Select genomic region:
Overview
4.1
4.2
4.3
4.4
4.5
4.6
4.7
4.8
4.9
4.10
4.11
4.12

### Identified secondary metabolite regions using strictness 'relaxed'

NZ_LT575476.1 (Paenibacillus tuaregi)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 4.1 | RRE-containing | 204,605 | 225,984 |
Region 4.2 | lanthipeptide-class-ii | 435,027 | 461,398 |
Region 4.3 | proteusin | 1,073,505 | 1,093,756 | Low | bacillibactin/bacillibactin E/bacillibactin F | NRPS:Type I
Region 4.4 | terpene-precursor | 2,154,709 | 2,175,584 |  |
Region 4.5 | T3PKS | 2,554,851 | 2,596,008 |
Region 4.6 | NRPS,T1PKS | 2,828,009 | 2,914,400 | Low | N-myristoyl-D-asparagine/cis-7-tetradecenoyl-D-asparagine/(R)-N1-((S)-5-oxohexan-2-yl)-2-tetradecanamidosuccinamide/colibactin/precolibactin 1489 | NRPS:Type I+PKS:Type I
Region 4.7 | NI-siderophore | 2,915,656 | 2,947,253 | Low | staphyloferrin B | other:other
Region 4.8 | transAT-PKS,NRPS | 3,023,223 | 3,091,221 |
Region 4.9 | cyclic-lactone-autoinducer | 3,763,404 | 3,783,934 |
Region 4.10 | ranthipeptide | 3,895,135 | 3,916,423 |
Region 4.11 | RRE-containing | 4,037,317 | 4,058,921 |
Region 4.12 | phosphonate | 4,203,608 | 4,216,776 |

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 4.1 | RRE-containing | 204,605 | 225,984 |
Region 4.2 | lanthipeptide-class-ii | 435,027 | 461,398 |
Region 4.3 | proteusin | 1,073,505 | 1,093,756 | Low | bacillibactin/bacillibactin E/bacillibactin F | NRPS:Type I
Region 4.4 | terpene-precursor | 2,154,709 | 2,175,584 |  |
Region 4.5 | T3PKS | 2,554,851 | 2,596,008 |
Region 4.6 | NRPS,T1PKS | 2,828,009 | 2,914,400 | Low | N-myristoyl-D-asparagine/cis-7-tetradecenoyl-D-asparagine/(R)-N1-((S)-5-oxohexan-2-yl)-2-tetradecanamidosuccinamide/colibactin/precolibactin 1489 | NRPS:Type I+PKS:Type I
Region 4.7 | NI-siderophore | 2,915,656 | 2,947,253 | Low | staphyloferrin B | other:other
Region 4.8 | transAT-PKS,NRPS | 3,023,223 | 3,091,221 |
Region 4.9 | cyclic-lactone-autoinducer | 3,763,404 | 3,783,934 |
Region 4.10 | ranthipeptide | 3,895,135 | 3,916,423 |
Region 4.11 | RRE-containing | 4,037,317 | 4,058,921 |
Region 4.12 | phosphonate | 4,203,608 | 4,216,776 |

No secondary metabolite regions were found in these records:
  NZ_LT575473.1 (Paenibacillus tuaregi)
  NZ_LT575474.1 (Paenibacillus tuaregi)
  NZ_LT575475.1 (Paenibacillus tuaregi)

Compact view
NZ_LT575476.1 - Region 1 - RRE-containing
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 204,605 - 225,984 nt. (total: 21,380 nt) Show pHMM detection rules used
RRE-containing: minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE])

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
No tailoring functions detected.
Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | RRE-containing | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002306.2 |  | 0.48 | ribosomal | freyrasin | Paenibacillus polymyxa ATCC 842
BGC0001887.3 |  | 0.40 | ribosomal | huazacin | Bacillus thuringiensis serovar huazhongensis BGSC 4BD1
BGC0000572.5 |  | 0.36 | ribosomal | capistruin | Burkholderia thailandensis E444
BGC0000504.5 |  | 0.35 | ribosomal | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1
BGC0002260.3 |  | 0.35 | terpene | trichobrasilenol, xylarenic acid B, brasilane A, brasilane F, brasilane E, brasilane D | Annulohypoxylon truncatum
BGC0002698.2 |  | 0.34 | ribosomal | phaeornamide | Pseudophaeobacter arcticus DSM 23566
BGC0000518.3 |  | 0.34 | ribosomal | informatipeptin | Streptomyces viridochromogenes DSM 40736
BGC0000599.5 |  | 0.34 | ribosomal | thuricin CD α, thuricin CD β | Bacillus thuringiensis
BGC0000600.3 |  | 0.33 | ribosomal | thurincin H | Bacillus thuringiensis
BGC0000581.6 |  | 0.33 | ribosomal | microcin J25 | Escherichia coli AY25

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002306.2 |  | 0.48 | ribosomal | freyrasin | Paenibacillus polymyxa ATCC 842
BGC0001887.3 |  | 0.40 | ribosomal | huazacin | Bacillus thuringiensis serovar huazhongensis BGSC 4BD1
BGC0000572.5 |  | 0.36 | ribosomal | capistruin | Burkholderia thailandensis E444
BGC0000504.5 |  | 0.35 | ribosomal | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1
BGC0002260.3 |  | 0.35 | terpene | trichobrasilenol, xylarenic acid B, brasilane A, brasilane F, brasilane E, brasilane D | Annulohypoxylon truncatum
BGC0002698.2 |  | 0.34 | ribosomal | phaeornamide | Pseudophaeobacter arcticus DSM 23566
BGC0000518.3 |  | 0.34 | ribosomal | informatipeptin | Streptomyces viridochromogenes DSM 40736
BGC0000599.5 |  | 0.34 | ribosomal | thuricin CD α, thuricin CD β | Bacillus thuringiensis
BGC0000600.3 |  | 0.33 | ribosomal | thurincin H | Bacillus thuringiensis
BGC0000581.6 |  | 0.33 | ribosomal | microcin J25 | Escherichia coli AY25

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
CRP
Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 18.06 out of 19.26
Confidence: strong
MexT
Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 18.58 out of 21.84
Confidence: medium
VqsM
Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 18.42 out of 20.47
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 23.47 out of 28.19
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 20.98 out of 28.19
Confidence: medium
Additional weak hits (6):
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 23.02 out of 31.73
Confidence: weak
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 23.32 out of 31.73
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.76 out of 26.06
Confidence: weak
NrtR
Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 22.46 out of 35.63
Confidence: weak
LexA variant 1
Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 20.94 out of 29.65
Confidence: weak
ZuR variant 2
Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 24.77 out of 33.14
Confidence: weak
RREFinder
TFBS Finder
RRE predictions
RREfinder results sidepanel.

RRE-containing protocluster (204604...225984)
BN6628_RS01385
  RRE type: Other_Sactipeptide_rSAM_RRE
  Location: 3 - 93
  Score: 35.0

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CRP | Cyclic AMP receptor protein
MexT | Global virulence regulator
VqsM | Regulator of quorum-sensing signalling systems
ZuR variant 1 | Zinc-responsive repressor

NZ_LT575476.1 - Region 2 - lanthipeptide-class-ii
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 435,027 - 461,398 nt. (total: 26,372 nt) Show pHMM detection rules used
lanthipeptide-class-ii: cds(LANC_like and DUF4135)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Lanthipeptides
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Lyases: cyclase
BN6628_RS02290: lanthionine synthetase C family protein

smcogs
  SMCOG1070: lanthionine synthetase C family protein

BN6628_RS02300: lanthionine synthetase C family protein

smcogs
  SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | lanthipeptide-class-ii | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000517.4 |  | 0.57 | ribosomal | haloduracin β, haloduracin α | Bacillus halodurans C-125
BGC0000552.3 |  | 0.54 | ribosomal | SmbA, SmbB | Streptococcus mutans
BGC0000623.3 |  | 0.54 | ribosomal | plantaricin W α, plantaricin W β | Lactobacillus plantarum
BGC0000525.5 |  | 0.54 | ribosomal | lichenicidin VK21 A1, lichenicidin VK21 A2 | Bacillus licheniformis
BGC0001391.3 |  | 0.53 | ribosomal | thusin | Bacillus thuringiensis serovar rongseni
BGC0001311.5 |  | 0.53 | ribosomal | flavecins | Ruminococcus flavefaciens FD-1
BGC0001229.4 |  | 0.53 | ribosomal | SBI-06990 A1, SBI-06989 A2 | Streptomyces bingchenggensis BCW-1
BGC0002663.2 |  | 0.52 | ribosomal | amyloliquecidin GF610 | Bacillus amyloliquefaciens UMAF6639
BGC0002110.3 |  | 0.52 | ribosomal | birimositide | Streptomyces rimosus subsp. rimosus WC-3908
BGC0001555.4 |  | 0.52 | ribosomal | colicin V | Escherichia coli chi7122

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000517.4 |  | 0.57 | ribosomal | haloduracin β, haloduracin α | Bacillus halodurans C-125
BGC0000552.3 |  | 0.54 | ribosomal | SmbA, SmbB | Streptococcus mutans
BGC0000623.3 |  | 0.54 | ribosomal | plantaricin W α, plantaricin W β | Lactobacillus plantarum
BGC0000525.5 |  | 0.54 | ribosomal | lichenicidin VK21 A1, lichenicidin VK21 A2 | Bacillus licheniformis
BGC0001391.3 |  | 0.53 | ribosomal | thusin | Bacillus thuringiensis serovar rongseni
BGC0001311.5 |  | 0.53 | ribosomal | flavecins | Ruminococcus flavefaciens FD-1
BGC0001229.4 |  | 0.53 | ribosomal | SBI-06990 A1, SBI-06989 A2 | Streptomyces bingchenggensis BCW-1
BGC0002663.2 |  | 0.52 | ribosomal | amyloliquecidin GF610 | Bacillus amyloliquefaciens UMAF6639
BGC0002110.3 |  | 0.52 | ribosomal | birimositide | Streptomyces rimosus subsp. rimosus WC-3908
BGC0001555.4 |  | 0.52 | ribosomal | colicin V | Escherichia coli chi7122

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Lanthipeptide predictions
Shows the possible core peptides for each biosynthetic enzyme.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.

#### Lanthipeptide(s) for BN6628_RS02290

BN6628_RS02285
Leader:
MKMAVLKNPVLRNKIGYEGENPSGNVLEEIKDHDVVGA
Core:
I S W G T V L T T L A C L G A S Y A L G D K G Q V C T A T V E C I N N C R K
Core with dehydrations:
I Dha W G Dhb V L Dhb Dhb L A Cys L G A Dha Y A L G D K G Q V Cys Dhb A Dhb V E Cys I N N Cys R K

