LOCUS       NZ_FNDV01000008        10807 bp    DNA     linear   CON 11-JAN-2024
DEFINITION  Actinokineospora alba strain CPCC 201030, whole genome shotgun
            sequence.
ACCESSION   NZ_FNDV01000008
VERSION     NZ_FNDV01000008.1
KEYWORDS    WGS; RefSeq.
SOURCE      Actinokineospora alba
  ORGANISM  Actinokineospora alba
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Actinokineospora.
REFERENCE   1
  AUTHORS   Varghese,N. and Submissions,S.
  TITLE     Direct Submission
  JOURNAL   Submitted (12-OCT-2016) DOE - JOINT GENOME INSTITUTE, LBNL, 2800
            Mitchell Drive, Walnut Creek, CA 94598, 94598, USA
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 01/11/2024 04:12:26
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,667
            CDSs (total)                      :: 6,588
            Genes (coding)                    :: 6,533
            CDSs (with protein)               :: 6,533
            Genes (RNA)                       :: 79
            rRNAs                             :: 4, 4, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 1, 1 (5S, 16S, 23S)
            partial rRNAs                     :: 3, 2 (16S, 23S)
            tRNAs                             :: 65
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 55
            CDSs (without protein)            :: 55
            Pseudo Genes (ambiguous residues) :: 0 of 55
            Pseudo Genes (frameshifted)       :: 14 of 55
            Pseudo Genes (incomplete)         :: 41 of 55
            Pseudo Genes (internal stop)      :: 4 of 55
            Pseudo Genes (multiple problems)  :: 4 of 55
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 14:41:36
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 343625
            Orig. end                         :: 354432
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            FNDV01000008.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..10807
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RiPP-like"
                     /region_number="2"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..10807
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10807
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[5000:5807](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..5807)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     gene            21..1268
                     /locus_tag="BLR56_RS24475"
                     /old_locus_tag="SAMN05421871_108337"
     CDS             21..1268
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_function="GO:0008410 - CoA-transferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1189: L-carnitine dehydratase/bile acid-inducible"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018684645.1"
                     /locus_tag="BLR56_RS24475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05421871_108337"
                     /product="CoA transferase"
                     /protein_id="WP_091371261.1"
                     /transl_table=11
                     /translation="MTERILPGPFRVAHAAARCVEGVTQAAAELLRERGTDPGPVSVDV
                     RHAAAAFRSERQVLVDGRSPGDTWAPLSGDYRAADGWVKLHCNYPHHEAAVRAVLGDDV
                     AAEVARRRAHDVAEAVLAAGGAAAMLRGRDEWREHPQGRAVAAEPLVSVERIADAPARP
                     LPPADRPLVGVRVLDLTHVIAGPVCGRTLAAHGADVLHVGAAHLPTVRPLVIDTGFGKR
                     TCHLDLRADENRVTLRELLADADVMVQSFRPDTFATKGFGPQDLPPGVVLVSLSAYGHS
                     GPWRDRRGFDSLVQLATGIARESDGKLVSLPAQALDHGTGWLAAYGVIDALRRRSVEGG
