LOCUS       NZ_FHRS02000011        17988 bp    DNA     linear   CON 12-DEC-2024
DEFINITION  Streptococcus pneumoniae strain GPSC18 substr. ST1797
            ERS455146SCcontig000011, whole genome shotgun sequence.
ACCESSION   NZ_FHRS02000011
VERSION     NZ_FHRS02000011.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1
  CONSRTM   Pathogen Informatics
  TITLE     Direct Submission
  JOURNAL   Submitted (08-FEB-2016) WTSI, Wellcome Trust Sanger Institute, CB10
            1SA, United Kingdom
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_900055005.2-RS_2024_12_12
            Annotation Date                   :: 12/12/2024 02:43:55
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.9
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 2,241
            CDSs (total)                      :: 2,189
            Genes (coding)                    :: 2,009
            CDSs (with protein)               :: 2,009
            Genes (RNA)                       :: 52
            rRNAs                             :: 2, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1, 1 (5S, 16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 45
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 180
            CDSs (without protein)            :: 180
            Pseudo Genes (ambiguous residues) :: 0 of 180
            Pseudo Genes (frameshifted)       :: 73 of 180
            Pseudo Genes (incomplete)         :: 93 of 180
            Pseudo Genes (internal stop)      :: 57 of 180
            Pseudo Genes (multiple problems)  :: 36 of 180
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 17:31:24
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 46451
            Orig. end                         :: 64439
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            FHRS02000011.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..17988
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="terpene-precursor"
                     /region_number="1"
                     /rules="(PT_FPPS_like and not PT_HPP)"
                     /tool="antismash"
     cand_cluster    1..17988
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(PT_FPPS_like and not PT_HPP)"
                     /kind="single"
                     /product="terpene-precursor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..17988
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="True"
                     /core_location="[10000:10876](+)"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..10876
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
     gene            232..1491
                     /locus_tag="A1898_RS05970"
                     /old_locus_tag="SAMEA2521606_01210"
                     /pseudo=""
     CDS             232..1491
                     /GO_function="GO:0016765 - transferase activity,
                     transferring alkyl or aryl (other than methyl) groups
                     [Evidence IEA]"
                     /GO_function="GO:0030170 - pyridoxal phosphate binding
                     [Evidence IEA]"
                     /GO_process="GO:0019346 - transsulfuration [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018365067.1"
                     /locus_tag="A1898_RS05970"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA2521606_01210"
                     /product="O-acetylhomoserine
                     aminocarboxypropyltransferase/cysteine synthase family
                     protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MTCDFKFETLQLHAGQVVTPATESRAVPIYQTTSFVFDDT"
     gene            1587..2861
                     /locus_tag="A1898_RS05975"
                     /old_locus_tag="SAMEA2521606_01211"
     CDS             1587..2861
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001002592.1"
                     /locus_tag="A1898_RS05975"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA2521606_01211"
                     /product="DUF2130 domain-containing protein"
