LOCUS       NZ_FNDV01000003        12785 bp    DNA     linear   CON 11-JAN-2024
DEFINITION  Actinokineospora alba strain CPCC 201030, whole genome shotgun
            sequence.
ACCESSION   NZ_FNDV01000003
VERSION     NZ_FNDV01000003.1
KEYWORDS    WGS; RefSeq.
SOURCE      Actinokineospora alba
  ORGANISM  Actinokineospora alba
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Actinokineospora.
REFERENCE   1
  AUTHORS   Varghese,N. and Submissions,S.
  TITLE     Direct Submission
  JOURNAL   Submitted (12-OCT-2016) DOE - JOINT GENOME INSTITUTE, LBNL, 2800
            Mitchell Drive, Walnut Creek, CA 94598, 94598, USA
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 01/11/2024 04:12:26
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,667
            CDSs (total)                      :: 6,588
            Genes (coding)                    :: 6,533
            CDSs (with protein)               :: 6,533
            Genes (RNA)                       :: 79
            rRNAs                             :: 4, 4, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 1, 1 (5S, 16S, 23S)
            partial rRNAs                     :: 3, 2 (16S, 23S)
            tRNAs                             :: 65
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 55
            CDSs (without protein)            :: 55
            Pseudo Genes (ambiguous residues) :: 0 of 55
            Pseudo Genes (frameshifted)       :: 14 of 55
            Pseudo Genes (incomplete)         :: 41 of 55
            Pseudo Genes (internal stop)      :: 4 of 55
            Pseudo Genes (multiple problems)  :: 4 of 55
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 14:41:36
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 909578
            Orig. end                         :: 922363
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            FNDV01000003.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..12785
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="hydrogen-cyanide"
                     /region_number="4"
                     /rules="(Fer2_4 and cds(Pyr_redox_2 and Fer2_BFD) and DAO)"
                     /tool="antismash"
     cand_cluster    1..12785
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(Fer2_4 and cds(Pyr_redox_2 and Fer2_BFD)
                     and DAO)"
                     /kind="single"
                     /product="hydrogen-cyanide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..12785
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:7785](-)"
                     /cutoff="5000"
                     /detection_rule="(Fer2_4 and cds(Pyr_redox_2 and Fer2_BFD)
                     and DAO)"
                     /neighbourhood="5000"
                     /product="hydrogen-cyanide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..7785)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="5000"
                     /detection_rule="(Fer2_4 and cds(Pyr_redox_2 and Fer2_BFD)
                     and DAO)"
                     /neighbourhood="5000"
                     /product="hydrogen-cyanide"
                     /protocluster_number="1"
     gene            729..1685
                     /locus_tag="BLR56_RS13660"
                     /old_locus_tag="SAMN05421871_103795"
     CDS             729..1685
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1014: LysR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015099801.1"
                     /locus_tag="BLR56_RS13660"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05421871_103795"
                     /product="LysR family transcriptional regulator"
                     /protein_id="WP_091368173.1"
                     /transl_table=11
                     /translation="MDLEFRHLRAICTIAETGSLSQAASALGVSQPSLTLLLQRVERSV
                     GGQLFLRSRTGTAPTALGERVLGRARVLLVELDAFSADLVRPNTQSVLRMGSAHMECVA
                     TLVSRLDETLPEAEIRLQVEPSSTMLAHSLTHGRLDAALIGMSDDKDVPLGAQVMYRTL
