtgtta atcaaatcct
     6301 tgtaatagat gtctgctcct tcttctggga tttcagacag aatcaaatca atcttctttt
     6361 tcttaagatg gtcatactca taagaacgta gcacctcaac ttcatatcca tctggtatta
     6421 gccaggtata catttctttt tctaaatcta aatcttctcc gacaatcaaa atcttctcca
     6481 tatgctgatc tcctattctt gttattaccc acaatgtttc ttttgttcgt tacatttaga
     6541 ctagtcgttt acagtaataa ccttatcaaa gggacctgcc atatttacgt tattgacgga
     6601 agtaacacgt ttattgcctt caattgtatt tttttacact attctatgca tctaactcca
     6661 accttttacc gtttgttcca gtataatttg tcgttttatc acttctttct tccttcccag
     6721 cgctgaaacc acgcactaaa gagtgcagtt gtaatgagaa tcaacattac gcatttgccc
     6781 cagaaaagaa gctgtttatt ccaggtttga tttacgacat cactcttcca ctccattgcc
     6841 caggctgtag gtaagtatct ccaacctcca acaatggtga tgttgctata cattacagac
     6901 tgcaacactt caagtgcagc aaagaacatg gaaagggcaa cgccaaactt caaattcacc
     6961 cacaagtgga acagaatact gattacagat aatattgctt cacctatgat aaataaaagg
     7021 atgtcttttc ctgtcaaggc aattcctgtt tgaattccca ctgctgcaaa agtaagaatt
     7081 aaacgtattg tttctattgc ccacaccatg aacgtaagag agagaaacat cattattctc
     7141 ctccgtactg acagaagctg atacatattt gccatctgtt cctctggatt tataaggaaa
     7201 aatacggtca gtccatggag taatggaagg aataccccat aaacctcgta taacagctgt
     7261 aacctctctc ccaatggttt ccaggcatat atcaggttgt ataaaacaaa catgctaata
     7321 ataccaatgg ttgttattgc aagataccaa atgaatggcg tacgtcttaa tttgattatc
     7381 tgtgcttgta tcatctactc tttaccctct tctcaaaaaa tcctctgtta tataatttag
     7441 attcccaaat agataaagca gggaatacca ctaacgacaa tgccactgca attaaaactg
     7501 taagattaac tccctgtggc gcaatgtaat cgcctgatac tttgataccc gcgagtgctt
     7561 cgattgcctt tggtccatag ctgtacggac aaattaccca aagaggtgtg tctgccacaa
     7621 atgctggaag cataatattc aataccacat gtacacataa taaaatatag atgttcatgt
     7681 atctgcttag caataagcaa gcaggaacca tccaaagact acaaatataa aggattaagt
     7741 agcttcctac tgcaactcca taggaaatgc gtaatactcc aagaaagaat gttgaaacta
     7801 cagataccac tgccattgct aaatataccc aaaacagttt tacagaaaga gctgcgattc
     7861 ctgcatttct aaacctgtaa agatcgattg gataggtgta aagcatcttg tcatttccag
     7921 attttttatt ctggcgttca tgttcagagc aaaatagtgc tgttaatgct ggaatcataa
     7981 atgtagacca ccaatacaat tcgaaagttt gaatatttaa tgagcctgcc atcaagaaac
     8041 ataaaattac gttaatgact ggtgctaaaa atataaagta acttagtatt gttcttcgtg
     8101 tcttgattgt ttctgcgatt acataattca tcctactaac ctcctatttt ttgtgtactc
     8161 catgaaaata gcatttaaat catcctcagg tgtaatcatt ccctgatata ctacatgtcc
     8221 ttctgaaata atgcctactg cgtctgctat catctgaacc tcacttaaga tatggctgga
     8281 cataataata gaaataccct gctttgaaaa gcttctcagc aattcacgta gctcttcaat
     8341 accgtaaggg tccaatccat tagtaggttc atccaaaata agaagctttg gatcatttag
     8401 taaagctaaa gcaataccaa gtctctgctt cattccaaga gaaaaatctc ctgccttctt
     8461 gttgccagtt tttgcaattc ctgtaatctc aagcttctcc tgaatacgtt ccttaggtac
     8521 tcctaaaagc tttgccttca ccaacatgtt ctcatatgct gtcaggttag gataaattgg