                     /protein_id="WP_001002635.1"
                     /transl_table=11
                     /translation="MNEIKCPNCGEVFTVNESQYAELLSQVRTAEFDKELHDRMRQELA
                     LAEQKAMNEQQTKLAQKDQEIAQLQSQIQNFDTEKELAKKEVEQTSHQALLAKDKEVQA
                     LENQLATLRLEHENQLQKTLSDLEKERNQVKNQLLLQEKENELSLASVKQNYEAQLKAA
                     SEQVEFYKNFKAQQSTKAIGESLEQYAESEFNKVRSFAFPNAYFEKDNKVSSRGSKGDF
                     IFRECDENGVEIISIMFEMKNEADGTEKKHKNADFYKELDKDRREKNCEYAVLVTMLEA
                     DNDYFNTGIVDVSHEYEKMYVVRPQFFIQLIGLLRNAALNSLKYKQELALVREQNIDIT
                     HFEEDLDAFKLAFAKNYNSASTNFGKAIDEIDKAIKRMEEVKKFLTTSENQLRLANNKL
                     EDVSVKKLTRKNPTMKAKFEALKGE"
     misc_feature    1629..1640
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: medium, score: 19.59"
                     /tool="antismash"
     gene            2873..6058
                     /locus_tag="A1898_RS05980"
                     /old_locus_tag="SAMEA2521606_01212"
     CDS             2873..6058
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012512660.1"
                     /locus_tag="A1898_RS05980"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA2521606_01212"
                     /product="hypothetical protein"
                     /protein_id="WP_001813554.1"
                     /transl_table=11
                     /translation="MEDDLNYENLMDDVTEAIKKFNLVIFIGAGVSIAQGYPNWNNYIE
                     HLIKYWQGQVLSVSGEKRLGREHHVVFDLISKSSISNKRKVDLVNYELKKVFGEDFEKR
                     RLDFEKGYFKNLLPYSIVNQTVESLASLNAIFITSNYDYEIENHIKRLKNAVVTINDLN
                     EFTKNKNGKLQFGDVLHIHGTPDCDVKYFVSSSADYSKTYLKNRENFENLVTWFKETKP
                     TVLFIGAGLEEDEILSLLCKDSKNYALMKSENTGNQRVDEHYRGVVEGFFSSENHTQII
                     WYGDEFEKLPLFVKKLVADINEKLGTHDFYNQWNNLLNPSINQEEYNKNLDSISNDFKY
                     LSSVLDKVIENDNNQLDQLMLNALLRSETLTVIKKNFVLVFWKFIVKNIEKLSDNEWDV
                     IYKIIYEGSQNYFIDDVFFVYNYAIDNKISSFTNNNKLNELREIISKDGYIVNSNFNKD
                     KTLLGYWLVSAFEQQNRDLYIKEDSEVEVNLNYECVNKLMSILNNPEFLSYNYYSIEHQ
                     LKEYDVVKFLYELVKSKKLFIEEEKFLESDSEDLISTILIQKLLVQLDNEINLDLEFIK
                     RLIDKIDFSNIHFGEELNTFIKEHRSIIREKNIEIPKKPYRNWISSLEGGFVSQFSYLT
                     QENLVEYDESRVLEILVNAEKEQRGSSFLEEKTINETENFFITVLKESNEISKKVSDLL
                     KNHIDDLYPKYKRLYVKIISFPEIEENLRKIVREKYLKRFNKESFDSNDRKFFEYHIKQ
                     QNTDIDIFEKLLSINVNELSTPKGDNKQLDILHFINSEMGSYFQCLISLFINHSSYRDV
                     IIQIINSVTDTDYREFAQGILLNEYNPNRINVTYNTFLGFAYYHSTITIEAADVFTDVV
                     RDILNKKIEDNQILNKVYLVALERVDPTIESFSLSKNNYSQMINIIFTGDYEFRYSKEW
                     LGALFKFDSSANYLVTIFYLLYNENLKKNRFALFIEELSDYLTTYNQKLSLRGMNYKLN
                     HEELNNFDLLKKMFLKLMETDKIENDIFYLDGIKSILPLLSLDDRRNVLQHIQKQNNCP
                     PPEIEELQRIIVN"
     misc_feature    6137..6146
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 16.22"
                     /tool="antismash"
     gene            6159..7037
                     /gene="truB"
                     /locus_tag="A1898_RS05985"
                     /old_locus_tag="SAMEA2521606_01213"
     CDS             6159..7037
                     /EC_number="5.4.99.25"
                     /GO_function="GO:0003723 - RNA binding [Evidence IEA]"
                     /GO_function="GO:0009982 - pseudouridine synthase activity
                     [Evidence IEA]"
                     /GO_process="GO:0001522 - pseudouridine synthesis [Evidence
                     IEA]"
                     /GO_process="GO:0009451 - RNA modification [Evidence IEA]"
                     /codon_start=1
                     /gene="truB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006145474.1"
                     /locus_tag="A1898_RS05985"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA2521606_01213"
                     /product="tRNA pseudouridine(55) synthase TruB"
                     /protein_id="WP_001013254.1"
                     /transl_table=11