                     VPRVPVFVAVADTHPSARLPEIPLSDLAEDSWICPPGADDGSLATLRSACRGAGFVPRI
                     RFEVPSGGGRQLIRSGQAVQLVEPTSIGCPGLVVRPLAGEPLRMRLVLAWRRERLTESQ
                     INRIHEASAAAYTHHALESPVFRPWWLAHPEVHPRLS"
     gene            complement(1714..3084)
                     /locus_tag="BLR56_RS13665"
                     /old_locus_tag="SAMN05421871_103796"
     CDS             complement(1714..3084)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aldedh"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1017: aldehyde dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020668267.1"
                     /locus_tag="BLR56_RS13665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05421871_103796"
                     /product="aldehyde dehydrogenase family protein"
                     /protein_id="WP_091368170.1"
                     /sec_met_domain="Aldedh (E-value: 1.9e-128, bitscore:
                     424.6, seeds: 89, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTRVLSTSPQRPSDVVVDVPATEPGAVLAAAAQARVAQREWACAA
                     PGVRSAALAAIAQAVADNAAELAALAVREVGKPAAEAAGEVARTIALLRYYAQQAFDPI
                     GETYPTGGGLGFTARRPRGVAGLITPWNFPLAIPVWKSAPALAFGNAVLIKPSPDATAC
                     ALRLAELFTAHLPAGLFSVLPGAAETGAALVSCVDAVSFTGSGAVGRGVAVDAARRGIP
                     AQCEMGGLSATIVLPDADLDRAATDIAYAAMGFAGQKCTATKRVVVVGDSGPLGEALAS
                     KIGALGFGDPAEPKTAVGPVISEQARDRVADAVTHARAEGGQVVASGTRAGDEGWFVGP
                     TVIGGLAPEAALNREEVFGPITTLTSVPDLDAALSMANGTDYGLVTAVYTADLDVALAA
                     ADRCESGMVKVNAPTAGVDFHLPFGGEKDSGYGGREQGKAAAAFYTSSRTVQIGANR"
     gene            complement(3081..4082)
                     /locus_tag="BLR56_RS13670"
                     /old_locus_tag="SAMN05421871_103797"
     CDS             complement(3081..4082)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020646747.1"
                     /locus_tag="BLR56_RS13670"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05421871_103797"
                     /product="proline racemase family protein"
                     /protein_id="WP_091368167.1"
                     /transl_table=11
                     /translation="MRSARYFSAVDSHTEGMPTRVITGGVGVIPGATMAARREHFMANL
                     DHLRELLMNEPRGHSAMSGAILQPPTRPDADWGVLYIEVSGCLPMCGHGTIGVATVLVE
                     TGMVEVTEPVTTVRLDTPAGLVLAEVAVRDGRAEHVTVRNVPAYAHELDATIQVPGYGE
                     VRYDLAYGGNFYAIIPLETLGLPFDRAAKDPILAAGLSIMDAINAQRRPVHVADPSISG
                     CKHVQFTAPGQEGSHSRNAMAIHPGWFDRSPCGTGTCARMAQLHARGELKLGEDFVNES
                     FIGTRFTGRLLEEVPIGDRLGVLPTVTGRAWITGMGQYLLDPEDPFPRGFQL"
     gene            complement(4084..5004)
                     /locus_tag="BLR56_RS13675"
                     /old_locus_tag="SAMN05421871_103798"
     CDS             complement(4084..5004)
                     /EC_number="4.1.3.3"
                     /EC_number="4.2.1.41"
                     /EC_number="4.3.3.7"
                     /GO_process="GO:0009436 - glyoxylate catabolic process
                     [Evidence IEA]"
                     /GO_process="GO:0071704 - organic substance metabolic
                     process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009945560.1"
                     /locus_tag="BLR56_RS13675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05421871_103798"
                     /product="dihydrodipicolinate synthase family protein"
                     /protein_id="WP_091368165.1"
                     /transl_table=11
                     /translation="MTQERLDGVIVATALPYAEDPKAPAGLRPDLDRYAEHCQWLVANG
                     CRGVGPNGSLGEYSSLTDDERRQVARTAIEAVKGTGIVVVGVHGAGAHQARQWAELAAE
                     DGADGVLCLPPTMYRANHGEVIHHFTEVAKAGLPIMVYNNPIDTKVDLTPELVAEIAQI
                     DNVVAVKEFSGDVRRVLEIREAADIAVIAGADDVVLESLLMGATGWFAGFPNVFPAESA
                     RLYSLAMEGKLAEARALYEPLVAAFRWDSRTEFVQSIKFGMDVVGRFGGPCRPPRGPLA
