LOCUS       NZ_LN850107            10807 bp    DNA     linear   CON 13-AUG-2024
DEFINITION  Alloactinosynnema sp. L-07 isolate Alloactinosynnema sp. L-07
            chromosome I.
ACCESSION   NZ_LN850107
VERSION     NZ_LN850107.1
KEYWORDS    RefSeq.
SOURCE      Alloactinosynnema sp. L-07
  ORGANISM  Alloactinosynnema sp. L-07
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae.
REFERENCE   1
  AUTHORS   Ramaraj,Thiru.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAY-2015) National Center for Genome Resources (NCGR),
            National Center for Genome Resources (NCGR), 2935 Rodeo Park Drive
            East, Santa Fe, New Mexico, 87505, USA
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_900070365.1-RS_2024_08_13
            Annotation Date                   :: 08/13/2024 03:00:54
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,999
            CDSs (total)                      :: 6,934
            Genes (coding)                    :: 6,831
            CDSs (with protein)               :: 6,831
            Genes (RNA)                       :: 65
            rRNAs                             :: 3, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 3, 3, 3 (5S, 16S, 23S)
            tRNAs                             :: 53
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 103
            CDSs (without protein)            :: 103
            Pseudo Genes (ambiguous residues) :: 0 of 103
            Pseudo Genes (frameshifted)       :: 30 of 103
            Pseudo Genes (incomplete)         :: 83 of 103
            Pseudo Genes (internal stop)      :: 1 of 103
            Pseudo Genes (multiple problems)  :: 11 of 103
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 08:22:15
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 874766
            Orig. end                         :: 885573
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            LN850107.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..10807
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="3"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..10807
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10807
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:5807](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..5807)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     gene            complement(411..3575)
                     /locus_tag="BN1701_RS04325"
     CDS             complement(411..3575)
                     /EC_number="3.4.-.-"
                     /GO_function="GO:0008236 - serine-type peptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S8"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1075: alkaline serine protease, subtilase family"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012311.4"
                     /locus_tag="BN1701_RS04325"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="S8 family peptidase"
                     /protein_id="WP_054045709.1"
                     /sec_met_domain="Peptidase_S8 (E-value: 9.3e-60, bitscore:
                     201.0, seeds: 43, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKRTFSFLTALGLVLAGTAPAQAEPTKTATPTKSRSVTLITGDRV
                     VVPDGGRAPSLIPGKGRERIQFRTQKTGGHLTVIPADAMSLVADGTLDRRLFDVTGLLD
                     AGYDDTRADLPLIITGQAPTGMRTMRELPAAKARAVSADKSALASGWQTLTRGGKVWLD
