LOCUS       NZ_LN850107            25308 bp    DNA     linear   CON 13-AUG-2024
DEFINITION  Alloactinosynnema sp. L-07 isolate Alloactinosynnema sp. L-07
            chromosome I.
ACCESSION   NZ_LN850107
VERSION     NZ_LN850107.1
KEYWORDS    RefSeq.
SOURCE      Alloactinosynnema sp. L-07
  ORGANISM  Alloactinosynnema sp. L-07
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae.
REFERENCE   1
  AUTHORS   Ramaraj,Thiru.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAY-2015) National Center for Genome Resources (NCGR),
            National Center for Genome Resources (NCGR), 2935 Rodeo Park Drive
            East, Santa Fe, New Mexico, 87505, USA
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_900070365.1-RS_2024_08_13
            Annotation Date                   :: 08/13/2024 03:00:54
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,999
            CDSs (total)                      :: 6,934
            Genes (coding)                    :: 6,831
            CDSs (with protein)               :: 6,831
            Genes (RNA)                       :: 65
            rRNAs                             :: 3, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 3, 3, 3 (5S, 16S, 23S)
            tRNAs                             :: 53
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 103
            CDSs (without protein)            :: 103
            Pseudo Genes (ambiguous residues) :: 0 of 103
            Pseudo Genes (frameshifted)       :: 30 of 103
            Pseudo Genes (incomplete)         :: 83 of 103
            Pseudo Genes (internal stop)      :: 1 of 103
            Pseudo Genes (multiple problems)  :: 11 of 103
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 08:22:15
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 4466131
            Orig. end                         :: 4491439
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            LN850107.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..25308
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="25"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..25308
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..25308
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:15308](-)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..15308)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     gene            complement(110..1009)
                     /locus_tag="BN1701_RS20010"
     CDS             complement(110..1009)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024056.4"
                     /locus_tag="BN1701_RS20010"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="conjugal transfer protein"
                     /protein_id="WP_054051097.1"
                     /transl_table=11
                     /translation="MQSPPRDGWFVRGRRAAILSAAVAVMLVGAASMIDSVRTWLRPDP
                     IAERQVDPVGFAGTATVAATDYFAWDQEDKPSRTTALDRIAEPGADIDGWNGAGKQRVD
                     GVAVLDVNRFARELAVVTVQVHVIPFTKPAAPSQPGGLKASWTALPARWLTAAIPVRSL
                     PGGRFALSGRPALVGQGHSADLGNDAATEPPDADFSADTTVVVSKLLTAYGTGDLEFVR
                     AAGAGFLGLDGAAELAELDEWRVAPKADNSGVRIGTATVRWRLPGDATLACTYRIAISD
                     RDGIWLLSAITVDAGGPR"
     misc_feature    complement(1253..1266)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 18.84"
                     /tool="antismash"
     gene            1590..2006
                     /locus_tag="BN1701_RS20015"
     CDS             1590..2006
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024949.4"
                     /locus_tag="BN1701_RS20015"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_054051099.1"
                     /transl_table=11
                     /translation="MAKANSSPGMLAERLRTLRESVRPSPTARYSYAAIAAGCQDYLQD
                     PYPPSREYISSLFNGKADNPTRRMLEALADFFDVSPAYFFDDAASVAIQQDLELYAVLA
                     EKGISRVQLRALANLDEDGIQAVRELLTKLPTTD"
     misc_feature    2222..2236
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 16.84"
                     /tool="antismash"
     gene            2288..2911
                     /locus_tag="BN1701_RS20020"
     CDS             2288..2911
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="BN1701_RS20020"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_054051101.1"
                     /transl_table=11
                     /translation="MISVEVLAIPEPGRCGWQLLPAQTAVPRWLAARIDWYVRPSAART
                     AAASIGRVLCEHVDWESVWARDRGLFLRREHLGAPPPPVFFHAAATLAALGSTLLLEVE
                     LEMVADKLALAVYGTGVRGAMTSEAWRSVAGLLTTCASTVREPWPRQLPVRPHVSPAAW
                     VHDDHYTWWSYPFAGPVRESCGCAAEHGQPGAGFGPKPGGHRRG"
     gene            3087..3599
                     /locus_tag="BN1701_RS35780"
     CDS             3087..3599
                     /EC_number="2.-.-.-"
                     /GO_function="GO:0042834 - peptidoglycan binding [Evidence
                     IEA]"
                     /GO_function="GO:0071972 - peptidoglycan L,D-transpeptidase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF015679.4"
                     /locus_tag="BN1701_RS35780"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="L,D-transpeptidase"
                     /protein_id="WP_172803285.1"
                     /transl_table=11
                     /translation="MADLPTYAYGLLRTWVPIIDARPGWALVLLPCLPDGSVGWVRLDD
                     RVVIVAQPTHIEIHTRRRTVALVNGPERRVWPAGVGRPASPTPRGRTFVLGSVDIADGL
                     VDRAILLAAHMPTHLLHGTGLPAVGIHAWPGTVFGLAGSDGCVLVPDLALTDLEDAAPP
                     GTTVLIH"
     gene            complement(<3651..4775)
                     /locus_tag="BN1701_RS38260"
                     /pseudo=""
     CDS             complement(<3651..4775)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF042684.2"
                     /locus_tag="BN1701_RS38260"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="DUF6545 domain-containing protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MVFYLAATIAVALGLAKWVCEPSAPDLGVTLVVAALLSLGGAVAL
                     GAPLTAALVPSGPLYQARQVGVAVLVFLGGSCVLSALDYSDVGERRIRDRALGRTGVAL
                     VAGSWFCIFSAFGAMAPVDRSLDARYCAWIAMVIFLGYVGYVTAVAYRFATSHTTRGET
                     FALLVRGLQVVRCGLCVSGLWVALKLVSIVVAVADPNVLVVMEQTAHVVASVALASLVL
                     GGLMISWATDLVLSRHRARTRRALASVLPLWTSLVAAIPEIELNLTDVDVEDVDLLCRR
                     LVEIRDAQIRLRAHVPPWLADSVAAAAQTGNWPTESTRVITEAAELVVALRAIELGLPP
                     ARSSAEAVTFAEHETWTFGYQDLFDEAIWLARVRK"
     gene            complement(4784..5341)
                     /locus_tag="BN1701_RS20035"
     CDS             complement(4784..5341)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="BN1701_RS20035"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_157368109.1"
                     /transl_table=11
                     /translation="MTYLRIREQCVLLIDGLGISEPFDMAVLLRAWPEKFGARIELVPA
                     KLGSSLPCGLLVSTGEIHYVCYDATASPLHRTQIICHELGHVALGHTEPVDDSLDKRLG
                     HLEPVAGLEILHRLMPTLSPGLIRRLMGRTVYDAEQERDAELFALLLVAAVARNSTHRS
                     TAVGPTLGRLPGLLACGSRSRC"
     misc_feature    5452..5472
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 21.0"
                     /tool="antismash"
     gene            5632..5871
