LOCUS       NZ_FMHJ01000004        20705 bp    DNA     linear   CON 28-JUL-2024
DEFINITION  Streptomyces sp. WMMB 714, whole genome shotgun sequence.
ACCESSION   NZ_FMHJ01000004
VERSION     NZ_FMHJ01000004.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces sp. WMMB 714
  ORGANISM  Streptomyces sp. WMMB 714
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Varghese,Neha. and Submissions,Spin.
  TITLE     Direct Submission
  JOURNAL   Submitted (16-JUN-2016) DOE - JOINT GENOME INSTITUTE, 2800 Mitchell
            Drive, Walnut Creek, CA 94598, USA
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_900090125.1-RS_2024_07_28
            Annotation Date                   :: 07/28/2024 02:17:28
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,656
            CDSs (total)                      :: 5,578
            Genes (coding)                    :: 5,496
            CDSs (with protein)               :: 5,496
            Genes (RNA)                       :: 78
            rRNAs                             :: 6, 5, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 6 (5S)
            partial rRNAs                     :: 5, 4 (16S, 23S)
            tRNAs                             :: 60
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 82
            CDSs (without protein)            :: 82
            Pseudo Genes (ambiguous residues) :: 0 of 82
            Pseudo Genes (frameshifted)       :: 15 of 82
            Pseudo Genes (incomplete)         :: 72 of 82
            Pseudo Genes (internal stop)      :: 4 of 82
            Pseudo Genes (multiple problems)  :: 8 of 82
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 06:07:12
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 413624
            Orig. end                         :: 434329
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            FMHJ01000004.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..20705
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="linaridin"
                     /region_number="3"
                     /rules="(cypemycin or cypI)"
                     /tool="antismash"
     cand_cluster    1..20705
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(cypemycin or cypI)"
                     /kind="single"
                     /product="linaridin"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..20705
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:10705](-)"
                     /cutoff="20000"
                     /detection_rule="(cypemycin or cypI)"
                     /neighbourhood="10000"
                     /product="linaridin"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..10705)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(cypemycin or cypI)"
                     /neighbourhood="10000"
                     /product="linaridin"
                     /protocluster_number="1"
     misc_feature    1002..1016
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 18.76"
                     /tool="antismash"
     gene            1275..2768
                     /locus_tag="H181DRAFT_RS09660"
                     /old_locus_tag="H181DRAFT_01947"
     CDS             1275..2768
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018513570.1"
                     /locus_tag="H181DRAFT_RS09660"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="H181DRAFT_01947"
                     /product="N,N-dimethylformamidase beta subunit family
                     domain-containing protein"
                     /protein_id="WP_045863850.1"
                     /transl_table=11
                     /translation="MGTEDIRHWESGALAHAATDPFGQGPLPWLRFGEQYFDNGRMVPW
                     YVDQTGLEGLLPGESLSQPGVGRPRTADDVHCQIKGFAGSDGGTAPGDSLDFRITVDPP
                     QAFAVDVYRVGHYGGIGATKITTSPRLSGIRQPPPLTADRTVSCHNWWLSWRLQVPSHW
                     STGAYVAVLTTADGRHRSHIPFTVRDRDPADLLVVLPDLTWQAYNLFPENGRDGASLYH
                     AWDDHGRLLGEEDAAVTVSFDRPYAGAGLPLHIGHAYDFIRWAERVGYDLAYADARDVH
                     AGRVDLAAHRGVIFPGHDEYWSVPMRRSVERARDGGTSLVFLSANTMYWQVDLDPLPGG
                     SPDRLLTCRKRRGPGRSAQWRSQGEPEQHILGVQYAGQVPEPYPLIVRNSEHWLWEGTE
                     AGDGDGIPGLVAGEADRYFPRTSLPEYTERVLLAHSPYQDTGGARRHQETSLYRAPSGA
                     LVFCSGTFAWTPALDRPGHVDSRVQRATANLLDRVCKSD"
     gene            3002..3940
                     /locus_tag="H181DRAFT_RS09665"
                     /old_locus_tag="H181DRAFT_01948"
     CDS             3002..3940
                     /EC_number="6.3.2.6"
                     /GO_function="GO:0004639 -
                     phosphoribosylaminoimidazolesuccinocarboxamide synthase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006164 - purine nucleotide biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003974901.1"
                     /locus_tag="H181DRAFT_RS09665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="H181DRAFT_01948"
                     /product="phosphoribosylaminoimidazolesuccinocarboxamide
                     synthase"
                     /protein_id="WP_045863851.1"
                     /transl_table=11
                     /translation="MSGFVEKPEPVQVPGLLHLHTGKVRDLYRNEAGDLVMVASDRVSA
                     YDWVLPTEIPDKGRILTQLSLWWFEQLADLVPNHVISTEVPAGAPADWEGRTTVCRSLR
                     MIPVECVARGYLTGSGLAEYEQARTVCGLALPEGLTDGSELPGPIFTPATKAAVGDHDE
                     NVSYEEVAREVGAETAAQLRQLTLAVYQRARDVALDRGIILADTKLEFGHGTGADDGIG
                     VPAENHVGLFLGDEVLTPDSSRFWPADQWQPGRPQPSFDKQFVRDWLSGADSGWDRNGQ
                     LPPPPLPEKIVEQTRAKYVEAYSRLTGLDWA"
     tRNA            complement(4159..4231)
                     /anticodon=(pos:complement(417820..417822),aa:Gly,seq:gcc)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="H181DRAFT_RS09670"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /old_locus_tag="H181DRAFT_01949"
                     /product="tRNA-Gly"
     gene            complement(4159..4231)
                     /locus_tag="H181DRAFT_RS09670"
                     /old_locus_tag="H181DRAFT_01949"
     misc_feature    4285..4305
                     /note="TFBS match to MntR, Manganese transport regulator,
                     confidence: weak, score: 20.91"
                     /tool="antismash"
     misc_feature    4421..4436
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 19.91"
                     /tool="antismash"
     gene            4511..5545
                     /locus_tag="H181DRAFT_RS09675"
                     /old_locus_tag="H181DRAFT_01950"
     CDS             4511..5545
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018492821.1"