                     /translation="MNGIINLKKEAGMTSHDAVFKLRKILGTKKIGHGGTLDPDVVGVL
                     PIAVGKATRMVEFMQDEGKIYEGEITLGYSTTTEDASGEVVAETPVLSPLDEKLVDEAI
                     ASLTGPITQIPPMYSAVKVNGRKLYEYARAGQEAERPERQVIIYQFERTSPISYDGQLA
                     RFTFRVKCSKGTYIRTLSVDLGEKLGYAAHMSHLTRTSAAGLQLEDALALEEIAEKVEA
                     GQLDFLHPLEIGTGDLVKVFLTPEEATEVRFGRFIELDQTDKELAAFEDDKLLAILEKR
                     GNLYKPRKVFS"
     gene            7298..7600
                     /locus_tag="A1898_RS05990"
                     /old_locus_tag="SAMEA2521606_01215"
     CDS             7298..7600
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000985087.1"
                     /locus_tag="A1898_RS05990"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA2521606_01215"
                     /product="bacteriocin immunity protein"
                     /protein_id="WP_000985092.1"
                     /transl_table=11
                     /translation="MMRNEFRERVEQLLQQKEINENSELSHLFRLAIQNLDRNEKYQTI
                     MANLSQGLSLYLMTHHYQAPKSVIDFGLWIAKAPSQERGRLAFLQMLAQTLQGFR"
     misc_feature    complement(7654..7668)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence:
                     medium, score: 22.39"
                     /tool="antismash"
     gene            7708..8346
                     /gene="udk"
                     /locus_tag="A1898_RS05995"
                     /old_locus_tag="SAMEA2521606_01216"
     CDS             7708..8346
                     /EC_number="2.7.1.48"
                     /GO_function="GO:0004849 - uridine kinase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="udk"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001181378.1"
                     /locus_tag="A1898_RS05995"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA2521606_01216"
                     /product="uridine kinase"
                     /protein_id="WP_001181378.1"
                     /transl_table=11
                     /translation="MQNRPIIIGVTGGSGGGKTSVSRAILSHFPDEKISMIEHDSYYKD
                     QSHLTFEERVKTNYDHPFAFDTDLMIEQIKELLAGRPVDIPTYDYTEHTRSSKTYRQEP
                     QDVFIVEGILVLEDKRLRDLMDIKIFVDTDDDVRIIRRIKRDMEERGRSLDSVINQYLG
                     VVKPMYHQFIESTKRYADIVIPEGVSNTVAIDLLTTKIAKILEEARNSK"
     gene            8474..9814
                     /gene="xseA"
                     /locus_tag="A1898_RS06000"
                     /old_locus_tag="SAMEA2521606_01217"
     CDS             8474..9814
                     /EC_number="3.1.11.6"
                     /GO_component="GO:0009318 - exodeoxyribonuclease VII
                     complex [Evidence IEA]"
                     /GO_function="GO:0008855 - exodeoxyribonuclease VII
                     activity [Evidence IEA]"
                     /GO_process="GO:0006308 - DNA catabolic process [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="xseA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012000165.1"
                     /locus_tag="A1898_RS06000"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA2521606_01217"
                     /product="exodeoxyribonuclease VII large subunit"
                     /protein_id="WP_000417489.1"
                     /transl_table=11
                     /translation="MEKYLSVTTLTKYLKMKFDKDPYLERVYLTGQVSNFRKRPTHQYF
                     SLKDDHAVIQATIWSGIYQKLGFDLEEGMKINVIGRVQVYEPSGSYSIIIEKVEPDGVG
                     ALAIQFEQLKKKLTEEGLFQERFKQALPQFSKRIGVVTSRSGAVIRDIITTVSRRFPGV
                     DILLYPTKVQGEGAAEEIARNIARANQRDDLDLLIIGRGGGSIEDLWAFNEEIVVRAIF
                     ESRLPVISSVGHETDVTLADFVADRRAATPTAAAELATPVTKLDVLAHLQNQEKRMVTA
                     VRNVLSKKQEALKKCSQSVIFRQPERLYDGYLQRLDQLQLRLKQSLRTRISDNKQLVQA
                     RTHQLVQLSPVTKIQRYQDRLGQLDKLLGSQMALVYDAKVAEVKRLSEALLMLDTSRIV
                     ARGYAIVKKEESVVDSVESLKKKDQVTLLMRDGQVELEVKDVKTKEI"
     misc_feature    complement(8514..8528)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: medium, score: 23.47"
