LOCUS       NZ_LN850107            10348 bp    DNA     linear   CON 13-AUG-2024
DEFINITION  Alloactinosynnema sp. L-07 isolate Alloactinosynnema sp. L-07
            chromosome I.
ACCESSION   NZ_LN850107
VERSION     NZ_LN850107.1
KEYWORDS    RefSeq.
SOURCE      Alloactinosynnema sp. L-07
  ORGANISM  Alloactinosynnema sp. L-07
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae.
REFERENCE   1
  AUTHORS   Ramaraj,Thiru.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAY-2015) National Center for Genome Resources (NCGR),
            National Center for Genome Resources (NCGR), 2935 Rodeo Park Drive
            East, Santa Fe, New Mexico, 87505, USA
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_900070365.1-RS_2024_08_13
            Annotation Date                   :: 08/13/2024 03:00:54
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,999
            CDSs (total)                      :: 6,934
            Genes (coding)                    :: 6,831
            CDSs (with protein)               :: 6,831
            Genes (RNA)                       :: 65
            rRNAs                             :: 3, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 3, 3, 3 (5S, 16S, 23S)
            tRNAs                             :: 53
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 103
            CDSs (without protein)            :: 103
            Pseudo Genes (ambiguous residues) :: 0 of 103
            Pseudo Genes (frameshifted)       :: 30 of 103
            Pseudo Genes (incomplete)         :: 83 of 103
            Pseudo Genes (internal stop)      :: 1 of 103
            Pseudo Genes (multiple problems)  :: 11 of 103
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 08:22:15
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 6748414
            Orig. end                         :: 6758762
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            LN850107.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..10348
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="melanin"
                     /region_number="31"
                     /rules="melC"
                     /tool="antismash"
     cand_cluster    1..10348
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="melC"
                     /kind="single"
                     /product="melanin"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10348
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:5348](-)"
                     /cutoff="20000"
                     /detection_rule="melC"
                     /neighbourhood="5000"
                     /product="melanin"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..5348)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="melC"
                     /neighbourhood="5000"
                     /product="melanin"
                     /protocluster_number="1"
     misc_feature    561..575
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: strong, score: 19.35"
                     /tool="antismash"
     misc_feature    801..810
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 18.07"
                     /tool="antismash"
     gene            complement(906..1589)
                     /locus_tag="BN1701_RS30875"