                     /locus_tag="H181DRAFT_RS09675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="H181DRAFT_01950"
                     /product="response regulator transcription factor"
                     /protein_id="WP_107068726.1"
                     /transl_table=11
                     /translation="MSTNEMSYLGLTEEQEQIYRLCLREPGIGIDGLIEQLRLTPHAAR
                     EELGRLRELGLLRGGGTPEQEAGSGTAEEDGLAAADPDVAVARLLDLRLHELHEKLQQV
                     TELQPLVASLRPESAAQQPPTVVGIEQITDPPKIRDRVDDLAFFAREEVSLVEPATALR
                     PEDIEQDRPRVLRCLRRGLSVRTVLVRKALDHAPTVSYLRELESHGARVRLVSHTTAKI
                     QMYDRRTAVVPVHPEDSSRGALFAQESGLVSNILAMFESIWAESDDLGALLGERRSEGE
                     NGPSELERMVLRAMCSGGKDEAGARDLGVSVRTYRRYIADLMQLLGAGNRPQAALLARE
                     RGWI"
     gene            complement(5618..7105)
                     /locus_tag="H181DRAFT_RS09680"
                     /old_locus_tag="H181DRAFT_01951"
     CDS             complement(5618..7105)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1222: dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006604054.1"
                     /locus_tag="H181DRAFT_RS09680"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="H181DRAFT_01951"
                     /product="NAD(P)/FAD-dependent oxidoreductase"
                     /protein_id="WP_045863853.1"
                     /transl_table=11
                     /translation="MTSDVAVVGTGPNGLAAAVTMARAGLSVELYEAAGTIGGGLRGEA
                     FFDSGIRHDVCSAVHPMAAASPFFREFQLPERGVELLNPPVAYAHALDDGRAGLAYGDL
                     DTTCEVLGKDGPAWRRLMAPLLEHSTGLVDFFMSGQRSVPRDLLAPLLLAARLPAHGTR
                     LGSRAGSPGSRLLGGFREDVAPALLAGVAAHAVGKLPSLASASVAMLLGHLAHGPGWPL
                     PRGGSERIAEVMADDIRAHGGTFHTSARVTDLRQFDGVRAVLLDTDPTQLLEMAGDRLP
                     AGYARHLRRYRYGPGAAKADFLVSGPVPWTNPELGRAGTVHLGGTREAVARQEGLTVRG
                     ERTDEPFVLLVDPAVTDPGRARDGKRPVWAYAHVPNGDPRDPVELLRTRIEKYAPGFSD
                     TVIAARGIPAGEYEKYNANYVGGDIGAGAMTLYQSVARPVPYLDPHRTPLPGVFLCSAS
                     TPPGPGVHGMSGYLAARSALRHRFGMREAPSLGPGRA"
     gene            complement(7102..9039)
                     /locus_tag="H181DRAFT_RS09685"
                     /old_locus_tag="H181DRAFT_01952"
     CDS             complement(7102..9039)
                     /EC_number="7.-.-.-"
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003991974.1"
                     /locus_tag="H181DRAFT_RS09685"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="H181DRAFT_01952"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_074467788.1"
                     /transl_table=11
                     /translation="MSTLEAKASSRTLHVEGQDDRIGPAHARRRGGGPGPAAVWYLARR
                     HRALLATGIVVGLIGVTAQLAQPYAIGELIKQAGQNKPLSAAIILLVALFCVDGAFSAL
                     QSYLIGRAGENIVYDVRMLLTRRLLRVDLSAYGKQQQGDVLTRTVADTSLAKIALSQSL
                     AQLVINGFTVAGGVIVMFLIDVWMMLITLACLGIASAISLFLARSVRRAAMVNREDTSQ
                     YGSDVQRALSALPTVKASRAEDRETHRIGLLAWKARNSGVRVNGLNALFMPAMNVGTQA
                     ALAVVVGVGMTRVTRGTMSMADLTAFVMYLFYMVSPLVLFFLAIGQFQQGRAAIRRVDE
                     LTVLPQEGGVLDRMRHKSKPAPAKKSLSADKEAVEFRDVRFSYGGGEDGAETLSDVTFS
                     VASRGMTAIVGPSGAGKTTLFQLVERFHALDGGAILVGGKDIETMPLSTLRGLVGYVQQ
                     DTAAMRGTIRENVVYAEPDASDEQIREVLELAGLTKVVDAMPDGLDTELGDQGSGLSGG
                     QRQRLCIARALLQKPAVLLLDEATSHLDSDSEREFRETLSKVTSRCAVIAIAHRISTVV
                     DADKIVVMADGRVQDSGKHDELMKRSALYHRLANSQLQAAHTMTKAPAQVPQPAHAGPV
                     STVDTAENTL"
     gene            complement(9050..9805)
                     /locus_tag="H181DRAFT_RS09690"
                     /old_locus_tag="H181DRAFT_01953"
     CDS             complement(9050..9805)
                     /EC_number="2.1.1.-"
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1248: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013005800.1"
                     /locus_tag="H181DRAFT_RS09690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="H181DRAFT_01953"
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_045863854.1"
                     /transl_table=11
                     /translation="MTSVDDVGYGRQFGGFYDRIFPSGPYTEPTVAKLAALHPAPGERA
                     LELGVGTGRVAIPLAQRAFPVTGVDSSPEMLEQLTTKAKEADADVEAVHGDIRKYTDDN
                     QYKLVYCICATFSMLLDPDDQRAAIQCAADRLAPGGMLVVETSNAGGVRALHEGQQRTS
                     YFLPYPEPNTGLLTYSTLLDNGLWHASHIWFEDGKSSIGSELARLTTPDEVDAYAQAAG
                     LRPADRWADWKETPWAEDSPMFVSTYTRN"
     gene            complement(10001..10705)
                     /locus_tag="H181DRAFT_RS09695"
                     /old_locus_tag="H181DRAFT_01955"
     CDS             complement(10001..10705)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     linaridin: cypI"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007453462.1"
                     /locus_tag="H181DRAFT_RS09695"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="H181DRAFT_01955"
                     /product="hypothetical protein"
                     /protein_id="WP_074467789.1"
                     /sec_met_domain="cypI (E-value: 2.1e-33, bitscore: 110.4,
                     seeds: 22, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSSQTPASLAGTVTRTARGTRSVLARAFTGPGGLTRAAGAAVLL
                     GTLSAQHPNPLFNRAQKIDIFSVLFPNWRFFAPTPAQHDYHILYRTLDHDGETSPWKMV
                     EVIVGRKLHQMFWFPGRRPEKAIFDIVTELITQLDKGFGALKKLPSYRMLCAFLRHRLQ
                     EEGKADDVKGFQFTLVRATGYEENDPEVIFVSPYTPMAVESEPAAAARSSRPSYEAHIR
                     DDSREEVPVQPA"
     gene            complement(10702..12609)
                     /locus_tag="H181DRAFT_RS09700"
                     /old_locus_tag="H181DRAFT_01956"
     CDS             complement(10702..12609)
                     /NRPS_PKS="Domain: Thioesterase (348-480). E-value:
                     3.6e-11. Score: 35.9. Matches aSDomain:
                     nrpspksdomains_H181DRAFT_RS09700_Thioesterase.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Thioesterase"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1036: alpha/beta hydrolase fold protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019435953.1"
                     /locus_tag="H181DRAFT_RS09700"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="H181DRAFT_01956"
                     /product="alpha/beta fold hydrolase"
                     /protein_id="WP_078895619.1"
                     /sec_met_domain="Thioesterase (E-value: 1.9e-11, bitscore:
                     39.4, seeds: 16, tool: rule-based-clusters)"