                     TWHVRVSLARTALWLDELGRVDSAEEPGFAEPYLSEMDSDFGLVRHVRFPGAMPGSPPG
                     YGHGPRTPGGDPASWW"
     misc_feature    complement(22..36)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.99"
                     /tool="antismash"
     gene            complement(1271..4363)
                     /locus_tag="BLR56_RS24480"
                     /old_locus_tag="SAMN05421871_108338"
     CDS             complement(1271..4363)
                     /EC_number="3.4.-.-"
                     /GO_function="GO:0008236 - serine-type peptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S8"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1075: alkaline serine protease, subtilase family"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012311.4"
                     /locus_tag="BLR56_RS24480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05421871_108338"
                     /product="S8 family peptidase"
                     /protein_id="WP_166658196.1"
                     /sec_met_domain="Peptidase_S8 (E-value: 3.7e-64, bitscore:
                     211.2, seeds: 43, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQPSRQPSNDAKAVTLITGDRVLLSAGKPAVLPGKGRERIAFRTY
                     TVAGRLNVIPADALPLVSSGKLDPRLFDVTGLLDAGYGDSRGDLPLILTGPTPRSAGVR
                     TVRELPSAGARAVAAEKSSLGESWRALAAGPGKVWLDARHKANLDRSTAQIGAPSAWQA
                     GLTGAGVTVAVLDTGVDQTHPDLAGREVGEQNFTDSADAVDRVGHGTHVGSTIAGGGAK
                     YKGVAHGAKLLDGKVLSDQGWGQESWIIAGMEWAAEQGADIVNLSLGGQDTAEVDPLEA
                     AVNRLTAERGTLFVIAAGNSGPSAGSVGSPGSAEAALTVGSVERDDTLSFFSSRGPRVG
                     DGGIKPDVTAPGSQIVAAQAKEGSIGTPVEPGYVSMSGTSMATPHVAGAAALLVQKNPQ
                     WTAGQLKAALTASARPTAGESAYAQGSGRIDVPKSLAQNVTSEPTSVSFGVPQWPHDDD
                     QPVSKEITYRNGGTAPVTLDLTADFVGPDGKPAPAGMIALSRDRVEVPAGGTATVGVTS
                     DTRLGSVDGAYSGAVVARSGETAVRTPVGVDREVESYQLKATFLGLDGKPSPDAYTLLF
                     GLDSGQPYFVNSPDGVVTRRLPKGRYLIDTFFSYETASHVLADPGFTLTKDTEIVVDAR
                     ITKQLKVVAPDPAAVSVLASAGYELTTEHGSIGVAALADSAEQIYTAHLGAELPADKFL
                     WTLNTSWMAGKDFYGLAHFQPKSVPTGLEKTYRPADMATVRTALGQPTAQAANGLRVTF
                     PLYSDGRGSSWAIGREITMPGGLTEHFSTENTQWESEVMIGEPPAILGAFRSAPKQLRA
                     GRTYQERMAGAIFGPALPRSTYPWAERFGDEIGFNIGLFGDGAGNAGFTAVTSGNTTLY
                     RDGVKLGASPDAGYGVFPVPAAKGAYRLTTEGVRGEVFDVSTRVSAAWTFTSASGDKAI
                     PLSVVRFHGALDESNSARAGRPFLLPVSMQLEDGSTVTPRKLGVEVSYDEGKTWRRATV
                     ANNSALLFHPAEAKSVSLRAKAEDGRGGTVEQTIIRAYKLK"
     misc_feature    4530..4544
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 15.51"
                     /tool="antismash"
     misc_feature    4535..4550
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 17.42"
                     /tool="antismash"
     misc_feature    complement(4538..4553)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 17.06"
                     /tool="antismash"
     gene            complement(4669..5004)
                     /locus_tag="BLR56_RS24485"
                     /old_locus_tag="SAMN05421871_108339"
     CDS             complement(4669..5004)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020671914.1"
                     /locus_tag="BLR56_RS24485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05421871_108339"
                     /product="hypothetical protein"
                     /protein_id="WP_091371265.1"
                     /transl_table=11