     CDS             complement(906..1589)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="BN1701_RS30875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_197672154.1"
                     /transl_table=11
                     /translation="MTTDADLALDTSGLADSPEISATMRAAGFKAGRNPGSWLADGDIA
                     VDIMVVPHQAGTTSKTARAGRIPNHDRETSRITSGLEPALVDKSWHMIGAMDEKDSRKI
                     SVQVAGPAALLIAKAIKIEERLADAANGREARLKEKDALDMFRLLQAVETEDLVDGIHR
                     HVADDHARPVTERGLRVIRDHGTDPRFDLPKLASLAAAGDATVAPSFAALASDLIRTLG
                     LNWHH"
     gene            complement(1737..2816)
                     /locus_tag="BN1701_RS30880"
     CDS             complement(1737..2816)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="BN1701_RS30880"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_054056273.1"
                     /transl_table=11
                     /translation="MRRNGHLYETSILGPALATLRANLPDRWYATLIMPKPDTPSDAAV
                     RIGNDSGVEVTFMIEAGSTRMSSTQTATHLSALAAASPHRLLFVTDYINAPLRLACEAR
                     GINYLDATGWTYIVSNEPPILIRLTGAEKPPHQRENKSTARLNGPAAGRIIRRLLDSDP
                     PVGIRQLAALSFSSPAAVSKLMPALIAAGAIDRDADGTIVRVRRRALLNRWTKDYSFLN
                     SNGVTLDYVAPRGLQRLIEHVRDRDDICMTGSAAARTYLPSTSISVIPLTLLAMYAQDP
                     RTLAKELGLVRVGRESSNVIIAPLREPSLLDQSRLSEQGLVAPLGQVLADLLTLPGRMA
                     QEAEQLMDFLSETDLAWRE"
     misc_feature    complement(2109..2111)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(2133..2135)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(2556..2558)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            2824..2961
                     /locus_tag="BN1701_RS36155"
     CDS             2824..2961
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="BN1701_RS36155"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_157368306.1"
                     /transl_table=11
                     /translation="MLVLETAIVQSLVGLTGTGWRRLQASERLDIALKVADLLGAHAGQ
                     "
     gene            2991..3194
                     /locus_tag="BN1701_RS30885"
     CDS             2991..3194
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005157307.1"
                     /locus_tag="BN1701_RS30885"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="CopG family transcriptional regulator"
                     /protein_id="WP_054054673.1"
                     /transl_table=11
                     /translation="MAMTLRLTEEQERALALLAEAQGVSKHEAAVRAITESAARRVRDK
                     RVCALSREGRERYASLLDRLAQ"
     gene            3194..3616
                     /locus_tag="BN1701_RS30890"
     CDS             3194..3616
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005447898.1"
                     /locus_tag="BN1701_RS30890"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="type II toxin-antitoxin system death-on-curing
                     family toxin"
                     /protein_id="WP_054056274.1"
                     /transl_table=11
                     /translation="MVEYLTLDDLLTLTVDLGVPNVRDLGLLDSAAHRPQSSLMGQDAY
                     PTLDEKAAVLLESIARNHPLIDGNKRLAWMATFVCYGLNGVDLDAPEDDAYDLVIGVST
                     GTVDYRTAAGVLGGWARPEVAAPRGSGEFRLDGTVE"
     misc_feature    3630..3645