                     GKRKATLDRSAAQIGAPQAWQAGLTGAGVKVAVLDTGVDQTHPDLAAREVGERNFTDSA
                     DAVDRVGHGTHVGSIIAGGGAKYRGVADGARLLDGKVLNDQGYGLDSWIIAGMEWAVEQ
                     GADIVNLSLGGEDTPDIDPVEAALNRLSAEHGTLFVVAAGNSGPSASSVGSPGSADAAL
                     TVGSVERDDSVSFFSSRGPRIGDSAVKPDVTAPGSEIAAAKAAEGVIGNPVEPGYVALS
                     GTSMATPHVAGAAALLAQKNPQWTGARIKAALTASARPTAGAGAFDQGSGRIDVPKALA
                     QNIVTEPTSVSLGLQQWPHDDDQPVTKDLAYRNDSDQAVTFDLTLDVADPQGKPAPAGM
                     FTLSQNRIEVPAGGTATIRVTADTRMGTVDGVYSGSLTAKAGEVAVRTPVAVNREVESY
                     QLKITYLGPDGKPSNSVGGLLVGMDSGTVDFLRPVDGVFTKRVPKGKYLIDSFISDDAS
                     AHHLVHLGVDLTKDTEVVADARATKPLQITPPVEATPTLASEEYVIKTAHGFVGIGVIS
                     SDPRRVHTGQVGPAMPTDQLTWTVNTSWETTDAFYGLAWSQGGSIPTGWVKQVRQQDLA
                     TVRTEVGRAAGDHEAVERLVFPRPTSGEGGGWARVRRTTIPTTITEHLTTDGMRWSGEI
                     LMTTPDPMRIDGAYTSPWRDYRANRTYQERMNVGIYGPAMPDTGYSPGIRYENRLGFRI
                     SLFGDGGGNSGYMITESANTTLYRDGVKIGESDVPGYGEFEVPAERGRYRLTTDVVRPA
                     RYDVSTKMSAAWTFESAKGDTTVPLSTVRFHANLDATNSAPGGRAFALPVTLQRENGST
                     AIPRGLSVDVSFDEGATWRKATVVANSVVLLHHPAGAKSVSLRAKASDGRGGTVEQTIV
                     RAYKLK"
     gene            3805..4560
                     /locus_tag="BN1701_RS04330"
     CDS             3805..4560
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009152546.1"
                     /locus_tag="BN1701_RS04330"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="VOC family protein"
                     /protein_id="WP_054045710.1"
                     /transl_table=11
                     /translation="MVFRDNPWPAGTPCWVDLGTDVERAVSFYTGLFGWDIQVGGEEVG
                     GYGQAFLDGKVVAGFGPLQDPSQPTAWTTYLASADLDGDAAKVKGAGGQIVVDPMDIME
                     FGRMFIAVDPTGAMFGVWEAGTHYGVQLTNEPGSLSWNEHLSGDLEAAKDFYAKVFGYS
                     YDEVGGPLSYVTFSLTEGGDAVGGMGASGVGSWGTYFNVADTDAAAALVEELGGRVIDA
                     PESTPFGRMATVADDQGAIFKLIADVPAR"
     gene            complement(4669..5004)
                     /locus_tag="BN1701_RS04335"
     CDS             complement(4669..5004)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015099301.1"
                     /locus_tag="BN1701_RS04335"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_054045712.1"
                     /transl_table=11
                     /translation="MSEPRDRLAAAQADLLRAVLADGPIPSGFDERAVRVEAAALLAKR
                     RRVVARLIPETAGDLGDRYRPLFDEYARIHPRLEGTRYRDDAAQFEQWATAQGMLAAPK
                     RRWWRRG"
     misc_feature    complement(4804..4806)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(5001..5807)
                     /locus_tag="BN1701_RS04340"
     CDS             complement(5001..5807)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: DUF692"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020671915.1"
                     /locus_tag="BN1701_RS04340"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF692 domain-containing protein"
                     /protein_id="WP_054055607.1"
                     /sec_met_domain="DUF692 (E-value: 4.7e-83, bitscore: 277.1,
                     seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGELGVGIGWRSEIDLTVERMPGVDFVEVVAENVHHDNLPESLRI
                     LRDRGIPVLPHAVSLSLGGADPVDGARIDHLAAVADALDAPLASDHVCFVRAGGLDSGH