                     /translation="MSGARERLAAEQAALLRALLADGPAPAGFDEHALRVEADALLAKR
                     RRVVAQLAPEVAGDLDERYRPLFDEYARAHPRTVGSRARDDAAAFTKWLIAGGHVTEPK
                     RRWWRRT"
     gene            complement(5001..5807)
                     /locus_tag="BLR56_RS24490"
                     /old_locus_tag="SAMN05421871_108340"
     CDS             complement(5001..5807)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: DUF692"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005157007.1"
                     /locus_tag="BLR56_RS24490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05421871_108340"
                     /product="DUF692 domain-containing protein"
                     /protein_id="WP_091371468.1"
                     /sec_met_domain="DUF692 (E-value: 5.2e-84, bitscore: 276.0,
                     seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGELGVGIGWRSEIDLTVERMPGIDFVEVVAENIHHDHLPESLRV
                     LLDRGIPVLPHAVSLSLGGADPVDGARIDHLAAVTDALGAPMASDHVCFVRAGGLDSGH
                     LMPVPRTRDALDVLTANVKTAQAALGVPLALENIAALLRWPDEELTEAQFLTELVERTG
                     CLLLVDVANMWANGRNLGQDPADLLDGLPLDRIAYVHVAGGVERDGVYHDTHAHPVPSG
                     VLEVLRELCSRVRPPGVLLERDDLYPTDSALLAELEAIRGVLAATA"
     gene            complement(5825..6745)
                     /locus_tag="BLR56_RS24495"
                     /old_locus_tag="SAMN05421871_108341"
     CDS             complement(5825..6745)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:TIGR04222.1"
                     /locus_tag="BLR56_RS24495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05421871_108341"
                     /product="TIGR04222 domain-containing membrane protein"
                     /protein_id="WP_166658195.1"
                     /transl_table=11
                     /translation="MNEPWGIAGPDFLRIYVVAFAFALLFALAVRIMVRAGSADSRAAS
                     GAIGPGQLSLDELAYLAGGPRRVVETAVARLIDRDKVRPSRKGTVRVVEGSTATDPIDQ
                     AVLADIKRNQERSIGLLVDKVGRRDVVRKLGEALARKGLLVGEDAARARWGVLPMIVLF
                     VVGGARWTNGLAEGRPIGWLTVALAATAVVTVLLYRKAVPERTYAAERLLAEARGTRSS
                     KQVNDAAVLYGGAAGLAGVVGVVALSGLAAHPDTELASALESQKQAIAASNSGSSGCGS
                     GPSSGGGSSCGSSGGGGCGGGGCGG"
     misc_feature    complement(6701..6715)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 16.05"
                     /tool="antismash"
     misc_feature    complement(6801..6816)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: medium, score: 16.67"
                     /tool="antismash"
     gene            complement(6857..7300)
                     /gene="msrB"
                     /locus_tag="BLR56_RS24500"
                     /old_locus_tag="SAMN05421871_108342"
     CDS             complement(6857..7300)
                     /EC_number="1.8.4.12"
                     /GO_function="GO:0033743 - peptide-methionine (R)-S-oxide
                     reductase activity [Evidence IEA]"
                     /GO_process="GO:0006979 - response to oxidative stress
                     [Evidence IEA]"
                     /GO_process="GO:0030091 - protein repair [Evidence IEA]"
                     /codon_start=1
                     /gene="msrB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018684638.1"
                     /locus_tag="BLR56_RS24500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05421871_108342"
                     /product="peptide-methionine (R)-S-oxide reductase MsrB"