                     /sec_met_domain="PF00561 (E-value: 1e-08, bitscore: 29.9,
                     seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 4.2e-16, bitscore:
                     55.1, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKSLAKKLTSTFLGPVPISRDRTLAISERLTAVTSLTSSIEYITH
                     QRQIRRGGLNDWTIARGMHAASTRPTRRILDAVGHPRTTQALHIARIAAGAALLAPGNA
                     RWRGAANMFLGLSNAALYPRHRYGTDGSDQVSSFVQTAAGMARLSTQPAVQDALLWYVA
                     LQANLSYLVSGWVKLLGQPWRDGSALNGIMRTRTYGHEGLWKLTNRYPVPARYLAHGVL
                     ALECLFPVAYLKGGALARPIMASAAAFHVANGYFMGLGRFITAFEAMHPMVAYTSAPKS
                     HPAVAGRDDRALTATASMAAIGITIAGFLAAMRRMRATDPWPHGRVLTTRHGNELHYNE
                     RVSENEKAPVLVFGTGMTSTAEHFGWITEKLVEDSDYGIITYSRAGYGPSKHRSPAPYS
                     LQESVDDLVDLVRGAVNEGRDVYLVGHSLGGELARRAARELGDRVNGVIYLDSSHPEEL
                     NRSKQQKESAERLKDGLNMFTRSLRAGMGAMLVRPRWVHNLPAEVRSRAFAQYADSRLW
                     RAGMREWDATERDFKAFEGDLPSVGGHALVLSAQRTVDRDPEQLLMHNELAAAHRGDGR
                     IVRNSVLEGADHDTMLTDARLGTDVGRRILDFLHEVEAKEGGAGRSGSGAEGNKSEEAR
                     "
     aSDomain        complement(11170..11565)
                     /aSDomain="Thioesterase"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_H181DRAFT_RS09700_Thioesterase.1
                     "
                     /evalue="3.60E-11"
                     /label="H181DRAFT_RS09700_Thioesterase.1"
                     /locus_tag="H181DRAFT_RS09700"
                     /protein_end="480"
                     /protein_start="348"
                     /score="35.9"
                     /tool="antismash"
                     /translation="PVLVFGTGMTSTAEHFGWITEKLVEDSDYGIITYSRAGYGPSKHR
                     SPAPYSLQESVDDLVDLVRGAVNEGRDVYLVGHSLGGELARRAARELGDRVNGVIYLDS
                     SHPEELNRSKQQKESAERLKDGLNMFTR"
     CDS_motif       complement(11290..11349)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_H181DRAFT_RS09700_0001"
                     /evalue="3.50E-04"
                     /label="NRPS-te1"
                     /locus_tag="H181DRAFT_RS09700"
                     /protein_end="440"
                     /protein_start="420"
                     /score="13.2"
                     /tool="antismash"
                     /translation="VYLVGHSLGGELARRAAREL"
     misc_feature    12594..12608
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.37"
                     /tool="antismash"
     misc_feature    complement(12596..12607)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 15.96"
                     /tool="antismash"
     misc_feature    12692..12705
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 13.68"
                     /tool="antismash"
     misc_feature    complement(12714..12723)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: strong, score: 17.48"
                     /tool="antismash"
     gene            complement(12857..13027)
                     /locus_tag="H181DRAFT_RS29360"
                     /old_locus_tag="H181DRAFT_01957"
     CDS             complement(12857..13027)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="H181DRAFT_RS29360"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="H181DRAFT_01957"
                     /product="hypothetical protein"
                     /protein_id="WP_158715428.1"
                     /transl_table=11
                     /translation="MNDITSHINESAELAAVDAEGAIFADNTPVLATPGAFLGGVAIAS
                     ATVAAFEAGQG"
     gene            complement(13108..13281)
                     /locus_tag="H181DRAFT_RS29365"
                     /old_locus_tag="H181DRAFT_01958"
     CDS             complement(13108..13281)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="H181DRAFT_RS29365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="H181DRAFT_01958"
                     /product="hypothetical protein"
                     /protein_id="WP_158715429.1"
                     /transl_table=11
                     /translation="MLEAKLNLQIQDELHEGHDGEIAEEATPVLATPALAGAFVGGAAV
                     VTGAYAAGKAVG"
     misc_feature    13567..13582
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: medium, score: 21.73"
                     /tool="antismash"
     misc_feature    complement(13666..13682)
                     /note="TFBS match to NuR, Nickel-responsive regulator,
                     confidence: weak, score: 22.63"
                     /tool="antismash"
     misc_feature    complement(13667..13681)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.65"
                     /tool="antismash"
     misc_feature    complement(13686..13702)
                     /note="TFBS match to NuR, Nickel-responsive regulator,
                     confidence: weak, score: 20.45"
                     /tool="antismash"
     gene            complement(13791..14447)
                     /locus_tag="H181DRAFT_RS09705"
                     /old_locus_tag="H181DRAFT_01959"
     CDS             complement(13791..14447)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018488431.1"
                     /locus_tag="H181DRAFT_RS09705"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="H181DRAFT_01959"
                     /product="DNA-binding response regulator"
                     /protein_id="WP_045864004.1"
                     /transl_table=11
                     /translation="MPESGSGGGSEAGGDTRPIRVLLADDEHLIRGALAALLALEGDLT
                     IVAEAASGPEALAMARAHEPDVAVLDLQMPGADGVKVATQLRDSLPSCRIMIVTSHARP
                     GHLKRALAVGVRGFVPKTASAQQLAEIIRAVHRGVRYVDPELAADAISAGDSPLTAREA
                     ELLGLAADGAPVAEIAERASLTAGTVRNYLSAATAKLGAENRHTAARIARERGWL"
     gene            complement(14459..15772)
                     /locus_tag="H181DRAFT_RS09710"
                     /old_locus_tag="H181DRAFT_01960"
     CDS             complement(14459..15772)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0000155 - phosphorelay sensor kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0046983 - protein dimerization activity
                     [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1048: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018547482.1"
                     /locus_tag="H181DRAFT_RS09710"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="H181DRAFT_01960"
                     /product="sensor histidine kinase"
                     /protein_id="WP_045863855.1"
                     /transl_table=11
                     /translation="MRRAGKVIGWWLNPGYRRWQERSSTEQVEASTRWMLIAYAWVILA
