LOCUS       NZ_LN850107            12127 bp    DNA     linear   CON 13-AUG-2024
DEFINITION  Alloactinosynnema sp. L-07 isolate Alloactinosynnema sp. L-07
            chromosome I.
ACCESSION   NZ_LN850107
VERSION     NZ_LN850107.1
KEYWORDS    RefSeq.
SOURCE      Alloactinosynnema sp. L-07
  ORGANISM  Alloactinosynnema sp. L-07
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae.
REFERENCE   1
  AUTHORS   Ramaraj,Thiru.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAY-2015) National Center for Genome Resources (NCGR),
            National Center for Genome Resources (NCGR), 2935 Rodeo Park Drive
            East, Santa Fe, New Mexico, 87505, USA
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_900070365.1-RS_2024_08_13
            Annotation Date                   :: 08/13/2024 03:00:54
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,999
            CDSs (total)                      :: 6,934
            Genes (coding)                    :: 6,831
            CDSs (with protein)               :: 6,831
            Genes (RNA)                       :: 65
            rRNAs                             :: 3, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 3, 3, 3 (5S, 16S, 23S)
            tRNAs                             :: 53
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 103
            CDSs (without protein)            :: 103
            Pseudo Genes (ambiguous residues) :: 0 of 103
            Pseudo Genes (frameshifted)       :: 30 of 103
            Pseudo Genes (incomplete)         :: 83 of 103
            Pseudo Genes (internal stop)      :: 1 of 103
            Pseudo Genes (multiple problems)  :: 11 of 103
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 08:22:15
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1254137
            Orig. end                         :: 1266264
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            LN850107.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..12127
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="10"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..12127
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..12127
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:7127](+)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..7127
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     misc_feature    58..73
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: weak, score: 15.8"
                     /tool="antismash"
     gene            complement(<943..1893)
                     /locus_tag="BN1701_RS33975"
                     /pseudo=""
     CDS             complement(<943..1893)
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:TIGR03083.1"
                     /locus_tag="BN1701_RS33975"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="maleylpyruvate isomerase family
                     mycothiol-dependent enzyme"
                     /pseudo=""
                     /transl_table=11
                     /translation="MLSRGRSRSTPRRLCSRAPRTTRRSATEIPSVVHVSRPGTGLTHE
                     RRSAKCEWPRVADPHARTGHRQFSRTRVRHAPAKRYRRVTTLAYSGWGEQLCSVRHQLS
                     IGVRMSGLNTSSHTTAGTLAAVKEATSVLTGVVDGFSESDFPRPSLLPGWTRGHVVTHL
                     ARNADALVNLLTWARTGIEHAAYPSRADRDAAIHAGATRLGQVQREDLIAASGRFLVEA
                     RRLTDADWAAPVQHPHGELIPAVEIPQRRLFEVWTHLVDLDAGFGFDAVPADHLDLMLD
                     RAVHPILSRTGGTPVRLRVDLPDGRQRSWEFAIGTQ"
     gene            1814..4666
                     /gene="uvrA"