                     /protein_id="WP_091371268.1"
                     /transl_table=11
                     /translation="MKPVVGATPRVVKSEQEWRAQLNPEEFAVLRQAGTERPFTGEYTD
                     SKTVGVYQCRACGAELFRSDTKFESHCGWPSFFSPLAGESVVLREDRQFGSVRTEVLCA
                     SCHSHLGHVFEGEGYPTPTDQRYCINSISLRLVPDTSSPAQEA"
     gene            complement(7329..7655)
                     /locus_tag="BLR56_RS24505"
                     /old_locus_tag="SAMN05421871_108343"
     CDS             complement(7329..7655)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018684637.1"
                     /locus_tag="BLR56_RS24505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05421871_108343"
                     /product="hypothetical protein"
                     /protein_id="WP_091371270.1"
                     /transl_table=11
                     /translation="MVATGSSGTADDEPRPGPPGRFADDLIGLDPDDPEARAFAEHLDR
                     VERVRPGYTVEGYIGGVGDFADAANRLGGHYRVTAGIVVTLILLGVIVAAWDTLVFIFS
                     MLLG"
     gene            complement(7680..9023)
                     /gene="hisS"
                     /locus_tag="BLR56_RS24510"
                     /old_locus_tag="SAMN05421871_108344"
     CDS             complement(7680..9023)
                     /EC_number="6.1.1.21"
                     /GO_component="GO:0005737 - cytoplasm [Evidence IEA]"
                     /GO_function="GO:0004821 - histidine-tRNA ligase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006427 - histidyl-tRNA aminoacylation
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="hisS"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018684636.1"
                     /locus_tag="BLR56_RS24510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05421871_108344"
                     /product="histidine--tRNA ligase"
                     /protein_id="WP_228769725.1"
                     /transl_table=11
                     /translation="MRGSIHSPGTVLLVIATAICEEPVPVKMDNSPARGTRDLLPATVA
                     VRDHVLAQITEVYHRFGYQRIETPALENIERLTGGQGGENEKLIYRVLRRGLDETVAAD
                     TTLGELVDLGLRYDLTVPLTRFYGNNQATLPQPFRSFQVGPVWRAERPQKGRYRQFYQC
                     DIDMLGEESVLAEVELIEATTEALAAVGLDGTTVRVSDRRFLSALAEGIGLPESEWTGL
                     FITLDKLDKVGWDGVRAELAGRGLETDRIDQLQASITGLQGIDPAKLADQLTASVPGLS
                     DEVVADLSATADALRSLAETRPLTWEFDPTLVRGMGYYTGQIFEIVHPGSSGSVAGGGR
                     YDKLIGRSLGRDVPACGFSIGFERIVDLLEGQARGESVAVLYEADVPLARVTGTARELR
                     ADGRPVSPIRRRGKFGAQLGRLEEWGFTSFVHLKSEQAEIEERKLGDR"
     gene            9053..10102
                     /gene="ligD"
                     /locus_tag="BLR56_RS24515"
                     /old_locus_tag="SAMN05421871_108345"
     CDS             9053..10102
                     /EC_number="6.5.1.1"
                     /codon_start=1
                     /gene="ligD"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015099314.1"
                     /locus_tag="BLR56_RS24515"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05421871_108345"
                     /product="non-homologous end-joining DNA ligase"
                     /protein_id="WP_091371274.1"
                     /transl_table=11
                     /translation="MATEAVEITVGDRAVRVSNPDKPYFPELGLTKRQIVEYFLSVGDG
                     ILGALRERPTTLERWPGGVFEGAKLSTRADNRGDAFYQKRIPKGAPDYVETARIAFPSG
                     RSADEVCPTELAVVAWAVNLGTLTFHPWPVSRADVDRPDQLRIDLDPQPGTDFTDAVKV
