LOCUS       NZ_FHRS02000012        18392 bp    DNA     linear   CON 12-DEC-2024
DEFINITION  Streptococcus pneumoniae strain GPSC18 substr. ST1797
            ERS455146SCcontig000012, whole genome shotgun sequence.
ACCESSION   NZ_FHRS02000012
VERSION     NZ_FHRS02000012.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1
  CONSRTM   Pathogen Informatics
  TITLE     Direct Submission
  JOURNAL   Submitted (08-FEB-2016) WTSI, Wellcome Trust Sanger Institute, CB10
            1SA, United Kingdom
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_900055005.2-RS_2024_12_12
            Annotation Date                   :: 12/12/2024 02:43:55
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.9
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 2,241
            CDSs (total)                      :: 2,189
            Genes (coding)                    :: 2,009
            CDSs (with protein)               :: 2,009
            Genes (RNA)                       :: 52
            rRNAs                             :: 2, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1, 1 (5S, 16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 45
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 180
            CDSs (without protein)            :: 180
            Pseudo Genes (ambiguous residues) :: 0 of 180
            Pseudo Genes (frameshifted)       :: 73 of 180
            Pseudo Genes (incomplete)         :: 93 of 180
            Pseudo Genes (internal stop)      :: 57 of 180
            Pseudo Genes (multiple problems)  :: 36 of 180
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 17:31:24
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 0
            Orig. end                         :: 18392
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            FHRS02000012.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..18392
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="lanthipeptide-class-i"
                     /region_number="1"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..18392
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..18392
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[4215:8392](-)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(4216..8392)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     misc_feature    complement(88..101)
                     /note="TFBS match to CatR, H2O2-responsive repressor,
                     confidence: medium, score: 21.45"
                     /tool="antismash"
     gene            complement(200..1426)
                     /locus_tag="A1898_RS06060"
                     /old_locus_tag="SAMEA2521606_01227"
     CDS             complement(200..1426)
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1020: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000862399.1"
                     /locus_tag="A1898_RS06060"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA2521606_01227"
                     /product="MFS transporter"
                     /protein_id="WP_000862428.1"
                     /transl_table=11
                     /translation="MKVFLQNRDFRQLTINQWISTLGDTIFYLAFLNYVADASFAPLAI
                     LLITISETLPQVLQIFLGVLADFQHHRVLKYTVISFTKFLLYSIVSLSLSGQSFSLLLV
                     TFICLLNLLSDTLSYFSGAMLTPIFIRIIGQDHLAEAIGFKQSTVSLVKTISNILGGVL
                     LGILSIQFISLLNALTFLIAFLGILFIKTDLLKVEKTISYQEGLSVKSFCQHLLQSSKL
                     IWNMNKVLLVLFIISTSQAVINVTVPISTLFLRNQPFLNLQTGQSLALLATLELSALIL
                     GSLMSGYLQHTISIKTALYASLVIQLLLLVGFATVRFDWILIFSTLDAFFAGILSPRLQ
                     ELVFKQIPEESMGAVQSSIGAITVVLPSLFTIALVTIATSFGTLAVSFVLLLFLLVAFV
                     MLLNIRESI"
     gene            complement(1498..2163)
                     /locus_tag="A1898_RS06065"
                     /old_locus_tag="SAMEA2521606_01228"
     CDS             complement(1498..2163)
                     /EC_number="3.4.-.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abi"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000720786.1"
                     /locus_tag="A1898_RS06065"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA2521606_01228"
                     /product="CPBP family intramembrane glutamic endopeptidase"
                     /protein_id="WP_000720786.1"
                     /sec_met_domain="Abi (E-value: 7e-18, bitscore: 56.9,
                     seeds: 823, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKIISHRYFIIVFLLVIADQKFSALVLRSDLVTGLSDFAYYLSD
                     MMLNFLVVLFALIAMIWSGKWQKINSRKFKGSYLFYSFLALLAFVVWNFVTFFLFPPTR
                     NEISYQHAAPTFTGATAFLMYFFYPVIVGPIFEEIIHRGLVMTALEKGKKWGLDVLGSA
                     VLFGVSHISNHGWVLTDFFVYMGGGLIFAVLFRMTKSIYWPIGLHIVYNGIGQLLMLL"
     gene            complement(2175..2852)
                     /locus_tag="A1898_RS06070"
                     /old_locus_tag="SAMEA2521606_01229"
     CDS             complement(2175..2852)
                     /EC_number="3.4.-.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abi"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000738309.1"
                     /locus_tag="A1898_RS06070"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA2521606_01229"
                     /product="CPBP family intramembrane glutamic endopeptidase"
                     /protein_id="WP_000738303.1"
                     /sec_met_domain="Abi (E-value: 3.1e-20, bitscore: 64.4,
                     seeds: 823, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKMKEVKFHLATGLLILTYYLIFNVTSDLDFMAALSDNMYYVFQ
                     VLLVLILGTIATIAFVKSEHWKECGRFQFRWSYLGVFLLSFFLLFVWANLTTYIFPRTQ