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 18.5"
                     /tool="antismash"
     gene            3791..4951
                     /locus_tag="BN1701_RS30895"
     CDS             3791..4951
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020633270.1"
                     /locus_tag="BN1701_RS30895"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="alkaline phosphatase PhoX"
                     /protein_id="WP_054054675.1"
                     /transl_table=11
                     /translation="MERRNFLRAAVIGGAATAFGGAAWAPAFAAPAQPGPGPYGPLQAA
                     DANGIMLPSGFTSRVIARSGQLVTGTSYPWHPAPDGGAVFADGTGWIYVSNSEVSSTGG
                     VGAVKFNSSGTITGAYRTLSNTNVNCAGGATPWNTWLSCEEVSLGRVYETDPWGVNPAV
                     SRPAMGRFKHEACAADADHGYIYMTEDTSDGCFYRFRPTTWGNLTSGTLEVMKGTNSQT
                     SGSVTWGVVPDPDGSPTATRNQVSGAKRFNGGEGCVYAAGTCWFTTKGDNRVWAYDANT
                     STIELAYDDSLVVGGGAPLTGVDNITRAGSGDLYVAEDGGNLEICLITPDDIVAVFLRV
                     TGQSSSEITGPAFTPNGQRLYFSSQRGTSGSSSGGITYEVTGPFRS"
     gene            complement(5001..5348)
                     /locus_tag="BN1701_RS30900"
     CDS             complement(5001..5348)
                     /GO_function="GO:0005507 - copper ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0042438 - melanin biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     melanin: melC"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF017995.4"
                     /locus_tag="BN1701_RS30900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="tyrosinase family oxidase copper chaperone"
                     /protein_id="WP_054054676.1"
                     /sec_met_domain="melC (E-value: 5.5e-18, bitscore: 64.0,
                     seeds: 38, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRTLLAGAALAVAACALTPAAAMAAPQTATCTPSFFAERYEGKTI
                     HIIDRCQSEPGWVRYTVFINGRELGVDKLEGDMGYLSVINAYDVTPTLKDTARNAVDTL
                     GPDGELAPFRP"
     gene            complement(5428..5736)
                     /locus_tag="BN1701_RS30905"
     CDS             complement(5428..5736)
                     /EC_number="4.2.1.96"
                     /GO_function="GO:0008124 -
                     4-alpha-hydroxytetrahydrobiopterin dehydratase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006729 - tetrahydrobiopterin biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018683972.1"
                     /locus_tag="BN1701_RS30905"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="4a-hydroxytetrahydrobiopterin dehydratase"
                     /protein_id="WP_054054679.1"
                     /transl_table=11
                     /translation="MPELLSDKDIGVALGTLPDWKLKDGALVRVVEFDGFPQAIQVVNR
                     IAEIAENDNHHPDIDIRWRTLTFRCSTHSAGGVTALDVTMAEEIDGVVDTVRGPDGR"
     regulatory      5771..5879
                     /bound_moiety="thiamine pyrophosphate"
                     /db_xref="RFAM:RF00059"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:14.4:RF00059"
                     /inference="COORDINATES: profile:INFERNAL:1.1.5"
                     /note="TPP riboswitch; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /regulatory_class="riboswitch"
     gene            5903..6934