                     DEQRAQLERDMRKAVDYLRANPVAA"
     gene            complement(5001..6350)
                     /locus_tag="BLR56_RS13680"
                     /old_locus_tag="SAMN05421871_103799"
     CDS             complement(5001..6350)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     hydrogen-cyanide: Pyr_redox_2"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     hydrogen-cyanide: Fer2_BFD"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1176: alkyl hydroperoxide reductase subunit"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013225096.1"
                     /locus_tag="BLR56_RS13680"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05421871_103799"
                     /product="FAD-dependent oxidoreductase"
                     /protein_id="WP_091368161.1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 7.2e-30, bitscore:
                     99.9, seeds: 64, tool: rule-based-clusters)"
                     /sec_met_domain="Fer2_BFD (E-value: 8.5e-08, bitscore:
                     28.3, seeds: 211, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTRRVVVVGAGPAGINAALAAADAGAEVTLVDSAPTVGGQFHRQP
                     AGAGPDKVPGGTRLVEHPNVRLLADTVVWAIEPLSDGHRVHVRTGQADGPGRRGETLTA
                     DALVLATGAYDRALPFPGWDLPGVVTAGAAQALAKGQGVAIGKRVVVAGTGPFLLPVAQ
                     SLTAVGAQVVEVLEANGGLRGWTPSALFAGRGKLAELAGYARLLATHRIPYRTRRTVIA
                     AHGEDRVTEVTTAALDREWGIRPGTERRVPVDAVCVGFGFTPQLELAVSARCRLIDGFV
                     EVTPSQETSVPGVFAAGELTGIGGADLAAAEGAIAGAAAAGRPIPEAALRKARRGRTFA
                     AGLADAYPVPPGWRTWPADDTLVCRCEEVTLAALRTAARERAALGVRSLKLTSRVGLGL
                     CQGRVCGRNAAELAAGFTGGHYDPADTARRPIAAPLRLGELAEDPDKEKT"
     gene            complement(6347..6613)
                     /locus_tag="BLR56_RS13685"
                     /old_locus_tag="SAMN05421871_103800"
     CDS             complement(6347..6613)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     hydrogen-cyanide: Fer2_4"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009945563.1"
                     /locus_tag="BLR56_RS13685"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05421871_103800"
                     /product="(2Fe-2S)-binding protein"
                     /protein_id="WP_091368158.1"
                     /sec_met_domain="Fer2_4 (E-value: 5.8e-22, bitscore: 73.3,
                     seeds: 114, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNVTVDGVAQPARPGQTVAALLIAAGQVSWRDTRTGGKPRGLFCG
                     IGVCFDCLVVVNGIPDVRACQRVVADGDEIRTQHGAELPEARS"
     gene            complement(6610..7785)
                     /locus_tag="BLR56_RS13690"
                     /old_locus_tag="SAMN05421871_103801"
     CDS             complement(6610..7785)
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     hydrogen-cyanide: DAO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1103: FAD dependent oxidoreductase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010697121.1"
                     /locus_tag="BLR56_RS13690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05421871_103801"
                     /product="FAD-binding oxidoreductase"
                     /protein_id="WP_228769564.1"
                     /sec_met_domain="DAO (E-value: 8.5e-64, bitscore: 212.0,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSVYPDVVVVGAGVIGAACAHALTVAGVRVTVLDRGAPASATTAS
                     GEGNVLVSDKAPGPELDLAVASRLRWPSLIESLREDLGAGAEIEWEAKGGLVVATTEAA
                     ARPLLDFAAAQRSVGVDAREIPAERARDFEPHLTRAVTAAVHYPQDAQLQPVLAACALL
                     AAVRERGGTVRSGVTVSGVDTDATGRVRAVRTSDGEVACGAVINACGPWSGAFSAAAGA
                     PIAILPRRGIVLVTAALPPTIRHKVYDADYVGAVASGDADLQTSSVVESTPAGPVLIGS
                     SRQRVGFTDHLEVKVLRELARKAVALFPILADVPVMRAYGGFRPYAPDHLPVIGPDPRV
                     PGLWHATGHEGAGIGLAAATGRLLAELLTGAEPHLDPTPFRVDRPALMEAA"
     gene            complement(7852..8466)
