LOCUS       NZ_FMHJ01000008        10213 bp    DNA     linear   CON 28-JUL-2024
DEFINITION  Streptomyces sp. WMMB 714, whole genome shotgun sequence.
ACCESSION   NZ_FMHJ01000008
VERSION     NZ_FMHJ01000008.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces sp. WMMB 714
  ORGANISM  Streptomyces sp. WMMB 714
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Varghese,Neha. and Submissions,Spin.
  TITLE     Direct Submission
  JOURNAL   Submitted (16-JUN-2016) DOE - JOINT GENOME INSTITUTE, 2800 Mitchell
            Drive, Walnut Creek, CA 94598, USA
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_900090125.1-RS_2024_07_28
            Annotation Date                   :: 07/28/2024 02:17:28
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,656
            CDSs (total)                      :: 5,578
            Genes (coding)                    :: 5,496
            CDSs (with protein)               :: 5,496
            Genes (RNA)                       :: 78
            rRNAs                             :: 6, 5, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 6 (5S)
            partial rRNAs                     :: 5, 4 (16S, 23S)
            tRNAs                             :: 60
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 82
            CDSs (without protein)            :: 82
            Pseudo Genes (ambiguous residues) :: 0 of 82
            Pseudo Genes (frameshifted)       :: 15 of 82
            Pseudo Genes (incomplete)         :: 72 of 82
            Pseudo Genes (internal stop)      :: 4 of 82
            Pseudo Genes (multiple problems)  :: 8 of 82
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 06:07:12
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 314000
            Orig. end                         :: 324213
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            FMHJ01000008.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..10213
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="2"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..10213
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10213
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:5213](+)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..5213
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     misc_feature    523..537
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 17.3"
                     /tool="antismash"
     gene            790..1209
                     /locus_tag="H181DRAFT_RS17240"
                     /old_locus_tag="H181DRAFT_03477"
     CDS             790..1209
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009077214.1"
                     /locus_tag="H181DRAFT_RS17240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="H181DRAFT_03477"
                     /product="CBS domain-containing protein"
                     /protein_id="WP_045865353.1"
                     /transl_table=11
                     /translation="MTTARDVMSPGAECVKTDQTAADAARIMTRTGLGALPICGKDDKL
                     KGVVTDRDIVVKVLGQGRDPGAFPAGDLNQREAVTIGADDTTDEVLATMSRHKVRRLPV
                     IDGHRLVGMVAVADVARTLPNATTGELVEALSADY"
     misc_feature    complement(1293..1308)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 18.95"