                     /locus_tag="BN1701_RS30910"
     CDS             5903..6934
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015098274.1"
                     /locus_tag="BN1701_RS30910"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="thiamine ABC transporter substrate binding
                     subunit"
                     /protein_id="WP_054054681.1"
                     /transl_table=11
                     /translation="MRKFVAIAAAVLMTASCSLFGSEESGGDGKVVLVTHDSFEFDQAV
                     FDKFKTDTGITIEVRKSGDAGALTNQLVLTKSSPLGDIAFGVDNTFASRALTEGVFAEY
                     RSPEADKGPQRFAIDDTGRLTAVDTGDVCVNVDPAGLTARGLTAPATFEDLADPKFKDL
                     LVVEDPATSSPGLAFLLATVAQYGQKDWVGYWNRLKANGVKVVAGWEEAYTQEFSGSSG
                     KGPRPLVVSYASSPSAEVDEAGKPRTAALLDTCFRQVEYAGVLAGAKNTDGARKVLDLL
                     LSESFQAKVPEKMYVYPARDGVALPAAWAAAPAPQSPATMAAADIQANRERWIEQWRTA
                     VRG"
     gene            7003..8616
                     /locus_tag="BN1701_RS30915"
     CDS             7003..8616
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /GO_process="GO:0006826 - iron ion transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1214:
                     binding-protein-dependent transport systems"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004558838.1"
                     /locus_tag="BN1701_RS30915"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter permease"
                     /protein_id="WP_369800683.1"
                     /transl_table=11
                     /translation="MGAAARRPPQGTGALLAALVPLGFLAVFFLWPVAAIVQRGLSSGG
                     VGRVLAAADTWSLVLFTLAQAAASTLVAVIAALPVAFLLARCALPGMAVVRAVILVPFV
                     LPTVVVGLAFRSLLPDGGVLAIVLANAFFNVAVVARTVSGLWAHLDRRAEDAARSLGAS
                     PLRAFVSVTLPALRPAIGSSAAVVFLFCATSFGVVLLLGGARYRTLETEIYLRTVELLD
                     LSGAAALSLIQVTAVVAVLVLAAVARRRRETAMTLRPRTETARRPRGREWGVVAGAYAV
                     VAALLVPILALVLRSVSTEDGWGLDGYRALSGTGFRGSLQVSGIDAAVNSLSAAFDATL
                     LALGLGVTAAVVLVSLSRGRARPAVVDTLDTALMVPLGVSAVTVGFGYLITLDALPGDL
                     RTSSALVPLAQALVVTPLVIRMLLPVLRSIDQRLRQAAASLGASPWRVWREIDIPLAGR
                     SLLAAAAFGFVVALGEFGATSFLARPDTATLPVVIGRLISRPGELNNQMAYAACTLLMV
                     VTVAAVLLVERLRVQSVGEF"
     gene            8613..9620
                     /locus_tag="BN1701_RS30920"
     CDS             8613..9620
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012783372.1"
                     /locus_tag="BN1701_RS30920"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_054056276.1"
                     /transl_table=11
                     /translation="MMLRVEGVDVHYGALLAVSDVDIEVDDGEVVALLGPSGCGKSTLL
                     RAIAGLEPMSFGKVTWDDADLAGVPVHRRGFGLVFQDGQLFPHRDVAANVAFGLRMRGD
                     HEPGRVAELLELVGLAGCERRRVTELSGGEQQRVALARALAPRPRLLLLDEPLSALDRV
                     LREQLAMDLARVLRIEGSTAIVVTHDHDEAFTLADRVAVMRAGRIVQTGRPDQVWREPA
                     DEETARFLGCELVVDGEVDAGVLTCGFGIAAVPWAPEGPARVGLRPSALRVGEGPTEGT
                     VAARVHRRDHVRLLVDTPARQVNAVAGIADAPDVGDTVRLVLDPDGIAVLSRRG"
ORIGIN
        1 gccgtggtgt ccttcgtgga catcgcgggc atcgtcaagg gcgcgtcgga gggcgcgggc
       61 cttggcaaca agttcctcgc caacatccgc gaggccaacg cgatctgcca ggtcatccgc