                     /tool="antismash"
     gene            9792..10004
                     /locus_tag="A1898_RS06005"
                     /old_locus_tag="SAMEA2521606_01218"
     CDS             9792..10004
                     /EC_number="3.1.11.6"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008809086.1"
                     /locus_tag="A1898_RS06005"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA2521606_01218"
                     /product="exodeoxyribonuclease VII small subunit"
                     /protein_id="WP_000043230.1"
                     /transl_table=11
                     /translation="MSKQKKFEENLAELETIVQSLENGEIALEDAITAFQKGMVLSKEL
                     QATLDKAEKTLVKVMQEDGTESDFE"
     gene            10001..10876
                     /locus_tag="A1898_RS06010"
                     /old_locus_tag="SAMEA2521606_01219"
     CDS             10001..10876
                     /EC_number="2.5.1.-"
                     /GO_function="GO:0004659 - prenyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene-precursor: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000743807.1"
                     /locus_tag="A1898_RS06010"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA2521606_01219"
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_000743819.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 5.1e-58, bitscore:
                     188.4, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKQEKLALVESALEDFYGDQQFASSLRESVLYSIHAGGKRIRPF
                     LLLEVLEALQVTIKPAHAQVATALEMIHTGSLIHDDLPAMDDDDYRRGRLTNHKKFGEA
                     MAILAGDALFLDSYALIAQADLPSQIKVDLIANLSLASGSLGMVAGQVLDMEGEHQHLS
                     LEELQTIHANKTGKLLAYPFQAAAIIAELSPEMQVKLKTVGELIGLAFQVRDDVLDVTA
                     SFEEIGKTPQKDLQAEKSTYPALLGLEESIAFCNQTLDQANEKLEEIAQQLPFETESIV
                     SVVESLRING"
     gene            10869..11684
                     /locus_tag="A1898_RS06015"
                     /old_locus_tag="SAMEA2521606_01220"
     CDS             10869..11684
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_process="GO:0032259 - methylation [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001041085.1"
                     /locus_tag="A1898_RS06015"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA2521606_01220"
                     /product="TlyA family RNA methyltransferase"
                     /protein_id="WP_001041079.1"
                     /transl_table=11
                     /translation="MAKERVDVLAYKQGLFETREQAKRGVMAGLVVAVLNGERFDKPGE
                     KIPDDTELKLKGEKLKYVSRGGLKLEKALQVFDLSVDGATTIDIGASTGGFTDVMLQNS
                     AKLVFAVDVGTNQLAWKLRQDPRVVSMEQFNFRYAEKTDFEQEPSFASIDVSFISLSLI
                     LPALHRVLADQGQVVALVKPQFEAGREQIGKNGIIRDAKVHQNVLESVTAMAVEVGFSV
                     LGLDFSPIQGGHGNIEFLAYLKKEKSASNQILAEIKEAVERAHSQFKNE"
     gene            11677..12108
                     /locus_tag="A1898_RS06020"
                     /old_locus_tag="SAMEA2521606_01221"
     CDS             11677..12108
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001034407.1"
                     /locus_tag="A1898_RS06020"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA2521606_01221"
                     /product="arginine repressor"
                     /protein_id="WP_001034415.1"
                     /transl_table=11
                     /translation="MNKKERLEKIRRLVTDYQIGTQEEIVEHLKEAGITATQATVSRDI
                     KELGIVKIPLRDNTYVYELPKSIVKSLQLAEDNIESAELMDKMINLQVIPGNTAFVKAQ
                     LIETFADKIFSCLTDDSSILVIARSGSLAEEIFEQVKNW"
     gene            12115..13782
                     /gene="recN"
                     /locus_tag="A1898_RS06025"
                     /old_locus_tag="SAMEA2521606_01222"
     CDS             12115..13782
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0006281 - DNA repair [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /codon_start=1
                     /gene="recN"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399602.1"
