LOCUS       NZ_LT607410            26454 bp    DNA     circular CON 12-DEC-2024
DEFINITION  Micromonospora purpureochromogenes strain DSM 43821 chromosome I.
ACCESSION   NZ_LT607410
VERSION     NZ_LT607410.1
KEYWORDS    RefSeq.
SOURCE      Micromonospora purpureochromogenes
  ORGANISM  Micromonospora purpureochromogenes
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Micromonosporales; Micromonosporaceae; Micromonospora.
REFERENCE   1
  AUTHORS   Varghese,Neha. and Submissions,Spin.
  TITLE     Direct Submission
  JOURNAL   Submitted (20-JUN-2016) DOE - JOINT GENOME INSTITUTE, 2800 Mitchell
            Drive, Walnut Creek, CA 94598, USA
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_900091515.1-RS_2024_12_11
            Annotation Date                   :: 12/11/2024 12:12:47
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.9
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,188
            CDSs (total)                      :: 6,117
            Genes (coding)                    :: 5,981
            CDSs (with protein)               :: 5,981
            Genes (RNA)                       :: 71
            rRNAs                             :: 4, 4, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 4, 4 (5S, 16S, 23S)
            tRNAs                             :: 56
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 136
            CDSs (without protein)            :: 136
            Pseudo Genes (ambiguous residues) :: 0 of 136
            Pseudo Genes (frameshifted)       :: 48 of 136
            Pseudo Genes (incomplete)         :: 97 of 136
            Pseudo Genes (internal stop)      :: 4 of 136
            Pseudo Genes (multiple problems)  :: 12 of 136
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 04:07:08
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 4411675
            Orig. end                         :: 4438129
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            LT607410.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..26454
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="13"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..26454
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..26454
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:16454](+)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..16454
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     misc_feature    complement(948..963)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 16.74"
                     /tool="antismash"
     misc_feature    complement(1333..1347)
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 20.13"
                     /tool="antismash"
     misc_feature    complement(1333..1348)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 20.27"
                     /tool="antismash"
     misc_feature    1486..1501
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 21.27"
                     /tool="antismash"
     misc_feature    1502..1516
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 18.37"
                     /tool="antismash"
     misc_feature    complement(2516..2530)
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 18.69"
                     /tool="antismash"
     gene            complement(2961..3938)
                     /locus_tag="GA0074696_RS20375"
                     /old_locus_tag="GA0074696_4109"
     CDS             complement(2961..3938)
                     /EC_number="2.7.1.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) APH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF013775.5"
                     /locus_tag="GA0074696_RS20375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GA0074696_4109"
                     /product="aminoglycoside phosphotransferase family protein"
                     /protein_id="WP_088962577.1"
                     /sec_met_domain="APH (E-value: 1.4e-11, bitscore: 43.3,
                     seeds: 156, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTALSDAVASEIRGHLNEVCAQIGVDPESASLVKYTMNAVFVAP
                     PFVIRLAAGPHAATLARRVVSVAASLEQVGMPTVRLASGVTSQPVFSGDWVATAWQYVP
                     TANDEPMPVDLAAPLRALHSLDGLDVPLPRWSPIEKFRRRLDAAAALPPKEAGELEQWS
                     RTELGIPVADLLRDLHLRCDEVEEDLDRVVWRLPPGVIHGDAHTGNILLPAPGDGAAAR
                     PEPLLCDLDGMCIGPREWDLVPTAHGATRFGRSAADYRNFVDAYGADITKWAGWPILRR
                     VRELQLVTSTIDALAGRPDVAHELAHRLRSLFSEDLKATWRRYR"
     misc_feature    complement(3078..3080)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(3938..5311)
                     /locus_tag="GA0074696_RS20380"
                     /old_locus_tag="GA0074696_4110"
     CDS             complement(3938..5311)
                     /GO_function="GO:0005515 - protein binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024816.5"
                     /locus_tag="GA0074696_RS20380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GA0074696_4110"
                     /product="tetratricopeptide repeat protein"
                     /protein_id="WP_088962578.1"
                     /transl_table=11
                     /translation="MQRVVRPQWWHEGTYRDVAIRVHLARHDIGAVFGFLKERGFSWSA
                     IASATGLGASRVSEIAAGRRIVTDYAVLERIVEGLCIPRHYMGLALDEQALHHRQGASL
                     NPACVAAPLDPRELLGVVASIAVGAIPAGVERWLPNSHEVAVPAAVGQDEVATVRAVTA
                     FHRRLDAAAGGGRCLQSARGYVAWATQLLQMKCTDLVANELRASLAELHNLVGWVAHDL
                     DDHDMARRHLTQSLVLARQTDALPLLANSLYRLGRVSLHQEQPAEALQLFGLGQLAAQQ
                     AGCHASVGMLHANSAWAYALLGADHQVVDSLTRARRELDQADLDSAPAWTHFALTEAEV
                     HGISAVVYSALARHPEHVRYVDRAAEHSHQAVRLRRPQDRRSFIFDTISVATASILAGD
                     LATAGEYGMKAVGLVADGMRSARVNDRLNALWELAAPQAEREPALAALGSRIAELQAV"
     misc_feature    5457..5477
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 20.24"
                     /tool="antismash"
     gene            5513..>5836
                     /locus_tag="GA0074696_RS20385"
                     /old_locus_tag="GA0074696_4111"
                     /pseudo=""
     CDS             5513..>5836
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076612118.1"
                     /locus_tag="GA0074696_RS20385"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="GA0074696_4111"
                     /product="IS3 family transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MTSEGPRADRPRRRSFPPAEKLRLLAGYEQAVAEGDGNGYLRRNG
                     LYSSLMSEWRRARDAGLLEGKKPGQSVGRPSGEQAEIARLRRELELANRKIARTEAALD
                     IMGK"
     gene            6060..7328
                     /locus_tag="GA0074696_RS20390"
                     /old_locus_tag="GA0074696_4112"
     CDS             6060..7328
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1242: transposase"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018829460.1"
                     /locus_tag="GA0074696_RS20390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GA0074696_4112"
                     /product="IS110 family transposase"
                     /protein_id="WP_088962580.1"
                     /transl_table=11
                     /translation="MLESTQNNEEIIERIAALDIGKAELVCCVRVPGQGPGGRRRQEVS
                     THSTMTRSLLVMADRLHELGVTRVVMESTSDYWKPAFYLLEAAGFDTWLVNAKDVKHLP
                     GRPKTDRLDAVWLCKVAERQMIRPSFVPPAPIRELRDLTRYRVDLISTRTAERNRVEKL
                     LEDAQIKLSVVASDIFGLSGRDMMAALIAGQRDPKALAQMARSRLRTKITQLEEAFVGR
                     FTDHHGFLLAKMLARVDAITADIADVDQRIEEQIGPFIDAGRRLDEIPGVGPATAHVII
                     SEIGVDMSRFPTPAHLASWARFAPGVKESAGKKKGAGFTGHGNPYLARVLGEAAVAAGK
