LOCUS       NZ_FMHJ01000010        11273 bp    DNA     linear   CON 28-JUL-2024
DEFINITION  Streptomyces sp. WMMB 714, whole genome shotgun sequence.
ACCESSION   NZ_FMHJ01000010
VERSION     NZ_FMHJ01000010.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces sp. WMMB 714
  ORGANISM  Streptomyces sp. WMMB 714
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Varghese,Neha. and Submissions,Spin.
  TITLE     Direct Submission
  JOURNAL   Submitted (16-JUN-2016) DOE - JOINT GENOME INSTITUTE, 2800 Mitchell
            Drive, Walnut Creek, CA 94598, USA
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_900090125.1-RS_2024_07_28
            Annotation Date                   :: 07/28/2024 02:17:28
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,656
            CDSs (total)                      :: 5,578
            Genes (coding)                    :: 5,496
            CDSs (with protein)               :: 5,496
            Genes (RNA)                       :: 78
            rRNAs                             :: 6, 5, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 6 (5S)
            partial rRNAs                     :: 5, 4 (16S, 23S)
            tRNAs                             :: 60
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 82
            CDSs (without protein)            :: 82
            Pseudo Genes (ambiguous residues) :: 0 of 82
            Pseudo Genes (frameshifted)       :: 15 of 82
            Pseudo Genes (incomplete)         :: 72 of 82
            Pseudo Genes (internal stop)      :: 4 of 82
            Pseudo Genes (multiple problems)  :: 8 of 82
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 06:07:12
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 45437
            Orig. end                         :: 56710
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            FMHJ01000010.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..11273
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="1"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..11273
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..11273
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:6273](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..6273)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     misc_feature    complement(421..436)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 19.5"
                     /tool="antismash"
     gene            892..2364
                     /gene="hemG"
                     /locus_tag="H181DRAFT_RS18750"
                     /old_locus_tag="H181DRAFT_03782"
     CDS             892..2364
                     /EC_number="1.3.3.4"
                     /GO_function="GO:0004729 - oxygen-dependent
                     protoporphyrinogen oxidase activity [Evidence IEA]"
                     /GO_process="GO:0006779 - porphyrin-containing compound
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="hemG"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1222: dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019547462.1"
                     /locus_tag="H181DRAFT_RS18750"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="H181DRAFT_03782"
                     /product="protoporphyrinogen oxidase"
                     /protein_id="WP_045865705.1"
                     /transl_table=11
                     /translation="MHVIVIGGGVSGLAAAHRLLAGGASVTLLEASPRLGGKLLTGEVA
                     GTAVDLGAESMLARRPEAVRLAREAGLGDALQPPAVAGAAVWSRGEMCAMPKGHVMGVP
