LOCUS       NZ_LN850107            10396 bp    DNA     linear   CON 13-AUG-2024
DEFINITION  Alloactinosynnema sp. L-07 isolate Alloactinosynnema sp. L-07
            chromosome I.
ACCESSION   NZ_LN850107
VERSION     NZ_LN850107.1
KEYWORDS    RefSeq.
SOURCE      Alloactinosynnema sp. L-07
  ORGANISM  Alloactinosynnema sp. L-07
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae.
REFERENCE   1
  AUTHORS   Ramaraj,Thiru.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAY-2015) National Center for Genome Resources (NCGR),
            National Center for Genome Resources (NCGR), 2935 Rodeo Park Drive
            East, Santa Fe, New Mexico, 87505, USA
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_900070365.1-RS_2024_08_13
            Annotation Date                   :: 08/13/2024 03:00:54
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,999
            CDSs (total)                      :: 6,934
            Genes (coding)                    :: 6,831
            CDSs (with protein)               :: 6,831
            Genes (RNA)                       :: 65
            rRNAs                             :: 3, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 3, 3, 3 (5S, 16S, 23S)
            tRNAs                             :: 53
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 103
            CDSs (without protein)            :: 103
            Pseudo Genes (ambiguous residues) :: 0 of 103
            Pseudo Genes (frameshifted)       :: 30 of 103
            Pseudo Genes (incomplete)         :: 83 of 103
            Pseudo Genes (internal stop)      :: 1 of 103
            Pseudo Genes (multiple problems)  :: 11 of 103
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 08:22:15
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 4725833
            Orig. end                         :: 4736229
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            LN850107.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..10396
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="melanin"
                     /region_number="28"
                     /rules="melC"
                     /tool="antismash"
     cand_cluster    1..10396
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="melC"
                     /kind="single"
                     /product="melanin"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10396
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:5396](+)"
                     /cutoff="20000"
                     /detection_rule="melC"
                     /neighbourhood="5000"
                     /product="melanin"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..5396
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="melC"
                     /neighbourhood="5000"
                     /product="melanin"
                     /protocluster_number="1"
     gene            complement(702..1016)
                     /locus_tag="BN1701_RS21015"
     CDS             complement(702..1016)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="BN1701_RS21015"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_157368136.1"
                     /transl_table=11
                     /translation="MAPHPRIQMDIETIERVGAHLTTIGRALGIDWTAFRQRIATGESG