      121 gtgttcgacg accccgacgt ggtccacgtc gacgggcggg tcgacccgat gtccgacatc
      181 gagacgatca acaccgagct catcctggcc gacctgcaga cgttggacaa ggccatcgtc
      241 cggctggaga aggaggcccg cacccgcaag gaggcgcgcc ccgccgccga ggccgcccag
      301 caggccaagg acatcctcga cgctggtcgg accctgttcg ccgcgcagaa agaggtcgac
      361 acctccctgc tgcgcgaact gagcctgctc acgaccaagc cgttcctgta cgtgttcaac
      421 gccgacgagg gcgtcctgct cgacgacgcc cgccgcgagg agctgaccaa actggtcgcc
      481 cccgccgacg cggtgttcct ggacgccaag gtcgaggccg aactgctgga gctggacgac
      541 gagtccactt tggaactgct ggagtcggtc ggccaggccg aaccgggcct caacgcgctg
      601 gccagggccg gtttccacac gctggggctg cagacgtatc tgacggctgg gccgaaggag
      661 gctcgcgcgt ggacgatccc gcagggggcc acggcgccgc aggccgcagg cgtgatccac
      721 tcggacttcg agcgcggttt catcaaggcc gaggtcgtgt cgttcgcgga cctggtggag
      781 acgggctcga tgaccgcggc gaaggcggcg gggaaggtcc ggatcgaggg caaggactac
      841 gtcatggccg atggcgacgt ggtcgagttc cgcttcaacg tctgaccgaa cagtccgatc
      901 cgacctcagt ggtgccagtt aagccccaga gtccggatga gatcgctcgc tagggcagcg
      961 aagctgggtg ccacggtggc gtctcccgcg gccgccaggg acgcgagctt ggggagatcg
     1021 aacctcggat cggtcccatg atcccggatg actctcaagc cgcgttcggt gaccggccgc
     1081 gcgtggtcgt cagcgacgtg tcgatgaatc ccgtcgacta gatcttcggt ctccacagct
     1141 tggagtagcc gaaacatatc gagtgcgtct ttttccttca ggcgggcttc ccttccgttc
     1201 gccgcgtccg cgagtcgttc ctcgatcttt atggctttcg cgatgagcaa agccgcgggt
     1261 ccggcgacct ggacgctgat cttcctgctg tctttctcat ccatggcgcc gatcatgtgc
     1321 caagatttgt cgaccaaagc tggttcgagg ccgcttgtga tgcgagatgt ttccctgtca
     1381 tgattcggga tccggcctgc gcgggcggtc ttgctggttg ttcctgcttg atgcggaaca
     1441 accatgatgt cgacggcaat atcgccgtcg gcgagccagg agccgggatt cctcccggcc
     1501 ttgaagccag ccgccctcat tgtcgcggag atctcggggc tgtcggccaa tcccgatgta
     1561 tccagggcaa ggtcggcgtc cgtcgtcatc ggaggctgcg cgagttggcc ttctcccgca
     1621 tgcatgtata cggcttgagc gccaacgagt acgatatttt ctagatgctt agagagagct
     1681 tctagggcgt tgagtaggac tgtgcgggcg gcaacatact caggggaatg ggtcatctac
     1741 tctctccagg cgagatcggt ttcggacaga aaatccatga gttgttcggc ctcttgtgcc
     1801 atgcgtcctg gcagagtcag tagatcggcg agtacctgcc ctagcggggc aacgaggccc
     1861 tgttccgaga gacgtgattg gtcgaggagg gagggttcgc gaaggggggc gatgatgacg
     1921 ttgcttgatt ctcggccgac acggacgagg cctagctctt tggcgagggt gcgaggatct
     1981 tgggcgtaca tggcgaggag ggtcagcggg atcaccgaga ttgatgtact tggcaagtag
     2041 gtgcgcgcgg cggccgagcc agtcatgcaa atatcgtctc gatcgcggac atgttcgatt
     2101 agtcgttgta agcctcgtgg ggcgacgtag tctaaggtca cgccattgga gttcaggaag
     2161 ctgtagtctt ttgtccagcg attgagcagt gctcggcgcc tgacccggac gatagttccg
     2221 tctgcgtcac ggtcgatcgc tccggccgcg atgagggcag gcatgagttt ggaaaccgcc
     2281 gcaggactgc tgaatgaaag ggctgcaagc tgccttatgc cgaccggtgg gtcgctatcg
     2341 agaagacggc ggatgatacg cccagccgcg ggtccgttca gtcgggcggt tgatttgttc
     2401 tcgcgttggt gtggcggttt ttcagctccg gtgagccgga taaggatcgg cggttcgtta
     2461 ctaacgatat atgtccaccc ggtggcgtcc aagtagttga tcccccgggc ttcgcaggcc
     2521 aaccggaggg gtgcgttaat atagtcggtg acgaataaca ggcggtgtgg actagctgcg
     2581 gccaaagcgc tcagatgtgt ggcggtttgc gtggaggaca tccgagttga cccggcctcg