                     /locus_tag="BN1701_RS20040"
     CDS             5632..5871
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013676460.1"
                     /locus_tag="BN1701_RS20040"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_054051109.1"
                     /transl_table=11
                     /translation="MDESGVSAQSRPPRPFLSVSEAAELMRVSPMSLYREIAAGRFPAV
                     RIRSRLVVPARALSDMETAALKSGAVVDAAEWAG"
     gene            5961..6134
                     /locus_tag="BN1701_RS35785"
     CDS             5961..6134
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="BN1701_RS35785"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_157368110.1"
                     /transl_table=11
                     /translation="MPGRHQIGENRRQPSSRTGIDATPTVTGHGAIAEAIANRLAVRVI
                     ASVVSQRNAYAA"
     gene            complement(6464..6652)
                     /locus_tag="BN1701_RS35790"
     CDS             complement(6464..6652)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="BN1701_RS35790"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_157368111.1"
                     /transl_table=11
                     /translation="MVDTVRLVEFIPLNGFTSMAEIPLPDGMLLRPMTDRQMSRAIQVL
                     AAPAELHAQHQRTPCAA"
     gene            complement(6613..6981)
                     /locus_tag="BN1701_RS20045"
     CDS             complement(6613..6981)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="BN1701_RS20045"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_157368112.1"
                     /transl_table=11
                     /translation="MPDLRNWWRYGQESFVALRPNAWYMPERVTVVNWLDTFAEMVAVR
                     NVIDADPILSTRVDTMVGTEFSLQQRRLDWVLVECLLEPVIATMRTYELDEAVFDQQYA
                     SSKLAFWSTPFGSSSSSR"
     gene            7244..8800
                     /locus_tag="BN1701_RS20050"
     CDS             7244..8800
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF016232.4"
                     /locus_tag="BN1701_RS20050"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_054051112.1"
                     /transl_table=11
                     /translation="MAQPQAHEPVVIEPVVNREKLRELLALETEYPTLDFKSGCDLGEK
                     REQVEVAKDVGAMSVRGGFLVIGVDGQGKPTGNMTVEQAKLFDEARLRPRLLKWLPDTL
                     ELYSQAHEVDGNRVVVVHVAPNPAGCAIFRADGQYDQPGKAPKVVFREGEVFYRDGTQS
                     VRLNHQGLEQVIRQRVDRERGRWEAERAESYRRLADELRVGAAGQHVAQGPTVEFNLAL
                     EPDVLVEAAIELLRANDDIPLRRLLSRAVPDLRDLFRSGNEESVTGQIDRLTCLAATFL
                     ELGRHEWFKQVLDTLVSIYGIGFENEAPIVNAPPRRSAALWLALIERVLALGSLAVRRS
                     DWQAVRDLVARRHPDMHGMYTTWLRHAMTMASRAELLTTRDGGEDVFDSLLSRARNVVR
                     HLEWLRPDVEPEDEKVLTGLTQFDFLADLVAMADSNNNSGIFPNFARFYAERTQPAAQR
                     LLREPTMRTIIYPGDDQHLAAALRTIDREARQAGFHYDGWDGYTQDVNTFIREHTADND
                     Q"
     gene            complement(8853..9824)
                     /locus_tag="BN1701_RS20055"
     CDS             complement(8853..9824)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="BN1701_RS20055"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_197672119.1"
                     /transl_table=11
                     /translation="MNKAALIASDCGLPDLARDMCWQHINLYREADRPLTVLQARHMLE
                     PVLNLARLQLRAYDGEQALQLLTDMFQAVRSKTDLVVDERTLPLAELVGTRAEHHKLHE
                     WVWLHLIGDGIRALTLAGRWDDAVSHASAHRGIGLHLMEGRQATIVAHYINGDVTGAQA
                     ALAESTPQQPWELQVASCLKVLCTESDSRSTHQDAVAMIAHFVEHQPMAGYAVFRAQFG
                     LTVTTLADAVDPETAGRLLAQVTDEVIESGDGYAAREVLRSSNTPATGKQLAALVDLVT
                     TSGLGTGTLPEPVQRSLLDSTETAAQVLRVTLRQPEQRTTRA"
     misc_feature    complement(8886..8888)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(10001..10987)
                     /locus_tag="BN1701_RS37415"
                     /pseudo=""
     CDS             complement(10001..10987)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR03891.1"
                     /locus_tag="BN1701_RS37415"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="thiopeptide-type bacteriocin biosynthesis
                     protein"
                     /pseudo=""
                     /sec_met_domain="Lant_dehydr_C (E-value: 7.9e-22, bitscore:
                     76.8, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGRMPADHLTTRQTNAPADLAVAVLAVLAGDDPATVAANHAVNPA
                     DLRDAVGTYQAAGLAALQRQDEGNWYQVRVQFRDWSAAETVGATALGPALDRLRADGAT
                     AGWWFLRKHPCWRLRLARADVGAVNRVLDDLTGTGVIARWWSTLYEPETAAFGGSTGMD
                     TIHDLFCADSAGVLDYVR"
     gene            complement(10960..12174)
                     /locus_tag="BN1701_RS20065"
     CDS             complement(10960..12174)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF017000.4"
                     /locus_tag="BN1701_RS20065"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_082859943.1"
                     /sec_met_domain="LANC_like (E-value: 1.3e-45, bitscore:
                     154.3, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTPGTNPSPDSSEVTLTLDEVSSQSLARGAVGTALLHVERAWTGS
                     GSWESAQAHIRHVVAGPVDAAEHAGLYYGAPAVAFLLRAAADRHPRYRAASQTIDEHVL
                     HLARRRLATAATRITRGEPAVFAEYDLFYGLTGIGALLLRHHSDSDELTRILRYVATLA
                     TQPHREDGVELPGWWVAHDPDEILSTPGGHANFGMAHGAAGLLSLLALASLRGRVVDGH
                     HEAIAKLTAWFDRWRQDGPDGPWWPQWITREELRTGRPTRTRPGRASWCYGTVGIARAQ
                     QLAALATDEPRRQDAAEDALVAGLTDTQLDRITEPGLCHGIAGIYQTAYRASDDARGPA
                     IAHRLPALADRLTAHTRSLGEDTDNDEPNAAGLLTGRAGVDLALETVRHTTPPHTGWDA
                     CLLIT"
     gene            complement(12171..15308)
                     /locus_tag="BN1701_RS20070"
     CDS             complement(12171..15308)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF016615.4"
                     /locus_tag="BN1701_RS20070"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_054051118.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 1.2e-201,
                     bitscore: 669.9, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 2.2e-20,
                     bitscore: 71.8, seeds: 20, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTVSPRYQHAGLALARVTTDPGDLDPPTHLNLTDPAVVEQEGRAW
                     LAKVWARPEVRDALTLASPVLGARLDRILVDGTTARTAKELRRAVVSVASYLLRWHRRA
                     TPFGLFAGVGNVGVGPAMAKVGTQHRVVARVDGEWLTTLIDSLERHPDLRQRLTVVVDD
                     TRVVRDERVIVHRRAEVGAATPGPLRESSVRLSRPVRFVLTAAGSPIRFDTLADQITAR
                     FPSASTGKIHALLHGLIDAGVLITSLRPPMTSTDALTHLIWALRSAETDALDDVAAHLH
                     DLEAISADLARHNHTSDPEQARAIRAAVTRRMAVLVPEAGHVLAADVRIDAKIAIPERV
                     LNEAARAATVLLRTSTQPFGSAAWLDYHARFRARYGPGALVPVWDLVADSGLGYPAGYL
                     GAPRARPAWRVLTDRDAALLALIQQATLTGAREIELADADIEALTVGEHAKAIAPQRVE
                     VGVELHAASTAAIDRGDFGLRVTAAPNAHTSMAGRFAYLLDEDDHARLAATYTAGTERL
                     SQNGSDTAIAAQLSFPPRRPHNENVVRVPPLLGAIVSMSEHPDPTRSDITFIGVDDLAV
                     TADAEQMYLVQVSTGRRVIPRIPHALDTAVQSPPLARFLAEVADARSAVFRGFDLGAAR
                     TLPYVPRIRYQRTVLSAARWILSGADVAARPGTHDKDEALRSWRQRWRVPARVVMVHRE
                     LRLPVDLDQKLDRALLRAHLERVDRVELHEDGPPDGQGWIGRPTELLIPMIAITPPARP