                     IGTGVLGARYRVEYTPPADAIRRVADPLPGRFGDLGRAATLSAQSYSAGDKIAADQFPR
                     "
     gene            complement(1071..2159)
                     /locus_tag="BN1701_RS21020"
     CDS             complement(1071..2159)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015104508.1"
                     /locus_tag="BN1701_RS21020"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="MBL fold metallo-hydrolase"
                     /protein_id="WP_054051443.1"
                     /transl_table=11
                     /translation="MRRLLLALGLGLAAVAWIVRDIPAALGGKARGDRAARVQRSPQFR
                     DGAFHNRAHTAQIVPEAGRDMVRELMFGGQRRTPAGPVPLVSPAAPTDDGLFLTWYGHG
                     TTLVEIDGARVLFDPVWSERVSPSRLVGPRRLHPMPQPLSEVPDVDAVVISHDHYDHLD
                     LATVRALVETRTAPFVVPLGVGAHLERWQVPAERIIELDWEESTEIAGVRLTATAAQHF
                     SGRAFTRDDTLWASWVVAGPSRRVFYTGDSGYFDGYAEIGALHGPFDASLVQVGAYAPG
                     WPDIHMTPEEGVAAHVDLDGGLLIPVHWATFKLAMHGWSEPAERVWAESKARDVALAIP
                     RPGERIDVDNPPQVDPWWQTLA"
     gene            complement(2195..2665)
                     /locus_tag="BN1701_RS21025"
     CDS             complement(2195..2665)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="BN1701_RS21025"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_054051445.1"
                     /transl_table=11
                     /translation="MSQPCEESQPSDWGEIDELLRAVVADGFTVYLCGGPDVPEAIVAT
                     YAWENHVDYVVIKDAHDVTAARSRQSRDWDVFSADTVVWSYHGHARWALRAILDLLPPD
                     HPQAPDEEYPAPESLKVDEAHLRRVSVRTPRPGLVARRAMRLRTVTWGCRLA"
     gene            complement(2836..3300)
                     /locus_tag="BN1701_RS21030"
     CDS             complement(2836..3300)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1120: AsnC family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009948117.1"
                     /locus_tag="BN1701_RS21030"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="Lrp/AsnC family transcriptional regulator"
                     /protein_id="WP_054051447.1"
                     /transl_table=11
                     /translation="MGDLDAVDIAILRELQQDARLQNKELAAIVGVAPSTALERVRSLR
                     RRGVLTGFHATVNLAALGRPISALLSVRVRPHRQQIVAAFKAFVLDQPETVSLLHVAGP
                     DDYLIQVAVPDTTHLQQLLITRLLSRPEVVSVNTMLVFEAIGQPVQGPIG"
     gene            complement(3321..4472)
                     /locus_tag="BN1701_RS21035"
     CDS             complement(3321..4472)
                     /NRPS_PKS="Domain: Aminotran_1_2 (69-235). E-value:
                     3.8e-08. Score: 24.8. Matches aSDomain:
                     nrpspksdomains_BN1701_RS21035_Aminotran_1_2.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_1_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1168: O-succinylhomoserine sulfhydrylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020640947.1"
                     /locus_tag="BN1701_RS21035"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="PLP-dependent aspartate aminotransferase family
                     protein"
                     /protein_id="WP_054051449.1"
                     /sec_met_domain="Aminotran_1_2 (E-value: 4.5e-06, bitscore:
                     24.7, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSRLATLAVHAGRDDLAGLGVHVPPIDLSTTNPVPSVESGGAAYE