                     TDTFLGERYRRIARRRGNRRAIVAVGRSILTVVWHLLADPTTRFTDLGSAFYDTRVNPE
                     RRKRNHVRQLEALGYTVTLASAA"
     misc_feature    6069..6082
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 18.47"
                     /tool="antismash"
     gene            <7402..8478
                     /locus_tag="GA0074696_RS20395"
                     /old_locus_tag="GA0074696_4113"
                     /pseudo=""
     CDS             <7402..8478
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1026: transposase"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076611928.1"
                     /locus_tag="GA0074696_RS20395"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="GA0074696_4113"
                     /product="transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="STRALGRDLRERGHRHQADQALTDAHTQLLAAATSTRSAARLTGI
                     ARSTAHRRARTPGGCAPASRPAPVNRLSDAERAHVLAVLDSDRFVDTTPTEAFATLLDE
                     GVYLASISTLYRILRTNDQVVDRRRQARHPTRARPELTATGPGQVFTWDITKLPGPTKG
                     AYYDAYVMIDIWSRYIVGHHVAARESAETAHDFITEVIAVHGVPQVVHADRGTSMTSKR
                     VATLLADLHVTRSHSRPRVSNDNPFSEAAFKTVKYHPTFPERFGSLADARAYCDTFFGW
                     YNHEHHHTGIGLHTPADVHYGHAATQQKQREQALDTAWTAHPERFSRRPRPKTLQLPDA
                     VWINPPKPATDQPLPQAA"
     misc_feature    8600..8615
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 20.81"
                     /tool="antismash"
     gene            9020..9265
                     /locus_tag="GA0074696_RS20400"
                     /old_locus_tag="GA0074696_4114"
     CDS             9020..9265
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="GA0074696_RS20400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GA0074696_4114"
                     /product="hypothetical protein"
                     /protein_id="WP_088962582.1"
                     /transl_table=11
                     /translation="MTREHLKVPRRFALVRYPDGDDSRVIVAWGIELPDGSAVSVSIND
                     EAVAVCSRAAHCELIHSAELIWIDDATGDVELEGTP"
     gene            9724..9882
                     /locus_tag="GA0074696_RS20405"
                     /old_locus_tag="GA0074696_4115"
     CDS             9724..9882
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LD_lanti_pre"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018829768.1"
                     /locus_tag="GA0074696_RS20405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GA0074696_4115"
                     /product="FxLD family lanthipeptide"
                     /protein_id="WP_088962583.1"
                     /sec_met_domain="LD_lanti_pre (E-value: 2.2e-13, bitscore:
                     48.4, seeds: 21, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAIGTLELSATGSDDEFDLDVSLLEVADLAGLVNLTDDGCGSTCT
                     ACTTNVA"
     gene            10001..13075
                     /locus_tag="GA0074696_RS20410"
                     /old_locus_tag="GA0074696_4116"
     CDS             10001..13075
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018805746.1"
                     /locus_tag="GA0074696_RS20410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GA0074696_4116"
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_088962584.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 1.2e-200,
                     bitscore: 666.4, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 7.4e-18,
                     bitscore: 63.5, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 9.6e-21, bitscore:
                     73.1, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTALVRAVAHPAIELPPWPDLTEPRPELVTSWVSWLRQVWAIDA
                     VAEAVTLSSPVLAEQVSKLCAEESPSVREARRTVHAVARYAQRLLGRPTPFGLLAGVAP
                     AVFGSRAPTRWGTAHRAIARAGAGWLTDVIAQFERCPELLSRLSVVANSTLTVRDDRLI
                     VPYQPHPGIDGQLGAVEVSLRHSAPVRAAIDAAHSPIRVEVLASQVRETFPQASAAVVM
                     AMLTQLIAHGALITSLHAPSTEPDALGHLLRQLDEVGAGTVTPIADFMGSLQEVHAGLQ
                     RHNSAPPGDAPAARRLVASRMRSLALSAHEPLAVDLRLDASVTLPDQVATEVERAALVL
                     TRLSAYPYGTAAWRAYHQRFYERYGIGSLVPVREVVDPDSGIGLPDGYPGSPAAEPRSP
                     ISRRDEVLLSVAQRAALDGTMEVVLDEALIAQLELGPQRLRLPPHLEACVRVQAADEED
                     LARGRFTLEVTSVSRAAGGLTGRFLSVLRLTDAGRLGAGLTDLPASDRDTVAAQVSFPP
                     LDPGTAHVARAVQVLPTVISLAEHRWPSRAVLTVGDLAVGCDGRRMYLAVPDRGHRIEA
                     VGLHALNLRTHTPPLARFLIELGRAQCAQVTAFDWGTAARAKLPFLPRVRYGRAILAPA
                     TWRLEAAELPDQHQPWYAWDDALDEWRARRRLPRLVHLVEADRRLPLDLDESAHRVLLR
                     THLLTAPRAVLVEAPAPENLGWCGGRPHEVIVALHATEPPPWPPLPTPTPARVIGRDQG
                     QAPASSRILLAKLYGDIRRQDLLLAEHLPRLIAQWDAPPDWWFLRFRDPDQHLRLRIAL
                     PDVSAFGPAAERISAWADDLHRRGLLREVQYATSYPETGRWGSGPAMQAAEAVFIADSH
                     SVLTQLRQPVRPSRQALVAAHTAAIAVAFTGSVDAGMRWLVDHVPATAPQPVPRPLFRE
                     AVHLAHPGGDWATLRAAAGGTAIVDAWKNRDVALAVYRTHLPGPHTDGIDVDDVLGSLM
                     HAHYIRAVGIDFDDEDQCRYLARAAALAYFARSRS"
     aSDomain        10445..10723
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_GA0074696_RS20410_Lanthipeptide_LanB_
                     RRE.1"
                     /evalue="3.40E-20"
                     /identifier="RREFam001.1"
                     /label="GA0074696_RS20410"
                     /locus_tag="GA0074696_RS20410"
                     /protein_end="241"
                     /protein_start="148"
                     /score="63.5"
                     /tool="antismash"
                     /translation="VVANSTLTVRDDRLIVPYQPHPGIDGQLGAVEVSLRHSAPVRAAI
                     DAAHSPIRVEVLASQVRETFPQASAAVVMAMLTQLIAHGALITSLHAP"
     misc_feature    11999..12001
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            13072..14364
                     /locus_tag="GA0074696_RS20415"
                     /old_locus_tag="GA0074696_4117"
     CDS             13072..14364
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019901917.1"
                     /locus_tag="GA0074696_RS20415"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GA0074696_4117"
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_088962585.1"
                     /sec_met_domain="LANC_like (E-value: 1.2e-45, bitscore:
                     154.3, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSLAYESHELAVAVADLLTHPNDPSLPIHQPWWRQSLALGVPGIA
                     LLHVELAAAGLRPWQRAHHWLAAATSGPVTAGADSHPFHGAPALAHVLACAAAHQPGTY
                     ARALDGLDTAIAADARRRVHAAHARIDARKLPALAEFDAIRGLTGVGAYLLRRAPDGPE
                     LRAVFQYLVRLTQPLHPDGEVLPGWWTGSSPSGRADARFPGGHGNSGMAHGIAGPMALL
                     ALAALHGVVVDGQLTAISTICAWLDRWRSDTDGGPIWPYWITRPQLRADHAQVLRTQRP
                     SWCYGTAGLARAQQLAALALNDPVRRAAADGALVCALADLHQLAATTDPSLCHGYAGLA
                     HIAHRVAADALPDVAEHLRALVPRLLDQIGPSGADPRRTAAALVSDAARPGLLEGAAGV
                     ALAALSCSTAATASSSWDACLLTNRPAHPLT"
     misc_feature    13624..13626
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            14379..16454
                     /gene="fxlM"
                     /locus_tag="GA0074696_RS20420"
                     /old_locus_tag="GA0074696_4118"
     CDS             14379..16454
                     /GO_function="GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="fxlM"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PCMT"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Methyltransf_3"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR04364.1"