                     /locus_tag="BN1701_RS06030"
     CDS             1814..4666
                     /EC_number="3.1.25.-"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_process="GO:0006289 - nucleotide-excision repair
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="uvrA"
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018686461.1"
                     /locus_tag="BN1701_RS06030"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="excinuclease ABC subunit UvrA"
                     /protein_id="WP_054046271.1"
                     /transl_table=11
                     /translation="MADRLVVRGAREHNLRGVDLDLPRDSMIVFTGLSGSGKSSLAFDT
                     IFAEGQRRYVESLSAYARQFLGQMDKPDVDFIEGLSPAVSIDQKSTSRNPRSTVGTITE
                     VYDYLRLLYARAGKPHCPTCGEAISKQTPQQIVDQVLAMESGLKFQVLAPIIRGRKGEY
                     LDLFSQLQTQGYSRALVDGVVHSLADPPKLKKQEKHDIAVIVDRLAVKATSKQRLTDSV
                     ETALRLADGLVELEFVDLPEHDPARIRGFSEHLACPNGHPLGVEDLEPRSFSFNSPYGA
                     CPVCTGIGVKKEVDPELVVPDDELSLGDGAIAPWAGGQTAEYFVRLLSALGESIGFRMD
                     TPWRRLPAKAQKAVLHGVPDQVHVRYQNRYGRERSYYAAYEGVIPFLERRQEQTDSEYM
                     REKYEGYMREVPCPSCQGTRLKPEILAVTLAHKDQGDRSIADVSNMSISECSAFLDGLT
                     LGKRETMIAGAVLKEIQARLRFLLDVGLDYLSLDRASGTLSGGEAQRIRLATQIGSGLV
                     GVLYVLDEPSIGLHQRDNHRLIETLTRLRDLGNTLIVVEHDEDTIRQSDWVVDIGPGAG
                     EHGGQVVHSGPFKELLKNKQSLTGAYLAGRSSIPMPMLRRSIDKKRQLTVVGAREHNLR
                     GIDVSFPLGCLVAVTGVSGSGKSTLVNDILATVLANKLNGARQVPGRHTRVRGLDMVDK
                     LVQVDQSPIGRTPRSNAATYTGVFDHVRKLFASTTEAKVRGYQPGRFSFNVKGGRCEAC
                     AGDGTIKIEMNFLPDVYVPCEVCKGARYNRETLEVHYKGKTIAEILDMPIEEAAAFFEP
                     IKAIHRHLATLVDVGLGYVRLGQPAPTLSGGEAQRVKLASELQKRSTGKTVYILDEPTT
                     GLHFEDIRKLLGVINGLVDKGNTVIVIEHNLDVIKTSDWIVDMGPEGGSGGGLVVAQGT
                     PEDVVKVEGSYTGEFLAHVM"
     misc_feature    complement(1815..1829)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.8"
                     /tool="antismash"
     gene            4754..5011
                     /locus_tag="BN1701_RS06035"
     CDS             4754..5011
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="BN1701_RS06035"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_054046273.1"
                     /transl_table=11
                     /translation="MPDTRDLEARVIKLQRNTAALLSLLGGDDDEKLRFWEILKGITTP
                     AEYKLVAHSLDVMQAQVDQVEFAARSIEATAKEMGRVRAG"
     gene            5001..7127
                     /locus_tag="BN1701_RS06040"
     CDS             5001..7127
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: YcaO"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF014661.4"
                     /locus_tag="BN1701_RS06040"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="YcaO-like family protein"
                     /protein_id="WP_054046275.1"
                     /sec_met_domain="YcaO (E-value: 5.3e-56, bitscore: 189.4,
                     seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRAEQAIQADRAPTRPDPALSLTTRLARESGDGVVVYAGSGRPVP
                     PAAKLAVFIADGDPSVTKFGRWARSARLPAVAVLFDGERALVGPLSTPGSPGCGACARS
                     RRIAAAAASRGTATPRVTHTTAPHSRPLPGLAVAVKTARAADPEETQVVRDDDPDRTTA
                     VPPGSMIPEDERTTRVTADEVKRIIADPERTVAVSDPDQTTTVAAEDIERTGSQGTVAG
                     FLDVSDPQLDKIIELLGDGGKELADHLAEVVDGEVLWHRVIPLPDCDVCGGADGLGTVG
                     LPTEDDPALLLESLAGWVDPLTGVIPWISLKQPLGTGPDLPFVATAAPPHRLDADGVPR