                     NGSTVVEVATNLTGISYFVTRILYTSIIAPVSEEVVCRGLLMTSLSKVKRYYLDVLVSA
                     AIFGAMHVLQYGWITTDFIKYFGMGLIFCMMFRYTRSIYWAIALHASWNSFLLIVTLLV
                     FGY"
     gene            complement(2931..4187)
                     /locus_tag="A1898_RS06075"
                     /old_locus_tag="SAMEA2521606_01230"
     CDS             complement(2931..4187)
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1020: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000722643.1"
                     /locus_tag="A1898_RS06075"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA2521606_01230"
                     /product="MFS transporter"
                     /protein_id="WP_000722643.1"
                     /transl_table=11
                     /translation="MKKILNNKLYMKVLVSDLISNFGDTLYFIALMTYVTEIKSSNLAI
                     SIVNISETIPILFTIFFGIIADRTLNKVGMIIKTLWIRTILYLLVAVVMNFKESILVVI
                     LASIVNLISDTLGQFENGLFYPISNRIVKKSDREETMAFRQTATSTMNIVNQSLGAFLI
                     TFLSFFHLALINSLTFAISLLITLAIKSQINNFYIDKTPSTKVSKVDFKATFSDIISNL
                     KLSLKHLFSLTNMKTVLLVIPILNGSLAIIIPLAVVNLSKSSALTIISSATTISVLGIS
                     TVSGGILGGTLILISKKFKNLSIENLLKMNLMTILLSFIAFYYQNIYFIVLTLFLSSVF
                     VSALNPKIGAIIFNNLDETKLATIFGGMVTYFQLGDVVSRLLFSTLVIYLSYTYIAVIY
                     MILVLIVAIYTFRRVQTTS"
     gene            complement(4216..5493)
                     /locus_tag="A1898_RS06080"
                     /old_locus_tag="SAMEA2521606_01231"
     CDS             complement(4216..5493)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001244305.1"
                     /locus_tag="A1898_RS06080"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA2521606_01231"
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_001244305.1"
                     /sec_met_domain="LANC_like (E-value: 2.8e-49, bitscore:
                     159.6, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRNIIKKYDEIINKVDSLVLDNNIIDLLQRSCYTENRSYLSEYPS
                     IIIYLSYRLANCDDNEHSKLLYNRVNYYLHELLKSIKLNSRNNISMCYGFSGYVYALKL
                     LPKRSKEYSKLLETLETILVSLTRDRLSEIKKSNKVKEEYIDVIQGVSSVGKYFLSKDK
                     LTSNQELLLKGVLNYLAGVINNKPTIYPEYMPNEKLKRKFPNGYINLGVAHGILGPLYV
                     LALGFKKFNMPEYLISLKKGLSYYEKTFQTNKIGKIIGWNGRVSAEVESEKFEYNLSWC
                     YGSLGMARVLYNISKIIDIPKLQELATDVFHSSIYYLNSSEILNNAICHGRSGIMLLFN
                     LMYLDTGESQFKAISDNLFKEIVNKATDSEYIFVERDIYFRGVNYDEVIEYIDFGLLNG
                     VSGIVLALMAQRTGNASPLAEMFFMQ"
     gene            complement(5477..8392)
                     /locus_tag="A1898_RS06085"
                     /old_locus_tag="SAMEA2521606_01232"
     CDS             complement(5477..8392)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000472732.1"
                     /locus_tag="A1898_RS06085"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA2521606_01232"
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_000472731.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 1.8e-80, bitscore:
                     262.7, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 4e-09,
                     bitscore: 29.1, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 2.9e-16, bitscore:
                     51.8, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFKIKDNYIYRQCVNDSILIEKLNENNLEIFFDSKIFQEMLMVAN
                     PRFFNELTKEKIYQNSTFRNYAKRSLTRATPFGLFSSVGVGSFSKVSYPQQIRENYSKK
                     VSVSGEWISSLCMMLENEDSVLLQLHLQWNQKVLELSDKYQLNNINYWGVSEQSRDILI
                     KKTALLEFIKKLTYKSEVSVLDLVQEIQTKSPNLETQKIIDYLRNLIISEFLFTNLRKV
                     VINHNCLDNLIYILSSINEQTKLTTDLLQLKSCIEKYSKSELGEGILQYAEICEKMSHI
                     FNEEKQRYLKVDLVNSYDSLLPKDLKKTLEDFVNFISRINLGKDYRNKELISYTEKFVE
                     KYGEYVEVPIKQLLDSKLGLGIPKQNLEPYSILSSVAEQTFLSYLSKEIFKAVKNNKKE
                     IDISNIPPELLYPNLDRFAVNQFELYCEMKNFGEQPVISIVPNTGSDMIGKSIGRFASY
                     FLNSNIELDSRVDNVELIEFPSDNKNLNVMSSHHGHSKKLLLSYEDDFDIDSLELDFLV
                     VGVERVNEHYKLYFRDLRTDLIVNFVTTSMLNHKSIGVFSHLARFLLTVSLEWQDNPFS
                     LFRVIENLDFLPYIPRIKYKNIILSEEKWILSDVDKKDMSTISQWKKFFDVPSLLYFHK
                     DDERLLIDLKNSLDVQWILKQNVDKLHFTRFDKIDGKNCEFIFGFENPRNSVYPHSVSE
                     KTVRRIENDFYKDYVKTFSSDWIYFKLYGINSSTMPELRENLLIFTDELLAEKLVSDFH
                     FVNYNDGGDGSIRLRFKIMNEDDFEKLRYRIIHWIDFLLNHYFCKDVSFNLYEREVERY
                     GGIGFLTVCERIFSIDSYLVLKLFSKKVLKVDDYLSVLHSIFIYIRLLGISPKQLLKLM
                     KDTFTQNIYRKSFKKVFPNNAKVIKEFKQYFEDQSKFDIFNEVFKSFSPIEKHFEYKND
                     MIHSLLHMHMNRIGIFSLNEKEYLYFVRYILEVLNNYEKYN"
     aSDomain        complement(7730..7930)
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_A1898_RS06085_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="1.90E-09"
                     /identifier="RREFam001.1"
                     /label="A1898_RS06085"
                     /locus_tag="A1898_RS06085"
                     /protein_end="221"
                     /protein_start="154"
                     /score="29.1"
                     /tool="antismash"
                     /translation="SEQSRDILIKKTALLEFIKKLTYKSEVSVLDLVQEIQTKSPNLET
                     QKIIDYLRNLIISEFLFTNLRK"
     gene            complement(8452..8556)
                     /locus_tag="A1898_RS06090"
                     /old_locus_tag="SAMEA2521606_01233"
     CDS             complement(8452..8556)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011225312.1"
                     /locus_tag="A1898_RS06090"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA2521606_01233"