#### antiSMASH-DB 4.0 matches for BN6628_RS02285

100.0%
NZ_LT575476.1 and 1 other:
NZ_LT575476.1 Lanthipeptides: BN6628_RS02285_lanthipeptide
Lanthipeptides: BN6628_RS02285_lanthipeptide
1
I S W G T V L T T L A C L G A S Y A L G D K G Q V C T A T V E C I N N C R K
38
I S W G T V L T T L A C L G A S Y A L G D K G Q V C T A T V E C I N N C R K
1
I S W G T V L T T L A C L G A S Y A L G D K G Q V C T A T V E C I N N C R K
38
78.9%
NZ_JAQFWW010000002.1 and 1 other:
NZ_JAQFWW010000002.1 Lanthipeptides: PDT38_RS11330_lanthipeptide
Lanthipeptides: PDT38_RS11330_lanthipeptide
1
I S W G T V L T T L A C L G A S Y A L G D K G Q V C T A T V E C I N N C R K
38
I S W G T+L T T L+C L A S +G D K G Q V C T T V E C N N C R K
1
I S W G T L L T T L S C L A A S I M I G D K G Q V C T G T V E C Q N N C R K
38
57.9%
NZ_CP116355.1 and 1 other:
NZ_CP116355.1 Lanthipeptides: KPP03845_RS17815_lanthipeptide
Lanthipeptides: KPP03845_RS17815_lanthipeptide
3
W G T V L T T L A C L G A S Y A L G D K G Q V C T A T V E C I N N C R
37
W G T V+++L+C G A S Y L G+ G C T A T E C N N C+
4
W G T V M S S L S C Y G A S Y V L G N N G N F C T A T A E C Q N N C K
38
with 102 more sequence matches
Only the first 10 are displayed here.
55.3%
NZ_BMRY01000003.1 and 24 others:
NZ_BMRY01000003.1 Lanthipeptides: IE140_RS12370_lanthipeptide NZ_BMSZ01000006.1 Lanthipeptides: IE135_RS12780_lanthipeptide NZ_BMSZ01000006.1 Lanthipeptides: IE135_RS12780_lanthipeptide NZ_BNBJ01000003.1 Lanthipeptides: IE304_RS05285_lanthipeptide NZ_BNBJ01000003.1 Lanthipeptides: IE304_RS05285_lanthipeptide NZ_CP021707.1 Lanthipeptides: CCZ36_RS18205_lanthipeptide NZ_CP079114.1 Lanthipeptides: KV381_RS19425_lanthipeptide NZ_CP079114.1 Lanthipeptides: KV381_RS19425_lanthipeptide NZ_CP084357.1 Lanthipeptides: LEL86_RS34965_lanthipeptide NZ_CP084357.1 Lanthipeptides: LEL86_RS34965_lanthipeptide NZ_JALDPQ010000054.1 Lanthipeptides: MQC87_RS11020_lanthipeptide NZ_JALDPQ010000054.1 Lanthipeptides: MQC87_RS11020_lanthipeptide NZ_JAMFLF010000021.1 Lanthipeptides: M1212_RS32880_lanthipeptide NZ_JAMFLF010000021.1 Lanthipeptides: M1212_RS32880_lanthipeptide NZ_JNLT01000014.1 Lanthipeptides: CD02_RS38630_lanthipeptide NZ_JNLT01000014.1 Lanthipeptides: CD02_RS38630_lanthipeptide NZ_JNZV01000231.1 Lanthipeptides: BG84_RS0100145_lanthipeptide NZ_JNZV01000231.1 Lanthipeptides: BG84_RS0100145_lanthipeptide NZ_KZ819178.1 Lanthipeptides: DBP20_RS18455_lanthipeptide NZ_KZ819178.1 Lanthipeptides: DBP20_RS18455_lanthipeptide NZ_LZRD01000017.1 Lanthipeptides: A3Q37_RS19720_lanthipeptide NZ_LZRD01000017.1 Lanthipeptides: A3Q37_RS19720_lanthipeptide NZ_NNBN01000001.1 Lanthipeptides: CG717_RS03735_lanthipeptide NZ_NNBN01000001.1 Lanthipeptides: CG717_RS03735_lanthipeptide
Lanthipeptides: IE140_RS12370_lanthipeptide
3
W G T V L T T L A C L G A S Y A L G D K G Q V C T A T V E C I N N C R
37
W G T++++L+C G A S Y L G+ G C T A T E C N N C+
4
W G T I V S S L S C Y G A S Y V L G N N G N F C T A T A E C Q N N C K
38
55.3%
NZ_QKTG01000020.1 and 1 other:
NZ_QKTG01000020.1 Lanthipeptides: DEI99_RS16920_lanthipeptide
Lanthipeptides: DEI99_RS16920_lanthipeptide
4
G T V L T T L A C L G A S Y A L G D K G Q V C T A T V E C I N N C R
37
G T +T T L+C G S+A L G+ G C T A T V E C +N C+
4
G T T V T T L S C Y G V S W A L G N D G N F C T A T V E C Q S N C K
37
55.3%
NZ_WHOM01000078.1 and 1 other:
NZ_WHOM01000078.1 Lanthipeptides: GCN81_RS29300_lanthipeptide
Lanthipeptides: GCN81_RS29300_lanthipeptide
3
W G T V L T T L A C L G A S Y A L G D K G Q V C T A T V E C I N N C R
37
W G T L++L+C G A S Y L G+ G C T A T E C +N C+
4
W G T T L S S L S C Y G A S Y V L G N N G N F C T A T A E C Q S N C Q
38
53.8%
NZ_JALGRP010000007.1 and 1 other:
NZ_JALGRP010000007.1 Lanthipeptides: MT347_RS12955_lanthipeptide
Lanthipeptides: MT347_RS12955_lanthipeptide
3
W G T V L T T L A C L G A S Y A L G D K G Q V C T A T V E C I N N C R
37
W T +T+L C G S+ G+ G Q V C T A T V E C N N C
5
W T T T I T S L T C Y G V S W V A G N N G Q V C T A T V E C Q N N C N
39
50.0%
NZ_JALIRS010000003.1 and 3 others:
NZ_JALIRS010000003.1 Lanthipeptides: MOK21_RS07255_lanthipeptide NZ_JALNLQ010000002.1 Lanthipeptides: MWJ95_RS06810_lanthipeptide NZ_JALNLQ010000002.1 Lanthipeptides: MWJ95_RS06810_lanthipeptide
Lanthipeptides: MOK21_RS07255_lanthipeptide
5
T V L T T L A C L G A S Y A L G D K G Q V C T A T V E C I N N C
36
T+L T+L A C A S Y L G+ G V C T T V E C C
8
T I L T S L A C A A A S Y I L G N P G H V C T L T V E C Q K K C
39
47.4%
NC_017299.1 and 1 other:
NC_017299.1 Lanthipeptides: H04402_RS03105_lanthipeptide
Lanthipeptides: H04402_RS03105_lanthipeptide
1
I S W G T V L T T L A C L G A S Y A L G D K G Q V C T A T V E C I N N C
36
S G T+ T L S +G+ G+V C T T V E C N N C
2
F S E G T I S I T L-----S V Y M G N D G K V C T W T V E C Q N N C
32
47.4%
NZ_BQXZ01000001.1 and 1 other:
NZ_BQXZ01000001.1 Lanthipeptides: OCU69_RS05000_lanthipeptide
Lanthipeptides: OCU69_RS05000_lanthipeptide
1
I S W G T V L T T L A C L G A S Y A L G D K G Q V C T A T V E C I N N C R K
38
S G T+ T L S +G+K G V C T T+E C +N C K
2
F S G G T I S I T L-----S V Y M G N K G S V C T W T I E C Q S N C S K
34
47.4%
NZ_CM000756.1 and 7 others:
NZ_CM000756.1 Lanthipeptides: BTHUR0011_RS34475_lanthipeptide NZ_CP031749.1 Lanthipeptides: DPQ26_RS30450_lanthipeptide NZ_CP031749.1 Lanthipeptides: DPQ26_RS30450_lanthipeptide NZ_CP036071.1 Lanthipeptides: EXW41_RS29770_lanthipeptide NZ_CP036071.1 Lanthipeptides: EXW41_RS29770_lanthipeptide NZ_WBPC01000036.1 Lanthipeptides: F8159_RS30260_lanthipeptide NZ_WBPC01000036.1 Lanthipeptides: F8159_RS30260_lanthipeptide
Lanthipeptides: BTHUR0011_RS34475_lanthipeptide
2
S W G T V L T T L A C L G A S Y A L G D K G Q V C T A T V E C I N N C R
37
+W T T+ + + S G+K G+V C T T V E C+N N C R
3
T W N T T A T S T S I I-I S E T F G N K G K V C T Y T V E C V N N C R
37
47.4%
NZ_CP086141.1 and 1 other:
NZ_CP086141.1 Lanthipeptides: LL065_RS24800_lanthipeptide
Lanthipeptides: LL065_RS24800_lanthipeptide
9
T L A C L G A S Y A L G D K G Q V C T A T V E C I N N C
36
T+ C L A S Y A L G++G++C T +V E C N N C
10
T V G C L-A S Y A L G N Q G K I C T W S V E C Q N N C
36
47.4%
NZ_JAGKQT010000007.1 and 3 others:
NZ_JAGKQT010000007.1 Lanthipeptides: J2M30_RS09860_lanthipeptide NZ_LVYL01000010.1 Lanthipeptides: A3863_RS05855_lanthipeptide NZ_LVYL01000010.1 Lanthipeptides: A3863_RS05855_lanthipeptide
Lanthipeptides: J2M30_RS09860_lanthipeptide
2
S W G T V L T T L A C L G A S Y A L G D K G Q V C T A T V E C I N N C R
37
+W T+ T+ C+ S+ +G+ G+V C T T V E C+N N C R
2
T W N T I S T S-T C I A V S H F V G N D G K V C T Y T V E C V N N C R
36

#### MIBiG 4.0 matches for BN6628_RS02285

31.6%
BGC0002110.3 (QKV49893.1):
Lanthipeptide: birimositide
16
S Y A L G D K G Q V C T A T V E C I N N C R
37
S A L G+ G C T T E C N C
9
S N A L G N N G G W C T L T K E C Q P N C N
30
28.9%
BGC0000517.4 (BAB04173.1):
Lanthipeptide: haloduracin β or haloduracin α
19
L G D K G Q V C T A T V E C I N N C
36
L G+K G C T T V E C+ +C
10
L G N K G A Y C T L T V E C M P S C
27
15.4%
BGC0001229.4 (SBI_06990):
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
26
C T A T V E C I N N C
36
C T + E C N C
28
C T L S K E C Q P N C
38
BN6628_RS02295
Leader:
MMRAELNQISGM
Core:
I E E N E L E L L A G N E D V K G G W T P V A T V V I S V I G L T M N A T P C P T S A C T K S C
Core with dehydrations:
I E E N E L E L L A G N E D V K G G W Dhb P V A Dhb V V I Dha V I G L Dhb M N A Dhb P Cys P Dhb Dha A Cys Dhb K Dha Cys

#### antiSMASH-DB 4.0 matches for BN6628_RS02295

100.0%
NZ_LT575476.1 and 1 other:
NZ_LT575476.1 Lanthipeptides: BN6628_RS02295_lanthipeptide
Lanthipeptides: BN6628_RS02295_lanthipeptide
1
I E E N E L E L L A G N E D V K G G W T P V A T V V I S V I G L T M N A T P C P T S A C T K S C
48
I E E N E L E L L A G N E D V K G G W T P V A T V V I S V I G L T M N A T P C P T S A C T K S C
1
I E E N E L E L L A G N E D V K G G W T P V A T V V I S V I G L T M N A T P C P T S A C T K S C
48
85.4%
NZ_JAQFWW010000002.1 and 1 other:
NZ_JAQFWW010000002.1 Lanthipeptides: PDT38_RS11320_lanthipeptide
Lanthipeptides: PDT38_RS11320_lanthipeptide
1
I E E N E L E L L A G N E D V K G G W T P V A T V V I S V I G L T M N A T P C P T S A C T K S C
48
I E E+E L E L A G N E D V G G W T P V A T V+I + G L T M N A T P C P T S A C T K S C
1
I E E S E L E A L A G N E D V S G G W T P V A T V I I G I T G L T M N A T P C P T S A C T K S C
48
39.6%
NZ_AKXV01000031.1 and 1 other:
NZ_AKXV01000031.1 Lanthipeptides: Y19_RS44045_lanthipeptide
Lanthipeptides: Y19_RS44045_lanthipeptide
4
N E L E L L-A G N E D V K G G W T P V A T V V I S V I G L T M N A T P C P T S A C T K S C
48
+E E L+ G D V G G T +V +V L ++A+ C P T+ C T C
2
D E F E L V E M G E A D V Y G G T T W S C A I V T A V A T L-V S A S A C P T T K C T S Q C
46
with 90 more sequence matches
Only the first 10 are displayed here.
39.6%
NZ_BNBV01000031.1 and 3 others:
NZ_BNBV01000031.1 Lanthipeptides: IE286_RS22985_lanthipeptide NZ_BNBV01000031.1 Lanthipeptides: IE286_RS22990_lanthipeptide NZ_BNBV01000031.1 Lanthipeptides: IE286_RS22985_lanthipeptide
Lanthipeptides: IE286_RS22990_lanthipeptide
4
N E L E L L A G N E-D V K G G W T P V A T V V I S V I G L T M N A T P C P T S A C T K S C
48
+E E L+ +E D V G G T P V+ V + +A C P T+ C T C
2
D E A E L I E L S E A D V T G G T T P V S I A V T----V A A S A A F C P T T K C T N D C
43
39.6%
NZ_CP016795.1 and 7 others:
NZ_CP016795.1 Lanthipeptides: BC342_RS37680_lanthipeptide NZ_CP036534.1 Lanthipeptides: EZV63_RS18955_lanthipeptide NZ_CP036534.1 Lanthipeptides: EZV63_RS18955_lanthipeptide NZ_CP043317.1 Lanthipeptides: FYC74_RS17685_lanthipeptide NZ_CP043317.1 Lanthipeptides: FYC74_RS17685_lanthipeptide NZ_CP094676.1 Lanthipeptides: L6J92_RS01490_lanthipeptide NZ_CP094676.1 Lanthipeptides: L6J92_RS01490_lanthipeptide
Lanthipeptides: BC342_RS37680_lanthipeptide
4
N E L E L L A G N E-D V K G G W T P V A T V V I S V I G L T M N A T P C P T S A C T K S C
48
+E E L+ +E D V G G T P V+ V + C P T+ C T K C
2
D E A E L I E L S E A D V T G G T T P V S V A V S V A A S V A F----C P T T K C T K E C
43
39.6%
NZ_KL997439.1 and 1 other:
NZ_KL997439.1 Lanthipeptides: IQ62_RS33140_lanthipeptide
Lanthipeptides: IQ62_RS33140_lanthipeptide
4
N E L E L L A G N E-D V K G G W T P--V A T V V I S V I G L T M N A T P C P T S A C T K S C
48
+E E L+ +E D G G P +A T V + ++A C P T+ C T S C
2
D E A E L I E L S E A D T H G G T G P W C I A T V T L------V S A V A C P T T K C T S S C
43
37.5%
NZ_BJTV01000004.1 and 1 other:
NZ_BJTV01000004.1 Lanthipeptides: TNCT1_RS35805_lanthipeptide
Lanthipeptides: TNCT1_RS35805_lanthipeptide
4
N E L E L L A G N E-D V K G G W T P V A T V V I S V I G L T M N A T P C P T S A C T K S C
48
+E E L+ +E D V G G T P V+ V + C P T C T +C
2
D E A E L I E L S E A D V T G G T T P V S I A V T V A A S V A F----C P T I K C T S A C
43
37.5%
NZ_BNBJ01000003.1 and 9 others:
NZ_BNBJ01000003.1 Lanthipeptides: IE304_RS05295_lanthipeptide NZ_CP079114.1 Lanthipeptides: KV381_RS19415_lanthipeptide NZ_CP079114.1 Lanthipeptides: KV381_RS19415_lanthipeptide NZ_JALDPQ010000054.1 Lanthipeptides: MQC87_RS11030_lanthipeptide NZ_JALDPQ010000054.1 Lanthipeptides: MQC87_RS11030_lanthipeptide NZ_JAMFLF010000021.1 Lanthipeptides: M1212_RS32890_lanthipeptide NZ_JAMFLF010000021.1 Lanthipeptides: M1212_RS32890_lanthipeptide NZ_JNZV01000231.1 Lanthipeptides: BG84_RS0100135_lanthipeptide NZ_JNZV01000231.1 Lanthipeptides: BG84_RS0100135_lanthipeptide
Lanthipeptides: IE304_RS05295_lanthipeptide
13
E D V K G G W T P V---A T V V I S V I G L T M N A T P--C P T S A C T K S C
48
E + G+T P A T V +V I A C P T S C T K C
2
E S L A A G F T P T I I P A T A V T T V I V G A S A A M Q G G C P T S G C T K R C
42
37.5%
NZ_BNCA01000011.1 and 1 other:
NZ_BNCA01000011.1 Lanthipeptides: IE314_RS15870_lanthipeptide
Lanthipeptides: IE314_RS15870_lanthipeptide
4
N E L E L L A G N E D V-K G G W T P V A T V V I S V I G L T M N A T P C P T S A C T K S C
48
+E L E L+ E D V G G T + S V ++ C P T+ C T C
2
D E L E L I E L G E D V A H G G T T S P V C I A T S V---A V S T A F C P T T K C T S K C
44
37.5%
NZ_JAASAG010000001.1 and 1 other:
NZ_JAASAG010000001.1 Lanthipeptides: HCC61_RS01465_lanthipeptide
Lanthipeptides: HCC61_RS01465_lanthipeptide
1
I E E N E L E L L A G N E D V K G G W T P--V A T V V I S V I G L T M N A T P C P T S A C T K S C
48
+E+E L L+ + D G G P V A T V ++ + C P T+ C T C
1
Y D E D E L V E L S-D A D T Y G G T G P W C V A T V T L A T A A I------C P T T K C T S Q C
43
37.5%
NZ_JAJAGO010000028.1 and 1 other:
NZ_JAJAGO010000028.1 Lanthipeptides: LHJ74_RS33595_lanthipeptide
Lanthipeptides: LHJ74_RS33595_lanthipeptide
1
I E E N E L E L L A G N E D V K G-------G W T P V A T V V I S V I G L T M N A T P C P T S A C T K S C
48
+E E L L A +E G W T + I S+ C P T S A C+ C
1
Y D E A E L I E L A D S E A F G G T S P A T T S S W T C I T A A T I S I---------C P T S A C S S K C
46
35.4%
NZ_BMRY01000003.1 and 9 others:
NZ_BMRY01000003.1 Lanthipeptides: IE140_RS12360_lanthipeptide NZ_CP084357.1 Lanthipeptides: LEL86_RS34975_lanthipeptide NZ_CP084357.1 Lanthipeptides: LEL86_RS34975_lanthipeptide NZ_JNLT01000014.1 Lanthipeptides: CD02_RS0123035_lanthipeptide NZ_JNLT01000014.1 Lanthipeptides: CD02_RS0123035_lanthipeptide NZ_KZ819178.1 Lanthipeptides: DBP20_RS18445_lanthipeptide NZ_KZ819178.1 Lanthipeptides: DBP20_RS18445_lanthipeptide NZ_NNBN01000001.1 Lanthipeptides: CG717_RS03745_lanthipeptide NZ_NNBN01000001.1 Lanthipeptides: CG717_RS03745_lanthipeptide
Lanthipeptides: IE140_RS12360_lanthipeptide
13
E D V K G G W T P V---A T V V I S V I G L T M N A T P--C P T S A C T K S C
48
+ + G+T P A T V +V I A C P T S C T K C
2
D S L A A G F T P T I I P A T A V T T V I V G A S A A M Q G G C P T S G C T K R C
42
35.4%
NZ_CP033054.1 and 11 others:
NZ_CP033054.1 Lanthipeptides: D9777_RS18840_lanthipeptide NZ_CP047268.1 Lanthipeptides: GKS41_RS18605_lanthipeptide NZ_CP047268.1 Lanthipeptides: GKS41_RS18605_lanthipeptide NZ_CP072563.1 Lanthipeptides: J6600_RS15935_lanthipeptide NZ_CP072563.1 Lanthipeptides: J6600_RS15935_lanthipeptide NZ_CP116014.1 Lanthipeptides: PF996_RS17885_lanthipeptide NZ_CP116014.1 Lanthipeptides: PF996_RS17885_lanthipeptide NZ_JAANHO010000006.1 Lanthipeptides: G9F75_RS12560_lanthipeptide NZ_JAANHO010000006.1 Lanthipeptides: G9F75_RS12560_lanthipeptide NZ_JAIONG010000001.1 Lanthipeptides: K8B35_RS01365_lanthipeptide NZ_JAIONG010000001.1 Lanthipeptides: K8B35_RS01365_lanthipeptide
Lanthipeptides: D9777_RS18840_lanthipeptide
20
T P V A T V V I S V I G L T-------M N A T P C P T S A C T K S C
48
T P V+ + I G L T ++A C P T S A C T K C
2
T P A T V V L T A T I G L T G T T F T V T L S A A S C P T S A C T K Q C
37