                     /locus_tag="GA0074696_RS20420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GA0074696_4118"
                     /product="methyltransferase, FxLD system"
                     /protein_id="WP_088962586.1"
                     /sec_met_domain="Lant_dehydr_C (E-value: 3.5e-32, bitscore:
                     110.7, seeds: 35, tool: rule-based-clusters)"
                     /sec_met_domain="PCMT (E-value: 1.3e-45, bitscore: 154.3,
                     seeds: 9, tool: rule-based-clusters)"
                     /sec_met_domain="Methyltransf_3 (E-value: 1.2e-05,
                     bitscore: 23.2, seeds: 4, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPTPAWRQYTVEFPTPSAAEDIAASALAPALTAAQNDGVLHGWWY
                     VRKYPTWRWRYVADDPTSHLVEDLLETLAIEDGIINWTRGVYEPEMLAFGGTAGMHVAH
                     ELFHQDSHHLLLRPAAAPTVLGRRESAVLLCSVLMRSAGLDWYEQGDVWAKVTELRPSP
                     AIPAEDQAASLTRSINRLMTVDARSLSQPDSGGPLMGYGAWLDAFENAGQALADLARQG
                     RLRRGLRSVLAHHVIFHANRMGLSVRDQSTLAALAVRNVFHTTTRSTMSTSAPTPPTTS
                     VDRVTTLREPTDLRTELTDRLRAENVIRTPAVEAAMRRTPRHLFLPGVPLQQAYVDGPV
                     YTKTDGSGTSISAASQPRIVAMMLEQLDAQPGHRVLEAGAGTGYNAALLAAIVGDSGRV
                     VTIDVDDDLVAGAREHLAAAGVANVEVVHGDGALGHPDGAPYDRIIATVGAWETPTAWL
                     EQLAPDGRLVVPLRLRGAASRSIIFERHAGGWRDNGSELAVFMPLRGIGDDARRLVALS
                     PEQDVTLQVHKDQEVDAAALAGVLDTERQEMWTDVLFPPMVPYEWMDLWLACRLDNAIM
                     RMNVRPASIERGTVTPMFPWGAMATTRGADLAYLTIRPAPPAADGRKMYEVGVIGHGPG
                     GKDLAQHVSEEIRTWDADYRSRTVRFDISDAPVEADPSAGRFVLPSSHHPITVTWE"
     gene            16458..17594
                     /locus_tag="GA0074696_RS20425"
                     /old_locus_tag="GA0074696_4119"
     CDS             16458..17594
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019901919.1"
                     /locus_tag="GA0074696_RS20425"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GA0074696_4119"
                     /product="hypothetical protein"
                     /protein_id="WP_088962587.1"
                     /transl_table=11
                     /translation="MDPNSPILRRFPLVARPRPIAKALTARIDDLRTLANRADREDDMT
                     AASAVYNRAALIASDCGQPELARQWCHEHADAYLRAFPLGTQAARHALEPLVNLARLHI
                     RSGDGDAALRLLTDLFQAASSRTDALIDGYSLLASRLTRTAEDHREVRQWLWSVLLAEG
                     ARALTSADRWKEAYDHLQRHNGIGRRMLDGRQVAVIAHATAGEIEHARTLVAETACGEP
                     WEQSVTACLDYLCGKAAGEETFLDALLDSYRRLTPTPSLAVFHTRLGLSIIDAAGGVAH
                     PGVRNLAAELINQAVAFDDAHVARDLLDHGGIRAVVDAQGEAELVTILHAGGTAGRRLP
                     CVAHERLFQSLAVSRAVIQRLPLGQHRRVGAASAESGR"
     gene            17628..18305
                     /locus_tag="GA0074696_RS20430"
                     /old_locus_tag="GA0074696_4120"
     CDS             17628..18305
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007460938.1"
                     /locus_tag="GA0074696_RS20430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GA0074696_4120"
                     /product="hypothetical protein"
                     /protein_id="WP_088962588.1"
                     /transl_table=11
                     /translation="MTAYEIAARLPTIDLLRRRCKALAVLERIIDGGEPYYGYTSAWGA
                     DEAALMSNGSGDEWAAVFTADGAFIRVFDHESAMSPYRDPDHELWPGLLDGIPKVLRPQ
                     VEEPAFCDEAGQFIATAVLWRLAGDDVWHAGEGITFPPVQGPYADTGPDGSGMLDILLD
                     DIVDRFVEFASDYYEIEVDRAAVEHVVAHRPLTDTVIQALNPRLTVADLREDIAAIYPI
                     ASM"
     gene            18472..20268
                     /locus_tag="GA0074696_RS20435"
                     /old_locus_tag="GA0074696_4121"
     CDS             18472..20268
                     /GO_function="GO:0043531 - ADP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1041:
                     transcriptional regulator, SARP family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF013124.5"
                     /locus_tag="GA0074696_RS20435"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GA0074696_4121"
                     /product="tetratricopeptide repeat protein"
                     /protein_id="WP_088962589.1"
                     /transl_table=11
                     /translation="MLIVKLRRVTVAGLVAAGVAAVTLMIGLVTNAASNQQRWPGWLSL
                     VQRYPWQSFLLLAVVAVVLAALLPGLTDPGQVGMRIADDEPTPSVGAAAVLRTLPRDVA
                     GFTNRRDEIEQILNDASHDQLIVPVRTIDGMAGVGKTAFAIHVGHLLAPKFPDGQLFLN
                     LNGHTPGRGPVGPAEALASLLLADGVAPQKIPNSDDQWAMTEARAAMWRTRVADRRMLL
                     ILDNAATYAQVEQLLPGAAGSLVLVTSRRRLAAPDATSLQMSALSATDAAALFMRLAGR
                     SRLSKESVGELVAVCGYLPLAVALLAARLRHHPSWTVENLKDRLLSTQHRLVEMQAGER
                     AVAAAFDLSYQDLPVERQRFFRRLSRFPGLDVDEEAAAALASVSWAVARAELEALYGDH
                     LLDETEHGRYRFHDLVRDYGRSLGEDGQDGTMSIKNLAGHYLETIGAANTYISRGSTTT
                     TARFDSLATASAWLDAERANVLACVEECVRREQHALVVGLAAAMAPYLRQAGPWDQAAE
                     LHRTAVVAARRTGDRKAEADALANLGMVSRLMARYRAAVETLNESLAIYLALGDLDGQA
                     LGPVWSCDHGGVEAGRSAAPCW"
     misc_feature    18844..18846
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    19384..19386
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    20200..20202
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            20278..21275
                     /locus_tag="GA0074696_RS20440"
                     /pseudo=""
     CDS             20278..21275
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1097: transposase"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076612357.1"
                     /locus_tag="GA0074696_RS20440"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="IS5 family transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MTRRELSDDEWALVEPFLPIEAYGPYPQRLRDQFEGVIWRFRTGS
                     QWREMPTEFGAWQTVYDRFTQWRDAGVFAALMEGMIAEAARRDQADLSLVSVDSTVARA
                     HHDAAGMVVDTAVLAALEQAAGAKRGILDAGKPPQ"
     gene            21501..22409
                     /locus_tag="GA0074696_RS20445"
                     /old_locus_tag="GA0074696_4124"
     CDS             21501..22409
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007457326.1"
                     /locus_tag="GA0074696_RS20445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GA0074696_4124"
                     /product="methyltransferase domain-containing protein"
                     /protein_id="WP_231925094.1"
                     /transl_table=11
                     /translation="MSSSQPVVDPGPEPDTTAGGPVNTADARSRPPSPDAPESSPDHRY
                     LLDNARVEAGERFTWLAELFDGVTRGHFDRLGVRAGWRCWEVGAGGPSIPEALATAVGP
                     TGYVLATDINPAWLDPHGGYEVLRHDIVGDPPPQPGTFDLVHARLVLVHVPDRARALAT
                     MVAALRPGGWLLVEDADTELQPLACLDEVGPAQRRANRLRRAVRELMTRRGADLRYGRT
                     LPRALRAAGLVDVTAAGCFPVGGVACDRLETATVRMLRAELLAAGLANEVEIDAHLAAV
                     DAGELDLTLAPLISAWGRRPG"
     gene            22508..23461
                     /locus_tag="GA0074696_RS20450"
                     /old_locus_tag="GA0074696_4125"
     CDS             22508..23461
                     /GO_function="GO:0005515 - protein binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1041:
                     transcriptional regulator, SARP family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF024816.5"
                     /locus_tag="GA0074696_RS20450"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GA0074696_4125"
                     /product="tetratricopeptide repeat protein"
                     /protein_id="WP_172894360.1"
                     /transl_table=11