                     AFTVRELLAEHGIEAFPKTSGGRGVHLYVPIEPRWTFVEVRRALIAFGRSVARRMPDEV
                     TVNWWKEERGSRIFIDYNQMARDRTIASAYSIRPTQRALVSAPVTWDELGDVHPEDFSV
                     LTMPARFAQVGDLHAPVAEKAFSLEPLIELAERDERDNGLGDLPYPPDYPKMPGEPKRV
                     QPSKARDDT"
ORIGIN
        1 tgtcgtgaag cgggagggtc atgaccgagc gcatcctgcc cgggccgttc cgggtcgccc
       61 atgccgccgc ccgctgtgtc gagggggtga cgcaggcagc ggccgagttg ctgcgggagc
      121 ggggaaccga tcccggtccc gtatcggttg acgtcaggca tgcggccgcc gcattccgca
      181 gtgagcggca ggtgctcgtc gacggccgct cgcccggaga cacgtgggct ccactgtccg
      241 gcgattaccg tgccgccgac ggctgggtga agctgcactg caactacccg caccacgaag
      301 ccgccgttcg cgcggtcctc ggtgacgacg tggcggccga ggtggcgcgc aggcgggccc
      361 acgacgtggc ggaggcggtg ctcgccgcgg gtggggcggc cgcgatgctg cgcgggcgcg
      421 acgagtggcg ggagcacccg caaggcagag ctgtcgccgc tgagccgttg gtctcggtcg
      481 agcggatcgc cgacgcgcct gcccggccgc ttccacccgc tgaccggccc ctcgtcggtg
      541 tccgcgtcct cgacctcacc catgtcatcg ccggccccgt ctgcggccgc accctcgccg
      601 cccatggcgc cgacgtcctg catgtcggcg ccgcgcacct gccgaccgtg cgccccttgg
      661 tgatcgacac cggcttcggc aaacgcacct gccacctcga ccttcgcgcc gacgagaatc
      721 gagtgaccct gcgggaactc ctcgccgacg ccgacgtcat ggtgcagtcg ttccgcccgg
      781 acaccttcgc caccaaggga ttcggcccgc aagacctgcc tccgggcgtg gtcctggtca
      841 gcctgtccgc gtacggccac agtggaccgt ggcgggatcg acgcggattc gacagcctcg
      901 tccaactcgc cacaggcatc gccagggaat ccgacgggaa gctggtctcc ctgcctgcgc
      961 aagcgcttga ccacgggacc ggctggctcg cggcctacgg ggtaatcgac gccctgcgga
     1021 gaaggtcggt cgaaggcggc acctggcacg tccgcgtttc cctggcccgt accgcgttgt
     1081 ggctcgacga actcggtcga gtggactccg ccgaggaacc cggtttcgcc gaaccgtacc
     1141 tgtccgaaat ggacagtgac ttcggactcg tccggcacgt ccgcttcccc ggcgcgatgc
     1201 cggggtcgcc cccgggctac ggtcacggac cccgtacgcc cggcggcgac cccgcatcct
     1261 ggtggtagac ctacttcaac ttgtacgccc ggatgatcgt ctgctcgacc gtcccgcccc
     1321 gcccgtcctc cgccttggcc cgcagtgaca cggacttcgc ctcagccgga tggaagagca
     1381 acgcgctgtt gttggccaca gtcgcccgcc gccacgtctt cccctcgtcg taggacactt
     1441 cgacgccgag tttgcgtggt gtgacagtcg atccgtcttc gagctgcatg ctcaccggca
     1501 gcaggaacgg cctgcccgcg cgggcgctgt tgctctcgtc caaggcaccg tggaaccgaa
     1561 ccaccgacag cgggatggcc ttgtccccgg acgccgaggt gaacgtccat gccgcggaca
     1621 ccctggtgct cacgtcgaac acctcgcccc gcaccccttc cgtggtgagc cggtacgccc
     1681 ccttcgcggc gggcaccggg aacaccccgt agccggcgtc cgggctcgcc ccgagcttga
     1741 caccatcgcg gtagagggtc gtgttgccgg aggtcacggc ggtgaatccg gcgttgcccg
     1801 cgccatcgcc gaacaggccg atgttgaacc cgatctcgtc accgaaccgt tccgcccatg
     1861 ggtacgtcga ccgcggcagc gcaggcccga agatcgcccc ggccatccgc tcctggtagg
     1921 tccgaccagc acgcaattgt tttggcgccg aacggaacgc acccaggatc gcaggcggct
     1981 cgccgatcat cacctcggat tcccactgcg tgttctcggt ggagaagtgc tcggtgaggc
     2041 cgcccggcat cgtgatctcg cgcccgatcg cccaactgct gccccgcccg tccgagtaga
     2101 gggggaacgt cacccgaagg ccgttcgccg cctgggcggt cggctgaccg agcgcggtgc
     2161 gcaccgtcgc catgtcggcg ggccggtacg tcttctccag cccggtcggc acggacttcg
     2221 gctggaaatg cgccaggccg tagaagtcct tgcccgccat ccacgacgtg ttcaacgtcc
     2281 agaggaactt gtccgcgggc agttccgccc ccaggtgggc ggtgtagatc tgctccgcgg
     2341 agtccgcgag cgcggccacc ccgatcgacc cgtgctccgt ggtgagttca taacccgcgg
     2401 aggccaggac cgacaccgcc gccggatccg gcgcgacgac cttgagctgc ttggtgatcc
     2461 gggcgtcgac cacgatttcc gtgtccttgg tcagcgtgaa ccccggatcg gcgagcacgt
     2521 gtgaagccgt ctcgtagctg aagaacgtgt cgatcagata ccggcccttc ggcagtcgcc