#### MIBiG 4.0 matches for BN6628_RS02295

14.6%
BGC0001229.4 (SBI_06989):
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
30
I G L T M N A T P C P T S A C T K S C
48
+ + ++A C P T+ C T C
19
V A V G V S A A F C P T T K C T S R C
37
12.5%
BGC0002110.3 (QKV49894.1):
Lanthipeptide: birimositide
39
C P T S A C T K S C
48
C P T+ C T C
17
C P T T K C T S K C
26
allorf_0444250_0444393
Leader:
MSILVIYFFLNEIRYG
Core:
R R R E L F S L K C K E F Y E K E R T K E G I R L L E E C N F
Core with dehydrations:
R R R E L F Dha L K Cys K E F Y E K E R Dhb K E G I R L L E E Cys N F

#### antiSMASH-DB 4.0 matches for allorf_0444250_0444393

100.0%
NZ_LT575476.1 and 1 other:
NZ_LT575476.1 Lanthipeptides: allorf_0444250_0444393_lanthipeptide
Lanthipeptides: allorf_0444250_0444393_lanthipeptide
1
R R R E L F S L K C K E F Y E K E R T K E G I R L L E E C N F
31
R R R E L F S L K C K E F Y E K E R T K E G I R L L E E C N F
1
R R R E L F S L K C K E F Y E K E R T K E G I R L L E E C N F
31
19.4%
NZ_CP061033.1:
Lanthipeptides: allorf_2073279_2073341_lanthipeptide
18
R T K E G I R L L E E C N
30
R T++G I R+ C+
1
R T R Q G I R I R R F C H
13
18.2%
NZ_CP077072.1:
Lanthipeptides: allorf_2268889_2269032_lanthipeptide
1
R R R E L F S L K C K E F Y E
15
R R R L L C ++
4
R R R S L V R L A C H R I H Q
18
with 1 more sequence matches
14.0%
NZ_CP095742.1:
Lanthipeptides: allorf_0677509_0677667_lanthipeptide
15
E K E R T K E G I R L L E E C
29
K+R G+R L C
1
A K D R V M S G V R L K R H C
15

#### MIBiG 4.0 matches for allorf_0444250_0444393

9.7%
BGC0000517.4 (BAB04173.1):
Lanthipeptide: haloduracin β or haloduracin α
6
F S L K C K E F Y E K E R T K E G I R L L E E C N
30
+++ C+ + + + C N
4
Y N I S C R L G N K G A Y C T L T V E C M P S C N
28

#### Lanthipeptide(s) for BN6628_RS02300

BN6628_RS02285
Leader:
MKMAVLKNPVLRNKIGYEGENPSGNVLEEIKDHDVVGA
Core:
I S W G T V L T T L A C L G A S Y A L G D K G Q V C T A T V E C I N N C R K
Core with dehydrations:
I Dha W G Dhb V L Dhb Dhb L A Cys L G A Dha Y A L G D K G Q V Cys Dhb A Dhb V E Cys I N N Cys R K

#### antiSMASH-DB 4.0 matches for BN6628_RS02285

100.0%
NZ_LT575476.1 and 1 other:
NZ_LT575476.1 Lanthipeptides: BN6628_RS02285_lanthipeptide
Lanthipeptides: BN6628_RS02285_lanthipeptide
1
I S W G T V L T T L A C L G A S Y A L G D K G Q V C T A T V E C I N N C R K
38
I S W G T V L T T L A C L G A S Y A L G D K G Q V C T A T V E C I N N C R K
1
I S W G T V L T T L A C L G A S Y A L G D K G Q V C T A T V E C I N N C R K
38
78.9%
NZ_JAQFWW010000002.1 and 1 other:
NZ_JAQFWW010000002.1 Lanthipeptides: PDT38_RS11330_lanthipeptide
Lanthipeptides: PDT38_RS11330_lanthipeptide
1
I S W G T V L T T L A C L G A S Y A L G D K G Q V C T A T V E C I N N C R K
38
I S W G T+L T T L+C L A S +G D K G Q V C T T V E C N N C R K
1
I S W G T L L T T L S C L A A S I M I G D K G Q V C T G T V E C Q N N C R K
38
57.9%
NZ_CP116355.1 and 1 other:
NZ_CP116355.1 Lanthipeptides: KPP03845_RS17815_lanthipeptide
Lanthipeptides: KPP03845_RS17815_lanthipeptide
3
W G T V L T T L A C L G A S Y A L G D K G Q V C T A T V E C I N N C R
37
W G T V+++L+C G A S Y L G+ G C T A T E C N N C+
4
W G T V M S S L S C Y G A S Y V L G N N G N F C T A T A E C Q N N C K
38
with 102 more sequence matches
Only the first 10 are displayed here.
55.3%
NZ_BMRY01000003.1 and 24 others:
NZ_BMRY01000003.1 Lanthipeptides: IE140_RS12370_lanthipeptide NZ_BMSZ01000006.1 Lanthipeptides: IE135_RS12780_lanthipeptide NZ_BMSZ01000006.1 Lanthipeptides: IE135_RS12780_lanthipeptide NZ_BNBJ01000003.1 Lanthipeptides: IE304_RS05285_lanthipeptide NZ_BNBJ01000003.1 Lanthipeptides: IE304_RS05285_lanthipeptide NZ_CP021707.1 Lanthipeptides: CCZ36_RS18205_lanthipeptide NZ_CP079114.1 Lanthipeptides: KV381_RS19425_lanthipeptide NZ_CP079114.1 Lanthipeptides: KV381_RS19425_lanthipeptide NZ_CP084357.1 Lanthipeptides: LEL86_RS34965_lanthipeptide NZ_CP084357.1 Lanthipeptides: LEL86_RS34965_lanthipeptide NZ_JALDPQ010000054.1 Lanthipeptides: MQC87_RS11020_lanthipeptide NZ_JALDPQ010000054.1 Lanthipeptides: MQC87_RS11020_lanthipeptide NZ_JAMFLF010000021.1 Lanthipeptides: M1212_RS32880_lanthipeptide NZ_JAMFLF010000021.1 Lanthipeptides: M1212_RS32880_lanthipeptide NZ_JNLT01000014.1 Lanthipeptides: CD02_RS38630_lanthipeptide NZ_JNLT01000014.1 Lanthipeptides: CD02_RS38630_lanthipeptide NZ_JNZV01000231.1 Lanthipeptides: BG84_RS0100145_lanthipeptide NZ_JNZV01000231.1 Lanthipeptides: BG84_RS0100145_lanthipeptide NZ_KZ819178.1 Lanthipeptides: DBP20_RS18455_lanthipeptide NZ_KZ819178.1 Lanthipeptides: DBP20_RS18455_lanthipeptide NZ_LZRD01000017.1 Lanthipeptides: A3Q37_RS19720_lanthipeptide NZ_LZRD01000017.1 Lanthipeptides: A3Q37_RS19720_lanthipeptide NZ_NNBN01000001.1 Lanthipeptides: CG717_RS03735_lanthipeptide NZ_NNBN01000001.1 Lanthipeptides: CG717_RS03735_lanthipeptide
Lanthipeptides: IE140_RS12370_lanthipeptide
3
W G T V L T T L A C L G A S Y A L G D K G Q V C T A T V E C I N N C R
37
W G T++++L+C G A S Y L G+ G C T A T E C N N C+
4
W G T I V S S L S C Y G A S Y V L G N N G N F C T A T A E C Q N N C K
38
55.3%
NZ_QKTG01000020.1 and 1 other:
NZ_QKTG01000020.1 Lanthipeptides: DEI99_RS16920_lanthipeptide
Lanthipeptides: DEI99_RS16920_lanthipeptide
4
G T V L T T L A C L G A S Y A L G D K G Q V C T A T V E C I N N C R
37
G T +T T L+C G S+A L G+ G C T A T V E C +N C+
4
G T T V T T L S C Y G V S W A L G N D G N F C T A T V E C Q S N C K
37
55.3%
NZ_WHOM01000078.1 and 1 other:
NZ_WHOM01000078.1 Lanthipeptides: GCN81_RS29300_lanthipeptide
Lanthipeptides: GCN81_RS29300_lanthipeptide
3
W G T V L T T L A C L G A S Y A L G D K G Q V C T A T V E C I N N C R
37
W G T L++L+C G A S Y L G+ G C T A T E C +N C+
4
W G T T L S S L S C Y G A S Y V L G N N G N F C T A T A E C Q S N C Q
38
53.8%
NZ_JALGRP010000007.1 and 1 other:
NZ_JALGRP010000007.1 Lanthipeptides: MT347_RS12955_lanthipeptide
Lanthipeptides: MT347_RS12955_lanthipeptide
3
W G T V L T T L A C L G A S Y A L G D K G Q V C T A T V E C I N N C R
37
W T +T+L C G S+ G+ G Q V C T A T V E C N N C
5
W T T T I T S L T C Y G V S W V A G N N G Q V C T A T V E C Q N N C N
39
50.0%
NZ_JALIRS010000003.1 and 3 others:
NZ_JALIRS010000003.1 Lanthipeptides: MOK21_RS07255_lanthipeptide NZ_JALNLQ010000002.1 Lanthipeptides: MWJ95_RS06810_lanthipeptide NZ_JALNLQ010000002.1 Lanthipeptides: MWJ95_RS06810_lanthipeptide
Lanthipeptides: MOK21_RS07255_lanthipeptide
5
T V L T T L A C L G A S Y A L G D K G Q V C T A T V E C I N N C
36
T+L T+L A C A S Y L G+ G V C T T V E C C
8
T I L T S L A C A A A S Y I L G N P G H V C T L T V E C Q K K C
39
47.4%
NC_017299.1 and 1 other:
NC_017299.1 Lanthipeptides: H04402_RS03105_lanthipeptide
Lanthipeptides: H04402_RS03105_lanthipeptide
1
I S W G T V L T T L A C L G A S Y A L G D K G Q V C T A T V E C I N N C
36
S G T+ T L S +G+ G+V C T T V E C N N C
2
F S E G T I S I T L-----S V Y M G N D G K V C T W T V E C Q N N C
32
47.4%
NZ_BQXZ01000001.1 and 1 other:
NZ_BQXZ01000001.1 Lanthipeptides: OCU69_RS05000_lanthipeptide
Lanthipeptides: OCU69_RS05000_lanthipeptide
1
I S W G T V L T T L A C L G A S Y A L G D K G Q V C T A T V E C I N N C R K
38
S G T+ T L S +G+K G V C T T+E C +N C K
2
F S G G T I S I T L-----S V Y M G N K G S V C T W T I E C Q S N C S K
34
47.4%
NZ_CM000756.1 and 7 others:
NZ_CM000756.1 Lanthipeptides: BTHUR0011_RS34475_lanthipeptide NZ_CP031749.1 Lanthipeptides: DPQ26_RS30450_lanthipeptide NZ_CP031749.1 Lanthipeptides: DPQ26_RS30450_lanthipeptide NZ_CP036071.1 Lanthipeptides: EXW41_RS29770_lanthipeptide NZ_CP036071.1 Lanthipeptides: EXW41_RS29770_lanthipeptide NZ_WBPC01000036.1 Lanthipeptides: F8159_RS30260_lanthipeptide NZ_WBPC01000036.1 Lanthipeptides: F8159_RS30260_lanthipeptide
Lanthipeptides: BTHUR0011_RS34475_lanthipeptide
2
S W G T V L T T L A C L G A S Y A L G D K G Q V C T A T V E C I N N C R
37
+W T T+ + + S G+K G+V C T T V E C+N N C R
3
T W N T T A T S T S I I-I S E T F G N K G K V C T Y T V E C V N N C R
37
47.4%
NZ_CP086141.1 and 1 other:
NZ_CP086141.1 Lanthipeptides: LL065_RS24800_lanthipeptide
Lanthipeptides: LL065_RS24800_lanthipeptide
9
T L A C L G A S Y A L G D K G Q V C T A T V E C I N N C
36
T+ C L A S Y A L G++G++C T +V E C N N C
10
T V G C L-A S Y A L G N Q G K I C T W S V E C Q N N C
36
47.4%
NZ_JAGKQT010000007.1 and 3 others:
NZ_JAGKQT010000007.1 Lanthipeptides: J2M30_RS09860_lanthipeptide NZ_LVYL01000010.1 Lanthipeptides: A3863_RS05855_lanthipeptide NZ_LVYL01000010.1 Lanthipeptides: A3863_RS05855_lanthipeptide
Lanthipeptides: J2M30_RS09860_lanthipeptide
2
S W G T V L T T L A C L G A S Y A L G D K G Q V C T A T V E C I N N C R
37
+W T+ T+ C+ S+ +G+ G+V C T T V E C+N N C R
2
T W N T I S T S-T C I A V S H F V G N D G K V C T Y T V E C V N N C R
36