                     ALATGGLPPAEGGLVYQRLWNPTVARFEDALAALERAEQAVAFGSGMAALTACLIATVS
                     AGKPHIVAVRPLYGGSDHLLATGMLGTEVSWVEPDGVAAAIKDTTGLVIVETPANPTLD
                     LLDLRAVTAAAGDVPVLVDNTFATPVLQRPVEHGATLVLHSATKYLGGHGDVIGGVVAA
                     DAEWATRLRGVRAITGGLMHPLAAYLLHRGLQTLPVRVQQQQTNAIAIADWLGGQQHVE
                     RVYFPSGELVGRQMSGPGAMVAFAVDGGYAAAARTVEAVRLITHAVSLGGVDSLIQHPA
                     SLTHRPVAAHAKPNAAVLRLSVGLEHVDDLVADLEYALKEAHR"
     aSDomain        complement(3768..4265)
                     /aSDomain="Aminotran_1_2"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_BN1701_RS21035_Aminotran_1_2.1"
                     /evalue="3.80E-08"
                     /label="BN1701_RS21035_Aminotran_1_2.1"
                     /locus_tag="BN1701_RS21035"
                     /protein_end="235"
                     /protein_start="69"
                     /score="24.8"
                     /tool="antismash"
                     /translation="ARFEDALAALERAEQAVAFGSGMAALTACLIATVSAGKPHIVAVR
                     PLYGGSDHLLATGMLGTEVSWVEPDGVAAAIKDTTGLVIVETPANPTLDLLDLRAVTAA
                     AGDVPVLVDNTFATPVLQRPVEHGATLVLHSATKYLGGHGDVIGGVVAADAEWATRLRG
                     VRA"
     misc_feature    4534..4549
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 20.81"
                     /tool="antismash"
     gene            5001..5396
                     /locus_tag="BN1701_RS21040"
     CDS             5001..5396
                     /GO_function="GO:0005507 - copper ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0042438 - melanin biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     melanin: melC"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF017995.4"
                     /locus_tag="BN1701_RS21040"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="tyrosinase family oxidase copper chaperone"
                     /protein_id="WP_197672129.1"
                     /sec_met_domain="melC (E-value: 6.8e-33, bitscore: 112.4,
                     seeds: 38, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNNGEMPGTSRRRFLTGAFATGALAVVGASGALIATSANSATATV
                     IHEKFDEVYKGRRIAGTHASDKLTSTKYIDALTVDGDAVHVMRNGNGTLVTSVNHYEPF
                     ATLREAARAAVDTLGDARPLPVGHGHH"
     misc_feature    complement(5413..5428)
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: medium, score: 23.66"
                     /tool="antismash"
     gene            5427..6254
                     /locus_tag="BN1701_RS21045"
     CDS             5427..6254
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015101895.1"
                     /locus_tag="BN1701_RS21045"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="tyrosinase family protein"
                     /protein_id="WP_054051453.1"
                     /transl_table=11
                     /translation="MGIRKNQANLTATERTNLVNALLAMKANGQYDVFVQQHIDRSNGD
                     SDNGVRIGHRAPSFLPWHRRFLLDFENALKAINPAVDLPYWDWTTAGSTSTLWSTSFMG
                     PNGSSTQNWRVTSGPFAQSSGNWTLNVRTDSNNYLRRRFGAGTGTVLPTAAQVSTVLGL
                     TNYDTSPWNSTSLTSFRNQLEGWNGPNLHNRVHVWVSGTMAGFGSPNDPVFWMHHCNID
                     RLWSQWQAANPTRTYIPTSGTTNVVDIDEPMLPWGGSVTPRSMLSHSASYTYA"