     2641 atcatgaatg tgacttcgac gccagagtcg ttgccaatcc tgacggctgc gtcgctgggc
     2701 gtatcgggct tcggcatgat gagggttgcg taccagcggt cggggaggtt cgcacgcagg
     2761 gtcgccaatg caggcccgag gatactcgtt tcgtaaaggt gcccgtttcg tcgcatgtga
     2821 aacatgctag ttctcgaaac ggccatcgtc cagtcactcg ttgggctgac cggtacgggt
     2881 tggcgtcgcc ttcaagcctc cgagcgtctc gacatcgcgt tgaaggtcgc cgacctgctc
     2941 ggcgcccacg cgggccagtg atcttgctac cactttggta gcatcgctgt atggcgatga
     3001 cactgcggtt gaccgaggag caggagcgtg cgttggcgct gctcgcggag gctcaaggcg
     3061 tcagcaagca cgaagccgct gtccgcgcga tcaccgagtc cgccgctcgt agagttcgtg
     3121 acaagcgggt gtgtgcgttg tcgcgggagg gacgcgagcg ctacgcgtcg ctcctcgatc
     3181 gacttgccca gtgatcgtcg aatatctgac cctcgatgat ctgctgacgc tgacagtgga
     3241 tcttggagtc cccaacgttc gtgatctcgg tcttcttgac tcggccgcgc atcgcccaca
     3301 gtcctctttg atgggtcagg acgcctaccc cacactggac gagaaggcgg cggtgctgct
     3361 ggagtccatc gcgcgcaacc atccgctgat cgacgggaac aagcgtctgg cctggatggc
     3421 gacgtttgtt tgctacggcc tgaatggcgt cgatctggat gcgccggaag acgatgccta
     3481 cgacctcgtc atcggcgtgt ccacggggac tgtcgactat cggacggccg cgggcgtgct
     3541 gggcgggtgg gctcggcccg aggtcgcggc gccgaggggt tcgggcgaat tccgtctcga
     3601 cgggacggtc gaatagtcaa cccattcgtc aggtgaatca ttttcgtgat gggcgtccgg
     3661 tgagctgcgg cttgccgggc gttcgtgcgt cctacgccgt tcgtttgtct gactttcacc
     3721 cgacccccgt acggtgcgac acgcacggac accgtgtgaa cacgaactgt gacacgatcg
     3781 gagtcagacc gtggaacgtc gtaacttcct ccgggccgct gtgatcggcg gagctgccac
     3841 cgctttcggt ggcgccgcct gggcccccgc cttcgccgcc ccggctcagc ccggccctgg
     3901 cccgtatgga ccgctgcagg ccgcggacgc caacgggatc atgctcccct ccggattcac
     3961 cagtcgggtg atcgcccgat cgggacagct ggtcacgggc accagctacc cgtggcaccc
     4021 ggctccggac ggcggcgcgg tgttcgccga cggcaccggc tggatctatg tgtccaacag
     4081 cgaggtgtcc agcaccggcg gtgtcggcgc ggtcaagttc aactccagcg gcacgatcac
     4141 cggcgcctac cgcacgctgt cgaacaccaa cgtcaactgc gcgggcggcg cgacgccgtg
     4201 gaacacgtgg ctgtcgtgtg aggaggtgtc gctcgggcgg gtctacgaga ccgacccgtg
     4261 gggtgtcaac ccggccgtgt cgcgcccggc catgggtcgg ttcaagcacg aggcctgcgc
     4321 ggccgacgcc gaccacggct acatctacat gaccgaggac accagcgacg gctgtttcta
     4381 ccggttccgg ccgaccacct ggggcaacct gaccagcggc accctggagg tcatgaaggg
     4441 caccaactcc cagaccagcg gctcggtcac ctggggcgtc gtgcctgacc ccgacggcag
     4501 ccccaccgcc acccgcaacc aggtctccgg cgccaagcgg ttcaacggcg gcgagggctg
     4561 cgtgtacgcg gctgggacct gctggttcac caccaagggc gacaaccggg tgtgggcgta
     4621 cgacgcgaac acctcgacca tcgaactggc ctacgacgac tcgctcgtgg tcggcggcgg
     4681 cgctccgctg accggtgtcg acaacatcac ccgggcgggc agcggtgacc tgtacgtcgc
     4741 cgaggacggc ggcaacctgg agatctgcct catcacgccg gacgacatcg tcgcggtgtt
     4801 cctgcgggtg accgggcagt ccagctcgga gatcaccggc ccggcgttca ccccgaacgg
     4861 tcagcgcctg tacttctcgt cgcagcgtgg cacgtcgggc agcagcagcg gcggcatcac
     4921 ctatgaggtc accggtccgt tccggagctg agtgaaccag gcgcggcgcc cgtccggacg
     4981 ggcgccgcgc ctgactcgga ttacggcctg aacggcgcca gttcgccgtc cggtcccagc
     5041 gtgtccaccg cgttccgcgc ggtgtccttc agggtgggcg tgacgtcgta ggcgttgatg
     5101 acactgaggt agcccatgtc gccttcgagc ttgtcgacgc cgagctcgcg cccgttgatg
     5161 aagacggtgt agcggaccca gcccggctcg gactggcagc ggtcgatgat gtggatcgtc