                     ALPIGWGKGATRCAAIVSAVGEAIERYAPSLPDGARIVWARPADLDGEVLDPREFPLYE
                     PQTYARAGFEFAAFDRRVDHPWVRGKWLGTDRSVWVPAVFTYLSMTLLPEHLISQGTSN
                     GLAAGTDAESATARAVLELVERDAMMAAWLTGAKGRYVDLDETLDVDLRAIVDALRVQG
                     PGVEVYLLPTSTYGVTAVALSLGDGRRWPGVTLGLGADRSPRAAIRAALMELAQTAPHL
                     ATLLRDRAHPVPKHAEDVRNMLDHAAYYFPANRVEAFDRIRCGGTSRLRDLVEPVPETS
                     VPDLAGVLGEAGIRVAIVDVTSADVAMGPFRVVRAVSPDLQPISYGFGNDRSPVARLRD
                     KLLPPHRRQVHPIW"
     gene            7179..8423
                     /locus_tag="BN1701_RS06045"
     CDS             7179..8423
                     /GO_function="GO:0016158 - 3-phytase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018686458.1"
                     /locus_tag="BN1701_RS06045"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="phytase"
                     /protein_id="WP_054046277.1"
                     /transl_table=11
                     /translation="MRLTKVLAVVLATGAVLSVAVAPASADLPGVTATYETASNYDDEA
                     GGDADADDPAIWVNPTRPGASVVVGTLKNGGLTVVDLRGRELQHIATGEGGRFNNVDIV
                     AGARIGGRTLDLAVVSDRGLDRLRIYAIDPRGAGAGAHVLTDVTTATPPRVFSATEAEI
                     EEQRTAYGIAVRPDPAGGAPWVVASRRHETRVGLFRLAGDGAGRITYRQVDTVDLPAAF
                     AVDGGTWAPCAEPGERPQVEGMVVDGDVVYAAQEDVGIWRIPLRWGLGRPELVQRVREF
                     GRPAVFDEVTEECVFTGPESPSAGKYLTADAEGLTVAHTRFGKVLLASSQGDNTFAAFT
                     PTRTGLVYRNGFTVGDGVLDGVRHSDGAAVTTKSLGPEFPHGLLVVHDGENTPSDRPDT
                     NFKLVRWERVASVLG"
     misc_feature    complement(7185..7200)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 17.55"
                     /tool="antismash"
     misc_feature    7197..7199
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    8436..8451
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 20.72"
                     /tool="antismash"
     gene            8512..9378
                     /locus_tag="BN1701_RS06050"
     CDS             8512..9378
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020667090.1"
                     /locus_tag="BN1701_RS06050"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_054046280.1"
                     /transl_table=11
                     /translation="MNRIRVTAFAASAVIGVFALSACTAGQQTAGAPVAAPEVLAKVTL
                     AAADIEGLGAVVTDVEGRTLYRFDKDKAKPPTSTCDGECAVAWPPALAGDTDIAADGVD
                     EELIGTLERGDGTRQLTLNGWPLYRFAKDKAVGEAKGQGVGGTWFAATPEGKKAVAEVE
                     KDAVRLTAKEIADLGTGVVDAKGYTLYRFDKDKAKPSKSSCDGDCAKAWPPVLAKDSVD
                     IEGIDEAIVGTVVRADGSRQLTLNGWPLYRFAKDTAPGEAKGHGVGGTWFATTPAGKKA
                     AAAASGY"
     gene            9456..10007
                     /locus_tag="BN1701_RS06055"
     CDS             9456..10007
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0016987 - sigma factor activity [Evidence
                     IEA]"
                     /GO_process="GO:0006352 - DNA-templated transcription
                     initiation [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1032: RNA
                     polymerase, sigma-24 subunit, ECF subfamily"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005159188.1"
                     /locus_tag="BN1701_RS06055"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="sigma-70 family RNA polymerase sigma factor"
                     /protein_id="WP_054046282.1"
                     /transl_table=11