     8581 aggcatctca attaatgctc ctatatcggc tagagccttt cttgtccatg gcttttcatc
     8641 ataatatatt gttccgctgg ttggcttcgc aattcctgta atcattttta atattgtcga
     8701 ttttcctgct ccatttggtc ccagcaatcc ataaatcttt ccttctggaa tttccagatt
     8761 cacattttca acggctgtaa agccaaaata cttttttgtt agattttctg ttcttaaaat
     8821 catctgtatc tcctccttat ttacgtctat cttaaaatct aattctaaag attttctaaa
     8881 gatttaaatt gaattttcat tttcaaaaaa aggctaatca gtaaaaacta ctgattagcc
     8941 tttcctgttt acgattaacc aacatgaact gagcagttac atgtagctga cgatccagcg
     9001 cagcccatca ataaacctgt tacacaacct ggtgtgcaaa gtgacttact tgtgatcttt
     9061 acgtctgcct tctttgtgtc atcctttgat actgttacat caagattgaa atcgttgttg
     9121 aatttttcca ttttttgttc tcctttttct gattaatatt tttagttttg tttttttagt
     9181 tacttgttag ttagtatttc cgattatcct acatgaactg agcagttaca tgtagctgac
     9241 gatccagcac agcccattaa taaacctgtt acacaacctg gtgtgcaaag tgacttactt
     9301 gtgatcttta cgtctgcctt ctttgcgtcg tcctttgata ctgttacatc aagattgaaa
     9361 tcgttgttga atttttccat ttttttgttc tccttttttc tgataaattt ttgtgttttt
     9421 gtttttaagt tatttgttag ttactatttt tgattatcca acatgaactg agcagttgca
     9481 tgtagctgtc ttattgttac agcccattaa tacacctgtt acacagcctg gtgtgcaaag
     9541 tgacttactt gtaatcttta catctgcctt ctttgtgtcg tcctttgata ctgttacatc
     9601 aagattgaaa tcgttgttga atttttccat ttttttgttc tccttttttc taataatatt
     9661 tttgttatta agttacttgt tagttcgtat ttacgattac ttggtatata ctgtgtcgct
     9721 gcctgaaggg cacttatgac aacccattaa aattcctgtt ggacagcctg gtgtacaaag
     9781 tgatatgctt ttgaactgca catctgcgct ttttgtatta tcctttgata ctgttaaatc
     9841 aagatcaaag tcgtttttta attttgccat tggttttcct cctttctatt tttttctttt
     9901 tatctatatt tatttgtcgc tttccttatc gacaagagaa atataacaag caattctcaa
     9961 gaaaatatca agattaaaat ttatttttaa aattttttat ttataatcca aaagcacttt
    10021 ggtatacacc tcttccactt ccatcatcct gcaatgccaa gactatcccc gtacttccgt
    10081 ttaaaagtcc tggttcatga taatctctga aatctttcag ctctggacta tactcatgat
    10141 cacagaatcc gaaaggaagc ctcttatcga aggtatctaa aattaatttt tccaagacgt
    10201 cacattcttc ctgtaaaaaa tactgtccca ctacattttg tgaagcctta gcaatctgta
    10261 aaagaccaga atagccatga caaaaggttg gtgcaaaatt tgcatctcgc ttctgaattg
    10321 ctttcttcat gttatccata gccataagtc taatatctgc atctgttact acatcggtag
    10381 cctgaagcaa tccgtaacat attccaggag caccatagca ccatgcatct ctacggaaaa
    10441 agtcaccttc tccaggatta gcttttcctg ccataacagc gtcatattcc tctgaagaca
    10501 actgcccttt ccaaatgaag cggtcatcct caagaatttt aaatttttca tagtaatcca
    10561 taatcaactt gatggcttcc agctgtcctg gacgcttgat gcctttttta taagccttcg
    10621 ctaatactcc caatacacct gcaatgccat gggcataccc tgaattatat gcaccgtgag
    10681 gatacatgat tcgttcatca tcgctaaaga gatattgtgg tggcactagc catcctcctt
    10741 cccctaaagt aaaatgaatt aacgcatcta caaatccctc ggctgtatga taaataacat