                     GEPEALSGLLSDAGRARVAEDARLPATEVGEDVAIGEYVAARVGREVVDRLVEPLLGGV
                     YAGDAYRISMRAAVPQLYEAARGEPSLLAAVRGLLRAQAETQGRAETQGRAQGRAETQS
                     AAGAAAGAPVFMGVEGGVGRLPGAVARVCRDAGAEIRTGVAVRTVRGPRTGARSGREVV
                     TEAGEVLAADAVVLAVPAPRAAAVLADEVPAAAAELNAVEYASMALVTMAFRRADIGVP
                     PPGSGFLVPPVDGRTIKASTFSSNKWGWVAASSPGLFVLRTSVGRYGEERVLERDDADL
                     VELSLHDLREATGLSAAPVDSVVTRWDGGLPQYPVGHMERVERVRRAVGETGGLAVCGA
                     VYEGVGIPACVGSGVRAAEQTLARAVPEDERE"
     gene            2370..3086
                     /gene="hemQ"
                     /locus_tag="H181DRAFT_RS18755"
                     /old_locus_tag="H181DRAFT_03783"
     CDS             2370..3086
                     /EC_number="1.3.98.5"
                     /codon_start=1
                     /gene="hemQ"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019358855.1"
                     /locus_tag="H181DRAFT_RS18755"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="H181DRAFT_03783"
                     /product="hydrogen peroxide-dependent heme synthase"
                     /protein_id="WP_045865706.1"
                     /transl_table=11
                     /translation="MTAAPDKAPNAGKKAKDLNEIIRYTLWSVFRLRDVLPEDRTGYAD
                     EVEELFGQLAAKDVTVRGTYDVSGLRADADVMIWWHAESSDALQEAYNRFRRTRLGRAL
                     EPVWSNMALHRPAEFNKSHVPAFVAGEEPRAYVSVYPFVRSYEWYLLPDEDRRRMLADH
                     GKMARGFPDVRANTVPSFSLGDYEWILAFEADELHRIVDLMRHLRGSEARMHVREEVPF
                     YTGRRKPVAELVAGLV"
     gene            complement(3109..4704)
                     /locus_tag="H181DRAFT_RS18760"
                     /old_locus_tag="H181DRAFT_03784"
     CDS             complement(3109..4704)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Abhydrolase_1 (105-292). E-value:
                     1.6e-16. Score: 52.6. Matches aSDomain:
                     nrpspksdomains_H181DRAFT_RS18760_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016824197.1"
                     /locus_tag="H181DRAFT_RS18760"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="H181DRAFT_03784"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_045865707.1"
                     /sec_met_domain="PF00561 (E-value: 3.3e-24, bitscore: 79.7,
                     seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRSVALHGALSALVLTAAAVVPSGSAPEVVPFPLRDAREKAGTAS
                     AASAAAAAGIDWTECPAAEQLPAPVECGKVTVPVDYARPAGEKIRLTVSRRGATGPARQ
                     GALLYNPGGPGGNGMSFPMYAAPFGDPVWRKLNKAYDFVGYAPRGVGRSAPLKCGERAG
                     RAAARPARSPRDPSAAYKRAMRRKAAAYATACAARAGDRLDHFTTPDNARDLEVLRAAL
                     GSGKLNFVGTSYGSYLGAVYATLFPGRVRRLVLDSVVDPRPGRVWYRSDLEQNIAFERR
                     WLDWKRWVARNHSVYRLGRTPRAVQREFDKVRTTLDARRVGGSAGRDLGSRQLLADYVR
                     VGYDAGTWPRHAAALSAFRHGDPRPLVAEAAPDRHGAAARANSDAVHNAVKCSDAPWPR
                     DFARWDRDSTAVARKAPFQTWENTWTNLPCAYWHGKRSRPVDVGARPGALPPVLLLAAT
                     RDPATPYEGAVRTWQRLPGSSLVTERGAGTHGVAGGNACVDRRLTAYLLHGRTPGRAAE
                     CAARPVPRPLPDGS"
     aSDomain        complement(3829..4389)
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_H181DRAFT_RS18760_Abhydrolase_1.
                     1"
                     /evalue="1.60E-16"
                     /label="H181DRAFT_RS18760_Abhydrolase_1.1"
                     /locus_tag="H181DRAFT_RS18760"
                     /protein_end="292"
                     /protein_start="105"
