LOCUS       NZ_FMCU01000006        11935 bp    DNA     linear   CON 02-MAY-2024
DEFINITION  Micromonospora matsumotoense strain DSM 44100, whole genome shotgun
            sequence.
ACCESSION   NZ_FMCU01000006
VERSION     NZ_FMCU01000006.1
KEYWORDS    WGS; RefSeq.
SOURCE      Micromonospora matsumotoense
  ORGANISM  Micromonospora matsumotoense
            Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
            Micromonosporaceae; Micromonospora.
REFERENCE   1
  AUTHORS   Varghese,Neha. and Submissions,Spin.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-JUN-2016) DOE - JOINT GENOME INSTITUTE, 2800 Mitchell
            Drive, Walnut Creek, CA 94598, USA
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_900091525.1-RS_2024_05_02
            Annotation Date                   :: 05/02/2024 03:45:48
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,745
            CDSs (total)                      :: 6,674
            Genes (coding)                    :: 6,498
            CDSs (with protein)               :: 6,498
            Genes (RNA)                       :: 71
            rRNAs                             :: 5, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 5, 1, 1 (5S, 16S, 23S)
            partial rRNAs                     :: 2, 4 (16S, 23S)
            tRNAs                             :: 55
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 176
            CDSs (without protein)            :: 176
            Pseudo Genes (ambiguous residues) :: 0 of 176
            Pseudo Genes (frameshifted)       :: 35 of 176
            Pseudo Genes (incomplete)         :: 151 of 176
            Pseudo Genes (internal stop)      :: 7 of 176
            Pseudo Genes (multiple problems)  :: 16 of 176
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 09:03:39
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 41994
            Orig. end                         :: 53929
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            FMCU01000006.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..11935
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="1"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..11935
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..11935
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:6935](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..6935)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     gene            222..2663
                     /locus_tag="GA0070216_RS14145"
                     /old_locus_tag="GA0070216_10625"
     CDS             222..2663
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007455118.1"
                     /locus_tag="GA0070216_RS14145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GA0070216_10625"
                     /product="ricin-type beta-trefoil lectin domain protein"
                     /protein_id="WP_091245418.1"
                     /transl_table=11
                     /translation="MFSAQSHRRGGGPRRRPWRSAWRPRRLTASVLGVVVTAAAVLTGF
                     AAPAQAATAITINGGSGGRALDGIGAVSGGGGNSRLLIDYPEPQRSDILDYLFKPGYGA
                     AMQLMKVEIGGDTNSTSGAEPSHEHTRGSINCNRGYEWWLMEQARTRNPNIALAGLAWG
                     APGWIGNGNFWSTDSIDYLVAWLDCAGTHGLTINYLGGWNEKGYNTTWYKNLRSTLNSR