    10801 cgtcatccaa atgtaaaagc agatagctgg ttataccagc aagaccagaa ataatgtcat
    10861 atccaacgat tgcttttgca tctactctgg caattaatcc cttagaatta cctgcaattg
    10921 cgccattaat ggtcttaagt gcgttctcgt aaccccctgt tttttgtgcc agtgatgtaa
    10981 tagccaatcc caaaccagcc attccattgt gtagacttag atctggatag ccatctctat
    11041 tacactgctc tactgccttt gcgataaagt cttttgccac cttctccatt ctgtcatcct
    11101 ctgcttcatc cagcagctga gaaaatacca ggcttatgcc tggaagacca gcgcaaagtg
    11161 agcgatggtc ccagggtata acctctccca aggcactgcg gctattggct ggatcctcca
    11221 ttaatgcctt catttcctcg taattcataa gcttttcaac tgttattttt acaacttcgt
    11281 ttttatccat ttaattaacc tgcctctgca tagttttctg cttcatacat atcctgatat
    11341 accttgcagc gttcaattaa ctggtcgtgg gttcctacat caaccacgtg cccctgctgc
    11401 attaccacta tttcgtctgc cttctttgct gcacacaaac gatgcgaaat gtaaataccc
    11461 attttgtcct cagacagtct gaagaaacgg tcaaaggcat ccttttctga caaagtatca
    11521 agcgctgcat ttggttcatc caacatgtag cagtctgcat ccttcatata gatacgagaa
    11581 agtgccacct tctgccactg tccctgagaa agctctcggc cattttcaaa ccagttgccc
    11641 aactgcatct gtaagtttgc attgccatcc tctccctcta ggaaaggtgt gcccaccttc
    11701 tttaaggatt ctctgatttg ttcctcacta tccatgtttc taatatcacc aaagccaaca
    11761 ttttccttta atgataattc gtattttaca aagtcctgga ataatactga tatacgttga
    11821 tagtagcttg cagtatcaag agccgtactt ttaactccgt tgatcttaat atctcctttt
    11881 tctggtcgat aaagacctac catcagcttt aacaatgtac tcttaccaga accgttaggt
    11941 cccacaatag cgatgcgctt acccttctta aactttaaat ttatatcttc aagtgcattg
    12001 tgctcgccat cgtaagagta acttacatga ttcattgaaa tttcctgaat ggtgtcatct
    12061 attggtgtta cttcagactg ctccttgtgg ttttctttta aaaaatcctc cagcatctgc
    12121 atgtaaagcg agcagctgta aataatatat aatcctgtca tgatgcctct ggattcactc
    12181 tgtaccattg atacagaacg aataatactc attacattac ctaccaatat gtgtcctaaa
    12241 taagcatcta ctactgataa tccaattact attccactta agagatagat ggcaatacca
    12301 taaagcacgt tgaagaaggt tttctgatta aggattgttt tattctgtac tacaaatcca
    12361 tcagaagcct ccttgaactt ttcaaggata taatcactta tgtttaatac cttcatttcc
    12421 ttaaatgaaa aatcatgtgt cataagatgg ttgtaatacc ataattttct ctcgccactg
    12481 gcgcggttcc acatgatatc aaattccttc tgaccaatac gtaagtagta caatacagcc
    12541 aaaactggaa ttattaacat gccaagtgct gcaaatggct tccacatcac aagaatagtg
    12601 agcacagaca ctaaagacat tgttgaggta aatatagata ttaccgccat aaacatctgg
    12661 tacggtttat agcctatctc tgttgtaagc ttctctacct tgtcataagt gtgtgcctgc
    12721 tcgaaattct tcagttccat cttggaacac tcgctcatca tgcggtgttg aagtccatat
    12781 tgtaatttgt attgatagat ggaggtcaca tatgatgtga cctcagataa gagataggat
    12841 aaaacgttgt atcctatgaa tgctcccacc agaattagcg tacgctgcat cgagcaattt
    12901 gctacatcta caattgagtt aatcaaaccc tgtgtaatca gtatgctgac caccggcaat
    12961 acacctgaca gcaaactgaa aaacactaga aagctaaata attttttatc tactgaggat
    13021 aaaatatcta ttgttccagg caactgcttc attgccttta aaatatcccc aaatgttact