                     LMPVPRTRDALDVLVANVKTAQAALGVPLALENIAALIEWPAAELTEARFLTELVERTG
                     CLLLIDVANMWANALNLGQDPTLLLDGLPLDQVAYVHVAGGMETDGVYHDTHAHPVPPG
                     VLDLLRELCTRVRPPGVLLERDDFYPTDAALKAELDAIRAVLAETA"
     gene            complement(5821..6711)
                     /locus_tag="BN1701_RS04345"
     CDS             complement(5821..6711)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:TIGR04222.1"
                     /locus_tag="BN1701_RS04345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="TIGR04222 domain-containing membrane protein"
                     /protein_id="WP_054045714.1"
                     /transl_table=11
                     /translation="MNEPWGLSGPEFLRIYLVVFFFALLFALAVRIMVRTGSADTRPTG
                     GTIRPGQLSMHELAYLAGGARRVVETAIARLIDQGRIRPSRKGSVSVVEGSTSADPVDM
                     AVLSDVKRYGDRAIHLLVDKVSRVDAVTGVGDSLVRKGLLVGEAAARARWGALPLAVLF
                     VVGAARWINGISDGRPIGWLSLALLATGLAMVLVYRMPVPTRTYAGERVLREAKPNGRR
                     VPSEEAALLGAAGVVGIVAFSGLGAHPDEEINTAMASHRSSHDGGSSSSGGDGGGGSSS
                     SCGGGCGGGGGGCGG"
     misc_feature    complement(6761..6776)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: medium, score: 16.67"
                     /tool="antismash"
     misc_feature    6785..6801
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: weak, score: 20.59"
                     /tool="antismash"
     gene            complement(6817..7266)
                     /gene="msrB"
                     /locus_tag="BN1701_RS04350"
     CDS             complement(6817..7266)
                     /EC_number="1.8.4.12"
                     /GO_function="GO:0033743 - peptide-methionine (R)-S-oxide
                     reductase activity [Evidence IEA]"
                     /GO_process="GO:0006979 - response to oxidative stress
                     [Evidence IEA]"
                     /GO_process="GO:0030091 - protein repair [Evidence IEA]"
                     /codon_start=1
                     /gene="msrB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018684638.1"
                     /locus_tag="BN1701_RS04350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="peptide-methionine (R)-S-oxide reductase MsrB"
                     /protein_id="WP_054045716.1"
                     /transl_table=11
                     /translation="MKPVVGATPRVVKSEQEWRAQLDPREFAVLRKAGTEPAWTGEYTE
                     TKTVGVYRCRACGAELFRSDTKFESHCGWPSFFSPLAGESVILREDREFGMVRTEVLCG
                     SCHSHLGHVFEGEGYPTPTDQRYCINSISLTLVPDEDTSSPAQEA"
     gene            complement(7305..7631)
                     /locus_tag="BN1701_RS04355"
     CDS             complement(7305..7631)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018684637.1"
                     /locus_tag="BN1701_RS04355"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_054055608.1"
                     /transl_table=11
                     /translation="MPDDDPRPPTPPAPQPGPQGRFADDLIGLDPDDPEARAFAEHLDR
                     VQRVRPGFTVEGYIGGVGDFADAANRLGGHRRLTAGILVALIMLGVIIAVWDTLVFILT
                     TLFA"
     gene            complement(7681..8949)
                     /gene="hisS"
                     /locus_tag="BN1701_RS04360"
     CDS             complement(7681..8949)
                     /EC_number="6.1.1.21"
                     /GO_component="GO:0005737 - cytoplasm [Evidence IEA]"