                     /score="52.6"
                     /tool="antismash"
                     /translation="ALLYNPGGPGGNGMSFPMYAAPFGDPVWRKLNKAYDFVGYAPRGV
                     GRSAPLKCGERAGRAAARPARSPRDPSAAYKRAMRRKAAAYATACAARAGDRLDHFTTP
                     DNARDLEVLRAALGSGKLNFVGTSYGSYLGAVYATLFPGRVRRLVLDSVVDPRPGRVWY
                     RSDLEQNIAFERRWLDWKRWVARN"
     misc_feature    complement(4787..4802)
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: weak,
                     score: 16.79"
                     /tool="antismash"
     gene            complement(5001..6273)
                     /locus_tag="H181DRAFT_RS18765"
                     /old_locus_tag="H181DRAFT_03786"
                     /pseudo=""
     CDS             complement(5001..6273)
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: DUF692"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018564414.1"
                     /locus_tag="H181DRAFT_RS18765"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="H181DRAFT_03786"
                     /product="DUF692 family multinuclear iron-containing
                     protein"
                     /pseudo=""
                     /sec_met_domain="DUF692 (E-value: 4.5e-92, bitscore: 301.9,
                     seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGWRPEIADGIEALPGIDWVEVVAENVCPDHLPEPLLRLSERGTK
                     IVPHGVSLGLGGADRPDRAKLAALAERAEALQAPLVTEHIAFVRAGGGATGRPRMEAGH
                     LLPVPRTRDALDVLCENVAAAQEALPVPLAVENIAALVNWPGEEMSEGRFLAELVERTG
                     VQLLIDVANLHTNHVNRGEDPAVALGELPLDALAYVHVAGGFERDGVWHDSHGHPVPRP
                     VLDVLAQLCARTAPPGVLLERDENFPPVAELAAELDGIRAVLAGSGAGAEARHG"
     gene            complement(6558..7295)
                     /locus_tag="H181DRAFT_RS18770"
                     /old_locus_tag="H181DRAFT_03787"
     CDS             complement(6558..7295)
                     /EC_number="3.1.1.29"
                     /GO_function="GO:0004045 - aminoacyl-tRNA hydrolase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018536944.1"
                     /locus_tag="H181DRAFT_RS18770"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="H181DRAFT_03787"
                     /product="aminoacyl-tRNA hydrolase"
                     /protein_id="WP_254666906.1"
                     /transl_table=11
                     /translation="MIDAQDAQKAADYALPLVVRLERDAPPALTDALETAARAVLTLLA
                     DERSAPGRDFAEPGTAEGEPGTAGAGEWAEAVRRWEQRDIRKVVRRARGAEWRRAQALP
                     GITVTGGTASVRVFPPVPVDGWPKDLSRLQVSGTVLDDAHPPARPVAGTAVLWMAPGLE
                     MSAGKAMAQAAHGAQLAWWRLPSEDRAAWAATGFALAVRRAPDRAEWERLVRSGLPVVQ
                     DAGHTEIAPGTCTVVADHPALDR"
     gene            7354..8199
                     /locus_tag="H181DRAFT_RS28900"
                     /old_locus_tag="H181DRAFT_03788"
     CDS             7354..8199
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007267204.1"
                     /locus_tag="H181DRAFT_RS28900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="H181DRAFT_03788"
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="WP_045865709.1"
                     /transl_table=11
                     /translation="MRLDGVGRRYGWRGDWVLREVDLSLPERSLVRFEGDNGSGKSTLL
                     RMLAGVETPTEGQITGRPSCGYVPERFPAAMPLTTRGYLTHLGRVHGLSRTVAVRRAGE
                     WLERFGAAGHSDTPLSELSKGTSQKVAVTQALMARPGLLVLDEAWTGLDHDARTVLDHA
                     VAERVAEGATVVFVDHDPGRLAGASDATYRIEGGRLRPVAEKDGPRRPGRAAGGGKRVR