    13081 tttttttgtt cctccatttt ctttctccta tgcaatttct tcctgagctt gtgtcagttg
    13141 atatttcttg gcgtgtagaa tgccctcggc ataacacata gccttagctt ctgcctcgcg
    13201 atcaatgccc atcatgcgat tgcagtgcag atggagtacg ctgtataaaa tttccttttt
    13261 cttctcataa cccagcttct ccaattgttc tctatactgg tagattgcgt gatttctcat
    13321 atcaataact ggcatcacag ctgcgttttc acctgaacgt aacccttgcc aattttgttc
    13381 tatatcgcac aatttcagca tctcattttt atctttttta aaggcaccca ggtgggtagc
    13441 tacgtgaaac tgttcaagga aatccagttg ctcgtcaact gtatcaaaaa attcttgcgt
    13501 atatcttaaa actgatatta ctgtcatggt gaaggcatcc aactttgtcc gtcccatcct
    13561 gtgaagcaac agtaagtttt ctactacact actgtccgca acaaataatt gctccgcgta
    13621 tggtataaga gctgttcctc catatctttc tgtctcctgc tcatatattc cgatggaata
    13681 atctcccacc agattctgtg ccatcagtcg attgaaccaa gcgagaattt ctggcattgc
    13741 tcggtataga ttctctgact gacctccaaa acggattcgt aaatgcgtac gcacatctac
    13801 atatctcatg aagaagtggc ttataccatg ttcttcctcc atctttttgg caaactcctt
    13861 cagctccatg gtaatcattt cctcttcacg agattgttta caataaacct tgaaatacaa
    13921 ccactgctgc aatggtgttt tcagataggt ctcccttgcc agaacttcct tttccggtat
    13981 ggaaactgga gtcattaact tttctcgttt cgttatattg gcaataattt ccatggtatg
    14041 tgggccatcc cccatagcaa gctcttcatg accactggtt tctacagtta aggaactaag
    14101 tggatctttc ctaaagatat cgtagagagt cttcattccc catgggtttg aagtatccaa
    14161 ctgtatcttg ttgtctgttt gcaccagacg aatctttgtt ggtatatgat gttttgctgc
    14221 atatttttca tatacctctg cgaatttttc ctccgtcaat cccttaagtg gcaggcccat
    14281 ctgttgagct gataaattcc aacactctct ggtaacgcag atatctttat agaataaggc
    14341 tggtatatga ttgcaatctt tgaagagtcg attccaagga tagtcaaacc atgtatatgc
    14401 atcatcatta tgaatttcca gcaagaaacg atatacgttt ggatagagca tcttgttaaa
    14461 catgttgctg cttccaaagc gaataatctc acctgtctta atatgcttcg catagaatcg
    14521 gttgttccaa acaccaacaa cgatatcctc tactctaatc tccttatcct gctgcaccca
    14581 agggcccatg acgtaatctc ttccagtgca tgatcgacac acatttccat gtcgtgtatc
    14641 tgcaggcaag aactgaatct cacaggattt ctcaccctct ctttccacac ggtcttgaat
    14701 gtttgtcaac atttcacgta tacgagaatc atgaatggaa aatcttccca gggtacttcc
    14761 tccaataggt gagccaccac tgccgttata ctccagtcgg tatgtaccat cctgttccgt
    14821 caaattgaaa tataaatcaa aggaatcaaa ggttttattt ggttccacat cacccagaag
    14881 ctcaattaat cctggatcat ccagtcgaat ctcttttcca ttttcgattg cgttttcata
    14941 cagcatggtc aggtactttc tcactgcttc atctgtagtt gaactaatat tattaactgt
    15001 ctgataatcc gtaggattgg tataaccgta tggagcgcct aacccgatgg ttgcatccat
    15061 catctctaac accggcactt ctcggtccat tccatacttc tctataaatc gatttcgata
    15121 ctgttccaat actctatgat ctatactgca ctttgcagat aatgctgcaa aaaagttagc
    15181 taaatcttca atttgagttt tcatgtcata tccaagaacg actccgttat cctgtaatat
    15241 ggtatctacc tgaagacatt catcactatc atataaatta tgcatcttct cctgaagctc
    15301 ttcatatatg tctatgccct ctccgatgtc ggtatcttca tattcctcat atcctgatac