     5221 ttgccctcgt accgctcggc gaagaacgac ggcgtgcagg tggccgtctg gggtgcggcc
     5281 atggcggccg ccggggtgag cgcgcaagcc gcaacggcca gcgcggcacc cgcgaggaga
     5341 gtgcgcatgg tgtgcctttc aggtgagtcg cagggaaggt gatcacctga ttccatatgt
     5401 accagacggt cggcgcccgc gcccgcgtca gcgtccgtcc ggcccccgca ccgtgtcgac
     5461 cacgccgtcg atctcctcgg ccatggtcac gtccaaggcg gtgacgccgc ccgcggagtg
     5521 ggtgctgcac cggaaggtca gggtgcgcca ccggatgtcg atgtcggggt ggtggttgtc
     5581 gttctccgcg atctcggcga tccggttgac gacctggatg gcctgcggga acccgtcgaa
     5641 ctcgacgacc cgcaccaggg cgccgtcctt gagcttccag tccggcagcg tgccgagcgc
     5701 gacgccgatg tccttgtcac tgagcagttc aggcatgacc ccaatactgg ccgctcggcc
     5761 aggcgtacgc tcgtcacgcc acgggagtcc gcctaggcgg gctgagagga ggggcgtgcc
     5821 ctcgaccgtc cgcacctgat ccgggtcatg ccggcgcagg aaggtcctcg tggtgcgtcc
     5881 acgccccgag gaggaacgat ccatgcgcaa gttcgtcgcc atcgcggccg cggttctcat
     5941 gaccgcgagc tgttcgttgt tcggctctga ggagtcgggc ggtgacggca aggtcgtcct
     6001 ggtcacccac gactcgttcg agttcgacca ggccgtgttc gacaagttca agaccgacac
     6061 cggcatcacc atcgaggtgc gcaagagcgg cgacgccggc gcgctgacca accagctggt
     6121 gctcaccaag tccagcccgc tcggcgacat cgccttcggg gtggacaaca ccttcgcctc
     6181 ccgcgcgctc accgagggtg tcttcgccga gtaccgcagc cccgaggccg acaagggtcc
     6241 gcagcggttc gccatcgacg acaccggcag gctgaccgcg gtcgacaccg gcgacgtgtg
     6301 cgtcaacgtc gacccggccg ggctcaccgc gcgcgggctt accgcgcccg ccacgttcga
     6361 ggaccttgcc gaccccaagt tcaaggacct gctggtcgtg gaggatccgg cgaccagttc
     6421 gccggggctg gcgttcctgc tggccaccgt ggcgcagtac ggccagaagg actgggtcgg
     6481 ctactggaac cggctcaagg ccaacggcgt gaaggtcgtg gcgggctggg aggaggccta
     6541 cacccaggag ttctccggct cgtccggcaa gggcccgcgg ccgctggtgg tctcgtacgc
     6601 gtcgtcgccg tcggctgagg tcgacgaggc gggcaaaccg cgcacggcgg cgctgctgga
     6661 cacctgcttc cgccaggtcg agtacgcggg cgtgctggcc ggggcgaaga acaccgacgg
     6721 cgcgcgcaag gtgctcgacc tgctgctctc ggagtccttc caggccaagg tgcccgagaa
     6781 gatgtatgtc tacccggccc gcgacggcgt ggcgctgccc gcggcgtggg cggccgcgcc
     6841 cgcgccgcag agcccggcga cgatggccgc cgccgacatc caggcgaacc gggagcggtg
     6901 gatcgagcag tggcgcacgg ccgtccgggg ctgagtccgc ggtcgacccg gcggcgggca
     6961 ccagcccgcc gccagtcgcg ggaggcgacc ggaccccgcg gcatcggcgc ggccgcccgc
     7021 cgtccacccc agggcacggg agcgctgctc gcggcgttgg tgccgttggg gttcctggcg
     7081 gtcttcttcc tgtggccggt ggccgcgatc gtccagcggg gtctgtcctc cggcggtgtc
     7141 ggccgggttc tggccgcggc cgacacctgg tcgctggtgc tgttcaccct ggcccaggcc
     7201 gcggcgtcga cgctggtcgc ggtcatcgcc gcgctgccgg tggcattcct gcttgcccgc
     7261 tgcgcgctgc cggggatggc ggtggtccgc gcggtgatcc tggtgccgtt cgtgctgccg
     7321 acagtggtgg tgggattggc tttccggtcg ctgctgccag acggcggcgt gctcgcgatc
     7381 gtgctggcga acgccttctt caacgtcgcc gtcgtcgccc gcaccgtgtc gggcctttgg
     7441 gcgcacctcg accgccgggc cgaggacgcg gcccggtcgc tgggcgcctc gccgctgcgg
     7501 gcgttcgtct cggtgaccct gcccgcgctg cggcctgcga tcggctcgtc ggcggcggtg
     7561 gtctttctct tctgtgccac cagtttcggt gtcgtcctgc tgctgggtgg ggcccgctac
     7621 cgaacgctgg agaccgagat ctacctgcgc acggtcgaat tgctcgatct gtccggtgcg
     7681 gcggcgctgt cgctgatcca ggtgaccgcc gtggtcgcgg tgctggtcct cgcggccgtg
     7741 gcgcggcggc gccgggagac ggcgatgacg ctacgcccgc gaaccgagac cgcccgtcgg