                     LPVTAAPGSALQPGDSAMVHAQLVGNPARFDEILTAHLPLFIAELHDLSDVDGPVVSWW
                     VRRHRDMIRPEADQHLAVFVRLTGAQHYGAVAARLAAFAADLDSRGLPGQLTLAPTPQH
                     PARYGDGPALAAAELVFATDTTAAIAQLAAAQASGIPAQALAAASMAHLAASFAPDPQT
                     GYRALLDCLGQEHGPQDRALRDHTLAVADPDQQYRAVRALPGGDAVASAWRARDTALNT
                     YHGALAQHGREPSVVLRTLLHEHHIRAVGVDPTFERETGRLARAVALRRLALARAR"
     aSDomain        complement(14556..14837)
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_BN1701_RS20070_Lanthipeptide_LanB_RRE
                     .1"
                     /evalue="8.70E-23"
                     /identifier="RREFam001.1"
                     /label="BN1701_RS20070"
                     /locus_tag="BN1701_RS20070"
                     /protein_end="251"
                     /protein_start="157"
                     /score="71.8"
                     /tool="antismash"
                     /translation="TVVVDDTRVVRDERVIVHRRAEVGAATPGPLRESSVRLSRPVRFV
                     LTAAGSPIRFDTLADQITARFPSASTGKIHALLHGLIDAGVLITSLRPP"
     misc_feature    complement(15051..15053)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(15401..15592)
                     /locus_tag="BN1701_RS20075"
     CDS             complement(15401..15592)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LD_lanti_pre"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:TIGR04363.1"
                     /locus_tag="BN1701_RS20075"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="FxLD family lanthipeptide"
                     /protein_id="WP_054051120.1"
                     /sec_met_domain="LD_lanti_pre (E-value: 7.3e-15, bitscore:
                     53.3, seeds: 21, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSAALAVDYAESPDAAVDDAEFELDMRVVESTTKLVIMMCDTSDG
                     CGNTCSTSACSTGSNDPF"
     CDS_motif       complement(15491..15592)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MSAALAVDYAESPDAAVDDAEFELDMRVVESTTK"
                     /locus_tag="BN1701_RS20075_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(15401..15490)
                     /prepeptide="core"
                     /locus_tag="BN1701_RS20075_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class I"
                     /score="-10.40"
                     /molecular_weight="2756.0"
                     /monoisotopic_mass="2754.1"
                     /core_sequence="LVIMMCDTSDGCGNTCSTSACSTGSNDPF"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MSAALAVDYAESPDAAVDDAEFELDMRVVESTTK"
                     /leader_location="[15490:15592](-)"
                     /alternative_weights="2774.1"
                     /alternative_weights="2792.1"
                     /alternative_weights="2810.1"
                     /alternative_weights="2828.1"
                     /alternative_weights="2846.1"
     gene            complement(15605..16882)
                     /gene="fxlM"
                     /locus_tag="BN1701_RS20080"
     CDS             complement(15605..16882)
                     /GO_function="GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="fxlM"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PCMT"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Methyltransf_3"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:TIGR04364.1"
                     /locus_tag="BN1701_RS20080"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="methyltransferase, FxLD system"
                     /protein_id="WP_054051122.1"
                     /sec_met_domain="PCMT (E-value: 1.4e-28, bitscore: 98.8,
                     seeds: 9, tool: rule-based-clusters)"
                     /sec_met_domain="Methyltransf_3 (E-value: 2.1e-06,
                     bitscore: 25.8, seeds: 4, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNTLRHDDASVTEFRDALVDKLLADNMITSSRVERAFRTVPWHLF
                     VAEGTPLEATYNVDNPVAIKRDRDGVIISSTSAAYIQAQMIEQAEIAPGMSVLEIGSGG
                     YNAALLAEVVGPDGRVVSVDIDPEVTDRAQELLDATGYGSRVTVVLADAGHPLPGLDER
                     FDAILVTVGAWDLAPAWLEHLTADGTIVVPLRMNGITRVIGFRREGDHLVSTSVAVAGF
                     VPMQGEGTRDERVFLLPDRNGHHVKLRFDDEVPQDMSLLDGVLATDRTEAWSGITIKHG
                     VSFAGLHLWFAAFLPGFCKLAVDDGTDLAAERKGWFPFGVVHGDSFAYLAVRPLPEGSG
                     VEFGAPAYGAHGEAAATAMVEQIQVWDRQGRDAEPTFTYWPTGAHRPEFGENTAVLVKA
                     HGVATISWPSAADAPDGQGVPHNPEK"
     gene            complement(16978..17325)
                     /locus_tag="BN1701_RS20085"
     CDS             complement(16978..17325)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="BN1701_RS20085"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_054051124.1"
                     /transl_table=11
                     /translation="MDEFLADALRRAVHDRLDYLDKLATDADLRSRAALADTEIVRLTA
                     AWRTLLDAHRPDHQGRYPECSGWRRPRPHPCSVWTTAHQHLIAADGPPVHRTGKHAAVA
                     GRSTAAMLEAS"
     gene            complement(17318..17479)
                     /locus_tag="BN1701_RS35795"
     CDS             complement(17318..17479)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="BN1701_RS35795"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_157368113.1"
                     /transl_table=11
                     /translation="MANALGKIVNLAVCRAWTTGELLDPAEHTTFERCEFCVQILNDLR
                     LVQGADHG"
     gene            complement(17566..18009)
                     /locus_tag="BN1701_RS20090"
     CDS             complement(17566..18009)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="BN1701_RS20090"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_054051126.1"
                     /transl_table=11
                     /translation="MDACAQYEEHLGWSVRVDVTARCLALSAGQTIDALTMPAPLARRV
                     HAALDVMLLAGPAIATPNSAWWTLLTDRSAAEQPSVPHDVVAAGVCAVARGDHVRVPTH
                     LTDMNGAAWRWTRMPLGRRPLPPWSAVVGATRRVLAQLAGGSA"
     gene            18324..18572
                     /locus_tag="BN1701_RS35800"
     CDS             18324..18572
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="BN1701_RS35800"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_157368114.1"
                     /transl_table=11
                     /translation="MAFNFLPVKFTDASFDAGTQSYKSPEQLDALRARLAKSHSVIRLR
                     SQIVCVPITRDAEVVGEPTRFDTRGPNLALTAYLLQG"
     gene            18578..19717
                     /locus_tag="BN1701_RS20095"
     CDS             18578..19717
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="BN1701_RS20095"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_054051128.1"
                     /transl_table=11
                     /translation="MLTERWKFSLRRFDPLTFVSRLPNRDLMQKALKDRHPIEGLHVYP
                     EYELDVRRSGPMGYAGIIVGLKTRYEISLPVSELIELGVHMVGQYVLTETDSVPERPFQ
                     DPIARRRLAGVVEAVDQDRVVLGTSDGRIEVPASQAWLESRRDNFLAVVEAVAGASATS
                     ITDALEYQVFTVTGAEGRMARTQEIADGLIKLGPLTIANDIQATIGNGVKITAPSDRKT
                     HWRLPEPTYVFDLGGDKTHPFPDPGLNQFGPFDSEGFTPKIPRIAVVTPKQHQGAVEGF
                     MSSFRNGVRGASAFSQGFVRKYQLTDCALVFTPFDGDVCDAAAYRQACRNALEGDEPPD
                     RATRAWRSSSIWRRASWCWWSGSPVRWRAGPSSTRRTTS"
     gene            19714..19839
                     /locus_tag="BN1701_RS37875"