    15361 gatatcctcc aacgcattaa catcaccaat accgtacttc ttgcatgtct ccagcaaata
    15421 gtgcataggt tttgtttcat ccaaggtagg tcgtaaaaca gataccaaaa tatgattttc
    15481 taccaattcc gtcagataac gatcgataac ttcatctcct acatcaatgt agatgtctcg
    15541 aatggcttta accaaggttt cgtatggagt atattcagtt gcatagtttt ctacgatttc
    15601 aaatactcgt gtgcttcgaa tacttttctc atccgctgaa tcttcgttgg tataaatcaa
    15661 tgtgattcga ttaccatcat gtgcggctgc tcctgttatt ttccatgcca gcttcttggt
    15721 atattctcgc tccaattgct caacgtaacc atacaaccat ttggcatctg gaaggatgtg
    15781 cttttcgctg gtatgttgaa catcagcaag gcttccttcc ttttcaaagc ttccaacacc
    15841 aactcctgca aataatccaa aaggtgttgt tcttcgagtt gctctggcgt aatacttgta
    15901 gacagaagtt aatacctccc ttcgagcttt cttggaaaat gtctctggtt cctttactag
    15961 caagcacatg ctttcataaa gtcctcggct ggcgattctc accttttcaa gaaatttttt
    16021 atcggaacac agttccaata atccttcgtc agtttccttc atctccgcag gagacaatgg
    16081 tgtgcgatag atataattct tttcgcagtt ataaattttt ttcatgattt attctctcct
    16141 agtatttttt tactgttttt atgttatgga tgcagtttaa cgaagaatta tcaagaaatt
    16201 atcaagctcc aaaaaaattt tttaataaaa aaaagacact gctttcgcaa tgtcttttct
    16261 atactttatt ccatattaca aatttaaaaa ccctttgttc ttgccagata atctgaatat
    16321 ccgtcacaga aggttttata cttctgtctg ctaatcataa cagattcacc gtcctgaaga
    16381 atcacatctg tatggctaaa ggaatctatg tatttcatat ttaccaaaaa tgatttatga
    16441 catctaaaga aaaactttgg agaaactctc tcttctattg cagacaaagt ctcgttgcat
    16501 tctattgcat catccttgtt tatacaatga ataatactct tttttccatt tccctctaca
    16561 aaggaaatct gattttcttt aatgtaatgg ttaacaccct ccgcctttat tgcaagagta
    16621 ttgtcactgt tcaagctgtt atagtaatca tccattgccg aatacagctt ttccttgtta
    16681 attggcttca ccaaaaatct aaaggctgca acctcaaagg tatcataaac tatactagtg
    16741 taactactaa ggaatattat ggtaacttcg gaatttatct ttcgaatttc tctggcaatg
    16801 ctcataccat ccttaccttt gttttcaaat tgataatcaa gaaaaataag atcaaaatct
    16861 gttacttctt ttagcagact ctcaccgctt tcaaactgct tggcagtgta gtccacatct
    16921 tttgccatac aataatcaaa aagtgcctta tcagtttctt ttctcatgaa ttctgaatca
    16981 tcacatattg caactctaat cataataatt ctcccatcct gctagtcaaa tacgaatgtt
    17041 atcttcgaac taaagcgccc attatcaaaa ttgatttgca tatttccatt gtatttttcc
    17101 gccacttttt caatattctg taatccaaag ccatggattg ttttctcttc cttagtggtt
    17161 gcaatcttat tgctgtttat gatacataca tcaccactag gattatctgt gcataaaacc
    17221 cacatcttct tctttaatat agaattaata tggattgtct tttctccatc aatcttctca
    17281 caggcttcga tggcgttgtc caaaacgttg gaaagcacca caaccatgtc tacatcctta
    17341 actttttccg ctggtataaa gccctcaaaa acaatattag tattgtactg tgccgccttt
    17401 gtatccttgg cacttaagat ggcatcagcc atgaaatttc ctgtatcgta ctttggtcta
    17461 agctgagcac aaatctcctg catttcttca atataagaag atgccttttc gtttttaccc
    17521 tcgtttatca ttacatgcaa aacaataagt aaattcttta tatcatgtct gaatttcttc
    17581 gtctgattat ccttctcgat aagttcgtta taataatcag tggtctgttt catctggtct