                     /locus_tag="BLR56_RS13695"
                     /old_locus_tag="SAMN05421871_103802"
     CDS             complement(7852..8466)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1148: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020668273.1"
                     /locus_tag="BLR56_RS13695"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05421871_103802"
                     /product="XRE family transcriptional regulator"
                     /protein_id="WP_091368155.1"
                     /transl_table=11
                     /translation="MGRESAGAVLGANIRALRTEMGLSLSELARRSEIAKGTLSQLENG
                     AGNPTIDTVFSLSNALRVPVSSLLTEQSKPGVVLVRSAGLDVLSSNAVDLRLLRRLDLV
                     ETVMEVYDQRVRPGEVQQSAGHPGYEHVVVTSGVLRVGPVAEPYVLEPGDYVCFPGHLP
                     HLYETVEGPVTSVLMLQYPVDAGTTPMAGSCAVSNAARPQG"
     misc_feature    complement(8564..8578)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 16.55"
                     /tool="antismash"
     gene            8687..9598
                     /locus_tag="BLR56_RS13700"
                     /old_locus_tag="SAMN05421871_103803"
     CDS             8687..9598
                     /EC_number="3.1.-.-"
                     /GO_function="GO:0016788 - hydrolase activity, acting on
                     ester bonds [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024863.4"
                     /locus_tag="BLR56_RS13700"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05421871_103803"
                     /product="SGNH/GDSL hydrolase family protein"
                     /protein_id="WP_166658089.1"
                     /transl_table=11
                     /translation="MTSRRTLAAVATATAVLATLAPNAAAAPTYREYVALGDSWTADVV
                     LIGPPTAEHAPIDCAQSAVNYPKLVATAIGVATFRDASCGSATTEHFANPQTGLPLGGT
                     NPPQFDRLTASTDLVTVGIGGNDAGLAGAAVGCLNLLPPLLPLPAPLGSYCKQSWVVGG
                     VDRMSENIRVAKQKVITSLRQIKHRSPKARVLVVNYLAGLPETGGCWPVVPVLTQDMEW
                     LSAKLRELNAALRDAAAVTGAELVDTYTPTIGRDVCQGPFTRYVEGLIPLSLNGVALAV
                     PFHPNSAGARAQAQTVLGKLRG"
     gene            9636..10253
                     /locus_tag="BLR56_RS13705"
                     /old_locus_tag="SAMN05421871_103804"
     CDS             9636..10253
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF025343.4"
                     /locus_tag="BLR56_RS13705"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05421871_103804"
                     /product="TetR family transcriptional regulator"
                     /protein_id="WP_091368150.1"
                     /transl_table=11
                     /translation="MTRMSADERRTALVEAAIRVMARDGVAKATTRAIVAEADMRLGFF
                     HYCFDSKEALLLQVLDAINQRNARVATEHVEAGKNLRDTVKASVDAYWAHVESNPGEHQ
                     VTYELTQYVLREPALATVARKQYENYALVATSVLETIAAATKMEWTVPLPILARFLHNT
                     LDGITLNWIVDRDTEKARAVLDQVTDYLVASARRPRAPRKTA"
     misc_feature    10407..10420
                     /note="TFBS match to PsrA, Oleic acid responsive regulator,
                     confidence: weak, score: 18.71"
                     /tool="antismash"
     misc_feature    12025..12040
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 17.73"
                     /tool="antismash"
     misc_feature    12421..12435
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.8"
                     /tool="antismash"
ORIGIN
        1 tagaaggtgt ccagcgcggc ctggatcgcc gtgcgcagcg tgggaccgta accgccgacg
       61 acatcggggt tgtaccactg gacgaaatac ccggcgcgca agtagaggac gagttggccg
      121 gtggcggtgg agttgtcgcc ggggtaagcg acggcgttgt cccgcagtcc gtacgcgacg
      181 ctcaccatct gcgcctcgcg gaaggctccg gtggccgtgc tcccggtgag cgtgaacagc
      241 gagttgacgc agtccagggt cgacgagcgg atgtgctgga ccagcgcggc cccggtgcgg
      301 ccggcgaact ccgccgggtc gcaggccgcg gcggactgtg tggccgccac cccactcgtt
      361 cgcggtgtgg tggccggaat cgggccgcgg tccttcagcg gcgtcgtcgt cctggactca