                     /translation="MTIPGFRPRRRKQVPGEDFVRFLYGEHGKALLAYTTRLTGDRAAA
                     EDIVQETLLRAWKHADTLADESRGSTRGWLLTVARNIVTDRVRARAARPQEVGEPLDAP
                     GADSDHADSVVNEMAVLGALDHLSREHRDVLVEVYYRGRSVAEAAQALGIPAGTVKSRT
                     YHALRALRGVMGPGEREVTR"
     misc_feature    9954..9956
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            10004..10684
                     /locus_tag="BN1701_RS06060"
     CDS             10004..10684
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005159187.1"
                     /locus_tag="BN1701_RS06060"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="anti-sigma factor"
                     /protein_id="WP_054046284.1"
                     /transl_table=11
                     /translation="MTAFQHDREQLGAFALGVLDQREADQVRAHLAQCPDCRHEVDDLL
                     ALRRSLDEIPPEAFLEGPPDSDLVLQRTLRKMSSESAPRRGLVAAGVAVLAAVALGGAF
                     FAGRTTAPEPVAAPPPTTVPGTRAGAATDPDTGAVMSVKLVPQAGWVRVNAMVKGAPVG
                     ARCELRVVSKSGGESVLAGSWLVSEKGARDGTSLDGSALIDPDDVAAVEVVTTDGRRIV
                     SASV"
     gene            complement(10601..11944)
                     /locus_tag="BN1701_RS06065"
     CDS             complement(10601..11944)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="BN1701_RS06065"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_054046285.1"
                     /transl_table=11
                     /translation="MTSTEPRQSHAGLAAVALLVLPAVALLLLMPAPIGMTGLNPPWFV
                     HAAAPVAALVGVAAAWAWPHVGWRWVLLAASMCWLGAGIAEPYTSVVLALSSAAGLLTL
                     AGGLGAAAWIGRSGAWALGAAVAGTVLGAYVVASAVRWVELLYIAPGQPLLPVVAGVGI
                     LVSAVLVGLSRRAAPEPRPAVPVLIASIVASLVPVAFAVTDQVGLPLIQVGGEGIADWV
                     RARGIVGLVAALAVIGVSAIAGARFVAGVVVVGGLVSASAVLTTFIEFDNTPILGSRPV
                     ETVLVYPGVTLSVWLLMTLGLALGVAAALPFRRQVVASVGVAISAVVVYLGITQAVDER
                     LWVRAAVVALVFAVVAGAGAIGAGAATGVVGVMLGLAVPQTALLWQPRFPEPIAVIHRY
                     PFWTPVLSLAAAAVGLAVLAWLYRGRDDAPAVGGDDLDRGDVVGVDQG"
ORIGIN
        1 cgccgtggtc ggcacctatc tcgtgacgag ggccgtggcg cccgcgttcg ggtggtatgt
       61 gcccgatgtc acggacctgg tcgccaacct gctgctcatc caggcgtggt caccggagtt
      121 ccactgggtc gacgcgtcct actggacttt cccgttgcag gtcatggcgt tcatcgccgc
      181 ggccctactc tggccgacgc ggtggcgccg cgggaccgcg ctgactggtc tgttgtggac
      241 actggtcctg ctgccgctgg tcatccggtt cgcgttccgg cacgacgacg cgcagcagtg
      301 gatcaagtcg gtgttcgacg ggctggcgct gcaccgggtc gcgctgttcg gggtcggcgt
      361 ggcgatctgg ctgtggacgc ggaaccgcat gtccgcgcgg caccttggcc tctacgtgac
      421 cgccgccctg gtcgcccagg acgcgcactc ctacttcgtg gacacctggt cgaccatcgc
      481 gttcggcgtg atcgtcgtgg gcatcatcgc cgccgcgggc gggccggact gggacatccc
      541 gggcatccgg cagctcgcgc ggccgatccg gtggctgggt ggcatctcct tcggcgtcta
      601 cctggtccac caggaactcg ggttcgtgct ggcccgcttc ctgctcgacg ccggggtcgg
      661 gccttggggg cggctggccg tttgcgtggc catggcgatc ctgctcggct gggcgatgac
      721 caggctggtc gagcagcctg cccaccgcct gctgaccggc gacgtctggc accgcgcccg
      781 ggcagcggcg agcacggtgg cggcggcggt gcgggagctc ccgcaggtgc ctcagcccca
      841 ggcggctagt tccggtgggg tcccgtcgag ttcgaccggg ccgcggccgg tgagccaggc
      901 cagcgcggcc gcggccgatc cgctcaactc ggtgccgccg tcctgggtgc cgatggcgaa
      961 ctcccagctg cgctgacggc cgtcgggcag gtcgacccgc agccgcaccg gcgtgccccc
     1021 ggtccggctc aggatcgggt gcacggcccg gtcgagcatg aggtcgaggt ggtcggcggg
     1081 caccgcgtcg aacccgaatc ccgcgtcgag gtcgactagg tgggtccaca cctcgaacag