                     /product="hypothetical protein"
                     /protein_id="WP_000432035.1"
                     /transl_table=11
                     /translation="MENTEFSLELDVTEVATEQDYVSSGVTSTGCCKN"
     gene            complement(8846..9709)
                     /locus_tag="A1898_RS06095"
                     /old_locus_tag="SAMEA2521606_01234"
     CDS             complement(8846..9709)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR01716"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000572848.1"
                     /locus_tag="A1898_RS06095"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA2521606_01234"
                     /product="XRE/MutR family transcriptional regulator"
                     /protein_id="WP_000570723.1"
                     /sec_met_domain="TIGR01716 (E-value: 4.9e-67, bitscore:
                     217.6, seeds: 14, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIEKMELGEFYKELRLARKLKQSDVACEGLTASQLSKFELGQSML
                     SADKLILAIQGINMNFDEFGHKLNNYQESPHMRIGRKVVDRFAHQDIAALEQLLEEVDQ
                     EQMAQTYRRLNAIVIKNALHSLDKSYPLTEEDSEFLTTYLYAIESWTWFELYLFCNTMP
                     FLSNQDLIFLSTSLLEKSKEFKELVHNRWYMKSGYLNIISELMERKLFSYVPIFEAELE
                     RMLRPYDVFEKVLWQFLKKMQIFLQTKGSNQKEIEHFIQSLQVLENPQLTALFELRLQQ
                     YKELID"
     gene            complement(10104..11275)
                     /locus_tag="A1898_RS06100"
                     /pseudo=""
     CDS             complement(10104..11275)
                     /GO_function="GO:0016616 - oxidoreductase activity, acting
                     on the CH-OH group of donors, NAD or NADP as acceptor
                     [Evidence IEA]"
                     /GO_function="GO:0051287 - NAD binding [Evidence IEA]"
                     /GO_process="GO:0000271 - polysaccharide biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1152: nucleotide sugar dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001017606.1"
                     /locus_tag="A1898_RS06100"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="nucleotide sugar dehydrogenase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MNIAVIGLGHVGLAYALLFASKYKVVAYDIDSVKINNLKKGILPS
                     KNEELMKFFCENNLNITFFDTFSEIKNNIDYYIIALPTDYDEKIGSFNTYEIEQTVSKI
                     LRVKPNGKIILKSTVPIGFSNKLKRLFDTKNIIFVPEFLREGCSIYDNLYPSRIVVGDE
                     TVEGRKIAELFLSISTHSTANIKNVMLVSPTEAEAIKLFSNTFLALRVAFLMN"
     gene            complement(11288..12037)
                     /locus_tag="A1898_RS06105"
                     /old_locus_tag="SAMEA2521606_01237"
     CDS             complement(11288..12037)
                     /EC_number="3.5.1.-"
                     /GO_function="GO:0019213 - deacetylase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PIG-L"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000069862.1"
                     /locus_tag="A1898_RS06105"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA2521606_01237"
                     /product="PIG-L family deacetylase"
                     /protein_id="WP_000069864.1"
                     /sec_met_domain="PIG-L (E-value: 9.7e-19, bitscore: 60.3,
                     seeds: 137, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSNNTKYIFLSPHLDDAIFSCGDYISKLTSEGEIVLVITIFSGYP
                     LSQQLQPSAKQFHKLCNLGKYPIEERKKEDRLACERLQCDFRHLSYYECLYRKDRNGNF
                     LYRHIYSELKNEDTLKNDIIKELLMHLDDKCVVYCPLSLGDHVDHVFVNSIGRALEFMR
                     YKVIYYEDFQYVSDSSMVSYMGKTKELKMYQEELDEKHYIDRISSILCYKSQILIIWKS
                     VEKLLNNIKELYLRNGAAYSIIFWIKK"
     gene            complement(12049..13587)
                     /locus_tag="A1898_RS06110"
                     /old_locus_tag="SAMEA2521606_01238"
     CDS             complement(12049..13587)
                     /GO_function="GO:0004066 - asparagine synthase
                     (glutamine-hydrolyzing) activity [Evidence IEA]"
                     /GO_process="GO:0006529 - asparagine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Asn_synthase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1177: asparagine synthase (glutamine-hydrolyzing)"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012386605.1"
                     /locus_tag="A1898_RS06110"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA2521606_01238"
                     /product="asparagine synthase-related protein"
                     /protein_id="WP_012386605.1"
                     /sec_met_domain="Asn_synthase (E-value: 6.9e-16, bitscore:
                     50.7, seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MENTLLNITGSFDMETRNLISYSLTDIFETDKIRIELLGEIYYKN
                     IKLELHEFAGLYKIYGISLIKNITGMFLIIIFDTKTKELKIFQDITTSYFNLYYTVYGG
                     VFYYSTSLKKVMKLSHVPVTLNNKKIQEFMRNGFILDSNTLVTEINKLEYFSYISVNNT
                     LRICGIDYNDSNNFTKEQVLKNWDSMLRESILRVYSEAGEANITLSSGFDSNYILYTLA
                     NYTNSSINAFCIGGEKGINEIPEVTKIAKFYGINLLVDTVMSQDLEYFPDIVWRLEGSL
                     FECGVILQYYLGRLLFQKGNTSILCGESADEIMTFKYHSVNYNQFCNDKQKSVYFSYSD
                     YPFYVTNSIVLKKNSLLLHSFGIHPRYPYKMSEIVEMSKKISDLNDKKEFHKKNCELRF
                     QDSVLDNINSVPGTTHLFSCLNIQTLVKIILYIFRYNSCMKIFNFRDKELIFFNKIVNG
                     LIQNIEENLEDDIERILKYLYICLFNEIFIIKNKVNFFDDVEFNQTLSEFLDKL"
     gene            complement(13616..14461)
                     /locus_tag="A1898_RS06115"
                     /old_locus_tag="SAMEA2521606_01239"
     CDS             complement(13616..14461)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001813546.1"