                     /translation="MLNQLGIVHYLTATYDEAARAQTEALGICRENGDLLGQANALADL
                     GMVRRMTGDLGPSAEASTEALEIYRQLGDRYGEANALRDLGLVRSLTGDYAESEHNARE
                     ALAIYTSIGDPVHQAYALNELGVARRLQGDLEGATESHEQALAKYIELGDRFGEANAIR
                     HLGVLHRLRGDQAAAVEAQERAVTIYAELESRGGMAAATAELGVLRRLDGNLVGARSAL
                     DSAAAWYAELGDRTGQLEVHNHIGALHLDAVELDRASNRYELALSLARELGVPLQEAHA
                     LEGLARCELALGRPEQAADLRSAAKMLHERLGNRHT"
     gene            23510..23650
                     /locus_tag="GA0074696_RS30905"
                     /old_locus_tag="GA0074696_4126"
     CDS             23510..23650
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="GA0074696_RS30905"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GA0074696_4126"
                     /product="hypothetical protein"
                     /protein_id="WP_157746061.1"
                     /transl_table=11
                     /translation="MQQSTTSNVQPVLATVVKRVHARIAAEQVKPEAVRAAHAASIPAQ
                     S"
     gene            23670..24179
                     /locus_tag="GA0074696_RS20460"
     CDS             23670..24179
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PTHR43273"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) QueE"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF015983.5"
                     /locus_tag="GA0074696_RS20460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="radical SAM protein"
                     /protein_id="WP_088962592.1"
                     /sec_met_domain="PTHR43273 (E-value: 4.7e-41, bitscore:
                     139.5, seeds: 35, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 1.5e-06, bitscore: 27.0,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 1.6e-12, bitscore: 46.6,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="QueE (E-value: 2.3e-06, bitscore: 25.7,
                     seeds: 32, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPPLRTFILKVVNRCNINCDYCYVFNGPDQSWRGLPVRMSAEVAH
                     AAAQRISEHATAHDLDHVDAVLHGGEPLLAGPRHLGAILQILHDRVPSVRFELQTNGML
                     LNDDWLDLFEQFGVRVGVSLDGRPVANDRHRVSHRGRSTSYAAVRGIELLRSRPRAPAK
                     SSGDAE"
     misc_feature    23961..23963
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(24162..25274)
                     /locus_tag="GA0074696_RS20465"
                     /old_locus_tag="GA0074696_4128"
     CDS             complement(24162..25274)
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018789282.1"
                     /locus_tag="GA0074696_RS20465"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GA0074696_4128"
                     /product="ISAs1 family transposase"
                     /protein_id="WP_172894136.1"
                     /transl_table=11
                     /translation="MEDGAGGLLTALADLPDPRARRGVRHRLVTVVAAAVCAVVAGYRS
                     YTAIGEWVADLPADTAVLLGIDASRRPSEAMIRRLLQALDPEVLAVVIGTWLAGCTPAA
                     PAGSSRAIAVDGKTIRGSRTGDTTARHVLAAADQASGVVLASTDVNGKTNEITRFAPLL
                     DQIPDLHGVVVTADALHCQREHVAYLAERGAHWILTVKGNQPSLHHQLAALPWRAVPDA
                     DRDTCRGHGRREIRTLKILSVSTGIDFPHAAQALQIRRRRRRLDQPKRFTTETVYAITD
                     LLVHQARPAQLASWIRGHWSIENRVHWVRDVTYDEDRSQIRTGTGPQVMAALRNAAIGA
                     LRQAGVTNIAAGNRHHARDSNRPLALLGIT"
     gene            25513..26109
                     /locus_tag="GA0074696_RS20470"
     CDS             25513..26109
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PTHR43273"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="GA0074696_RS20470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_088962593.1"
                     /sec_met_domain="PTHR43273 (E-value: 7.5e-32, bitscore:
                     109.2, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVDLHNDPAEVHDYLASLGPAVIDFNLPHATHDAPPERADPTEPE
                     YGRWLSRVYDAWTGASSYTHSVRILEDIVALSLGVKGSVESLGLAPADIVVVESDGSIE
                     NVDTLKAAAPGAADLGLNVFDHTFDEVANHPAIRQRRAGVAALAQECQRCPLVSVCGGG
                     YLPHRLSAERGYRNPSVYCQDLAHLIRHVQATLPA"
ORIGIN
        1 aggcgggcca cgactccgtc cagaccgatg cgggcgagtt ccctcctgtt gggctcgttc
       61 gtcccgctgg cgggcttggg ctcagcctcg actgtgggga ccggcgtcag ctcctgctcg
      121 tgcagcctgg ttcgccactg cttgagacgc tgctgcagct cgccgcgggt cttggcgccg
      181 agcccgggca gggtgaacag gtccttggag cccagtgcca agagttcacc gacggtatgt
      241 gcattgagcc ggtgcgcagc ggagactgca cggagagtca agccggaggc ctcgagcacg
      301 gtgacacgcg tcgcccgccc ggcggctgcg tcgcgctctt gcgccgtatc ttcatcttcg
      361 gggtgcacgg atccgacggg cgcggtccgg tcggaacggc ggaagacctg ctgccactcg
      421 gcgcgcattt cgcgcaacgt ggggaagcgg cgctttgcgt cgcggtcgag cgcacgggag
      481 aagaaggcga cgaggccttc acgaattgct gagtcgaacg cttcgaccgc cagcgtcggt
      541 ggcccttcgg tgaatcggac ctcggtgctg ccgtctcccc acataggcag ttcaccggag
      601 gccatctcgt gcagagtgac cgcgaccgcg taccactcgg cgtggtcgtc gtacacgggc
      661 cggttcggcg tgccgagaaa ggggtcgagg tagccaggag tgccggcctc gacctccgtc
      721 accgcagctg ctgacaacga gaagtcgaag agcactagtt gccgggtgcg attcttgcgg
      781 actcggatgg cgatgttgtc cggtttgatg tcgcggtggt agacgccctc gccctgcaga
      841 tggtccacgg cgtggaagag gtagtcggag tatgtctcca gctcgtcaac ggtgagccgg
      901 ccgtcctcac gcagtttgcg ggcaaccgtg accgatccgg cgtgttcgag gacgatcatc
      961 gttcgcgggg gaatctcgat cggctcctcg cgagcgaggc ggatgacacc ggaatcctgg
     1021 ctaattcctc gcagcacccg ggcctcgtgt tccagccgag tgcgcttttc gtcggagagc
     1081 gcgaccttga ggacctcctc ggctccggtc tgcaggttct ccgccaggaa ggcacgcgag
     1141 gtcgagccag tgccgagctt ctgcttgatc ttccagtcgg acaccacgtc accggggcgt
     1201 gcctcgagca ggtcgattgc ctgcaccggc tcgacggccg gtgcagtcag ctcctcctcg
     1261 acgcatacga gcaggtcgag cacctcggcg acagtggcca gccgccgagc tggaacaggg
     1321 gccgtcgcgg cttggaccag ctcgtccatg aattcggaga ccgagtcggc atcggccgac
     1381 ggacgcaggc cgttctcctt cgccagtcgc gtcatcagct cagcccggct ggtcgctggc
     1441 gctttgccgg aaagcagcag ataggagagg gttccgaggc cgaagacgtc gagagcgatc
     1501 gggtccgtct cggccaagtt caactcgggc gcgagatagg cttcggccga tcgctccagg
     1561 tgggccccct cacgggtcgc ggtcgccgcg atccccgacc ccccgctggt cgactcgctc
     1621 tcccggacgg ccgcctgcca gtcactgatc tgcaactgcg ggtcggccca cggattctcg
     1681 cccgccgtac gtgcccgtcc aggcttgacc agaacgctgc gcgccgcaag cgctcggtgg
     1741 taaagcttgc gcccgtgcgc gtacgccatc gcctcggcga gctgacggat catgtcgagc
     1801 cgggtgccaa tctccagctt ctcgccgtac tgggccatga aatggtccag acgcatcgcc
     1861 tgatggtcgt gccggaagat cagcgcgggt ccgccctcgt gcggttccat accgtcgacc
     1921 tgcacgatgc caggatggct gatgccgtgc agcgccagca tctcgcgacg ggcggcgcgc
     1981 tcgatgctgg cccgcaccgt cttcgcggag ttgcgctcta cgaggtagat ccggacgcgc
     2041 cgctgctcct tcggaaactg cgtgtgcctg gccaggtggt cctgccaggt cgggccgacg
     2101 tcccacggct tgccatcgag tttccaggaa ccgacttggt agtaccggcg gctgcggccg
     2161 acgcccaccc cgtccaacag cttgccgagt gcacgcgatg ctgccgcggt gagctgacgt
     2221 tgcggctcgt cacgcggtgt gcggccgagt agacccgacc agactcccgg caaggctgcc
     2281 gattcagccg atgcctgctc cggaccgaaa acccagtgca gttggtgcgc gtccagcgcc
     2341 acttgcagac tgggaaccga gaggaagacc gcaccctgga tgaagggaat acgttcctta
     2401 ccgccggatc ggtggacctg tgcggtcagc agcgagcgca ggcgcttcgc cttgctgtca
     2461 gccagatgca gagggttgtc gaacgtacgc accgattggt tgttgagcat ccaggtggaa
     2521 ccgctgttcc agagccggcc gtgcagactc ttgacctcga tgaggtagat gccacccggc
     2581 gccacaacga ggagatccac ctcgtgcacg tgaccggtct cggccgtaaa ggtaaagttt
     2641 gaccaggcac gatagggctc agagtccggt agcaagccgc gaatgtgttc gagcgcttcc