     CDS             19714..19839
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="BN1701_RS37875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_255364639.1"
                     /transl_table=11
                     /translation="MTDEVMDAGLSEKAIKALEAIVLEGYKGWTDAICSDRSWSS"
     misc_feature    19780..19782
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    19938..19951
                     /note="TFBS match to CatR, H2O2-responsive repressor,
                     confidence: medium, score: 19.64"
                     /tool="antismash"
     misc_feature    complement(20074..20088)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: medium, score: 18.82"
                     /tool="antismash"
     gene            20084..20740
                     /locus_tag="BN1701_RS20100"
     CDS             20084..20740
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="BN1701_RS20100"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_054051130.1"
                     /transl_table=11
                     /translation="MITQQTFIIPPEIEAGLLNGDLKLWGGVVRNLSGKIVKHLEEVKV
                     PAQAGESAAVSTASSNVRSWSGLAGDLKNPWLIIPAAVVGTLAAGSAVYVAVKKHRQAA
                     TAEVPEVVASYNTSLRGYLEAVREGRLSEEIIGKLISDLDAVVAYEEGGTISLDFSSKH
                     VETLVGIVVDATKQLVEANDLDLDELQEQVPAEDDNVVDLRRYLEVQKRIFKDAG"
     gene            complement(20975..21877)
                     /locus_tag="BN1701_RS20105"
     CDS             complement(20975..21877)
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1077: phage integrase
                     family protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015099461.1"
                     /locus_tag="BN1701_RS20105"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="tyrosine-type recombinase/integrase"
                     /protein_id="WP_054051132.1"
                     /transl_table=11
                     /translation="MTASEVLPDSDVVLRLACAAYLARFTGSSRVHTESDLRIYLAWCA
                     ARQFAPLGMVRADVERYVRWMQEIRRFKPSTVSRRMAVVAGFYRTCVIDSVLEHSPADY
                     VRRPVVANESPTLGLSHLQFEALLTAARDSSNRFDFALVAMLGLLGLRIFEACGSDITD
                     IGEEHGHRVLRVIGKGTKVTLVPLPPAVGRALDRAVHDRTSGAILLNRRAARMDRHCAT
                     RRLRHLAAVSIVRLPRMHPHMLRHTFVTTILDAGVDLRDVQIAARHADPRTTMRYDRAR
                     TNLDRHPNYILAAYMASGT"
     misc_feature    complement(21425..21427)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(21434..21436)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(22420..23364)
                     /locus_tag="BN1701_RS20110"
     CDS             complement(22420..23364)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020659314.1"
                     /locus_tag="BN1701_RS20110"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="S-4TM family putative pore-forming effector"
                     /protein_id="WP_054051133.1"
                     /transl_table=11
                     /translation="MTTPRSIDQRQLDGDMVRLQRAAAASHQRGQAVEAVRTTAAGLLA
                     AAGVVVTLAGPGRQAMAIIGFAWFLVSAFPLRRAAAAIALQGALLQEMFDTSLFRLPWR
                     TMVAGDPIPEAEVHRLARRLKSGCAKDNRIAEGWYDPTGGVHHPYDVLMAQEQNLAWDA
                     RLRRRYAAVLLTAAACWSLLGAVTGILVSGTTLTEVLLGFYVPSLSAYQLVCEIWAAQQ
                     RVAAERERLVRIVTSELRAARPGSLDDVEQRRLCEVARDVQDGILRTRVDPTRVPEWFY
                     RRRRPNDEMDFAATTANHQRRLIDDCGIPPSRR"
     misc_feature    23651..23664
                     /note="TFBS match to RpoN, Regulator of nitrogen
                     assimilation and virulence, confidence: strong, score:
                     17.31"
                     /tool="antismash"
     misc_feature    24061..24073
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 20.41"
                     /tool="antismash"
     misc_feature    complement(24614..24627)
                     /note="TFBS match to CatR, H2O2-responsive repressor,
                     confidence: medium, score: 19.79"
                     /tool="antismash"
ORIGIN
        1 accagagcga acgtgccgac cagaccgagc gcgatgtcgc gcagggcccg gccgctggtt
       61 gatgtcagcc cgccctgggc cgtctcccac gctgtgatga atgcggtggt catcgcggcc
      121 ctccggcgtc gacggtgatc gcggagagca gccagatccc gtcccgatcg ctgatggcga
      181 ttcgataggt gcacgcgagg gtcgcgtcgc cgggcaagcg ccaccgcacg gtcgcggtcc
      241 cgatccggac accgctgttg tcggccttcg gtgccactcg ccactcgtcg agttcggcca
      301 gttcagccgc cccgtcgagg ccgaggaagc ctgcgcccgc cgcgcggacg aactcgaggt
      361 cgccagtgcc gtatgcggtg agcagtttgc tgacgacgac ggtggtgtcg gcgctgaagt
      421 ccgcgtccgg cggttccgtc gccgcgtcgt tcccgagatc cgcgctgtgg ccttggccga
      481 cgagtgcggg tctgccggac aaggcgaagc gcccgccggg caaggagcgc acggggatgg
      541 cggccgtgag ccatcgagcg ggaagagctg tccaggacgc cttgagccca ccgggttggc
      601 tcggtgcggc gggcttggtg aacgggatga cgtgcacctg cacggtgacg acagcgagtt
      661 cgcgggcgaa ccggttgacg tcgagtacgg cgaccccgtc gacccgctgc ttgcccgcgc
      721 cgttccagcc atcgatgtcg gctcccggct cggcgatgcg gtcgagcgcc gtggttcgcg
      781 agggcttgtc ctcctggtcc cacgcgaagt agtcggtcgc ggccaccgtc gcggtgcctg
      841 cgaacccgac cgggtccacc tggcgctccg cgatcggatc ggggcgcagc catgtccgaa
      901 cactgtcgat catcgacgcg gcgcccacca gcatgacggc caccgcggcg gacaggatcg
      961 cggcgcggcg gccgcggaca aaccatccgt cccgcggcgg actttgcatg gtctgccaag
     1021 ggttttgcct gcctgctcga cgccgcggcg gctgcggctg cggccatgac gttggcggcg
     1081 cggaaccgag cgcggcatga ttccactctc ggttcggcga ttgacgcctc tgcgccaccg
     1141 tgacttccgg tcgaacccga cgacctgttg ttcgacccgg attccttgtg cccgagagag
     1201 ctcgagtcca cttgctcaac ttcctgctgt cggcacgcat atctccccct tcttgatccg
     1261 cctcggcgcc ccgcgtatgg gaacgcgccg aggccaggag caccgatgca cgacgggcgt
     1321 ccactgagga cgtccgcgtc ctcccaaagc cgagtacagc tctcccaccg cagccccttg
     1381 cggatcgaca gcagaccgaa ggcaccgcac ccggcggttc gcccgcgcgg cgcggatcgg
     1441 tgatactccc ccatgacgac cagtgaccgg ccgacttcct cccggcgcgg tactgagtta
     1501 tcgtcttccc tgagtcgaga atagccggga atgcggtcgc gtcaactcac tatcgcatca
     1561 aatgatccac acgagggggc aggacggtga tggcgaaggc caactcgtcg cctgggatgc
     1621 tggcggaacg gctgcggacg ctgcgggagt cggtcaggcc atcgccaacg gcgcggtaca
     1681 gctacgccgc catcgcggcg ggctgtcagg actacctgca ggatccctac ccgcccagcc
     1741 gcgagtacat ctccagcctg ttcaacggca aggccgacaa ccccacccgc aggatgctcg
     1801 aggccctagc ggacttcttc gacgtcagcc ccgcatactt cttcgacgac gcagcatccg
     1861 tggcgatcca gcaagacctc gagctctacg ctgtgctcgc cgagaagggc atcagccgcg
     1921 tccagctgcg cgcgctggcg aacctggacg aggacggcat tcaagccgtg cgagagctgc
     1981 tgacaaagct gccgaccacc gactgacgcc gcccgctcag cgcgtccacg tcacgcgctc
     2041 ggacaggccc acggtggcga gcaccagagc cgacaggccg caccgtcaga atcgagcttc
     2101 aagcacgtgg cctggccagt gccgacatga tcaccatcgg caacgcgatg cgatagccag
     2161 ttgacaactt acgcagaaaa catcaccctt aggagggtga ttccagtcaa ctggacatcg
     2221 catcattgat ctggatgggt agcgcagtcg tctcgacact tcgcgggacg agtgagcttc
     2281 acggggggtg atcagcgtgg aagtgctcgc cattcctgaa ccgggacgct gcggttggca
     2341 gctcctgccc gcccagaccg cggtcccgcg ctggctggca gcgagaatcg actggtacgt
     2401 gcgcccttcg gcggcccgca ccgcagccgc ctcgatcggc cgggtcctgt gcgaacacgt
     2461 cgactgggag tctgtgtggg cgcgcgaccg cggcctgttc cttcgccgcg agcacctcgg
     2521 cgccccaccg ccacctgtct tctttcacgc cgccgcgaca ctcgccgccc tcggctctac