    17641 tcaagaagaa aatttatgtc ctcaagaaaa ttctttttct ctgttataac tattaccttt
    17701 ataatcagca aaaccgttga aacaaccact attcccatta ttattctgat aaatgtttca
    17761 aactcatcag atctgaatat caaagcttcc aatataccta ttgtaaataa gataataatt
    17821 aagtggatat ggtcgatgga tgacaaatct gctatccaaa ttttaaagat atttctcttt
    17881 ctaagcatca acagaattaa agaaactatc aaaaaaaata ctgcgccaat tatttccgtt
    17941 aaatgactat attcatatgg aattgtccac actctgtcaa atattaatga aatgttataa
    18001 ccaataaaag aagtcaactc tacaaagaaa gcaataattg ttaaattttt aggtttcagg
    18061 tcgtaaaaag aactgagaag aactcccgat ttaaagaata caagaacagt aaaaaacata
    18121 gctgctacca ttgaactact gtcttctacc accacataca tatacccaac caatattaat
    18181 agatatacca gtaacttagc tgcaaaatcc catattctaa actttttagg tgctatattt
    18241 aggaaatgct ttactaatat atttacatta caaagctcca ataaactcca aataataatt
    18301 attatgattc ctactaagtg tgtcattttt ctcccaatca acctgatgta acatttttaa
    18361 aatcttggta attattgtat aacaattttc gtaattttta aataaaaaaa gctgaaatcg
    18421 ttgcgatttc agctttacat ggttcctctt atataaacgt cagttatgag gtaatcttcc
    18481 tctaaattca ttaatcgaat taagcaatat ttgctctttg acaactcttt tctttatact
    18541 tacctaaaag gaattcatcg atttctttta aatttttctg taactcttcc tttgaagtct
    18601 ctagtctaac tctgaaggat ggccataccg taagtttatt taaagcttct tctgtatcta
    18661 ttttttcata tatttcacaa atttcatctt taaatttaac cacgatattg ccatcataat
    18721 ttttctcttt atcaagaaat tcctcgaata attcttttcg ttcacatact tttttattcg
    18781 aataattaaa aactagctct tcgtgctcta atactaaaat tttaaaatac ctcctatcat
    18841 tttattagtg accgccgcca ccttttccac ccaaccaaac tggcatatgt cgtgtcctcc
    18901 tttcatttag tttcttatgt ccttgcctta tgtgtatata atatacaaat atatttcttt
    18961 ttttattttc agagtgaatg gtatgatttc gggagtgaat ggaaaaaatg gcactgcaaa
    19021 tttgcagtgc catccaattt atgcattttg aatctttcca gtatagagtt gataatactt
    19081 tccgccttcg ccaatgagct catcatgact tccgcgctcg atgattctac cctggtcaag
    19141 aaccatgata cagtccgaat tgcggatagt agaaagtctg tgagcgataa caaaggttgt
    19201 acgtccgtgc atcagcttat ccataccatc ctgtacaatc ttctctgtac gtgtatcgat
    19261 agaagatgta gcctcatcaa gaataagtac tggtggatct gcgatagcag ctcgagcaat
    19321 agcaagaagc tgtctctgac cctgtgaaag gtttccacca tcacccttga ttacggtgtc
    19381 gtaaccctgt ggcaatctac ggatgaagct atctgcgttt gcaagcttag ctgctgcaat
    19441 aacctcttct tctgtagcat ccagcttacc gtatcggata ttgtctgcaa tagtacctgt
    19501 aaaaaggtga gtatcctgaa gtacaatacc aagtgactta cgcaaatcag ccttcttaat
    19561 cttattaata ttgattccat cgtaacgaat cttaccatca gcgatatcat agaatctact
    19621 aataagattt gtgattgtag tcttacctgc tccagtagca ccaacaaagg caattttctg
    19681 acctggagta gcaaaaagct tgatgttgtg aagtactggc ttgtctgggt tgtaactaaa
    19741 gtcaacatcg tcgaatacta tgtcaccagt gagcttaacg tatgttgttg tgccctcagc
    19801 tttgtgataa tgcttccaag cccacatacc tgtacgctct tcacattcta cgatttctcc