                     /locus_tag="A1898_RS06115"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA2521606_01239"
                     /product="hypothetical protein"
                     /protein_id="WP_001813546.1"
                     /transl_table=11
                     /translation="MRFYCEAYEVITEEKKVYFNDIELEVKYSSVEELFIICEKLLDKK
                     KVSFFYVDEKPLRYLLFDYIFLLVLAKKNIPILDGVSNKQVDPTLLHHFSLEIEKNFID
                     FCYKNMDLILKTQSISLCHREELIIVDVSDDSKFGVFYKRFRTLVDKNNGKYVCVYNFS
                     RVSDILQNWKNYCNRKFSVTFTESQFELFKLLYNQKNFKTISLLFGKKIVAGGIIYYSD
                     LTNIEYFCIFWWDSMFGKDSIGKYVYVEEISRCHFLDRNYSFCYGLQDYKSKLIKYFLE
                     "
     gene            complement(14481..16097)
                     /locus_tag="A1898_RS06120"
                     /old_locus_tag="SAMEA2521606_01240"
     CDS             complement(14481..16097)
                     /EC_number="7.-.-.-"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000288036.1"
                     /locus_tag="A1898_RS06120"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA2521606_01240"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_000288029.1"
                     /transl_table=11
                     /translation="MYTIIKSNIKKFSLLTIFIVAGQLLLIYAATINALVLNELIAMNL
                     ERFLKLSIYQMIVWCGIIFLDWVVKNYQVEVIQEFNLEIRNRVATDISNSTYQEFHSKS
                     SGTYLSWLNNDVQTLNDQAFKQLFLVIKGISGTIFAVVTLNHYHWSLTVATLFSLMIML
                     LVPKIFASKMREVSLNLTNQNEAFLKSSETILNGFDVLASLNLLYVLPKKIKEAGILLK
                     MVIQRKTTVETLAGAISFFLNIFFQISLVFLTGYLAIKGIVKIGTIEAIGALTGVIFTA
                     LGELGGQLSSIIGTKPIFLKLYSINPIESNKMNDIEPNEVNRDFPLYEAKNICYKYGDK
                     EILKNLNFCFQRNEKYLILGESGSGKSTLLKLLNGFLRDYSGELRFCGDDIKKTSYLNM
                     VSNVLYVDQKAYLFEGTIRDNILLEENYTDEEILQSLEQVGLSVKDFPNNILDYYVGDD
                     GRLLSGGQKQKITLARGLIRNKKIVLIDEGTSAIDRRTSLAIERKILDREDLTVIIVTH
                     APHPELKQYFTKIYQFPKDFI"
     gene            complement(16184..17059)
                     /locus_tag="A1898_RS06125"
                     /old_locus_tag="SAMEA2521606_01241"
     CDS             complement(16184..17059)
                     /EC_number="2.4.-.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000375706.1"
                     /locus_tag="A1898_RS06125"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA2521606_01241"
                     /product="glycosyltransferase family 2 protein"
                     /protein_id="WP_000375707.1"
                     /sec_met_domain="Glycos_transf_2 (E-value: 7.5e-31,
                     bitscore: 99.2, seeds: 256, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDRNIDQELVSIIIPTHNRYESLIRAVKSCLHQSYKNIEVIIIDD
                     NYSNVNLRNKIIHQFGYTNHRIKLILSNEDLGATNARNIGIKNSRGKYISFLDDDDEYM
                     PDRILKLMACFKKSRMKNLALVYSYGIIIYPNGTREEEKTDFVGNPLFVQMVHNIAGTS
                     FWLCKKEVLELINGFEKIDSHQDGVVLLKLLAQGYQIDIVREFLVNYYAHSKENGITGV
                     TQKTINADEEYYNYCRKYFNLLSFNERILVTKKYYSLNIKRLLLIGDKCKALKVIKKAR
                     EEKIFNEFLF"
     gene            complement(17052..18257)
                     /locus_tag="A1898_RS06130"
                     /old_locus_tag="SAMEA2521606_01242"
     CDS             complement(17052..18257)
                     /EC_number="2.4.-.-"
                     /GO_function="GO:0016757 - glycosyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1045: glycosyl transferase group 1"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001200043.1"
                     /locus_tag="A1898_RS06130"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA2521606_01242"
                     /product="glycosyltransferase family 4 protein"
                     /protein_id="WP_001200043.1"
                     /sec_met_domain="Glycos_transf_1 (E-value: 1.8e-35,
                     bitscore: 114.1, seeds: 63, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQYSCGKININIPDGYGDIKDIVFSAHIIVRYNNGHCGGIDPHII
                     GLCKKQIRRMSLYPILIIVSRDSKVIDDYKNLDIAYVDCTQCSNNFETALHVKNILKLL
                     KIQLIHCHGYSTNYFLYMLKKLDKNGFGKVKTVITCHGWVEYNLKKKFLTYFDFWTYSM
                     GDAFICVSETMKKRLESIIKNKKIVAINNGINVSNSDLDVVGVQDFKKEFCIPNNKKII
                     CYVGRLDPEKRPDRFLEFAEKLFLVREDVIFIMAGNGSMWAALKEKICHLKCRDNFRLL
                     GEIYPATIVYQISDLLYIPSDTEGIPMCVLESMSQGTPVLASNVGGLSEIIEHRVDGFL
                     FEKEDVEGVCACANFLLNDSEYLKYIGENSKSKIRKHFSVQKMFVETMRVYDELLEKSS
                     HG"
     misc_feature    complement(18211..18226)
                     /note="TFBS match to CsoR, Copper-responsive repressor,
                     confidence: weak, score: 20.19"
                     /tool="antismash"
ORIGIN
        1 atagcagatt gaaataagat gagaacaaat cgattgggaa agtaaaatta atttctataa
       61 atgttttagc aattgtttcg tactatttta gattcagtct actataacac attcagaaaa
      121 gagaaaaaag tctgttgatt ttgaccatca taaaaagact ggcaatccag tctcaaacat
      181 attttataga aattctccac taaatacttt cacgaatatt cagaagcatg acaaaggcaa
      241 ctagaagaaa tagcaataaa acaaagctaa ctgccagagt tccaaagctg gtagcaatgg
      301 ttaccaaagc tattgtaaat aagctaggta agacaaccgt aatggcaccg atagaagatt
      361 gaactgctcc cattgactcc tcaggtattt gtttaaagac gagttcttgc aatctaggag
      421 agagaatacc cgcgaaaaag gcatccaagg tactaaagat gagaatccag tcaaaacgaa
      481 ctgtggcaaa tcctactaga agaagcaact ggataacaag tgaggcatag agagctgttt
      541 ttatggaaat ggtatgttgc agatagccac tcataagact tcccaaaata agggctgata
      601 attctagtgt ggctaacaag gcaagagatt gaccagtttg taaattcaaa aagggctggt
      661 tccttaaaaa tagagtggaa ataggaaccg taacatttat cactgcttga ctagtagaga