#### MIBiG 4.0 matches for BN6628_RS02285

31.6%
BGC0002110.3 (QKV49893.1):
Lanthipeptide: birimositide
16
S Y A L G D K G Q V C T A T V E C I N N C R
37
S A L G+ G C T T E C N C
9
S N A L G N N G G W C T L T K E C Q P N C N
30
28.9%
BGC0000517.4 (BAB04173.1):
Lanthipeptide: haloduracin β or haloduracin α
19
L G D K G Q V C T A T V E C I N N C
36
L G+K G C T T V E C+ +C
10
L G N K G A Y C T L T V E C M P S C
27
15.4%
BGC0001229.4 (SBI_06990):
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
26
C T A T V E C I N N C
36
C T + E C N C
28
C T L S K E C Q P N C
38
BN6628_RS02295
Leader:
MMRAELNQISGM
Core:
I E E N E L E L L A G N E D V K G G W T P V A T V V I S V I G L T M N A T P C P T S A C T K S C
Core with dehydrations:
I E E N E L E L L A G N E D V K G G W Dhb P V A Dhb V V I Dha V I G L Dhb M N A Dhb P Cys P Dhb Dha A Cys Dhb K Dha Cys

#### antiSMASH-DB 4.0 matches for BN6628_RS02295

100.0%
NZ_LT575476.1 and 1 other:
NZ_LT575476.1 Lanthipeptides: BN6628_RS02295_lanthipeptide
Lanthipeptides: BN6628_RS02295_lanthipeptide
1
I E E N E L E L L A G N E D V K G G W T P V A T V V I S V I G L T M N A T P C P T S A C T K S C
48
I E E N E L E L L A G N E D V K G G W T P V A T V V I S V I G L T M N A T P C P T S A C T K S C
1
I E E N E L E L L A G N E D V K G G W T P V A T V V I S V I G L T M N A T P C P T S A C T K S C
48
85.4%
NZ_JAQFWW010000002.1 and 1 other:
NZ_JAQFWW010000002.1 Lanthipeptides: PDT38_RS11320_lanthipeptide
Lanthipeptides: PDT38_RS11320_lanthipeptide
1
I E E N E L E L L A G N E D V K G G W T P V A T V V I S V I G L T M N A T P C P T S A C T K S C
48
I E E+E L E L A G N E D V G G W T P V A T V+I + G L T M N A T P C P T S A C T K S C
1
I E E S E L E A L A G N E D V S G G W T P V A T V I I G I T G L T M N A T P C P T S A C T K S C
48
39.6%
NZ_AKXV01000031.1 and 1 other:
NZ_AKXV01000031.1 Lanthipeptides: Y19_RS44045_lanthipeptide
Lanthipeptides: Y19_RS44045_lanthipeptide
4
N E L E L L-A G N E D V K G G W T P V A T V V I S V I G L T M N A T P C P T S A C T K S C
48
+E E L+ G D V G G T +V +V L ++A+ C P T+ C T C
2
D E F E L V E M G E A D V Y G G T T W S C A I V T A V A T L-V S A S A C P T T K C T S Q C
46
with 90 more sequence matches
Only the first 10 are displayed here.
39.6%
NZ_BNBV01000031.1 and 3 others:
NZ_BNBV01000031.1 Lanthipeptides: IE286_RS22985_lanthipeptide NZ_BNBV01000031.1 Lanthipeptides: IE286_RS22990_lanthipeptide NZ_BNBV01000031.1 Lanthipeptides: IE286_RS22985_lanthipeptide
Lanthipeptides: IE286_RS22990_lanthipeptide
4
N E L E L L A G N E-D V K G G W T P V A T V V I S V I G L T M N A T P C P T S A C T K S C
48
+E E L+ +E D V G G T P V+ V + +A C P T+ C T C
2
D E A E L I E L S E A D V T G G T T P V S I A V T----V A A S A A F C P T T K C T N D C
43
39.6%
NZ_CP016795.1 and 7 others:
NZ_CP016795.1 Lanthipeptides: BC342_RS37680_lanthipeptide NZ_CP036534.1 Lanthipeptides: EZV63_RS18955_lanthipeptide NZ_CP036534.1 Lanthipeptides: EZV63_RS18955_lanthipeptide NZ_CP043317.1 Lanthipeptides: FYC74_RS17685_lanthipeptide NZ_CP043317.1 Lanthipeptides: FYC74_RS17685_lanthipeptide NZ_CP094676.1 Lanthipeptides: L6J92_RS01490_lanthipeptide NZ_CP094676.1 Lanthipeptides: L6J92_RS01490_lanthipeptide
Lanthipeptides: BC342_RS37680_lanthipeptide
4
N E L E L L A G N E-D V K G G W T P V A T V V I S V I G L T M N A T P C P T S A C T K S C
48
+E E L+ +E D V G G T P V+ V + C P T+ C T K C
2
D E A E L I E L S E A D V T G G T T P V S V A V S V A A S V A F----C P T T K C T K E C
43
39.6%
NZ_KL997439.1 and 1 other:
NZ_KL997439.1 Lanthipeptides: IQ62_RS33140_lanthipeptide
Lanthipeptides: IQ62_RS33140_lanthipeptide
4
N E L E L L A G N E-D V K G G W T P--V A T V V I S V I G L T M N A T P C P T S A C T K S C
48
+E E L+ +E D G G P +A T V + ++A C P T+ C T S C
2
D E A E L I E L S E A D T H G G T G P W C I A T V T L------V S A V A C P T T K C T S S C
43
37.5%
NZ_BJTV01000004.1 and 1 other:
NZ_BJTV01000004.1 Lanthipeptides: TNCT1_RS35805_lanthipeptide
Lanthipeptides: TNCT1_RS35805_lanthipeptide
4
N E L E L L A G N E-D V K G G W T P V A T V V I S V I G L T M N A T P C P T S A C T K S C
48
+E E L+ +E D V G G T P V+ V + C P T C T +C
2
D E A E L I E L S E A D V T G G T T P V S I A V T V A A S V A F----C P T I K C T S A C
43
37.5%
NZ_BNBJ01000003.1 and 9 others:
NZ_BNBJ01000003.1 Lanthipeptides: IE304_RS05295_lanthipeptide NZ_CP079114.1 Lanthipeptides: KV381_RS19415_lanthipeptide NZ_CP079114.1 Lanthipeptides: KV381_RS19415_lanthipeptide NZ_JALDPQ010000054.1 Lanthipeptides: MQC87_RS11030_lanthipeptide NZ_JALDPQ010000054.1 Lanthipeptides: MQC87_RS11030_lanthipeptide NZ_JAMFLF010000021.1 Lanthipeptides: M1212_RS32890_lanthipeptide NZ_JAMFLF010000021.1 Lanthipeptides: M1212_RS32890_lanthipeptide NZ_JNZV01000231.1 Lanthipeptides: BG84_RS0100135_lanthipeptide NZ_JNZV01000231.1 Lanthipeptides: BG84_RS0100135_lanthipeptide
Lanthipeptides: IE304_RS05295_lanthipeptide
13
E D V K G G W T P V---A T V V I S V I G L T M N A T P--C P T S A C T K S C
48
E + G+T P A T V +V I A C P T S C T K C
2
E S L A A G F T P T I I P A T A V T T V I V G A S A A M Q G G C P T S G C T K R C
42
37.5%
NZ_BNCA01000011.1 and 1 other:
NZ_BNCA01000011.1 Lanthipeptides: IE314_RS15870_lanthipeptide
Lanthipeptides: IE314_RS15870_lanthipeptide
4
N E L E L L A G N E D V-K G G W T P V A T V V I S V I G L T M N A T P C P T S A C T K S C
48
+E L E L+ E D V G G T + S V ++ C P T+ C T C
2
D E L E L I E L G E D V A H G G T T S P V C I A T S V---A V S T A F C P T T K C T S K C
44
37.5%
NZ_JAASAG010000001.1 and 1 other:
NZ_JAASAG010000001.1 Lanthipeptides: HCC61_RS01465_lanthipeptide
Lanthipeptides: HCC61_RS01465_lanthipeptide
1
I E E N E L E L L A G N E D V K G G W T P--V A T V V I S V I G L T M N A T P C P T S A C T K S C
48
+E+E L L+ + D G G P V A T V ++ + C P T+ C T C
1
Y D E D E L V E L S-D A D T Y G G T G P W C V A T V T L A T A A I------C P T T K C T S Q C
43
37.5%
NZ_JAJAGO010000028.1 and 1 other:
NZ_JAJAGO010000028.1 Lanthipeptides: LHJ74_RS33595_lanthipeptide
Lanthipeptides: LHJ74_RS33595_lanthipeptide
1
I E E N E L E L L A G N E D V K G-------G W T P V A T V V I S V I G L T M N A T P C P T S A C T K S C
48
+E E L L A +E G W T + I S+ C P T S A C+ C
1
Y D E A E L I E L A D S E A F G G T S P A T T S S W T C I T A A T I S I---------C P T S A C S S K C
46
35.4%
NZ_BMRY01000003.1 and 9 others:
NZ_BMRY01000003.1 Lanthipeptides: IE140_RS12360_lanthipeptide NZ_CP084357.1 Lanthipeptides: LEL86_RS34975_lanthipeptide NZ_CP084357.1 Lanthipeptides: LEL86_RS34975_lanthipeptide NZ_JNLT01000014.1 Lanthipeptides: CD02_RS0123035_lanthipeptide NZ_JNLT01000014.1 Lanthipeptides: CD02_RS0123035_lanthipeptide NZ_KZ819178.1 Lanthipeptides: DBP20_RS18445_lanthipeptide NZ_KZ819178.1 Lanthipeptides: DBP20_RS18445_lanthipeptide NZ_NNBN01000001.1 Lanthipeptides: CG717_RS03745_lanthipeptide NZ_NNBN01000001.1 Lanthipeptides: CG717_RS03745_lanthipeptide
Lanthipeptides: IE140_RS12360_lanthipeptide
13
E D V K G G W T P V---A T V V I S V I G L T M N A T P--C P T S A C T K S C
48
+ + G+T P A T V +V I A C P T S C T K C
2
D S L A A G F T P T I I P A T A V T T V I V G A S A A M Q G G C P T S G C T K R C
42
35.4%
NZ_CP033054.1 and 11 others:
NZ_CP033054.1 Lanthipeptides: D9777_RS18840_lanthipeptide NZ_CP047268.1 Lanthipeptides: GKS41_RS18605_lanthipeptide NZ_CP047268.1 Lanthipeptides: GKS41_RS18605_lanthipeptide NZ_CP072563.1 Lanthipeptides: J6600_RS15935_lanthipeptide NZ_CP072563.1 Lanthipeptides: J6600_RS15935_lanthipeptide NZ_CP116014.1 Lanthipeptides: PF996_RS17885_lanthipeptide NZ_CP116014.1 Lanthipeptides: PF996_RS17885_lanthipeptide NZ_JAANHO010000006.1 Lanthipeptides: G9F75_RS12560_lanthipeptide NZ_JAANHO010000006.1 Lanthipeptides: G9F75_RS12560_lanthipeptide NZ_JAIONG010000001.1 Lanthipeptides: K8B35_RS01365_lanthipeptide NZ_JAIONG010000001.1 Lanthipeptides: K8B35_RS01365_lanthipeptide
Lanthipeptides: D9777_RS18840_lanthipeptide
20
T P V A T V V I S V I G L T-------M N A T P C P T S A C T K S C
48
T P V+ + I G L T ++A C P T S A C T K C
2
T P A T V V L T A T I G L T G T T F T V T L S A A S C P T S A C T K Q C
37

#### MIBiG 4.0 matches for BN6628_RS02295

14.6%
BGC0001229.4 (SBI_06989):
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
30
I G L T M N A T P C P T S A C T K S C
48
+ + ++A C P T+ C T C
19
V A V G V S A A F C P T T K C T S R C
37
12.5%
BGC0002110.3 (QKV49894.1):
Lanthipeptide: birimositide
39
C P T S A C T K S C
48
C P T+ C T C
17
C P T T K C T S K C
26
allorf_0444250_0444393
Leader:
MSILVIYFFLNEIRYG
Core:
R R R E L F S L K C K E F Y E K E R T K E G I R L L E E C N F
Core with dehydrations:
R R R E L F Dha L K Cys K E F Y E K E R Dhb K E G I R L L E E Cys N F