     2701 cgctcatgct cgaactgcga cggagtaacc gtggtccagc gcccctcctg catggcgtca
     2761 ggctagccgg tcgccgtcgg acagcaggga acgccaccag ccatcgacgc tgcgcaccag
     2821 agagccagct caacgtacgt cccaccgata gggtgacgtt cggttgatgc cgcatcgttg
     2881 gggaggctgc gccgggcacg ctcgcacagc tcctgggccg ccctctggcg atggctgatt
     2941 ccgcctcgtc accccagtca ctaccggtag cgacgccatg tggccttgag gtcttccgag
     3001 aagagtgacc gaagcctatg ggccagctcg tgggctacgt cgggacggcc agcgagcgcg
     3061 tcgatggtac tggtaactaa ctgcagctcc cgtactcggc gaaggatcgg ccagcccgcc
     3121 cacttggtga tgtcggcccc gtaggcatca acgaagttcc gatagtcggc ggctgagcgc
     3181 ccgaagcggg tagctccgtg ggcggtcggt acgaggtccc actccctcgg accgatgcac
     3241 atcccgtcca agtcgcagag cagaggctcc gggcgagcgg ccgcaccatc acctggtgcc
     3301 ggcaggagga tgttcccggt gtgcgcgtcc ccgtggatga cgcccggcgg cagccgccac
     3361 acgacccgat cgagatcctc ttctacctcg tcgcagcgca ggtgaagatc acgcagcagg
     3421 tcagcaaccg ggatccccag ttctgtcctc gaccattgtt caagctcgcc ggcttccttg
     3481 ggtggtagcg ctgcggcagc atcgaggcgc cggcgaaact tctcgatcgg cgaccagcgg
     3541 ggcaacggta catcgagccc gtcaaggctg tggagcgcac ggagtggcgc agcgaggtcg
     3601 accggcatgg gctcgtcgtt ggcggtcggg acgtactgcc atgcggtggc gacccagtcc
     3661 ccgctgaaga ccggctgaga cgtcaccccg gaggccagcc gcacggtagg catgccaacc
     3721 tgctccagag acgccgcgac cgacaccacc cggcgggcga gcgtcgcagc atggggaccg
     3781 gcggcaagtc tgatcacgaa cggcggcgcc acgaacaccg cgttcatcgt gtacttgacg
     3841 aggctggcac tctccgggtc gacgccgatc tgagcacaga cctcgttcaa gtgcccacgg
     3901 atctccgagg cgacagcatc gctaagtgcg gtggtcatca gaccgcctga agctccgcga
     3961 tccggctgcc gagagcagcg agcgccggtt cccgctcggc ctgcggcgcg gcaagctccc
     4021 acagtgcgtt cagacgatcg ttgacgcgag ccgatcgcat gccgtccgcc accagcccga
     4081 ccgccttcat cccgtactcg ccagcggtag cgagatcacc ggccaggata ctcgcggtgg
     4141 cgaccgagat ggtgtcgaag atgaaggacc ggcgatcttg cgggcggcga agacgcaccg
     4201 cctggtggga atgctcagcg gctcggtcta cgtagcggac gtgctccggg tgccgggcca
     4261 gggcggaata gacgacggcg gagattccgt gtacctctgc ctcggtcagg gcgaagtggg
     4321 tccaggccgg cgcgctgtcc agatctgcct gatcaagctc acgtcgtgcc cgggtcaggc
     4381 tatccacgac ctgatggtcg gcgcccagga gcgcgtaggc ccacgcggag ttggcgtgga
     4441 gcatgccgac gctggcatgg cagccggctt gctgtgctgc gagctggccg agaccgaaca
     4501 gttgcagcgc ttcggccggc tgttcctggt gcagactgac ccgccccagg cgatacagcg
     4561 agttggccag cagcggcagc gcgtcggtct gccgcgccag gacgaggctt tgggtgaggt
     4621 gccggcgcgc catgtcgtga tcgtcgaggt cgtgcgccac ccagccaacg aggttgtgta
     4681 gctccgcgag ggaggcccgc agctcgttag caaccagatc ggtgcacttc atctgcagga
     4741 gctgcgtcgc ccaggccacg tacccacgtg cggattgcag gcagcggcct cctccggctg
     4801 ccgcatcgag ccggcggtgg aaggcggtca cggcacggac ggtggccact tcgtcctggc
     4861 cgacggcggc cggaacggca acctcgtgcg agttgggtag ccaccgctct acgccggcgg
     4921 gtatggcgcc taccgcgatg cttgcgacga cgccgagcag ctcgcgggga tcgaggggcg
     4981 cggcgacgca ggctgggttg agcgatgccc cttgccggtg gtgaagcgcc tgctcgtcga
     5041 gggcgagccc catgtagtgg cgcggaatgc acagtccctc gacgatgcgc tccagcacgg
     5101 cgtagtcggt gactatgcgg cggcccgcag caatctccga gactcgactg gcacccagac
     5161 cggttgcgct cgcgatggcg gaccagctga agccgcgttc cttgaggaag ccgaagaccg
     5221 cgccgatgtc gtggcgagca aggtgtaccc gtatggcgac gtcgcggtag gtgccctcgt
     5281 gccaccactg cggcctgacg acccgctgca tggattgtca ctccttccca ccgcggttac
     5341 tgcgcacagt agtcggccgt gtgcgagatg tccgccctac cgcagccata ccctgggtgt
     5401 cagggttggg tgagaccagg ggttcagagc aagtagccct cccggggcga ggatggatct
     5461 tctctcgatg acgatttcca gcgcgcaact gtccgtcggg cacgatgggg ccatgacgag
     5521 tgagggacct cgcgcagatc ggccacggcg gcggtcgttt cctccggcgg agaagctgcg
     5581 gctgctcgcc ggatacgagc aggccgtcgc cgagggtgac ggcaacgggt atctgcgccg
     5641 taacggcttg tactcgtcgc tgatgagtga gtggcgccgc gcccgtgacg ctggtctgct
     5701 ggaggggaag aagcccggtc agagcgtcgg gcggccgagt ggggaacagg ccgagatcgc
     5761 tcggctgcgc cgggagttgg agctggcgaa ccggaagatc gcccggaccg aggcggcgtt
     5821 ggacatcatg ggaaaagttg cttcctgccc tgtgggcggg cccgttccgg gctgaaaatg
     5881 ggtgtggtcg cccgccgact ccgtgtgcgc ttggtctttg aggccgtgga aaagtcgggt
     5941 gcggggagct gcgccatggg cccttcactg ttgcttcgag cacgcggatc agcttcgcct
     6001 tcgtcttcag cagctcctgc gggcggcctc tcgtgaacgt cgagggtggg gaggaccggg
     6061 tgttggagtc gactcagaac aacgaggaga tcatcgagcg gatcgcggcg ctggacatcg
     6121 gcaaggcaga gttggtgtgt tgcgtgaggg tgcctggcca agggccgggg ggccgacggc
     6181 ggcaggaagt gtctacacac tccacgatga cccggtcgtt gctggtgatg gcggaccggc
     6241 ttcacgaact gggtgtcacc agggtcgtga tggagtcgac ctcggactac tggaagccgg
     6301 cgttctacct gctcgaggcg gccgggttcg acacgtggct ggtcaacgcc aaggacgtca
     6361 aacatctgcc ggggcgtccg aagacggacc ggctggacgc ggtctggctg tgcaaggtcg
     6421 ccgaacggca gatgatccgg ccgagtttcg ttcccccggc acccatccgg gaactgcggg
     6481 acctgacccg gtaccgggtc gatctgatct ccacgcgcac cgcggaacgc aaccgggtcg
     6541 agaaactact cgaagacgcg cagatcaagt tgagcgtggt ggccagcgac attttcgggt
     6601 tgtccggccg agacatgatg gccgcgttga tcgccggaca gcgagatccg aaggccctgg
     6661 cccagatggc ccgtagccgg ctccgcacga agatcacaca gttggaagag gcgttcgttg
     6721 ggcgcttcac cgaccaccac gggttcctgc tcgccaagat gctggcccgt gtcgacgcga
     6781 tcaccgcgga tatcgccgac gtggaccagc ggatcgagga acagatcggc ccgttcatcg
     6841 atgccggtcg gcggctggac gagatccccg gcgtcggtcc ggccaccgcc cacgtgatca
     6901 tctccgagat cggcgtggac atgagcaggt tcccgactcc cgcccacttg gcgtcgtggg
     6961 cccgcttcgc cccgggtgtg aaggaatccg ctggcaagaa gaagggcgcc ggattcaccg
     7021 ggcacggtaa tccctacctg gcccgggtac tgggcgaggc cgcagtcgcc gccggcaaaa
     7081 ccgacacctt cctcggcgaa cgctaccggc gcatcgccag acgccgtggc aaccggcgcg
     7141 ccatcgtcgc tgtcggccga tccatcctga ccgtcgtctg gcacctgctg gccgacccga
     7201 cgaccagatt caccgacctc ggttcagcct tctacgacac ccgcgtcaac cccgaacgcc
     7261 gcaaacgcaa ccacgtccgc caactcgaag cactcggtta caccgtcacg ctcgcgtcag
     7321 ccgcctgacc agccatctcg tgatccatcc cggctccgcc gggacgctga cgcctgccca
     7381 ctcacggttc attttcggat cagcacacgc gctcttggcc gagatctccg agagcgcgga
     7441 caccgacacc aagccgacca agccctgacc gacgcccaca cccagttgct cgccgctgcg
     7501 acgtcgaccc gcagtgcggc ccggctgacc gggatcgccc gcagcaccgc ccaccgacgc
     7561 gcccgcaccc ctggtgggtg tgcgccagcg tcgcggccgg cgccggtgaa ccgactgtcc
     7621 gacgctgaac gcgctcacgt tttggcggtg ctcgacagcg accggttcgt cgacaccacc
     7681 ccgaccgagg cgttcgcgac gctgctcgac gaaggcgtct acctggcctc gatctccacc
     7741 ctctaccgca tcctgcgcac caacgatcag gtcgtcgacc ggcgccgcca agcccgccac
     7801 cccacccggg cccgcccgga gttgacggcc accggcccgg ggcaggtgtt cacctgggac
     7861 atcacgaaac tgcctggccc gaccaagggc gcgtactacg acgcctacgt catgatcgat
     7921 atctggtcgc ggtacatcgt cgggcaccac gtcgctgcca gagagagcgc cgagaccgcc
     7981 cacgacttca tcaccgaggt catcgccgtg cacggcgtcc cgcaggtcgt gcacgccgac
     8041 cgcggcacct cgatgacctc caaacgcgtc gcgacgctgc tggccgacct ccacgtcacc
     8101 cgatcgcact cccgcccccg cgtgagcaac gacaacccat tctccgaagc cgcgttcaag
     8161 accgtgaagt accaccccac gttccccgaa cgcttcggat ccctggccga cgcccgcgcg
     8221 tactgcgaca cgttcttcgg ctggtacaac cacgaacacc accacaccgg catcggtctg
     8281 cacacccccg ccgacgtcca ctacggccac gccgcgaccc aacaaaagca acgcgagcag
     8341 gccctcgaca ccgcctggac cgcccacccc gaacgcttct cccgccgacc cagaccgaaa
     8401 acgctgcaac tgcccgacgc cgtctggatc aacccgccca aaccagcaac cgatcaacca
     8461 ctaccccaag cggcgtaaca cccactggtc tcaccggcct tgacaagtac cgatacggcc
     8521 cgccgtctca ccgtgagagc cccaccatga ggcgctcacc actggctagc tgggcgacag
     8581 caacatcggc cagggtcctt ggcatgccag ttcgacgcca ctaccaccgc caggttctcg