     1141 cctgcgctgc gggatctcga cggccgggat cagctcgccg tgcgggtgct gcaccggcgc
     1201 ggcccagtcc gcgtcggtca gtctgcgggc ctcgaccagg aagcggccgg acgcggcgat
     1261 caggtcctcg cgctggacct ggccgagcct ggtcgcgccc gcgtggatgg ccgcgtcgcg
     1321 gtcggcgcgg ctggggtagg cggcgtgctc gatgccggtg cgggcccacg tgagcaggtt
     1381 gaccagcgca tcggcgtttc gggccaggtg ggtgaccacg tggccgcggg tccaccccgg
     1441 cagcaggctg ggtctgggga agtcggactc gctgaatccg tcgaccaccc cggtcaggac
     1501 ggaggttgcc tccttgaccg cggcgagcgt gcccgcggtg gtgtgcgagg acgtgttcaa
     1561 cccactcatg cgcaccccga tgctgagttg gtggcgaacg gagcaaagtt gctctcccca
     1621 tccagagtag gcgagggttg ttacccgtcg gtaccgcttc gcgggtgcat gacgaacccg
     1681 ggtccgcgag aattgtcggt gccccgtgcg agcatggggg tcggccaccc gtggccactc
     1741 acactttgct gatcgacgtt catgggtcag acccgtgccc ggtcggctca cgtgcactac
     1801 cgaagggatt tcagtggccg accgcctcgt cgttcgcggc gcccgtgagc acaacctgcg
     1861 cggcgtcgac ctcgaccttc cccgcgacag catgatcgtg ttcaccggcc tgtccgggtc
     1921 cggcaagtcc agcctggcgt tcgacacgat cttcgccgag gggcagcgcc gctacgtcga
     1981 gtcgctgtcg gcctacgcgc gccagttcct cggccagatg gacaagcccg acgtcgactt
     2041 catcgagggc ctctcgcccg cggtctcgat cgaccagaag tcgaccagcc gcaacccgcg
     2101 ctcgaccgtg ggcacgatca ccgaggtcta cgactacctg cgcctgctct acgcgcgcgc
     2161 gggcaagccg cactgcccga cctgcggcga ggcgatcagc aagcagaccc cgcagcagat
     2221 cgtcgaccag gtgctggcca tggagtccgg cctgaagttc caggtgctcg ccccgatcat
     2281 ccgcggccgc aagggcgaat acctcgacct gttctcccag ctccagaccc agggctattc
     2341 gcgcgcgctg gtcgacggcg tggtccacag cctggccgac ccgccgaagc tcaagaagca
     2401 ggagaagcac gacatcgcgg tcatcgtcga ccggctcgcg gtgaaggcga cgtccaagca
     2461 gcggctcacc gactcggtcg agaccgcgct gcgcctggcc gacgggctcg tcgagttgga
     2521 gttcgtcgac ctgcccgagc atgatccagc ccgtattcgc ggcttctccg agcacttggc
     2581 gtgccccaac ggccacccgc tcggcgtcga ggacctggag ccgcgctcgt tctccttcaa
     2641 ctcgccctac ggcgcgtgtc cggtgtgcac gggcatcggc gtcaagaagg aggtcgaccc
     2701 ggagctggtc gtgcccgacg acgagctgtc gctgggcgac ggcgccatcg cgccgtgggc
     2761 cggtggccag accgccgagt acttcgtccg gctgctctcg gcgctggggg agtcgatcgg
     2821 gttccggatg gacaccccgt ggcggcggct gcccgccaag gcgcagaagg cggtcctgca
     2881 cggcgtgccc gaccaggtgc acgtccgcta ccagaaccgc tacggccgcg aacgctccta
     2941 ctacgccgcc tacgaaggtg tgatcccgtt cctcgaacgg cgccaggagc agaccgactc
     3001 cgagtacatg cgcgagaagt acgagggcta catgcgcgag gtcccgtgcc cctcgtgcca
     3061 gggcacccgc ctcaagcccg agatcctggc cgtcacgctc gcgcacaagg accagggcga
     3121 ccgctccatc gccgacgtct ccaacatgtc gatcagcgag tgctctgcct tcctcgacgg
     3181 actcaccctg ggcaagcgcg agacgatgat cgcgggcgcc gtcctcaagg agatccaggc
     3241 ccgcctgcgg ttcctactgg acgtcggcct ggactatctg tccctggacc gcgcgtccgg
     3301 cacgctgtcc ggcggcgagg cgcagcgcat ccggttggcc acgcagatcg gctccggcct
     3361 ggtcggcgtg ctgtatgtcc tggacgagcc gtcgatcggg ctgcaccagc gcgacaacca
     3421 ccggctgatc gagaccctga ccaggctgcg cgacctgggc aacacgctga tcgtggtgga
     3481 gcacgacgag gacaccatcc gccagtccga ctgggtggtc gacatcggcc ccggcgcggg
     3541 cgagcacggc ggccaggtcg tgcacagcgg cccgttcaag gaactgctga agaacaagca
     3601 gtcgctgacc ggcgcctacc tcgcgggccg cagcagcatc ccgatgccga tgctgcgccg
     3661 ctcgatcgac aagaagcgcc agctcaccgt cgtcggagcg cgggagcaca acctgcgcgg
     3721 catcgacgtc tccttcccgc tgggctgcct ggtcgcggtg accggcgtgt ccggctcggg
     3781 aaagtccacc ctggtcaacg acatcctcgc caccgtcctg gcgaacaagc tcaacggcgc
     3841 gcgccaggtg cccgggcggc acacacgggt ccgcggcctg gacatggtcg acaagctcgt