     gene            complement(6420..7037)
                     /locus_tag="BN1701_RS21050"
     CDS             complement(6420..7037)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF012655.4"
                     /locus_tag="BN1701_RS21050"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_054051455.1"
                     /transl_table=11
                     /translation="MSAPDTPYQVRRTPTQFRATRQIERILDAAARVVVDKGFSAATTA
                     DIAKTAKVSIGSVYRYFPDKLAVMRAVVERNTLRYQDRVTAEAAVLPVWHEAVARAYSI
                     YVGMCRTDEGFRAISNAGLAAGELDSNEFDDPLADGLADVLVDRFGFIDTAELRVTLLQ
                     AVTIGDVLTRLAFRLDPTGHEDTLAKTAAMVHELIAVHAPSR"
     gene            7142..7558
                     /locus_tag="BN1701_RS21055"
     CDS             7142..7558
                     /EC_number="2.1.1.-"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018686418.1"
                     /locus_tag="BN1701_RS21055"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="HIT family protein"
                     /protein_id="WP_054051457.1"
                     /transl_table=11
                     /translation="MTPKPCIFCQIADGELPAAVVHEDDATIAFLDHRPLFHGHTLVVP
                     KTHVQVLSDLPAERVPAFFTLAQRLERAVEDGLGADGSMILINNVVSQSVPHLHLHVIP
                     RRRKDGLRFWLGPRHPYDAENRAEDFAARIRSAL"
     gene            7844..8731
                     /locus_tag="BN1701_RS21060"
     CDS             7844..8731
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="BN1701_RS21060"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_157368137.1"
                     /transl_table=11
                     /translation="METSARWRAPVLVMGAALLLPLMLTFAFNLPRWLTVVLLVLSIGA
                     GAMGIRQVVFQREQAELRAEAAKERAAAKPEPEPTLNEHHVPAIPIDSAEPYYRFVLSC
                     KVCWTTHPDADHGNPRGLAVHAVLERARQITVTGAPTDSDNVRTRLAAELGVKVVDRSG
                     QITAWAEDVGLTIPETDVARLARLAELRKEKQVLHQERELEQSTRSYLTENVFTDPGSA
                     MVWWLSRHPDQIREAAALLPTFAELTAAVNDTEVSPKYAQAERPTLSAVANGEWNRLAG
                     DEDRRQLPRTSDPD"
     gene            complement(9089..10051)
                     /locus_tag="BN1701_RS21065"
     CDS             complement(9089..10051)
                     /EC_number="3.5.1.2"
                     /GO_function="GO:0004359 - glutaminase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006541 - glutamine metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009943877.1"
                     /locus_tag="BN1701_RS21065"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="glutaminase"
                     /protein_id="WP_369800580.1"
                     /transl_table=11
                     /translation="MGYPGGEATAVLERSSRPFLRTALDDVRAAVEPMIGTGRVADYIP
                     ALSTVDPKRFGMAVATVDGETYGIGDYRQPFSVQSLAKVFAFALTLAVDGDGVWGRLGR
                     EASPHPFNSLVQLEQDLGVPRNPFLNAGALVTTDRLLTLTGDAAGALRAFLCAESGNTS
                     VDTDPEVASSELAHVHRNAALAHLVASYGNLDNAVADVLDHYVRQCAISMSCEDLAAAA
                     LFLARGGLGADGAAILDRDATKRLNATMLVCGMYGGAGEFAYRVGLPAKSGVGGGIIAV
                     VPNRCVVCVWSPGLDACGNSVAGVAALEAFSSITGWSVF"
     misc_feature    complement(9992..9994)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
ORIGIN
        1 gagaatgcgc gacttgtgat cccatgggcc gccggtcttc accaagtcgt accactcctt