     2581 gcgtgaccac accgtccgga ctgttcacaa agtacggctg acccgagtcg agtccgaaga
     2641 gcagcgtgta cgcgtccggc gacggtttgc cgtcgagacc gaggaaggtc gccttgagct
     2701 ggtagctctc gacctcgcgg tccaccccga ctggggtgcg caccgccgtc tcgccggacc
     2761 tcgcgacgac cgcgccggag tacgcgccgt cgaccgagcc gagcctcgtg tcggaggtga
     2821 cacccaccgt cgcggtgccg cccgcgggaa cctcgacccg gtcgcgcgac aacgcgatca
     2881 tcccggcggg cgcgggcttc ccatcgggac cgacaaagtc cgccgtcagg tccagggtca
     2941 ccggcgcggt tccgccattg cggtaggtga tctccttcga caccggctgg tcgtcgtcat
     3001 gcggccactg cggcacgccg aagctgaccg acgtcggctc gctggtcacg ttctgcgcca
     3061 acgacttcgg cacatcgatc cgcccggagc cctgcgcgta cgctgactcc ccagccgtcg
     3121 gccgagccga cgcggtcagt gctgccttga gctgccccgc cgtccactgt ggattcttct
     3181 ggaccagcag cgcggccgcg cccgcgacgt gcggggtggc catcgaggtg cccgacatcg
     3241 acacgtagcc cggctcgacg ggagtcccga tggaaccctc tttcgcctgc gcggcaacga
     3301 tctgcgagcc cggcgcggtc acgtccggct tgatgccccc gtcgcccacg cgcggtcccc
     3361 ggctggagaa gaacgagagc gtgtcgtcgc gctcgaccga gccgaccgtc agcgccgcct
     3421 ccgcactgcc cggcgaaccc accgaacccg ccgacggacc ggagttgccc gccgcgatga
     3481 cgaacagggt gccgcgttcg gccgtgagcc ggttgaccgc cgcttccagc gggtccacct
     3541 cggctgtgtc ctgcccgccc aggctcaggt tgacgatgtc ggccccctgc tcggcggccc
     3601 actccatgcc cgcgatgatc cacgactcct ggccccagcc ctggtcggag agcaccttgc
     3661 cgtcgagcag cttcgcgccg tgcgccacgc ctttgtactt cgccccgccg cccgcgatcg
     3721 tcgatccgac gtgcgtgccg tgcccgacgc ggtccaccgc gtcggcggag tcggtgaagt
     3781 tttgttcccc gacttcgcgg cccgcgaggt ccgggtgggt ctggtcgacc ccggtgtcca
     3841 ggaccgcgac ggtcaccccg gctccggtca ggcccgcctg ccacgccgat ggcgcgccga
     3901 tctgggccgt gctgcggtcg aggttggcct tgtgccgggc gtcgagccac accttgcccg
     3961 ggcccgccgc aagcgcccgc cacgactcgc ccagcgacga cttctcggcg gcgaccgcgc
     4021 gtgcccccgc cgacggcagt tcacgcacgg tccgaacgcc cgccgagcgc ggcgtcggac
     4081 cggtgaggat cagcggcagg tcgcccctgc tgtcgccgta gcccgcgtcg agcaggccgg
     4141 tcacgtcgaa cagccgcggg tcgagcttgc ctgaggagac cagcggcaac gcgtcggccg
     4201 ggatgacgtt gagccgtccg gccacggtgt acgtgcggaa cgcgatccgt tcgcggccct
     4261 ttccgggcag cacggcgggt ttgcccgccg aaagcagcac ccggtcgccg gtgatcaagg
     4321 tgaccgcctt ggcgtcgttc gacggttgcc tcgatggctg caccgtttga gctgtggcgg
     4381 cggtcgagcc cgcggccacc aatccgatcg cgataacgag agaaattgtc cgtttcatct
     4441 gtgtaccagc ccccaccggt caggaaaatg acaacgcaca agggccgacg acaggtgacg
     4501 cgcagttccc ccagaaatca agccccagta atttcaagtt aatgattttc ggccgcccgc
     4561 gcatcatccg attgggtggc cgggtggtgc cgacaggggt cgacaccacc cgggtgcccg
     4621 gccaccggct cgcgagaacc cgcgaaaacc gttgccccgg ccgggaactc aggtgcgacg
     4681 ccaccaccgg cgtttgggtt ccgtcacgtg accaccggcg atgagccact tggtgaacgc
     4741 cgccgcgtcg tcgcgggcac gggagcccac ggtgcgcgga tgggcgcgcg cgtactcgtc
     4801 gaagagggga cggtagcgct catccaggtc gcccgcgacc tcgggtgcga gctgggcgac
     4861 gacgcgcctg cgcttggcca gcagggcatc ggcctccacc cgcagggcgt gctcgtcgaa
     4921 ccccgcgggg gccgggccgt cggccagcag tgcccgcagc agcgcggcct gctccgcggc
     4981 gagtcgctcg cgcgcgccgc tcacgccgtg gccgcgagga cgccgcggat ggcttcgagt
     5041 tcggccagca gggcggaatc cgtcgggtac aggtcgtcgc gttccaacag gacacccggc
     5101 ggccggaccc gggaacacag ctcccgcaac acttccagca ccccggacgg caccgggtgg
     5161 gcgtgcgtgt cgtggtagac gccgtcgcgt tcgaccccgc ccgccacgtg cacgtaggcg
     5221 atccggtcga gcggcagccc gtcgaggagg tcggctgggt cctgccccag gttgcggccg