                     GFVVQLLPNTAPGRLPFSLACAVLAMGLVQCLLCTALLHQALDSYLGTRPLPRARFGLP
                     TLLLGAVTALTVALVALGAVEGGVTVGLALYGALAPFAVTFGITVPRRTAALVLCGYVA
                     VTAGSLAAAGMPWTNVLAAAAVMAAGGLISVFTGRSSAWYIAVIRELEEARGVQARLAV
                     AEERLRFSRDLHDVMGRNLSAIALKSELAAQLVRRGAPADASVEQMSEVQSIARDSQSE
                     VRAVVRGYRDADLSTELAGARGILRAAGVDCRAKSDDAPLPGPVQAALGWVVREGATNV
                     LRHADATWCTVWVGSDAAGNKALLVMENDGVHRAARDPEGGRTGSGLAGLRERLAGVGG
                     TLRSAGDSGKGTFRLTAEVPIGSPADDAQGAGGKETAE"
     gene            complement(15805..16620)
                     /locus_tag="H181DRAFT_RS09715"
                     /old_locus_tag="H181DRAFT_01961"
     CDS             complement(15805..16620)
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009716224.1"
                     /locus_tag="H181DRAFT_RS09715"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="H181DRAFT_01961"
                     /product="ABC transporter permease"
                     /protein_id="WP_045863856.1"
                     /transl_table=11
                     /translation="MTATQAAPANTPGTKMNTSSAGRRMASLGRAELTLLFRNKAALFV
                     ALATPILLTLLMRQTASGMNLDGTGLSLGTVLVPGSIGYVLIFAVYANLTGAYVTRREE
                     LVLKRLRTGEASDSEILAGAALPSVVLGVLQCVLLLVGGAALMDLGAPERPELVAAGVI
                     LGMVMMVGLAAVSAAFTRTTEASQITTFPVIAISAVGSGIVIPLDVFPDTLGEICSLLP
                     VSPVMELVRGGWAGTLDGPDSLKALGVAVLWIVLSLLAVHKWFPWEPRR"
     gene            complement(16617..17603)
                     /locus_tag="H181DRAFT_RS09720"
                     /old_locus_tag="H181DRAFT_01962"
     CDS             complement(16617..17603)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019355073.1"
                     /locus_tag="H181DRAFT_RS09720"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="H181DRAFT_01962"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_045863857.1"
                     /transl_table=11
                     /translation="MDAIEVEGLKRRYSKGFEAVRGVSFSVREGEIFALLGTNGAGKTS
                     TVELLEGLAKPSGGKVRVLGFDPYSERRAVRPRTGVMLQEGGFPSELTVTETVRMWAGC
                     TSDARPIGDALAQVGLSGRRADVRVKQLSGGERRRLDLAMALIGRPEVLFLDEPTTGMD
                     PEGRRDTWELVRELRTAGTTVLLTTHYLEEAEALADRLAIMRAGRIVTAGTHEQVVAER
                     PSRIRFTLPEGLTPAGLPPTLSPAELNGNRIEIRTPSLQSELTDLLMWARQSGVELQNL
                     HARTATLEEVFLEIAQEPEEDDAAPAGAGGHAGHGGTAPEQKEVERV"
     tRNA            complement(17815..17887)
                     /anticodon=(pos:complement(431476..431478),aa:Gly,seq:gcc)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="H181DRAFT_RS09725"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /old_locus_tag="H181DRAFT_01963"
                     /product="tRNA-Gly"
     gene            complement(17815..17887)
                     /locus_tag="H181DRAFT_RS09725"
                     /old_locus_tag="H181DRAFT_01963"
     misc_feature    complement(17952..17967)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 17.68"
                     /tool="antismash"
     tRNA            complement(17962..18033)
                     /anticodon=(pos:complement(431623..431625),aa:Gly,seq:tcc)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="H181DRAFT_RS09730"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /product="tRNA-Gly"
     gene            complement(17962..18033)
                     /locus_tag="H181DRAFT_RS09730"
     gene            complement(18138..18455)
                     /locus_tag="H181DRAFT_RS09735"
                     /old_locus_tag="H181DRAFT_01964"
     CDS             complement(18138..18455)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009189439.1"
                     /locus_tag="H181DRAFT_RS09735"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="H181DRAFT_01964"
                     /product="Lsr2 family protein"
                     /protein_id="WP_074467800.1"
                     /transl_table=11
                     /translation="MAQRVVVTLSDDLDGGEASETVSFGLDGKSYEVDLNLDNAKKLRE
                     DLARFVEAGRKRAKSGKTYHRTSVAPDPRAVRAWAESNGFEVPARGRIPKKIYDAFNAS
                     R"
     misc_feature    18568..18584
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 16.79"
                     /tool="antismash"
     misc_feature    18645..18660
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 20.06"
                     /tool="antismash"
     misc_feature    18656..18671
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 19.2"
                     /tool="antismash"
     gene            18911..19204
                     /gene="purS"
                     /locus_tag="H181DRAFT_RS09740"
                     /old_locus_tag="H181DRAFT_01965"
     CDS             18911..19204
                     /EC_number="6.3.5.3"
                     /codon_start=1
                     /gene="purS"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014136948.1"
                     /locus_tag="H181DRAFT_RS09740"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="H181DRAFT_01965"
                     /product="phosphoribosylformylglycinamidine synthase
                     subunit PurS"
                     /protein_id="WP_045863859.1"
                     /transl_table=11
                     /translation="MARVVVDVMLKPEILDPQGQAVQRALPRLGFEGIADVRQGKRFEL
                     EVAEPVSDETLARLHELAEKFLANTVIENFTVRVEDGGTSGGASGDARGAVA"
     gene            19201..19887
                     /gene="purQ"
                     /locus_tag="H181DRAFT_RS09745"
                     /old_locus_tag="H181DRAFT_01966"
     CDS             19201..19887
                     /EC_number="3.5.1.2"
                     /EC_number="6.3.5.3"
                     /GO_function="GO:0004642 -
                     phosphoribosylformylglycinamidine synthase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006189 - 'de novo' IMP biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /gene="purQ"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019547974.1"
                     /locus_tag="H181DRAFT_RS09745"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="H181DRAFT_01966"
                     /product="phosphoribosylformylglycinamidine synthase
                     subunit PurQ"
                     /protein_id="WP_045863860.1"
                     /transl_table=11
                     /translation="MTGGLGRIGVVTFPGSLDDRDAQRAVRLAGGEPVALWHREKDLRQ
                     VDAVVLPGGFSYGDYLRCGAIARFSPVMEPLLEQARAGMPVLGICNGFQVLCESHLLPG
                     ALTRNDHLHFVCRDQRLRVERADTAWTGDYEQGQEITVPLKNGEGGYVADERTLDALEA