                     GYSSVKIVASDDFGWGAADDSLRDPAFASAVQVFGSHYVCGYRSAQTNCPSSTNAVSTG
                     KSLWASENGSDDYNAGAQALARGINRGYLDGKMTGYINWPAIAAITPNIPWATTGVAVA
                     QQPWSGAYSIGKNAWVMAQTTQFTAPGWRYLDASSGYLGGNRNNGSYVSLKSTNNSDYS
                     TVIETMDAGAAQTLDFTVTGGLSTGTVRVWSTNVRSNNTADHFVRGGDITPNGGRFSLT
                     VQPGYVYSITTTSGQGKGTAASPAQGNLKLPYSDNFDSYATGREARYLMDQQGSFEIAG
                     CAAGRTGQCVRQMSEQAPIYWTSGQAEPYTLLGDLTWRNYTVSSDVLLEKSGYAQLIGR
                     GNTYNHQGPQNMNGYYFRVTDGGAWSIRSNNTSGNWRTLASGNTSALGTGRWHTLALTL
                     NGSTLTAAIDGTTVGTANDSTWVAGQIGYGTGQGVTAQFDNLSVTAVGSPGTPTGEIRG
                     AGANRCLDVNGASQTDGAAVQIWDCTGGVNQRWSLTSTNQLTVYGNKCLDVPSAASGAR
                     ARIWSCTGGTNQQWRLNADGTIVGVGSGLCLDINGGGTANGSAVQLWTCNGGSNQQWVR
                     G"
     gene            complement(2748..3776)
                     /locus_tag="GA0070216_RS14150"
                     /old_locus_tag="GA0070216_10626"
     CDS             complement(2748..3776)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014443463.1"
                     /locus_tag="GA0070216_RS14150"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GA0070216_10626"
                     /product="glycoside hydrolase family 11 protein"
                     /protein_id="WP_091245421.1"
                     /transl_table=11
                     /translation="MSDTSTRPRRSGRLRLLLSAACAAALAVTGTFIASPNAYAENDRT
                     LTSNLTGTHNGYYFSFWKDSGNASITLRADGRYSSSWDRSTNNWVGGKGWATGTRRTVS
                     YSGTYNPGNNNTYLALYGWTRNPLIEYYVVENFGSYNPSSGATRLGTVTTDGGTYDILR
                     SLRTNAPSIDGIQTFYQYWSVRQQKRSSGTITTANHFDAWARAGLNLGTNHAYQIMATE
                     GYQSQGSSDITVREGGGNPTSGPTGNPTTPPAGGNCTAVLSAGEKWGDRFNLNVAVSGT
                     SNWVVSLGLNGGQSIQNSWNASVSGTTGTVTARPNGNGNNFGITIMANNNWTWPTVTCR
                     TA"
     misc_feature    3999..4013
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 16.51"
                     /tool="antismash"
     gene            complement(4306..4989)
                     /locus_tag="GA0070216_RS14155"
                     /old_locus_tag="GA0070216_10627"
     CDS             complement(4306..4989)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF039872.3"
                     /locus_tag="GA0070216_RS14155"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GA0070216_10627"
                     /product="DUF5825 family protein"
                     /protein_id="WP_091245425.1"
                     /transl_table=11
                     /translation="MLTTDFDSRPILVGLARDHDPAVLSIPGMTIGPAELREPAADAVA
                     RWRAEGVRRVDLPGAVDLTVTGADETAVDTVRRLVLVRELTSHGIAVDWRLRLPGAEAD
                     EWLPYSHLRAPVELLPPPGGAGDPVPQLAAWGKAFYFDKCTYRRGPGFVQVRDRRSGRL
                     NLLTIDDPAYLAVLDQLLDGAAITDVDLDIARDFGAEGLVTKIGDLLVWLPHRLRRWPL
                     PSMVI"
     gene            complement(5001..6935)
                     /locus_tag="GA0070216_RS14160"
                     /old_locus_tag="GA0070216_10628"
     CDS             complement(5001..6935)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: TIGR03975"
                     /gene_functions="other (smcogs) SMCOG1277: Radical SAM
                     domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007076102.1"