     5281 ttggcccaca tgttggccac atcgaccagc agcagacatc cggtccgctc gaccagctcg
     5341 gtgaggaact gcgcctcggt cagctcctcg tcgggccacc gcagcagggc cgcgatgttc
     5401 tccaacgcga gcggcacccc cagcgccgct tgtgcggtct tcacattcgc ggtcaacaca
     5461 tcgagggcgt cgcgggtgcg cggcaccggc atgaggtgcc ccgagtcgag cccgcccgcc
     5521 cggacgaaac agacatggtc gctggccatc ggcgcgccga gcgcgtcggt caccgcggcg
     5581 aggtggtcga tccgggctcc gtcgaccgga tcggctccgc cgagcgagag ggagacggcg
     5641 tgggggagca cggggatgcc ccggtccagc aggacccgca gcgactccgg gaggtggtcg
     5701 tggtggatgt tctccgccac gacctccacg aagtcgattc ccggcatccg ctccacggtc
     5761 aggtcgatct ccgaccgcca gccgatgccc accccgagct cacccacacc gatcaccctc
     5821 tatctcatcc gccgcaaccg ccgccgccac agccaccccc gccgctgctg ccgcacgacg
     5881 atcctccccc ggatgagggc cccgaaccac accccgacga ccccgagttg ctcgcggcga
     5941 tcgcctgctt ctgcgattcc aacgccgagg ccaactcggt gtccgggtgg gcggcgaggc
     6001 cgctgagcgc gaccacgccg accaccccgg ccagccccgc cgcacccccg tacagcaccg
     6061 ccgcgtcgtt cacctgcttc gacgaccggg ttccccgggc ctcggcgagc agccgttccg
     6121 ccgcgtaggt ccgttccggc accgccttgc ggtacagcag gaccgtcacc accgcggtgg
     6181 cggccagggc gaccgtgagc cagccgatcg gccgtccctc ggccaacccg ttcgtccacc
     6241 gcgcgccccc gaccacgaac agcacgatca tcggcaggac accccatcgg gcccgagccg
     6301 cgtcctcgcc gacgagcaac cccttgcggg ccaaggcttc gccgagcttg cgcacgacgt
     6361 cgcgccgacc gaccttgtcg acgagcagac cgatactgcg ttcctggttg cgcttgatgt
     6421 ccgccagcac cgcctggtcg atcgggtccg tcgcggtgga cccctcgacc acccgcacgg
     6481 ttccctttcg gctcggccgg accttgtcgc ggtcgatcaa cctggcgacg gcggtctcga
     6541 cgacgcgccg aggcccgccc gccaggtacg ccagctcgtc gagcgagagc tgacccggcc
     6601 cgatcgcccc actcgccgcc cgcgaatcgg cggaccccgc gcggaccatg atccgcaccg
     6661 ccaaagcgaa cagcaaagcg aaagcgaaag cgaccacgta gattctcagg aaatccggtc
     6721 ccgcgattcc ccacggttca ttcatcatct cgatcccccc tcacgccaag ttgccctgac
     6781 gtgacacatg ctgttcgcgg tgtgaccgcg agcacaaggg accttgattt agatttaggg
     6841 aagccgtggg tcagatttag gcttcttgag ccggacttga ggtgtcgggc accaggcgca
     6901 gggaaatcga attgatgcag tagcgctggt cggtcggcgt cgggtagccc tcgccctcga
     6961 agacgtggcc gaggtggctg tggcagctcg cgcacaggac ctcggtgcgc accgacccga
     7021 actggcggtc ctcgcgcagc acgacgctct cacccgcgag cggggagaag aacgaaggcc
     7081 agccgcaatg cgactcgaac ttcgtgtcgc tgcggaacag ctccgcgccg cacgcgcggc
     7141 actggtagac cccgaccgtt ttgctgtcgg tgtattcacc ggtgaacggg cgctcggttc
     7201 cggcctggcg cagcaccgcg aattcctcgg ggttgagctg cgcccgccat tcctgctcgg
     7261 acttgacgac cctgggggtg gcgccgacaa cgggtttcac gagatttctc ctccaagcgc
     7321 gcacgggttc agcccagcag catgctgaag atgaacacca gcgtgtccca cgcggcgacg
     7381 atgacgccga gcaggatcaa tgtcaccacg atgcccgcgg tgacgcggta gtggccgccc
     7441 aggcggttgg ccgcgtcggc gaagtcgccg acaccgccga tgtagccctc gacggtgtag
     7501 cccggacgca cccgctcgac ccggtcgagg tgttcagcga acgccctggc ctcggggtcg
     7561 tcgggatcca ggccgatcag gtcgtcggcg aagcggcccg gcggacccgg gcgcggctca
     7621 tcgtcggctg tccccgagga acctgtcgcg accatgcttc aacggtaacc cgaacgtggt
     7681 tacctgtcgc ccagcttgcg ctcctcgatc tccgcctgct cgctcttgag gtggacgaac
     7741 gaggtgaagc cccattcctc cagcctgccc agctgcgcgc cgaacttgcc gcgcctgcgg
     7801 atgggggaga ccggccggcc gtccgcgcgc agctcgcgag cggtgccggt gacccgcgcg
     7861 agcggaacgt cggcctcgta gagcaccgcg acggactctc cccgcgcctg cccttcgagc
     7921 aggtcgacga tgcgctcgaa gccgatggag aacccgcagg caggcacgtc gcggcccagg
     7981 gaacggccga tcagcttgtc gtagcgcccg ccgcccgcga cggagcccga ggagccgggg