                     VVAEGPPGQPPPALPASVIAEQLPGGTIILTAPVAYSDVLLGSLLEQNWYIRSVREESA
                     "
     gene            8196..8864
                     /locus_tag="H181DRAFT_RS28905"
                     /old_locus_tag="H181DRAFT_03789"
     CDS             8196..8864
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018088894.1"
                     /locus_tag="H181DRAFT_RS28905"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="H181DRAFT_03789"
                     /product="hypothetical protein"
                     /protein_id="WP_045865710.1"
                     /transl_table=11
                     /translation="MSALLGYHTALLMRSQRWLPPMLLYAAVMGIGVQWGQPVLDGLGY
                     AAAGLLPVTAWVVRICLNIEPLAARQCTAAAAGPARVHLAGVLAALLLTCALGAVGAVY
                     VVAVSDPRSSAGHVAVPLLPAVEAGLLAAFTCAFFGAAIGALCNRPLLSNSGVAVPSSL
                     LAVLLVLVVGGSPANAAVAGLVSASHEGAVTLPWLPAVASVAVAALATWLACSQAGRRG
                     "
     misc_feature    9152..9172
                     /note="TFBS match to MntR, Manganese transport regulator,
                     confidence: weak, score: 19.32"
                     /tool="antismash"
     gene            9168..9692
                     /locus_tag="H181DRAFT_RS18785"
                     /old_locus_tag="H181DRAFT_03790"
     CDS             9168..9692
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0051536 - iron-sulfur cluster binding
                     [Evidence IEA]"
                     /GO_function="GO:0051537 - 2 iron, 2 sulfur cluster binding
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004943248.1"
                     /locus_tag="H181DRAFT_RS18785"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="H181DRAFT_03790"
                     /product="(2Fe-2S)-binding protein"
                     /protein_id="WP_107068799.1"
                     /transl_table=11
                     /translation="MAKALSRQRRAPAVPDMPVELSVNGRRYKLHLDTRVTLLDALRDH
                     LGLTGTKKGCDQGACGACTVHADGRRVLSCLTLAAQCEDREITTIEGLGPSEEPHPLQE
                     SFVRHDGFQCGFCTPGQIMSAAALLAEGRAGSDADIREFMSGNLCRCGAYANIVAAIRD
                     VASAGGADASL"
     gene            9679..10668
                     /locus_tag="H181DRAFT_RS18790"
                     /old_locus_tag="H181DRAFT_03791"
     CDS             9679..10668
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018562342.1"
                     /locus_tag="H181DRAFT_RS18790"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="H181DRAFT_03791"
                     /product="xanthine dehydrogenase family protein subunit M"
                     /protein_id="WP_045865711.1"
                     /transl_table=11
                     /translation="MRPFDYVRAADVDEAVNLLAADPAASYLAGGTTQLDLMKDGVLGP
                     ERLVDITRLPLRGITRSDDALHVGALTTMEELAADTTVERSLPLVRQALLLGASTQLRN
                     MATVGGNLLQRARCRYFRDPAVPECNKRDPGSGCAAVENTARMHAILGVSDRCIAVHAS
                     DLAVALVALDATVHLQGMPGRRSVPLTQFYRESGASPDVENVLVHGELITGVTVPLPPA
                     SAASCYLKVRDRASYEFALASAGVVLVTREGTVEHARVALGGVASKPWRCLEAEQVLTG
                     SPATEETFREAAAASVQGAWTVPGTEFKVELAQRTLVRALRTVSGVTP"
ORIGIN
        1 aggcccagta cgaccacgtc cgcggggtag gtcttctccc cggcggcgac ggcgcgggcg
       61 cgtccctccc cgtcggtctc gaccgcggtg acctcggcgc ccgtgacgac ctccatgccc
      121 atcccgcaca tcgcgtcgcg caccagtgcg cccatgtccg ggtcgagagt ggtcatcggc
      181 tgttcggcct ggtccaggac cgtgacctcg tagccccgca gagtcagcgc ctcggccatc