      721 taataaacaa aaccaagagc accttattca tattccatat caatttcgat gattggagca
      781 aatgctggca aaaggatttt acagagagtc cttcttgata gctaatcgtt ttttctactt
      841 tcaagaggtc agtttttatg aagaggatac ctaaaaatgc gattaaaaag gtaagagcgt
      901 tcagtaagga aataaactgg atggatagaa tgcctagtaa gactcctcct aggatattac
      961 tgattgtttt cactaaacta acagttgact gtttaaatcc aatagcttct gccagatggt
     1021 cttgcccaat aattctaatg aaaatcggag tgagcatggc gcctgaaaaa taactcaatg
     1081 tgtcagacaa gaggttaagc agacaaataa aggttactag caacaaggaa aaagactgcc
     1141 ctgaaagcga tagggacact atagagtaaa gcaaaaattt tgtaaaacta atgactgtgt
     1201 atttcaagac acgatgatgt tgaaaatccg ccaaaactcc cagaaagatt tgtagaactt
     1261 ggggaagggt ttctgaaatc gtgataagta aaatcgccaa aggggcaaaa gacgcatctg
     1321 ccacataatt caggaaggcc agataaaaaa tcgtatcccc aagcgttgaa atccactggt
     1381 tgatagttaa ttgcctaaaa tctctatttt gaagaaatac tttcatcaca actccttctt
     1441 aagttcaaat gggaatcttt ccccagaaat agaccgcgat actactaaca accaaaatta
     1501 cagtaacatc aaaagctgac caataccgtt gtagactata tgcagcccaa taggccaata
     1561 aatggacttt gtcattctaa ataagactgc aaatataagt ccgccaccca tatagacgaa
     1621 aaagtctgtc aagacccaac cgtgattact aatgtgcgag accccaaata aaacagcgga
     1681 accaagtaca tctagccccc atttctttcc tttttccaga gctgtcatca ccaatccccg
     1741 atggattatc tcttcaaaaa tgggacctac aatcacagga tagaaaaaat acatcaaaaa
     1801 tgctgtagcc cctgtaaaag tcggagcagc atgttgataa gaaatttcat ttcgagtagg
     1861 tgggaaaaga aaaaaggtaa cgaaattcca aacaacaaaa gcaagcagag ctaggaagga
     1921 atagaaaaga taggatcctt taaactttct actattgatt ttctgccatt tccccgacca
     1981 aatcatagca ataagagcaa ataaaaccac aagaaaattc aacatcatat ccgacagata
     2041 ataggcaaag tcagatagcc cagtaacaag gtcactgcgt aaaactagag cactgaactt
     2101 ctggtcagca ataactagta gaaaaactat aataaagtag cggtgtgaga ttatcttttt
     2161 catatatcac ctttctaata tccaaatacc aataaagtaa caatgagtaa gaaactattc
     2221 catgaagcat gcagagctat agcccaatag atggatcggg tgtagcgaaa catcatacaa
     2281 aatatcaagc ccattccaaa atactttatg aaatctgtcg ttatccaacc atactgcaaa
     2341 acatgcatag cgccaaatat ggcagcggaa acaagaacat caagatagta tctcttaact
     2401 ttagataaac ttgtcatcaa aagaccacga caaacaacct cttctgatac aggtgcgata
     2461 atactagtat aaagtattcg cgtaacaaaa tagctaattc ctgttaaatt ggtggctact
     2521 tctacgactg tacttccatt ctgggtacga ggaaagatat aggttgttag atttgcccac
     2581 acgaacaata agaaaaaaga aagaaggaaa acacccaggt aagaccaacg aaactggaaa
     2641 cgaccacact ctttccaatg ttcacttttg acaaaagcaa ttgtagctat agttcccaga
     2701 ataagtacca ataaaacttg gaacacatag tacatattat cagacaaagc agccataaaa
     2761 tctaagtctg atgtgacatt aaaaatgagg taataagtca aaatcaacaa gccagttgct
     2821 aggtgaaatt tcacttcttt cattttcttc atcctattat ctcctataag agcctatttt
     2881 atatctaatt gcaaggactg gaggaataaa gttaaaattt caaaattctc tcagcttgta
     2941 gtctgtactc ttctaaaagt atagatagcc actattaaaa ctaatatcat atatatcact
     3001 gctatataag tataagataa atagattacc aatgtagaaa acaataatct tgatacgaca
     3061 tctcccaact ggaagtaagt aaccattcct ccaaatattg tagctagttt cgtttcatca
     3121 agattattaa atatgatagc tcctatttta ggatttaatg cactgacaaa tacactcgaa
     3181 agaaataatg ttaatactat aaaataaata ttttggtaat aaaacgcaat aaatgataat
     3241 aaaatagtca ttaaattcat tttcaataag ttctctatgg aaagattttt aaatttttta
     3301 ctaattagaa tcaaagttcc acctaaaatc cctccagaaa cagtactaat tcccaaaact
     3361 gaaattgttg ttgcagaact aataattgta agagcagaac ttttagaaag attcactaca
     3421 gctagtggta tgataatggc taagctccca ttaagaattg gaataacaag taatacagtc
     3481 ttcatattag tgagactaaa tagatgttta agcgaaagtt ttaagtttga aataatatca
     3541 gaaaacgtag ctttaaaatc aacttttgaa accttagtgg atggggtctt gtctatataa
     3601 aaattgttaa tttggctttt gatagctaat gttattagta aactaatagc gaatgttaga
     3661 gaatttataa gagctaagtg aaagaaacta agaaaagtga ttaaaaatgc ccctaacgac
     3721 tgatttacaa tgttcatggt agaagttgct gtttgcctaa acgccatggt ttcttcccta
     3781 tctgattttt tcactattcg attagaaatt ggatagaaaa gaccattttc aaattgcccc
     3841 aatgtatctg aaataagatt aactatacta gcaagtatta ctactaaaat ggattcctta
     3901 aaattcatga caacagccac taataaatat aaaattgtcc gtatccataa cgttttgata
     3961 atcattccca ctttattaag tgtcctatct gcaatgatac caaaaaatat tgtgaacaat
     4021 ataggtatag tctccgatat atttacgatt gagatagcca aattgctact cttaatctcc
     4081 gtcacataag tcatgagagc tataaaatat agtgtatctc caaagtttga tatcagatct
     4141 gaaaccaaga ctttcatata tagcttatta tttaaaattt ttttcatatg ttatccctat
     4201 atctacctta aaccctcact gcataaaaaa catttcagcc aaaggagaag catttcctgt
     4261 cctctgcgcc attagtgcaa gaactatccc agaaacccca tttaacaagc caaaatcaat
     4321 atactctatc acttcatcat aattcacacc cctaaaatat atatcacgtt ccacaaatat
     4381 gtattcagaa tcagtggctt tatttactat ttccttaaat aaattatcag aaatagcttt
     4441 aaactgtgat tcccctgtgt ctaaatacat caagttgaac aaaagcatta tcccagagcg
     4501 accatgacaa attgcgttat ttaaaatttc actactatta aggtaataaa tagatgagtg
     4561 gaatacatca gtagctaact cttgtaattt tgggatgtca attattttag atatattata
     4621 tagtactctt gccattccaa gactaccata acaccaactt aaattatatt cgaatttctc
     4681 actttctacc tcagcactta ctctaccatt ccagccaata atcttgccaa tcttattagt
     4741 ttgaaaagtt ttttcatagt aactcaaacc cttttttagc gaaattaaat actctggcat
     4801 gttgaatttt ttaaacccta atgctaaaac atatagtggt cctaatatac catgagctac
     4861 acctaggttg atatagccat tggggaattt tctctttaat ttttcatttg gcatatattc
     4921 cggataaata gttggcttat tatttattac tcctgctaaa taatttaaaa ctccttttaa
     4981 taatagttcc tgattagaag tcaatttatc cttgctaaga aaatactttc ctacactaga
     5041 aactccttgg attacatcaa tatattcttc tttaacttta ttggattttt ttatttcact