                     EGRVVFRYAGGNPNGSRRDIAGITNEAGNVVGLMPHPEHAVETLTGPTTDGLGFFTSVL
                     KRLVTA"
ORIGIN
        1 ctcggcctgc gcttcgcggg cggatgcgcc cgcctcatgc tccgcgcctg cgtgccgcac
       61 gccgccgaga tggagcgcgg cgtggccgcg gcggcggccc accgtgcaca gggtgtggac
      121 cacgcgctgc gtacgtccgc ccaggagcag gtcggtctcg cctacgccgg ctgggaccgc
      181 ctcctgacgc gtgtcgcgct gcccgcctgg cgcatcggcc ggtggcccgc ccggctggac
      241 gccggcgtgg tctccgccct gacggagctc tcgcaccggg acagcctcgc ggggggcttc
      301 acctcccgcc tcggggagcg gcccgcctgc gacctgctcg actcccccgg cgcggtcgac
      361 gagtcgatct cgctgctggc ggcccgcctc ttccacggcg gcccggccga gtccgggccc
      421 gactggtctc cggtggactg gcaggagtac ccggaggagg tcgtcgaccg catatggcgc
      481 acccatgccg cccgtctctt cgccgagctc gacgtgctgg acgggcccgg cgccgtcggt
      541 gccggacggg tcggggcgga cggcgcgggg gctctcccgg ggcccacgct gtcccgcgtc
      601 atggagcggc tggcggggag cgagggggcg gacggggagg cgctggccgc ccggatagcg
      661 gccgcggtcg cccgtgagga ggcggagaac gcgggggagg ccgcgctcgt ggcgccgctc
      721 gtggccgccg tgggcggcac gggggcggcg gcgcccatgg ggttgccgct gcagcctccc
      781 cgcggcgggc gcgaggtcat gacggagcac gtcaccgcgg tcgtctgctg tgcggcggtg
      841 gacacggccg gtgcggtcgc cggtctggac tggctcgacg gcccggcgct cttcgtcggc
      901 ggggagcgcg cggcggatct cagcggtccc gtgctcgcgc tcgtcgagga ggcggacgtc
      961 cagccgctga gggactggct ggcgagggtc ggcgtccgag cggacaagcc ggtccggctc
     1021 gtctgagccg tctgttccga acggcccgct tccgtagccg tcccgaggcg ggccgcctgc
     1081 gtccgggacg gcggcccccg gctgccgctc cggcgcgaac gcctcgcagg accgcctgcg
     1141 ccgcccgcgc tggtacgcct gtccgagacc gagtgcttgt atcggccaaa tgagcgacca
     1201 agggtgatgt cgcgctcgcg taatgtgatg ggctgaagcc gcgggggcga caaatgtgga
     1261 ctggggagtc acaggtgggg accgaagaca tccggcactg ggagtcgggg gcgctcgcgc
     1321 acgcggccac cgacccgttc ggccaggggc cgctcccctg gctccggttc ggcgagcagt
     1381 acttcgacaa cggccgcatg gtgccctggt acgtggacca gacggggctg gagggcctcc
     1441 tccccggcga gtccctcagc cagcccggag tgggccgccc caggaccgcc gacgacgtgc
     1501 actgccagat caaggggttc gccggaagcg acggcggcac cgcgccgggg gactccctgg
     1561 acttccggat caccgtcgac cctccccagg ccttcgccgt cgacgtctac cgcgtcggcc
     1621 attacggcgg catcggcgcg acgaagatca ccacgagtcc ccgtctgtcc ggcatccggc
     1681 agcccccgcc cctgaccgcc gaccgcaccg tctcctgcca caactggtgg ctctcctggc
     1741 ggctccaggt cccctcccac tggtcgacgg gcgcctatgt ggcggttctc accaccgcgg
     1801 acggacggca ccgctcccac atccccttca ccgtccgcga ccgcgacccc gcggatctgc
     1861 tggtcgtcct ccccgacctc acctggcagg cgtacaacct cttccccgag aacggccgcg
     1921 acggtgccag cctctaccac gcctgggacg accacggacg cctgctcggc gaggaggacg
     1981 ccgccgtcac cgtctccttc gaccgcccct acgcgggtgc cggcctcccc ctgcacatcg
     2041 gccacgccta cgacttcatc cgctgggccg aacgcgtcgg ctacgacctg gcgtacgccg
     2101 acgcccgcga cgtccacgcg ggccgcgtgg atctcgccgc ccaccgcgga gtgatcttcc
     2161 cggggcacga cgagtactgg tcggtgccca tgcggcgctc cgtcgaacgg gcccgtgacg
     2221 gcggcacctc gctcgtcttc ctctccgcca acaccatgta ctggcaggtg gacttggacc
     2281 cgctgcccgg cgggtcgccg gaccggctgc tgacctgccg caagcgccgg ggccccggcc
     2341 ggtcggccca gtggcgctcc cagggcgagc cggagcagca catcctgggc gtccagtacg
     2401 cgggccaggt cccggagccg tacccgctga tcgtgcgcaa cagcgaacac tggctgtggg
     2461 aggggacgga ggcgggtgac ggcgacggga tcccgggtct cgtggccggc gaggccgacc
     2521 gctacttccc ccgtacgagc ctcccggagt acaccgagcg cgtcctgctc gcccattccc
     2581 cgtaccagga cacgggcggt gcgcgccgcc atcaggagac gtcgctgtac cgggcgccgt
     2641 ccggcgcgct ggtcttctgc tccggcacct tcgcctggac gcccgcgctg gaccggccag
     2701 gccacgtcga ctcccgcgtg cagcgggcga cggccaacct gctggaccgc gtgtgcaaaa
     2761 gcgactgacc gccgcggccg tgcacaccgc ggctgtgcac accgcggctg tgcacaccgc
     2821 ggctgtgcac accgcggccg tgcacaccgc ggccttgggc gccccgggtg cgcacggccg
     2881 gtcgtcgctc ccgcggcccg gcggctgccc gctccttccc tgaccggacc gccccggagt
     2941 gtgtgcgaga gcccgtacgg gacaatcggt atccggagcc gtgccaaccc ccggaggagc
     3001 agtgtccgga ttcgtcgaga agcccgagcc agtgcaggtg ccgggcctgc tgcatctgca
     3061 caccggcaag gtgcgcgacc tgtaccggaa cgaggcgggc gacctggtga tggtggccag
     3121 tgaccgcgtc tcggcgtacg actgggtgct tcccaccgag attcccgaca agggccggat
     3181 cctcacgcag ctctcgctgt ggtggttcga gcagctggcg gacctcgtgc cgaaccacgt
     3241 gatcagcacc gaggttccgg ccggcgcccc cgccgactgg gaagggcgca cgacggtgtg
     3301 ccgttcgctg cgcatgatcc cggtcgagtg cgtcgcgcgc ggttacctga cgggctcggg
     3361 cctcgcggag tacgagcagg ctcgcacggt ctgcgggctc gcgctccccg aaggcctcac
     3421 cgacggttcg gagttgcccg gcccgatctt cacacccgcc acgaaggccg ccgtcggcga
     3481 ccacgacgag aacgtcagct acgaggaggt cgcgcgcgag gtgggtgcgg agaccgccgc
     3541 ccagctgcgg cagttgaccc tcgcggtcta ccagcgggcg cgtgacgtgg ccctcgaccg
     3601 cggcatcatc ctcgccgaca cgaagctgga gttcggtcac ggtacgggcg cggacgacgg
     3661 catcggcgtc cccgccgaga accacgtcgg cctcttcctc ggcgacgagg tgctcacccc
     3721 cgactcgtcc cgtttctggc cggccgacca gtggcagccg ggccgcccgc agccgtcgtt
     3781 cgacaagcag ttcgtccgcg actggctgtc cggcgccgat tccggctggg accggaacgg
     3841 tcaactcccg cccccgccgc tgccggagaa gatcgtggag cagacgcggg cgaagtacgt
     3901 ggaggcctac agccggctga cgggcctcga ctgggcctga gggcacgtcg ttcggatctt
     3961 cgtcgggccc gcgccgccca gcacgcccga ctgctgcact gtcggagccg cccgggtacg
     4021 ccccgtacga gggcgctcct ccgcctggcg tccgggcgca cccggggcgc cgcccaaggc
     4081 cgttccgtcg cacgagaagg ggtcccggtc gggaagaccg ggaccccttc tcgtgtgcac
     4141 accgcgtgtg cacggccgag cggacgacga ggttcgaact cgcgacctca accttggcaa
     4201 ggttgcgctc taccagctga gctacgtccg caggagccga ccggatcctg ctcgatccgt
     4261 gcggctcggt gcccactata aaccaaacac agaaccggct tagcggagtc gaatcttccg
     4321 atggggaggg tgcatacggg ggcagaagcg caccacacga cggcctgcca ggaattgccc
     4381 ccggtccgag gggtgttgga agccttcgtt ttttctatgc tcggattcct gttcaggctc
     4441 gtgggacaca aagctttgac gaccacccac tgcacgggcc cagcaggcga ccgaagtggg
     4501 ggagatcagc ttgagtacca acgagatgtc ctatctcggt ctcaccgagg aacaggagca
     4561 gatctaccgg ctgtgcctcc gcgagccggg gatcgggatc gacggactga tagagcagct
     4621 ccggctgacg ccgcacgcgg cgcgcgagga gctcggccgg ctgcgcgagt tggggctgct
     4681 gcgaggtggc ggaacgccgg agcaggaggc cgggagcggc acggcggagg aggacgggct
     4741 ggccgccgcc gatccggacg tggcggtggc gcgcctgctg gacctccgcc tccacgaact
     4801 gcacgagaag ctgcagcagg tcaccgagct tcagccgctg gtggcttcgc tccgcccgga
     4861 gagcgcggcg cagcagccgc cgaccgtggt gggcatcgag cagatcaccg atccgcccaa
     4921 gatccgtgac cgcgtcgacg acttggcctt cttcgcccgc gaagaggtct ccctggtgga
     4981 gccggcgacg gcgcttcggc cggaggacat cgagcaggac cggccgcggg tgctccgctg
     5041 cctgcgcagg gggctgagcg tccgcacggt cctcgtccgc aaggccctgg accacgcccc
     5101 gacggtctcc tacctgcggg aactggagtc ccacggagcg cgggtgcggc tggtcagcca