     8641 tgcagggccc gggagccggg gctgagcaag ctccggtgcc gaccccggcg gaaggtagca
     8701 acggccgtca ggaggctggc ccggacgggt tcggggtgag tgctgagcat gaggcccgct
     8761 cgcctcggac cagtgcgcgg tcggagagca cgcaggcgtt gacccgagac gtcggccgcc
     8821 ctcccgcccg cgctcaccgg aggtccgagt cgctcgggat cgccgtcccc cgtgccttcc
     8881 cgggccagac cgccggtgcc gtggtggcgt gccggtgccc tcgcgcgccg gcacgccatc
     8941 gcggacagct ccgtcagcag cagctctcac gggcagcagg tccctatcgc tgtgcaccgc
     9001 ctctctgcgg gagcaattca tgacgaggga gcacctgaag gttccgcgcc ggttcgcgtt
     9061 ggtgcgctat ccggacggcg atgacagccg agtgattgtc gcctggggta tcgagctgcc
     9121 cgacggatcc gccgtctcgg tgagcatcaa cgacgaggcg gtcgccgtct gcagcagagc
     9181 tgcgcattgc gaactcatcc acagtgcgga gctgatctgg atcgatgacg cgaccggtga
     9241 cgtggagctg gagggaacgc cgtgaaggcc gtcggtgtgg tcaagagtca gtacgcgcag
     9301 gcccctccgg acagcgactt ccttgcgacc gcgcgcatgg tcctggacat ccaccgagac
     9361 gacaggggct tctgcctcgg ctgctacgtc tacttccgtc agctcaagcc tttcccctgc
     9421 gagtactact cctgggcagc gcgagtgctc gccacctacc ggaggccagc gccttcggct
     9481 ggcagagcgc ccgctcgcga acgtcggcct ggtgaccctc gacccacccc agtccttcgg
     9541 ctggtaccgc cggcaacagg ctccgcttcc gacgacacgg tggtcatcca ccggaagtag
     9601 caccaggaac gtcggcatct cgatctccgc ctgtatcggc ggtagcggcg accgtcccag
     9661 aggtacggac gccgagcttc atggcgggtc agggcgaccc gcggaaccga gaaggaggaa
     9721 cacatggcga tcggaacgct ggagctgagc gcgaccggca gcgacgacga gttcgacctc
     9781 gacgtcagcc tgctggaggt ggcggacctc gccggtctgg tcaacctgac cgacgacggc
     9841 tgcggcagca cctgcaccgc ctgcaccacc aacgtcgcct gatcaacggg ctccgcaagg
     9901 ccggccggcg ccgccacgaa tgtcggtgcc ggccgggcaa cccctgtctc gccgaggtga
     9961 tcatgtgagc cgatccgcgc agtctcccgc ctatagatcg atgagcacgg cgcttgtccg
    10021 cgccgtcgcc catccggcga tcgagctgcc cccgtggccg gacctgaccg aaccccgccc
    10081 cgagctcgtg acgtcctggg tcagctggct acggcaggtc tgggcaatcg atgccgtggc
    10141 cgaggcggtg acgctctcga gtccggtgct ggcggagcag gtcagcaagc tctgcgcgga
    10201 ggaatcccct tcggtacggg aggcgcggcg aacggtccac gccgttgccc ggtacgccca
    10261 gcgtctgctc ggtcgcccca cgccgttcgg tcttctcgcc ggcgtggcac ctgctgtgtt
    10321 cggctcgcgg gcacccaccc gctggggcac cgcccatcgg gccatcgccc gggcgggcgc
    10381 tggctggctc accgacgtga tcgcccaatt cgaacgctgc cccgagctgc tctcccgcct
    10441 ttcagtggtc gcgaacagca cgctgacggt ccgcgacgac cggctgatcg tcccctacca
    10501 gccacatcct ggaatcgacg ggcagctggg cgcggtggag gtctccctgc gccattcagc
    10561 accggtacgc gccgccatcg acgcggcgca cagcccgatc cgcgtggagg tcctcgcctc
    10621 gcaggtccgt gagacgtttc cacaggcgtc ggcggcagtc gtcatggcga tgctcaccca
    10681 gctgatcgcg cacggcgccc tcatcacgag cctgcacgct cccagtacgg agccagacgc
    10741 gctcgggcac ctgctgcgcc agctggatga ggtcggcgcc gggacagtta cgcccatcgc
    10801 tgatttcatg ggctcgctcc aggaagtcca tgccgggctg cagcgtcaca actccgcccc
    10861 gccgggggat gccccagcgg cccggcggct ggtcgcctct cggatgcgga gcctcgcgct
    10921 ctccgcgcac gagccgcttg cggtggatct ccgactggac gcctcggtga cgctccccga
    10981 ccaggtggcg acggaggtgg aacgcgccgc gctggtgctg acgcggttga gcgcgtaccc
    11041 atacggcact gccgcgtggc gggcctacca tcagcgattc tacgagcgtt acgggatcgg
    11101 gtcgctagtg ccggtgcggg aggtggtcga cccggacagc ggcattggtc tgccggacgg
    11161 ctacccgggc agccccgccg cggagcctcg ctccccgatc tcgcggcggg acgaggtact
    11221 gctgagcgtg gcacagcgtg cggcactgga cggcacgatg gaggtcgtcc tcgacgaggc
    11281 gctgatcgcg cagctggagc tgggcccaca gcggctgcgc ctacctccgc acctggaggc
    11341 atgcgtacgc gtacaggctg ccgacgagga ggacctcgcg cgcggcaggt tcaccctcga
    11401 ggtcacctcc gtgtcccggg ccgccggcgg gctgaccggc cggttcctca gtgtgctgcg
    11461 cctgaccgac gcgggcaggt tgggcgccgg cctaaccgac ctgcccgcca gtgaccggga
    11521 caccgtcgcc gctcaggtgt cgttcccccc gctggatccc ggcaccgcgc acgtcgcgcg
    11581 cgccgtccag gtgctaccga cggtgatcag cctggctgag caccggtggc cgagccgcgc
    11641 ggtgctcacc gtcggcgacc tggcggtggg gtgcgacggc cggcgcatgt acctcgcggt
    11701 cccggaccgc ggtcaccgga tcgaggcggt cggcctgcat gcgctgaacc tgcgaaccca
    11761 cacgccgccg ctggcccggt tcctcatcga actcgggcgc gcccagtgcg cccaggtgac
    11821 ggcattcgac tggggcaccg ccgctcgcgc gaagctgccc ttccttcccc gggtgcggta
    11881 cgggcgggcg atcctggccc cggcgacctg gcggctcgag gccgccgagc tgcccgacca
    11941 acaccaacct tggtacgcct gggacgacgc cctcgacgaa tggcgggctc gccggcgctt
    12001 accgcgcctg gtgcacctgg tcgaggccga ccggcgcctg cccctggatc tcgatgagtc
    12061 ggcgcaccgc gtcctgctgc gtacccacct gctcaccgca ccgcgagcgg tcctcgtgga
    12121 ggcaccagcc ccagagaacc tcggctggtg cggcggccgc ccgcatgagg tcatcgtggc
    12181 gctgcacgcc accgaaccac caccctggcc gccgctgccc acgccgaccc cggcccgcgt
    12241 catcggacgc gaccaggggc aggctccggc ctcatcccgg atcctgctcg cgaagctgta
    12301 cggagacatc cgccgccaag acctcctcct ggccgaacac ctcccgcggc tgatcgccca
    12361 gtgggacgcc ccgcccgact ggtggttcct ccgtttccgc gaccccgacc agcacctgcg
    12421 tctacgcatc gctctacccg acgtatccgc gtttggaccg gcagccgagc gcatcagcgc
    12481 gtgggccgac gacctgcacc ggcgtgggct gctgcgggag gtgcagtacg ccacctccta
    12541 cccggagacc gggcggtggg gatccggccc cgccatgcaa gccgccgagg cggtcttcat
    12601 cgccgactcc cactccgtcc tgacgcaact gcgccaaccc gttcggccca gccgacaggc
    12661 gctggtcgcc gcgcacaccg cggccatcgc cgtcgccttc accggcagcg tcgacgccgg
    12721 catgcgctgg ctggtcgacc acgtgcccgc cacggcaccc cagccggtcc cccggccgct
    12781 gttccgcgaa gccgtccacc tcgcccaccc cggcggcgac tgggcgacgc ttcgcgcggc
    12841 cgccggcggc accgccatcg tcgacgcctg gaagaaccgc gacgtagccc tcgccgtcta
    12901 ccggactcac ctgcccggcc cgcacaccga cggcatcgac gtcgacgacg tcctcggctc
    12961 gctgatgcac gcgcactaca ttcgcgcggt cggtatcgac ttcgacgacg aggaccagtg
    13021 ccgttacctc gcccgagccg ccgccctggc ctacttcgcc cggagtcggt catgagcctc
    13081 gcgtacgaaa gccacgagct ggccgtcgcg gtcgccgacc tcctcactca tcccaacgat
    13141 cccagcctgc cgatccacca accctggtgg cggcagtcgc tcgccctcgg cgtacccggc
    13201 atcgcgctgc tgcacgtgga gctggcagcg gcggggctaa gaccgtggca acgcgcccat
    13261 cactggctgg ccgccgctac cagcggcccg gtaacagcgg gcgccgacag ccaccccttc
    13321 catggcgcgc ccgcgctggc ccatgtcctc gcctgcgccg ccgcccacca acccggcacg
    13381 tacgcccggg cactcgacgg cctcgacacg gcgattgcag ccgacgcccg acgccgtgtg
    13441 cacgccgcgc acgcccgcat cgacgcccgc aagctaccgg ctctcgctga gttcgacgcg
    13501 atccgagggc tcaccggagt cggcgcgtac ctgctccgcc gagcgcccga cgggccggaa
    13561 ctgcgtgcgg tcttccagta cctggtccgg ctgacccagc ccctacaccc cgatggcgag
    13621 gttttaccgg gctggtggac cggtagcagc ccctccggac gcgccgacgc ccggttcccc
    13681 ggcggtcacg gcaacagcgg aatggcgcac ggcatcgccg ggcccatggc gctactggca
    13741 ctcgccgctc tgcacggcgt cgttgtcgac ggccagctca ccgccatctc gaccatctgc
    13801 gcctggctcg accgatggcg tagcgacacc gacggcggac ccatctggcc gtactggatc
    13861 accaggccgc agctgcgggc ggaccacgcg caggttctcc gcacccagcg cccgtcctgg
    13921 tgctacggca cggcaggcct ggcacgcgcc cagcagctcg ctgccctcgc gctgaacgat
    13981 cccgtccgtc gtgcggctgc cgatggcgca ctcgtctgcg ccctcgccga cctgcaccag
    14041 ctcgctgcga ccactgaccc ctctctctgc cacggctatg ccggcctggc ccacatcgct
    14101 caccgcgtcg ctgccgacgc actgcccgac gtcgcggagc atctccgtgc cctggtcccc
    14161 cgccttctcg accagatcgg tccgtcgggc gccgaccctc ggcgcacggc tgccgctctg
    14221 gtttccgacg cggcacgacc aggactactc gaaggcgctg ctggtgtcgc cctggccgcg
    14281 ctgagctgca gcaccgcagc gacggcgagc agttcctggg atgcctgcct gctcaccaac
    14341 cgacccgccc atcccctgac gtgaggacgt cgagccccat gcccacaccc gcctggcggc
    14401 agtacaccgt cgagttcccc accccatccg cagccgagga catcgccgcc tccgctttgg
    14461 cgcccgccct gaccgccgcg cagaacgacg gcgtcctgca cggatggtgg tacgtccgga
    14521 agtaccccac ctggcggtgg cggtacgtcg ccgacgaccc gacgtcgcac ctcgtcgaag