                     /GO_function="GO:0004821 - histidine-tRNA ligase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0006427 - histidyl-tRNA aminoacylation
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="hisS"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018684636.1"
                     /locus_tag="BN1701_RS04360"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="histidine--tRNA ligase"
                     /protein_id="WP_054045719.1"
                     /transl_table=11
                     /translation="MKIDNSPARGTRDLLPATVAVRDHVLAQITEVYHRFGYQRIETPA
                     LENIERLTGGQGGENEKLIYRILRRGLDETVSAETTLGELVDLGLRYDLTVPLTRFYGN
                     NQATLPQPFRSFQFGPVWRAERPQKGRYRQFYQCDIDMLGEESVLAEVELIEATTEALA
                     AVGLDGTTVRVSDRRFLSALAAGAGLPEEEWTGLFITLDKLDKVGWDGVRAELAGRGLD
                     GDRVDQLQASITSLQGIDSAKLGDQLSASVPGLADEVIADLSATADALRALGETRPISW
                     EFDPTLVRGMGYYTGQIFEIVHPGSSGSVAGGGRYDRLIGRSLGRDVPACGFSIGFERI
                     VDLLGGQAPGERVAVLYEADVALPAVTGAARTLRGTGRTVSPIRRRGKFGAQLGRLEEW
                     GFTSFVHLKADSADLDERPLGDR"
     gene            9046..10095
                     /gene="ligD"
                     /locus_tag="BN1701_RS04365"
     CDS             9046..10095
                     /EC_number="6.5.1.1"
                     /codon_start=1
                     /gene="ligD"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018334472.1"
                     /locus_tag="BN1701_RS04365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="non-homologous end-joining DNA ligase"
                     /protein_id="WP_054055609.1"
                     /transl_table=11
                     /translation="MATEAVEIKVGERAVRVSNPDKVYFAELGLTKRQIVEYFLSVGDG
                     ILGALRDRPTTLERWPGGVFEGAKLSTRADHRGDAFYQKRIPKGAPDYVETARIAFPSG
                     RPADEVCPTELAVVAWAANLGTLTFHPWPVSRADVDRPDQLRIDLDPQPGTDFSDAVRV
                     AFEVRALLASMGITAFPKTSGGRGLHLYVPIEPRWTFVEARRALIALGREMERRMPDQV
                     TVKWWKEERGQRIFIDYNQMARDRTIASAYSIRPTQRALVSAPVTWDEVGDAHPQDFSV
                     LTMPERFAQVGDLHAGVATEAYSLEPLIELVERDQRDHDLGDMPYPPEYPKMAGEPKRV
                     QPSKARDDT"
     gene            10215..10409
                     /locus_tag="BN1701_RS04370"
     CDS             10215..10409
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018684633.1"
                     /locus_tag="BN1701_RS04370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_054055610.1"
                     /transl_table=11
                     /translation="MPGSYLVRYVGGPLDGRVDTLDASPETPKSTVTHVHLHGGPKIVH
                     HYDLHYAVEYGCEYRLREH"
     gene            complement(10414..10623)
                     /locus_tag="BN1701_RS04375"
     CDS             complement(10414..10623)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="BN1701_RS04375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_054045721.1"
                     /transl_table=11
                     /translation="MTVRYLWWRSCYDGALHAFPVAPGARLAHQHYRASCTHAAPPDLA
                     ADEPAASRCELCLLIIGELATPST"
ORIGIN
        1 cagtggaccg tggcggaatc ggcgcgggtt cgacagcctg gtccaactcg ccaccggcat
       61 cgcccaggac tcaggggatc ggctggtctc gctgcccgcg caagcgcttg accacgccac
      121 cggctggctt gccgcggccg ctgtcatgac cgcgttgcgc cgtcgggccg tcgagggcgg