     5161 caccacggcg aagatccaga tgtacgaccg ccgcaccgcc gtcgtgcccg tccaccccga
     5221 agacagctcg cgcggtgcgc tgttcgcgca ggagagcggc ctcgtctcca acattctcgc
     5281 catgttcgag tcgatttggg cggagtcgga cgacctcggc gccctgctcg gggagcgccg
     5341 gtccgaaggc gagaacggtc cgtccgaact ggagcggatg gtcctgcggg cgatgtgctc
     5401 cgggggcaag gacgaggcgg gggcccgcga tctgggcgtc tcggtccgta cgtacaggcg
     5461 ctacatcgcc gatctcatgc agctgctcgg cgcgggcaac cgtccgcagg cggcgctgct
     5521 cgcccgtgaa cgcggctgga tctgaccccc ggcgccgggg agcgggcgca gaaggacggg
     5581 gtgccggact tcggtccggc cgccggaccc gtcgccgtca cgcccgtccg ggacccagcg
     5641 acggtgcctc gcgcatcccg aatcggtgcc gcagcgcgga gcgggcggcc agatacccgg
     5701 acatgccgtg cacgcccggg ccgggcggtg tggacgccga gcagaggaag acgcccggca
     5761 gcggcgtgcg gtgcgggtcc aggtagggca ccggacgggc caccgactgg tagagcgtca
     5821 tggcgcccgc tccgatgtcg ccgcccacgt agttcgcgtt gtacttctcg tactcgcctg
     5881 cggggatgcc gcgcgcggcg atgacggtgt cgctgaaccc cggcgcgtac ttctcgatgc
     5941 gggtacgcag cagttcgacg gggtcgcgag gatcgccgtt gggtacatgg gcgtacgccc
     6001 acacgggcct cttcccgtca cgtgcccgcc cgggatcggt gacggccggg tcgacgagca
     6061 ggacgaaggg ctcgtcggtg cgttcgcccc gcacggtcag cccttcctgc cgtgcgacgg
     6121 cttcacgcgt cccgcccagg tggacggttc ccgcccgtcc gagttccggg ttcgtccacg
     6181 ggacgggccc ggagacgagg aagtcggcct tggcggcgcc ggggccgtac cggtaccgcc
     6241 tcaagtgccg ggcgtagccg gcgggaagcc ggtcccccgc catctccagc agctgggtgg
     6301 ggtcggtgtc gagcagcacg gcgcgtacgc cgtcgaactg ccgcaggtcg gtgacgcggg
     6361 ccgaggtgtg gaacgtcccg ccgtgcgcgc ggatgtcgtc ggccatcacc tcggcgatgc
     6421 gctcgctgcc gccgcggggc aggggccagc ccggaccgtg cgcgaggtgc cccagcagca
     6481 tcgcgaccga agcggacgcc aggctcggca gcttgccgac ggcgtgcgcg gcgacgcccg
     6541 ccagcagagc cggggccacg tcctcgcgga agccgccgag gaggcggctg ccgggcgagc
     6601 cggcccgcga gccgagccgg gtgccgtgcg cgggcagccg cgctgcgagc agcagcggcg
     6661 cgaggaggtc acggggcacg gaccgctggc cgctcatgaa gaagtcgacc aggccggtgc
     6721 tgtgttcgag gagcggagcc atcaggcgcc gccaggcggg cccgtccttc ccgaggactt
     6781 cgcaggtggt gtccagatcg ccgtaggcca gccccgcgcg tccgtcgtcc agggcgtgcg
     6841 cgtacgcgac gggcggattg agcagctcca cgccgcgctc cgggagctgg aactcgcgga
     6901 agaagggcga cgcggcggcc atcgggtgca cggcggagca cacgtcgtgg cggatgccgc
     6961 tgtcgaagaa cgcctcgccg cgcagcccgc ccccgatggt cccggccgct tcgtacagtt
     7021 cgacgctcag tccggcgcgt gccatggtca ccgcggcggc gaggccgttc gggccggtgc
     7081 cgacgacggc cacatcggat gtcacagagt gttctccgcc gtgtccacgg tgctcacggg
     7141 acccgcgtgc gccggctgcg gcacctgcgc gggggccttc gtcatggtgt gcgccgcctg
     7201 gagctgggag ttggccagcc ggtggtacag cgcgctccgc ttcatcagtt cgtcgtgctt
     7261 gccggagtcc tgcacccggc cgtcggccat gacgacgatc ttgtccgcgt cgacgacggt
     7321 cgagatgcgg tgcgcgatcg cgatgacggc acagcgcgag gtgaccttgc tgagcgtctc
     7381 gcggaactcc cgctcggagt cggagtccag gtgggaggtg gcctcgtcga ggaggagcac
     7441 ggcgggcttc tgcagcagtg cgcgcgcgat gcacaggcgc tgccgctgac cgccggagag
     7501 gccgctgccc tggtcgccga gttcggtgtc caggccgtcc ggcatcgcgt cgacgacctt
     7561 ggtgagaccc gccagttcga ggacttcgcg gatctgctcg tcgctcgcgt ccggctcggc
     7621 gtacacgacg ttctcgcgga tggtgccgcg catcgccgcg gtgtcctgct ggacgtaccc
     7681 gaccaggccg cgcagcgtgc tcagcggcat cgtctcgatg tccttgccgc cgacgaggat
     7741 cgctccgccg tcgagcgcgt ggaagcgctc cacgagctgg aagagcgtgg tcttgcccgc
     7801 tcccgacggg ccgacgatgg ccgtcatccc gcgcgacgcc accgagaagg tcacgtcgct
     7861 gagcgtctcc gcgccgtcct ccccgccgcc gtagctgaag cggacgtcgc ggaactccac
     7921 ggcctccttg tccgccgaca gcgacttctt ggccggtgcg ggcttcgact tgtgccgcat
     7981 cctgtccagg acgccgccct cctgcgggag gacggtgagc tcgtcgaccc tgcggatcgc
     8041 ggcgcgcccc tgctggaact gcccgatggc gaggaagaac aggacgagcg gggagaccat
     8101 gtagaagagg tacatcacga acgcggtgag gtcggccatc gacatcgtgc cgcgggtcac
     8161 ccgcgtcatg ccgacgccga cgacgacggc gagcgccgcc tgcgtcccca cgttcatcgc
     8221 cggcatgaac agcgcgttga gtccgttgac gcgcacgccc gagttgcggg ccttccacgc
     8281 cagcaggcct atccggtgcg tctcgcggtc ctccgcgcgg gacgccttca ccgtcggcag
     8341 ggccgacagc gcgcgctgca cgtccgagcc gtactggctg gtgtcctcgc ggttgaccat
     8401 cgcggcgcgg cgcacgctgc gcgccaggaa gagggagatc gcgctggcga tgccgaggca
     8461 ggccagggtg atcagcatca tccacacgtc gatcaggaac atcacgatga cgccgccggc
     8521 caccgtgaag ccgttgatga ccagttgggc gaggctctgc gagagcgcga tcttcgccag
     8581 cgaggtgtcg gcgacggtgc gggtgaggac gtcgccctgc tgctgcttgc cgtacgcgga
     8641 caggtcgacg cgcagcagcc gtctggtgag cagcatccgc acgtcgtaga cgatgttctc
     8701 gcccgcccgg ccgatgaggt acgactgcag cgccgagaac gcgccgtcca cgcagaacag
     8761 cgcgacgaga aggatgatcg ccgccgagag cggcttgttc tgcccggcct gcttgatcag
     8821 ttcaccgatc gcgtagggct gagcgagctg cgccgtgacg ccgatcagcc ctacgacgat
     8881 gccggtggcc aggagcgccc tgtggcgccg tgcgagatac cagacggcgg ctggtcccgg
     8941 accgccgccg cgcctgcgcg cgtgcgccgg tccgatccgg tcgtcctgac cctccacgtg
     9001 gagggtcctg gaactcgcct tcgcctccag ggtgctcatg gcgctcacct caattgcggg
     9061 tgtaggtgct gacgaacatg ggggagtcct cggcccaggg ggtctccttc cagtccgccc
     9121 agcggtccgc cggccgcaga ccggcggcct gggcgtacgc gtccacctcg tccggcgtcg
     9181 tgagccttgc cagttcggat ccgatggacg acttgccgtc ctcgaaccag atgtgcgaag
     9241 cgtgccacag gccgttgtcg aggagggtcg aatacgtcag cagccccgtg ttcggctcgg
     9301 ggtacgggag gaagtacgag gtgcgctgct ggccttcgtg cagcgcccgt acaccgcccg
     9361 cgttggaggt ctccaccacg agcatgccgc cgggcgcgag gcggtcggca gcacactgga
     9421 tggcggcgcg ctggtcgtcg gggtcgagca gcatcgagaa ggtcgcgcag atgcagtaga
     9481 cgagcttgta ctggttgtcg tcggtgtact tgcggatgtc gccgtgcacc gcctcgacgt
     9541 cggcgtcggc ctccttcgcc ttcgtcgtca gctgctccag catctcgggc gacgagtcga
     9601 cgcccgtgac ggggaaggcc cgctgggcga gcggaatcgc cacccgcccc gtgccgacgc
     9661 cgagttcgag cgcccgctcg ccgggtgcgg ggtgcagggc ggcgagcttc gcgacggtcg
     9721 gctcggtgta gggaccgctc gggaagatcc tgtcgtagaa gccgccgaac tggcgtccgt
     9781 aacctacgtc gtccacggaa gtcatcgggg cctcctctcg gtctcgttgg gggcggcgga
     9841 ctacttcttc ttcttggcga ggttcagcgc gaggtatccg gcgatgacga tgccgatgac
     9901 ggcgatgacg atcgatgcgg tggacatgtg acccctttcg ggaatccggt tgtggttcac
     9961 ccgtccccac aggttcgcgg gacggacagt cggtgctcgg tcaggcaggc tgtacgggca
    10021 cttcctcgcg ggagtcgtcc cgtatgtgcg cttcgtagga gggccgggag ctgcgtgccg
    10081 ccgcggcggg ttccgactcg acggccatgg gggtgtaggg cgagacgaag atgacctcgg
    10141 ggtcgttctc ctcgtagccg gtggccctga cgagggtgaa ctggaagccc ttcacgtcgt
    10201 ccgccttgcc ctcctcctga agccggtggc ggaggaacgc gcagagcatc ctgtaggagg
    10261 gcagcttctt cagcgcgccg aagcccttgt ccagctgcgt gatcagctcg gtgacgatgt