    19861 gttaacttcc ttggcgttta caagcattac atagccatca tctgcctctg gctcctcatc
    19921 gataagctca aatacacgct cagcaccagc catagcaagt acgatagact gaaactgctg
    19981 tgaaatctga tttacaggca tattgaaggc tctgttaaac tgaaggaatg ctgcaagacc
    20041 accaagtgta agtcctgtcc aaccatttat agcaagcaca ccacctacta cggcacaagc
    20101 aaggtaactg atattaccca tctgcatgtt tacagggccg atacagtttg caaggcgatt
    20161 tgctttgtat gcattgtcgt aaagttcttc attaagctcg ttgaacttct ccattacttc
    20221 ttcttcatgg cagaatacct ttacaacctt ctgaccattc ataatctctt cgatattacc
    20281 atttactgca ccaagagcct tctgctgctt tctgaaatag ctaccagaac gaccagctac
    20341 agctgctgtt gtaaaggtaa taagggcaat cataatgata gttacgactg taagtggcca
    20401 agatgtaagc accatatatg tgaatacagt tacgatagtg attgcactgt tgagaatctg
    20461 tgggaaactc tgtgaaatca tctggcgcat tgtatcaata tcgttggtgt agattgacat
    20521 tacatcacca tgtgggtgtg tatcgaagta gcgaattggc aaatcctcca tcttctcaaa
    20581 catgtcatct ctaagggaac gaagtgtacc ctgacctacg aaaatcatta cgtagttgta
    20641 aacaaaggta gctattgcac cgattgtata gtaagcaata agctctttaa tagctgctgc
    20701 aagtggtcca aaatctgtgc taccagactt gagcattggc acgatatagg aatcaataag
    20761 agtctgcata aaggcagttc cctttgcgtt gcaaataacc gcagtaaaaa ttcctgtaac
    20821 tacaactatc agatgaagcc agtaattggc tccgatgtat ttaaacaggc ggccaaggac
    20881 gcctcttctt ttagccttct gctctgctgt cagtttagga actgctcctg gttgtggtcc
    20941 tctaggcatt gtccttacct ccttcctcgt ctactttatc gaaatcaccg cttccagcac
    21001 ctgtctgctg ctcgaaaatc tcacggtaaa tctgatttct tgctaacaat tcatcatgtg
    21061 taccaaaatc atctatcttt ccatcatcca taacaatgat tctgtctgaa tccataactg
    21121 aattgattct ctgagcaatg ataagctttg ttgtgtttgg aatctcctca cggaaagcct
    21181 ttctaatctt tgcatcagta gctgtatcta cagctgaggt tgaatcatca agaataagaa
    21241 tctttggctt cttaagaaga gctctggcaa tacaaagtct ctgacgctgt ccaccggata
    21301 catttgtacc accctgctcg atgtgtgtgt tgtaaccatc tgggaacttc tcgatgaact
    21361 cgtctgcgca ggcaagctta gctgcgtgct ttacttcttc atctgtagcg ttcttatcac
    21421 cccagcgaag gttctcagca atagttccag agaaaagaac attgttctga agaaccacag
    21481 aaacctcatt tctgattgtc tccacatcat attcttttac gtttctacca ccaacaagaa
    21541 cctcgccctc gtttacgtca taaagacgag aaatcattga aacaagggta gattttgcag
    21601 aacctgttcc accaagaaca ccgattgttt cacctgaact aatctcaaga tttacatggt
    21661 ctaatactgg acgttctgcg gtcttgttgt aaccgaaaac tacatcctta aacttgatag
    21721 agccatcctt tacctcataa actgggttct caggatttgt gattgtactc ttctcttcaa
    21781 gtacctcata tatacgctgc atgctggcaa ttgacattgt tatcataatg aaaatcatag
    21841 caaagaacat aagtgagaaa agaatgttca tacagtagct gaaaagtgag agaagctcac
    21901 cagttgtaag tgtgccatct aatactataa acttcgcacc aaaccagctg ataagaatga
    21961 tacatgtata aaccactaca ttcataaatg gcattgtgaa agctaccatc ttctcagctg
    22021 aagttgctgc cttgtaaata ccatggctgc cctctgtaaa tttcttcttc tcaaactgct
    22081 cacgtacata tgccttaaca acacgcatac cagtgatgtt ttcctgtact gacgcattta