#### antiSMASH-DB 4.0 matches for allorf_0444250_0444393

100.0%
NZ_LT575476.1 and 1 other:
NZ_LT575476.1 Lanthipeptides: allorf_0444250_0444393_lanthipeptide
Lanthipeptides: allorf_0444250_0444393_lanthipeptide
1
R R R E L F S L K C K E F Y E K E R T K E G I R L L E E C N F
31
R R R E L F S L K C K E F Y E K E R T K E G I R L L E E C N F
1
R R R E L F S L K C K E F Y E K E R T K E G I R L L E E C N F
31
19.4%
NZ_CP061033.1:
Lanthipeptides: allorf_2073279_2073341_lanthipeptide
18
R T K E G I R L L E E C N
30
R T++G I R+ C+
1
R T R Q G I R I R R F C H
13
18.2%
NZ_CP077072.1:
Lanthipeptides: allorf_2268889_2269032_lanthipeptide
1
R R R E L F S L K C K E F Y E
15
R R R L L C ++
4
R R R S L V R L A C H R I H Q
18
with 1 more sequence matches
14.0%
NZ_CP095742.1:
Lanthipeptides: allorf_0677509_0677667_lanthipeptide
15
E K E R T K E G I R L L E E C
29
K+R G+R L C
1
A K D R V M S G V R L K R H C
15

#### MIBiG 4.0 matches for allorf_0444250_0444393

9.7%
BGC0000517.4 (BAB04173.1):
Lanthipeptide: haloduracin β or haloduracin α
6
F S L K C K E F Y E K E R T K E G I R L L E E C N
30
+++ C+ + + + C N
4
Y N I S C R L G N K G A Y C T L T V E C M P S C N
28

#### Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine
Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 17.48 out of 18.57
Confidence: strong
GnfM
Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 21.29 out of 27.55
Confidence: medium
ArcA
Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 18.97 out of 21.55
Confidence: medium
Additional weak hits (3):
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 20.54 out of 29.38
Confidence: weak
NrtR
Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 22.05 out of 35.63
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 20.31 out of 28.14
Confidence: weak
Lanthipeptides
TFBS Finder
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of lanthionine bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.

BN6628_RS02285 - Class II
  Cleavage pHMM score: 0.10
  RODEO score: 0
  Monoisotopic mass: 3832.9 Da
  Molecular weight: 3835.4 Da
  Number of bridges: 4
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3853.4 Da N = 1
    3871.5 Da N = 2
    3889.5 Da N = 3
BN6628_RS02295 - Class II
  Cleavage pHMM score: 1.10
  RODEO score: 0
  Monoisotopic mass: 4798.4 Da
  Molecular weight: 4801.5 Da
  Number of bridges: 3
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    4819.5 Da N = 1
    4837.5 Da N = 2
    4855.5 Da N = 3
    4873.5 Da N = 4
    4891.6 Da N = 5
    4909.6 Da N = 6
allorf_0444250_0444393 - Class II
  Cleavage pHMM score: -2.50
  RODEO score: 0
  Monoisotopic mass: 3913.0 Da
  Molecular weight: 3915.5 Da
  Number of bridges: 2
BN6628_RS02285 - Class II
  Cleavage pHMM score: 0.10
  RODEO score: 0
  Monoisotopic mass: 3832.9 Da
  Molecular weight: 3835.4 Da
  Number of bridges: 4
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3853.4 Da N = 1
    3871.5 Da N = 2
    3889.5 Da N = 3
BN6628_RS02295 - Class II
  Cleavage pHMM score: 1.10
  RODEO score: 0
  Monoisotopic mass: 4798.4 Da
  Molecular weight: 4801.5 Da
  Number of bridges: 3
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    4819.5 Da N = 1
    4837.5 Da N = 2
    4855.5 Da N = 3
    4873.5 Da N = 4
    4891.6 Da N = 5
    4909.6 Da N = 6
allorf_0444250_0444393 - Class II
  Cleavage pHMM score: -2.50
  RODEO score: 0
  Monoisotopic mass: 3913.0 Da
  Molecular weight: 3915.5 Da
  Number of bridges: 2

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
ArcA | Repressor of carbon oxidation
GnfM | Regulator of nitrogen-fixation genes
ToxT | Regulator of MSHA biosynthesis

NZ_LT575476.1 - Region 3 - proteusin
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,073,505 - 1,093,756 nt. (total: 20,252 nt) Show pHMM detection rules used
proteusin: (PoyD or TIGR03793)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Hydrolases: hydrolase
BN6628_RS04900: hydrolase

smcogs
  SMCOG1179: hydrolase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | proteusin | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002073.3 |  | 0.36 | NRPS | dehydroxynocardamine | Corynebacterium propinquum
BGC0000943.5 |  | 0.35 | other (other) | staphyloferrin B | Staphylococcus aureus subsp. aureus NCTC 8325
BGC0002690.2 |  | 0.35 | other (other) | FW0622 | Verrucosispora sp. FIM060022
BGC0001810.3 |  | 0.35 | PKS | trehangelin | Polymorphospora rubra
BGC0002285.2 |  | 0.35 | ribosomal | aborycin | Streptomyces sp. ZS0098
BGC0000947.5 |  | 0.34 | other (other) | vibrioferrin | Vibrio alginolyticus
BGC0002695.2 |  | 0.34 | NRPS | bacillibactin, bacillibactin E, bacillibactin F | Bacillus sp. WMMC1349
BGC0002682.2 |  | 0.34 | other (other) | aerobactin | Vibrio mimicus
BGC0000939.5 |  | 0.33 | other (other) | aerobactin | Grimontia hollisae
BGC0002495.2 |  | 0.33 | NRPS | photobactin | Photorhabdus luminescens

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002073.3 |  | 0.36 | NRPS | dehydroxynocardamine | Corynebacterium propinquum
BGC0000943.5 |  | 0.35 | other (other) | staphyloferrin B | Staphylococcus aureus subsp. aureus NCTC 8325
BGC0002690.2 |  | 0.35 | other (other) | FW0622 | Verrucosispora sp. FIM060022
BGC0001810.3 |  | 0.35 | PKS | trehangelin | Polymorphospora rubra
BGC0002285.2 |  | 0.35 | ribosomal | aborycin | Streptomyces sp. ZS0098
BGC0000947.5 |  | 0.34 | other (other) | vibrioferrin | Vibrio alginolyticus
BGC0002695.2 |  | 0.34 | NRPS | bacillibactin, bacillibactin E, bacillibactin F | Bacillus sp. WMMC1349
BGC0002682.2 |  | 0.34 | other (other) | aerobactin | Vibrio mimicus
BGC0000939.5 |  | 0.33 | other (other) | aerobactin | Grimontia hollisae
BGC0002495.2 |  | 0.33 | NRPS | photobactin | Photorhabdus luminescens

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57
Confidence: strong
Additional weak hits (1):
RutR
Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.84 out of 26.85
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
ToxT | Regulator of MSHA biosynthesis

NZ_LT575476.1 - Region 4 - terpene-precursor
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,154,709 - 2,175,584 nt. (total: 20,876 nt) Show pHMM detection rules used
terpene-precursor: (PT_FPPS_like and not PT_HPP)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Terpene
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Transferases: carboxylase
BN6628_RS09890: acetyl-CoA carboxylase biotin carboxylase

smcogs
  SMCOG1090: acetyl-CoA carboxylase biotin carboxylase

Ligases: synthase synthetase
BN6628_RS09930: Polyprenyl synthetase

smcogs
  SMCOG1182: Polyprenyl synthetase

BN6628_RS09935: 1-deoxy-D-xylulose-5-phosphate synthase

smcogs
  SMCOG1110: 1-deoxy-D-xylulose-5-phosphate synthase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene-precursor | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001361.3 |  | 0.49 | terpene | sodorifen | Serratia plymuthica 4Rx13
BGC0002283.2 |  | 0.49 | terpene | sodorifen | Serratia plymuthica
BGC0002397.2 |  | 0.47 | terpene | astallatene | Arabidopsis thaliana
BGC0002400.2 |  | 0.44 | terpene | boleracene | Brassica oleracea var. oleracea
BGC0002398.2 |  | 0.38 | terpene | (-)-ent-quiannulatene | Arabidopsis thaliana
BGC0002284.3 |  | 0.38 | other (other) | corynecin III, corynecin I, corynecin II | Rhodococcus sp. H-CA8f
BGC0000665.5 |  | 0.38 | other (other), terpene | xiamycin, indosespene, sespenine, dixiamycin A, dixiamycin B, sulfadixiamycin A, sulfadixiamycin B, sulfadixiamycin C | Streptomyces sp. HKI0576
BGC0001594.3 |  | 0.37 | other (other) | fischerindole L | Fischerella muscicola UTEX 1829
BGC0000666.5 |  | 0.36 | terpene | xiamycin A | Streptomyces sp. SCSIO 02999
BGC0001501.5 |  | 0.36 | other (other) | ambiguine P | Fischerella sp. TAU

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001361.3 |  | 0.49 | terpene | sodorifen | Serratia plymuthica 4Rx13
BGC0002283.2 |  | 0.49 | terpene | sodorifen | Serratia plymuthica
BGC0002397.2 |  | 0.47 | terpene | astallatene | Arabidopsis thaliana
BGC0002400.2 |  | 0.44 | terpene | boleracene | Brassica oleracea var. oleracea
BGC0002398.2 |  | 0.38 | terpene | (-)-ent-quiannulatene | Arabidopsis thaliana
BGC0002284.3 |  | 0.38 | other (other) | corynecin III, corynecin I, corynecin II | Rhodococcus sp. H-CA8f
BGC0000665.5 |  | 0.38 | other (other), terpene | xiamycin, indosespene, sespenine, dixiamycin A, dixiamycin B, sulfadixiamycin A, sulfadixiamycin B, sulfadixiamycin C | Streptomyces sp. HKI0576
BGC0001594.3 |  | 0.37 | other (other) | fischerindole L | Fischerella muscicola UTEX 1829
BGC0000666.5 |  | 0.36 | terpene | xiamycin A | Streptomyces sp. SCSIO 02999
BGC0001501.5 |  | 0.36 | other (other) | ambiguine P | Fischerella sp. TAU

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Detailed terpene predictions
Detailed information for terpene domains. Shows possible products of a terpene cluster and lists the subtype and expected reactions for each terpene-related domain.
Product predictions:

Class | Subclass | Product name | Chain length | Initial cyclisations | Functional groups
--- | --- | --- | --- | --- | ---
sesquiterpene precursor |  | FPP | C15 | acyclic | PP

Genes with terpene domains:
BN6628_RS09930: PT_FPPS_like
Domain 1 (26 - 291): Prenyltransferase; Farnesyl diphosphate synthase like
Subtype: Farnesyl diphosphate synthase, bacterial

Reactions:
  DMAPP, IPP → FPP

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
AbrC3
Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 18.16 out of 18.16
Confidence: strong
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.04 out of 18.57
Confidence: strong
VqsM
Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 18.50 out of 20.47
Confidence: medium
Additional weak hits (5):
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 23.02 out of 28.14
Confidence: weak
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 22.13 out of 31.73
Confidence: weak
ClgR
Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 21.44 out of 30.22
Confidence: weak
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 21.48 out of 29.25
Confidence: weak
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.13 out of 30.25
Confidence: weak
Terpene
TFBS Finder
Glossary
Glossary showing acronyms and their full names.

Acronym | Full name
--- | ---
DMAPP | Dimethylallyl diphosphate
FPP | Farnesyl diphosphate
IPP | Isopentenyl diphosphate
PP | Diphosphate

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
AbrC3 | Antibiotic production activator
ToxT | Regulator of MSHA biosynthesis
VqsM | Regulator of quorum-sensing signalling systems

NZ_LT575476.1 - Region 5 - T3PKS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,554,851 - 2,596,008 nt. (total: 41,158 nt) Show pHMM detection rules used
T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase oxidoreductase
BN6628_RS11910: oxidoreductase

smcogs
  SMCOG1161: oxidoreductase

BN6628_RS11950: alcohol dehydrogenase

smcogs
  SMCOG1040: alcohol dehydrogenase

BN6628_RS11980: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

BN6628_RS11985: aldo/keto reductase family oxidoreductase

smcogs
  SMCOG1039: aldo/keto reductase family oxidoreductase

Hydrolases: hydrolase
BN6628_RS11925: beta-lactamase

smcogs
  SMCOG1053: beta-lactamase

Ligases: synthase
BN6628_RS11900: chalcone and stilbene synthase domain protein

smcogs
  SMCOG1024: chalcone and stilbene synthase domain protein

Translocases: transporter
BN6628_RS11860: sugar-binding lipoprotein

smcogs
  SMCOG1143: sugar-binding lipoprotein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | T3PKS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002276.2 |  | 0.54 | NRPS | choline | Aspergillus nidulans FGSC A4
BGC0001962.3 |  | 0.50 | PKS | hierridin B, hierridin C | Cyanobium sp. LEGE 06113
BGC0002332.2 |  | 0.45 | PKS | 4-hydroxy-6-pentadecylpyran-2-one, 4-hydroxy-6-(2-oxoheptadecyl)pyran-2-one, Adipostatin A | Candidatus Entotheonella sp.
BGC0001077.4 |  | 0.44 | PKS | 6-anteisoheptadecyl-4-O-dihydrogeranyl-2-methoxyhydroquinone, 6-isoheptadecyl-4-O-dihydrogeranyl-2-methoxyhydroquinone, 6-isopalmityl-4-O-geranyl-2-methoxyhydroquinone, 6-palmityl-4-O-geranyl-2-methoxyhydroquinone, 6-anteisoheptadecyl-4-O-geranyl-2-methoxyhydroquinone, 6-isoheptadecyl-4-O-geranyl-2-methoxyhydroquinone, 6-isopalmityl-4-O-dihydrofarnesyl-2-methoxyhydroquinone, 6-palmityl-4-O-dihydrofarnesyl-2-methoxyhydroquinone, 6-anteisoheptadecyl-4-O-dihydrofarnesyl-2-methoxyhydroquinone, 6-isoheptadecyl-4-O-dihydrofarnesyl-2-methoxyhydroquinone | Actinoplanes missouriensis 431
BGC0000883.5 |  | 0.42 | other (other) | arginomycin | Streptomyces arginensis
BGC0002707.2 |  | 0.41 | terpene | (+)-δ-cadinol | Coniophora puteana RWD-64-598 SS2
BGC0000550.3 |  | 0.41 | ribosomal | salivaricin G32 | Streptococcus salivarius
BGC0000888.5 |  | 0.41 | other (other) | bacilysin | Bacillus sp. CS93
BGC0000243.4 |  | 0.41 | PKS | nonactin, monactin, dinactin, trinactin, tetranactin | Streptomyces griseus subsp. griseus
BGC0001184.4 |  | 0.40 | other (other) | bacilysin | Bacillus velezensis FZB42