     3901 ccaggtcgac cagtcgccca tcggccgcac cccgcgctcc aacgccgcga cctacaccgg
     3961 cgtgttcgac cacgtccgca agctgttcgc ctcgaccacc gaggccaagg tccgcggcta
     4021 ccagccgggc cggttctcct tcaacgtcaa gggcggccgc tgcgaggcgt gcgcgggcga
     4081 cggcacgatc aagatcgaga tgaacttcct gccggacgtg tacgtgccgt gcgaggtctg
     4141 caagggcgcg cgctacaacc gggagaccct ggaggtccac tacaagggca agacgatcgc
     4201 cgagatcctc gacatgccga tcgaggaggc cgccgcgttc ttcgagccga tcaaggccat
     4261 ccaccggcac ctggccaccc tggtcgacgt cggcctcggc tacgtccggt tgggacagcc
     4321 cgcgccgacg ctgtccggcg gcgaggccca gcgggtcaag ctcgccagcg agttgcagaa
     4381 gcgctcgacc ggcaagacgg tctacattct cgacgagccg accaccggcc tgcacttcga
     4441 ggacatccgc aagctgctcg gcgtgatcaa cggcctggtg gacaagggaa acacggtgat
     4501 cgtgatcgag cacaacctcg acgtgatcaa gacctcggac tggatcgtcg acatgggacc
     4561 ggagggcgga tcgggcggcg gcctggtcgt ggcacagggc acgccggagg acgtggtcaa
     4621 ggtcgagggc agctacaccg gagagtttct cgcccacgtg atgtgacctg cgatgattcg
     4681 ggtggagaat gtatccctcg attggttgcc gactccttcc tcatgaccga ggtaggcaat
     4741 cagggaggcc gccatgccag acaccaggga tctcgaagcc agagtgatca agctccagcg
     4801 caacaccgcc gcgctgctgt cgctgctcgg cggcgatgac gacgagaagc tgcgcttctg
     4861 ggagatcctc aaagggatca ccaccccggc ggagtacaag ctcgtcgcgc acagcctcga
     4921 cgtgatgcag gcgcaggtcg accaggtcga gttcgcggcc cgctccattg aggccacggc
     4981 caaggagatg gggcgggtgc gtgcgggctg agcaggccat ccaggcggac cgggccccga
     5041 cccgaccgga ccccgcgctg tcactgacca cgcgcctggc gcgcgagtcc ggtgacggcg
     5101 tggtggtcta tgccggatcc ggccgcccgg tgccgcccgc ggccaagctc gccgtgttca
     5161 tcgcagacgg cgacccctcg gtcacgaagt tcgggcggtg ggcgcggtcc gcgcggctgc
     5221 ccgcggtcgc ggtgctgttc gacggtgagc gcgctctggt cgggccgctg tcgacgccgg
     5281 ggagtccggg gtgcggcgcc tgcgcccgca gccgccggat cgcggccgcc gcggcgtcgc
     5341 ggggaaccgc caccccacgc gtgacccaca ccaccgcccc acactcccgc ccgctgcccg
     5401 gcctcgccgt cgcggtcaag accgcccgcg cggccgatcc cgaggagacc caggtcgtcc
     5461 gcgacgacga cccggaccgc accaccgcgg tcccgccggg ttcgatgatc cctgaggacg
     5521 aacgcaccac gcgggtgacc gcggacgagg tcaagcggat catcgcggac ccggagcgca
     5581 ccgtcgcggt gtccgatccg gaccagacca ccaccgtcgc cgcggaggac atcgaacgca
     5641 ccggcagcca gggcacggtc gcgggtttcc tcgacgtcag cgatcctcaa cttgacaaga
     5701 tcatcgaact gctgggcgac ggcggcaagg aactggccga ccacctcgcc gaggtcgtcg
     5761 acggcgaagt gctgtggcac cgggtgatcc cgctgcccga ctgcgacgtc tgcggcggcg
     5821 ccgacgggct gggcaccgtt ggcctgccca ccgaagacga cccggccctg ctgctggagt
     5881 cgctggcggg ctgggtcgac ccgctgaccg gcgtgatccc gtggatctcg ctcaagcagc
     5941 cgctgggcac cgggcccgac ctgccgttcg tcgcgaccgc cgcaccgccg caccgcctcg
     6001 acgccgacgg cgtcccgcgc gcgctgccga tcggctgggg caagggcgcc acccgctgcg
     6061 ccgccatcgt ctcggcggtg ggggaggcga tcgagcggta cgcgccgtcg ctgcccgatg
     6121 gcgcccggat cgtctgggcc cggcccgccg acctcgacgg cgaggtgctc gacccgcgtg
     6181 agttcccgct gtacgagccg cagacctatg cgcgcgcggg cttcgagttc gccgcgttcg
     6241 accgccgcgt cgaccatccg tgggtccggg gcaagtggct gggcaccgac cggtcggtgt
     6301 gggtcccggc ggtcttcacc tacctgtcga tgacgctgct gcccgagcac ctgatcagcc
     6361 agggcacgtc caacggcttg gcggcgggca ccgacgccga gtccgccacc gcccgcgcgg
     6421 tcctggaact ggtcgagcgc gacgcgatga tggccgcctg gctcaccggt gccaaaggcc
     6481 gctatgtcga cctggacgag accctcgacg tcgaccttcg cgccatcgtg gacgccttgc
     6541 gtgtccaggg gcccggcgtc gaggtctatc tgctgccgac cagcacgtac ggggtcaccg
     6601 cggttgcttt gtcgctgggt gacggtcgcc gctggcccgg tgtgacgctt ggcttgggcg