      421 cgggcggtgc cgtgggactg ggcgaccggc ggtggcgtgg tcgcggcgga cgggcgttca
      481 ggtgcggcga cggcggccgg ggccggtaag cccaaggtgg cggcgagcag ggtcagcagg
      541 accaacccgg gtcgcggacg aaatctcatc acggtgtctc cggtgcaggg ggatttgccg
      601 cgtcgggcgg catgcagggt agggcgcgcg agggagatcc tcctttggta tcaaggtcat
      661 cgcgcattga gggagagtca caccgagagg gatccactgg taatgatttg gctctatagt
      721 ctttgcttat ggacctggag ttccgacacc tgagggccat ttgcactatc gcggagacgg
      781 gcagcctctc gcaggccgcg tccgccctcg gggtgtccca gccgtcgctc accttgctgc
      841 tgcagcgcgt cgagcggtcg gtgggcgggc agctgttcct gcgcagccgc accggaaccg
      901 cgcccaccgc cctgggtgag cgggtgctgg gccgcgcgcg ggtgctgctg gtcgaactcg
      961 acgcgttcag cgccgacctg gtgcgcccga acacccaatc cgtgctgcgc atgggttcgg
     1021 cgcacatgga gtgcgtcgcg acgttggtct cccggctcga tgaaacgttg ccggaggccg
     1081 agatcaggct tcaggtggag ccgtcgagca cgatgctcgc ccactccctg acccatggcc
     1141 gactcgatgc tgccctgatc ggcatgtccg acgacaaaga cgtacccctt ggcgcgcagg
     1201 tgatgtaccg gaccctggtg ccgcgcgtac ccgtcttcgt cgcggtcgcg gacacgcatc
     1261 cctccgcccg cctgcccgag attcccttgt cggacttggc cgaagactcc tggatctgcc
     1321 cgcccggagc cgacgacggc tcgctggcga cgttgcgctc agcctgtcgc ggggcggggt
     1381 tcgtcccccg gatccgcttc gaggtcccca gcggcggcgg ccgccagctg atcaggtccg
     1441 gccaggcggt gcaactggtc gagccgacct cgatagggtg ccccggcttg gtcgtccgcc
     1501 cgctcgccgg cgaaccactg cggatgcgcc tggtgctggc gtggcggcgg gaaaggctta
     1561 cggagagcca gatcaaccgg atccacgaag cctccgccgc cgcctacacc caccatgcgc
     1621 tggagagccc ggtgttccgc ccgtggtggc tcgcgcaccc ggaagtccac cccaggctca
     1681 gctagcgacc cgctgaaagc cgctcggcgc gggtcagcgg ttcgctccga tctgcactgt
     1741 gcgggaagag gtgtagaagg ccgccgcggc cttgccctgt tcgcggccgc cgtagcccga
     1801 gtccttctca ccgccgaagg gcaggtggaa gtcgacgccc gcggtcgggg cgttcacctt
     1861 caccattccc gactcgcagc ggtccgccgc ggccagggcg acatcgaggt ccgcggtgta
     1921 gacggccgtg accagcccat agtcggtgcc gttcgccatg ctcagcgcgg catcgaggtc
     1981 cgggacggaa gtgagggtgg tgatcgggcc gaagacctct tcgcggttca gcgcggcttc
     2041 cggcgcgagt ccgccgatca ccgtcgggcc cacgaaccag ccctcgtcac ccgctcgcgt
     2101 gcctgacgcc accacctggc cgccctcagc gcgggcgtgt gtcaccgcgt ccgccacccg
     2161 gtcgcgggct tgttcgctga tcaccggtcc gaccgcggtc ttgggttcgg ccggatcacc
     2221 gaagccgagt gcgccgatct tgctcgcgag cgcctcgccg agcggcccgc tgtcgcccac
     2281 gacgaccacg cgcttcgtcg cggtgcactt ctgtccggcg aaccccattg ccgcgtacgc
     2341 gatgtcggtc gcggcgcggt cgaggtcggc gtcgggcagc acgatcgtcg ccgagagccc
     2401 acccatctcg cactgggccg ggataccgcg tcgcgcggcg tcgaccgcga cgccgcggcc
     2461 gaccgcaccg gacccggtga acgacacggc atccacacag gacaccagcg ccgcaccggt
     2521 ctccgccgcc ccgggcagca ccgagaacaa accggcgggg aggtgggcgg tgaagagttc
     2581 ggccaatcgc agggcgcacg cggtggcgtc cggcgacggc ttgatcagca cggcgttgcc
     2641 gaaagccagg gcaggggcgg acttccacac cgggatcgcc agcgggaagt tccacggggt
     2701 gatcaacccg gccaccccgc gcggcctgcg cgcggtgaac ccgagaccgc cgccggtcgg
     2761 gtaggtctcg ccgatcgggt cgaacgcctg ctgggcgtag taccgcagca gcgcgatggt
     2821 cctggccacc tcaccggccg cctccgcggc gggtttgccg acctcccgca ccgccagcgc
     2881 ggccaactcg gcggcgttgt cggcgaccgc ctgagcgatc gcggccagcg ccgccgaccg
     2941 gacgccgggg gcggcgcaag cccactcccg ttgcgcgaca cgggcttgcg ccgcggcggc
     3001 gagaacggcg ccgggctcgg tcgccggcac atcgacgacc acgtcggacg gtcgctgcgg
     3061 cgacgtggac aggactcggg tcacagctgg aaccccctgg ggaacgggtc ttcgggatcg
     3121 agcaggtact ggcccatgcc ggtgatccag gcgcggccgg tcaccgtggg caggacaccg
     3181 agccggtcgc cgatcgggac ctcctcgagc agcctgccgg tgaagcgggt gccgatgaag
     3241 gactcgttga cgaagtcctc ccccagcttc agctcacccc gggcgtgcag ctgggccatc
     3301 cgggcgcagg tcccggtgcc gcagggtgag cggtcgaacc agccggggtg aatggccatc
     3361 gcgttgcgcg agtggctgcc ttcctggccc ggcgcggtga actggacgtg cttgcacccg
     3421 ctgatgctcg gatcggcgac gtgcacaggc ctgcgctggg cgttgatggc gtccatgatg