     5101 tagcctatct ctagttaaag atactaaaat tgtttcaagt gtctctagca atttactata
     5161 ttctttactc ctcttaggta acaatttcaa ggcatataca tagccagaaa atccatagca
     5221 cattgatata ttattacgac tgttcaactt aatcgacttt aacagttcat gtaaatagta
     5281 gtttactcta ttgtagagca acttagaatg ctcgttatca tcgcaattag ctaatctata
     5341 tgataaatat atgattatgc tggggtattc cgacaagtaa cttctatttt ccgtatagca
     5401 cgagcgctgt agtaaatcaa taatattatt gtctaacact agactatcta ctttattgat
     5461 gatttcatca tacttcttaa ttatatttct cataattatt taatacctct aaaatatacc
     5521 tcacaaaata aagatattcc ttttcattta aggaaaatat tcctattcta ttcatgtgca
     5581 tatgaagcaa actatgaatc atatcatttt tatattcaaa atgtttctcg ataggtgaga
     5641 agcttttaaa aacttcattg aaaatatcaa atttactttg atcttcaaaa tattgtttga
     5701 attcctttat tacttttgcg ttattgggaa acaccttttt aaaactttta cgataaatat
     5761 tttgagtaaa agtatccttc atcaatttaa gtaattgttt tggagatatt cccaatagtc
     5821 ggatatatat aaaaattgaa tgtagaacag ataaataatc atcaactttt aatactttct
     5881 ttgaaaacaa ctttaaaaca agataactat caatagaaaa tatcctctca catactgtta
     5941 aaaagccaat acctccatat ctctcaacct ccctctcata taaattaaaa cttacatctt
     6001 tacaaaaata atgatttaat aggaaatcta tccaatgaat aattcgatat cttagctttt
     6061 caaaatcatc ttcgttcata attttaaacc ttaatctaat agaaccatcc ccgccatcat
     6121 tataatttac aaaatgaaaa tcactaacta atttctcagc taaaagctca tcagtgaata
     6181 taagaagatt ttctcttagt tcaggcatcg ttgaggagtt aattccatat aatttgaaat
     6241 atatccaatc gctcgaaaac gtttttacat aatctttata aaagtcattt tcaattcttc
     6301 tgacagtttt ttcacttact gaatgagggt atacactatt tcgaggattt tcaaatccaa
     6361 agataaactc gcaattttta ccatcaatct tatcaaaacg cgtaaaatgt aatttatcaa
     6421 cattttgttt taaaatccat tgaacatcta aactattctt taggtcaatc agtaaacgct
     6481 catcatcttt atgaaagtat agaaggctag gtacatcaaa aaattttttc cactgactaa
     6541 tagtagacat atctttttta tcgacatctg ataaaatcca cttctcttca cttaaaataa
     6601 tattcttata tttaattcta ggaatataag gaaggaaatc aagattctca attaccctaa
     6661 atagagaaaa tggattatct tgccactcta acgaaactgt taacaaaaat ctcgctaaat
     6721 ggctaaaaac tccgatagat ttatgattca gcattgaggt tgttacaaaa ttaacaatca
     6781 agtctgttcg taagtctcta aaatatagtt tgtaatgctc attcactctc tcaacaccca
     6841 ctactaagaa atctaattct aacgagtcaa tatcaaagtc atcttcataa gatagtaata
     6901 actttttaga atgtccatgg tgagaagaca taacatttaa atttttatta tcacttggaa
     6961 attctattaa ttctacatta tcaaccctcg aatctaattc tatattagaa tttagaaaat
     7021 atgaagcaaa tctaccaata gactttccta tcatatcact cccagtattt ggcacaattg
     7081 atataacagg ttgttctcca aaattcttca tttcacaata caactcgaac tgattcacag
     7141 caaatctatc caaatttgga tacaataatt caggcggaat atttgatata tcaatttcct
     7201 ttttattatt tttcactgct ttaaagattt ctttacttag ataagacaaa aaagtttgtt
     7261 ctgcaacact tgataatata ctataaggtt ccaaattttg ttttggtatc cccaacccta
     7321 acttactatc cagtagttgc ttaataggaa cttcaacata ctctccgtat ttttcgacaa
     7381 atttttctgt gtacgagatt aattccttat ttcgataatc tttacccaga ttaattctcg
     7441 aaataaagtt aacgaagtcc tccaatgtct tttttaaatc tttgggtaat agcgaatcat
     7501 aactattcac taagtcaacc ttcagatagc gctgtttttc ttcattaaaa atatgagaca
     7561 ttttttcaca aatttcagca tattgaagaa taccttctcc taactctgat tttgaatact
     7621 tctcgatgca tgatttaagt tgtaacaaat cagtagttaa ttttgtttgc tcattaatag
     7681 aacttaaaat ataaattaaa ttatctaaac aattgtgatt tattacaacc tttcgtaagt
     7741 ttgtaaataa aaattcactg ataattaaat tacgtaaata atcaataatt ttctgtgtct
     7801 ccaaattagg agacttagtt tgaatttctt gtaccaagtc taatacactt acttccgatt
     7861 tatatgtcaa ttttttaata aattctaaaa gggcagtttt cttgataagt atatctctac
     7921 tctgctcgga aacaccccaa tagttgatat tattcaattg atacttatct gatagctcca
     7981 gtactttttg attccactgt aaatgtaatt gcaataaaac tgaatcttca ttttctaaca
     8041 tcatacaaag cgaactaatc cactctccac taacagacac ttttttacta taattctctc
     8101 taatctgttg agggtatgaa acttttgaaa aagaaccaac accaactgaa ctaaacaatc
     8161 caaatggagt tgctcttgta agcgacctct ttgcataatt tctaaacgta gaattttgat
     8221 atattttttc cttagttaat tcattaaaaa atcgtggatt cgccaccatc aacatctctt
     8281 gaaatatttt gctatcaaaa aatatttcaa gattattttc attaagtttt tctatcagta
     8341 tagaatcatt aacgcattgc ctgtaaatat aattatcttt tattttaaac atatttttct
     8401 tttaattaaa aagcaagtac ttgtacctgc tttataaaat caattattaa attagttttt
     8461 acaacaacct gtagatgtaa caccactaga aacataatct tgttcagttg caacttcagt
     8521 cacatcaagt tccaatgaaa attctgtatt ttccataata aacgattcct cctccaatta
     8581 tttttactta taaaccactt ctgcgaccta ggatttgctt caaatgtttt acaaggacag
     8641 tataacacgg aaattggctt attttagaaa atcgcatatt tgatattttt tcttatagaa
     8701 atttcagatt tgcgattttg gtagatttga ttatttccct ggtataataa agttattact
     8761 aatgaggagg gaagtaatat gaagaaacaa gttttaacat tattgacgat cgttgctgat
     8821 attattatct ttttcccatt tctaactaat cgataagctc tttgtattgc tgcaaacgca
     8881 attcaaaaag ggctgtcaat tgtggatttt ctaatacttg cagagattgg ataaagtgtt
     8941 caatctcttt ttgattgctt cctttggttt gaagaaaaat ctgcattttc tttaaaaact
     9001 gccacaatac tttttcaaaa acatcgtatg gacggagcat gcgctccagc tcagcttcaa
     9061 agattggaac ataagaaaat agcttgcgct ccataagttc tgagatgata ttaagataac
     9121 cacttttcat ataccatcga ttgtgtacta actctttaaa ttccttggat ttttcgagta
     9181 aggaggttga taaaaagatc agatcttgat tgctcaagaa gggcatagta ttgcaaaaaa
     9241 gatagagttc aaaccaggtc caagactcaa tagcgtagag gtaggtagtc aaaaactcgc
     9301 tatcctcctc tgttagcggg tagcttttat ctaaggaatg gagtgcattt ttaatcacaa
     9361 tggcattcaa acgacgatag gtctgcgcca tctgttcttg atcgacttcc tccaatagct
     9421 gctctaaagc agctatatcc tgatgggcaa agcgatccac aacctttcga ccgattcgca
     9481 tatgtggaga ttcttgatag ttgttgagct tgtgcccaaa ctcatcaaaa ttcatattga