                     /locus_tag="GA0070216_RS14160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GA0070216_10628"
                     /product="RiPP maturation radical SAM C-methyltransferase"
                     /protein_id="WP_281190428.1"
                     /sec_met_domain="TIGR03975 (E-value: 1.8e-180, bitscore:
                     595.5, seeds: 14, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLVNTPWTSIDVPSLAIGILTNSVRQKLPDAEVEAVHANLDFVDW
                     VVDRTEFGLSDYYYYSLFTYFAGCGDWVFSSALYDDPEWRVKEFTDRVRTQMTERELAL
                     NIELHRLAPEFVAELADRIVAQAPDVVGFTSTFQQNAAALATARAIKKRAPGIRTVMGG
                     ANCDGEQGAAIHRNFSFVDYVVRGEGETAFPRLLAAIDPARSAVGVAEPAGGLADIEGL
                     CWAGPDGRSVANPMSTTPLPPAEIVSPDYAGYFERLAASRARNWVEPRLVVEGARGCWW
                     GEKHHCTFCGLNGSFMQFRSKHPGKFYDEIIELVERHQVLDMFVVDNILDMSYVTSLLP
                     RLTESDYDLRLQYEIKSNMKGPQVQALADAGLVSVQPGIESLNSRVLKLMDKGVSGCLN
                     VRMLRDAETSGITIAWNYLYGFPGETEADYLPVIAQMPALHHLCPADGNTRIAIERFSP
                     FFVNPALGFTDLRPAAQYRLIYDLPESELMDLAYLFDVPPQGIGGETADRLGRAVTEWQ
                     HEYARSRLTHHDLGDEIVLVSRRKHFDWHILRLTDPTELAVFRQLDQPHSVAALARRLS
                     VDESTLVSLLQRWRELGLVYEDAGQFIQIAPQAMNQDLLRIDHLHLEREAAATRAAAEA
                     GEPAVLTAV"
     gene            complement(7188..9005)
                     /locus_tag="GA0070216_RS14165"
                     /old_locus_tag="GA0070216_10630"
     CDS             complement(7188..9005)
                     /GO_function="GO:0008236 - serine-type peptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S9"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012546.4"
                     /locus_tag="GA0070216_RS14165"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GA0070216_10630"
                     /product="prolyl oligopeptidase family serine peptidase"
                     /protein_id="WP_091245431.1"
                     /sec_met_domain="Peptidase_S9 (E-value: 3.8e-34, bitscore:
                     112.3, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSGGHRLFYPALPVVAEHAPHRAVYVGDAEGRCEILAWDRSAGTA
                     RQVTDRPAGTIRAAIDPTGTTIWWFDDDLGGVGTWRTCGFDRPDRSVAALPSVPPARHA
                     GIAMATDGTTAIGLSDDGGMTLFLRSGDGRVSERAHVTGYAYLVDLDPAGQLAAIGADA
                     ATDAAVTVFTTDGGRVADIAGRADGRVWALGFAPGSGPARLLLVIEDRGGYLPATWTAD
                     DGLVRHDWCRFDTEITAGWFPDGQRLLVRQDRHARSLLHEVDLAGRTRTVVDTPTGSIL
                     DAAVWPDGDIAYVWTDSVTPPQLRSVRGLELPEHPGGQPDAGGPDAVTAPTDYRREEIR
                     VPGPGGPIPALVAVPTDRDGPRPAVFLVHGGPFQHARDAYDPLVEVLVSTGCVVVRVNY
                     RGSSGYGAAWRNDFSAGVGLTQLEDLAAVRAHLVAEGVVEDRRTALWGTSWGGYLTLLA
                     LGRQPELWRLGIAISPVADYVAAFEAATPAVRALDVLLFGGTPGEVPQRYARSSPITYV
                     DQVRAPVLLAVSTGDVRCPPAPVEHYARLLAGRRVPHQVVRRRAGHEDFDAQSHLALMQ
                     TVLLFMQRHFDGVRDEGTPVALAMARPVG"
     gene            complement(9002..10300)
                     /locus_tag="GA0070216_RS14170"
                     /old_locus_tag="GA0070216_10631"
     CDS             complement(9002..10300)
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1020: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF017760.4"
                     /locus_tag="GA0070216_RS14170"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GA0070216_10631"