    14581 acctgctgga gacgctcgcc atcgaggacg gcatcatcaa ctggacccgc ggcgtctacg
    14641 aacccgagat gttggccttc ggcggtacgg ccggcatgca cgtggcccac gaactgttcc
    14701 accaggacag ccaccaccta ctgcttcgac ctgctgccgc tccaactgtg ctgggcaggc
    14761 gcgaatccgc cgtgctgctc tgcagcgtcc tcatgcgcag cgccggcctc gactggtacg
    14821 agcagggcga cgtctgggcg aaggtcaccg agctgcgtcc ctcccccgcc ataccagcag
    14881 aggaccaggc cgcctccctg acccggtcga tcaaccggct catgactgtc gacgcccgaa
    14941 gcctgagcca gcccgactcg ggcggcccac tgatgggcta cggcgcctgg ctcgacgcgt
    15001 tcgagaacgc cggccaagcc ttggctgacc tcgcgcggca gggccgcctc cgacgagggc
    15061 tgcgctcagt cctcgcccac cacgtcatct tccacgccaa ccgcatgggc ctgtccgtac
    15121 gagatcagtc caccctcgcc gcgctcgcgg tgaggaacgt cttccacacc accacgagga
    15181 gcaccatgtc gacctcagca cccacgcccc cgaccactag cgtcgaccgg gtgaccacgc
    15241 ttcgtgaacc caccgacctg cgaaccgagc tcaccgaccg gctgcgcgct gagaacgtca
    15301 tccgcacgcc cgcggtcgag gccgcgatgc gccggacccc gcggcacctg ttcctgcctg
    15361 gagtgcctct gcagcaggct tacgtcgacg gtcccgtcta caccaagacc gacggcagcg
    15421 gcacctccat cagcgccgcc tcgcagcccc ggattgtggc gatgatgctc gaacaactcg
    15481 acgcccagcc cggccatcga gtcctcgaag ccggcgcggg caccgggtac aacgcggccc
    15541 tcctggcagc catcgtcggt gacagcgggc gcgtcgtcac gatcgacgtc gacgacgacc
    15601 tcgtcgccgg agcccgcgag caccttgccg ccgccggcgt cgccaacgtc gaggtcgtcc
    15661 acggcgatgg tgcgctcggc caccccgacg gcgcacccta cgaccggatc atcgccaccg
    15721 tcggcgcctg ggaaacgccg accgcatggc tggagcaact tgcgccggac gggcgactgg
    15781 tcgtaccgct tcggctccgc ggcgccgcat cccgctcgat catcttcgaa cggcacgccg
    15841 gcggctggcg cgacaacggc agcgagcttg cggtcttcat gccgctgcgt ggcatcggcg
    15901 acgacgcccg ccgccttgtc gccctcagcc cggagcagga cgtgaccctg caggtgcaca
    15961 aagaccagga ggtcgacgcg gccgcactcg ccggcgtact ggacaccgag cggcaagaga
    16021 tgtggaccga cgtcctcttc ccaccgatgg tgccctacga gtggatggac ctctggctcg
    16081 cctgccgcct cgacaacgcc atcatgcgga tgaacgtccg acccgcgagc atcgagcgcg
    16141 gcaccgtcac cccgatgttt ccgtggggcg cgatggccac cacccgcggc gcggacctcg
    16201 cctacctcac catccgaccc gcgccgccgg ccgccgacgg ccgcaagatg tacgaggttg
    16261 gcgtcatcgg ccacgggccc ggcggaaaag acctcgccca gcacgtcagc gaggagatcc
    16321 gcacttggga cgcggactac cgctcccgca ccgtccgctt cgacatctcg gacgcgcccg
    16381 tcgaggcgga tccttcggcc ggacgcttcg tcctccccag ctcgcaccac cccatcaccg
    16441 tcacctggga gtgaccggtg gacccgaaca gcccgatcct ccggcggttt cccctcgtag
    16501 ccaggccacg gcccatcgcc aaagccctga ccgctcgcat cgatgacctg cgtaccctgg
    16561 ccaaccgcgc cgatcgggag gacgacatga ccgcagcgtc agccgtatac aaccgggcgg
    16621 ccctgatcgc ctcggactgc ggccagcccg agctggcccg gcagtggtgc cacgagcatg
    16681 ccgacgcgta cctgcgcgcc ttccccttgg gcacgcaggc cgcgcgtcat gccctggagc
    16741 ccttggtgaa cctcgcccgc ctgcacatca gaagcggcga cggagacgcc gctcttcggc
    16801 tcctcaccga cctctttcag gcggcctcat cccgcaccga cgcgctgatc gacggctact
    16861 ctctgctggc gagcagactg acccggactg cggaagacca tcgcgaggta cggcaatggc
    16921 tgtggagcgt gctcctcgcc gagggtgctc gcgcgctcac cagcgctgac cggtggaaag
    16981 aggcctacga ccacctccag cggcacaacg gcatcggccg gcggatgctg gacggacgcc
    17041 aggtcgcggt catcgcccac gcgaccgccg gcgagatcga gcacgcccgt acgctcgtcg
    17101 ccgagaccgc ctgcggcgag ccgtgggagc agagcgtcac cgcatgcctg gactacctgt
    17161 gcggcaaggc ggccggcgag gagaccttcc tcgacgcgtt gctcgacagc taccgacggc
    17221 taacgcccac acccagcctt gccgtcttcc acacccgcct cggactctcg atcatcgacg
    17281 cggctggcgg agtagcccat cccggggtac gaaacctggc tgcggagctg atcaaccagg
    17341 ccgtcgcctt cgatgacgcc cacgttgcac gtgacctgct ggaccacggc ggcatacgtg
    17401 cagtcgtcga tgcgcaaggc gaagctgagc tcgtcaccat cctgcatgcg ggtgggacgg
    17461 caggccgtcg gttgccgtgc gtcgctcacg agcgcctgtt ccagtccctg gctgtcagca
    17521 gagcggtgat ccaacggctg ccactcggcc aacacaggcg cgtgggcgcc gccagcgccg
    17581 agtcaggcag atgatcgagt cgctgcctgc ccaagtaggg tcgaccggtg accgcgtacg
    17641 agatcgccgc ccggctgcct accatcgacc tgctgcggcg gcgctgcaag gcgttggccg
    17701 tgctggaacg catcatcgac ggcggcgaac cctactacgg ctacacctcg gcatggggcg
    17761 cggacgaggc ggcgctgatg agcaacggca gcggcgacga gtgggccgcc gtgttcaccg
    17821 ccgacggcgc gttcatccgg gttttcgatc atgagtccgc gatgtcgccc taccgcgatc
    17881 cagaccacga gctgtggccg ggcctgctgg acggcatccc caaggtgttg cgtccgcagg
    17941 tggaagaacc cgctttctgc gatgaggccg ggcagttcat cgccaccgcg gtgctgtggc
    18001 ggctggccgg tgatgacgtc tggcacgccg gcgaaggcat caccttcccc ccggtgcagg
    18061 ggccgtacgc cgacaccggg ccggacgggt ccggcatgct cgacattctg ctcgacgaca
    18121 tcgtcgaccg gttcgtcgag ttcgccagcg actactacga gatcgaggtg gaccgggcgg
    18181 cagtcgagca cgtcgtcgcc caccggccac tgaccgacac cgtgatacag gccctgaacc
    18241 ctcgactcac cgtggccgac ctccgggagg acatcgccgc catctacccg atcgcttcga
    18301 tgtagcggga ggctcggcaa gccgctcgcc gagcgccagc gtacgtctgt cacggaccag
    18361 gacactcccc ccgggacgcc ccggcgcacg attcggttgg ttggcgcggg ggcgatgact
    18421 gccgtcgccg cgaaggactt gccatagtgc ttcttgtcga tatgccttac ggtgctgatc
    18481 gtgaagttgc gccgggtaac cgttgcggga ctggttgctg ccggcgttgc tgcggtgacc
    18541 ctgatgatcg gcctggtgac caacgccgcc tccaatcagc agcggtggcc cggctggttg
    18601 tctctggtgc agcggtaccc gtggcagtcg ttcctgttgc ttgcggtcgt tgccgtggtc
    18661 ctcgccgcat tgctgccggg cctgaccgac cccggccagg tcggtatgcg gatagctgac
    18721 gatgagccca cgccctcggt gggagcggcc gcggtcttgc gtaccctgcc gcgcgacgtc
    18781 gccggcttca ccaaccggcg ggacgagatc gagcagatcc tgaacgatgc gtcgcatgat
    18841 cagttaatcg tgccggtccg gaccatcgac ggcatggctg gcgtcggcaa gaccgccttt
    18901 gccatccacg tcggccatct gctggcgccg aagttcccgg acggtcagct gttcctgaac
    18961 ctcaacgggc acacgcccgg acgtgggccg gtcgggccgg ccgaggcgct cgcgtcgctg
    19021 ctgctcgccg acggcgtcgc cccgcagaag atcccaaaca gcgacgacca gtgggcgatg
    19081 accgaggctc gcgccgcaat gtggcgcacc cgggttgctg atcggcggat gctgctcatc
    19141 ctcgacaacg ccgccacgta cgcgcaggtg gagcagctac tgccgggcgc ggccggcagt
    19201 ctcgtgttgg tcaccagccg tcgccggcta gccgcaccag acgcgacgag tctgcagatg
    19261 agcgcattgt ccgcgacgga cgccgccgca ttgttcatgc gtctggccgg tcgtagccgg
    19321 ctcagcaagg aatcggtcgg tgagctcgtc gctgtctgcg gttaccttcc gttggcggtt
    19381 gccttacttg cggcgaggct acggcaccat ccgtcctgga ccgtcgagaa cctcaaggat
    19441 cgcctgctgt cgacgcagca ccgcctggtg gagatgcagg cgggcgagcg cgccgtcgcg
    19501 gccgcattcg acctgtcgta ccaggaccta ccagttgaac gtcagcggtt cttccgtcga
    19561 ctcagccggt tcccggggct cgacgtcgat gaagaggccg cggcggcgct ggcttcggtc
    19621 tcctgggcgg tggcgcgagc cgagcttgag gcgctgtacg gggatcacct gctggatgaa
    19681 accgagcacg gacgataccg gttccatgac ctggtcaggg actatggacg cagcctcggg
    19741 gaagacgggc aggacgggac gatgtcgatc aagaacctcg cgggacacta cctggagacc
    19801 atcggcgcgg cgaacaccta catcagccgc ggatccacga ccactacggc ccgattcgat
    19861 tcgctggcca cggcctcggc gtggcttgac gctgagcgcg cgaacgttct ggcctgcgtc
    19921 gaggagtgtg tgcgtcgcga gcagcatgcc ctggtcgtgg gactcgccgc cgcgatggcg
    19981 ccgtacctgc gccaggcggg tccgtgggac caggccgccg aactgcaccg caccgcggtc
    20041 gtggcggcac gccgcacggg tgaccggaag gcagaggccg acgcgttggc gaacctcggc
    20101 atggtatccc gcctcatggc ccggtaccgg gcggcggtgg agacgctgaa cgagtcgctc
    20161 gcgatctacc tggctctcgg cgatctggat gggcaggcgt taggtcccgt ctggagttgt
    20221 gatcacggcg gtgtggaggc cggccggtcg gccgctccat gctggtagaa cggtggcgtg
    20281 acacgccgcg agctgagtga cgacgagtgg gcgttggttg aaccgttcct gccgatcgag
    20341 gcctacggtc cctatccgca gcggttgcgg gaccagttcg agggcgtgat ctggcggttt
    20401 cgtaccggca gccaatggcg ggagatgccc acggagttcg gggcctggca gacggtctac
    20461 gaccggttca cccagtggcg cgacgctggg gtgttcgccg ccttgatgga ggggatgatc