     7801 ccacggggcc gtgagtgggg ggtggtcgcg ggcgcctacg cggtggtggc ggccctgctg
     7861 gttcccattc tcgcgttggt cctgcgctca gtgtccactg aggatggttg gggcttggac
     7921 ggataccgcg cgttgtccgg caccgggttc cgcggttctc tgcaggtctc cggcatcgat
     7981 gccgctgtga attcgctgag cgccgcgttc gacgccacac tgctggcgct gggacttggc
     8041 gtcaccgcgg cggtcgtgct cgtgtcgctg agccgcggcc gggcgcggcc cgcggtggtc
     8101 gacacgctcg acaccgcgct gatggtgccg ctgggcgtgt cggcggtgac cgtcgggttc
     8161 ggctacctga tcacccttga cgccctgccc ggcgatctgc gcacgtcatc cgcgctggtg
     8221 ccgctggccc aggcgcttgt ggtgacaccg ctggtgatcc gcatgctgct cccggtgctg
     8281 cgctcgatcg accagcggct gcggcaggcc gccgcgtcgc tcggcgcgag cccgtggcgg
     8341 gtctggcgtg agatcgacat cccgctcgcg ggccggtccc tgctcgcggc ggcggcgttc
     8401 ggcttcgtgg tcgcccttgg cgagttcggc gcgacgagtt tcctggcccg ccccgacacc
     8461 gcgacactgc cggtggtgat cgggcgcctg atctcgcgtc caggggagtt gaacaaccag
     8521 atggcctacg cggcgtgcac gctgctgatg gtggtgaccg tcgcggcggt gctgctggtc
     8581 gaacgcctgc gggtccagtc ggtgggggaa ttctgatgct gcgggtcgag ggtgtggacg
     8641 tccactatgg agcactgctc gcggtgtccg atgtggacat cgaggtggac gacggtgaag
     8701 tggtcgcgct gttggggccc tcaggctgcg gcaagtccac gttgctgcgg gccatcgccg
     8761 ggctggagcc gatgtcgttc ggcaaggtca cctgggacga cgcggacctg gcaggcgtcc
     8821 cggtgcaccg gcgcggcttc ggcctggtct tccaggacgg ccagctgttc ccgcaccgcg
     8881 acgtggccgc caacgtcgcc ttcggcctgc gcatgcgggg tgatcacgag ccgggccgag
     8941 tcgccgagct gctggaactg gtcggcctgg caggctgcga acggcggcgg gtgaccgagt
     9001 tgtccggcgg cgagcagcag cgggtcgcgc tggccagggc gctggccccg cggccccggc
     9061 tgctgctgct cgatgagccg ctgtcggcgc tggaccgcgt actgcgcgag caattggcca
     9121 tggatctggc ccgagtgctg cggatcgagg ggagtaccgc gatcgtcgtc acccacgacc
     9181 acgacgaggc gttcaccctc gccgaccggg tcgcggtcat gcgcgcgggc cggatcgtcc
     9241 aaacaggacg gccggatcag gtgtggcgtg agcccgccga cgaggagacc gcgaggttcc
     9301 tcggctgcga gctggtcgtc gatggcgagg tcgacgcggg ggtcctgacc tgcgggttcg
     9361 gcatcgcggc cgtgccgtgg gcacccgagg ggcccgcccg cgtcgggctg cggccctcgg
     9421 cgctgcgggt gggggagggg ccgaccgagg gcaccgtcgc ggcccgcgtg caccgccgcg
     9481 accatgtgcg cctcctggtc gataccccgg cccgccaggt gaacgccgtc gccggaatcg
     9541 cggacgcgcc ggacgtgggg gacacggtcc ggcttgtcct cgaccccgac gggatcgccg
     9601 tgctcagccg tcgcggctga gcatccgcga cagcgccagg gagtagccga tcacgatata
     9661 gcagcccgcc cgcagcacgc cctccaacag ggtgccggtg ggcagcgggt cgcggatgac
     9721 ctccgggatg ctctcccagc tcgtggtcat caggaccggg tcgagccagt ccagcgccgg
     9781 gatcgcgctg agcacacccg acaggatgac cacgccgagg gacaccacga cgacgatcag
     9841 cgggtgctcg gtccacgccg acacggccag cgcgatcgcg gccagcgccc agacctgcac
     9901 cgtcaccagc agcacggtca gcaggatccg gccgagggcg tcgatgacgg gcagggaagt
     9961 gcccgacatg gtcagcatgc cgtcgccgcc gagcaggatc acgcccgcga tcgtgcctgt
    10021 gaccgccatc agcaggacta ccaggagcga gacggtggcc acgccgaacg ccttgacggc
    10081 gagtacgcgc gtcctgctta ccggggcgag cagtagtgat cggagtgtcc cgctggccgt
    10141 ttcgcctgcg agggcgtcgg cggcgagcat ggcgccggtc agggggagga gcatgttgag
    10201 ggcgaggatg agggcgaaga cggggagcag taggccgttg ccgtcgacga gcgcggcgat
    10261 gccgtcgcct actgggtcgc cgctttctcc gtctgcggcg atggctatgc cgatgcctgc
    10321 gatgacgggg actagggcca gtaggccg
//