                     /product="MFS transporter"
                     /protein_id="WP_091245434.1"
                     /transl_table=11
                     /translation="MTAAPSQDIKPEESTHRGRDFRRYWIAGAIDQLGSQASGIVLPLV
                     TLAVTGSPAAAGLVGALALAGRLVAAPVAGVLADRLPRKRMMISSLLVAAGAMTAIFVG
                     LLADVATLGLLAAAAFVEGIAQSGYEAAGSGAIRRLLPADDQKALSRLEARNHAARLTG
                     PLLGGVLYQLARWLPFLADVLSYLLAAALVATIRTDLTPERAERTSFRTDLKVGLRFVW
                     RQPFLRFVTIWAAGINFTFGALVYYAILTAGRQGVPAASIGLILTIASVGGLSGALAAP
                     MIFSRVRPTTVIVFASWAMVGLVVAMSQARQTWSYGLLFGLVFLLSPLLGVIFQSRVIA
                     LTPDELQGRVATVMGTVGEVLQTPAPLLAGVLVAWYSPGTVALVFAAVLALLATYTTAS
                     LRQLRAGAGATAGTDPDPAATAEATADPEEARR"
     misc_feature    complement(10323..10336)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 14.43"
                     /tool="antismash"
     misc_feature    10598..10607
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 14.29"
                     /tool="antismash"
     misc_feature    11665..11680
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: medium, score: 21.56"
                     /tool="antismash"
     misc_feature    11666..11680
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 20.12"
                     /tool="antismash"
ORIGIN
        1 ggcaaccatt catctgatct ctttgggatt cccgcggcga ttgatcagag aaagggcggg
       61 ataaatccct ccgaacaggg gcgttgaccg gcgaccgctg cggtgcctaa catacgacgt
      121 cctatcattg atagtcgccg atttccatcc tgcgcgggtg cgacagtccg acgtgtgccg
      181 taccgcttcg aggtcggaga ccggctgggg aggcgagtca gatgttcagt gcacagagtc
      241 atcggcgcgg cggcggccca cgtcgccgac cgtggcgcag cgcgtggcgt ccgcgtcggt
      301 tgaccgcatc ggtgctggga gtggtggtga cggcggcggc ggtgctgacc gggttcgccg
      361 caccggccca ggcggcgacc gccatcacga tcaacggcgg gtccggtggc cgggcgctgg
      421 acgggatcgg tgcggtcagc ggcggcggtg gcaacagcag gctgctgatc gactatccgg
      481 agccgcagcg cagcgacatc ctggactacc tgttcaagcc gggctacggc gcggccatgc
      541 agctgatgaa ggtggagatc ggcggcgaca ccaactccac ctccggcgcg gagcccagcc
      601 acgaacacac ccggggcagc atcaactgca accggggcta cgagtggtgg ctgatggagc
      661 aggcccgtac ccgcaacccc aacatcgccc tggcgggtct ggcctgggga gcacccggct
      721 ggatcggcaa cggcaacttc tggtccaccg actcgatcga ctacctggtg gcctggctgg
      781 actgcgcggg cacccacggg ttgaccatca actacctcgg cgggtggaac gagaagggct
      841 acaacaccac ctggtacaag aacctccgct cgaccctcaa ctcccgcggc tacagcagcg
      901 tgaagatcgt cgcctcggac gacttcggtt ggggcgcggc cgacgactcg ctgcgggacc
      961 cggccttcgc cagcgccgtc caggtcttcg gcagccacta cgtctgcggc taccgcagcg
     1021 cccagaccaa ctgccccagc tccaccaacg cggtgtccac cggcaagtcc ctgtgggcca
     1081 gcgagaacgg ctccgacgac tacaacgccg gcgcgcaggc gctcgcccgg ggcatcaacc
     1141 ggggctacct cgacggcaag atgaccggct acatcaactg gcccgccatc gccgccatca
     1201 cccccaacat cccctgggcg accacgggtg tggcggtggc ccagcagccg tggtccggcg
     1261 cctactcgat cggcaagaac gcctgggtga tggcgcagac cacccagttc accgccccgg
     1321 ggtggcgcta cctcgacgcg tcgagcggct atctcggcgg caaccgcaac aacggcagct
     1381 acgtctcgct gaagtccacc aacaacagcg actacagcac cgtcatcgag acgatggacg
     1441 ccggcgccgc gcagaccctc gacttcaccg tcaccggcgg cctgtccacc ggcacggtac