     2581 gttgcttctg gaagtcgagc tcgagatggt cgccgacaag ctggcgttgg ccgtgtacgg
     2641 caccggtgtg cgcggggcga tgacatctga ggcatggcgt tcggtcgcgg gactcctgac
     2701 cacgtgcgcg tcgacggtgc gcgaaccatg gccgaggcag ctgcccgtcc ggccacatgt
     2761 cagtccggcc gcatgggtgc acgacgacca ctacacgtgg tggtcgtatc cgttcgcggg
     2821 cccggtaaga gagtcctgcg ggtgcgccgc ggagcacggc caaccgggcg caggcttcgg
     2881 cccgaagccg ggcgggcaca ggcggggatg aacgcatgcg aatcccgtca tcgagagtcg
     2941 gcgagagcac gccgccactg gcctcgtggt catcgctgat ccccggactg gcccgcgaca
     3001 gcgcatcgaa gtccagggtc atacgtttgc gtctccaccc gttgatcacc gttccggtgt
     3061 tccggacccc atcagagggt gcgccggtgg cggatctccc gacctacgcg tacggcctgc
     3121 tccggacatg ggttccgatc atcgacgcgc gtccgggatg ggcgttggtt ctgttgccgt
     3181 gtctgcctga cgggtcagtc ggttgggtgc ggctcgacga ccgggttgtc atcgtcgccc
     3241 agcccaccca catcgagatc cacactcgac gccgcactgt cgccctggtc aacggaccgg
     3301 agcggcgcgt ctggcccgcc ggagtcggcc ggccggcctc gccgacaccg cggggccgca
     3361 cgttcgtcct cgggtcggtc gacatcgccg acggccttgt cgaccgcgcg atcctgctgg
     3421 ccgcgcacat gcccacccac cttctccatg gcaccgggct accggccgtc ggcatccacg
     3481 cctggcctgg cacggtgttc ggcctggcag gcagtgacgg gtgcgtcctg gtacccgacc
     3541 tcgctctcac cgacctggaa gacgccgcac ctcccggcac cacggtcctg atccactgac
     3601 cccggcgacg cgttgcctgc gagacttgtg acggccttgc tcctcatcgc tttgcgcacc
     3661 cgtgccaacc agatcgcctc gtcgaacaag tcctggtagc cgaaggtcca agtctcgtgc
     3721 tcggcgaagg tcaccgcctc agcggaggat cgcgcaggcg gtagccccag ctcgatcgca
     3781 cgcagtgcga caacgagctc tgcggcttcg gtgatcacgc gggtcgactc ggtcggccag
     3841 tttcccgttt gggcggcggc ggcgaccgag tccgccaacc agggcggaac atgagcacgc
     3901 aacctgatct gagcgtcgcg gatctcgacg agtctgcgac acaggaggtc gacgtcttcg
     3961 acgtcgacgt cggtcaggtt cagctcgatc tcgggtatcg cagcgaccag ggacgtccag
     4021 agtggcagca cactggccaa cgctcggcga gttcgcgccc gatgcctgga gagaacgaga
     4081 tcggttgccc acgagatcat gagcccgccc aagactagcg acgctagcgc cacactcgcc
     4141 acgacatggg cggtttgctc catgaccaca aggacgttcg ggtcggcgac agcgaccaca
     4201 atggacacga gtttgagcgc cacccacaaa ccgctgacgc aaagcccaca ccgaaccacc
     4261 tgaagaccac gcacgagcaa ggcgaaagtc tcgcctcgtg tggtgtggga agtcgcgaat
     4321 ctgtacgcca cggccgtcac gtacccgaca tacccgagga agatcaccat cgcgatccag
     4381 gcgcagtacc gggcatcgag gctgcgatca acaggagcca tcgcaccaaa ggctgagaag
     4441 atgcagaacc atgagcctgc aacaagtgcg acgcccgtgc gaccgagagc tcgatcgcga
     4501 atcctgcgct cgccgacatc ggagtagtcc aaggcggaca gaacgcatga cccacccaag
     4561 aagaccaaga cagccacgcc gacctgcctt gcttggtaca aggggccgga aggcaccagt
     4621 gcggcggtca gcggtgctcc cagcgccacc gcgccgccaa gcgacagcag agcagccacg
     4681 acgagggtca cgcccaagtc cggtgcgctc ggctcgcaca cccacttcgc caacccgagc
     4741 gcgacggcga tcgtcgcggc caggtagaac accatgctga cggtcagcaa cgcgacctcg
     4801 atccacaggc gagcaagccg ggcaaccgcc cgagtgtcgg acccaccgct gtcgacctgt
     4861 gggtcgaatt tcgtgccact gcggcgacca acagcaaggc gaacagttcc gcgtcgcgtt
     4921 cttgctcggc gtcgtagacc gtcctcccca tgagccgcct gatcaggccg ggtgagaggg
     4981 tgggcatcag gcggtgcaat atctcgagac cggccaccgg ttcgaggtgg ccaagccgct
     5041 tgtcgagaga gtcgtccacc ggctctgtat ggccgagcgc gacgtgtccc agctcatgac
     5101 agatgatctg agttcggtgc agcggcgacg ccgtggcgtc gtagcacacg tagtggatct
     5161 cgccggtgct gacgagcaac ccacagggca gcgatgagcc gagtttcgct ggcactagct
     5221 caattcgagc accgaacttc tcgggccaag cacgcagaag taccgccatg tcgaacggct
     5281 cggaaatacc caaaccgtcg atcaacagca cgcattgttc acgaatacgc aaatacgtca
     5341 tcgcgccccc atcccccacc gcgacgcaca cccacatcca acgcggccaa gacccagcgt
     5401 agcagctacg ttccgctatc actacagctc agagcatcgc atcttctcac ttacgcgtca
     5461 cattgagtaa tatcgcacat ttcaagaaac gcagcacggt gtcactcgtt tgggttggcg
     5521 aacactcgtg ttgtcgcggc cagcaatcga tcgtgagttc tccgtgaccc ttgacggcga
     5581 caggtttcgc gcggacgatg aagagatcag acacctgatg ggggagagaa aatggatgaa
     5641 tctggggtat ccgcgcagtc gagaccacca cggcctttcc tgagcgtctc cgaagccgcc
     5701 gagctcatgc gagtctcgcc gatgtcgctg taccgcgaga tcgccgcggg gaggttcccg
     5761 gccgtccgga tccgatcgcg gctggtcgtg cccgcacgcg cgttgtccga catggagacc
     5821 gccgccttga agtcgggagc ggtcgtcgac gccgccgagt gggctggatg aattggcccg
     5881 tcggacagtg atccctgggc cctacgcccg tgtagggccc agctctactg ttcgtcacac
     5941 tgtcgatcga tgatcccctg gtgcctggcc gtcaccagat tggcgagaac cgccgccagc
     6001 cgagcagcag aaccgggatc gacgcgactc cgactgtcac cggccacggt gcgatcgccg
     6061 aggccatcgc gaatcgcctg gcggtgcggg tgatcgcctc ggtggtgagc cagcgcaacg
     6121 cgtacgccgc gtagccttga cggagatcgg caggacgatg gcgctgttgg cctccaagcc
     6181 gtcgacaagc cacggcaacg gtttgacgat ccaaaaccgg cgagctgtcc aagtccgacc
     6241 cggccggacc acaccgatac cgcagccaac cccgatgagg accaacggcc acggccgagg
     6301 cgcccgcttc ggcgaaacct cccggtactc gcccgctgat gtcgcgccac gggcgctccc
     6361 actggagtcg gtccgggact cgccagattg gtgcatctgc tcggtgaacg gcgccacatc
     6421 ggtgttggat gccgccttct tggcgacccg ctggcgcgat tcctcacgcg gcgcacggtg
     6481 ttcgctggtg ttgagcgtgc aactcggctg gcgccgcgag aacctgaatg gcccggctca
     6541 tctgccggtc ggtcatcggg cgcaggagca tgccatcggg cagcgggatt tcggccatgg
     6601 acgtgaagcc gttcagcggg atgaactcga cgagccgaac ggtgtcgacc aaaaggccag
     6661 cttcgagctg gcgtattgct ggtcgaacac tgcctcgtcg agctcgtagg tgcgcatggt
     6721 ggcgatcacg ggttcaagca ggcactcgac cagtacccag tcgagcctgc gctgttgcag
     6781 cgagaactcg gtgccgacca tcgtgtcgac gcgggtgctc aagatcgggt cggcgtcgat
     6841 cacgttgcga actgcgacca tctcggcgaa cgtgtccaac cagttgacca cggtgacccg
     6901 ctcgggcatg taccaagcat ttggccgcaa cgccacgaag gattcctggc cgtatcgcca
     6961 ccagttccga agatcgggca tattgccgac ctctgggata ccgtcgcgtt ccgcgagatc
     7021 acctagcgcc gctatggcca acgacgcaac tgccgctcga acagccggcc tctcacacgc
     7081 cttcatctac tgacccaact cgtcgcgcgt cctgctcgcc gaggacccag tcaggcgcga
     7141 gccagccaga atgccacgaa ccggtcagcg accccaagcg agttggacca gacacgccga
     7201 cgatttccgt gagcgctgac gttcgactcc gtatcctcgg cggatggccc agccgcaagc
     7261 ccacgagccc gtggtgatcg aacccgttgt caaccgggag aagctgcggg aactgctcgc
     7321 gctggagacg gagtacccga cactcgactt caagtcaggc tgcgaccttg gcgagaagcg
     7381 ggagcaggtc gaagtcgcca aggacgtcgg cgctatgtcg gtgcgcggcg ggttcctcgt
     7441 catcggcgtc gacgggcaag gcaagccgac ggggaacatg accgtcgagc aggcgaagct
     7501 cttcgacgag gcacgcctgc gtcccaggct tctgaagtgg ttgccggaca ccctggagct
     7561 gtactcccag gcccacgaag tcgacgggaa ccgtgtcgtg gttgtgcacg ttgctccgaa
     7621 cccggcgggc tgcgcgatct tccgggcaga tggccaatac gaccagcccg gcaaggcgcc
     7681 gaaagtcgtg ttccgagaag gagaggtgtt ctaccgcgac ggaacgcaga gcgtcaggct
     7741 caatcatcaa ggtctcgaac aggttatccg ccagcgggtc gatcgcgagc gaggccgctg
     7801 ggaggcagaa cgcgccgaga gctaccggcg actcgccgac gaactccggg ttggcgccgc
     7861 cggacagcac gtcgctcaag gccctaccgt cgagttcaac ctcgccctcg aacccgatgt
     7921 gctggtcgag gccgcgatcg agctcctgcg cgccaacgac gacatccctc tccggcgact
     7981 gctgagccgg gccgtcccgg acctacgcga cctgttccga tcgggcaacg aggagagcgt
     8041 caccgggcaa attgaccgcc tcacctgcct cgctgcgact ttcctggagc tggggcgcca
     8101 cgagtggttt aagcaggtcc tcgacacgtt ggtgtcgatc tatggcatcg ggttcgaaaa
     8161 cgaagccccg attgtcaacg ccccgccacg gcggtccgcg gcgttgtggc ttgcgctcat