      241 tccacaccga tgtagcccgc gccgacgacg acggcccggc gccgctcgcc gccggacccg
      301 gactccacgc cgccgagggt gccgagcagg gcctcgccgt cctccagggt ctgcacggcg
      361 tgcacgcccg gggcgtcgat gccggggagc ggcggacgca gcggggtggc tcccgtggcg
      421 acgaccagtt cgtcgaaacc ggtccatgtc tcaccgccgt cccccgacag gccgcgggcg
      481 cgcacccgtc cgccgtccac gtcgatccgc gtgacctcgg tgcgcatgcg caggtcgatg
      541 ccgcgttcgc ggtgcgcttc gggcgtacgg gcgatgaggt cgtcccgcgc gtccaccgat
      601 ccgccgatcc agtacgggat gccgcacgcc gagtacgagg tgaagtcgcc gcgctcgaac
      661 gcgatgatct ccagctcgtc cgggcccttg agcctgcggg cctgggaagc ggccgacatc
      721 cccgccgcgt cacctccgac gacgaccatc cggcgtgcag cggccatggt gcgtgctccc
      781 tccgtctcgt gggcgtgggc gcgggcggga cccgtgccgg cgtgaagccg ggtgccccgg
      841 tacgccggtc cccactgcct tgccggtcgt accccgtgca acagtttccg catgcatgtg
      901 atcgtgatcg gcggcggcgt ctccgggctc gccgcggcgc accggctgct cgccggcggt
      961 gcgtccgtga ccctgctgga ggcttcgccg cggctcggcg ggaagctcct gaccggggag
     1021 gtggccggga cggccgtcga cctgggcgcc gagtcgatgc tcgcccgcag gcccgaggcg
     1081 gtgcggctgg cgcgggaggc agggctgggc gacgcgttgc agccgccggc ggtcgcgggc
     1141 gccgccgtct ggtcgcgggg cgagatgtgc gccatgccga aggggcacgt gatgggcgtg
     1201 ccgggcgaac cggaggcgct gagcggtctg ctctccgacg ccggccgcgc ccgcgtcgcc
     1261 gaggacgccc ggctgccggc gacggaggtc ggcgaggacg tcgccatcgg cgagtacgtc
     1321 gccgcccgtg tgggccgcga ggtcgtggac cggctggtcg agccgctgct gggcggggtg
     1381 tacgcgggag acgcgtaccg catctccatg cgtgccgcgg tgccgcagct gtacgaggcg
     1441 gcgcgcggcg agccctcgct gctggcggcc gtacgcggac tgctccgggc ccaggcagag
     1501 acacagggcc gggcagagac acagggccgg gcgcagggcc gggcagagac acagagtgct
     1561 gccggtgctg ccgcgggggc gccggtgttc atgggggtgg agggcggcgt ggggcgcctg
     1621 ccgggagccg tcgcccgggt ctgccgcgac gcgggcgccg agatccgcac cggcgttgcc
     1681 gtacgcacgg tccgcggccc ccggacgggc gcccgctccg gccgggaggt cgtcacggag
     1741 gccggtgagg tgctcgccgc cgacgccgtc gtgctcgcgg tgcccgcccc ccgggcggcg
     1801 gcggtcctcg cggacgaggt gcccgccgcg gctgccgagc tgaacgccgt cgagtacgcg
     1861 tcgatggccc tcgtgacgat ggcgttccgc cgcgcggaca tcggggtgcc gccgccgggc
     1921 agcggcttcc tcgtgcctcc cgtcgacggg cgcaccatca aggcgtcgac cttctccagc
     1981 aacaagtggg gctgggtcgc cgcaagcagc cccggactgt tcgtgctgcg gacctccgtg
     2041 ggccggtacg gcgaggagcg ggtcctcgag cgggacgacg cggacctcgt cgaactgtcc
     2101 ctgcacgacc tgcgggaggc gacggggctc tcggccgccc ccgtcgacag cgtggtcacc
     2161 cgctgggacg gcggtctgcc gcagtacccc gtcggccaca tggagcgggt ggagcgcgtc
     2221 cgccgtgccg tcggggagac cggcggtctg gcggtgtgcg gagccgtgta cgagggcgtc
     2281 ggcatccccg cctgcgtcgg cagcggcgtg cgggccgccg agcagaccct cgcgcgggcc
     2341 gtgccggagg acgagcgaga ataggccgca tgactgctgc accggacaag gcgcccaacg
     2401 cgggcaagaa ggccaaggac ctcaacgaga tcatccgcta caccctgtgg tcggtcttcc
     2461 ggctgcggga cgtgcttccc gaggaccgca ccggatacgc ggacgaggtg gaggagctgt
     2521 tcggccagct cgccgcgaag gacgtcacag tgcgcggcac ctacgacgtc tcggggctgc
     2581 gtgccgacgc ggacgtcatg atctggtggc acgccgagtc ctccgacgcc ctccaggagg
     2641 cctacaaccg cttccggcgc acgcggctgg gccgcgccct ggaaccggtg tggtcgaaca
     2701 tggcgctgca ccgtcccgcc gagttcaaca agtcgcacgt cccggccttc gtggcggggg
     2761 aggagccccg ggcgtacgtg agcgtctacc cgttcgtgcg ctcctacgag tggtacctgc
     2821 tgcccgacga ggaccggcgg cggatgctcg ccgaccacgg caagatggcc cgcggcttcc
     2881 cggacgtgcg ggccaacacc gtgccgtcct tctcgctcgg cgactacgag tggatcctcg
     2941 cgttcgaggc cgacgaactg caccgcatcg tcgacctcat gcggcacctg cgcggttcgg