                     /tool="antismash"
     gene            1405..1638
                     /locus_tag="H181DRAFT_RS17245"
                     /old_locus_tag="H181DRAFT_03478"
     CDS             1405..1638
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009187919.1"
                     /locus_tag="H181DRAFT_RS17245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="H181DRAFT_03478"
                     /product="hypothetical protein"
                     /protein_id="WP_045865354.1"
                     /transl_table=11
                     /translation="MAVCEVCGNDYAETFEVRAAGAVHVFDSFECAAQKMAPICENCGC
                     RILGHGLQAEGRYYCCASCARMQGRMELADSV"
     gene            complement(1704..3023)
                     /locus_tag="H181DRAFT_RS17250"
                     /old_locus_tag="H181DRAFT_03479"
     CDS             complement(1704..3023)
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF019310.4"
                     /locus_tag="H181DRAFT_RS17250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="H181DRAFT_03479"
                     /product="MFS transporter"
                     /protein_id="WP_045865355.1"
                     /transl_table=11
                     /translation="MPQKTTTPYDPGVRGAVVEVPGAPVTKGWTARYALASTGMWLAFL
                     TPAQVQIARQAEVFSPDGKEALLGLATGVGAAVTAVAVPAFGAVSDRTRSRFGRRRPWV
                     ALGSLLAAVGILLLATATGAVTMVCGWAVAQLGLSAVQAGLVAAIPDRVPKPQLGTVAG
                     WAGMTQMLGALLGTVLVNQLVTGLVAGYAACAVVAVVSVVPFLAGHREQDTRGAEAAPA
                     RPATAAPAPPAGGPVSGPRKSGRPLLSRPASVPRDLLWTWVSRFLVVLGFALITQYLLY
                     YLTDALRVDEPQEAMLTVTAATVLCAMAAALIAGRWSDRAGRRRVFVAAGGAAMGLGAL
                     GLALLPSWPVTVGAAIAVGTGFGTFLAVDLAVIASVLPSAADTGRDLGIFAIATATPQV
                     LAPVLAVPVLAVAGYGGLYVLTAVVSAAGGAAVLLVRSVR"
     gene            complement(3334..3810)
                     /locus_tag="H181DRAFT_RS17255"
                     /old_locus_tag="H181DRAFT_03480"
     CDS             complement(3334..3810)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018546554.1"
                     /locus_tag="H181DRAFT_RS17255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="H181DRAFT_03480"
                     /product="phospholipase"
                     /protein_id="WP_045865356.1"
                     /transl_table=11
                     /translation="MRRRLTSGLVVSSAALLAVMGSATTAVADPADKPQVLSSWTQTSA
                     SSQNAFLAARANQGNWAAYNFDWSTDVCSSSPDNPFGFPFENGCIRHDFGYRNYKAQGT
                     FEANKARVDSAFYEDLKRVCAGYSGATKASCDALAWTYYQAVKVLGFEKASPVG"
     gene            5001..5213
                     /locus_tag="H181DRAFT_RS17260"
                     /old_locus_tag="H181DRAFT_03481"
     CDS             5001..5213
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: strepbact"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020128984.1"
                     /locus_tag="H181DRAFT_RS17260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="H181DRAFT_03481"
                     /product="hypothetical protein"
                     /protein_id="WP_045865357.1"
                     /sec_met_domain="strepbact (E-value: 1.1e-26, bitscore:
                     87.4, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDFTPQVETREISDNDLDNVSGGVLGAVVGTAVSTADSVAPVSET