     8221 cgagcgggtg ctggcgctcg gttcgttggc cgttcgccgc agtgactggc aggcggtgcg
     8281 ggacttggtg gctcgacggc accccgacat gcacgggatg tacacgacgt ggcttcggca
     8341 cgcgatgaca atggccagcc gtgccgaact gctgacgacc cgcgatggcg gcgaggacgt
     8401 tttcgactct ctgctaagcc gcgcccgcaa cgttgttcga cacttggagt ggctgcgacc
     8461 cgatgttgag cccgaagacg agaaggtgct caccggcctc acccagttcg acttcctcgc
     8521 cgacttggtc gcaatggccg acagcaacaa caacagcggc atctttccaa acttcgcgcg
     8581 gttctatgca gagcggacac agcctgctgc gcaacggttg cttcgtgaac ccacgatgcg
     8641 aacgatcatc tacccaggag acgaccaaca cctcgccgct gcgctgcgca cgatcgaccg
     8701 cgaagcgcgg caggctggat tccattacga cggctgggac ggctacaccc aggacgtcaa
     8761 cactttcata cgcgagcaca ccgctgacaa tgaccagtaa taagtcatcg tctcccgaag
     8821 gtgttacgga ccgcgggaac gatctgctcc ggtcaagctc gcgtggtccg ttgctcgggc
     8881 tgccgtaacg tcacgcgcag gacttgagct gcggtttctg tggagtcgag caggctccgc
     8941 tggacaggtt ccggcagtgt tccggttccc aggccggagg tggtcaccaa gtctacgagc
     9001 gccgcaagct gcttgccggt tgccggagta ttactggatc gcaggacctc ccgagcggcg
     9061 tacccgtctc ccgactcgat cacctcgtcg gtcacctgtg ccaacagacg gccagccgtc
     9121 tcgggatcga cggcgtcggc gagcgtggtg acggtgagcc cgaactgggc gcggaagacc
     9181 gcgtagccag ccatcggctg gtgctcgacg aagtgcgcga tcattgccac agcgtcttga
     9241 tgcgtcgacc tgctgtccga ttcggtgcac aacaccttca ggcaggaggc aacctggagt
     9301 tcccatggct gctgtggggt gctttccgcc agcgccgcct gcgctcccgt cacgtctccg
     9361 ttgatgtagt gggccacgat cgtggcctgc ctgccctcca ttaggtgcag gccgatcccg
     9421 cggtgagcgg aggcgtggct aaccgcgtcg tcccaccgtc ccgcaagggt cagcgcgcgg
     9481 atgccgtcgc cgatgaggtg cagccacacc cattcgtgca gtttgtggtg ttcggcgcgg
     9541 gtaccgacaa gttcggccag cgggagcgtg cgttcatcaa cgacaaggtc ggttttggac
     9601 ctgacggcct ggaacatgtc ggtgagtagc tggagtgctt gctcgccgtc ataggcgcgg
     9661 agttggaggc gagcgaggtt aaggacgggt tcgagcatgt ggcgggcttg gagcacggtg
     9721 agggggcggt cagcctctcg gtagaggttg atgtgctgcc agcacatgtc gcgggccagg
     9781 tctggcagac cgcagtcgct ggcgatcagt gcggccttgt tcatggcgtg tgcgccttcg
     9841 gacaaccggt ccgcgccgac ttgcccggcg gcgtgggcga tgtcggcgat ctcctgtact
     9901 cgttcggaca acgccgggca ggcgggccgg ggacggccta tcagcgggaa gcggcggatc
     9961 acagcggcca gcgtgggcgg gttcgatgtg ggggtcatgg tcagctccgg ggcagcacgg
    10021 cggtggttgc cgcgcgggcg aggatgccct ggctcgcggc cgagagaccg aatcggttcc
    10081 agtggaagat cacgacgtgg gtgaggatgg cccgcaggcc gcggtccaag cgcccggtcg
    10141 ccgcatggtg gccgagccgt tcgccagcgg cacccaacgc cgcgagccag ggtgcggcgt
    10201 gcgcgactgg cccacccggt gtgaacagct cgctgtcggc caggttggag atcgacagga
    10261 gcacgcgcag gttgtcgacc agcttggcgg tgcgtgctgt gtcggtgcct gtgggtgcgg
    10321 gtcgcaggcg cgcgacgcgg tcgaatacgt cgccgcactc gaacgtgtcg agtccggcgg
    10381 cgcgcatcag ttcgctcagc agcaggatgg acagttcccg gcgtccgagc cctggggcgt
    10441 cctagcgtac gtagtcgagc acgcctgcgc tgtcggcgca gaacaggtcg tggatggtgt
    10501 ccataccggt cgaaccgccg aaggcggcgg tctccggctc atacagcgtt gaccaccagc
    10561 gcgcgatgac gccggtgccg gttaggtcgt cgagcacacg gttgacggcc ccaacatccg
    10621 cccgcgccag gcgcagtcgc caacaggggt gtttgcgcag gaaccaccag ccagccgtcg
    10681 ccccgtcggc gcggagccta tccagcgcgg ggccgagggc cgtggcgccg accgtctcgg
    10741 cggccgacca gtcacggaac tggacacgca cctggtacca gttgccttcg tcctgtcgtt
    10801 gcagcgctgc gagcccggcg gcctggtagg tgccgaccgc gtcgcgaagg tcggcagggt
    10861 tcacggcgtg gttggccgcg acggtggccg ggtcgtcgcc cgcgagaacc gccaacacgg
    10921 cgacggcgag gtcggcggga gcgttggtct ggcgggtggt caggtgatca gcaggcatgc
    10981 gtcccatccc gtgtgaggcg gcgtggtgtg ccgcacggtt tccagcgcca ggtccactcc
    11041 agcgcgtccg gtgagcagcc ctgccgcgtt cggctcgtcg ttgtcggtgt cctcgccgag
    11101 cgaccgcgtg tgcgcagtga ggcggtcagc cagcgctggg agccggtggg cgatggcagg
    11161 gccacgggcg tcgtcggagg cgcggtaggc ggtttggtag atcccggcga tgccgtggca
    11221 caggcccggc tcggtgatcc ggtcgagttg cgtgtctgtc aggcccgcga ccagagcgtc
    11281 ctcggccgcg tcctggcgtc gcggttcgtc tgtcgccagt gcggccagtt gttgggcgcg
    11341 ggcgatgccg accgtcccat agcaccacga ggctcggccg gggcgagtgc gggtggggcg
    11401 gcccgtgcgg agctcctcgc gggtgatcca ctgcggccac cagggtccgt ccggaccgtc
    11461 ttggcgccac cggtcgaacc acgccgtgag cttggcgatc gcctcgtggt gaccgtcgac
    11521 cacgcgaccg cgcaggctgg ccagggcgag caaggacagc agcccggccg caccgtgggc
    11581 catgccgaag ttcgcgtgcc cgccaggggt cgacaggatt tcgtccgggt cgtgcgccac
    11641 ccaccagccg ggcagctcga cgccgtcctc gcggtgcggt tgggtagcca gtgtggccac
    11701 gtaccgcaga atccgggtca gttcgtcgct gtcggagtga tggcggagca gcaaggcgcc
    11761 gatgccggtg agcccgtaga acaggtcata ctcggcgaag acggcgggct ccccgcgggt
    11821 gatccgggtg gcggcggtgg ccagtcgtcg acgggccagg tgcagcacgt gctcgtcaat
    11881 cgtctggctg gccgcgcggt agcggggatg gcggtcggct gcggcgcgca gcaggaacgc
    11941 gactgcgggc gccccgtagt agaggccggc gtgttcagcg gcgtcaaccg gccccgccac
    12001 cacatgacgg atatgggcct gcgcggactc ccagctgccc gagccggtcc aagcgcgctc
    12061 gacgtgcagc agcgcggtcc cgactgcccc tcgtgcgagg gattggctgc tcacctcgtc
    12121 gagggtcagc gtcacctcgc tgctgtccgg gcttgggttc gtgccgggcg tcatcgggca
    12181 cgagccaggg cgaggcggcg cagcgcgacc gcgcgggcga gtcgtccggt ttccctctcg
    12241 aatgtcggat cgacgccgac ggcgcggatg tgatgctcgt gcagcagcgt gcgcagcacc
    12301 acgctcggct cgcgcccgtg ctgagcaagg gcaccgtgat aggtgttcag ggcggtgtcg
    12361 cgggcacgcc aggcggaggc gaccgcgtcg ccgcccggta gcgcgcgaac agcgcggtac
    12421 tgctggtcgg ggtcggccac ggcgagtgtg tggtcgcgca gcgcgcgatc ctgcggcccg
    12481 tgctcctgcc ccaggcagtc gagcaaagcc cggtatccgg tctgcggatc gggcgcgaag
    12541 gacgcggcca gatgcgccat ggatgccgcg gccagtgcct gggcgggaat cccggacgcc
    12601 tgcgccgctg cgagctgggc gatagcggcg gtcgtgtccg tggcaaacac cagctcggct
    12661 gccgccaacg cggggccgtc gccgtagcgg gcggggtgct gcggggtcgg ggccagggtg
    12721 agctggccgg ggagccctcg ggagtccagg tcggcagcga aagcggccag ccgtgcggcg
    12781 acggctccgt agtgctgcgc tccggtgagg cgcacgaaca cggcgaggtg ttgatccgcc
    12841 tcgggtcgga tcatgtcgcg atggcgccgt acccaccacg acacgaccgg gccatcgaca
    12901 tcactcaggt cgtggagctc ggcgatgaac agaggcaggt gcgcggtgag gatctcatcg
    12961 aacctagccg ggttgcccac cagttgcgcg tgcaccatgg ccgagtctcc cggctggaga
    13021 gcggaaccgg gcgccgcggt cacgggcagc gggcgtgcgg gcggggtgat cgcgatcatc
    13081 gggatcaaca gctcggtcgg ccgcccgatc cagccctgcc cgtcgggcgg gccgtcctcg
    13141 tgcagttcga cccggtcgac ccgctccaag tgagcgcgca gcaaggcgcg atcgagcttc
    13201 tggtcgaggt ccaccggcaa acgcagctct ctgtggacca tcaccacccg tgccggtacg
    13261 cgccatcgct gccgccacga ccgcaatgcc tcgtccttgt cgtgggttcc tggccgggca
    13321 gcgacgtcgg cgccggagag gatccagcgg gcggcggaca acactgtccg ctggtagcgg
    13381 atgcgcggca cgtagggcag ggtgcgggcg gcgccgagat cgaatccacg gaacaccgcg
    13441 ctgcgggcat cggcgacctc ggcgaggaac cgggccagag gcgggctttg cacggcggtg
    13501 tccagggcgt gcggaatccg ggggatcacc cgccgcccgg tggacacctg caccaggtac
    13561 atctgttcgg cgtcggccgt gaccgccaag tcgtccaccc cgatgaaggt gatgtccgag
    13621 cgcgtcggat caggatgctc cgacatcgac acaatggcac caagcagcgg cggtacacgc
    13681 accacgttct cgttgtgggg gcggcgcggc ggaaaggaca gctgcgccgc aatcgccgtg
    13741 tccgagccgt tctgcgaaag ccgctccgtt ccagcagtgt aggtcgcggc caggcgggcg
    13801 tgatcatcct cgtcaagcag gtaggcgaac cgtccagcca tgctggtgtg cgcgttcggc
    13861 gctgcggtta cccgcaaacc gaagtcacct cggtcgatcg ccgcggtcga cgcggcgtgc