      181 gacctggcac gtgcgactct cgttggccag gacggcgcgc tggttcgatg acctcggccg
      241 ggtggaatcg gtggaggttc caggtttcgc cgatccgtat ctgtctgata tggacagtga
      301 tttcggcgtt gttaggcacg tgcggtgtcc aggtgggctg cccggatcgc cgccggggta
      361 cgggcatggt ccccgtactc ccggcagcga cccggcggcc tggtggtgac ctacttcagc
      421 ttgtaggccc gcacgatcgt ctgctcgacc gtgccgccgc ggccgtcgga cgccttggcc
      481 cgcagcgaca ccgacttcgc gcccgccggg tggtgcagca gcaccaccga gttggccacg
      541 accgtcgcct tgcgccaggt cgcgccctcg tcgaaggaca cgtcgaccga cagtccacgg
      601 gggatcgcgg tcgacccgtt ctcccgctgc agcgtcaccg gcaacgcgaa cgcccgaccg
      661 ccgggcgcgc tgttggtcgc gtccaggttg gcgtggaacc gcaccgtcga cagtggcacc
      721 gtcgtgtcgc ccttcgcgga ctcgaaggtc cacgccgccg acatcttggt gctgacgtcg
      781 taccgggcgg gccggaccac gtcggtggtg agccggtagc ggccccgctc agcgggcacc
      841 tcgaactcac cgtagcccgg gacgtcgctc tcaccgatct tcacgccgtc gcggtacaga
      901 gtggtgttgg ccgactcggt gatcatgtat cccgagttgc ccccgccgtc gccgaacagg
      961 ctgatccgga aacccagcct attctcgtac cggatgcccg gcgagtagcc ggtgtccggc
     1021 atcgccggtc cgtagatccc gacgttcatc ctttcctggt acgtgcggtt cgcgcggtag
     1081 tcccgccacg gcgaggtgta ggcaccgtcg attcgcatgg ggtccggggt ggtcatcaag
     1141 atttcgcccg accagcgcat gccgtcagtg gtgaggtgct cggtgatcgt cgtggggatc
     1201 gtcgtccgcc ggaccctggc ccacccgccg ccctcgcccg aggtcggcct cggaaacacc
     1261 aaccgctcga cggcctcgtg gtcacccgcc gcccggccca cctcggtgcg cacggtggcg
     1321 aggtcctgct gccgcacctg cttgacccag ccggtcggga tcgatccgcc ctgcgaccag
     1381 gccaggccgt agaacgcgtc ggtcgtctcc caactggtgt tgacggtcca ggtcagctgg
     1441 tcggtaggca tcgccgggcc cacctggccg gtgtgcacgc ggcgtggatc cgagctgatg
     1501 acgccgatcc cgacgaagcc gtgcgctgtc ttgatcacgt actcctccga cgccagcgtc
     1561 ggcgtcgcct cgaccggcgg ggtgatctgc agcggcttgg tggccctggc gtcggccacg
     1621 acctcggtgt ccttggtcag gtcgacgccc aggtgcacca ggtggtgcgc actcgcgtcg
     1681 tcggagatga agctgtcgat caggtacttg cccttgggca cgcgcttggt gaacacgccg
     1741 tcgaccgggc gcaggaagtc gacggtaccg ctgtccatgc cgacgagcag gccgcccacc
     1801 gagttgctcg gcttgccgtc cggaccgagg taggtgatct tgagctggta gctctcgacc
     1861 tcacggttca ccgcgacggg cgtacggacc gcgacctcgc ccgccttggc cgtcagcgag
     1921 ccggagtaga cgccgtcaac cgtgcccatc cgggtgtcgg ccgtgacgcg gatggtcgcc
     1981 gtcccgcccg cggggacctc gatcctgttc tgcgacaacg tgaacatccc ggcgggcgcg
     2041 ggcttgccct gcgggtcggc gacgtcgagc gtcaggtcga aggtgaccgc ctggtcgctg
     2101 tcgttgcggt aggcgaggtc tttggtcacc ggctggtcgt cgtcgtgcgg ccactgctgc
     2161 agcccgaggc tgaccgaggt cggctcggtg acgatgttct gcgccagggc cttcggcacg
     2221 tcgatccggc cggacccctg gtcgaaggcg cctgccccag ccgtgggccg cgcggacgcg
     2281 gtgagcgccg ccttgattcg ggcgccagtc cactgtggat tcttctgggc gagcagcgcc
     2341 gcggcgcccg cgacgtgcgg ggtggccatg gacgttccgg acagcgccac gtagccgggt
     2401 tcgacggggt tgccgatgac accctcggcc gccttggccg cggcgatctc cgagcccggc
     2461 gcggtgacgt ccggcttgac cgcgctgtcg ccgatccgcg ggccccggct ggagaagaac
     2521 gacaccgagt cgtcccgctc gaccgagccg acggtgagcg ccgcgtccgc gctgccgggg
     2581 gagccgaccg aactcgccga cgggcccgag ttgcccgccg ccaccacgaa cagggtgccg
     2641 tgctcggcgg agagccggtt cagcgccgct tccaccggat cgatgtccgg ggtgtcctcg
     2701 ccgcccaggc tcaggttgac gatgtcggcg ccctgctcga ccgcccactc catccccgcg
     2761 atgatccacg agtccaggcc gtagccctgg tcgttgagca ccttgccgtc gagcagtcgc
     2821 gcgccgtcgg cgacgccgcg gtacttcgcg ccgccaccgg cgatgatcga gccgacatgc