     6661 ccgaccgttc gccccgggcc gcgatccggg ccgcgctgat ggaactcgcc cagaccgcgc
     6721 cgcacctggc gaccctgctg cgcgaccggg cccaccccgt gcccaagcac gccgaggacg
     6781 tgcggaacat gctcgaccac gccgcctact acttccccgc caaccgcgtc gaggccttcg
     6841 accgcattcg ctgcggcggc acctcccgcc tgcgtgatct cgtcgagccg gtgccggaga
     6901 cgtcggtccc cgacctggcg ggcgtcctgg gtgaggccgg gattcgggtc gcgatcgtgg
     6961 acgtgaccag cgcggacgtg gcgatgggcc cgttccgggt ggtgcgggcg gtgagtccgg
     7021 acctgcagcc gatcagctat ggcttcggca acgaccgctc gccggtggcc cgactgcggg
     7081 acaagctgtt gccgccgcat cgcaggcagg tccacccgat ctggtgagtt cacccagcgt
     7141 ccagcctgtg gtcaccagcg ctgggaaggc tcacgcccat gcgattgaca aaggtgttag
     7201 cggtggtcct ggccacgggt gcggtgctgt cggtggcggt cgccccggcg tcggccgacc
     7261 tccccggcgt gaccgccacg tatgagacag cgtccaacta cgacgacgag gcgggcggcg
     7321 acgccgacgc cgacgacccc gcgatctggg tcaacccgac ccggcccggt gccagcgtcg
     7381 tcgtcggcac cctgaagaac ggcggtctga ccgtcgtcga tctgcggggc cgcgaactgc
     7441 agcacatcgc caccggtgag ggcggccggt tcaacaatgt cgacatcgtc gcgggtgccc
     7501 ggatcggcgg ccgcacgctc gacctggccg tggtgtccga ccgcggtctc gaccggctgc
     7561 ggatctacgc catcgacccg cgcggcgcgg gtgcgggtgc gcacgtcctg accgacgtca
     7621 ccacggccac cccgccgagg gtgttcagcg cgaccgaggc ggagatcgag gagcagcgca
     7681 ccgcctatgg catcgcggtc cggccggacc cggcgggcgg ggcgccgtgg gtggtggcca
     7741 gccgcaggca cgagaccagg gtcggcctgt tccgtttggc aggcgacggc gcgggccgga
     7801 tcacctaccg gcaggtcgac acggtcgact tgcccgccgc cttcgccgtg gacggcggga
     7861 cgtgggcgcc gtgcgccgag ccgggggagc gaccccaggt cgagggcatg gtcgtcgacg
     7921 gtgacgtcgt ctacgccgcg caggaggacg tgggcatctg gcggatcccg ctgcgctggg
     7981 gcctcggccg cccggaactg gtgcagcgcg tgcgcgagtt cggcaggccc gcggtgttcg
     8041 acgaggtcac cgaggagtgc gtgttcaccg ggcccgagtc gccgtcggct ggcaagtacc
     8101 tgacggccga cgcggagggg ctgaccgtcg cccacacccg gttcggcaag gtcctgctgg
     8161 cctccagcca gggtgacaac acgttcgcgg cgttcacccc gacgcgcacg ggtctggtgt
     8221 accgcaacgg gttcaccgtc ggggacggtg tgctcgacgg cgtgcggcac agcgacggtg
     8281 ccgcggtgac gacgaagtcg ctcggccccg agttcccgca cggactgctg gtcgtgcacg
     8341 acggcgagaa cacgccgtcg gaccgccccg acaccaactt caagctggtc cggtgggagc
     8401 gagtggcctc ggttctcggt tagcctcaag aaatcttgac catctcgtga accggcgcgg
     8461 gtgcgggtcc gtgtgtgtga tgtcgaagca cacagcccag gaggtcaccg catgaaccgc
     8521 atccgcgtca ccgcgttcgc cgcttccgcc gtcatcggcg tgttcgccct gtcggcgtgc
     8581 accgctgggc agcagaccgc aggcgcgccc gtcgcggcgc cggaagtcct cgccaaggtc
     8641 acgctcgccg cggctgatat cgaggggctg ggcgcggttg tcacagatgt cgaagggcgc
     8701 acgctttacc ggttcgacaa ggataaagcc aaaccgccta cgtccacttg cgacggtgag
     8761 tgcgccgtgg cgtggccgcc cgcgctggcg ggcgacaccg atatcgccgc cgacggggtc
     8821 gacgaggagc tcatcgggac gctggagcgc ggcgacggca ccaggcagct gaccctcaac
     8881 ggctggccgc tctaccgctt cgccaaggac aaggcggtgg gcgaggccaa ggggcagggc
     8941 gtgggtggca cctggttcgc cgcgacgccc gagggcaaga aagccgtcgc cgaggtcgag
     9001 aaggacgcgg ttcggttgac cgccaaggaa atcgccgacc tcggcaccgg cgtggtcgac
     9061 gccaaggggt acacgctcta ccggttcgac aaggacaagg cgaagccgtc gaagtcctct
     9121 tgcgacggtg actgcgcgaa ggcgtggccg ccggtgctcg ccaaggacag cgtcgacatc
     9181 gaggggatcg atgaggccat tgtcggcacc gtcgtgcggg cagacggcag caggcagctg
     9241 actctcaacg gctggccgct ctaccgcttc gccaaggaca ccgcgccggg cgaggccaag
     9301 ggacacggcg tcggcggcac ctggttcgcc acgacccccg cgggcaagaa ggccgcggcc