       61 gagtccgcgc gctttgtcca gcggattgct cgactccagc agccgccgaa ttctctcgac
      121 ctcggcggag ttcccgttct tgttcatctc gttcaggatg aacacgctga tattgttgca
      181 ttcggcgaac ggactctgat cgccggtatt gttctgaacc gtcacgccgg agtcgaggta
      241 ttcgacagcg gtcgccgcgt cacgaatgat ccggttgact atcgccgcgg tcgcctggac
      301 gaatcggcgc cgcgcgagca cgggcagcac cacgatgccg gtgagcagtc cgtaggccgg
      361 gatggcggcc atgatcgtgt ggttgatctt gagcttggtg ttcgcgacga tcgtggcgaa
      421 cgccttggcg tggttgctct gctgatggca gctcagcccc accctggccg cgtcgttgtt
      481 ggccaccgcc aaggctccgg cgaatccgac gcccgcggcg tcggtccagg cggctcgcgt
      541 ctcgcgggtg tcgtagaccg cggcgttgaa cgagtcgccc gcgccgcgcc atgtcctggc
      601 cagttcgcgc acggtgtcct cattggtgtc cggccagccg gtcttcgcct tgaccgccga
      661 ccacagcccg aaggtgtctg gtggttccgg gaccatgacg cctaccgcgg gaattggtcg
      721 gccgcgattt tgtcgcccgc cgaatacgac tgggcggaca gtgtcgccgc gcgaccgaga
      781 tcgccgaatc ggccgggcag cggatcggct acccggcgga tcgcgtcggc gggcggggtg
      841 tattccaccc gataccgcgc gccgagaaca ccggtgccga ttccggattc gccggtcgct
      901 atccgctgcc gaaacgcggt ccagtcgatt cccagcgcgc gcccgatcgt cgtgaggtgt
      961 gcgccgactc gttcgatcgt ctcgatgtcc atctggatgc gagggtgcgg tgccatgaga
     1021 cgagtctcgg ccccgcctga ggcgacggga gcgagccggc cggttccggc ctacgccagg
     1081 gtctgccacc acgggtcgac ctgcggcggg ttgtccacgt cgatccgctc gccgggccgc
     1141 gggatcgcga gggcgacgtc gcgggccttc gactcggccc agacccgctc ggcgggctcg
     1201 gaccagccgt gcatggccag cttgaacgtg gcccagtgca ccgggatcag caggccgccg
     1261 tcaaggtcga cgtgcgcggc gacgccctcc tccggggtca tgtggatgtc gggccagccc
     1321 ggggcgtacg cgccgacctg gaccagggac gcgtcgaacg ggccgtgcag cgcgccgatc
     1381 tcggcgtagc cgtcgaagta gccggagtca ccggtgtaga agacccggcg ggacgggccc
     1441 gccacgaccc aggacgccca cagcgtgtcg tcgcgggtga aggcgcggcc ggagaagtgc
     1501 tgggccgcgg tcgcggtgag ccggacgccc gcgatctccg tgctctcctc ccagtccagc
     1561 tcgatgatcc gctcggccgg gacctgccac cgctccaggt gcgcgccgac cccgagcggc
     1621 accacgaacg gcgcggtcct ggtctcgacc agcgcgcgca cggtggccag gtcgaggtgg
     1681 tcgtagtggt cgtgcgagat gacgacggcg tcgacgtcgg ggacctccga cagcggctgc
     1741 ggcatcgggt gcagcctgcg cgggccgacc agccgcgacg gcgacacgcg ctcgctccac
     1801 actggatcga acagcacgcg cgcgccgtcg atctcaacca gggtggttcc gtggccgtac
     1861 caggtcagga agaggccgtc gtcggtcggg gcagcggggc tgaccagcgg gaccggcccg
     1921 gcgggagtgc gccgctgacc gccgaacatc agctcgcgca ccatgtcgcg gcccgcttcg
     1981 gggacgatct gcgcggtgtg ggcgcggttg tggaaggcgc cgtcgcggaa ctgcggcgag
     2041 cgctggaccc gggccgcgcg gtcgccgcgc gccttgccgc ccagcgcggc cgggatgtcg
     2101 cgcacgatcc acgcgaccgc cgcgagtccc agtcccaaag ccagaagaag ccgtctcatc
     2161 ccacgatggt gccatcgaaa agctgtgacc gtcctcaggc gagtcggcaa ccccacgtca
     2221 cggtgcgaag ccgcatcgcg cggcgggcga ccagacccgg gcgcggcgta cggaccgaca
     2281 cccggcgcaa gtgggcctca tcgaccttga ggctctccgg cgccgggtac tcctcgtccg
     2341 gtgcttgcgg gtggtccggc gggagcaggt cgaggatcgc gcgcagggcc cacctggcgt
     2401 gcccgtggta ggaccagacg acagtgtcag cggagaagac gtcccaatcg cggctctgcc
     2461 gggaccgggc ggcggtgacg tcgtgcgcgt ccttgatcac cacatagtcg acgtggttct
     2521 cccacgcgta ggtcgccacg atcgcttccg ggacgtccgg gccgccgcag aggtacacgg
     2581 tgaagccgtc ggccacgacc gcgcgcagga gctcgtctat ctcgccccag tcggacggtt