    13921 agctcgacac ccacttcgac ccgttggggc gcaatggctt tggcgtgttc accgacagtc
    13981 aacgcctcaa tgtcggcatc ggcgagctcg atctcccgcg ccccggtcag cgtggcctgc
    14041 tgaatcaacg ccagcagcgc ggcgtcgcgg tcggtcaaca cccgccacgc aggccgtgct
    14101 cggggcgcgc caaggtatcc agccgggtag ccgagccccg aatcagcgac cagatcccac
    14161 accggcacca gggcgccggg cccgtagcgg gcgcggaatc gtgcgtgata gtcaagccac
    14221 gcggccgacc cgaacggttg tgtactggtc cgcagcagca cggtcgcagc gcgcgcggcc
    14281 tcgttgagca cccgttcggg gatggcgatc ttcgcgtcta tgcgcacgtc ggcggcgagc
    14341 acatggccag cttcggggac aaggacggcc atccgtctcg tgacggccgc gcggatcgcc
    14401 ctcgcctgtt cagggtcgct ggtgtgattg tgccgggcga ggtcggcgct gatcgcttcg
    14461 aggtcgtgca ggtgggcggc gacatcgtcc aaggcgtcgg tttcggcgga acgcagggcc
    14521 cagatcaagt gcgtcaaggc gtcggtgctg gtcatcggag gccgcaggct ggtgatcagc
    14581 acaccggcgt cgatcaggcc gtgcagcaat gcgtggatct tgccggtgga ggcggacggg
    14641 aaccgtgcgg ttatctggtc ggcgagcgtg tcgaaccgaa tcggcgatcc ggccgcggtc
    14701 aacacgaacc gcacgggacg ggagagccgc accgatgact cccgcagcgg ccctggggtg
    14761 gcggcgccga cctcggcccg gcggtgaacg atcacgcgct catcgcgaac gactcgcgtg
    14821 tcatcgacga cgaccgtaag gcgctggcgc aggtcggggt gccgttccaa gctgtcgatc
    14881 agcgtggtca gccactcgcc gtccacccgc gccacgaccc ggtgctgggt gcccaccttg
    14941 gccatcgcgg gtccgactcc gacatttccg acgccagcga acagcccgaa cggtgtcgcc
    15001 ctccgatgcc agcgcagcag gtaggacgcc acggagacga cggcgcggcg taactccttc
    15061 gccgtgcgcg cggtcgtgcc gtcgacgagg atccggtcca agcgcgcgcc gaggacgggg
    15121 ctggcgagcg tcagcgcgtc ccgaacctcc gggcgcgccc acaccttcgc cagccaggcg
    15181 cgaccttcct gctcgaccac ggcggggtcg gtcaagttga gatgggtggg tgggtcgagg
    15241 tcgcctgggt cggtggtgac gcgggccagt gcaaggccgg cgtgttggta gcgcggggac
    15301 acggtcatgg cgattcgctc tcctcacccg ggctcggtct gtggcggcgc ctgccgccgg
    15361 cgcccaaggc gaactcgggc accgacggca ggcggttgga tcagaacgga tcgttggagc
    15421 cggtgctgca agcgctggtg ctgcacgtgt tgccgcaccc gtcgctcgtg tcgcacatca
    15481 tgatcacgag cttggtggtc gactccacca cacgcatgtc cagttcgaac tccgcatcgt
    15541 cgaccgcggc gtccggggat tccgcgtagt caacggccag tgctgccgac attcggttca
    15601 ctccttactt ctcggggttg tgcgggacac cctgaccatc gggggcatcc gccgccgatg
    15661 gccaggagat cgtggccacg ccgtgcgcct tgaccagcac ggccgtgttc tcgccgaact
    15721 cgggccgatg ggcgccggtc ggccagtagg tgaaggtggg ctcggcgtcg cggccctggc
    15781 ggtcccatac ctggatctgc tcgaccatcg cggtcgcggc ggcctcaccg tgagctccgt
    15841 aggcgggcgc accgaactcg actccgctgc cctcgggaag cgggcggaca gccaggtagg
    15901 cgaacgagtc gccatgcacg acgccgaagg ggaaccagcc tttgcgttcg gcggccagat
    15961 cggtgccgtc gtccacggcc agcttgcaga aaccgggcag gaacgcggca aaccacaggt
    16021 gcaggcctgc gaaggacacg ccgtgcttga tggtgatgcc ggaccaggct tcggtgcggt
    16081 cagtcgcgag cacgccgtcg agcaggctca tgtcctgcgg tacctcgtcg tcgaagcgca
    16141 gcttgacatg gtgaccgttg cggtcgggca ggaggaacac ccgctcgtct cgggtgccct
    16201 cgccttgcat cgggacgaac ccggcgaccg cgaccgaggt gctcaccagg tggtcgcctt
    16261 cacggcggaa cccgatgacg cgtgtgattc cgttcatccg caacggaacg acgatcgtgc
    16321 cgtccgcggt gaggtgctcc agccaggccg gtgcgaggtc ccaggccccg accgtcacca
    16381 ggatcgcgtc gaaccgctcg tccagtccag gcagcggatg cccggcgtcg gccaagacca
    16441 cggtgacccg gctgccgtat ccggtcgcgt ccaggagttc ctgggcgcgg tcggtcactt
    16501 ccgggtcgat gtccacgctg accacccggc cgtctggtcc gacgacctcg gccagcaggg
    16561 ctgcgttgta gccgccggac ccgatctcca acacgctcat gccgggcgcg atttcggcct
    16621 gctcgatcat ttgcgcctgg atgtacgccg cgctggtgga ggagatgatc acgccgtctc
    16681 gatcgcgctt gatcgcgacc ggattgtcga cgttgtaggt ggcctccagc ggagtgccct
    16741 cggcgacgaa cagatgccag ggcacggtac ggaaagctcg ctccacccgt gacgaggtga
    16801 tcatgttgtc agcaaggagc ttgtccacca gtgcatcgcg gaactcggtg acgctggcgt
    16861 cgtcatgtcg gagagtgttc acctgactac tctttcagaa ggttgttctc gatggtgggc
    16921 cggttcaacg tcggtggacg aggggcgcgc cgtgcttggg gtcgcggcgc gccctggtca
    16981 ggaggcctcc agcatcgcgg cggtcgaccg accggcgaca gccgcatgct tgccggttcg
    17041 gtgcacggga ggaccgtcgg cggcgatcag gtgctggtga gcggtggtcc acaccgagca
    17101 gggatggggg cgaggccggc gccatcccga acactccggg taccgaccct ggtggtccgg
    17161 ccggtgggcg tccagcagag tccgccatgc cgcggtaagc ctgacgattt cggtatcggc
    17221 caacgcggcg cgagaccgca ggtctgcgtc ggtggccagc ttgtccaggt agtccagccg
    17281 gtcgtgaacc gcacggcgca acgcgtcggc caggaattca tccatggtca gccccttgaa
    17341 cgaggcgcag atcgttcaag atctgcacac agaactcgca gcgctcgaag gtggtgtgct
    17401 cagcagggtc cagcagttca cctgtggtcc aggcccgaca caccgcgagg ttgacgatct
    17461 tgcccagcgc gttcgccaca cggggtagac cgtcttgggt ctcctggacg tgtattcgct
    17521 gcggccgaac gactcctcgc tgccaccgcg ccacaaacgt cgttgtcatg ccgatccccc
    17581 agccagttgg gcgagcaccc ggcgcgtcgc accgactaca gccgaccagg gcggcaacgg
    17641 ccgccgaccg agcggcatcc gtgtccagcg ccaggcggcg ccgttcatgt cggtgaggtg
    17701 cgtcggcacc cgaacgtggt cgccgcgcgc caccgcgcag accccggctg cgaccacgtc
    17761 gtgcggcaca ctcggttgct cggcagcaga ccgatcggtc agcaacgtcc accacgcgct
    17821 gttcggggtc gcgatcgcgg gtccggccag caacatcacg tccaacgcgg cgtgcacgcg
    17881 ccgtgccagt ggcgcgggca tggtcagcgc gtcgatggtc tgcccggcgg acagcgccag
    17941 acatcgcgcc gtgacatcga cgcggactga ccaaccgagg tgttcctcat actgggcgca
    18001 ggcgtccacg agttcacgta gccatgccgg agccgccttc gtaccggttg ggctagctac
    18061 tgccggagtc atagccgacc tccacatcaa ggttgtcccg acgctggcaa gaggcgcagc
    18121 gccgctactg acgacgcggt caccaacttg tcgacggacg cgatcgtggc tgggcaggcg
    18181 ggggaccgag gacagtccgg ctaacactca acacacgatc caacggtggt tccgtctcgc
    18241 gcgatagggg cacatacgtg agcaatgcac aaggttcggg gaatcagcca gcaggtcgac
    18301 gaggcaaagt tcaaactcct gcgttggcgt tcaacttcct gccggtcaag ttcaccgacg
    18361 cctccttcga tgcgggcacg cagtcataca agtcgcctga gcaattggac gcacttcgag
    18421 cccggctagc caagtcgcac agcgtgatcc ggcttcgcag tcagatcgtt tgtgtgccga
    18481 taacgcgaga cgcagaggtc gtgggcgagc cgacgaggtt cgacacacgt gggccgaatc
    18541 tcgcattgac agcgtatctg ctgcaaggct gacgcgggtg ctgaccgaga ggtggaaatt
    18601 ctcgctgcgc aggttcgacc cgctcacctt cgtgtcgagg ctccccaatc gcgatctgat
    18661 gcagaaggcg ctgaaggacc gccacccgat cgagggcttg catgtgtacc cggagtacga
    18721 gctcgacgtg cgtcgctcag gcccgatggg gtacgccggg atcatcgttg gtctcaagac
    18781 acggtacgag atctcgttgc ccgtcagtga gctcatcgag ctcggtgtac acatggtggg
    18841 ccagtacgtg ctgaccgaaa cagactctgt ccctgagcgg ccgttccagg acccgatcgc
    18901 ccggcgccgg ctggccgggg ttgtcgaagc cgtagaccag gaccgcgtcg tactcggcac
    18961 ttcggacggg cgtatcgagg tacccgcgtc gcaggcatgg ttggaatcac gccgcgacaa
    19021 cttcctggcc gtggtcgaag cggtcgcggg agcgtctgcc acaagcatca ccgatgcgct
    19081 ggaataccag gtgttcactg tgaccggcgc tgagggccgg atggcgcgca ctcaggagat
    19141 cgccgacggc ctgatcaaac tcggcccact cactatcgcc aacgacatcc aagcgacgat
    19201 cgggaatggg gtgaagatca ccgcgccttc ggatcgcaag acacactggc ggctacccga
    19261 gccgacctac gttttcgacc tcggcggcga caagacacac ccgttccccg atccagggct
    19321 gaaccagttc gggccgttcg actctgaagg gttcacgccg aaaatcccac gcatcgccgt
    19381 ggtcaccccc aagcagcacc aaggcgccgt tgagggtttc atgagcagtt tccgtaatgg
    19441 cgtccgcggc gcatcagcgt tttcccaagg attcgtccgc aagtaccagc taaccgactg
    19501 tgccctcgtc ttcaccccct ttgacggcga tgtgtgtgac gctgccgcgt accggcaggc
    19561 gtgtcgaaac gccctggagg gcgacgaacc cccggatcga gccacgagag catggagaag