    10321 cgaagatcgc cttctcggga cgccggcccg ggaaccagaa catctggtgc agcttccggc
    10381 cgacgatgac ctcgaccatc ttccacgggg aggtctcccc gtcgtggtcc agggtccggt
    10441 acaggatgtg gtagtcgtgc tgggccggag tcggcgcgaa gaagcgccag ttggggaaga
    10501 gcaccgagaa gatgtcgatc ttctgcgccc tgttgaacag ggggttcggg tgctgcgcgg
    10561 agagcgtgcc cagcagcacc gcggcgccgg cggcgcgggt gaggccgccc ggaccggtga
    10621 aggcgcgggc gagcaccgac cgggtgccgc gggccgtacg ggtcaccgtt ccggccagcg
    10681 atgcgggagt ctgcgagctg gtcatcgtgc ctcctcggac ttgttcccct cggcgccgga
    10741 cccgctgcgt cccgcgccgc cttccttcgc ttcgacctcg tggaggaagt cgaggatgcg
    10801 gcgccccacg tcggtgccga gccgggcgtc ggtgagcatt gtgtcgtggt cggcgccctc
    10861 cagcaccgag ttgcggacga tgcgcccgtc ccctcggtgc gcggcggcca gttcgttgtg
    10921 catcagcagc tgttccgggt cgcggtcgac ggtccgctgc gcggagagca ccagcgcatg
    10981 gcccccgacg gagggcagat cgccctcgaa tgccttgaag tcgcgctcgg tggcgtccca
    11041 ttcgcgcatg ccggcgcgcc acagccggct gtccgcgtac tgcgcgaagg cgcggctgcg
    11101 gacctcggca ggcaggttgt gcacccagcg gggacgtacc agcatcgcgc ccatgcccgc
    11161 ccgcaggctg cgcgtgaaca tgttcaggcc gtccttgagg cgctccgcgg attccttctg
    11221 ctgcttggag cggttcagct cctccgggtg cgaactgtcc aggtagatga cgccgttgac
    11281 ccggtcgccg agctcccgcg cggcgcggcg ggcgagttca ccgccgagcg aatgccccac
    11341 gaggtacacg tcccgtccct cgttcacggc gccgcggacc aggtccacca ggtcgtccac
    11401 ggactcctgg aggctgtacg gggcggggct gcggtgcttg ctcggcccgt agccggcgcg
    11461 gctgtaggtg atgatgccgt agtcgctgtc ctcgacgagc ttctccgtga tccagccgaa
    11521 gtgctcggcg gtggaggtca tcccggtgcc gaagacgagg acgggtgcct tctcgttctc
    11581 cgagacccgc tcgttgtagt ggagttcgtt gccgtgccgg gtggtgagga cgcggccgtg
    11641 cggccagggg tcggtggccc gcatccggcg catcgcggcg aggaacccgg cgatcgtgat
    11701 gccgatggcc gccatcgacg ccgtcgcggt cagcgccctg tcgtcccgtc cggccaccgc
    11761 cgggtgcgac ttgggtgcgc tggtgtacgc gaccatcggg tgcatcgcct cgaaggcggt
    11821 gatgaaccgg cccaggccca tgaagtagcc gttggccacg tggaacgccg ccgcactggc
    11881 catgatcggg cgggcgaggg ctccgccctt gaggtacgcc accgggaaga ggcactccag
    11941 cgcgagcacg ccgtgcgcga ggtagcgggc gggcaccggg tagcggttgg tgagcttcca
    12001 caggccctcg tgcccgtacg tacgcgtgcg catgatgccg ttgagcgcgg atccgtcccg
    12061 ccacggctgc cccagcagct tcacccagcc ggagacgagg taggagaggt tcgcctgcag
    12121 tgcgacgtac cacaacaggg cgtcctgcac ggcgggttgg gtggagagcc gggccattcc
    12181 cgcggccgtc tgcacgaacg acgacacctg gtcggagccg tccgtgccgt agcggtggcg
    12241 cgggtagagg gcggcgttgc tgagcccgag gaacatgttc gcggcacctc gccagcgggc
    12301 gttgcccggt gcgaggagcg ccgcgcccgc cgcgatacgg gcgatgtgca gtgcctgcgt
    12361 ggtgcggggg tggccgacgg cgtccagaat gcggcgggtg ggccgcgtgg aggcggcgtg
    12421 catgccgcgg gcgatcgtcc agtcgttgag cccgccgcgg cgtatctgcc gctggtgggt
    12481 gatgtattcg atgctggagg tgagtgacgt gactgccgtg aggcgctcgg agattgcgag
    12541 cgtgcggtca cgggagatcg ggaccggccc gagaaatgtc gaggtcagct ttttggcaag
    12601 cgatttcacg tcggtctcct cggtgccggt gtcccgggtg cgggtggtgg tctgaaatgt
    12661 gggggatttg gcaagaggcg tggtgcggca aatatggcga aaaaacagag tggtcaaaaa
    12721 ttaaaagaaa ccggataacg ggggatccgg tcggccggtt ttgcggccgg ccgaccggga
    12781 ggagagtccc cttgtttcac gctgacttgt agaagggggt actacacgac ggcgtgagcg
    12841 aggagagggg ctgaaatcag ccctggcccg cctcgaaggc cgcgaccgtc gccgaagcga
    12901 tggcgacgcc gcccaggaag gcacccgggg tggcgagcac gggggtgttg tccgcgaaga
    12961 tggcaccctc ggcgtcgacg gcggcgagct cggccgactc gttgatgtgc gaagtgatgt
    13021 cgttcatgcg cacactcctg ttcttggtga agtcttgcga cgggattccg gccgcaggta
    13081 ggaattcggc cggcggttgg gcgatggtca gccgacagcc ttgccggccg cgtaggcgcc
    13141 ggtcacgacg gcggcgccgc cgacgaaggc accggcgagg gcgggggtgg cgagaaccgg
    13201 ggtggcctct tccgcgatct caccgtcgtg gccctcgtgg agctcgtcct gaatctgaag
    13261 gttcagcttc gcttccagca tggaattcct cctgtgcgtg taagacatgg ctggctgtgg
    13321 ttcgcgaaag tgggtctaag ccaggaaggc ccggattggt cgtcgggcac catttccccc
    13381 gttcggtgag ctttcggtcg tcaccgtaaa ctgcagcgaa gcgggcatct atgcgcacgc
    13441 ttacctctcc gtgaatgcct gactcgcttc cgcagggatg aagatgccag cacggggcgg
    13501 ggcgcagaag aggaatccgt gacagtttgt tgcaaggcga cgcgacagct tcatgccacg
    13561 gatggtaaag gactggacca gttcgttact gggcagtggg cgttttccag ttccctgagc
    13621 tgtaagctca agtaaacctc agaatcttga aattggcacc agcggttgca agggatattc
    13681 agggatagcg agggatatcc aagtccgcag tggttgcgcc ctcttcagcc tcgtggggcg
    13741 aactcgtccg agttcgtccc cgcaccgccc ggtgcgtacg gtccgtgccg ttacagccag
    13801 ccccgctccc gcgcgatgcg tgcggccgtg tgcctgttct cggcacccag cttcgccgtg
    13861 gccgccgaca ggtagttgcg gaccgtgccc gccgtgagcg aggcccgctc cgcgatctcc
    13921 gcgacgggcg cgccgtccgc ggcgagaccg agcagctccg cctcccgtgc cgtcagcggg
    13981 gagtcgccgg cgctgatcgc gtccgccgcc agctccgggt cgacgtaccg cactccgcgg
    14041 tggacggccc ggatgatctc cgcgagctgc tgcgccgacg cggtcttcgg cacgaagccc
    14101 cgtacgccga cggcgagggc ccgcttgaga tggccgggcc gcgcatggct ggtgacgatc
    14161 ataatcctgc acgacggcag cgagtcacgg agctgggtcg cgaccttcac accatccgcg
    14221 cctggcatct gcaggtcgag caccgcgacg tccggttcgt gggcccgggc catcgcgagc
    14281 gcctcgggac cggacgccgc ctcggcgacg atggtcaggt cgccctccag cgcgagcaga
    14341 gcggccagcg caccgcggat caggtgctcg tcgtcggcga gaaggacgcg gataggacgc
    14401 gtgtccccgc ccgcctcact cccaccgccg gatccggact ccggcagatc ctccgcgctc
    14461 actccgctgt ttccttcccg cccgcgccct gggcgtcgtc cgcagggctg ccgatcggga
    14521 cctccgccgt cagccggaac gtacctttcc cgctgtcccc ggcggaacgc aaggtgcctc
    14581 ccacaccggc gagacgttca cgcagacccg cgagccccga accggtgcgc ccgccctccg
    14641 ggtcgcgggc ggcgcggtgc acgccgtcgt tctccatcac gagcagtgcc ttgttcccgg
    14701 ccgcgtccga gccgacccac accgtgcacc acgtggcgtc cgcgtgccgc agcacgttcg
    14761 tggcgccctc gcgcacgacc cagccgagcg ccgcctggac cgggccgggc agcggggcgt
    14821 cgtcgctctt ggcgcggcag tcgactcctg cggcacgcag gatgccgcga gcaccggcga
    14881 gttcggtgga gaggtccgcg tcgcggtacc cgcgcaccac cgcgcggact tcggactgcg
    14941 agtcgcgggc gatgctctgg acctccgaca tctgctcgac cgacgcgtcc gccggcgccc
    15001 cgcgccgcac cagctgcgcc gccagttcgc tcttgagcgc gatcgcggag aggttccgcc
    15061 ccatcacgtc gtgcagatcg cggctgaagc gcagccgctc ctcggcgacc gccagccgcg
    15121 cctgcacacc gcgcgcctcc tccagctccc ggatgacggc gatgtaccag gcggacgagc
    15181 ggccggtgaa cacggagatc agtccgccgg cggccatcac cgccgctgcc gccagcacgt
    15241 tcgtccaggg catcccggcg gcggccagcg agcccgcggt gacggcgacg tagccgcaga
    15301 ggaccagcgc cgcggtccgg cgcggaacgg tgatgccgaa cgtcaccgcg aagggggcga
    15361 gggcgccgta cagcgccagg cccacggtca ccccgccctc gacggcgccg agggcgacga
    15421 gcgccaccgt gagcgcggtg acggccccca gcagcagcgt cggcagtccg aagcgggccc
    15481 ggggcagggg gcgcgtgccc aggtagctgt cgagggcctg gtgcagaagt gccgtacaca