     3481 gacagtccgg cggcgaggat cgggtccttg gcggcgcggt cgaacggcag tcccagcgtc
     3541 tccagcggga tgatcgcgta gaagttgccg ccgtaggcga ggtcgtagcg cacctcaccg
     3601 taaccgggga cctgaatggt ggcgtcgagt tcgtgggcgt acgcagggac gttgcgcacg
     3661 gtcacgtgct ccgcccgccc atcgcgcacg gcgacctccg cgagcaccag accggcgggg
     3721 gtgtcgagcc ggaccgtggt caccggctcg gtcacctcga ccatgccggt ctccaccagg
     3781 actgttgcca caccgatggt tccgtgcccg cacatcggca ggcagccgga cacctcgatg
     3841 tagagcacac cccagtcggc gtccggccgg gtcggcggct gcaggatcgc gccgctcatg
     3901 gcggagtgcc cgcgcggctc gttcatgagc agctcgcgca ggtggtccag gttcgccatg
     3961 aagtgctcgc ggcgggccgc catggtggct ccggggatga caccgacacc gccggtgatc
     4021 acccgggtcg gcatgccctc ggtgtgcgag tcgacggcgc tgaagtaccg ggcggacctc
     4081 atgtcacgcc gccacggggt tcgcgcggag gtagtcgacg gccttgcgca tgtcccgctc
     4141 caactgggcg cgctgctcgt cggccagcgg gccgcgcggc gggcggcacg gtccgccgaa
     4201 ccggccgacg acgtccatgc cgaacttgat cgactggacg aactcggtgc gcgagtccca
     4261 ccggaacgcg gccacgagcg gctcgtagag cgcccgcgcc tcggccagtt tgccttccat
     4321 ggcaagggag tagaggcggg cggactcggc ggggaagacg ttcgggaacc cggcgaacca
     4381 gccggtcgcg cccatcagca ggctctccag gacgacgtcg tcggccccgg cgatcaccgc
     4441 gatgtcggcg gcctcgcgga tctccagcac ccggcgcacg tcgccggaga actccttgac
     4501 cgcgaccacg ttgtcgatct gggcgatctc ggcgaccagc tcgggggtga ggtcgacctt
     4561 ggtgtcgatc gggttgttgt agaccatgat cggcagcccg gccttggcca cctccgtgaa
     4621 gtggtggatc acctcgccgt ggttggcccg gtacatggtg ggcggcaggc agagcacgcc
     4681 gtcggcgccg tcctcggcgg ccaactcggc ccattgccgc gcctggtggg cgcccgcgcc
     4741 gtgcacgccg accacgacga tgcccgtgcc cttgaccgcc tcgatcgcgg tgcgggcgac
     4801 ctgcctgcgc tcgtcgtcgg tcagcgagga gtactcgccg agggagccgt tcggcccgac
     4861 gccgcggcag ccgttggcca ccagccactg gcagtgctcg gcgtagcggt cgaggtccgg
     4921 gcgcaggccc gcgggcgcct tcgggtcttc ggcgtagggc agcgcggtgg cgacgatcac
     4981 gccgtcgagc cgttcctggg tcacgtcttc tccttatcgg ggtcctcggc gagttcgccg
     5041 aggcgcagtg gtgccgcgat cggccgtctg gccgtgtcgg cggggtcgta gtggccgcca
     5101 gtgaacccgg cggcgagttc ggcggcgttg cgtccgcaga cgcggccctg gcacaggcca
     5161 aggcccacgc ggctggtcag cttgagcgac cgcacaccga gcgcggcgcg ctcccgtgcg
     5221 gccgtgcgca gcgcggcgag ggtgacctcc tcgcaccggc agaccaaggt gtcgtcggcg
     5281 ggccaggtcc gccagcccgg agggaccggg taggcgtcgg ccagcccggc ggcgaacgtc
     5341 cggcctcggc gcgctttccg cagtgccgct tcgggaatcg gtctgcccgc cgccgccgcg
     5401 cccgcgatgg cgccttcggc cgcggcgagg tcggcgccgc cgatgccggt cagctcgccc
     5461 gcggcgaaca cgccgggaac ggaggtctcc tggctgggcg tcacctcgac gaacccgtcg
     5521 ataaggcggc agcgcgcgga gaccgcgagt tcgagttgcg gtgtgaagcc gaaccccacg
     5581 cagaccgcgt cgacgggaac gcggcgctcg gtccccggcc ggatccccca ctcgcggtcg
     5641 agggcggcgg tggtcacctc ggtgacccgg tcctcaccgt gggcggcgat caccgtgcgc
     5701 ctggtccggt agggaatgcg gtgcgtggcg agcagtcggg cgtatccggc cagttccgcg
     5761 agcttgccgc ggcccgcgaa gagagcggac ggcgtccagc cgcggaggcc gccgttcgcc
     5821 tccaggactt ccacgacttg ggcgccgaca gcggtcaggg attgcgcgac cggcagcagg
     5881 aaggggccgg tgcccgcgac gaccacccgc ttgccgatcg cgaccccttg tcccttcgcg
     5941 agggcttggg cggcgcccgc ggtgacgacg ccgggaaggt cccagccggg gaacggcagg
     6001 gcacggtcgt aggcgccggt ggccaggacg agggcgtcgg cggtcagggt ctcgccgcgg
     6061 cgtccgggtc cgtcggcttg gcccgtgcgc acgtggactc gatgtccgtc gctgagcggc
     6121 tcgatagccc agacgacggt gtcggcgagc aggcggacgt tcgggtgctc gacaagcctg
     6181 gtgccgccgg gaaccttgtc cggtcccgcg cccgcgggct ggcggtggaa ctgcccgccg
     6241 acagtgggcg cggagtccac cagggtgacc tcggcgcccg cgtcggcggc ggcgagcgcg
     6301 gcattgatgc ccgcgggccc ggcgccgacg accacgacac gtctggtcat gaccgtgcct
     6361 ccggcaactc ggcaccgtgc tgggtgcgga tctcatcccc gtcagcgacg acgcgctggc
     6421 aggcacggac gtcggggatg ccgttgacca cgaccaggca gtcgaagcac acaccgatgc
     6481 cgcagaacag gccgcgcggt ttgccaccgg ttctggtgtc ccgccaggac acctgccccg
     6541 cggcgatgag gagcgcggcc acggtctggc cggggcgggc gggctgggcc acgccgtcga