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002276.2 |  | 0.54 | NRPS | choline | Aspergillus nidulans FGSC A4
BGC0001962.3 |  | 0.50 | PKS | hierridin B, hierridin C | Cyanobium sp. LEGE 06113
BGC0002332.2 |  | 0.45 | PKS | 4-hydroxy-6-pentadecylpyran-2-one, 4-hydroxy-6-(2-oxoheptadecyl)pyran-2-one, Adipostatin A | Candidatus Entotheonella sp.
BGC0001077.4 |  | 0.44 | PKS | 6-anteisoheptadecyl-4-O-dihydrogeranyl-2-methoxyhydroquinone, 6-isoheptadecyl-4-O-dihydrogeranyl-2-methoxyhydroquinone, 6-isopalmityl-4-O-geranyl-2-methoxyhydroquinone, 6-palmityl-4-O-geranyl-2-methoxyhydroquinone, 6-anteisoheptadecyl-4-O-geranyl-2-methoxyhydroquinone, 6-isoheptadecyl-4-O-geranyl-2-methoxyhydroquinone, 6-isopalmityl-4-O-dihydrofarnesyl-2-methoxyhydroquinone, 6-palmityl-4-O-dihydrofarnesyl-2-methoxyhydroquinone, 6-anteisoheptadecyl-4-O-dihydrofarnesyl-2-methoxyhydroquinone, 6-isoheptadecyl-4-O-dihydrofarnesyl-2-methoxyhydroquinone | Actinoplanes missouriensis 431
BGC0000883.5 |  | 0.42 | other (other) | arginomycin | Streptomyces arginensis
BGC0002707.2 |  | 0.41 | terpene | (+)-δ-cadinol | Coniophora puteana RWD-64-598 SS2
BGC0000550.3 |  | 0.41 | ribosomal | salivaricin G32 | Streptococcus salivarius
BGC0000888.5 |  | 0.41 | other (other) | bacilysin | Bacillus sp. CS93
BGC0000243.4 |  | 0.41 | PKS | nonactin, monactin, dinactin, trinactin, tetranactin | Streptomyces griseus subsp. griseus
BGC0001184.4 |  | 0.40 | other (other) | bacilysin | Bacillus velezensis FZB42

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.43 out of 27.78
Confidence: medium
Additional weak hits (10):
HgtR
Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 24.82 out of 36.54
Confidence: weak
PsrA
Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 19.91 out of 25.88
Confidence: weak
ANR
Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 20.06 out of 26.33
Confidence: weak
HgtR
Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 23.15 out of 36.54
Confidence: weak
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 24.36 out of 32.74
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.29 out of 26.06
Confidence: weak
PsrA
Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 20.33 out of 25.88
Confidence: weak
LexA variant 1
Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 21.27 out of 29.65
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 20.77 out of 28.14
Confidence: weak
NuR
Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 23.00 out of 30.98
Confidence: weak
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria

NZ_LT575476.1 - Region 6 - NRPS,T1PKS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,828,009 - 2,914,400 nt. (total: 86,392 nt) Show pHMM detection rules used
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)
T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS modules
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase electron transfer oxidoreductase
BN6628_RS13035: aldo/keto reductase family oxidoreductase

smcogs
  SMCOG1039: aldo/keto reductase family oxidoreductase

BN6628_RS13135: acyl-CoA dehydrogenase

smcogs
  SMCOG1006: acyl-CoA dehydrogenase

BN6628_RS13145: 3-hydroxybutyryl-CoA dehydrogenase

smcogs
  SMCOG1095: 3-hydroxybutyryl-CoA dehydrogenase

BN6628_RS13210: pyridine nucleotide-disulfide oxidoreductase

smcogs
  SMCOG1175: pyridine nucleotide-disulfide oxidoreductase

BN6628_RS13230: alcohol dehydrogenase

smcogs
  SMCOG1040: alcohol dehydrogenase

BN6628_RS13240: flavodoxin

smcogs
  SMCOG1134: flavodoxin

BN6628_RS13245: pyridine nucleotide-disulfide oxidoreductase

smcogs
  SMCOG1175: pyridine nucleotide-disulfide oxidoreductase

Transferases: PPTase acylase
BN6628_RS13080: 4'-phosphopantetheinyl transferase

smcogs
  SMCOG1012: 4'-phosphopantetheinyl transferase

BN6628_RS13130: malonyl CoA-acyl carrier protein transacylase

smcogs
  SMCOG1021: malonyl CoA-acyl carrier protein transacylase

Hydrolases: amidase esterase hydrolase
BN6628_RS13085: amidase

smcogs
  SMCOG1105: amidase

BN6628_RS13160: thioesterase

smcogs
  SMCOG1004: thioesterase

BN6628_RS13170: beta-lactamase

smcogs
  SMCOG1053: beta-lactamase

Ligases: ligase synthase
BN6628_RS13105: Beta-ketoacyl synthase

smcogs
  SMCOG1022: Beta-ketoacyl synthase

BN6628_RS13110: condensation domain-containing protein

smcogs
  SMCOG1127: condensation domain-containing protein

BN6628_RS13115: Beta-ketoacyl synthase

smcogs
  SMCOG1093: Beta-ketoacyl synthase

BN6628_RS13120: condensation domain-containing protein

smcogs
  SMCOG1127: condensation domain-containing protein

BN6628_RS13125: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

BN6628_RS13150: Beta-ketoacyl synthase

smcogs
  SMCOG1093: Beta-ketoacyl synthase

BN6628_RS13155: condensation domain-containing protein

smcogs
  SMCOG1127: condensation domain-containing protein

BN6628_RS13175: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

BN6628_RS13180: Beta-ketoacyl synthase

smcogs
  SMCOG1022: Beta-ketoacyl synthase

Translocases: transporter
BN6628_RS13065: sugar-binding lipoprotein

smcogs
  SMCOG1143: sugar-binding lipoprotein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | T1PKS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | ---
BGC0002135.2 |  |  | 0.88 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0001833.4 |  |  | 0.84 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0001050.5 |  |  | 0.82 | NRPS, PKS | thalassospiramide A | Tistrella bauzanensis
BGC0002286.3 |  |  | 0.79 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001128.4 |  |  | 0.78 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001135.5 |  |  | 0.77 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001133.4 |  |  | 0.76 | NRPS | taxlllaid A | Xenorhabdus bovienii SS-2004
BGC0001166.5 |  |  | 0.76 | NRPS | HC-toxin | Alternaria jesenskae
BGC0001132.4 |  |  | 0.75 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001261.3 |  |  | 0.75 | NRPS | AM-toxin | Alternaria alternata

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002135.2 |  | 0.75 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0001833.4 |  | 0.73 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0001050.5 |  | 0.73 | NRPS, PKS | thalassospiramide A | Tistrella bauzanensis
BGC0002286.3 |  | 0.71 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001128.4 |  | 0.71 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001135.5 |  | 0.71 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001133.4 |  | 0.70 | NRPS | taxlllaid A | Xenorhabdus bovienii SS-2004
BGC0001166.5 |  | 0.70 | NRPS | HC-toxin | Alternaria jesenskae
BGC0001132.4 |  | 0.70 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001261.3 |  | 0.70 | NRPS | AM-toxin | Alternaria alternata

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
CRP
Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 16.68 out of 19.26
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 21.21 out of 27.78
Confidence: medium
CRP
Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 16.91 out of 19.26
Confidence: medium
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 25.08 out of 29.38
Confidence: medium
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.77 out of 20.97
Confidence: medium
LexA variant 2
Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 20.18 out of 24.78
Confidence: medium
Additional weak hits (13):
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 23.95 out of 31.73
Confidence: weak
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 22.11 out of 31.73
Confidence: weak
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 21.43 out of 31.73
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 20.73 out of 28.14
Confidence: weak
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 24.21 out of 32.74
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 21.13 out of 29.38
Confidence: weak
HgtR
Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 25.01 out of 36.54
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.53 out of 29.38
Confidence: weak
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 24.74 out of 32.74
Confidence: weak
HypR
Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 18.94 out of 22.40
Confidence: weak
LuxO
Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 19.63 out of 26.12
Confidence: weak
NuR
Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 21.87 out of 30.98
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 21.56 out of 28.14
Confidence: weak
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS products
NRPS/PKS substrates
TFBS Finder
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 6, location 2828008 - 2914400:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (D-Asn) + (Val - redmal) + (ohmal) + (X) + (mal) + (Gly - Cys) + (Cys)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
BN6628_RS13105: Cys
Search NORINE for peptide: strict or relaxed
AMP-binding (1336..1732): Cys
nrpys: Cys

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Polar, uncharged (aliphatic with -SH) (Cys)
  Small clusters prediction:
    Polar, uncharged (aliphatic with -SH) (Cys)
  Single AA prediction:
    Polar, uncharged (aliphatic with -SH) (Cys)

Stachelhaus prediction details:
  Stachelhaus sequence:
    TAMSFDLSVFDGNTLLSGDISLGGATEASIWSIY
  Nearest Stachelhaus code(s):
    Cys DLFNLSLIWK (79% 8Å match)
  Stachelhaus code match:
    100% (strong)

BN6628_RS13110: Gly - Cys
Search NORINE for peptide: strict or relaxed
AMP-binding (508..903): Gly
nrpys: Gly

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
  Small clusters prediction:
    Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
  Single AA prediction:
    gly (Gly)

Stachelhaus prediction details:
  Stachelhaus sequence:
    FSMTFDIFVLELQALCGGEWNLYGPTETTVWSLA
  Nearest Stachelhaus code(s):
    Gly DILQLGLVWK (88% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (1586..1989): Cys
nrpys: Cys

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Polar, uncharged (aliphatic with -SH) (Cys)
  Small clusters prediction:
    Polar, uncharged (aliphatic with -SH) (Cys)
  Single AA prediction:
    Polar, uncharged (aliphatic with -SH) (Cys)

Stachelhaus prediction details:
  Stachelhaus sequence:
    TDISFDLSVYDGNSLLSGDVSLGGATEAAIWSIL
  Nearest Stachelhaus code(s):
    Cys DLYNLSLIWK (94% 8Å match)
  Stachelhaus code match:
    100% (strong)

BN6628_RS13115: mal
PKS_AT (537..830): mal
ATSignature: Malonyl-CoA

Top 3 matches:
  Malonyl-CoA: 91.7%
  inactive: 83.3%

minowa: Malonyl-CoA

Prediction, score:
  Malonyl-CoA: 115.1
  inactive: 73.8
  Methoxymalonyl-CoA: 53.1
  Methylmalonyl-CoA: 44.4
  Isobutyryl-CoA: 23.4
  Propionyl-CoA: 22.4
  Benzoyl-CoA: 11.3
  Ethylmalonyl-CoA: 9.3
  trans-1,2-CPDA: 0.0
  fatty_acid: 0.0
  CHC-CoA: 0.0
  Acetyl-CoA: 0.0
  3-Methylbutyryl-CoA: 0.0
  2-Methylbutyryl-CoA: 0.0

BN6628_RS13120: X
AMP-binding (501..899): X
nrpys: (unknown)

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
  Large clusters prediction:
    Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
  Small clusters prediction:
    Polar aromatic ring (Tyr, bOH-Tyr)
  Single AA prediction:
    N/A

Stachelhaus prediction details:
  Stachelhaus sequence:
    LSFTSSSFIGEPSTLSGGEVNGYGLSESGVCSTY
  Nearest Stachelhaus code(s):
    Sam ASGSLGGICK (85% 8Å match)
  Stachelhaus code match:
    80% (moderate)

BN6628_RS13125: X
AMP-binding (34..438): X
nrpys: Dab, Asp

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
  Small clusters prediction:
    ser (Ser)
  Single AA prediction:
    ser (Ser)

Stachelhaus prediction details:
  Stachelhaus sequence:
    RWMTFDVSVWEWHFFCSGEINLYGPTEATIDVTH
  Nearest Stachelhaus code(s):
    Dab or Asp DVWHFSLIDK (94% 8Å match)
    Ser DVWHFSLIDK (91% 8Å match)
  Stachelhaus code match:
    100% (strong)

BN6628_RS13130: mal
PKS_AT (7..289): mal
ATSignature: Malonyl-CoA

Top 3 matches:
  Malonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:
  Malonyl-CoA: 62.3
  Methoxymalonyl-CoA: 40.1
  inactive: 31.0
  Methylmalonyl-CoA: 28.8
  Propionyl-CoA: 11.2
  Isobutyryl-CoA: 8.2
  trans-1,2-CPDA: 0.0
  fatty_acid: 0.0
  Ethylmalonyl-CoA: 0.0
  CHC-CoA: 0.0
  Benzoyl-CoA: 0.0
  Acetyl-CoA: 0.0
  3-Methylbutyryl-CoA: 0.0
  2-Methylbutyryl-CoA: 0.0

BN6628_RS13150: mal
PKS_AT (534..828): mal
ATSignature: Malonyl-CoA

Top 3 matches:
  Malonyl-CoA: 83.3%
  inactive: 75.0%

minowa: Malonyl-CoA

Prediction, score:
  Malonyl-CoA: 129.4
  inactive: 73.8
  Methoxymalonyl-CoA: 53.6
  Methylmalonyl-CoA: 39.8
  Propionyl-CoA: 24.0
  Isobutyryl-CoA: 18.7
  Benzoyl-CoA: 14.6
  Acetyl-CoA: 10.1
  2-Methylbutyryl-CoA: 9.0
  Ethylmalonyl-CoA: 6.0
  trans-1,2-CPDA: 0.0
  fatty_acid: 0.0
  CHC-CoA: 0.0
  3-Methylbutyryl-CoA: 0.0