                     VATVNGTVSGATGIDTSQVTGLAGL"
     misc_feature    complement(5488..5508)
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 20.22"
                     /tool="antismash"
     gene            5572..6378
                     /locus_tag="H181DRAFT_RS17265"
                     /old_locus_tag="H181DRAFT_03482"
     CDS             5572..6378
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014058236.1"
                     /locus_tag="H181DRAFT_RS17265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="H181DRAFT_03482"
                     /product="HlyD family efflux transporter periplasmic
                     adaptor subunit"
                     /protein_id="WP_045865358.1"
                     /transl_table=11
                     /translation="MQFRQKAFSKLQSPEELDLPVRFARPQGWLVLLVTVLVMAGAGYW
                     AVTGKVSGKLHAPGILTHSQGSYVLQSPVSGQVTQVLAEEGTMLRAGAPVLKVRTERGF
                     RAVRTVAAGRMTTLTAKIGTVVTTGKDVATVERIESTDEPLVAMVYVPGHNGASVRVNS
                     RVDLTVQSAPTEKYGVLRGRVKAVGRAPQTRQQLTGFLGNAQLAEEFSKEGQPVAVMVQ
                     LERASGTESGYRWSSDEGPPYALDSMTMTDAAVHQPAQRPVDWLLP"
     misc_feature    complement(5586..5597)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 16.66"
                     /tool="antismash"
     gene            6549..8675
                     /locus_tag="H181DRAFT_RS17270"
                     /old_locus_tag="H181DRAFT_03483"
     CDS             6549..8675
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015576114.1"
                     /locus_tag="H181DRAFT_RS17270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="H181DRAFT_03483"
                     /product="NHLP family bacteriocin export ABC transporter
                     peptidase/permease/ATPase subunit"
                     /protein_id="WP_302622646.1"
                     /sec_met_domain="Peptidase_C39 (E-value: 2.3e-38, bitscore:
                     125.3, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLQMEAVECGAAALAMVLGHYGRHVPLEELRIACGVSRDGSRASN
                     LLKAARSYGLEAKGMQMEPAALAAVAAPAVLFWEFNHYVVYDGMGRRFGRRGVFINDPD
                     KGRRFVPLEEFDTSFTGVVLTFEPGDDFRPGGRRPGFLSAMPARLRGTTGTMLAALLAS
                     LLLVAVGAAVPALSRTYIDMFLIGNETSLLSVLFASMGAMVLLTAVLTGLQQANLLRGR
                     IISSTLSSARFFRHLLRLPVTFFAQRSPADLVQRLQSNDTVAETLARDLAAAGVDAVVV
                     VLYAVLLWTYDPQLTLIGVLIALLNLVAMRVVIRLRATGTQKLRADTARLTNTSYTGLQ
                     LIETMKATGGENGYFRRWAGQHATTLEEQQKLGVPSAALAVVAPTLATLNSAMILLIGG
                     MRAVEGHISIGLLVAFQALVTRFTAPITRLNGVAGRIQDFAADVARLKDVENFPVDSLY
                     SRRAPAASTRRLKGHVSLENITFGYSPLDKPLLTEFSLSVSPGRQVALVGGSGSGKSTI
                     SRLISGLYSPWEGVIRIDGQRLEDIPRSSLAASVSFVDQDVFLFEGTVRDNVALWDPSI
                     PDEAVTAALQDAAVYEDFARRPGGIRCRVEQDGRNLSGGQRQRLEIARALVRRPSILVL
                     DEVTSALDARTEQVIIDNLRRRGCACVVIAHRLSTVRDSDEIVVLDHGTVVERGRHEEL
                     VAAGGQYAELVKEH"
     misc_feature    9419..9434
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: weak,
                     score: 16.86"
                     /tool="antismash"
     misc_feature    complement(9563..9577)
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 18.86"