     1501 gggtctggtc gacgaacgtg cggtcgaaca acaccgccga ccacttcgtc cggggcggtg
     1561 acatcacccc gaacgggggg cgcttctcgc tcaccgtcca gcccggttac gtctacagca
     1621 tcaccaccac cagcgggcag ggcaagggca cggcggccag cccggcgcag ggcaacctga
     1681 agctgccgta cagcgacaac ttcgactcgt acgccaccgg ccgcgaggcg cgctacctga
     1741 tggaccagca gggctcgttc gagatcgccg ggtgcgcggc gggtcgcacc gggcagtgcg
     1801 tacgccagat gtcggagcag gcgccgatct actggacctc cggccaggcc gagccgtaca
     1861 ccctgctggg cgacctgacc tggcgcaact acacggtctc ctcggacgtg ctgctggaga
     1921 agtccggcta cgcgcagctc atcgggcgcg gcaacaccta caaccaccag ggcccgcaga
     1981 acatgaacgg gtactacttc cgggtcaccg acggtggcgc ctggtccatc cggagcaaca
     2041 acaccagcgg caactggcgc accctggcca gcggcaacac ctccgccctg ggcaccgggc
     2101 ggtggcacac cctggcgttg acgctcaacg ggagcaccct caccgccgcg atcgacggca
     2161 ccaccgtcgg cacggccaac gactccacct gggtcgccgg ccagatcggg tacggcaccg
     2221 ggcagggcgt caccgcccag ttcgacaacc tctcggtgac cgccgtcggc agccccggca
     2281 ccccgacggg tgagatccgg ggagcgggcg ccaaccggtg cctggacgtc aacggggcca
     2341 gccagaccga cggcgcggcg gtgcagatct gggactgcac cggcggcgtc aaccagcggt
     2401 ggtcgctgac ctcgaccaac cagctcaccg tctacggcaa caagtgcctc gacgtgccga
     2461 gcgccgcgtc gggcgcccgg gcccggatct ggagctgcac cggcggcacc aaccagcagt
     2521 ggcggctcaa cgccgacggc acgatcgtcg gggtgggctc ggggctctgc ctggacatca
     2581 acggcggggg caccgccaac ggctccgccg tccagctctg gacctgcaac ggtggcagca
     2641 accagcagtg ggtacgcggc tgaccacggg cgacaacggt acggcgggcg gtcccggtgt
     2701 catcgggacc gcccgccgct gcggtgctgt tcaggaaccg gtcggggtca ggccgttcgg
     2761 caggtgaccg tcggccaggt ccagttgttg ttggccatga tcgtgatgcc gaagttgttg
     2821 ccgttgccgt tcggcctggc ggtgacggtg cctgtggtgc cgctgaccga ggcgttccag
     2881 ctgttctgga tgctctggcc gccgttgagc ccgaggctga ccacccagtt gctggtgccg
     2941 ctgaccgcga cgttcaggtt gaaccggtcg ccccacttct cgccggccga cagcaccgcg
     3001 gtgcagttgc cgccggcggg cggggtggtc gggttgccgg tcggtccgct ggtggggttg
     3061 ccgccaccct cgcggacggt gatgtcggag ctgccctggc tctggtaacc ctcggtggcc
     3121 atgatctggt aggcgtggtt ggtgccgagg ttcaggccgg cgcgggccca ggcgtcgaag
     3181 tggttggcgg tggtgatggt gccgctgctg cgcttctgct ggcggacgct ccagtactgg
     3241 tagaacgtct ggatgccgtc gatcgacggg gcgttggtcc gcaggctgcg caggatgtcg
     3301 taggtgccgc cgtcggtggt gaccgtgccc agccgggtgg cgccgctgct cgggttgtag
     3361 ctgccgaagt tctccaccac gtagtactcg atgagcgggt tgcgcgtcca gccgtacagg
     3421 gcgaggtagg tgttgttgtt gccggggttg taggtgcccg agtagctgac cgtccggcgg
     3481 gtgccggtgg cccagccctt gccgccgacc cagttgttgg tgctccggtc ccagctgctg
     3541 ctgtaccggc cgtcggcccg cagcgtgatg ctggcgttgc cactgtcctt ccagaacgag
     3601 aagtagtagc cgttgtgcgt gccggtgagg ttcgaggtga gggtccggtc gttctcggcg
     3661 tacgcgttgg gcgaggcgat gaacgtgccg gtgacggcga gcgccgcggc gcacgcggcg
     3721 ctgagcagca gccgcaggcg accgctcctt cgcggtcggg tcgaggtgtc gctcatgtac
     3781 gtgttcctcc tcgtgacagc tggcggacgc cagcgacgcg gtacgacccg gtggactgtc
     3841 cgtagccagg tacggcagcc ggccatgcgg tgggtgtcac cacgcggtgg tgggccggtc
     3901 gtccagcaga accgggggga cgggtcgcgg tgggtggtgt cgacggcatc gaatgccgtc
     3961 gatggcgacg gtagggtgtc gatgctccac ctgtcaacaa gtttcggaaa tcttcccgaa
     4021 acatcgtccc ggccagtggt ggacttcggg aggatttcga ctggctgacg ttcgctgtct
     4081 aaagagctgg cctgcgctag gggctggttg acccgacagg aagggtgctt cttctctgta