BN6628_RS13155: Val - mal
Search NORINE for peptide: strict or relaxed
AMP-binding (472..871): Val
nrpys: Val

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
  Small clusters prediction:
    Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
  Single AA prediction:
    N/A

Stachelhaus prediction details:
  Stachelhaus sequence:
    LNTCFDVSNFEGWMIVGGDVNGYGPSENSVLSTT
  Nearest Stachelhaus code(s):
    Ala or Val DVFWIGGTFK (62% 8Å match)
  Stachelhaus code match:
    80% (moderate)

PKS_AT (1597..1891): mal
ATSignature: Malonyl-CoA

Top 3 matches:
  Malonyl-CoA: 91.7%
  inactive: 79.2%
  2-Rhyd-Malonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:
  Malonyl-CoA: 136.1
  inactive: 78.2
  Methoxymalonyl-CoA: 45.4
  Methylmalonyl-CoA: 37.2
  Propionyl-CoA: 21.8
  Ethylmalonyl-CoA: 13.8
  fatty_acid: 11.8
  2-Methylbutyryl-CoA: 10.0
  trans-1,2-CPDA: 0.0
  Isobutyryl-CoA: 0.0
  CHC-CoA: 0.0
  Benzoyl-CoA: 0.0
  Acetyl-CoA: 0.0
  3-Methylbutyryl-CoA: 0.0

BN6628_RS13175: Asn
Search NORINE for peptide: strict or relaxed
AMP-binding (464..861): Asn
nrpys: Asn

SVM prediction details:
  Predicted physicochemical class:
    hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
  Large clusters prediction:
    Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
  Small clusters prediction:
    asp,asn (Asp, Asn)
  Single AA prediction:
    asn (Asn)

Stachelhaus prediction details:
  Stachelhaus sequence:
    YWASFDLTLTSVKLIVGGEYNEYGPTEATVGCMV
  Nearest Stachelhaus code(s):
    Asn DLTKIGEVGK (85% 8Å match)
  Stachelhaus code match:
    100% (strong)

Link to PARAS substrate predictor
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CRP | Cyclic AMP receptor protein
CcpA | Catabolite control protein A
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
FuR variant 1 | Ferric Uptake Regulator
LexA variant 2 | Repressor of DNA damage response

NZ_LT575476.1 - Region 7 - NI-siderophore
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,915,656 - 2,947,253 nt. (total: 31,598 nt) Show pHMM detection rules used
NI-siderophore: IucA_IucC

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: oxidoreductase reductase
BN6628_RS13280: alkyl hydroperoxide reductase subunit

smcogs
  SMCOG1176: alkyl hydroperoxide reductase subunit

BN6628_RS13370: dihydropteridine reductase

smcogs
  SMCOG1159: dihydropteridine reductase

Transferases: aminotransferase
BN6628_RS13295: aminotransferase

smcogs
  SMCOG1019: aminotransferase

BN6628_RS13305: aminotransferase

smcogs
  SMCOG1019: aminotransferase

Hydrolases: deaminase
BN6628_RS13325: ornithine cyclodeaminase

smcogs
  SMCOG1158: ornithine cyclodeaminase

Lyases: decarboxylase
BN6628_RS13310: diaminopimelate decarboxylase

smcogs
  SMCOG1264: diaminopimelate decarboxylase

Ligases: synthase
BN6628_RS13330: cysteine synthase

smcogs
  SMCOG1081: cysteine synthase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NI-siderophore | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000946.5 |  | 0.59 | other (other) | vibrioferrin | Vibrio parahaemolyticus
BGC0001870.3 |  | 0.54 | other (other) | putrebactin, avaroferrin | Xenorhabdus budapestensis
BGC0000943.5 |  | 0.54 | other (other) | staphyloferrin B | Staphylococcus aureus subsp. aureus NCTC 8325
BGC0002527.2 |  | 0.52 | other (other) | vibrioferrin | Azotobacter vinelandii CA
BGC0001408.5 |  | 0.52 | other (other) | xanthoferrin | Xanthomonas oryzae pv. oryzae KACC 10331
BGC0000941.3 |  | 0.51 | other (other) | desferrioxamin B | Streptomyces griseus subsp. griseus NBRC 13350
BGC0002683.2 |  | 0.51 | NRPS | schizokinen | Nostoc sp. PCC 7120 = FACHB-418
BGC0002073.3 |  | 0.50 | NRPS | dehydroxynocardamine | Corynebacterium propinquum
BGC0001499.5 |  | 0.50 | other (other) | aerobactin | Pantoea ananatis
BGC0001531.5 |  | 0.50 | other (other) | bisucaberin B | Tenacibaculum mesophilum

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000946.5 |  | 0.59 | other (other) | vibrioferrin | Vibrio parahaemolyticus
BGC0001870.3 |  | 0.54 | other (other) | putrebactin, avaroferrin | Xenorhabdus budapestensis
BGC0000943.5 |  | 0.54 | other (other) | staphyloferrin B | Staphylococcus aureus subsp. aureus NCTC 8325
BGC0002527.2 |  | 0.52 | other (other) | vibrioferrin | Azotobacter vinelandii CA
BGC0001408.5 |  | 0.52 | other (other) | xanthoferrin | Xanthomonas oryzae pv. oryzae KACC 10331
BGC0000941.3 |  | 0.51 | other (other) | desferrioxamin B | Streptomyces griseus subsp. griseus NBRC 13350
BGC0002683.2 |  | 0.51 | NRPS | schizokinen | Nostoc sp. PCC 7120 = FACHB-418
BGC0002073.3 |  | 0.50 | NRPS | dehydroxynocardamine | Corynebacterium propinquum
BGC0001499.5 |  | 0.50 | other (other) | aerobactin | Pantoea ananatis
BGC0001531.5 |  | 0.50 | other (other) | bisucaberin B | Tenacibaculum mesophilum

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.01 out of 26.06
Confidence: medium
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 29.38 out of 29.38
Confidence: strong
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 27.77 out of 29.38
Confidence: strong
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 29.38 out of 29.38
Confidence: strong
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 26.61 out of 29.38
Confidence: strong
PsrA
Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 23.52 out of 25.88
Confidence: strong
ArcA
Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.26 out of 21.55
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.58 out of 26.06
Confidence: medium
CatR
Description: H2O2-responsive repressor
Species: Streptomyces coelicolor
Score: 20.57 out of 25.31
Confidence: medium
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 24.93 out of 29.38
Confidence: medium
GnfM
Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 22.57 out of 27.55
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.29 out of 26.06
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.98 out of 28.19
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.98 out of 28.19
Confidence: medium
Additional weak hits (19):
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 22.12 out of 28.14
Confidence: weak
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 23.49 out of 31.73
Confidence: weak
HipB
Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 25.17 out of 33.73
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.38 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.68 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.79 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.29 out of 26.06
Confidence: weak
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 20.84 out of 29.25
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 21.08 out of 29.38
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.53 out of 29.38
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 21.80 out of 28.14
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 21.80 out of 28.14
Confidence: weak
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 22.67 out of 32.74
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 21.80 out of 28.14
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 21.80 out of 28.14
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 21.29 out of 29.38
Confidence: weak
ZuR variant 2
Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 24.12 out of 33.14
Confidence: weak
CsoR
Description: Copper-responsive repressor
Species: Streptomyces lividans
Score: 21.77 out of 32.38
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.15 out of 26.06
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
ArcA | Repressor of carbon oxidation
CatR | H2O2-responsive repressor
FuR variant 1 | Ferric Uptake Regulator
GnfM | Regulator of nitrogen-fixation genes
MogR | Repressor of flagellar motility genes
PsrA | Oleic acid responsive regulator
ZuR variant 1 | Zinc-responsive repressor

NZ_LT575476.1 - Region 8 - NRPS,transAT-PKS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 3,023,223 - 3,091,221 nt. (total: 67,999 nt) Show pHMM detection rules used
transAT-PKS: (cds(PKS_AT and not (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) and (cds(ATd and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) or cds(tra_KS and PP-binding)))
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS modules
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase
BN6628_RS13845: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

Transferases: acylase acyltransferase
BN6628_RS13745: malonyl CoA-acyl carrier protein transacylase

smcogs
  SMCOG1021: malonyl CoA-acyl carrier protein transacylase

BN6628_RS13780: polyketide synthase associated protein papA3

smcogs
  SMCOG1209: polyketide synthase associated protein papA3

Hydrolases: deacetylase esterase
BN6628_RS13740: acetylornithine deacetylase

smcogs
  SMCOG1247: acetylornithine deacetylase

BN6628_RS13750: thioesterase

smcogs
  SMCOG1004: thioesterase

Ligases: synthase
BN6628_RS13760: Beta-ketoacyl synthase

smcogs
  SMCOG1022: Beta-ketoacyl synthase

Translocases: permease transporter
BN6628_RS13695: sugar-binding lipoprotein

smcogs
  SMCOG1143: sugar-binding lipoprotein

BN6628_RS13735: phenylalanine-specific permease

smcogs
  SMCOG1038: phenylalanine-specific permease

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | transAT-PKS | NRPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | ---
BGC0002135.2 |  |  | 0.85 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0001833.4 |  |  | 0.82 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0001758.4 |  |  | 0.80 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0001135.5 |  |  | 0.80 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001128.4 |  |  | 0.77 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3 |  |  | 0.75 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001825.4 |  |  | 0.74 | NRPS | xenematide | Xenorhabdus nematophila AN6/1
BGC0001132.4 |  |  | 0.73 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0000342.4 |  |  | 0.71 | NRPS | enniatin | Fusarium equiseti
BGC0000307.4 |  |  | 0.70 | NRPS | AbT1 | Aureobasidium pullulans

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002135.2 |  | 0.74 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0001833.4 |  | 0.73 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0001758.4 |  | 0.72 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0001135.5 |  | 0.72 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001128.4 |  | 0.71 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3 |  | 0.70 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001825.4 |  | 0.70 | NRPS | xenematide | Xenorhabdus nematophila AN6/1
BGC0001132.4 |  | 0.69 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0000342.4 |  | 0.68 | NRPS | enniatin | Fusarium equiseti
BGC0000307.4 |  | 0.68 | NRPS | AbT1 | Aureobasidium pullulans

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 23.31 out of 30.25
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.13 out of 27.78
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.70 out of 27.78
Confidence: medium
GnfM
Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 21.35 out of 27.55
Confidence: medium
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 25.55 out of 30.25
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.24 out of 27.78
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.45 out of 27.78
Confidence: medium
NuR
Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 26.36 out of 30.98
Confidence: medium
Additional weak hits (11):
ANR
Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 19.99 out of 26.33
Confidence: weak
ArgR
Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 17.16 out of 20.01
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.13 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 19.61 out of 26.06
Confidence: weak
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 20.44 out of 29.25
Confidence: weak
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 22.49 out of 32.74
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.29 out of 26.06
Confidence: weak
HipB
Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 22.23 out of 33.73
Confidence: weak
CopR
Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 20.95 out of 30.97
Confidence: weak
HgtR
Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 24.86 out of 36.54
Confidence: weak
RutR
Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.50 out of 26.85
Confidence: weak
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS products
NRPS/PKS substrates
TFBS Finder
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 8, location 3023222 - 3091221:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (fatty_acid - Ile - Ser - Ser) + (mal - Met - Gly)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
BN6628_RS13745: mal
PKS_AT (8..290): mal
ATSignature: Malonyl-CoA

Top 3 matches:
  Malonyl-CoA: 83.3%
  2-Methylbutyryl-CoA: 58.3%
  inactive: 54.2%

minowa: Malonyl-CoA

Prediction, score:
  Malonyl-CoA: 105.2
  Methoxymalonyl-CoA: 38.6
  Methylmalonyl-CoA: 37.5
  Propionyl-CoA: 33.8
  inactive: 31.3
  CHC-CoA: 20.3
  2-Methylbutyryl-CoA: 18.5
  Ethylmalonyl-CoA: 17.5
  Isobutyryl-CoA: 11.4
  trans-1,2-CPDA: 0.0
  fatty_acid: 0.0
  Benzoyl-CoA: 0.0
  Acetyl-CoA: 0.0
  3-Methylbutyryl-CoA: 0.0

BN6628_RS13760: Met - Gly
Search NORINE for peptide: strict or relaxed
AMP-binding (1250..1654): Met
nrpys: Met

SVM prediction details:
  Predicted physicochemical class:
    N/A
  Large clusters prediction:
    N/A
  Small clusters prediction:
    N/A
  Single AA prediction:
    N/A

Stachelhaus prediction details:
  Stachelhaus sequence:
    FSLTFDVSVAEMYLLVGVEINGYGPTETTVCSNM
  Nearest Stachelhaus code(s):
    Met DVFYLGGVFK (76% 8Å match)
  Stachelhaus code match:
    80% (moderate)

AMP-binding (2349..2741): Gly
nrpys: Gly

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
  Small clusters prediction:
    N/A
  Single AA prediction:
    gly (Gly)

Stachelhaus prediction details:
  Stachelhaus sequence:
    FGFAFDIFVVELQIMIGAEFNLYGPTETTVWTSI
  Nearest Stachelhaus code(s):
    Gly DILQMGMVWK (71% 8Å match)
  Stachelhaus code match:
    80% (moderate)

BN6628_RS13780: fatty_acid - Ile - Ser - Ser
Search NORINE for peptide: strict or relaxed
CAL_domain (155..468): fatty_acid
minowa: fatty_acid

Prediction, score:
  fatty_acid: 108.6
  shikimic_acid: 0.0
  Acetyl-CoA: 0.0
  AHBA: 0.0
  NH2: -1.8

AMP-binding (1143..1551): Ile
nrpys: Ile

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
  Small clusters prediction:
    Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
  Single AA prediction:
    ile (Ile)

Stachelhaus prediction details:
  Stachelhaus sequence:
    IHTSFDGSTFDGFVLFGGELHVYGPTETTVFATS
  Nearest Stachelhaus code(s):
    Ile DGFFLGVVFK (85% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (2193..2604): Ser
nrpys: Ser

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
  Small clusters prediction:
    ser (Ser)
  Single AA prediction:
    ser (Ser)

Stachelhaus prediction details:
  Stachelhaus sequence:
    RWMTFDVSVWEWHFFSSGEINLYGPTEATVDVSY
  Nearest Stachelhaus code(s):
    Ser DVWHFSLVDK (97% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (3257..3665): Ser
nrpys: Ser

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
  Small clusters prediction:
    ser (Ser)
  Single AA prediction:
    ser (Ser)

Stachelhaus prediction details:
  Stachelhaus sequence:
    RWMTFDVSVWEWHFFASGEVNLYGPTEATVDVSY
  Nearest Stachelhaus code(s):
    Ser DVWHFSLVDK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

Link to PARAS substrate predictor
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
ColR | Phenol-responsive regulator
GnfM | Regulator of nitrogen-fixation genes
NuR | Nickel-responsive regulator

NZ_LT575476.1 - Region 9 - cyclic-lactone-autoinducer
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 3,763,404 - 3,783,934 nt. (total: 20,531 nt) Show pHMM detection rules used
cyclic-lactone-autoinducer: (TIGR04223 or AgrB)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Isomerases: mutase
BN6628_RS16910: phosphoglycerate mutase

smcogs
  SMCOG1101: phosphoglycerate mutase

Translocases: transport
BN6628_RS16920: MMPL domain-containing transport protein

smcogs
  SMCOG1035: MMPL domain-containing transport protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | cyclic-lactone-autoinducer | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000779.3 |  | 0.42 | saccharide | lipopolysaccharide | Aeromonas piscicola
BGC0002381.3 |  | 0.26 | PKS, other (other) | tambjamine BE-18591 | Streptomyces albus subsp. albus
BGC0000982.5 |  | 0.26 | NRPS, PKS | cystothiazole A | Cystobacter fuscus
BGC0000203.3 |  | 0.24 | PKS | BE-7585A | Amycolatopsis orientalis subsp. vinearia
BGC0000780.3 |  | 0.23 | saccharide | O&K-antigen | Vibrio parahaemolyticus
BGC0002109.3 |  | 0.19 | NRPS | kitacinnamycin A, kitacinnamycin B, kitacinnamycin C, kitacinnamycin D, kitacinnamycin E, kitacinnamycin F | Kitasatospora sp.