                     /locus_tag="A1898_RS06025"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA2521606_01222"
                     /product="DNA repair protein RecN"
                     /protein_id="WP_000923583.1"
                     /transl_table=11
                     /translation="MLLEISIKNFAIIEAISLNFEKGMTVLTGETGAGKSIIIDAMNMM
                     LGARATTDVIRHGAPKAEIEGLFSVENSRLLQEIFDEQGLELGDEIIIRREILQNGRSI
                     SRVNGQMVNLSVLRAIGQHLVDIHGQHDHEELMRPQLHIQMLDEFGDAAFWDLKETYQT
                     SFDAYRKMRKQVLEVKKNQQEHKARIEMLEFQMAEIEAANLQAGEDLDLNQERDKLLNH
                     KNIADTLTNAYSMLDNEDFSSLANVRSAMNDMESVEEYDPEYREISSSLSETYYVLEDI
                     SKRLEAIIEDLDFDGNRLMQVENRLDLLHTITRKYGGTVDDVLLYFAKITEEYNLLTGN
                     NLSSEDMEAELKKLEVNLVNLAGQLASARHNLAQQLEAEIKQELQDLYMEKAQFQVRFS
                     KGKFSREGNEMVEFYISTNPGEDFKPLVKVASGGELSRLMLAIKSAFSRKEGKTSIVFD
                     EVDTGVSGRVAQAIAQKIHKIGQYGQVLAISHLPQVIAIADYQFFIEKISNDHSTVSTV
                     RLLTVEERVEEVAKMLAGDDVTEAALTQARELLRNREK"
     gene            13784..14512
                     /locus_tag="A1898_RS06030"
                     /old_locus_tag="SAMEA2521606_01223"
     CDS             13784..14512
                     /EC_number="3.1.-.-"
                     /GO_function="GO:0042578 - phosphoric ester hydrolase
                     activity [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000133310.1"
                     /locus_tag="A1898_RS06030"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA2521606_01223"
                     /product="metallophosphoesterase family protein"
                     /protein_id="WP_000133339.1"
                     /transl_table=11
                     /translation="MTDYYVIGDVHGKAGMLEDLLKTWDGQTQLLFLGDLIDRGEDSHR
                     VLEMVKDLVDNQGAICLSGNHEYMFLTWLDDPEESYDHYRRNGGDTTINSILGRPLDAP
                     VDGVEDAKRVAAEAADLVEFIRQMPFVVETDKYIFVHAGIDLTLDDWHETTDYKKVWLR
                     KPFHGAENHTGKTIVFGHTPVYGLLQQERGTSELWTTEDGKIGMDGGAVYGGVLHGIVF
                     TDQGMTEHHFIENDGFVAED"
     gene            14591..16414
                     /gene="lepA"
                     /locus_tag="A1898_RS06035"
                     /old_locus_tag="SAMEA2521606_01224"
     CDS             14591..16414
                     /EC_number="3.6.5.n1"
                     /GO_function="GO:0003924 - GTPase activity [Evidence IEA]"
                     /GO_function="GO:0005525 - GTP binding [Evidence IEA]"
                     /codon_start=1
                     /gene="lepA"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1190: GTP-binding protein LepA"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001047203.1"
                     /locus_tag="A1898_RS06035"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA2521606_01224"
                     /product="translation elongation factor 4"
                     /protein_id="WP_001047191.1"
                     /transl_table=11
                     /translation="MNLEELKKRQEKIRNFSIIAHIDHGKSTLADRILEKTETVSSREM
                     HAQLLDSMDLERERGITIKLNAIELNYTAKDGETYIFHLIDTPGHVDFTYEVSRSLAAC
                     EGAILVVDAAQGIEAQTLANVYLALDNDLEIMPIINKIDLPAADPERVRTEIEDVIGLD
                     ASEAVLASAKAGIGIEEILEQIVEKVPAPTGDVTAPLKALIFDSVYDAYRGVILQVRVM
                     DGVVKPGDKIQLMSNSKTFDVAEVGIFTPKAVGRDFLATGDVGYIAASIKTVQDTRVGD
                     TVTLATNPAAEPLHGYKQMNPMVFAGLYPIESNKYNDLREALEKLQLNDASLQFEPETS
                     QALGFGFRCGFLGLLHMDVIQERLEREFNIDLIMTAPSVIYKVNLTDGESMDVSNPSEF
                     PDPTKIATIEEPYVKAQIMVPQEFVGAVMELAQRKRGDFVTMDYIDDNRVNVIYQIPLA
                     EIVFDFFDKLKSSTRGYASFDYELSEYRPSKLVKMDILLNGDKVDALSFIVHKDFAYER
                     GKLIVDKLKKIIPRQQFEVPIQAAIGHKIVARTDIKALRKNVLAKCYGGDVSRKRKLLE
                     KQKAGKKRMKSIGSVEVPQEAFLSVLSMDEE"
     gene            complement(16495..16647)
                     /locus_tag="A1898_RS11240"