     2641 gtgactcttc gcaaggttga ctcatcgtca tcacccgaat ggccggtgcc gccgccgccg
     2701 agtgcccccg agcgatgaca cggtgtgtcc gtctcaccct gtttaccgca cccggacgac
     2761 acgtagctac ccattcatgc caccgacacc aatgtgtcat tcacagtttg atgtcacccg
     2821 tgtgagtgac gactcctacc cgatcggccc ttgcaccggt tggcctatcg cctcgaacac
     2881 cagcatggtg ttgaccgaga cgacctccgg gcgactcaac aggcgggtga tgagcagctg
     2941 ctgcaggtgc gtggtgtcgg gcacggcgac ctggatgagg tagtcgtcgg gccccgccac
     3001 atgcagcaac gacaccgtct cgggctggtc gaggacgaac gccttgaacg cggccacgat
     3061 ctgctggcgg tgcggccgga cgcgcaccga gagcagcgcg ctgatcggcc tgccgagcgc
     3121 ggccaggttc acagtcgcgt ggaatcctgt gaggacaccg cggcggcgca gcgaccgcac
     3181 ccgctccagc gcggtggacg gcgcgacccc gacgatcgcg gccagttcct tgttctgcaa
     3241 ccgcgcgtcc tgttgcaact cgcgcaggat cgcgatgtcg acggcgtcga gatcacccat
     3301 cgaccgactg tactgtccgg tcagcggtgt gcctccttga gcgcgtactc caggtccgcg
     3361 accaggtcgt cgacgtgctc gagcccgacc gacagccgca gcaccgccgc gttcggcttc
     3421 gcgtgcgccg cgaccggccg gtgggtcagc gaggccgggt gctggatcag cgagtcgacc
     3481 ccgccgagcg agacggcgtg ggtgatcagc cgcaccgcct ccaccgtccg cgccgccgcc
     3541 gcgtacccgc cgtcgacggc gaaggcgacc atcgcgcccg gcccggacat ctgcctgccg
     3601 accagctcgc cggacggaaa gtacacccgc tcgacgtgct gctgaccgcc gagccaatcc
     3661 gcgatcgcga tggcgttggt ctgctgctgc tgaacccgca cgggcagcgt ctgcaaaccg
     3721 cggtgcagca ggtaggcggc cagcgggtgc atcaatcccc cggtgatggc ccgcacgccg
     3781 cgcagcctcg tcgcccactc cgcgtcggcg gccacgacgc cgccgatgac gtcaccgtgc
     3841 cccccgaggt acttggtcgc cgagtggagc acgagggtcg ccccatgctc caccggccgc
     3901 tggagaaccg gcgtggcgaa ggtgttgtcc accagcaccg gcacgtcacc cgccgcggcg
     3961 gtgaccgcgc gcaggtcgag caggtcgagg gtcgggttcg cgggggtctc cacgatcacc
     4021 agcccagtcg tgtccttgat cgccgccgcc acgccatccg gctcgaccca gctgacctcg
     4081 gtgccgagca tcccggtggc cagcaggtga tccgacccgc cgtagagcgg ccgcacggcc
     4141 acgatgtgcg gcttgcccgc gctgaccgtc gcgatgagac acgcggtcag cgcggccatc
     4201 ccggatccga acgcgaccgc ctgctcggca cgttcgaggg ccgccagagc gtcctcgaac
     4261 cgcgcgaccg tggggttcca cagtcgctgg tagaccagcc caccctccgc gggcggcagt
     4321 cccccggtgg cgagggcctc gtaggccgcc ccgccggact cgacgctggg caccgggttg
     4381 gtggtggaca gatcgatcgg gggcacatgc acgccgagtc ccgcgagatc atcgcggccc
     4441 gcgtgcacgg cgagagtggc caggcggctc atcggcgctc ctctgtgtcg ggtccacaga
     4501 ggatcgcccg gttcggcggg ctaccggcgg gtcacgaaat ccggttcgat tacgaccccg
     4561 cacggcacgt ccgaccgaat cggattcggc tcgggacgtc gcggcgggaa ggaaccggga
     4621 ctgccgccgt cagcccacgt cctccccggg gggcttcctt ggccaggtgg cgggccgttc
     4681 ccggcaatgc ggtgctgccc gtcgggtggc cgtcgacggc gtcgcggtcc atcgcgtatc
     4741 agcctgaccc cgcggcgctg cctttgcgaa tgcgccatca cgaattgcca taacatcgcg
     4801 gagttctgag taccacgtaa tccgccgccc tccttaaagc agcgcgcgcg gtgactcggc
     4861 gaccgaggtc acagtccatt gtcggcaccg gccaattcac agaatccttg tctcgtccgg
     4921 cgctgcgtcg ccggaccacc ccggccacgc cctttccggc gcggaccggc ctgcccattt
     4981 atcgaggagt tcgacaattc atgaacaacg gggaaatgcc gggtacgtcc cggcgtagat
     5041 tcctgaccgg ggcgttcgcc acgggggccc ttgcggtcgt gggcgcaagc ggcgcgctga
     5101 tcgccaccag cgcgaactcg gccaccgcca ccgtgatcca cgagaagttc gatgaggtct
     5161 acaagggccg ccgcatcgcg ggaacgcatg ccagcgacaa gctgaccagc acgaagtaca