                     /tool="antismash"
ORIGIN
        1 gccatggcga cggaggagaa cggcggcgcg cagctcgcgc tgatgaaccc cggcggcatc
       61 cgctccgacc tcacccacgc cgcctccggc aaggagggcg acggcgtcgt gacgtacggc
      121 gagggcttca ccgtgcagcc cttcaccaac atgatgacga ccatcgacct caccggcgag
      181 cagctgatca ccgctctcca gcagcaggtc agcggggaca acgaagccga gcccaagatc
      241 ctccagccct ccgagggctt cacctacacc ctcgacatga cgaagtccgg caaggaccgc
      301 atcgtcacgg actcggtgaa gctggacggc aaggccatcg aggcgggcga gacgtaccac
      361 gtcgcgatga acgagttcct cgcgggcggc ggcgacggct tcccgatctt caaggaggcc
      421 aaggacaagc tcgtcggcgc gtccgacctg gaggccctgg aggcctactt cgcggagcac
      481 tcctcggagt ccggcccgct ggccccgccg aaggcggacc gcatcaagat cgtcgagtga
      541 cgatcggccc ctgaccggaa gggcgcgagc gcgtccctcc ggcccggccg cgcacgacgg
      601 tgccctgccc cgtggaagac cacggggcag ggcaccgccg cgtgtgcgga gcggtgcggc
      661 tcccggccgt gcgcggggtc aggtttgaag gcgaccgccg cgtgctaccc ggctccgggc
      721 cgtccgtgct cctccaggag cgggggcggg cacagcaatg ccgcgaacgt atgccgtcag
      781 gagcgatcca tgactaccgc acgcgatgtg atgagccccg gcgccgagtg tgtgaagacg
      841 gatcagaccg ccgccgacgc cgcccgaata atgacgagga ccggcctggg cgccctgccg
      901 atctgcggca aggacgacaa gctcaagggc gtggtcacgg accgggacat cgtcgtgaag
      961 gtgctcggcc agggccgcga tcccggggcc ttccccgccg gcgacctcaa ccagagggag
     1021 gccgtcacga tcggcgccga cgacaccacc gacgaggtgc tcgccaccat gagccgccac
     1081 aaggtgcgcc gtctgccggt gatcgacgga caccggctcg tcggcatggt ggcggtcgcg
     1141 gacgtggccc gcacgctgcc gaacgccacg accggcgaac tcgtcgaggc cctgtcggcg
     1201 gactactgac ggcgcggccc gggcaccgtc ccgccccggg cggcggtcac caggacgaga
     1261 gaggacgcga acaggtccgg caccggcgca ccgcgaaaga cccgtgaaga gcagtcagtc
     1321 agcctcttcc acctcacgaa gtcaccacgt caccacgtcc cttcctttcc ttcacgcttt
     1381 ccttcacgcc accgaggagc cgagatggcc gtatgtgaag tctgcggaaa cgactacgcc
     1441 gagaccttcg aagtccgcgc ggccggtgcc gtgcacgtct tcgacagctt cgaatgcgcc
     1501 gcacagaaga tggcgcccat ctgcgagaac tgcgggtgcc gcatcctggg gcacggactg
     1561 caggccgagg ggcgctacta ctgctgtgcc agctgcgccc gcatgcaggg ccggatggag
     1621 ctggccgaca gcgtctgagg ctccccgtgg gccgccgcga acggacggcg gcccacggag
     1681 gtgtctctcc ggtgcggcgg cgtctacctg acggagcgca ccagcagtac ggcggcgcct
     1741 cccgcggcac tgacgacggc cgtcagcacg tacaggccgc cgtagccggc gacggcgagc
     1801 acgggaaccg ccaggacggg cgccaggacc tgcggcgtcg ccgtggcgat ggcgaagatt
     1861 cccaggtcgc ggcccgtgtc ggccgccgac ggcagtacgg aggcgatgac ggccaggtcg
     1921 acggcgagga acgtgccgaa gcccgtgccg acggcgatcg ccgcaccgac ggtgacgggc
     1981 cagctcggca gcagcgccag accgagggcg cccaggccca tcgcggcgcc gcccgcggcg
     2041 acgaacacgc gcctgcggcc ggccctgtcg gaccagcggc ccgcgatcag cgccgccgcc
     2101 atggcgcaca gcaccgtcgc tgcggtgacc gtgagcatcg cctcctgggg ctcgtccacc
     2161 cgcaacgcgt ccgtcaggta gtacaggagg tactgcgtga tcagcgcgaa gcccaggacg
     2221 acgaggaacc tgctcaccca cgtccacagc aggtcgcgcg gcacggaggc gggccgggag
     2281 agcagcggac gtccggactt ccggggtccg ctcaccgggc cgccggccgg cggggcgggg
     2341 gcggccgtgg cggggcgggc cggagcggcc tccgctccgc gggtgtcctg ctcgcggtgc
     2401 cccgcgagga acggcacgac ggagacgacg gcgaccacgg cacaggccgc gtatccggcg
     2461 acgaggccgg tgacgagctg gttgaccagc accgtcccca gcagggcccc cagcatctgc