     CDS             complement(16495..16647)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="A1898_RS11240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_001855080.1"
                     /transl_table=11
                     /translation="MKIKEQTRKLAAGYSKHSFEVVDKTDEVSNHTYGKATMTWFEEIF
                     EEYKN"
     gene            16826..17302
                     /locus_tag="A1898_RS06045"
                     /old_locus_tag="SAMEA2521606_01225"
                     /pseudo=""
     CDS             16826..17302
                     /GO_component="GO:1902495 - transmembrane transporter
                     complex [Evidence IEA]"
                     /GO_function="GO:0016301 - kinase activity [Evidence IEA]"
                     /GO_process="GO:0008643 - carbohydrate transport [Evidence
                     IEA]"
                     /GO_process="GO:0009401 - phosphoenolpyruvate-dependent
                     sugar phosphotransferase system [Evidence IEA]"
                     /GO_process="GO:0016310 - phosphorylation [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000242196.1"
                     /locus_tag="A1898_RS06045"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA2521606_01225"
                     /product="PTS sugar transporter subunit IIA"
                     /pseudo=""
                     /transl_table=11
                     /translation="MVLDYFFDKNLVFCLEADNQE"
     gene            17340..17642
                     /locus_tag="A1898_RS06050"
                     /old_locus_tag="SAMEA2521606_01226"
     CDS             17340..17642
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000590570.1"
                     /locus_tag="A1898_RS06050"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA2521606_01226"
                     /product="PTS sugar transporter subunit IIB"
                     /protein_id="WP_000590559.1"
                     /transl_table=11
                     /translation="MIKILAACGAGVNSSHQIKSALEEELSNRGYDVHCDAVMVKDVNE
                     DLMKGYDIFTPIAATDLGFEPGIPVIEAGPILFCIPAMSVPVFDNIRLPAKQNMV"
     gene            17650..>17988
                     /locus_tag="A1898_RS06055"
     CDS             17650..>17988
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001105201.1"
                     /locus_tag="A1898_RS06055"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="IS5 family transposase"
                     /protein_id="WP_061813967.1"
                     /transl_table=11
                     /translation="MNYEASKQLTDARFKRLVGVQRTTFEEILAGLKTAYQLKHAKGGR
                     KPKLSLEDLLMATLQYVREYRTYEQIAADFGIHESNLIRRSQWVEVTLVQSGVTISRTP
                     LSSEDTVMI"
ORIGIN
        1 atcggaaact ttatcggagg aggcctcttg atgggtcttc catatgcctt cctcaataaa
       61 aacgaagata cttatgtaga ttaagaaaat gagcacgatt gagtcgtgct tttttcattt
      121 tcaaaataag gtaatagcta tttcttatat caaaatatag aaaactgata tttgtaaact
      181 ataactcaag gtgctacaat atccttaata aaatgatatg gaggtcacct tatgacttgt
      241 gattttaaat ttgaaactct acaactacat gctggtcaag ttgtgactcc agctactgag
      301 tctcgtgcag tgccgattta tcaaacaaca tcttttgttt ttgatgacac gtaggaaggt
      361 gccgatctgt ttgccttgag gaaaccaggg aacatttata ctcgtatcac caatcctaca
      421 acagctgccc ttgaaggtgg tgttgaagcg ctagcaacag catcaggtat gactgcagtg
      481 acttatacga ttttggcgct tgcccatgct ggtgaccatg tagtggctgc ttcgactatt
      541 tacggtggaa ccttcaatct tttgaaagaa ccccttcctc gttatggtat cacaacaacc
      601 tttgtcgata ttgataattt ggaggaagta gaagcagcta tcaaagacaa taccaagctt
      661 gtcttgattg aaaccttggg taactccttg attaatattc cagacctgga aaaactggca
      721 gagattgctc ataaacatca aatcccactt gtgtcagaca atacttttgc aacaccttat
      781 ttgattaacg tcttctctca tggcgttgac attgccattc actctgcgac taagtttatc
      841 ggtgggcatg gtacaactat tggaggaata attgtcgata gtggtcgttt tgactggacg
      901 gcttcaggga aattccctca atttgttgac gagggttcaa gctgccacaa tttgagctat
      961 attcgtgatg tgggtgcagc aacctttatt atagctgttc gagttcaatt gcttcgtgat