     2881 gtgccgtggc cgacccggtc gaccgcgtcg gcgctgtcgg tgaagttgcg ctcgccgacc
     2941 tcgcgcgcgg ccaggtcggg atgggtctgg tcgacaccgg tgtcgagcac cgccaccttg
     3001 acgcccgcgc cggtcagccc ggcctgccac gcctgcggcg cgccgatctg ggccgcgctg
     3061 cggtcgagcg tcgccttgcg cttgccatcg agccagacct tcccgccgcg cgtgagggtc
     3121 tgccatccgc tcgccagcgc ggacttgtcc gcgctcaccg ctcgggcctt ggccgcgggc
     3181 agttcccgca tggtccgcat cccggtcggc gcctgcccgg tgatgatcag cggcaggtcg
     3241 gcgcgggtgt cgtcgtaccc ggcgtcgagc aggccggtga cgtcgaacag gcgccggtcg
     3301 agcgtgccgt cggcgacgag actcatggcg tcggcgggaa tgacggtcag gtgaccgccg
     3361 gtcttctggg ttcggaactg aattcgttcc cggcctttgc cgggaatcaa ggatggtgcc
     3421 cggccgccgt cggggacgac cacccggtcg ccggtgatca gcgtgaccga acgggatttg
     3481 gtcggtgtgg cggtcttggt tggttcggct tgcgctggag cggtgcccgc gagcaccagc
     3541 cccagggcgg tgaggaagga gaatgtccgt ttcatctgtg gcgtcagccc ccactaatcc
     3601 gcaaaaagaa caggacatga gggcgaacaa gggaaatccc cagaatccaa cccccagttc
     3661 ttccgaaggt aatgatcaac ggggggcggc gcaaggaaga tgatcttgac tcgggacgtt
     3721 cactcgaatg gccgtgatcg ttcgtgcggg ctgggccgtt cggggttagc gtggcagccc
     3781 gatcccgagt aaaggaggtt cgtcatggtc ttccgcgaca acccgtggcc cgcgggtact
     3841 ccgtgctggg tcgacctggg caccgacgtc gagcgagcgg tctccttcta caccggcctg
     3901 ttcgggtggg atatccaggt cggcggcgag gaggtcggcg ggtacgggca ggcgttcctc
     3961 gacggcaagg tcgtcgccgg gttcggtccg ctgcaggacc cgagccagcc caccgcgtgg
     4021 acgacctacc tggcatcggc cgacctcgac ggcgatgccg cgaaggtcaa gggcgcgggc
     4081 ggacagatcg tcgtggaccc gatggacatc atggagttcg gcaggatgtt catcgccgtc
     4141 gacccgaccg gggccatgtt cggcgtgtgg gaggcgggca cgcactacgg cgtgcaactg
     4201 accaacgagc cgggttcgct gagctggaac gaacacctca gcggcgacct tgaggcggcc
     4261 aaagacttct acgccaaggt cttcggatac agctacgacg aggtcggcgg cccgttgtcc
     4321 tacgtcacgt tctcgctcac cgagggcggc gacgcggtcg gcggcatggg cgcgtccggt
     4381 gtcggttcgt gggggacgta cttcaacgtc gccgacaccg acgccgcggc cgccttggtc
     4441 gaggaactcg gcggcagggt catcgacgcg ccggagtcga cgccgttcgg ccggatggcc
     4501 accgtcgccg acgaccaagg cgcgatcttc aagttgatcg ccgacgtgcc cgcgcggtaa
     4561 cgcgccagga cggtgcccgg gtgtcgccgg gtggtgccga tgcgcgtcgg cgccacccgg
     4621 cggtccgacc accggctgag ccggttgccc cggtcggggt ctgacgggtc agccgcggcg
     4681 ccaccagcgg cgcttgggtg cggccaacat tccttgggcg gtcgcccatt gttcgaattg
     4741 tgcggcatcg tctcggtagc gggtgccctc cagacggggg tgaatgcgcg cgtactcgtc
     4801 gaataagggg cgatagcggt cgcccaggtc gcccgccgtc tccggaatca gccgcgcgac
     4861 cacccgacgc cgtttcgcca gcagcgccgc cgcctcgacg cgcaccgccc gttcgtcgaa
     4921 tcccgaagga atgggcccgt ccgccagcac cgcccgcagc aggtccgcct gggcggcggc
     4981 gagacggtca cggggttcgc tcacgctgtc tccgctagta ccgcgcggat cgcgtcgagt
     5041 tcggccttca gtgccgcgtc ggtcgggtag aagtcgtcgc gttcgagcag cacccccggc
     5101 ggccggaccc gggtgcacag ctcacgcagt aggtcgagca cgccaggcgg caccgggtgc
     5161 gcgtgggtgt cgtgatagac cccgtccgtc tccatcccgc ccgcgacgtg cacatacgcc
     5221 acctggtcca gcggcagtcc gtcgagcagc agggttgggt cctggccgag gttgagcgcg
     5281 ttggcccaca tgttcgccac gtcgatcagc agcaggcagc cggtccgctc gaccagctcg
     5341 gtgaggaacc gcgcctcggt cagctccgcc gcgggccatt cgatcagcgc ggcgatgttc
     5401 tccagcgcca gcggcacccc cagcgccgct tgagccgtct tgacgttggc caccagcacg
     5461 tccagtgcgt cgcgggtgcg ggggaccggc atcagatgac cagagtcgag gccgcccgcg