     5221 tcgacgcact caccgtcgac ggggacgccg tccacgtgat gcgcaatggc aacggcacgt
     5281 tggtgacctc ggtcaaccac tacgagccct tcgccacgct gcgcgaagcc gccagggccg
     5341 cggtggacac cctgggcgac gctcggccgc tcccggtcgg ccacggccac cactgacctc
     5401 gacaactttc gtagtggagt agaccaatgg gaattcgcaa gaaccaggcg aatctgaccg
     5461 ccaccgaacg aacgaacctc gtcaacgcgc tgctcgccat gaaagcaaac ggccagtatg
     5521 acgttttcgt gcagcagcac atcgacagat cgaacggcga cagcgacaac ggcgtgcgaa
     5581 tcggccaccg ggcgccgagc ttcctgccgt ggcaccgccg attcctgctc gacttcgaga
     5641 acgcgctcaa ggccatcaac cccgctgtcg acctgcccta ctgggactgg acgacggccg
     5701 ggtcgacctc gacgctgtgg tcgacgagct tcatgggccc caacggctcc tcgacgcaga
     5761 actggcgcgt cacgtcgggc ccgttcgcgc agagcagcgg gaactggacc ctcaacgtcc
     5821 gcacggacag caacaactac ctgcgccgcc gcttcggcgc gggcaccggc actgtcctgc
     5881 cgaccgccgc gcaggtcagc acggtcctcg ggctgaccaa ctacgacacg tcgccgtgga
     5941 acagcacgtc gctgacgagc ttccgcaacc agctcgaagg ctggaacggg cccaacctgc
     6001 acaaccgggt gcacgtgtgg gtctcgggca cgatggcggg gttcggctcg cccaacgacc
     6061 cggtcttctg gatgcaccac tgcaacatcg accggctgtg gtcgcagtgg caggccgcga
     6121 acccgacgcg cacctacatt ccgacctctg gcaccaccaa cgtggtcgac atcgatgagc
     6181 cgatgctgcc ctggggcggt tcggtgacgc cgcggagcat gctgtcgcac tcggcttcgt
     6241 acacctacgc gtagcccacg tttcgcctgt cgtgaatcgg ggttcgctcc ttcgggggcg
     6301 aaccccgtca cagcccgaac atgatcgggt acgcggcgca ggctatggcg gtgatcacct
     6361 tgctaccagc gggtttccca actgactttg tggacggtcg gccgcggaca ccccaacggt
     6421 cagcggctcg gggcgtggac cgcgatcagc tcgtggacca tggcggcggt cttcgccagc
     6481 gtgtcctcgt ggccggtcgg gtcgagccgg aacgccagcc gggtgagcac gtccccgatc
     6541 gtcaccgcct ggagcagggt cacccgaagc tcggcggtgt cgatgaagcc gaagcggtcg
     6601 accagcacgt cggccaggcc gtcggcgagc gggtcgtcga actcgttgga gtcgagttcg
     6661 cccgcggcga ggcccgcgtt gctgatggcc cggaagccct cgtcggtgcg gcacatcccg
     6721 acatagatcg agtacgcgcg ggcgacggcc tcgtgccaga ccggcagcac ggcggcctcg
     6781 gcggtgacgc gatcctggta gcgcagggtg ttgcgttcca cgacggcgcg catgacggcg
     6841 agtttgtcgg ggaagtagcg gtagaccgag ccgatggaca ccttggcggt cttggcgatg
     6901 tccgctgtcg tcgcggccga gaagcccttg tccaccacga cccgggcggc ggcgtcgagg
     6961 atgcgttcga tctgccgggt ggcgcggaac tgggtcgggg tccgacgcac ctgatacggg
     7021 gtgtctgggg cgctcattgc gccattgtgc ccagcacaca tgaccggtcg tcgaccggct
     7081 gtgccgatct tgacagcgac accgcgcccg cggatatccc agtgagccat aacatgcacc
     7141 gatgaccccc aagccgtgca tcttctgtca gatcgccgac ggcgagctgc ccgccgccgt
     7201 ggtccacgag gacgacgcga cgatcgcctt cctcgaccac cggccgctgt tccacggcca
     7261 cacgctcgtg gtgcccaaga cgcacgtcca ggtactcagc gacctgcctg ccgagcgggt
     7321 cccggccttc ttcaccctcg cgcagcggct ggagcgggcg gtggaggacg ggctgggcgc
     7381 ggacgggtcg atgatcctga tcaacaacgt ggtcagccag tcggtgccgc accttcacct
     7441 gcacgtcatc ccccgtcgac gcaaggacgg cctacgattc tggctcggcc cgcgccaccc
     7501 gtacgacgcg gagaaccggg ccgaggactt cgccgcgcgc atccgttcgg cgctctagcg
     7561 ctgtgtccat gagcgttgtc gggctatcgg cggatccagg tttccgctgg gcgtgccgcc
     7621 ggaatgccgc tcgtactggg tgtacttggg ctttccggcg gtgcgcccag cgggaagctg
     7681 ggccgtcgag agcctggcaa cgttcgtgga cacagcgcta agccccctga tgccggatcg
     7741 gttcagccgc ttggcccaag cccgccgtga tgatgttcgt atgttcgagg gaatccgaat