     4141 tacccgaaac tttcgagcac cgccagtcac cccctgccgg cgggtggggc aggggcatgc
     4201 gaaccgcccg cccacccggc ctggatctcc aggcggggcg ggcgggcggt cgcggagcgt
     4261 ggaccggggc ggcggaccgg ccgggcggcg gacgatccgg ggcgctcaga tcaccatcga
     4321 cggcaggggc cagcggcgga gccggtgtgg cagccacacc agcaggtcgc cgatcttcgt
     4381 gaccaggccc tccgcaccga agtcacgggc gatgtcgagg tcgacgtcgg tgatggcggc
     4441 gccgtccaac agctggtcga gcaccgcgag gtaggccggg tcgtcgatgg tcaacagatt
     4501 cagccggccg gaccggcggt cgcgcacctg cacgaatccg ggaccccggc gatacgtgca
     4561 cttgtcgaag tagaacgcct tgccccaggc ggcgagttgc gggacggggt cgcccgcacc
     4621 acccggcggt gggagcagct cgaccggcgc ccgcaggtgg ctgtagggga gccactcgtc
     4681 ggcctcggca cccggcagcc gcagccgcca gtcgacggcg atgccgtggc tggtcaactc
     4741 gcggacgagc accaggcggc ggaccgtgtc gacggccgtc tcgtcggccc cggtgaccgt
     4801 gaggtcgacg gctccgggga ggtcgacccg gcggaccccc tcggcacgcc agcgggcgac
     4861 cgcgtcggcg gccggctcgc gcagctcggc cgggccgatg gtcatcccgg ggatcgacag
     4921 gacggccggg tcgtggtcgc gggcgagacc gaccaggatg ggccgggagt cgaagtcggt
     4981 ggtgagcacg tgcggtcccc tcagactgcg gtgagcacgg ccggctcacc ggcttcggcg
     5041 gcggccctgg tggcggcggc ttcgcgttcc aggtgcaggt ggtcgatgcg cagcagatcc
     5101 tggttcatgg cctgcggcgc gatctggatg aactgccccg cgtcctcgta gacgagcccg
     5161 agttcgcgcc agcgctgcaa cagcgacacc agggtcgact cgtcgacgga cagtcgccgg
     5221 gccagggcgg cgacgctgtg cggctggtcg agctgccgga agacggccag ctcggtgggg
     5281 tcggtcagcc gcaggatgtg ccagtcgaag tgcttgcgcc ggctgaccag cacgatttcg
     5341 tcgccgaggt cgtggtgggt gagccggctg cgggcgtact cgtgctgcca ctcggtgacc
     5401 gcccggccca gccggtcggc cgtctcgccg ccgatgccct ggggcgggac gtcgaacagg
     5461 tacgccagat ccatcagttc cgactcgggc aggtcgtaga tcagccggta ctgggctgcc
     5521 ggccgcaggt cggtgaagcc gagcgcgggg ttgacgaaga aggggctgaa ccgttcgatg
     5581 gcgatgcggg tgttgccgtc ggccgggcac aggtggtgca gtgccggcat ctgcgcgatg
     5641 accgggaggt agtcggcctc ggtctcaccc gggaacccgt acaggtagtt ccaggcgatg
     5701 gtgatcccgc tggtctcggc gtcgcgcagc atccggacgt tgaggcagcc gctgaccccc
     5761 ttgtccatca gcttgagcac ccggctgttg aggctctcga tgccgggctg cacgctgacc
     5821 aggccggcgt cggccagggc ctgcacctgc gggcccttca tgttcgactt gatctcgtac
     5881 tgcaaccgca ggtcgtagtc cgattcggtg agccggggca gcagcgaggt cacgtagctc
     5941 atgtcgagga tgttgtccac gacgaacatg tccaggacct ggtgccgctc gaccaactcg
     6001 atgatctcgt cgtagaactt gcccggatgc ttgctgcgga actgcatgaa cgacccgttg
     6061 aggccgcaga acgtgcagtg gtgcttctcg ccccaccagc agccccgggc gccctcgacg
     6121 accagccggg gctcgaccca gttccgggcc cgggacgcgg ccagccgttc gaagtagccc
     6181 gcgtagtccg gggagacgat ctcggccggc ggcaggggcg tggtgctcat cgggttcgcc
     6241 acggaacggc cgtccgggcc ggcccagcac agcccctcga tgtcggcgag cccgcccgcc
     6301 ggctccgcga cgccgaccgc cgaccgggcc gggtcgatcg cggcgagcag tcggggaaac
     6361 gcggtctcgc cctcgccccg gaccacgtag tcgacgaacg agaagttgcg gtggatcgcc
     6421 gcgccctgct caccgtcgca gttggccccg cccatcaccg tacggatgcc gggtgcccgc
     6481 ttcttgatcg ccctggcggt ggcgagggcg gcggcgttct gctggaacgt ggaggtgaag
     6541 ccgaccacgt ccggggcctg ggcgacgatc cggtcggcca gttcggcgac gaactccggg
     6601 gccaaccggt gcagctcgat gttgagcgcg agttcccgtt cggtcatctg ggtccggacc
     6661 cggtcggtga actccttcac ccgccattcg ggatcgtcgt acagggccga ggagaagacc