     1021 acaggtgcag ccttgtcacc attcaatgct ttcctcttgc tacaaagact tgaaactctt
     1081 tcacttcgtg tggaacgcca tgtacaaaat gctgagacaa ttgttgattt tcttgtcaac
     1141 catcctaagg tagaaaaggt aaattatcca aaacttgcag atagtcctta tcatgccttg
     1201 gctgagaaat acttgccaaa aggtgtcggt tcaatcttta ccttccacgt caaaggtgac
     1261 gaggaagaag cacgcaaggt cattgataat ttagaaatct tttctgacct tgcaaacgcg
     1321 gcagatgcta aatcgcttgt tgtccatcca gcaacaacca ctcacggtca attgtcagaa
     1381 aaagacctag aagcagcagg tgtcacacca aaccaaattc gtctgtcaat cggtcttgaa
     1441 aatgtagaag atttgattga agacttacgc ttggccttgg aaaaaattta aagtaaaaga
     1501 agataaacag tgggttttga ctcactgttt ttgattttcc ctcaggcatg atataatggt
     1561 tacagaagtc tagaaagagg aatgtaatga acgaaatcaa atgtcccaac tgtggggaag
     1621 tctttacagt aaatgaaagc cagtatgctg aacttttgtc ccaagtgaga acggcagagt
     1681 ttgataagga actacacgat aggatgaggc aggaactggc cttggctgag caaaaggcta
     1741 tgaatgagca acagactaaa ctggctcaga aggatcaaga aattgcgcaa ttgcagagtc
     1801 aaatccaaaa ctttgataca gaaaaagaat tggccaagaa agaagttgaa cagacaagcc
     1861 atcaggcctt attggctaag gacaaggaag tacaggcctt ggaaaaccag ttggcgacct
     1921 tgcgtttgga gcatgaaaat caattgcaaa agaccctttc tgacctagaa aaagaacgca
     1981 atcaggtcaa aaatcagctc ctactgcaag aaaaggaaaa tgagttgtct ttggcttctg
     2041 ttaagcaaaa ctacgaagcc cagctcaaag cagccagtga acaagtcgag ttttataaga
     2101 attttaaggc tcaacaatct acaaaagcga ttggggaaag cctagaacag tatgcagaga
     2161 gtgagtttaa caaggttcgt agtttcgcct ttccaaatgc ttactttgag aaggataaca
     2221 aggtctcttc gcgtgggtct aaaggggact ttatcttccg tgagtgtgat gaaaatggag
     2281 ttgaaatcat ttctatcatg tttgagatga aaaacgaagc ggacggaaca gagaagaagc
     2341 acaagaatgc agatttttac aaggaattgg acaaggaccg tcgggagaag aactgtgagt
     2401 atgccgtttt ggtgaccatg cttgaggctg ataatgacta ctttaacaca gggattgttg
     2461 acgtcagtca cgagtatgaa aaaatgtatg ttgttcgtcc tcaattcttt atccaattga
     2521 ttggtctctt acgtaatgcg gcgctaaatt ccctaaaata caagcaggag ttggccttgg
     2581 ttcgcgagca aaatattgac attacgcatt ttgaggaaga tttggatgcc tttaagctag
     2641 cttttgctaa gaactataat tcagcttcga ctaactttgg aaaagctatt gatgaaatcg
     2701 acaaggccat caaacgcatg gaagaggtta agaaattcct gactacatct gaaaaccaac
     2761 tccgtctagc taacaacaaa ttggaagatg tctctgttaa aaaattgacc cggaaaaatc
     2821 caacaatgaa agcgaagttc gaagcactga agggggagtg aggaaataag ttatggaaga
     2881 tgatcttaat tatgaaaatt tgatggatga tgtaaccgag gctataaaaa agtttaactt
     2941 agtaattttt attggcgcag gagtttcaat tgctcaaggt tatcctaatt ggaacaatta
     3001 tattgaacat cttattaagt attggcaagg acaagtttta tcggtaagtg gtgaaaaaag
     3061 gcttggaaga gaacatcacg tagtttttga tttaattagc aaatctagta ttagtaataa
     3121 acgtaaagtg gatcttgtaa actatgaatt aaaaaaagtt tttggtgaag attttgaaaa
     3181 gcgacgacta gattttgaaa aaggatattt taaaaatcta ttaccatatt caatagttaa
     3241 tcaaacagta gaatctttag caagtttgaa tgcaatattt attacttcta actacgacta
     3301 tgaaattgaa aatcatatta aacgtttaaa gaatgctgta gttactatta atgatctcaa
     3361 tgaattcact aagaacaaga atgggaaact acaatttggt gatgttctac atatccatgg
     3421 aacaccagat tgtgatgtaa agtattttgt aagttcatcc gcagattatt caaaaaccta
     3481 tttaaaaaat agggaaaatt ttgaaaattt agtaacatgg tttaaagaga caaaacctac
     3541 tgttttattt attggagcag gtcttgaaga agatgaaatt ttatctttac tttgtaaaga
     3601 tagtaagaac tatgccttga tgaagtcaga gaacacaggt aatcagagag ttgatgaaca
     3661 ttatagaggt gttgttgaag gattttttag ctcagaaaat catactcaga ttatttggta
     3721 cggagatgaa tttgagaaac tacctctttt tgtaaaaaaa ttagttgctg atattaatga
     3781 aaaattgggc acacatgatt tttataatca gtggaacaat cttttgaatc cttctataaa
     3841 tcaagaagag tataataaaa atctagatag tatttctaat gattttaagt atctaagctc
     3901 tgttttagat aaggttattg aaaatgataa taatcaacta gatcagctaa tgttaaatgc
     3961 tctgcttcgg agtgaaactc taacagtaat taaaaaaaat tttgtccttg tattttggaa
     4021 gtttattgtt aagaatattg aaaagttaag tgataatgag tgggatgtga tttataaaat
     4081 aatttatgaa ggctctcaaa attactttat agatgatgta ttctttgtct ataattatgc
     4141 gatagataat aaaatttcta gttttacaaa taataataag cttaatgaac tgagagaaat