     9541 tcccttggat ggctaatatg agcttatctg cagatagcat agactgtcct agttcaaact
     9601 tggacaactg agaagctgtt agaccctcac aggccacatc tgactgctta agttttctcg
     9661 ccaagcgcaa ttccttgtaa aattctccca gttccatttt ttcaatcatc ctaccacctc
     9721 ctagcttttg catattatat cattatttgt gttcatttgt caaaacattc tgacactttg
     9781 gtgattgaaa aagccagcct taagctgact ctaaaaggac cgagccttgt acaatacaga
     9841 actcaatcct cgttctaaat agaatgtcta acttttttgg gcagtacacg agcttgggga
     9901 acagccactg gaacgatgag gtgtgagctc aaaatatcct ccagttatgt ttttcctaat
     9961 agtataccgg aagagtgaaa ggattttata atggagcggt tacaaagaac ctactttcta
    10021 ttaaacagta tactatgaaa atgtgaaaat ttaacatttt tttgtacaaa ttttataaat
    10081 tattgccttt ttaatatcaa tagttaatct cttatccaga tcccccttgt gtaaacttta
    10141 tctttataag cttcaaggtc cctatcccat ctatttgcaa caattagatc actttgtttt
    10201 gtaaatagtt caaaattctt ttcaaaaatt acgttatcta tactaacgtt taaatttggt
    10261 tcatatacta aaatttttat accgacaatc aatagttcat taattatact taaaatagct
    10321 gactctttgt aattatctga attatatttc atccccaatt tatatattcc tactatcttt
    10381 ggctttcgtt ccaatatttg tttaactatg aactgttttc tatttgtgtt tgaaatatca
    10441 atcgcttcta tcactggggc atttatttct ataaattctt tttttaattg tttagtatct
    10501 ttgggaagac aatatcctcc aaatccaaaa gaaggattat tataaaaatt tccaattctt
    10561 ggatctaaac aaacaccttt tattacaact tcagcattta aacttctcct ctcagcaaaa
    10621 gaatctagtt cattaaaaaa gcaacacgga gagctaagaa tgtgttagaa aaaagcttaa
    10681 ttgcttctgc ttcagtagga gaaactaaca taacattttt aatattggca gtactatgag
    10741 tactaatcga aaggaacaac tctgcaattt ttcttccttc aactgtctca tctccaacaa
    10801 ctatgcgact tggatataaa ttatcatata tagaacaacc ttctctcaaa aattcaggga
    10861 caaaaatgat attttttgta tcaaacagcc tttttaattt gtttgaaaag ccgatcggaa
    10921 ctgttgactt taaaataatc tttccattag gttttaccct cagaatcttc gataccgttt
    10981 gttcgatttc atatgtatta aaactaccaa ttttctcatc ataatctgtc ggaagcgcaa
    11041 taatataata atcaatatta tttttaattt cagaaaatgt atcaaaaaaa gtaatattta
    11101 agttattctc gcaaaaaaac ttcataagct cttcattttt agatggaaga atgccctttt
    11161 ttaaattatt tatttttaca gaatctatat catatgcaac aactttatat ttagatgcaa
    11221 atagtaacgc gtaggccagc ccaacatgcc ccaaaccaat tactgctata ttcataaaac
    11281 tacttcctta tttcttaatc caaaatataa tagaataagc tgccccattc cttaaataca
    11341 actctttaat attgtttaaa agtttttcaa ctgatttcca gattatcaaa atctgagatt
    11401 tatagcacaa tattgatgat attctatcaa tataatgttt ttcatcaagt tcctcttgat
    11461 acatttttaa ttctttagtt tttcccatat aactaaccat actactatca cttacatatt
    11521 ggaagtcctc ataatatatt actttataac gcataaattc aagcgccctt ccaatactat
    11581 tcacaaaaac atgatcaaca tggtcaccaa gtgaaagcgg acaatatacg acacatttgt
    11641 cgtctaaatg cattaacagc tcttttatga tatcattctt taatgtgtcc tcatttttta
    11701 attcactata gatatgacgg tatagaaaat tgccatttct atctttccta tagagacatt
    11761 catagtacga taagtgtcta aaatcacatt gtagacgttc acaagctaac ctgtcttctt
    11821 tcttcctttc ttcaatcgga tatttcccaa ggttacacaa cttatgaaat tgcttagcag
    11881 agggctgtag ctgttggctc aaagggtaac cagaaaatat agtaataaca agtacaattt
    11941 ctccttctga agttaatttt gaaatataat caccacagga aaaaattgcg tcatctaaat
    12001 gtggagataa aaagatatac ttagtattgt tactcataac cattccctct acaatttatc
    12061 taaaaactca ctaagtgtct gattaaattc cacatcatca aaaaaattca ccttattctt
    12121 aataatgaat atttcgttaa ataaacatat atataaatat ttcaatatcc tttcaatatc
    12181 atcctctaaa ttctcctcaa tattttgtat cagcccattt acaatcttat taaaaaagat
    12241 aagctcttta tctctaaaat taaatatttt catacaactg ttgtatcgaa aaatatataa
    12301 aataattttt actaatgttt gaatatttaa acaactaaat aaatgagttg tacccgggac
    12361 actatttatg ttatcaagaa cactatcttg aaacctcaac tcacagttct ttttgtgaaa
    12421 ttctttttta tcgtttagat ctgatatttt tttagacatt tcaacaatct cagacatttt
    12481 atatggatat ctaggatgaa tgccaaaact atgcaaaagt aggctatttt tctttaaaac
    12541 aattgaattt gtaacataaa atggatagtc ggaataacta aaatatactg acttctgttt
    12601 atcattacaa aattgattgt agttcacaga atgatactta aaagtcatta tttcatccgc
    12661 tgactcgcca caaagaatac ttgtgttccc tttttggaac aacaacctgc ctaaatagta
    12721 ctgcagtatg acaccacatt caaagagact tccttccaat ctccatacta tatcgggaaa
    12781 atattctaaa tcttggctca ttacagtatc aactaataaa tttataccat aaaattttgc
    12841 aattttagtt acttcaggaa tctcattaat tcctttttct cctcctatgc aaaatgcatt
    12901 aattgaagaa ttcgtataat tcgctaatgt atataatata taatttgaat caaaaccaga
    12961 tgatagtgta atattagcct ctcctgcttc actatacact cttaatatag attcacgtag
    13021 catagagtcc caattcttta atacttgttc tttagtaaaa ttgtttgaat cattataatc
    13081 aataccacat atacgaagag tattatttac agaaatgtaa gagaaatatt ctaatttatt
    13141 aatttcggtt actaaagtat ttgaatctaa aataaatcca tttctcataa attcttgtat
    13201 ttttttgtta tttaaggtaa cgggaacatg agataacttc atcactttct ttaaagatgt
    13261 actataatag aacacacctc cataaacagt atagtataaa ttaaagtatg aagtcgttat
    13321 atcttgaaaa atttttaatt cttttgtctt cgtatcaaaa attataatta aaaacattcc
    13381 ggtaatattc tttattaagc taattccata aatcttatac aatccagcga attcatgcaa
    13441 ttccaacttt atatttttat aataaatttc tccaagaagt tcaattctta ttttatctgt
    13501 ttcaaagata tcagttaaag aataactaat tagattccta gtttccatat cgaagcttcc
    13561 tgtgatattc aataaagtat tttccatatt tctttatctc tctcgaatag attaactatt
    13621 ctaaaaaata tttaataagt ttacttttat aatcttgtaa accataacaa aaagaataat
    13681 ttctatctaa aaaatgacat ctactaatct cttctacata tacgtatttt ccaatagaat
    13741 ctttcccaaa catactatcc caccaaaaaa tacaaaagta ttctatatta gtaagatcgc
    13801 tataatagat aattcctcca gcaacaattt tttttccaaa tagcaacgaa attgttttaa
    13861 aatttttttg attatataaa agcttaaata attcaaattg gctttcagta aacgtaaccg
    13921 aaaattttcg attgcaataa tttttccagt tttgcagtat atctgaaaca cgactgaaat