     9361 gcggcctccg gctattgagg ccaggatgtc caccccggcc ctctccgcta ccctcggcgc
     9421 cacttggggc gacgtgaggg cgggtgaggg caggggtgac gatcccaggg tttcggccgc
     9481 gccgccgcaa gcaggtcccc ggcgaggact tcgtccggtt cctctacggc gaacacggca
     9541 aggcgctgct ggcctacacg acccggctga ccggcgaccg ggccgccgcc gaggacatcg
     9601 tgcaggagac cctgctgcgg gcctggaagc acgccgacac cctggccgac gagagccgcg
     9661 gctcgacgcg cggctggctg ctcaccgtgg cccgcaacat cgtcaccgac cgggtccgcg
     9721 ccagggccgc ccgcccccag gaggtcggcg aaccgctcga cgcgccggga gccgacagtg
     9781 accacgccga cagcgtcgtc aacgagatgg ccgtcctcgg cgcgctggac cacctgtccc
     9841 gcgaacaccg ggacgtgctg gtcgaggtgt actaccgggg tcggtcggtc gccgaagccg
     9901 cgcaggcgct cggaattccg gcgggtaccg tgaaatcgag gacttaccac gcgttacggg
     9961 ccctgcgcgg cgtgatgggt ccaggcgaga gggaggtgac gaggtgaccg cgttccagca
    10021 cgaccgcgag cagctcggcg ccttcgccct cggcgtcctc gaccagcgcg aggccgacca
    10081 ggtccgcgcc cacctggccc agtgccccga ctgccgccac gaggtcgacg acctgctggc
    10141 gctgcgccgc tcgctcgacg agatcccgcc cgaggcgttc ctggagggtc cgccggacag
    10201 cgacctggtc ctgcagcgca cgctgcgcaa gatgagcagc gagagcgcgc cccgccgcgg
    10261 tctggtcgcc gccggggtgg ccgtgctggc cgccgtggcg ctcggcgggg cgttcttcgc
    10321 gggccggacc accgcccccg agccggtcgc cgcgccgccg cccaccaccg ttcccgggac
    10381 gcgggccggt gcggccaccg acccggacac cggcgcggtg atgagcgtga agctggtgcc
    10441 gcaggcgggc tgggtccggg tcaacgccat ggtgaagggc gccccggttg gcgcgcgctg
    10501 cgaactgagg gtcgtgtcga agtcgggcgg cgagtcggtg ctggcgggca gctggctggt
    10561 gtcggagaag ggcgcccggg acgggacgag cctcgacggc tcagccttga tcgaccccga
    10621 cgacgtcgcc gcggtcgagg tcgtcaccac cgacggcagg cgcatcgtct cggcctcggt
    10681 atagccaggc caggaccgcc agcccgaccg cggcggcggc gagcgagagc accggggtcc
    10741 aaaacgggta ccgatggatg acggcgatcg gctcggggaa ccgcggctgc cagagcaggg
    10801 ccgtttgggg gaccgccaag ccgagcatca ccccgaccac cccggtggcc gccccggcgc
    10861 cgatcgcgcc cgcccctgcg accacggcga acaccaacgc caccaccgct gcccgcaccc
    10921 acaggcgctc atcgacggcc tgggttatcc ccagatagac caccaccgcg ctgatcgcga
    10981 ccccgaccga ggccaccacc tgcctgcgga acggcaacgc ggccgcgaca cccagcgcga
    11041 gccccagtgt catgagcagc cacaccgaca gggtgacccc ggggtatacc agcacggttt
    11101 ccacgggccg cgaacccagt atcggcgtgt tgtcgaattc gatgaaggtc gtcagcacgg
    11161 ccgacgcgct gaccaggcca ccgacgacca cgacaccggc gacgaagcgc gcgcccgcga
    11221 tggccgacac cccgatcacc gcgagcgcgg ccaccagccc cacgattccg cgggctcgca
    11281 cccagtccgc gatgccctcg ccgccaacct ggatcagcgg gaggcccacc tggtcggtca
    11341 ccgcgaacgc gactgggaca agcgatgcga cgatgctcgc gatgagcacc gggaccgctg
    11401 ggcgcggctc tggagcggcc cggcgcgata gccccaccag taccgcgctc acaaggatcc
    11461 ccacgcccgc gaccacaggc agcaggggct gcccgggtgc gatatagagc agctcgaccc
    11521 agcgcaccgc cgaagcgacg acataggcgc cgaggacagt gcccgcgacg gccgcgccca
    11581 gtgcccacgc ccccgaccgg ccgatccagg ccgccgcgcc gaggccaccg gcgagggtca
    11641 gcaggcctgc cgcgctcgac agcgccaaca ccaccgacgt atagggctcg gcgatcccag
    11701 cccctagcca gcacatggaa gcggcgagga gtacccagcg ccacccgacg tgcggccacg
    11761 cccacgccgc cgcgaccccg acgagggccg cgaccggggc ggcggcgtgg acgaaccagg
    11821 gcgggttcag tcccgtcatc ccgatcggcg cgggcatgag cagcaggagt gccaccgcgg
    11881 gcagcacgag cagggcgacg gcggccagtc cggcgtggga ctgacgcggt tcggtcgagg
    11941 tcatccgctg accgtttcca ttctgggagt gctctccgcg gagctgttgg ggcgtggtcg
    12001 gctcagccag ggcagcgcca ccagcgcggc cgccacgatg acaaggatga cgatcggcgg
    12061 ccagtcgact gaccacatgc tcacacgccc cggcgagacc cagggtgcgc cgacggcggt
    12121 gacggtg
//