     7801 ggatcggcta ctgcgacaag gtcccaccag gtacgcacac agtgtggaga cctccgcgcg
     7861 ctggcgggcg cccgtcctgg tgatgggcgc cgcgttgctg ttgccgctca tgttgacctt
     7921 cgccttcaac ctcccgcggt ggctcaccgt ggtcctgctc gtgctgtcca tcggcgcggg
     7981 cgcgatgggc atccggcagg tggtgttcca acgcgaacag gccgagctgc gggccgaggc
     8041 ggccaaggag cgggccgcgg ccaagcccga gccggagccc acgctgaacg agcaccacgt
     8101 ccccgccatc ccgatcgaca gcgccgagcc gtattaccgg ttcgtcctgt cctgcaaggt
     8161 ctgctggacg acgcatccgg acgccgacca cggcaatcct cgcggtttgg ctgttcacgc
     8221 cgtcctggaa cgggcccgcc agatcacggt gaccggggcg ccgaccgact cggacaacgt
     8281 gcgcactcgc ctcgccgcgg agttgggtgt gaaggtggtg gaccggtccg ggcagatcac
     8341 ggcttgggcg gaggatgtgg ggttgacgat tccggagacg gacgtcgctc ggctggctcg
     8401 gctcgcggag ctgcgcaagg agaagcaggt gctgcaccag gagcgggagc tggagcagag
     8461 cactcggtcg tatttgacgg agaacgtctt cactgatccg gggagtgcga tggtgtggtg
     8521 gctgtcgcgg catcctgatc agattcggga ggccgcggcg ttgttgccga cgtttgcgga
     8581 gttgacggcg gcggtgaatg acactgaggt ttcgccgaag tatgcgcagg ctgagcggcc
     8641 gacgttgagt gcggtggcca atggggagtg gaatcggttg gctggggacg aggatcggcg
     8701 gcagttgcct cggaccagcg atcctgactg agcctgctcg cctgcttggc tggtggggct
     8761 gatgggctgg tgggcgccgt cttgcttggc cccttgcgtt ccgttgtggt gatgcactgc
     8821 aaccactatg acttccaccc ctgtaacgga ttggtggggt gaccccgggg cgactgattg
     8881 gcagcgccgc cccggggtca cctggcctcg ccgtgcgagg gcgcgtcaat ccggtgtccc
     8941 ggccggatta gtgcgttgcg gcgaggccgg acggccgacc gtagtcgacc ctgctcgact
     9001 ccgtggccgt ccaggatcat gttggcggta tcgggggcgc gtgacaacac cactacgggt
     9061 gtaaaccacc gttgaacgca aatttttctc agaacacgga ccagccggtg atcgacgaga
     9121 aggcctccag ggccgccaca cccgccaccg agttgccgca ggcgtccagg ccggggctcc
     9181 agacgcacac gacgcatcgg ttggggacca ccgcgatgat gccgccgccg acgccgctct
     9241 tggcggggag gccgacgcgg taggcgaact cgcccgcgcc gccgtacatc ccgcagacca
     9301 gcatggtggc gttgaggcgt ttggtggcgt cgcggtcgag gatggcggct ccgtcggcgc
     9361 cgaggccgcc tcgggccagg aagagggccg ccgcggcgag gtcttcgcag gacatcgaga
     9421 tggcgcactg gcgcacgtag tggtcgagga cgtcggcgac ggcgttgtcc aggttgccgt
     9481 agctggccac caggtgcgcg agcgcggcgt ttcggtggac gtgggccagt tcggaggagg
     9541 cgacctcggg atcggtgtcg accgaggtgt tgcccgactc cgcgcaaaga aaggcgcgca
     9601 atgcgcccgc ggcgtcgccg gtgagggtga ggaggcggtc ggtggtcacc agggcgcccg
     9661 cattgaggaa tgggttgcgg gggacgccca ggtcctgttc gagctgcacc agggagttga
     9721 acgggtgggg cgaggcctcg cgcccgagtc ggccccagac gccgtcgccg tcgacagcca
     9781 gggtcagcgc gaaggcgaag acctttgcca ggctctgcac cgagaacggc tgccggtagt
     9841 cgccgatgcc gtaggtctcc ccgtcgacgg tggccaccgc catgccgaac cgtttggggt
     9901 ccacagtgga caaggcgggg atgtagtcgg cgacccggcc ggtgccgatc atcggctcca
     9961 cggcggcgcg cacgtcgtcc agtgccgtac gtaagaacgg tctcgacgat ctttcgagga
    10021 ccgcggtcgc ctcgcctccg ggataaccca ccgctgcaga atgaccccct acctcggcta
    10081 cgcacaacga gggcgcgggc ttaactgtta actccactac gaccagcgga aaccgtggca
    10141 accaggaccg aagttgagcg cgacggaatg cacgctcccg ctggcgtcgg aaacagcgga
    10201 aacggtctgc tcggggccac cgccgacccg gctgtagcgc tcgatgcgcg acggcagcgc
    10261 gcgcgggtcg aaggtcacct ccagcacgaa ctcccgcacc gggaaccgga acttccgctc
    10321 atagttgcga tccaccggaa acggcgcggc gtgcacgatc tcgtgctcgg tgatcaccgt
    10381 ctcgcccctg gccagc
//