     6601 cggtgacgtt cacgccgcct ccatgagcgc cgggcggtcc actcggaacg gtgtcgggtc
     6661 gaggtgtggc tcggcaccgg tcagcagctc ggccagcaac cggcccgtcg cggcggccag
     6721 accgatgccc gcgccctcgt ggccggtggc gtgccagagg ccggggaccc gcgggtccgg
     6781 gccgatcacc gggaggtggt cgggagcgta gggacggaaa ccgccgtagg cgcgcatcac
     6841 cggcacgtcg gcgaggatcg ggaacagcgc caccgccttg cgggcgagtt cgcgcaggac
     6901 cttgacctcc aggtggtcgg tgaaacccac ccgctgcctg cttgagccga tcaggaccgg
     6961 gcccgcgggg gtcgactcga ccacgctgga ggtctgcagg tcggcgtcgc cgctggcgac
     7021 cgcgccgacg tagtcggcgt cgtacacctt gtgccggatg gtgggtggca gcgcggcggt
     7081 gaccaggact atcccgcgcc tgggcaggat ggcgatgggg gcgcccgcgg cggcggagaa
     7141 ggcaccggac cacgggccgc aggcgttgat gacggcaccg cacgcgacct cgccgtcgga
     7201 ggtgcgcacg gcgcggacgc ggccggtggc gtcggtgtcc actccggaca ccgtaacccc
     7261 cgaacgcacc gtgccgccgc gctcgcggac ggccgcgagc agcgcgcacg cggccaggac
     7321 cggttgcagt tgcgcgtcct gcggatagtg cacggcggcg gtgaccgcgc gggtcaggtg
     7381 gggttcgaag tcgcgggccc gctcggccgg tatctcccgg gcgtccaccc cgacggaccg
     7441 ctgggcggcg gcgaagtcca gcaggggccg ggcggcggcc tcggtggtgg cgacgacgag
     7501 accgcccttg gcctcccact cgatctccgc acccgcaccc agatcctcgc gcagcgactc
     7561 gatcagcgac ggccagcgca gtcgagacgc cacagcgagg tcgagttccg ggccaggtgc
     7621 cttgtccgac accaggacgt tgccctcacc ggacgcggtc gtggccgagg ccggtgcgcc
     7681 gcggtcgagc accgtcaccc ggacaccggc gacggtcagc gcgtgcgcgc aggcggcgcc
     7741 gatgacaccg gcgcccacca ccaccacgtc cgggtacacg ctcaccgcct ccaagcctcc
     7801 agcgttcatt aaagtgaaca ccggggacgt tagggctcaa agcgctgaac gtcaaccctg
     7861 aggtcgggcg gcgttcgaca ccgcgcagga accggccatc ggggtggtcc cggcgtccac
     7921 cgggtactgc agcatcagca cggaggtcac cggcccctcg accgtctcgt acaggtgcgg
     7981 gagatggccc gggaaacaca cgtagtcccc gggttcgagc acgtacggct cggcgaccgg
     8041 accgacccgg agcacgcctg aggtgaccac gacgtgctcg taaccggggt gtccggcgga
     8101 ctgctgcacc tcgccggggc gcacccgctg gtcgtagacc tccatcaccg tctcgaccag
     8161 gtccagcctg cgcagcagcc gcaggtcgac cgcgttgctg ctgagcacgt cgagcccggc
     8221 cgagcggacc agcacgaccc cgggcttgga ctgctcggtc agcagagacg agaccggaac
     8281 ccgcagcgcg ttcgaaagac tgaacaccgt gtcgatggtc gggttgcccg cgccgttctc
     8341 cagctgcgag agcgtgccct tcgcgatctc cgagcgccgc gccagttccg acagcgacag
     8401 gcccatctcc gtccgcaacg cgcggatgtt cgcgcccagc accgccccgg cactctctcg
     8461 ccccacaacg cctccctggt ccgccgcgga cggaacggtc cacctgcgcc cagccagatt
     8521 aaccggacgc cgtcgccaca cccgcacttc agagccgccg acgcaatatc tgaaacagcc
     8581 tcacattagt ccgaatgggt cattgtgcgt cggcgaacgc tcgatgacac ttgaccgacc
     8641 gtcgacttgg tcgcccgacc aaatccatga tccgatgagg tgccccttga cgagtcgccg
     8701 aacgctcgcc gccgtcgcca ccgccacggc cgtcctcgcc accctcgcgc cgaacgcggc
     8761 ggcggctccg acttaccggg aatacgtggc cctcggcgac tcgtggacgg cggacgtcgt
     8821 cctgatcgga ccgcccacgg ccgaacacgc ccccatcgac tgcgcccagt cggccgtgaa
     8881 ctacccgaaa ctcgtcgcga cggccatcgg ggtcgcgacc ttccgggacg cgagctgcgg
     8941 ctcggcgacc acggagcact tcgcgaaccc acagaccggc ctgccgctcg gcggcacgaa
     9001 cccgccccag ttcgaccggc tcaccgcgtc gacggacctg gtgacggtgg ggatcggcgg
     9061 caacgacgcg ggcctggcgg gggcggcggt tggctgtctc aatctgctgc caccactcct
     9121 gccgctgccc gcaccgctgg gcagctactg caagcagagc tgggtcgtcg gcggcgtcga
     9181 ccggatgtcg gagaacatcc gcgtcgcgaa gcagaaggtg atcacgtcgc tgcgccagat
     9241 caagcaccgc tcccccaagg cgcgtgtcct ggtggtcaac tacctggcgg gcctaccgga
     9301 gaccggcggc tgctggcccg tggtgccggt gctcacccag gacatggagt ggctctccgc
     9361 caagctccgc gaactgaacg ccgccctgcg cgacgcggcg gccgtaaccg gcgccgagct
     9421 ggtggacacc tacaccccga ccatcggccg ggacgtgtgc cagggcccgt tcacccggta
     9481 tgtggagggc ctgatcccgt tgtcgctcaa cggggtcgcg ctcgcggtgc cgttccaccc
     9541 gaactcggcg ggcgcacggg cgcaggcgca gacggtgctc gggaagctcc gcgggtaact
     9601 ttggcgggta ccgctggaga aggagcacac gcgccatgac tcggatgtcg gccgacgaac
     9661 gccgcacggc gctggtcgag gccgccatca gagtcatggc gcgcgacggg gtcgcgaagg