     8041 tgcacgatct cgaagatctg accggtgtag tagcccatcc cgcgcaccag cgtcgggtcg
     8101 aattcccagg tcagcggcct ggtctcggcc agtgagcgca gcgcgtcggc ggtggcggac
     8161 aggtcggcga cgacctcgtc ggacaggccg ggcaccgacg cggtgagctg gtcggcgagc
     8221 ttggccgggt cgattccctg caggccggtg atgctcgcct gcaactggtc gatccggtcg
     8281 gtttcgaggc cgcggcccgc cagttcggcg cgcacgccgt cccagccgac cttgtcgagc
     8341 ttgtcgaggg tgatgaacag cccggtccac tccgactccg gcaggccgat gccctcggcc
     8401 agcgcggaca ggaaccggcg gtcggacacg cggaccgtgg tcccgtcgag gccgaccgcg
     8461 gccagtgcct cggtggtcgc ctcgatcagc tcgacctcgg ccagcaccga ttcctcgccc
     8521 agcatgtcga tgtcgcactg gtagaactgc cggtagcggc ccttctgcgg gcgctcggcg
     8581 cgccacaccg ggcccacctg gaacgagcgg aacggctgcg gcagggtcgc ctggttgttg
     8641 ccgtagaagc gggtcagcgg gacggtcagg tcgtagcgca ggccgaggtc gaccagttcg
     8701 ccgagcgtgg tgtcggcggc gacggtctcg tcgaggccgc ggcgcaggac ccggtagatc
     8761 agcttctcgt tctcgccgcc ctggccgccg gtgaggcgct cgatgttctc cagggcgggc
     8821 gtctcgatgc gctggtagcc gaaccggtgg tagacctcgg tgatctgggc caggacatgg
     8881 tcgcgcacgg cgacggtcgc gggcagcagg tcacgggtgc ccctggcggg gctgttgtcc
     8941 atcttcaccg gtacgggttc ctcgcagatc gcggtagcta tgacgagcag tacggtaccg
     9001 gggctgtgga tacttccgcg catgcattgc ctcgtcgccg tagtctgggg cggtggcaac
     9061 agaggctgtg gagatcaccg tcggcgaccg ggccgtgcga gtgtccaatc cggacaagcc
     9121 gtactttccc gagctggggc tgacgaagcg ccagatcgtc gagtacttcc tgtccgtggg
     9181 cgacggcatc ctcggcgcgc tgcgcgagcg cccgacgacg ctggaacgct ggcctggcgg
     9241 cgtcttcgag ggcgcgaagc tgtccaccag ggccgacaac cggggtgacg cgttctatca
     9301 gaagcgcatc ccgaagggcg cgcccgacta cgtcgagacc gcgcgcatcg ccttccccag
     9361 cggccgttcc gccgacgagg tctgcccgac ggagctggcg gtggtggcgt gggcggtgaa
     9421 cctgggcacc ctgacgttcc acccgtggcc ggtcagccgg gccgacgtcg accggcccga
     9481 ccagctgcgg atcgacctcg acccgcagcc gggcaccgac ttcaccgacg cggtcaaggt
     9541 cgcgttcacc gtgcgtgagc tgctggccga acacggcatc gaggcgttcc ccaagacctc
     9601 cggcggccgt ggcgtgcacc tctatgtccc gatcgagccg cgctggacct tcgtggaggt
     9661 ccggcgggcg ctgatcgcgt tcggccgctc ggtggcgcgg cggatgcccg acgaggtcac
     9721 ggtcaactgg tggaaggagg agcgcgggtc gcgcatcttc atcgattaca accagatggc
     9781 ccgcgaccgc acgatcgcct cggcgtactc gatccgcccg acgcagcgcg ccctggtctc
     9841 cgcgccggtc acctgggacg aactggggga cgtgcacccg gaggacttct cggtgctcac
     9901 gatgcccgcc cggttcgcgc aggtgggcga cctgcacgcg ccggtggcgg agaaggcgtt
     9961 ctcgctggag ccgctgatcg aactggcgga gcgggatgag cgcgacaacg gcttgggcga
    10021 cctgccgtat ccgccggact atccgaaaat gccgggggag cccaagcggg tccagccctc
    10081 gaaagcccgt gacgacacct gactcggccg ccctcggttt cgcggatgtc tcgttgatca
    10141 ctgccgcgcg tctcgcactg gccggcgacg acccgggact gtggaccgtc ctcgatctcc
    10201 gcgcgcggag ctactggtgg cgcgggcctg cggtgcccga cccgtcgccc gaggtggccg
    10261 tcgtgctcgc cgcctgtgac cggtccggcc gggtgcgtga gagcgcggtg accgatatcg
    10321 ccaggcgcgg taatcccgcg ctttggcccg tgctcgcctt gcgctgcgcc gactgggtgc
    10381 cggagattcg tgcccgcgcc cgggaggtgg cgctccgctg cctgggtgag ttgcccggag
    10441 ccgcgttcca ggcgttcgct ccgctcgcgc tcctcctggc gaagcgcgcc gagggacagt
    10501 ggctggccgg agtcgtggag gcgaacctgc gagaaggtcc tcccgaagtc ctcgcggtgg
    10561 cactggcctc gtcgaaccgc gtggtccgcc gcgccgccta tcggctcgcg atgggccgtc
    10621 ttccgctcga ccggctgctc agcgcggtgc gctccgacga tgacaccgtc attcggttgc
    10681 actgtgcgga ggcactgatc cgtatggggg atctcgacct cacgcggagc ttgttgtcca
    10741 gtgggacggc cgctgtgcgc gcggaagcgg tgcacgcgtt gggatcggcg ggtgagcgcg
    10801 gaccggc
//