    20521 gctgaggccg cccggcgtga ccaggccgac ctgtcgctgg tcagcgtgga ctccacggtg
    20581 gcgcgggcgc atcacgatgc ggccgggatg gtcgttgaca cggcggtgct ggcggccctg
    20641 gagcaggccg cgggggcgaa aagggggatc ctggatgcgg gcaaaccgcc ccagtgaccg
    20701 tcgaggacca ggcccgggcg gcggtacggg ccgagcgtcg ccggttgcta cggcgccatc
    20761 gtgcccggct ggcggcggcc gggttggggc gctcacgtgg tggattgacc agcaaggtgc
    20821 acctggccgc cgaccgtcgc cgtcggccct tggccttcgt cctcaccccg gggcaggccg
    20881 ccgacagtcc ccggttcgag gcggtgttgg aacgggtgcg ggtgcgccga ccggtgggac
    20941 ggccacggac ccggccggag gcggtggctg ccgataaggc gtactcgtcg cgcgccaacc
    21001 gcgcctacct gcgtcgacgc aggatcaagg cggtgatccc ggaaaaggcc gaccagatcg
    21061 cccaccgtcg caagcgcggc agcgggggtg ggcggccggt ttccttcgac gccgagctgt
    21121 accgggagcg caacacggtg gagcggtgca tcaacaagat caaggcgtgg cggggcctgg
    21181 ccacccgcta tgacaagacg cccgacagct atatggcagg gctccagcta cgcgggacgc
    21241 tgatctggct ccgcagcctt caacccatca cctgaaccaa gctccaaata ggacctaggc
    21301 gacgatcggc gccggggcct ggagtacgag ttggcgcagc gcggccaggc ggccggggag
    21361 cgtcgggaca ccgaggtccc ggatgagcgg gcgatcgtgt cgagggtgag gggtcggcct
    21421 ggttggctgg agccaggctg tgtgtggttt catcccgtgt cgcgctgaca cagcacgcgg
    21481 tcgggcgtga ggatgtgggc atgagttcat cgcagcccgt cgtcgacccc gggcccgagc
    21541 cggacacgac cgcgggcggg ccggtgaata ctgctgacgc gcggtccagg cccccatcgc
    21601 cggacgcccc cgagtcttcc ccggatcacc gctacctgct cgacaacgcc cgggtggagg
    21661 cgggcgagcg gttcacctgg ctggccgagc tgttcgacgg tgtcacgcgt gggcacttcg
    21721 accgtctcgg agtgagggcg ggctggcgct gctgggaagt tggtgccgga ggccccagca
    21781 ttcccgaggc actcgccacg gccgtcggac caaccggtta cgtgctggcc acggacatca
    21841 atccggcctg gttggacccg cacggcgggt acgaggtgct ccggcacgac atcgtcgggg
    21901 acccgccgcc gcagccaggc acgtttgacc tggtacacgc gcggctcgtg ctcgttcacg
    21961 tgcccgaccg tgcccgggcg ttggcgacga tggtggcggc gctgcggccc ggcggttggc
    22021 tattggtgga ggatgccgac accgagctgc agccgctggc ctgcctcgat gaggttggcc
    22081 cggcgcagcg gcgcgccaac cggctgcggc gcgccgtccg ggagttgatg acccgccgcg
    22141 gcgccgatct gcgctacggc cgtacgctgc cgcgggcgtt gcgtgcggcg ggcctagtcg
    22201 atgtcacggc ggccggctgc ttcccggtcg gcggggtagc ctgcgaccgg ctggagaccg
    22261 cgacggtgcg catgctccgc gccgagttgc tcgccgcagg gctggccaac gaggtcgaga
    22321 tcgacgcgca cctggccgcc gtcgatgccg gcgagctcga cctcaccctc gcgccgctga
    22381 tctcggcatg gggacgccgc ccaggctaag cagtctgcct gaagttccgc atgtaactgg
    22441 gtggcagcat ggagcgccga ccggccggcc tccacaccac cgtgatcaca actccagacg
    22501 ggacctagtg ctcaaccagc tcggcattgt gcactacctg accgcgacgt acgacgaggc
    22561 ggcccgagct cagacggaag cgttggggat ctgccgggag aacggtgacc tgctcggcca
    22621 ggcgaacgcg ctcgccgacc tgggcatggt gcggcggatg accggtgacc tggggccttc
    22681 cgccgaagct tcgacggaag cgctggagat ctaccggcag ctcggtgatc gttacggcga
    22741 ggccaacgca ctccgcgacc tcggactggt ccggtccctg accggtgact acgccgagtc
    22801 cgagcacaac gcccgcgagg cgctggcgat ctacaccagc atcggcgacc cggtgcacca
    22861 ggcgtatgcg ctcaacgagc tgggcgtcgc ccgtcgtctg cagggggacc tcgaaggggc
    22921 gaccgaatcg cacgaacagg cgctggccaa gtacatcgag ctaggtgatc gattcggcga
    22981 ggccaatgcc atccggcacc tcggggtgct gcaccggctt cgaggagacc aggcagcggc
    23041 ggtcgaggcc caggagcggg ccgtgaccat ctatgccgaa ttggagagcc ggggcgggat
    23101 ggccgccgcc acggccgagc tgggcgtcct gcgacgtctc gacggcaacc tcgtcggcgc
    23161 caggagcgcg ttggacagcg ctgcggcgtg gtacgccgag ctcggagacc gcaccggtca
    23221 gctcgaagtg cataaccaca tcggcgcgtt gcacctcgac gccgttgaac tcgaccgggc
    23281 gagtaaccga tacgagctcg cactgtccct ggcccgcgaa ctgggggtgc cgctgcagga
    23341 agcgcatgcc ctggagggcc tcgcccgctg cgaacttgct ctggggcgac ccgagcaagc
    23401 ggccgacctc cgcagcgccg ccaagatgct ccatgaacgg ctcggaaatc ggcatacgta
    23461 acttcactcc gtcccggtat cgtcaccgta agacatgaag gaggcggcca tgcagcagtc
    23521 gacgacgtcg aacgtgcagc ccgtgctggc gacggtggtc aagagggtcc acgcccggat
    23581 cgcggccgag caggtcaagc ccgaggccgt tcgagccgca cacgcggcgt cgattcccgc
    23641 gcaatcctga gcagccgcgg cgcgcgggca tgccaccact gcgaaccttc atcctcaagg
    23701 tggtcaaccg ctgcaacatc aactgcgact actgctatgt cttcaacggg ccagaccagt
    23761 cctggcgtgg cctgcccgta cggatgagcg ccgaggtggc ccacgccgcc gcgcagcgaa
    23821 tctccgagca tgccactgcg cacgacctcg accacgtgga cgccgtgctg catggtggcg
    23881 agcccctcct cgccgggccg cgccacctcg gcgccatcct gcagatcctt cacgaccgag
    23941 taccgtccgt ccgcttcgag ttacagacca acggcatgct gctcaacgac gactggctgg
    24001 atctctttga acagttcggc gttcgggtcg gcgtgagcct cgacggccgg ccggtggcga
    24061 atgaccgcca ccgtgtcagc caccgcggcc ggtcaacgtc gtacgccgcg gtccgcggca
    24121 tcgaactgct ccgtagccgg cccagggccc cggcaaagtc gtcaggtgat gccgagtagg
    24181 gccagtggtc ggttgctgtc gcgggcgtgg tggcggttgc cggcggcgat gttggtgacg
    24241 ccggcctggc gtagggcgcc gatggcggcg ttgcgtaggg ctgccatgac ctggggtccg
    24301 gtgccggtac ggatctggga tcggtcttcg tcgtaggtca cgtcgcggac ccagtggact
    24361 ctgttctcga tcgaccagtg accgcggatc cacgaggcga gctgcgccgg cctggcctgg
    24421 tgaacgagca ggtcggtgat cgcgtagacg gtctcggtgg tgaagcgttt cggctggtcg
    24481 agccggcgtc gacgccgtcg gatctgcaac gcctgggcgg cgtggggaaa atcgatcccg
    24541 gtggagacgg acaggatctt cagggtgcgg atctcccggc ggccatggcc gcggcaggtg
    24601 tcacggtcgg cgtcaggcac ggcccgccag ggcagagcgg ccaactggtg gtgcaggctg
    24661 ggctggttgc ccttcaccgt gaggatccag tgggcgccgc gctcggcgag gtaggcgacg
    24721 tgctcacgtt ggcaatgcaa cgcgtcggcg gtcacgacca cgccgtgcag gtctgggatc
    24781 tggtcgagca ggggtgcgaa gcgggtgatt tcgttggtct taccgttgac gtcggtgctg
    24841 gccagcacga caccactggc ctggtcggcg gcggcgagga cgtgccgggc ggtcgtgtcg
    24901 ccggtgcggg aaccgcggat cgtcttgcca tccacggcga tcgccctgct cgaccctgcc
    24961 ggcgctgcgg gagtgcatcc ggccagccag gtcccgatca cgacggcgag cacctcgggg
    25021 tccagggcct gcagcagtcg gcggatcatg gcctcggacg gccggcggct tgcgtcgatc
    25081 ccgagcagga cggcggtatc ggcgggcagg tcagcgaccc actccccgat cgccgtgtag
    25141 gagcggtaac cggccacgac cgcgcagacc gccgcggcga ccacggtcac cagacggtgc
    25201 cgtactccac ggcgggcgcg aggatcgggc agatccgcca acgccgtgag cagcccaccc
    25261 gcaccatcct ccacagaggt cccggccggt gcggttgaca acgatgagat cagcgatgat
    25321 ggcaacgcgg gcatgactca cttcagatag atcaacaggc ctcgagaacc tcgatgatct
    25381 tccggagcgg tcatgcccgc cttgctaccc acacccaggg cgcgtctgca ccaaccacct
    25441 caagccggac acccctcacg actttgccgg agccctggta gccggcccca cctgttcgcc
    25501 ggcgtcctgg ccgtggtcga cctccacaat gacccagccg aggttcacga ctatctcgcg
    25561 tcactgggac cggcggtcat tgacttcaac ctgccccacg ccacgcacga cgccccaccg
    25621 gagcgcgccg atcccactga gccggagtac ggcaggtggt tgagccgcgt ctacgacgca
    25681 tggaccggcg ccagttccta cacgcactcg gtgcgcatac tggaagacat cgtggctctc
    25741 agcctcggcg tgaagggctc cgtcgaatcg ctcggactcg caccggccga catcgtcgtg
    25801 gtcgagtccg acggctcgat cgagaacgtc gacacgctca aagccgccgc cccgggcgcc
    25861 gcagatctcg gcctcaacgt cttcgaccac accttcgacg aggtggccaa ccaccctgcg
    25921 attcggcaac ggcgggccgg cgtggcggcc ttggcgcagg agtgccagcg ctgcccactg
    25981 gtgtccgtct gtggcggcgg atatctgccg catcggttga gcgccgagcg cggataccgc
    26041 aacccgtccg tctactgtca ggacctcgcc cacctcatcc ggcacgtcca agccacgctt
    26101 ccggcctgaa ggagaagcac agtgcagcac ctcgtcgtcc gccacgccga gcccggtgac
    26161 gccaagaccg tcgccgcgat gatcgaggag atcgagcggt actacggcgc cacatcgatc
    26221 cagccgttcg gggagcggct ggcacaggtc gaagccgcgc tgttcgggac gccgccgctg
    26281 gcgtactgcg tgctcgcgat cgccgaagac gacctggtgg ggttggcggc gtactccttt
    26341 ctgtggccgg cggccggatc gacgcactca ctgttcgtca aggagctgta cgtgcggccg
    26401 gacggacggc ggctgggcac tggaacgcgg ctcatgcggg agatgcaagc aatt
//