     3001 aggcgcggat gcacgtacgc gaggaggtgc ccttctacac gggacggcgg aagccggtcg
     3061 cggagctcgt ggccgggctg gtctgacggc tcacacggcc gctgccggtc agctcccgtc
     3121 cggcagcggc cgcggtaccg gacgggccgc gcactcggct gcccgtccgg gcgtcctgcc
     3181 gtgcagcaga tacgccgtca gtcggcggtc cacgcacgcg ttgcccccgg cgacgccgtg
     3241 cgtcccggcg ccgcgctcgg tgacgagcga cgagccgggc agccgctgcc aggtgcgcac
     3301 ggcgccctcg tagggagtgg cggggtcgcg ggtggcggcg agcagcagga cggggggaag
     3361 ggcgccgggc cgggctccca cgtccacggg ccgtgaccgc ttgccgtgcc agtacgcgca
     3421 gggcaggttc gtccaggtgt tctcccacgt ctggaacggc gccttgcggg cgactgccgt
     3481 actgtcccgg tcccagcgtg cgaagtcgcg cggccaaggg gcgtcggagc acttcaccgc
     3541 gttgtggacc gcgtcgctgt tggccctggc cgccgctccg tggcggtccg gggctgcctc
     3601 cgcgacgagg ggccgcgggt cgccgtggcg gaacgccgac agggcggccg cgtgccgggg
     3661 ccaggtcccg gcgtcgtagc cgacgcggac gtagtcggcg agcagttgcc tggagccgag
     3721 gtcgcgtccc gccgatccgc ccacgcgcct ggcgtcgagg gtggtgcgca ccttgtcgaa
     3781 ctcgcgctgc acggcacgcg gggtccggcc gaggcggtag acggagtggt tccgggccac
     3841 ccacctcttc cagtcgagcc agcggcgttc gaaggcgatg ttctgttcca ggtcggagcg
     3901 gtaccagacg cggccgggcc gggggtcgac gacgctgtcc aggacgaggc ggcgcacacg
     3961 gccggggaag agcgtcgcgt agacggcgcc caggtagctg ccgtacgagg tgccgacgaa
     4021 gttgagtttc ccgctgccca gcgcggcgcg caggacctcg aggtcgcgcg cgttgtcggg
     4081 ggtggtgaag tggtcgagcc ggtcgccggc ccgtgcggcg caagccgtcg cgtacgccgc
     4141 cgccttccgc cgcatcgccc gcttgtacgc cgcggagggg tcgcgcgggg agcgggccgg
     4201 acgggcggcg gcccgtccgg cccgctcccc gcacttcagc ggggcggacc ggccgacgcc
     4261 gcggggggcg taacccacga agtcgtacgc cttgttgagc ttcctccaca cggggtcgcc
     4321 gaagggagcc gcgtacatcg ggaagctcat gccgttgccg cccgggccgc cggggttgta
     4381 cagcagcgct ccctggcgtg cggggcccgt cgctccgcgc ctgctgacgg tgagccggat
     4441 cttctcgccc gcggggcgcg cgtagtcgac ggggaccgtg accttcccgc actccaccgg
     4501 cgcgggaagc tgctcggcgg cgggacactc cgtccagtcg atcccggcgg ccgcggcggc
     4561 ggacgcggcc gacgcggtgc cggccttctc ccgggcgtcc cggaggggga acggcacgac
     4621 ttccggcgcg ctcccggacg gtacgacggc ggcagccgtc agcaccaggg cgctgagtgc
     4681 gccgtggagt gcaactgagc gcacagggag cctcgttcct gctcgtccgc gagggctgac
     4741 gctgaccggg acccttgccc cgggagggag cggagagtgg gcagtcgtga gcggtgagtg
     4801 acaagtcgga tgctctgtgc gggagttggt gaagtaaagg accgcggcgc ggtgtcggcg
     4861 tgatgcgctc gatgcagcga cggcccacgc ttctgtgcgg gtggtgcggg tggtgcgggt
     4921 ggtgcgggtg gtggggtggt gggggtggtg cgggcggtat cggcagggtg cggtgccggt
     4981 cgcgtcgcgg gggtgggccg tcagcgcgtc tgccgggcgg cgcgcagcag gtacagggcg
     5041 cggcgcaccc ggccttcggg cggcggtgtc gcgccggagc gttcgagcca ccagcggcgc
     5101 accttcagcc gggtggcccg gtcggccacc gtgccctcct ccgtcagaca gtgtgcgaag
     5161 tccagggcgt cgcgccggta gccgccctcc atcgggcggc cgcgcgcgta ggcggcgaac
     5221 tcggtgcgga aggtcttctc accgaggatc tccggcagtt cgggtgcgat cttcgcgacg
     5281 acatcggctc gattgccgat cagggcccgc cgctgcacgg ccagccgttc cgcgtcgaag
     5341 ccgtcaggca cgggtccgtc cgcgaccagc gccgccagca gcgcggtctg ggcatgggcg
     5401 agccgctcac gggccgcgga ggtgccgctg ccggggtgtg tctcagccat gccgggcctc
     5461 cgctcccgcg ccgctgcccg cgaggacggc gcgtatgccg tccagttcgg ccgccagttc
     5521 ggcgacgggc gggaagttct cgtcgcgttc cagcagcact ccgggcggcg cggtccgggc
     5581 acacagctgc gcgagtacgt ccaggacggg ccgcggcacc gggtggccgt ggctgtcgtg
     5641 ccagacgccg tcccgctcga atccgcccgc gacgtgcacg tacgccaggg cgtcgagggg
     5701 gagttcgccg agcgcgaccg ccgggtcctc gccgcggttg acgtggttgg tgtgcaggtt