    13981 tataaacaca aacatatttt ccgttatttt tatcaaccag tgttctaaaa cgcttgtaaa
    14041 aaacaccaaa tttagagtca tctgaaacat ctacaataat aagctcttct ctatgacaca
    14101 aagatatact ttgagttttt aggatgagat ccatattttt atagcaaaaa tcgataaaat
    14161 tcttttcaat ttccaaagaa aagtgatgca gcaacgttgg atcaacttgc ttattggaaa
    14221 ctccatctaa gattgggata ttttttttag ctagaactag tagaaatata tagtcaaata
    14281 acagatacct taagggtttc tcatctacat aaaaaaatga tacttttttc ttatctaata
    14341 atttctcaca tattataaac aattcttcga cagaggaata cttaacttct aactcaatat
    14401 cattaaagta tacttttttc tcttcagtaa ttacctcata agcttcacaa tagaatctca
    14461 tgtttccctc ccctatattc ttaaataaaa tcctttggaa attgatatat cttagtaaaa
    14521 tattgtttaa gttccggatg cggagcatgg gtaacaataa tgacagtcaa atcctctcta
    14581 tctaatatct tacgttcaat cgctaacgaa gttctcctat cgatagcaga agttccctcg
    14641 tcaattaata ctattttctt atttctaatt agccctctag ctaaagtaat tttttgtttc
    14701 tgccctcctg acagtaatct cccatcatca ccaacataat aatctaaaat gttattagga
    14761 aaatctttta cactcaaacc aacttgctct aaagactgta gtatttcttc atcagtataa
    14821 ttttcttcca ataaaatatt atctctaatc gtaccttcaa acaaataagc tttttgatct
    14881 acatatagaa cattcgaaac catatttaaa taggaggttt tttttatatc atccccgcag
    14941 aatcgcaatt ctccactata atctctcaaa aagccattca ataattttaa taatgtagat
    15001 ttcccgcttc cactttcacc taaaattaaa tacttttcat tacgttgaaa acaaaaattt
    15061 aagtttttta atatttcttt atctccatac ttatagcaaa tattttttgc ttcatataac
    15121 ggaaaatctc tattcacctc atttggttcg atatcattca ttttatttga ctcaattgga
    15181 ttaattgaat acaattttaa aaaaataggc ttcgtaccaa taatagagga taattgacct
    15241 cctaattcac ctagcgctgt aaaaataaca cctgttagtg ctcctattgc ttcaatagta
    15301 ccaattttca ctattccttt tattgcaaga tagcctgtta aaaaaacgag agatatctga
    15361 aaaaaaatat tgagaaagaa gctaatagcg cctgctaacg tttctacagt tgtctttctt
    15421 tgtataacca tctttaataa aattcctgct tctttaattt tcttaggcaa tacatataaa
    15481 agattcaagg acgctaacac atcaaatcca ttcaatatag tctcactaga ttttaaaaaa
    15541 gcttcatttt ggttagttaa atttagacta acttctcgca ttttcgatgc aaagattttt
    15601 ggtacaagta gcataatcat taatgaaaac aaggtggcta cagtcaatga ccaatgatag
    15661 tgattaagag tcacaactgc aaatatagta ccagaaattc cttttattac taaaaaaagt
    15721 tgtttaaaag cctgatcatt taaagtctga acgtcattat ttagccacga aagatatgtt
    15781 cctgatgatt tactatgaaa ttcttgatag gtagagttag agatgtctgt ggcaactcta
    15841 tttcgaatct ctagattaaa ctcttggatc acttcaacct gataattttt cactacccag
    15901 tcaaggaata ttatcccaca ccagacaatc atttggtaga ttgacaattt caaaaaccgc
    15961 tctaaattca tcgcaattaa ttcattcaac accagagcat taatagttgc tgcataaatt
    16021 agcaataatt gaccagcaac aataaatatc gttaataaac taaatttttt tatatttgat
    16081 tttataatag tatacacaat agtttctcac tttctaaatt ttaattgaac atagttgtca
    16141 tatatacaat agaaaaaacc aaaatgatat aataacatat atttcaaaaa agaaattcgt
    16201 taaaaatttt ttcttctctt gccttcttga ttacttttaa agccttgcat ttgtctccta
    16261 ttaatagtaa ccgctttatg tttaaagaat aatatttctt tgtaaccaat attctctcgt
    16321 tgaaactcaa taaattaaaa tatttcctac agtaattata atattcttca tctgcattaa
    16381 ttgttttttg tgtcactcca gtgataccgt tttctttact gtgagcgtag taattcacca
    16441 agaattctcg cactatatca atttggtatc cttgagcaag tagttttaat aaaacaacac
    16501 cgtcctgatg tgaatctatt ttctcaaaac cattaattaa ttctagcacc tcttttttac
    16561 acaaccaaaa tgacgtacct gctatattgt gaaccatttg aacaaacaag ggatttccaa
    16621 caaaatcggt cttctcctct tctcgtgtac catttggata aattattatt ccataactat
    16681 aaactaaagc taaattcttc attctactct ttttaaaaca agccatcaac tttaaaattc
    16741 gatctggcat atattcatca tcatcgtcta aaaatgatat atacttacct ctagaatttt
    16801 tgatacctat gtttctggca ttagttgcac ctaaatcttc attacttaaa attaacttaa
    16861 ttctatgatt ggtatagcca aattgatgga taattttatt tcttaaattt acattactat
    16921 aattatcatc aataattata acttcgatat ttttataact ttgatgtaaa caacttttca
    16981 cagctctaat cagagattca tacctattat gtgttggtat tataatactt actaattctt
    17041 gatctatatt cctatccatg actactcttc tctaataatt catcatatac tctcatggtt
    17101 tctacaaaca ttttttgcac agaaaaatgt tttcttattt ttgatttact attctcacct
    17161 atatatttca aatactcaga atcattgagt aaaaaattag cacaagcaca cactccctca
    17221 acatcttcct tctcaaataa aaatccatca accctatgtt caataatttc acttaacccg
    17281 ccaacattac tagctaaaac cggagttcct tgtgacattg actctaaaac acacataggt
    17341 attccttctg tatcagaagg aatatacaat aaatccgata tttggtaaac tatagtagct
    17401 ggatagattt caccaagtaa cctgaaatta tctctacatt tcaaatggca aattttttct
    17461 ttcaaagcag cccacatact accatttcca gccataataa aaatcacatc ttctctgact
    17521 aaaaataatt tttctgcaaa ttcaaggaat ctatccggcc ttttttctgg atccaacctt
    17581 ccaacataac aaatgatttt tttgttattt ggaatacaaa attctttttt aaagtcttga
    17641 acacctacta catctaaatc gctatttgat acattaattc cgttatttat tgcaactatc
    17701 ttcttatttt ttattatact ctccaatctt tttttcatag tttcagatac acaaataaaa
    17761 gcatctccca tagaatatgt ccaaaaatca aaataagtca agaatttctt ttttaagtta
    17821 tattcaaccc atccatggca tgttatcact gtcttaacct ttccaaatcc attcttgtca
    17881 agttttttta acatatataa aaaataatta gttgagtagc catgacagtg tataagttgg
    17941 atttttaata attttaaaat atttttaacg tgtaaggcag tttcaaaatt atttgaacat
    18001 tgagtacaat caacataggc aatatctaaa tttttataat catcaataac ctttgaatct
    18061 ctagatacga ttatcaaaat aggatataga gacatccttc tgatctgctt tttacaaagt
    18121 ccaattatat gcggatctat acctccacaa tgtccattat tatacctaac tataatatga
    18181 gccgaaaaca ctatatcctt aatgtctcca tatccatcag ggatattaat atttattttt
    18241 ccacaactat attgcattgt aaccatctcc ttaaacgacg cattatgata tttgatagag
    18301 aaatttttat gaataactca ataattttat agtaaatcat gcttatatct caaagatacc
    18361 tattttctct tgtctcgacc ttctccaaag aa
//