     9721 cgaccaccag ggcgatcgtc gccgaggccg acatgcggct cgggttcttc cactactgct
     9781 tcgactccaa ggaagcgctg ctcctgcagg tactcgacgc gatcaaccaa cgcaacgccc
     9841 gcgttgcgac cgagcacgtc gaggcgggaa aaaacctgcg cgacacagtc aaagcgagtg
     9901 tcgatgcgta ttgggcacac gtggagagca accccggcga acaccaggtc acctacgaac
     9961 tgacccagta cgtgctgcgc gaacccgcgc tggccacggt cgcccgcaag cagtacgaga
    10021 actacgcact ggtggcgact agcgtcctgg agacgatcgc cgccgcgaca aagatggagt
    10081 ggaccgtccc actccccata ctcgcccgct tcctgcacaa caccctcgac ggcatcaccc
    10141 tgaactggat cgtcgaccgc gacaccgaga aagcgcgcgc cgtgctcgac caggtcaccg
    10201 actacctggt cgcctcagcc cgccgcccac gagcaccccg caagaccgcc tgaaccagcc
    10261 cgaacacccc tccgccgaac aggccgagga caccccaacc gtccacagtg aatacggccc
    10321 atcccccagg cccgttgccc atgccgttgc cccatggccg ttgccccatg cccatgccca
    10381 tgccccacga acgcaagggg ccaacccaac ggcctgtttg ggtggagtgg tttctttggg
    10441 ggagaagaaa ggcccctaaa ctcgcgtggt cgtggggccg aaggcttccc acccgctttc
    10501 ccacgacagg ggcctttctt cgtaggggcc ccaaagaaac cactccaccc aaacaggcac
    10561 ccacttactc accagccagc aggcaacccc aaacaggcac ccaggcagca gctcagcgat
    10621 cagcatcccg aggcaaagaa agcatccgct ccccaatcac attgagctgc acctcagtag
    10681 tcccaccata aatcgtcatc gcccgacaag cgatcacctg atccatccac ttatcgctcg
    10741 gctccccctt caccgccacc accccagcaa ccccaagctc agcaaggcag aactcagcaa
    10801 tctgctgccc aaaccgcata ctcaggaact tccccacgct ggacgtagta ctcacatcag
    10861 caccggaaag ctgcttgagc acggttcgag ccccgagcag atcaagaacc tggttctcgc
    10921 agacgaactc cccaatccga tggatcgcgg tggcgtcgag gtcgcggcct gcggcgaacc
    10981 gcaggaggtc ggcgagcgtc gggtaggagg cgttgccccg gccgagggcg acccgttcgc
    11041 tggacagggt tgcgcgggcg accgtccagc cgtcgttgat ctccccgacc acgcagtcgt
    11101 ccggcacgaa cacgtcgtcg aggaacacct cgttgaacag ggccgagccg gtggcctcgc
    11161 gcagcgggcg cacggtcaca cccggggtgg tcatgtcgag gatgaagtac gtgatgccct
    11221 cgtgcttggg cgcggccggg tcggtgcggg cgatcagcat cgcccagtcg gagaactggg
    11281 ccaccgtggt ccagatcttc tggccgttga tcttccagcc gccgtcgacc cgctcggcct
    11341 tcgtcgtcag cgaggccagg tccgatcccg cgccgggctc ggagaacagc tggcaccaca
    11401 cgatctcgcc gcgcagggtg ggcacgacga cccgctgctt ctgctcttcg gtgccgtagg
    11461 cgacgatcgg tgggacggcc cagccgccca tgagcagctc aggcagctga atgcccgccc
    11521 gcttgatctc ctcgccgatg acgacctgtt ccagcgggcc ggcggcgcgg ccgtagggcc
    11581 ggggcaggtg cggctgcacc caaccgccgt cgcccagtgc gacgagttgg tcctcagcgc
    11641 tgagcacggc gacctcggcc agttcggcgc gcaccgattc gcggatcgcc tcgctgccct
    11701 cgggcaggtc gatggcgacg ggtcgggtga ctccgctcag cgcggaccgg gcgacgctgt
    11761 cggcccattc cgtgctgcgg ccgaggagtc cacgcaggga cagcgcgcgg cggtagtaca
    11821 ggtgggcgtc gtgctcccag gtgaagccga tgccgccgag gacctggatg cagtcggcgc
    11881 cgcagcgcac ggccgcgtcg ggggcgacca cggccgccac cgcggcggcg aaatcagcgg
    11941 cggcgggctc aacctgggag tccagcgccc gcgcggcgtc ccagacgacg gcccgcgcgc
    12001 gctccagctc gatgcccatg gccgcgcact tgtgtttcac gccttggaac tggccgatcg
    12061 gcctgccgaa ctggacccgc accttggcgt actcggcggc ggtcgagacg caccatgagg
    12121 cgatgcccac cgcttcggcg ccgagcagca ccgccgcgat cgagcggacg cgttcggcgg
    12181 tgaggccgtc gagcacccgc tcggcgggca ccgccacgcc tgtcgcctcg acgagtgcgc
    12241 agcggcggat cacgtccatg ctgtcctgct cacggacctt gaggtcggtc ttgtcgagca
    12301 cgacccaccg caccccagag ctgagccgca cgggcagcac gagcacgtcg gcgaccgctc
    12361 cgccgagcac tcctaccgtc gagcccgaca cgacgagacc gtcgccggtc tcgcggccat
    12421 cgaggggatc ggccaacccc acaccggcgg tgcgcgaccc gtccgccaag ccgggcagca
    12481 actcggcgcc gaccttggcg tccgcggcga ccatcaacgc cgaggcgagg acggtcggca
    12541 gcagcgggcc gggctgcgcg gcccggccga gcgcctccag ggcgaccgcc agctccagca
    12601 ggcccgcgcc ctgacccccg tgttcctcgg gaacgtgcag gccgagcagc ccttggcctg
    12661 ccagctcgcc ccagaacggg ggcaggctct cggctttggc gtccaccgcg gcacgcagca
    12721 cgtcggcggt gaggtggcgg tcggcgaatc cgcgcacgga atcggcgagc gccaagtgct
    12781 cctcg
//