    22141 aggcatcata cttcttaaat aaggtaacaa ataatggacg tgcctttgcc attacgaagc
    22201 tcataaccga aagtaataca atcatggcaa ccaaatatat agaagctaaa cgcacgttga
    22261 ttctgaatga aagaatcatg gcaactgcta ctgtaacagg tgctctaaag cccattcgaa
    22321 gaatcatgat aaacgcattc tgcacgtttg ttacatctgt tgtaagtctt gttacaagac
    22381 ctgctgtaga gaacttatcg atattctcaa atgagaaggt ctgaatgttc tcaaacatct
    22441 tcttacgaag gttctttgcc aaaccggctg atgccttact tcctaagatt gcacccataa
    22501 taccaccgaa caatcctatt acggcacata ccagcatctg gcctccaatg ctatatattt
    22561 ctgtaaggtt acctttttca acacccttat caacaagatc tgcaataaga agtggtataa
    22621 gcatttccat agcaacctca agaaccataa agacaggagt cataatagcc gctagcttgt
    22681 actctttaat ttcctgcaat attctcttga ccaaaatcta atcctccttc ttttcttcaa
    22741 cgtaggattt gtaatccata gcgttttttc tcattttttc aaggacctcc accacaatct
    22801 ctatctgctc tggtggaatg tcgcttgtaa tataatcatc aactgccaat atctgagatt
    22861 cagcaaggtc attaaacctt ttccccgcct cagtgacaat gatttgcttt tttctgccat
    22921 caccatcaac aggtaccttg gcaatatacc cactcttttc cagactctga atcatatctg
    22981 caagagtaga ctttggaaag tgaaatatct tttccaggtc tttttgataa actggctcag
    23041 tctgacgctc taaaaaacct aacaaccaac cgttcttgac gttgcagttt tctgcatcta
    23101 tctcgataac tcctcggttt acagcttttc taatttctcg tgatgtgcaa tcaaacataa
    23161 aacccaaatg tcgtctgcta tcaaaatcag caagcataat ttatacccct ttcccctgaa
    23221 tttagttcga atccgtatag tccgactccg aactaattca cattatacac tctaaaatgt
    23281 gttcattcaa caaacaattt ataaaaaatc tattaaaaat tccccgagag ccttttcacg
    23341 tggtatagta gacagtgaac taagaaaaga aatagttcac ttattatggg ttttagacga
    23401 catcatgtgc ttacttcata tatatgtgtt tcgaggggat aaatagtaaa taaggagtac
    23461 aaatatgaga gaaagaagta aggatttaag agttagaaga actatcaatt ctatcagacg
    23521 tgcattcttc gagctcgttt tagagaagaa ttataatgag atctctatta ccgaacttac
    23581 agaaagagct ggcattaata gaaagacctt ctatttgcac ttttcatcac ttgatgattt
    23641 cgtagctgag attgaagaag agattgtggc tgacattctc gatcatatcg gctctaatgc
    23701 agaagcattt gatctggctg gatgtattac aaacttttat ttatacctgg agtcatgtaa
    23761 tgaagtacag cagaagcttc tttgcgatga acactactca ttcttctatg agtctgttac
    23821 agagggtgtt cttcgaagcg taccattctc aagattcttc gagcgtacag aatatccttc
    23881 aatcgtacgt tcatacacca tctctattac cttcatttat agagattggc ttaagagtgg
    23941 caagcagatt ccatttgatg ttcttacagc acaggctagt aagattgttg agaatggata
    24001 tgctggaatt attagaaaga aataaatcag aatcaagaat ccaactaaaa agtggcccgg
    24061 gttatcccaa tgtcattaag ttaacattgg ggccgagggc aaaatgaatt aaagaggatg
    24121 ttggaatagt tccttcatcc tcttttttca tactttttcc acgtcaaaaa gacggattag
    24181 aatccgcctt ataatagcgt gtaaaatgta aagctttatg ctactctata aaggaaacct
    24241 ctgaaaattc ttgcagactc gtatcttaca cggtgcctgt ctggtctaat gggtacaaga
    24301 tttcttgaaa tgatggtttc caaatcaggt ggagatgtta taccacggta atactttctg
    24361 cacatgtgag cagcaactga aaagttggct ttatatgta
//