     6721 cagtcaccgc agcccgcgaa ataggtgaag agcgaatagt agtagtagtc gctcaatccg
     6781 aactcggtcc ggtcgaccac ccagtcgaca aagtcgagat tcgcgtggac ggcctccacc
     6841 tcggcatccg gcagcttctg ccggacactg ttggtgagga ttccaatcgc caacgaaggg
     6901 acgtcgatgg aagtccatgg cgtattgacc agcatgaccc gcacgtaacc tctcctctct
     6961 cgtgagctgt tcggaccgga cgacggatac ggggtggggc cacctgcccg ggcgggtggc
     7021 cacaccccgt acggccgcta gaagctgacc ttgaccgtga ccgtgaccgt gacgttcgag
     7081 gcccgaagct ggtcgcggtt gccgttgatc gggtcgttct cgacaacgtt cttgcgcatg
     7141 tcgttcacct cctttccgtt atcgggggac cgggtcacgt gccggggtca gcccaccgga
     7201 cgcgccatcg cgagcgcgac cggcgtgcct tcgtcccgca cgccgtcgaa gtgccgctgc
     7261 atgaacagca gcacggtctg catcagagcc aggtggctct gcgcgtcgaa gtcctcgtgc
     7321 ccggcccgcc ggcggaccac ctggtgcgga acccggcgac cggccagcag ccgcgcgtag
     7381 tgctccaccg gtgccggcgg gcagcgcacg tcaccggtgg agacggccag cagcaccggg
     7441 gcccggacct ggtcgacgta ggtgatcggc gaggaccggg cgtagcgctg cggcacctcg
     7501 ccgggggtgc cgccgaacag cagcacgtcc agcgcccgta ccgccggggt ggccgcctcg
     7561 aaggcggcga cgtagtcggc gacgggactg atcgcgatcc cgagccgcca cagctccggt
     7621 tgccggccga gcgcgagcag ggtcaggtag ccgccccacg acgtgcccca cagggcggtg
     7681 cgccggtcct cgacgacgcc ctcggcgacg aggtgggccc ggaccgcggc gaggtcctcc
     7741 aactgggtga ggccgacccc ggcggagaag tcgttgcgcc aggccgcgcc gtacccgctg
     7801 gagccccggt agttgacccg gaccaccacg cagccggtgc tgaccaggac ctcgaccagc
     7861 gggtcgtagg cgtcgcgggc gtgctggaag ggtccgccgt ggaccaggaa gacggccggc
     7921 ctcggcccgt cccggtcggt cggcacggcg accagggcgg ggatcggacc accgggcccc
     7981 ggcacccgga tctcctcgcg gcggtagtcc gtgggtgccg tgacggcgtc cggcccgccc
     8041 gcgtcgggct gaccgccggg gtgctccggc agctccagcc cgcgcacgga acgcagttgg
     8101 ggcggggtca ccgagtcggt ccacacgtac gcgatgtcac cgtccggcca gaccgcggcg
     8161 tccaggatgc tgcccgtcgg ggtgtcgacg accgtccggg tccgcccggc gaggtccacc
     8221 tcgtgcagca ggctgcgggc gtgccggtcc tgccggacga ggaggcgctg cccgtccggg
     8281 aaccagccgg cggtgatctc ggtgtcgaag cggcaccagt cgtgccggac caggccgtcg
     8341 tccgcggtcc aggtcgccgg gaggtagccg ccccggtcct cgatcaccag cagcagccgc
     8401 gccgggccgg acccgggggc gaaaccgagg gcccacaccc gcccgtcggc ccggccggcg
     8461 atgtcggcca cccggccgcc gtcggtggtg aacaccgtga ctgccgcgtc ggtggcggcg
     8521 tcggcgccga tcgccgccag ctgcccggcc ggatcgaggt cgaccaggta cgcgtagccg
     8581 gtgacgtggg cccgttcgct cacccggccg tcgccggagc gcaggaacag ggtcatcccg
     8641 ccgtcgtcgg acagcccgat cgcggtggtg ccgtcggtgg ccatggcgat gccggcgtgc
     8701 cgggccggcg gcaccgacgg cagcgccgcg acggagcggt cgggccggtc gaagccgcac
     8761 gtccgccagg tgccgacgcc gccgagatcg tcgtcgaacc accagatggt ggtccccgtc
     8821 gggtcgatcg ccgcccggat cgtgccggcc gggcggtcgg tcacctgccg ggcggtgccg
     8881 gcggagcggt cccaggccag gatctcgcag cgcccctcgg cgtcgccgac gtagacggcc
     8941 cggtgcggcg cgtgttcggc gacgaccggc agcgccggat agaagagccg gtgaccgcca
     9001 ctcatctgcg ggcctcctcg ggatcggcgg tggcctcggc ggtggcggcc gggtcggggt
     9061 cggtcccggc cgtcgcgccc gcaccggcgc ggagttggcg caggctggcg gtggtgtacg
     9121 tcgccagcag cgccagcacg gcggcgaaga ccagagcgac ggtgccgggg ctgtaccagg
     9181 ccaccaggac cccggccagc agcggcgccg gtgtctgcag cacctcgccg acggtgccca
     9241 tcacggtcgc cacccgaccc tggagctcgt cgggcgtcag cgcgatcacg cgggactgga
     9301 agatgacccc gagcagcggg ctgagcagga agaccagccc gaacagcagc ccgtagctcc