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000779.3 |  | 0.42 | saccharide | lipopolysaccharide | Aeromonas piscicola
BGC0002381.3 |  | 0.26 | PKS, other (other) | tambjamine BE-18591 | Streptomyces albus subsp. albus
BGC0000982.5 |  | 0.26 | NRPS, PKS | cystothiazole A | Cystobacter fuscus
BGC0000203.3 |  | 0.24 | PKS | BE-7585A | Amycolatopsis orientalis subsp. vinearia
BGC0000780.3 |  | 0.23 | saccharide | O&K-antigen | Vibrio parahaemolyticus
BGC0002109.3 |  | 0.19 | NRPS | kitacinnamycin A, kitacinnamycin B, kitacinnamycin C, kitacinnamycin D, kitacinnamycin E, kitacinnamycin F | Kitasatospora sp.

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
IolR
Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 20.37 out of 23.79
Confidence: medium
LexA variant 2
Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 23.10 out of 24.78
Confidence: strong
CatR
Description: H2O2-responsive repressor
Species: Streptomyces coelicolor
Score: 21.45 out of 25.31
Confidence: medium
Additional weak hits (3):
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.96 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.86 out of 26.06
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 21.91 out of 28.14
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CatR | H2O2-responsive repressor
IolR | Regulator of the inositol catabolism
LexA variant 2 | Repressor of DNA damage response

NZ_LT575476.1 - Region 10 - ranthipeptide
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 3,895,135 - 3,916,423 nt. (total: 21,289 nt) Show pHMM detection rules used
ranthipeptide: (TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085 or SPASM)) and minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716 or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or (YcaO or TIGR03604))))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: oxygenase
BN6628_RS17415: monooxygenase FAD-binding

smcogs
  SMCOG1050: monooxygenase FAD-binding

Hydrolases: protease
BN6628_RS17470: alkaline serine protease, subtilase family

smcogs
  SMCOG1075: alkaline serine protease, subtilase family

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | ranthipeptide | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002306.2 |  | 0.51 | ribosomal | freyrasin | Paenibacillus polymyxa ATCC 842
BGC0000600.3 |  | 0.46 | ribosomal | thurincin H | Bacillus thuringiensis
BGC0002698.2 |  | 0.46 | ribosomal | phaeornamide | Pseudophaeobacter arcticus DSM 23566
BGC0001552.3 |  | 0.44 | ribosomal | citrulassin F | Streptomyces avermitilis MA-4680 = NBRC 14893
BGC0001550.3 |  | 0.44 | ribosomal | citrulassin D | Streptomyces katrae
BGC0000504.5 |  | 0.43 | ribosomal | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1
BGC0001549.3 |  | 0.43 | ribosomal | citrulassin B | Streptomyces aurantiacus JA 4570
BGC0002289.2 |  | 0.43 | ribosomal | Leepeptin | Streptomyces leeuwenhoekii
BGC0000500.5 |  | 0.43 | ribosomal | carnolysin A1, carnolysin A2 | Carnobacterium maltaromaticum
BGC0001789.3 |  | 0.42 | ribosomal | suicin 90-1330 | Streptococcus suis

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002306.2 |  | 0.51 | ribosomal | freyrasin | Paenibacillus polymyxa ATCC 842
BGC0000600.3 |  | 0.46 | ribosomal | thurincin H | Bacillus thuringiensis
BGC0002698.2 |  | 0.46 | ribosomal | phaeornamide | Pseudophaeobacter arcticus DSM 23566
BGC0001552.3 |  | 0.44 | ribosomal | citrulassin F | Streptomyces avermitilis MA-4680 = NBRC 14893
BGC0001550.3 |  | 0.44 | ribosomal | citrulassin D | Streptomyces katrae
BGC0000504.5 |  | 0.43 | ribosomal | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1
BGC0001549.3 |  | 0.43 | ribosomal | citrulassin B | Streptomyces aurantiacus JA 4570
BGC0002289.2 |  | 0.43 | ribosomal | Leepeptin | Streptomyces leeuwenhoekii
BGC0000500.5 |  | 0.43 | ribosomal | carnolysin A1, carnolysin A2 | Carnobacterium maltaromaticum
BGC0001789.3 |  | 0.42 | ribosomal | suicin 90-1330 | Streptococcus suis

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.57 out of 18.57
Confidence: strong
NtrC
Description: Nitrogen regulatory protein C
Species: Pseudomonas putida KT2440
Score: 21.83 out of 29.72
Confidence: medium
CRP
Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 18.06 out of 19.26
Confidence: strong
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.16 out of 28.19
Confidence: medium
LexA variant 2
Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 23.87 out of 24.78
Confidence: strong
Additional weak hits (1):
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.53 out of 30.25
Confidence: weak
RREFinder
TFBS Finder
RRE predictions
RREfinder results sidepanel.

ranthipeptide protocluster (3895134...3916423)
BN6628_RS17460
  RRE type: Stand_Alone_Lasso_RRE
  Location: 12 - 90
  Score: 35.1

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CRP | Cyclic AMP receptor protein
LexA variant 2 | Repressor of DNA damage response
NtrC | Nitrogen regulatory protein C
ToxT | Regulator of MSHA biosynthesis
ZuR variant 1 | Zinc-responsive repressor

NZ_LT575476.1 - Region 11 - RRE-containing
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 4,037,317 - 4,058,921 nt. (total: 21,605 nt) Show pHMM detection rules used
RRE-containing: minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE])

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Hydrolases: hydrolase
BN6628_RS18135: beta-lactamase

smcogs
  SMCOG1053: beta-lactamase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | RRE-containing | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002306.2 |  | 0.49 | ribosomal | freyrasin | Paenibacillus polymyxa ATCC 842
BGC0000623.3 |  | 0.43 | ribosomal | plantaricin W α, plantaricin W β | Lactobacillus plantarum
BGC0000600.3 |  | 0.41 | ribosomal | thurincin H | Bacillus thuringiensis
BGC0000551.5 |  | 0.41 | ribosomal | SapB | Streptomyces coelicolor A3(2)
BGC0000626.3 |  | 0.41 | ribosomal | thuricin | Bacillus thuringiensis
BGC0000486.4 |  | 0.41 | ribosomal | butyrivibriocin AR10 | Butyrivibrio fibrisolvens
BGC0002700.2 |  | 0.41 | ribosomal | bacinapeptin | Bacillus nakamurai
BGC0000554.4 |  | 0.41 | ribosomal | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0002667.2 |  | 0.40 | ribosomal | estericin A | Clostridium estertheticum
BGC0001210.5 |  | 0.40 | ribosomal | pseudomycoicidin | Bacillus pseudomycoides DSM 12442

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002306.2 |  | 0.49 | ribosomal | freyrasin | Paenibacillus polymyxa ATCC 842
BGC0000623.3 |  | 0.43 | ribosomal | plantaricin W α, plantaricin W β | Lactobacillus plantarum
BGC0000600.3 |  | 0.41 | ribosomal | thurincin H | Bacillus thuringiensis
BGC0000551.5 |  | 0.41 | ribosomal | SapB | Streptomyces coelicolor A3(2)
BGC0000626.3 |  | 0.41 | ribosomal | thuricin | Bacillus thuringiensis
BGC0000486.4 |  | 0.41 | ribosomal | butyrivibriocin AR10 | Butyrivibrio fibrisolvens
BGC0002700.2 |  | 0.41 | ribosomal | bacinapeptin | Bacillus nakamurai
BGC0000554.4 |  | 0.41 | ribosomal | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0002667.2 |  | 0.40 | ribosomal | estericin A | Clostridium estertheticum
BGC0001210.5 |  | 0.40 | ribosomal | pseudomycoicidin | Bacillus pseudomycoides DSM 12442

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57
Confidence: strong
CRP
Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 17.40 out of 19.26
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.98 out of 27.78
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.13 out of 26.06
Confidence: medium
IolR
Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 19.68 out of 23.79
Confidence: medium
NrtR
Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 29.43 out of 35.63
Confidence: medium
Additional weak hits (5):
ArcA
Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 18.48 out of 21.55
Confidence: weak
CelR
Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 20.05 out of 30.11
Confidence: weak
CopR
Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 23.71 out of 30.97
Confidence: weak
BldD
Description: Development and antibiotic global regulator
Species: Streptomyces coelicolor
Score: 19.24 out of 23.43
Confidence: weak
LexA variant 1
Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 21.71 out of 29.65
Confidence: weak
RREFinder
TFBS Finder
RRE predictions
RREfinder results sidepanel.

RRE-containing protocluster (4037316...4058921)
BN6628_RS18125
  RRE type: Other_Sactipeptide_rSAM_RRE
  Location: 22 - 101
  Score: 36.4

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CRP | Cyclic AMP receptor protein
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
IolR | Regulator of the inositol catabolism
MogR | Repressor of flagellar motility genes
NrtR | NAD synthesis repressor
ToxT | Regulator of MSHA biosynthesis

NZ_LT575476.1 - Region 12 - phosphonate
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 4,203,608 - 4,216,776 nt. (total: 13,169 nt) Show pHMM detection rules used
phosphonate: (phosphonates and minimum(1, [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF, CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2, NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C, TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase or phosphonatesMeIsocitrateLyase))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: oxidase
BN6628_RS18755: pyruvate oxidase/decarboxylase

smcogs
  SMCOG1055: pyruvate oxidase/decarboxylase

Transferases: aminotransferase
BN6628_RS18750: aminotransferase class V

smcogs
  SMCOG1139: aminotransferase class V

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | phosphonate | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001859.4 |  | 0.45 | other (phosphonate) | fosfomycin | Pseudomonas syringae
BGC0000904.5 |  | 0.42 | other (other) | FR-900098 | Streptomyces rubellomurinus
BGC0002036.4 |  | 0.42 | other (other) | dehydrofosmidomycin | Streptomyces lavendulae
BGC0001739.3 |  | 0.40 | other (other) | phosphonoacetic Acid | Streptomyces sp. NRRL F-525
BGC0000926.5 |  | 0.39 | other (other) | rhizocticin A | Bacillus subtilis subsp. spizizenii ATCC 6633
BGC0000897.5 |  | 0.38 | other (other) | dehydrophos | Streptomyces luridus
BGC0002670.2 |  | 0.38 | other (other) | fosfonochlorin | Fusarium oxysporum f. sp. lycopersici 4287
BGC0000937.5 |  | 0.35 | other (other) | fosfazinomycin A, fosfazinomycin B | Streptomyces sp. WM6372
BGC0000938.5 |  | 0.33 | other (aminocoumarin) | fosfomycin | Streptomyces fradiae
BGC0001411.3 |  | 0.32 | saccharide | polysaccharide B | Bacteroides fragilis

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001859.4 |  | 0.45 | other (phosphonate) | fosfomycin | Pseudomonas syringae
BGC0000904.5 |  | 0.42 | other (other) | FR-900098 | Streptomyces rubellomurinus
BGC0002036.4 |  | 0.42 | other (other) | dehydrofosmidomycin | Streptomyces lavendulae
BGC0001739.3 |  | 0.40 | other (other) | phosphonoacetic Acid | Streptomyces sp. NRRL F-525
BGC0000926.5 |  | 0.39 | other (other) | rhizocticin A | Bacillus subtilis subsp. spizizenii ATCC 6633
BGC0000897.5 |  | 0.38 | other (other) | dehydrophos | Streptomyces luridus
BGC0002670.2 |  | 0.38 | other (other) | fosfonochlorin | Fusarium oxysporum f. sp. lycopersici 4287
BGC0000937.5 |  | 0.35 | other (other) | fosfazinomycin A, fosfazinomycin B | Streptomyces sp. WM6372
BGC0000938.5 |  | 0.33 | other (aminocoumarin) | fosfomycin | Streptomyces fradiae
BGC0001411.3 |  | 0.32 | saccharide | polysaccharide B | Bacteroides fragilis

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.53 out of 20.97
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 23.01 out of 28.19
Confidence: medium
AbrC3
Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 17.05 out of 18.16
Confidence: strong
Additional weak hits (5):
RutR
Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.68 out of 26.85
Confidence: weak
LuxO
Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 19.80 out of 26.12
Confidence: weak
CelR
Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 21.21 out of 30.11
Confidence: weak
CelR
Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 21.70 out of 30.11
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.88 out of 26.06
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
AbrC3 | Antibiotic production activator
CcpA | Catabolite control protein A
ZuR variant 1 | Zinc-responsive repressor