     2521 gtcatcccgg cccaccccgc gaccgtgccc agctgcggct tcggcacccg gtccgggatg
     2581 gcggcgacca gccccgcctg cacggcggac agcccgagtt gggccaccgc ccatccgcag
     2641 accatcgtca ccgccccggt cgcggtggcc agcagcagga tccccaccgc cgccagcagg
     2701 ctccccagcg ccacccacgg cctgcggcgc ccgaagcggg agcgtgtcct gtcgctgacg
     2761 gctccgaaag cggggaccgc caccgccgtc accgccgcgc ccaccccggt ggccagcccc
     2821 agcagggcct ccttgccgtc aggcgagaac acctcggcct gacgggcgat ctgcacctgc
     2881 gccggagtga ggaaggcgag ccacatgccg gtgctggcga gcgcgtagcg cgcggtccag
     2941 cccttggtga ccggtgcgcc gggcacctcg acgacggctc cccggacacc ggggtcgtac
     3001 ggggtcgtcg tcttctgggg catgtcgctc tccgcggtgc gcgtccggca ggggcaaggg
     3061 ctggggcggg gactggggct gtggcagcgt gatgccctgc ccttgcgcgc tgcttgcgcg
     3121 gcggtgctcc gtgctctgac cgccgggcga ggacgacggt cgtggcgagg accggttgaa
     3181 cgaggaccgg ttgaacgagg gcgccggtcg tgcgaggacc ggtcgtgcga agccgtagac
     3241 gcatggaagc gcggggcgcc cgtcgagggc gccccgcgct tcctgcacgc gctgcgggcg
     3301 tggtcgtgcg ccgggaccgg gccgggcgcg ggatcagccg accgggctgg ccttctcgaa
     3361 gcccagcacc ttcaccgcct ggtagtaggt ccacgcgagt gcgtcgcagg aggccttcgt
     3421 ggcgccgctg tagccggcgc agacgcgctt gaggtcctcg tagaaggcgc tgtcgacacg
     3481 ggccttgttg gcctcgaagg tgccctgcgc cttgtagttg cggtagccga agtcgtgccg
     3541 gatgcagccg ttctcgaagg ggaagccgaa cgggttgtcc ggtgacgagg agcagacgtc
     3601 cgtcgaccag tcgaagttgt aggcggccca gttgccctgg ttcgcccggg cggcgaggaa
     3661 tgcgttctgg ctcgaggcgc tggtctgcgt ccagctggag agaacctgag gcttgtccgc
     3721 ggggtcggcg acggcggtcg tcgcggagcc catgacggcg aggagtgccg cggatgaaac
     3781 gaccagaccc gaagtgagtc ttcgacgcat ttcatacctc cgtgggggga cgccggtccg
     3841 gcggtcggac cgggcaatgc atgagcatga cagaacaatc gctttccaag taggcgcgtg
     3901 cgccgacgat ttcgagccga aagcggaccg ccaccggggg ccgcgcggcc cccggccccc
     3961 ctggcacggc ccgaggcccc gggacggatc ccggggcctc ggttgccaac gtgggggaag
     4021 aagcccacga ccagcctggc acttcaataa cgaaacggat gatgcatcgt cacggtttct
     4081 cgatatccgc gacgtttgac cgtaaaaccg atgatccgcg cacacctccg tccacacctc
     4141 catctccacc ccgggcacaa gcagggcacg ccctcggcac gcgcaccgga tctccgcgcg
     4201 ttcccaccag ccagccaccc ccatcgcccc cgcccacgca cacaccggcg cccgacgagc
     4261 cgtcacctct cctcctcacc ccgcgggttc ggcccggcat ggatcccgcc cgctcgccga
     4321 ggccggagca agcgcgcctc ccggtgcggg agttgacgga acgagggcgc cgtgtaaagc
     4381 ggcgtgcaaa tgcgcgcatg aattcatctg cctcgtctca ccatttgaac aagccatttc
     4441 gcccttagcg gcccttaggc gcccttaagg aagcgcggac ttcggtgcgg actctcccgg
     4501 tcacctcctg tcaccgcacc cgaactgccg cttccacgcg gtggatcagc aggtcagagc
     4561 gggttgacgg cgggaagtgc cgtacagcgg agccgatttc agcgaacctg cacaactggt
     4621 tcgtacggga ggcacatggc cccgtgagcc cgtccgcgca cacccggaag gcggtcgact
     4681 tggtgcggga atgtccaatt ggcagcgcac gcacggagtt ccggccccgg cacgcgagga
     4741 gcggcaagtg aagagttcgc cacgaattcg tggacggtac tgcacttgga agaaacaacg
     4801 tgcccggatc tgcgccgaac cggcgcacga acgagtggcc cggcagcgct ggcgcgtgct
     4861 ttgatcggcc cagacgcgga agttgaacga atggttcccg ttgtcgggca tcagacgacc
     4921 gctcgtacgg ccggacggct ttccccgagc cggccgatgc tattgagaga acatccagag
     4981 caagcgaagg gaagctcctc atggacttca cgccccaggt tgagacccgc gagatttccg
     5041 acaacgacct ggacaacgtt tccggtggcg ttctcggcgc ggtcgtcggc accgccgtca