     5521 cgcacgaaac acacatggtc gctggccagc ggcgcgtcca gcgcgtcggc caccgccgcg
     5581 agatggtcga tccgggcgcc gtcgaccggg tcggcgccgc ccagcgacag cgagacggcg
     5641 tgggggagga cggggatccc gcggtcccga aggatccgca gcgactccgg gaggttgtcg
     5701 tggtgcacgt tctccgcgac cacctcgacg aagtcgaccc ccggcatccg ctcgacggtc
     5761 agatctatct ccgaccgcca gccgatgcct accccgagct cacccacgcc acccactgtc
     5821 tcatcccccg cagccaccgc caccgccacc gcagccaccg ccacagctgc tgctgctgcc
     5881 accgccgccg tcgccacccg acgacgagga accgccgtcg tggctggacc gatgtgacgc
     5941 catcgcggtg ttgatctcct cgtccgggtg ggcgccaaga ccgctgaacg ccacgatccc
     6001 gacgacgccg gccgcaccca gcaacgccgc ttcttcactg ggcaccctgc ggccgttcgg
     6061 cttggcctcg cggagcacgc gttcccccgc gtaggtccgg gtcggcaccg gcatgcggta
     6121 caccagaacc atggccaggc cggtcgccag cagcgccagc gacagccagc cgatcggccg
     6181 tccgtcggat atcccgttga tccaccgcgc cgcgcccact acgaagagca cagccagcgg
     6241 cagggcaccc catcgtgccc gcgccgccgc ctcgccgacc agcaacccct tgcgcaccag
     6301 ggaatccccg acgccggtga cggcgtcaac cctgctgacc ttgtcgacga gcaagtgaat
     6361 cgcgcggtcc ccgtaccgct tgacatccga caggacggcc atgtcgacgg gatcggcgga
     6421 cgtggacccc tcgaccacgc tcaccgatcc cttgcggctc ggccggatcc tgccctggtc
     6481 gatcaacctg gcgatggccg tctccacgac gcgccgcgcg ccgcccgcca ggtacgccag
     6541 ctcgtgcatc gagagctgac caggccggat cgtcccgcct gtcggccgcg tgtcggcgga
     6601 tcccgtacgg accatgatcc gtaccgccaa cgcgaacaac agggcgaaga agaacacgac
     6661 cagatagatc ctcaggaact caggtcccga gagtccccac ggctcgttca ttgcccaccc
     6721 ccttcgtcag tcaccctgac aaggcagatg gttctgggtg tgtgaccgcg cgcacaagca
     6781 ggcttgacca agatttaggc aagccgtggg tgagatttag gcttcttgag ccggacttga
     6841 ggtgtcctcg tccgggacca gcgtcagcga gatcgagttg atgcagtagc gctggtcggt
     6901 cggggtcggg tagccctcgc cctcgaagac gtggccgagg tggctgtggc agctgccgca
     6961 caggacctcg gtgcgcacca tgccgaactc gcggtcctcc cgcaggatga cgctctcgcc
     7021 cgccagcggc gagaagaacg acggccagcc gcagtgcgac tcgaacttgg tgtcgctgcg
     7081 gaacagctcg gcgccgcagg cccggcaccg gtagaccccg acggtcttgg tttcggtgta
     7141 ctcgccggtc cacgcgggct cggtcccggc cttgcgcagc accgcgaact cgcgcgggtc
     7201 cagttgcgcg cgccattcct gttcggactt gacgacccta ggggtcgcgc cgacaacggg
     7261 tttcaccgga aatcgctcct gacttctctg gtgcggttgg gcgctcaggc gaacagcgtg
     7321 gtgaggatga acaccagcgt gtcccacacg gcgatgatga ccccgagcat gatcagcgcg
     7381 accaggatgc ccgcggtgag cctgcggtgt ccgccgagcc ggttggccgc gtcggcgaag
     7441 tcgccgacgc cgccgatgta gccctcgacg gtgaagccgg ggcgcacccg ctggacccgg
     7501 tcgaggtgct cggcgaacgc cctggcctcg gggtcgtcgg ggtccaaacc gatcaggtcg
     7561 tcggcgaatc ggccctgcgg gcccggctgc ggggccggtg gcgtcggagg gcgcgggtca
     7621 tcatcgggca tgccgaagga accggtcgcg accatatgtc cacggtaacc tggtcgaccc
     7681 ttacctgtcg cccagcgggc gctcgtcgag gtcggccgag tcggctttga ggtggacgaa
     7741 cgaggtgaat ccccactcct ccagcctgcc gagttgggcg ccgaacttgc cgcgcctgcg
     7801 gatcggggac acggtgcgac ccgtgccgcg cagcgtgcgc gccgccccgg tgaccgcggg
     7861 cagcgcgacg tcggcctcat agaggaccgc gacgcgctcg ccgggggcct ggccgccgag
     7921 caggtcgacg atgcgctcga agccgatgga gaagccgcac gcgggcacgt cgcggcccag
     7981 cgaccggccg atgagccggt cgtagcgccc gccgcccgcc accgagcccg acgagccggg
     8041 gtgcacgatc tcgaagatct ggccggtgta gtagcccatg ccgcgcacca gcgtcgggtc
     8101 gaactcccag ctgatcgggc gggtctcacc gagcgcgcgc agggcgtcgg cggtggcgga