    15541 gcaggcactg caccaggccc atcgcgagta ccgcgcacgc gagggagaag ggcaggcgac
    15601 cgggagcggt gttgggcagc agctgcacga cgaagcccgc caggatcacc cacgcgtacg
    15661 cgatgagcat ccaccgcgtc gacgcttcga cctgctcggt gctgctgcgc tcctgccacc
    15721 ggcggtatcc ggggttcaac caccagccga tcaccttgcc ggctctcctc accggagcgc
    15781 cttccggggc tccgcctcgt ccgtctatcg cctgggctcc caagggaacc acttgtgcac
    15841 ggccagcaac gacagcacga tccacagcac cgcgacgccc agcgccttca gcgagtccgg
    15901 accgtccagc gtgcccgccc agccgccgcg caccagctcc atgaccgggg agacgggcag
    15961 cagcgagcag atctccccga gagtgtcggg gaagacgtcg agcgggatca cgatgccgga
    16021 gcccaccgcc gagatcgcga tcaccgggaa ggtcgtgatc tgcgacgcct cggtggtgcg
    16081 cgtgaacgcg gcggagaccg cggccagccc gaccatcatc accatgccca ggatcacacc
    16141 cgcggcgacg agttcgggac gctcgggtgc gccgaggtcc atcagggcgg ccccgccgac
    16201 gagcagcagg acgcactgca gcacgcccag gacgacggac ggcagcgccg cgcccgccag
    16261 gatctcgctg tcgctcgcct cgcccgtccg cagccgcttg aggacgagct cctcgcgacg
    16321 ggtcacgtac gcgcccgtca ggttggcgta gacggcgaag atcagcacgt agccgatgga
    16381 gccggggacg aggacggtgc ccagcgagag accggtgccg tccaggttca tgccgctggc
    16441 cgtctggcgc atcaggagcg tcagcaggat cggggtggcg agcgcgacga agagcgccgc
    16501 cttgttgcgg aacagcagcg tcagttcggc ccgtccgagc gaggccatcc gccgtccggc
    16561 cgacgaggtg ttcatcttgg tgcccggcgt gttcgccggg gcggcctgtg tcgcggtcat
    16621 acccgctcca cctccttctg ctccggcgcc gtcccgccgt ggcccgcgtg gccgccggct
    16681 ccggccggcg ccgcgtcgtc ctcttccggc tcctgggcga tctccaggaa gacctcctcc
    16741 agcgtcgcgg tgcgcgcgtg gaggttctgc agctcgacgc cgctctggcg ggcccacatc
    16801 agcaggtcgg tcagctcgct ctgcaggctg ggcgtgcgga tctcgatacg gttcccgttc
    16861 agttcggcgg gcgacagcgt cggcggcagc ccggccggcg tgaggccctc cggcagcgtg
    16921 aagcggatac gggacggccg ctccgcgacg acctgctcgt gcgtgccggc ggtgacgatg
    16981 cggccggcgc gcatgatggc gagccggtcg gcgagggctt ccgcctcttc caggtagtgg
    17041 gtggtcagca gcacggtggt gccggcggtg cgcagctcgc gcaccaactc ccaggtgtcc
    17101 cggcgtcctt cggggtccat gccggtggtc ggctcgtcca ggaagagcac ctcggggcgc
    17161 cctatgagag ccatcgccag gtccaggcgc ctgcgttcac cgccggagag ctgcttcacg
    17221 cgtacgtccg cgcgccgccc ggagagcccg acctgggcca gcgcgtcgcc gatgggccgc
    17281 gcgtcgctcg tgcagcccgc ccacatccgc accgtctcgg tgacggtcaa ctcggagggg
    17341 aagccgccct cctgcagcat cacacccgta cgcggccgca cggcgcgacg ttcggagtag
    17401 ggatcgaagc cgagcacgcg gaccttccct ccgctcggct tcgccagtcc ttccagcagt
    17461 tcgaccgtgg aggtcttgcc tgcgccgttc gtccccagca gcgcgaagat ctccccttcc
    17521 cggacggaga aggagactcc gcgtacggct tcgaacccct ttgagtatcg ccgtttgagt
    17581 ccttcgacct cgatcgcatc catggcgtca tccttccgcg cgaacgaggt cccggggcgt
    17641 gttcgctgtc acaagtgcgg atgacgaacg tcatgggagg accatgcgct tcgcacaaag
    17701 gggcagtgcg ggacggaccg cgaaaccggt ggaggcggag cggaggggaa ccggaccgca
    17761 aggcccggga agacgaatag gccccggtgg gaaccggggc ctattcctga acggagcgga
    17821 cgacgaggtt cgaactcgcg acctcaacct tggcaaggtt gcgctctacc agctgagcta
    17881 cgtccgcatg cctccacccg gcgttcaccg agtggcgcgt ccttcactgt acccgatgga
    17941 taccggggcc ggtgaagaaa gagcgggtga caggaatcgc acactgcgcc tcccccttgg
    18001 aaagggggcg ctctactact gagctacacc cgcgtgatcc ggaaggttcc ccttcgcggt
    18061 gcgccagact ctagcggatc acccggggtg catggcaagt cgggccgccc ggcccgccgt
    18121 acgggccggg cgcgggttca gcgggaggcg ttgaaggcgt cgtagatctt cttcgggatg
    18181 cgcccgcggg ccggcacctc gaacccgttc gattcggccc aggcccgtac cgcgcggggg
    18241 tcgggggcca cggaggtgcg gtggtaggtc ttgcccgatt tggcccgctt gcggccggcc
    18301 tccacaaagc gtgcgaggtc ttcccgcagt ttcttcgcgt tgtcgaggtt gaggtcgacc
    18361 tcgtacgact tcccgtcgag tccgaaggag accgtttctg atgcttcccc gccgtcgaga
    18421 tcgtcggaga gtgtcaccac tacgcgttgc gccacggata tcggaccttc catcaggatc
    18481 gcgaaatgga tcactcggct cttctccggg gcccgcatgc gaagaccctg ggggaacgta
    18541 agtggtccga aggattgggg tcggtgtctt tatcttttgt acagcggcat gctttgcaat
    18601 gtgaagcgag agtatttcga ctcgcgtgtc agaccgcaat cgcgaccata cttttttcac
    18661 tgcttttttc ccagagctgc gactcgtccg cccggaacgg cggggagagt cgaaagctgg
    18721 cggcatccca tatcaacgcg cgtagaatct cgggaccggt aggcttgcgg aggcgtcacc
    18781 acgtcgttga cgtcgttcgg cgccgtccgg gtgttgttcg acgtgcggcg gggcgccggc
    18841 actcacagag gcgtgaggca ccgctcggcg gcgcccgcct cgagcaccac caccatcacc
    18901 gggagtacct gtggctcgcg tcgtagtcga cgtcatgctg aagccggaga tcctcgatcc
    18961 gcagggacag gcggtgcagc gcgcactgcc ccgtctcggt ttcgagggca tcgccgacgt
    19021 ccgccagggc aagcgattcg aactcgaggt ggcggagccc gtctcggacg agacgctggc
    19081 ccgcctccac gaactggcgg agaagttcct ggcgaacacc gtgatcgaga acttcaccgt
    19141 ccgcgtcgag gacggcggaa cctccggcgg cgcttccggg gacgcgcggg gagccgtggc
    19201 gtgaccgggg ggctcggccg catcggcgtc gtcaccttcc ccggttccct cgacgacagg
    19261 gacgctcagc gggccgtgcg cctcgcgggc ggcgagcccg tcgcgctgtg gcaccgcgag
    19321 aaggacctgc ggcaggtgga cgccgtcgtg cttcccggcg gcttctccta cggcgactac
    19381 ctgcgctgcg gcgccatcgc ccgcttctcc ccggtgatgg agcccctgct ggagcaggcg
    19441 cgtgccggca tgcccgtcct gggcatctgc aacggcttcc aggtgctgtg cgagtcgcac
    19501 ctgctgcccg gcgccctgac ccgcaacgac cacctgcact tcgtctgccg cgaccagagg
    19561 ctgcgggtcg agcgcgcgga caccgcctgg acgggcgact acgagcaggg gcaggagatc
    19621 accgtcccgc tcaagaacgg cgagggcggc tacgtcgccg acgagcgcac gctggacgcc
    19681 ctggaggccg agggccgcgt cgtcttccgc tacgccggcg gcaaccccaa cggctcgcgc
    19741 cgcgacatcg ccggcatcac caacgaggcc gggaacgtgg tcggcctcat gccgcacccc
    19801 gagcacgccg tcgagaccct gaccggtccg acgaccgacg ggctgggctt cttcacctcg
    19861 gtactcaaga ggctggtcac cgcatgacgc gcacgacacc cgcacagcgc cccgtcctcg
    19921 acaccgtcga gcacgcctcc ggcactcccg ggacggacca gccgtgggcc gaactcggcc
    19981 tcaaggagga cgagtacgcg cgtatccgcg acatcctggg gcgccgcccc acgggtgccg
    20041 agctggccat gtactcggtg atgtggtcgg agcactgctc gtacaagagc agcaaggtgc
    20101 acctgaagca gttcggcgag aaggcgcccg agtcggacgc gctgctcgtc ggcatcggcg
    20161 agaacgccgg cgtcgtcgac atcggccagg actacgcggt caccttcaag gtcgagtcgc
    20221 acaaccaccc cagctacgtc gagccctacc agggtgcggc caccggcatc ggcgggatcg
    20281 tccgcgacat cctcgccatg ggcgcgcgcc ccgtcgcggt catggacccg ctgcgcttcg
    20341 gggcccccga ccaccccgac accaggaggg tgctgcccgg tgtcgtcgcc ggcatcggcg
    20401 gctacggcaa ctgcctcggc ctgcccaaca tcgggggcga gaccgtcttc gacccctgct
    20461 accaggggaa cccgctggtc aacgccttgt gcgtgggtgt gatgaagcac gaggacatcc
    20521 acctggcgca agcgtcgggc accggcaaca aggtcatcct ctacggcgcc cgcaccgggg
    20581 gcgacggcat cggcggcgtc tccgtcctcg cgtcggagac cttcgacgag gaggggcccg
    20641 ccaagcggcc cgccgtccag gtcggcgacc cgttccagga gaagctgctc atcgagtgca
    20701 ccctg
//