     5101 gcaccgccga ctccgtcgcc ccggtttcgg agaccgtcgc caccgtcaac ggcaccgtct
     5161 ccggcgccac cggcatcgac acctcccagg tcacgggtct cgccggcctc tgaggcgatc
     5221 cctgccaccg agcggcggag caggccgtgc tgatcggcgc ggaaccctgc acacccggcg
     5281 catcggaatc ccagtggggt gaccgtgagc cccggaacca ttccgttccg gggctcacgg
     5341 atgcgtcccg gaccggccgt gccccggcaa tgcccgtgta ttgccgtgcc tttggcagac
     5401 gctgtcaatt cttctgtcag ccactgccgc gagtgggtat cacctctccc gccactcgtc
     5461 tctccggcgc ccgtccggcc gccctgtcat tcgtcccggc gtcgatatgg agacgccacc
     5521 gaaggaagcg tcgtgcccga aagcaacgaa cgcagttgag ggaatagccc cgtgcagttc
     5581 cggcagaagg cgttttccaa gctgcagtcc cccgaggaac tcgacctgcc cgtgcgcttc
     5641 gcgcggccgc aggggtggct cgtgctgctc gtgaccgtgc tcgtcatggc cggcgcgggc
     5701 tactgggccg tcacgggcaa ggtgtcgggc aagctgcacg cgcccggcat cctcacccac
     5761 tcccagggca gttacgtcct ccagagcccc gtctccggcc aggtcacgca ggtcctcgcc
     5821 gaggagggca cgatgctgcg cgcaggcgct cccgtgctga aggtccgtac ggagcgcggt
     5881 ttccgcgccg tgcgcacggt cgcggccggg aggatgacga cactgacggc gaagatcggc
     5941 accgtcgtca ccaccggcaa ggacgtcgcc acggtcgagc ggatcgagtc caccgacgag
     6001 cccctcgtgg cgatggtcta cgtccccggg cacaacggcg cgagcgtacg cgtcaattcg
     6061 cgggtcgacc tgaccgtgca gtccgcgccc accgagaagt acggcgtgct gcgcggcagg
     6121 gtgaaggccg tcggcagggc cccgcagacg cggcagcagc tcaccgggtt cctcgggaac
     6181 gcgcagctcg ccgaggagtt ctccaaggag ggtcagccgg tggcggtgat ggtgcagctg
     6241 gagcgcgcga gcggcaccga gtcgggttac aggtggtcct ccgacgaggg cccgccctac
     6301 gcactggact ccatgaccat gaccgacgcc gccgtgcacc agccggccca gcgtcccgtc
     6361 gactggctcc tcccgtgacc gccccgcgga ggaccgcgga ggacgggcag ccggggctcc
     6421 cgccaccggg ccgcggcagg caccgccccg aaggaaaggg cggcggcagg caccgtacgg
     6481 gcaaaggcgc gcccgcgggt cccgcgcctg tcccgaaacc cgagttcaag gccgtccgca
     6541 gccccaccgt gctgcagatg gaggcggtgg agtgcggcgc cgcggcgctg gcgatggtgc
     6601 tcgggcacta cggacgccac gtgcccctgg aggagctgcg catcgcctgc ggcgtctccc
     6661 gcgacgggtc acgggccagc aacctgctga aggcggcccg cagttacggc ctggaggcca
     6721 agggcatgca gatggagccc gcggcgctcg cggcggtcgc ggcaccggcc gtgctcttct
     6781 gggagttcaa ccactacgtc gtctacgacg gcatggggcg gcgcttcggc cggcgaggcg
     6841 tgttcatcaa cgaccccgac aaggggcgcc ggttcgtgcc gctggaggag ttcgacacca
     6901 gcttcacggg cgtcgtgctg accttcgaac cgggtgacga cttccggccc ggcggcaggc
     6961 ggcccggctt cctgagcgcc atgccggccc ggttgcgcgg cacgacgggc acgatgctgg
     7021 ccgcgctgct cgcgtccctg ctgctcgtcg ccgtcggcgc ggccgtgccc gcgctgagcc
     7081 gcacgtacat cgacatgttc ctgatcggga acgagacgtc gctgctgagc gtgctgttcg
     7141 cctccatggg cgccatggtg ctgctgacgg cggtgctgac gggcctgcag caggcgaacc
     7201 tgctgcgcgg gcgcatcatc tcctccacac tcagcagcgc ccgcttcttc cgccacctgc
     7261 tgagactccc ggtcacgttc ttcgcgcagc gcagccccgc ggacctcgtg cagcggctgc
     7321 agtccaacga caccgtcgcg gagaccctgg cgcgggacct ggccgccgcc ggcgtggacg
     7381 ccgtcgtcgt ggtgctctac gcggtgctgc tgtggacgta cgacccgcaa ctgaccctga
     7441 tcggcgtgct catcgccctg ctgaacctcg tcgcgatgcg cgtggtgata cgcctgcggg
     7501 ccaccggcac gcagaagctg cgggccgaca ccgcccgcct gaccaacacc tcctacaccg
     7561 gcctccagct gatcgagacc atgaaggcca cgggcggcga gaacggctac ttccgccgct
     7621 gggccgggca gcacgccacc acgctggagg agcagcagaa gctgggcgtg ccgagcgcgg