     8161 caggtcggcg atgacctcgt cggccagacc ggggaccgac gccgacagct gatcgcccaa
     8221 cttggcggag tcgatgccct ggaggctggt gatgctcgcc tggagctggt cgacccggtc
     8281 gccgtcgagg ccccggcccg ccaactcggc gcgcacgccg tcccacccga ccttgtcgag
     8341 cttgtcgagg gtgatgaaca ggccggtcca ctcctcttcc ggcaggcccg cgcccgcggc
     8401 cagcgcggac aggaagcgcc ggtcggagac ccggacggtg gtcccgtcga ggccgacggc
     8461 ggccagcgcc tcggtggtgg cctcgatcag ctcgacctcg gccaggacgc tttcctcgcc
     8521 gagcatgtcg atgtcgcact ggtagaactg ccggtagcgg cccttctgcg gccgctcggc
     8581 ccgccagacc gggccgaact ggaacgagcg gaacggctgg ggcagcgtgg cctggttgtt
     8641 gccgtagaag cgggtcagcg ggaccgtgag gtcgtagcgc aaaccgaggt cgaccagctc
     8701 acccagcgtg gtttcggcgg acaccgtctc gtccaggccg cggcgcagga tccggtagat
     8761 cagcttctcg ttctcgccgc cctggccgcc ggtcagccgc tcgatgttct ccagcgcggg
     8821 ggtctcgatg cgctggtagc cgaaccggtg gtagacctcg gtgatctggg ccaggacatg
     8881 atcgcgcacg gcgacggtcg cgggcagcag gtcacgggtg cccctcgcgg ggctgttgtc
     8941 gatcttcacc gggttcctca ggtcgagcgg tcgctgaccc gcagtacggt accgggactg
     9001 gccgaagccg cgcgcgcgcg ttgtccttcg ccgtaggctg tggtcgtggc gactgaggcc
     9061 gtggagatca aggtcggcga gcgagccgtt cgagtgtcca atccggacaa ggtgtacttc
     9121 gccgaactgg ggctgaccaa gcgccagatc gtcgagtact tcctgtcggt gggcgacggc
     9181 atcctgggcg cgctgcgcga ccgcccgacc accctggaac gctggccggg cggcgtcttc
     9241 gaaggcgcca aactgtccac cagagccgac caccggggcg acgctttcta tcagaaacgc
     9301 atccccaagg gcgcgccgga ctacgtcgag accgcccgga tcgccttccc cagcggcagg
     9361 cccgccgacg aggtgtgccc gacggaactg gcggtggtgg cgtgggcggc caacctgggc
     9421 accctgacgt tccacccctg gccggtcagc cgggccgatg tggaccggcc agaccagctg
     9481 cgcatcgacc tcgaccccca gcccggcacc gacttctcgg acgcggtccg ggtggccttc
     9541 gaggtccgcg ccctgctggc gtcgatgggc atcacggcgt tcccgaagac ctccggcggc
     9601 cgtgggctgc atctttatgt gccgatcgag ccccgctgga ccttcgtcga ggcccgccgc
     9661 gccctgatcg cgctgggtcg ggagatggaa cggcggatgc cggaccaggt cacggtcaag
     9721 tggtggaagg aggagcgtgg gcagcggatc ttcatcgact acaaccagat ggcccgcgac
     9781 cgcacgatcg cctcggccta ctccattcgc cctactcagc gcgccctcgt ctcggcgccg
     9841 gtgacctggg atgaggtggg tgacgcacac ccgcaggact tctcggtgct caccatgccg
     9901 gagcggttcg cccaggtcgg cgatctccac gcgggggtgg cgaccgaggc gtattcgctg
     9961 gagccgctga tcgagctggt cgaacgcgac cagcgcgacc acgacctcgg cgacatgccg
    10021 tatcccccgg agtatccgaa gatggcgggc gaacccaagc gggtccagcc ttccaaggcc
    10081 cgcgacgaca cctgacagcg gtcgaaggct ttcgtcagtg tggttccgcg agacgttcgg
    10141 cgatgtggcc attggcgacc atcgccgctg acgaattcgc cgattacact gacagggggc
    10201 gaaaggagac cgcgatgccg ggttcttacc tagtgcgcta tgtcggcggt cccctcgacg
    10261 gccgggtcga cacgctcgac gcctcgccgg agactcccaa gtccacggtc acccatgtgc
    10321 atctgcacgg cgggcccaag atcgtgcacc attacgacct gcactacgcc gtcgagtacg
    10381 gctgcgagta tcggctgcgg gaacactgac gtcctatgtg gacggtgtgg cgagctcgcc
    10441 gatgatgagc aggcacaact cgcagcgcga cgcggcgggt tcgtcggcgg ccagatccgg
    10501 tggggcggcg tgggtgcagg aggcgcggta gtgctggtgg gccaagcggg cgcccggggc
    10561 caccgggaac gcgtgcagcg cgccgtcgta acagcttcgc caccacaggt accgcacggt
    10621 catctcggca acctaagtcc gtcgctgcca gacggcatcc ggtgacgtcc gttcgggtgt
    10681 cgcctgggtg gggtcgactg ggctgtcggt ccctgcgggc acactacgcc cggacttcag
    10741 cgaaggggag gacctcgatg gcgagggtag tggcgctgtc cgccgaggac atcgagcgga
    10801 tcggcgc
//