     9361 aggtctgccg ggcctgtgac atcgcgacga cgaggcccac catggcccac gaggcgaaca
     9421 cgatgacggt tgtcggccgt acccggctga agatcatcgg agcggccagt gcgccgctca
     9481 ggccgcccac gctggcgatg gtgaggatca ggccgatcga cgccgcgggg acaccctgcc
     9541 ggccggcggt caggatggcg tagtagacga gggcgccgaa ggtgaagttg atgccggccg
     9601 cccagatcgt gacgaaccgc aggaacggct gccgccacac gaagcgcagc ccgaccttca
     9661 ggtcggtgcg gaacgaggtg cgctctgcgc gttcgggcgt cagatcggtc cggatggtgg
     9721 cgacgagagc cgccgcgagc aggtaggaca gcacgtccgc caggaacggc agccagcggg
     9781 cgagctggta gagcacgccg ccgagcagcg ggccggtgag tcgggcggcg tggttgcggg
     9841 cctccagccg ggacagcgcc ttctggtcgt cggccggcag caggcggcgg atggcgccgg
     9901 agccggccgc ctcgtagccg ctctgcgcga tcccctcgac gaacgcggcg gcggccagca
     9961 gtccgagggt cgccacgtcg gccaggagcc cgacgaagat cgccgtcatc gcgccggcgg
    10021 cgaccagcag cgagctgatc atcatgcgtt tgcgcggcaa ccggtcggcc agcacccccg
    10081 ccaccggtgc cgcgacgagt cgcccggcga gggccagggc gccgaccagt ccggctgccg
    10141 ccggtgaacc ggtcacggcc agggtgacca gtggaagcac gatcccggac gcctgtgacc
    10201 caagctgatc aattgcgccg gctatccaat agcggcggaa atcgcgaccc cgatgggtgc
    10261 tctcttccgg ctttatgtcc tggctggggg cagccgtcat tgcgtgggcc gcattgtgct
    10321 catgtttttc ccaaatctag gtgcgaggtc tgtgggggac gagttcgcgt gatccgggtg
    10381 tcaatttttc gccccaatgg tgagtggggt gcgtatgagg ctaacaatgt cgtgtgcgga
    10441 aagcaaggat tcaaatgcgt ctagttactg gcagttattc ggttgtgggg atgatgggag
    10501 aattgtgcgc gtctgtcggg taatccgcgc tacgcgccga acctccgaac agcacccgga
    10561 accggccgct taatagacgg caatctccgc taaattctga ttttcgacgt tgttgcggga
    10621 gtcgccgccg gccccgccca cccgggtccc ggctccgccc gtcatgccgg ggcccgggtg
    10681 ggcgcgtcat gccacctggc accggcggcg gcggaggccg gccgctgcca ggtggccggg
    10741 cgggccggcg gtcaacccgt cgtgcagctc ggcaccggga tgccggggtt gccggtggac
    10801 gagccgagga acccgaacga ggtgctggcg cccgcggcga gcgcgccgtt gtaggcgacg
    10861 ttgcgggcgg tgaccgtcgt gccctggctg gtcacggtcg cgttccaggc ctgggtgacc
    10921 cgctcgccac tggcgtacgt ccaggtcacg gcccagttgc tgatcgccga ggtgccggcg
    10981 gtgacccgta cctccccctg gaacccgccg gtccactggc tggtcaccgt gtacgtcgcg
    11041 gtgcagcgcg cggtgcccgg aggtggggtc gtggtcggcg gcggcggggt cgtcgtgggt
    11101 ggcggagtcg tggtgggcgg cggggtcgtg gtcggcggcg gtggggtcgt ggtggggggc
    11161 ggcggagtag tggtgaccgg gccaccccag ccggcggtgg agtccaacca ggccgcccgg
    11221 cgcagcatcc agtcccgcat ggcctggacc tggccctgcc aggtcgacgc ggtcggggtg
    11281 tagaaggggc cgaccatcgg cgcggtcagg ttgggccagc gctggaagtt gcgctgcgcg
    11341 gcgttggtca gcggtgtggc cagggcgctg atccgggtct gtagggcggt gtcggcgagc
    11401 aggccccggc gcagcgtctg ccagcgggac cggagctggt tgacgaaggc cggatcgcgt
    11461 accagttggg ggaaccagtc gttggccacc ggctgccggg tctgctggta ctgccaaccg
    11521 gcgatctggt cgttgccgaa gtagccgccg acgccgaagg tgaggtcgta gtcccacagc
    11581 gggccggcga agatcttggt gtcgcggtcc ttgtagaagt acgcgctgcg gatgtaggag
    11641 tccatctccc ggctgagttc gttgaggacc atctggtcca cgaacgagtc gacgtcgatg
    11701 tacttccggt agccggtgac cgggtcggcg gagttcgccg cccgcagcac gttgtggaat
    11761 tcctgcacgt agccccgcag ccagtcccgc tggggcgcct gcaacggtga cgggtcccgc
    11821 acctcgagat agttccagca ggtcgccgcc ggcccggtgc aggtcagcat cggctcctcg
    11881 gcggccagcc actcgaagct ccagatgtac ccgccctgga tcttgggcag ggtca
//