    19621 ctccagcatc tggagaagag cgtcgtggtg ctggtggagt ggatctccgg tgagatggag
    19681 ggctgggcca agctcaacgc ggcgtacaac gtcgtgaccg acgaggtcat ggacgccggg
    19741 ctctccgaga aggcgatcaa ggcgctcgag gccatcgtgt tagagggcta caagggctgg
    19801 accgacgcca tctgctcgga tcgttcgtgg tcatcttgag acgctccgtg cggtcggcgc
    19861 gtagcaccgg gagatggtgc tggcccacgc ccgtcaggcg atgcacgaga cgagcagtca
    19921 gcggctcgcg acgatcctgg acagattcga agcggagacg gtcgatcctc cgacgagtcc
    19981 gcgcagactg gcgctgtaaa gccgattggc agcaggcgta gcaggacgtc cctacgattc
    20041 tcttgtccct agtacctcga tatcctggag cggatcgact gtcgtgatca ctcagcagac
    20101 cttcatcatc ccgcccgaga tcgaggcggg cctgctcaat ggtgacctca aactctgggg
    20161 cggcgtggtg cgcaacctgt ctgggaagat cgtgaagcac ctcgaggaag tgaaggtgcc
    20221 tgcgcaggct ggcgagagcg cggcggtcag tactgcctcc agcaacgtga ggagctggtc
    20281 aggccttgct ggggacctca agaacccctg gttgatcatc ccggcagcgg ttgtgggcac
    20341 gctggctgca ggatcagctg tctacgtcgc ggtgaagaag caccggcagg ctgccacggc
    20401 cgaggtgccg gaggtcgtcg cgagctacaa cacctcgctg cgggggtacc tggaggcggt
    20461 ccgagaggga cggttgagcg aggagatcat cgggaagctc atctcggatc tcgacgccgt
    20521 cgtggcatac gaggagggcg ggacgatctc tctggacttc tcgtcgaagc acgtggagac
    20581 gttggtgggc atcgtggtgg acgccacgaa gcagcttgtc gaagcgaacg acctcgattt
    20641 ggatgagctc caggagcagg tgccggccga ggatgacaac gtggttgacc tgcgtcggta
    20701 cttggaggtc cagaaaagga tcttcaagga cgccgggtag tcagggtctg ctgaacagcg
    20761 attgtcgctc cagcgttcgg cagcgatcca agttttaccg tgactgaatt ccggcccaaa
    20821 ccggctgcgg cagcgccagc ggtcggacac ttgatcgaga ccccgtcgct ggggactgct
    20881 gacccaggac gctgacttgg atgccggtta agttgaggac aaacggaaat gccgggcctt
    20941 gcctcacggt catcggcagg accgcgcgtt cgggttaggt gccggaggcc atgtaggcgg
    21001 cgaggatgta gttggggtgt cggtccaggt tggtgcgggc ccggtcgtag cgcatggtgg
    21061 ttctggggtc ggcgtggcgc gcggcgatct ggacgtcgcg gaggtcgacg cccgcgtcga
    21121 gaatggtggt gacgaaggtg tggcggagca tgtggggatg catccgcggc agccgcacga
    21181 tcgagaccgc ggccaggtgg cggagcctgc gggtggcgca gtggcgatcc atccgtgctg
    21241 ctcgccggtt gagcaggatc gctccactgg ttctgtcgtg gacagctcgg tcgagagcgc
    21301 gcccgacggc gggcgggagc ggcacgagag tgaccttggt gcccttgccg atcacgcgta
    21361 ggacccggtg gccgtgttcc tctccgatgt cggtgatgtc ggagccgcag gcttcgaaga
    21421 tccgtaaccc gagtaagccg agcatcgcga ccagggcgaa gtcgaaccgg ttgctggagt
    21481 cgcgggctgc ggtgagcagg gcctcgaact gcaggtgtga caagcccagg gtgggtgact
    21541 cgttcgcgac gacgggtcgg cggacatagt cggcgggtga gtgttcgagg acggagtcga
    21601 tgacgcaggt gcggtagaag ccagcgacca cggccatcct tcgcgagacc gtggatggct
    21661 tgaaccggcg gatctcttgc atccaccgca cgtaccgttc cacgtccgca cgcaccatgc
    21721 ccagcggcgc aaattggcgt gcggcacacc aggccaggta gatccgcagg tcggactcgg
    21781 tatgcacccg cgagctgcca gtgaaccggg ccaggtaggc cgcgcacgcc aaccgcaaga
    21841 cgacgtcact gtcgggaagt acttcagaag cagtcatgcc gacgacggtg aacccggcgc
    21901 gaccgcccag cgaccccgcc gcggcatgag agtgcgttgg cattcgtctc atgggttgga
    21961 tggttaatta gtagctttgc gtatgtagct ggtgccgtga cccatcgacc tcgcgcggta
    22021 gaacgacgat gtctgcgggg tggcctggac ggatcaccgc gcactggcgc ggatggagca
    22081 agcctggagc acgtcgtggt gttgaaccgg gctgatcggt gtcgaacggc gccaaggttg
    22141 ctgacaacgt cttgccgtga tcacgcgatt ctctgtttcc actggtcaga gcgggtgact
    22201 accccggctg gcggtgtaac tgctgtcagt cggggtccca ccctttggta ttccggcccg
    22261 cgatgtgaac ctgtaaccca actcgtcggc ggtcacatgc agaaactgca agatcgagag
    22321 ggcttctaga aaagtggacc tgatggactc gaaaccctga tcctcacact gccaaagcca
    22381 gccattgtcg ccctgatccg actggaggta aagaagaagc taccgccgag aaggcgggat
    22441 accgcagtcg tcgattagcc ggcgctggtg gttggcggtc gttgcggcaa agtccatttc
    22501 gtcgttcggg cgccgacggc gatagaacca ctccggcacc cgggtagggt ccaccctagt
    22561 gcgcaagatg ccgtcctgca catcccgggc cacctcgcac agccgccgct gttcgacgtc
    22621 atcgagcgaa ccgggccgcg cggcccgcaa ctcgcttgtg acgattcgaa ctagccgctc
    22681 acgttcggcg gcaacgcgct gttgcgcggc ccagatctcg cagacgagct gataagcaga
    22741 cagcgacggc acgtagaagc cgagcagtac ctcggtgagc gtggtgcctg acaccaagat
    22801 gcccgtgacc gcgccgagca ggctccaaca cgccgccgcg gtcagtagca cggcggcgta
    22861 gcgtcgtctc aagcgagcat cccaggccag gttctgttcc tgcgccatca gcacgtcgta
    22921 cggatggtgc actcctccgg tagggtcgta ccagccttcg gcgatccgat tgtccttcgc
    22981 gcagcccgac ttcagtcgcc gagccagccg atgaacttcg gcctccggga tcgggtcacc
    23041 agccaccatg gttcgccagg gcagccggaa caggctggtg tcgaacatct cttgcagcag
    23101 cgccccctgc agcgcgatag cagccgcggc ccgtctgagt ggaaaggccg ataccaggaa
    23161 ccaggcgaaa ccgatgatcg ccattgcctg ccgcccaggc ccagccaggg tgacgaccac
    23221 gccagcggcg gccagcagcc ctgcagcggt ggtacggacc gcttccactg cctgcccccg
    23281 ctgatgactg gcagcagccg cgcgctgcag ccgcaccatg tcgccgtcaa gttgccgctg
    23341 gtcgattgag cgcggtgtcg tcatcagaag gtctcattgc tggtcggcgc gatccggaac
    23401 ccgtggctgt cgcgggtgca gcggaaaccg tcgggttccg cggcgcaggt gaaaccgagc
    23461 gcggtgatgg tcttgccagg tggcaacaca tcgccgtcgt tcggctcacg tccaaccgga
    23521 tagaacatca cgccgcccgc gcacaagaaa tcgaccttgc cgtcggtgtc gacggacatt
    23581 ccggcgcccc agctaggccc gaccttttcg caggattcgg gccggggtgg cacgggcttg
    23641 gtagcgccct ggcacaaagc ttgcttcttg tcgataccgc acacatagga ccggtcggcc
    23701 gaggtgaaga agtagtacgg ttcatcgcca gaaccgctga gctgctgacg gtacttggcg
    23761 gtggtcgact gtccgaccca gtgtaccgac ccgtctttat ctaccgtgaa cacgatcgag
    23821 ccctggaccg gcgcggagta cctttccttg aagtccgtcg agtcgaagtc agtggtcagg
    23881 ccgagcaagc cgatgtcatg gagttgttcc cgggtgcagg tgccgtccgg gccacggcca
    23941 tcgacgcagc gcgactcggt caggccagga aacgtcagcg ccccggactc cagcactggg
    24001 tgagtacgca gggtgcgacg tagtttttcg cggccagacc gggttcggat cagagccagc
    24061 gtgtcggtgt cacaccgcgc gcacaacgcg gtcaacgtgc tctggtcttc accgtccaag
    24121 gcggtgatca gcttgcccat cagatcttga atctcttggg aaagcggctt tccgtggtcg
    24181 tcggtcctga tccgttcttc cgatggctgc gtctgcgcct ccggtctgcc cgctgcctgt
    24241 tccgcagggg tcagccacat tgtcgccact gtgtcggcaa gcgtgacagg agccttgtcc
    24301 ttccagttca gcgtgagtct gcctcgaacc tccgggtcct tggtcgcgtc gatgtcatcg
    24361 ccgatctcaa tggcgtaaga tcgtccggcg gctccgaatc ccaattggag tgcgcccgtg
    24421 cgtagcaagc gcatgcggcc gtcgtcgacc tggtagctga ggaaccgctc cgggaacagg
    24481 cggtggcact ccactccggg gccaaaggtg accacgaggc tggatccggc ccaggtctga
    24541 ccggtgaccc gtcgggcctc gatcagaacg gcttccgcga atgttgaatc tttgggaatc
    24601 aacgcttccg actttggatt cgttcccgtg ctgttgagca tcagcacact cgacgaggtt
    24661 cggcacgctc cgctgctcgg cgcctcgatc gtggcgacgc gcgtgccgtc gggcgaagtc
    24721 gacccacccc agaacgagac cgcggagtca ccctcgatca tcaaccgctc ctgccccttg
    24781 gcatccaccg cggtcagcgc gccctgccca cggtaggagg ctcgttcctc gggaatcggt
    24841 tcgaccacag cgacctgatc acggccaccc gcgccgaccc aggcgtacgg cattggcctg
    24901 cgcaatggca cacggctggg gttgccgtcc ctgtcgaaca caagcaacgc ggagccatcc
    24961 gcgctgacag tggcgaaccc ctcgccgaac cacccgagac cggcgcacgg acacggctgg
    25021 gacttctcga cgccagtggc agcggtcacg atgtggaggt tggtcttgtc gagccaggcg
    25081 aactgcttgc cgtcggctga ccaagtcgcc ggactgtacg gcgaggcgat cggtatcccg
    25141 ccccagacat gtccggcgcc gtcggcgaac cgcagttcgg cccctgacac gaaggcgacg
    25201 gtggcatcac cgcgcgcatc ggagtccgtc gttggctggg gcatgccgtc cgtgccgcag
    25261 gccgctatga gcacgcacag ggtcagtgtg agtagtcggg gagggatc
//