     5761 ggcgacgtcg atgagcaact ggacgcccgt acgctccacc agctcggcga ggaagcgtcc
     5821 ctcgctcatc tcctcgcccg gccagttgac gagcgcggcg atgttctcca cggcgagcgg
     5881 caccggcagc gcctcctgcg ccgccgccac gttctcgcag agcacgtcca gcgcgtcgcg
     5941 agtgcgcggc acgggcagca ggtggcccgc ctccatacgc ggccggcccg tggcgccccc
     6001 gccggcccgt acgaaggcga tgtgctcggt gaccagcggg gcctgaagcg cctccgcgcg
     6061 ctcggcgagc gccgcgagct tcgcccggtc ggggcggtcg gctccgccga ggccgagcga
     6121 gacgccgtgc gggacgatct tcgttccgcg ctcgctcagg cgcagcagcg gctcgggaag
     6181 atgatccggg cagacgttct cggcgacgac ctcgacccag tcgatgcccg gcagcgcctc
     6241 gatgccgtcc gcgatctcgg gccgccaccc gatgcccgta ccgagccgga ccctcgtgtc
     6301 cgtggcccgc gtgccggtgg ccctggtgtc cgtggcccgc gtgccggtgg ccctgatctc
     6361 cgttgcctcc atgtgcgttc ctcccccgtg gagccgtcag cgcgacggct ccggtcgtcc
     6421 tgtgcaccgg ccagtgcgat ccggtggtcg cgccccctgc gccgctctac gggcttctgc
     6481 cacgcagcgg ccgcccgaac cccgggcacc gggatttcag agccctgctt gagctttcac
     6541 tcctcgcgca ggtgggatca gcggtccagc gccgggtgat cggcgacgac cgtgcaggtg
     6601 cccggggcga tctcggtgtg gcccgcgtcc tgcacgacgg ggaggccgct gcgcaccagc
     6661 ctctcccatt ccgccctgtc cggcgccctg cgtacggcga gagcgaaacc ggtcgccgcc
     6721 caggccgcac ggtcctccga cggcagccgc caccaggcca gttgggctcc gtgcgcggcc
     6781 tgcgccatcg ccttgcccgc ggacatctcc agcccgggag ccatccacag caccgcagtt
     6841 cccgccacgg gccgcgcggg cgggtgcgcg tcgtccagga cggtgcccga aacctgcagc
     6901 cgtgacaggt ccttgggcca tccgtccacg gggacgggcg ggaagacgcg gacggacgcc
     6961 gtgccgcccg tgacggtgat gcccggcagc gcctgcgcgc ggcgccactc cgctccgcgt
     7021 gcccgccgta cgaccttgcg gatgtcgcgc tgctcccacc gccgcacggc ctccgcccat
     7081 tcccccgccc ccgcagtccc gggttccccc tcggccgtgc ccggctccgc gaagtcgcgg
     7141 ccgggggcgc tgcgttcgtc ggcgaggagg gtgagcacgg cgcgggcggc ggtctccagg
     7201 gcgtcggtca gggcgggcgg agcgtcccgt tcgagccgta ccaccagcgg cagcgcgtag
     7261 tcggctgcct tctgtgcgtc ctgtgcgtcg atcacccacc gaagtctgcc agcacgggct
     7321 aacgtcggca gacatgagat cggaccaact ctcatgaggc tggacggggt cggccgccgg
     7381 tacggctggc gcggagactg ggtgctgcgc gaagtggacc tctccctgcc cgaacgcagc
     7441 ctggtgcgct tcgaagggga caacggcagc ggcaagtcga cgctgctgcg gatgctcgcc
     7501 ggtgtcgaga cccccacgga agggcagatc acggggcgcc cgtcctgcgg ctacgtaccg
     7561 gagcgcttcc ccgccgcgat gccgctcacg acgcgcggct acctgaccca cctgggccgc
     7621 gtgcacggcc tgagcaggac cgtcgccgtc cgccgggccg gcgagtggct ggagcggttc
     7681 ggggccgcgg gccactccga caccccgctg tcggaactgt ccaaggggac gagtcagaag
     7741 gtcgccgtca cgcaggcgct gatggcgcgc cccgggctgc tcgtgctgga cgaggcgtgg
     7801 accgggctcg accacgacgc ccgcaccgtg ctggaccacg ctgtcgccga gcgggtggcc
     7861 gagggggcga ccgtcgtctt cgtcgaccac gaccccgggc gcctcgccgg tgcgtccgac
     7921 gcgacgtaca ggatcgaagg ggggcggttg cggcccgtcg ccgagaagga cggaccgcgc
     7981 cgccccggcc gggcggcggg cggggggaag cgcgtacgcg tcgtcgccga ggggcctccc
     8041 gggcagccgc cgccggcgct gcccgcctcg gtgatcgcgg agcagttgcc gggcggcacg
     8101 atcatcctga ccgccccggt cgcctactcc gacgtcctgc tcgggagcct gctcgagcag
     8161 aactggtaca tccggtccgt acgcgaggaa tccgcatgag tgccctgctc ggctaccaca
     8221 cggcgctgct gatgcgctcc cagcgctggc tgccgcccat gctgctctac gccgccgtca
     8281 tggggatcgg cgtgcagtgg gggcagcccg tgctggacgg actcgggtac gccgcggccg
     8341 ggctgctgcc cgtgaccgcc tgggtggtcc gcatctgcct gaacatcgag cccctggccg
     8401 cacggcagtg caccgccgcc gccgcgggac ccgcgcgggt gcatctggcc ggcgtcctcg
     8461 ccgcgctgct tctgacctgc gccctcggcg cggtgggcgc cgtctacgtc gtggcagtca