     7681 ccctcgccgt ggtcgccccc acgctggcca cgctgaacag cgcgatgatc ctgctgatcg
     7741 gcggcatgcg ggcggtcgag ggccacatct cgatcggcct gctcgtggcg ttccaggcac
     7801 tggtgacgcg cttcaccgca cccatcacgc gcctcaacgg cgtcgcgggc cgcatccagg
     7861 acttcgccgc cgacgtggcg aggctgaagg acgtggagaa cttcccggtc gactcgctct
     7921 attcgcgccg cgctccggca gcgagcaccc gccgcctcaa gggccatgtg tcgctggaga
     7981 acatcacgtt cggctacagc cccctcgaca agccgctgct gacggagttc tcactctccg
     8041 tcagcccggg ccgccaggtc gctctcgtcg gcggttcggg gagcggcaag tccaccatct
     8101 cgcggctcat ctcgggcctc tacagcccgt gggaaggcgt catacgcatc gacgggcagc
     8161 gtctcgagga cataccccgc agctcgctgg ccgcctccgt ctccttcgtc gaccaggacg
     8221 tcttcctctt cgagggcacc gtccgcgaca acgtcgcgct gtgggacccg tcgatccccg
     8281 acgaggccgt caccgccgcc cttcaggacg ccgccgtgta cgaggacttc gcccggcggc
     8341 ccggcggcat ccgctgccgc gtcgagcagg acgggcgcaa cctctccggg ggtcagcgcc
     8401 agcgtctgga gatcgcgcgg gcgctggtgc gcaggcccag catcctcgtc ctcgacgagg
     8461 tgaccagcgc gctcgacgcc cggaccgagc aggtcatcat cgacaacctc cggcgccgcg
     8521 gctgcgcctg cgtcgtcatc gcgcaccggc tgagcaccgt ccgcgacagc gacgagatcg
     8581 tggtactcga ccacggaaca gtcgtcgaac gcggccgcca cgaggagctg gtcgcggccg
     8641 gcggccagta tgccgagctg gtcaaggagc actgaggtgg catccgcgca cggccccgga
     8701 gagcagagca ccgccggcta cggcccgggg gcgtacgggg aggcgccgta cgacggcgcc
     8761 gggacgtacg agcacgggaa cggcgccgca acgtacgccg acggctcacg ggagacggcg
     8821 gcccgcgccg aagtgccgca cgcgggcggc gaggccacgc cgtccgccgc cccgccgtcc
     8881 gcggcgtacg gctccgccgc cgcagccacc gcggagcccg cggccacggc acccggctcc
     8941 gccgcgtccg atcccgtcgt cgacgcgttc ggcacgctcg gcgaaccggc gggcagcgac
     9001 ggccggcgca gcatgcccct cgaaggcccg cacgtgctct ggctggtgac ggccggggcg
     9061 atggacctgt tcgccgtcga cgccgccgcg caggggcact ggcacttcct cggccggctg
     9121 gaggcgggca ccctgctgct cgggcccgtc gaaggcccgg agcacaccct cgtcggcaga
     9181 ccgctgcgcg aatgcggcct gcgccgcatc gagttgcggg agctgttcac gcccgaacac
     9241 gacgcgtacg gcgcgtacgg cgcgacgtcc gcgtacgggg ccccctacgg cgccgccgga
     9301 tacggcgggg gcgccgcgtc cccgtccgcg ctcgacacgg ccttcgcgct gggcgtcggg
     9361 cgcggcctcc gcgtactgca cgaggcgccc ctggacggcg aggtgacgcc tgaggccggg
     9421 caccccggcg tcaccggggg cacggacgac gacgagatcc agtggatgcg gctggagccg
     9481 gggagcgtgc agtacggcgc cgtcttcagc caggaggccg cgtcgcagct cctggtcgac
     9541 ggccgggcct ggcagcgcat ggtggaccag cagttccggc tgctctccgc cctggaccgc
     9601 tggatcgagc ggctggagcg cgcccacgag gaccgtacgg ccgccggcat cgaggccggc
     9661 gaggcggtgc gtgcccaggc cgaccaggcg ctgctggcct ccatcgacac cacggggaag
     9721 ggcgcggccg aagccgcccg cgccacggac gacgacactc tcaccgtcgc ccggctcgcc
     9781 gccggtgccg ccgggatcga gctctccgcc ccggaggaga gcagttcgct gagcgaccgc
     9841 acgaaccccg tggagcgcat cgcgctcgcc tcgcgggtgc gtacccgggt cgtcaaactg
     9901 gacggccgct ggtggcggcg gaacgcgggc ccgctggtgg ggcaccgctc gggcagcggc
     9961 gctccggtgg ccctgctgtg gcgccgcggc cggtacgagg cggtggacgc ctccggcgag
    10021 cgcgtcagga ccggccggtc cacggcgggc cggttcgagc cgcgtgccgt gatgttctac
    10081 cggccgctgc ccgaagaacc cctcaacgcc tggcagttgc tccgcttcac tctccgcggc
    10141 acccgtatgg acgtgcggaa cctggcgctg ggcggcctgg tcgccgtcgg cctgggcgcg
    10201 ctggtgccca tcg
//