     8521 gcgacccgcg gagttcggcc gggcacgtgg cggtgccgct gctgcccgct gtggaggccg
     8581 ggctgctggc cgcgttcacg tgcgcgttct tcggcgcggc catcggcgcg ctgtgcaacc
     8641 gcccgctgct gagcaactcg ggggtcgccg ttccgtcgag cctgctggcg gtgctgctcg
     8701 tcctcgtcgt gggaggctcc ccggcgaacg ccgcggtcgc cggcctcgtg tccgcctcgc
     8761 acgagggcgc cgtgaccctg ccctggctgc cggccgtggc gtccgtggcc gtggcggcgc
     8821 tggcgacgtg gctggcctgc tcgcaggcgg gacgccgggg ttaggcgcgg cccactgcgg
     8881 ctgctctgct gttgcgcttc tggctcctcg cgcccgtccg gtggcccccg gccgcccggc
     8941 ggcgcgcatg cgttctgaca ggcggtgccc tccgacctct gtccgaatcg cccgaagttt
     9001 gccgaaagag ctttttgtga accggctctg ggtgagcaag cgaccgtcat tcgcgaggag
     9061 tctccctccg tgctgacccg tctcccgggc tcctgggtcc accgggctcc gggccggggc
     9121 ccgcgtccgc gacgcgtggc ggtcttcccg cagacagagg agaggcgatg gccaaagcgc
     9181 tgagccggca acgacgggca ccggccgttc cggacatgcc ggtggagctg tccgtgaacg
     9241 gccgccggta caaactgcac ttggacacca gggtcaccct gctcgacgcg ctacgcgacc
     9301 acttgggcct gaccgggacg aagaagggct gtgaccaggg ggcatgcggg gcgtgcaccg
     9361 tgcacgccga cggcaggcgt gtgctgtcct gtctgacgct ggccgcccag tgcgaggacc
     9421 gggagatcac cacgatcgag gggctgggcc cgtcggagga gccgcaccct ctccaggagt
     9481 cgttcgtccg ccacgacggc ttccagtgcg ggttctgcac accgggccag atcatgtcgg
     9541 ccgcggccct gctggcggaa ggccgggccg gctcggacgc cgacatccgg gagttcatga
     9601 gcggcaacct ctgccgctgc ggtgcgtacg ccaacatcgt cgccgcgatc cgcgatgtgg
     9661 cctcagcagg gggtgccgat gcgtcccttt gactacgtgc gggcggccga cgtcgacgag
     9721 gcggtgaacc tgctggccgc cgaccccgcc gcgtcctacc tcgcgggagg cacgacccag
     9781 ctggacctga tgaaggacgg agtcctcgga ccggagcggc tggtcgacat cacgcgtctg
     9841 cccctgcgcg gcatcacccg gagcgacgac gccctgcacg tcggggcgct cacgacgatg
     9901 gaggagctcg cggccgacac cacggtggag cggagcctgc ctctcgtgcg gcaggcactg
     9961 ctgctcggcg cgtccacgca gctgcgcaac atggcgacgg tcggcggcaa ccttctgcag
    10021 cgggcacggt gccgctactt tcgcgatccc gccgtccccg agtgcaacaa gcgcgatccc
    10081 ggctccggct gcgcggccgt cgagaacacc gcgaggatgc acgcgatcct gggcgtcagc
    10141 gaccggtgca tcgcggtgca cgcctccgac ctcgccgtcg ctctggtcgc actggacgcg
    10201 acggtccacc tccaggggat gccgggccgc cgcagcgtgc ccctgacgca gttctaccgg
    10261 gagtccggcg cgagcccgga cgtcgagaac gtcctcgtgc acggcgagct gatcaccggc
    10321 gtcaccgttc cccttccgcc ggcctcggcc gcctcctgct acctcaaggt ccgcgaccgg
    10381 gcctcgtacg agttcgctct cgcgtcggcg ggcgtcgtgc tggtgacgcg ggagggcacc
    10441 gtcgaacacg ccagggtggc actggggggc gtcgcgtcga agccatggcg gtgcctggag
    10501 gccgagcagg tcctcaccgg ttcaccggcg acggaggaga cgttccggga agctgcggcc
    10561 gcctcggtgc agggggcgtg gaccgttccc ggcaccgaat tcaaggtcga actcgctcag
    10621 cgcaccctcg tccgtgcgct gcggaccgtc tcaggagtca cgccgtgagc ctcgtggaac
    10681 ccgcacccct cgtcggcgcc ggaatcgacc gcgtcgacgg tgccctcaag gcggccggtg
    10741 cggccgccta tccgagcgat gtgaacgtcc ccggccaggt gcatgccgcg ctcgtccaga
    10801 gcacagtcgc ctcgggacgc atccggtcgc tcgacaccct ggccgccgag gccgcgcccg
    10861 gcgtgctgag agtcatcacc caccgcggca tgccccggct tcccgacggg ccgatgaccg
    10921 ctctgggggc gtcaccgccg gcccctctcc aggacgaccg ggtcctgcac cacggccagc
    10981 atgtcgccat ggtggtggcg gagacccccg aggaggccgt cgccgcggca cggctggtgg
    11041 aggtcgagta cgagccgggc gacgccgtca cccggctcga cgacccgcgt gcccggctgg
    11101 tggagaaccc ctggggcctg gacagcgacc ggggttcggt cgcggaggcg ctcgacacgg
    11161 cggacgtgaa ggtctcggcc acctacacca cccccgacaa caccaacaac ccgctggggc
    11221 tcttcgcgac agtcgccgtg tgggagggcg acaagctcac ggtccacgac acc
//