     4201 tatatccaaa gatggatata tcgttaattc taactttaat aaagataaaa ctcttttggg
     4261 ttactggcta gtaagtgctt ttgaacagca aaatcgtgat ttatatataa aggaagatag
     4321 tgaagtagaa gttaacttaa attacgaatg tgttaacaaa ttaatgtcca tactaaataa
     4381 tccagaattt ttaagttata attactactc tatagagcat caattaaaag agtatgatgt
     4441 tgttaaattt ctttatgagc ttgtaaagtc caaaaaatta tttattgaag aggaaaagtt
     4501 tttagaaagt gattctgaag acttaataag tactatatta attcaaaaat tgcttgttca
     4561 attggataat gaaattaatt tggatttaga atttatcaag aggttaattg ataaaattga
     4621 tttttcaaat attcactttg gagaggaatt aaacactttt atcaaagaac atagaagtat
     4681 tattagagaa aaaaatattg aaataccaaa aaaaccttat agaaattgga tatcttcact
     4741 agaaggaggt tttgtttcac aattttcata tttaactcaa gaaaatcttg tagagtacga
     4801 tgaatctaga gtattagaga tattagtcaa cgccgaaaag gaacaaagag gttcttcatt
     4861 tttggaagaa aagacgataa atgaaacgga aaatttcttt attactgttt taaaagaatc
     4921 aaatgaaata tctaaaaaag tttctgattt attgaaaaat catatagatg acttatatcc
     4981 aaaatataag agattatatg taaaaattat cagttttcct gaaatagaag aaaatttgag
     5041 aaagattgtt agagaaaaat atttaaaaag atttaacaaa gaaagttttg attctaacga
     5101 tcggaaattc tttgaatatc atataaaaca acaaaatacg gatatagata tttttgaaaa
     5161 attacttagt atcaatgtga atgaactctc aacaccaaaa ggtgataata aacaattaga
     5221 tatacttcat tttataaata gtgaaatggg atcatatttt caatgtttaa tatcattatt
     5281 tataaatcat tcaagttata gagatgtaat tattcaaata ataaattcag taacagatac
     5341 tgattatagg gagtttgctc aaggtatttt attaaatgaa tacaatccaa acagaatcaa
     5401 tgtaacttac aacacctttt taggatttgc gtattatcat tctacaatta ctatcgaagc
     5461 tgcggatgtt ttcacagatg tagtaaggga tattctaaac aaaaaaattg aggacaatca
     5521 aattcttaat aaagtttatc tagttgcttt agagagggta gatccaacta ttgaatcatt
     5581 ttctttatca aagaataact atagtcaaat gataaacatc atttttacag gagactatga
     5641 atttagatat tctaaagaat ggttgggagc attattcaaa tttgactcaa gtgcaaatta
     5701 tttggtgaca attttttatt tattatataa tgaaaatctt aaaaaaaata gatttgcttt
     5761 gtttatagag gaattgagtg attacttaac aacttataac cagaaattat ctttacgagg
     5821 gatgaattat aaattgaatc atgaagaact taacaatttt gatttgttga aaaaaatgtt
     5881 tctgaaatta atggagaccg ataaaataga gaatgatatt ttttatttag atggcatcaa
     5941 aagtatactc ccattattat ctttagatga cagacgaaat gtattacaac atattcaaaa
     6001 acagaacaat tgtcctcctc cagagattga ggaattacaa agaattatag ttaattaaaa
     6061 tttgtaaaaa agagaataaa aggtagacga cgcctcagta aaaattggcc cggaaaaaag
     6121 cgaagttcga agcactgaag ggggagtaga aagcaaaaat gaacggtatt attaacttaa
     6181 aaaaggaagc aggaatgacc tcgcatgatg cggtttttaa actgcgtaag attttgggaa
     6241 ccaagaaaat tggtcatggt ggaaccttgg atccggatgt ggtgggtgtt ttgccgattg
     6301 cggttggcaa ggcgacacgc atggtcgagt ttatgcagga cgagggtaag atctatgagg
     6361 gggaaatcac tctgggctat tccacgacga ctgaggatgc tagtggggaa gtggtcgcag
     6421 aaacccctgt tttgtctccc ttggatgaaa agcttgttga tgaagcgatt gctagcttga
     6481 ctgggcctat tactcagatt ccccctatgt attcggcagt taaggttaat ggtcgcaagc
     6541 tctatgagta tgcgcgtgct ggtcaggaag cggagcgtcc agaacgtcag gtgatcattt
     6601 atcaatttga gcgaacaagt ccgatttctt atgatggcca acttgcccga ttcacttttc
     6661 gtgtaaaatg cagtaaaggg acttacatcc gtactttgtc agttgatttg ggtgaaaagc
     6721 ttggttatgc ggctcatatg tcccatttga ctcgtactag tgctgctggc ttacaattag
     6781 aagacgctct tgccttggag gaaattgctg aaaaagtaga ggctgggcaa ttagattttc
     6841 tccatccttt agagattggg acaggtgatc ttgtcaaagt tttcctaact ccagaagagg
     6901 ctacagaagt tcgctttggt cgttttattg agctagacca aacggacaaa gaactggctg
     6961 cctttgaaga tgataaattg ttagccattc tagaaaaacg gggcaatctc tataagccaa
     7021 ggaaggtttt tagctagatc gtttaggaat aaaaatcggg tgatagataa caattgcttg
     7081 ataaaacccc atactaatag tagaatggtt ttgggaatta taatattcca attgttgcga
     7141 gttgtaggta ctcaaataat ctattaggta ctcaaataat ctatatagaa atttagaggt
     7201 gtgaaatgaa gcaatttaaa attctttcag ataaatattt agagtccatt acaggttctg
     7261 gtgggaactt aggcccagga tttggtgtga taattccatg atgcgaaatg agtttcgaga
     7321 aagggtggag caacttcttc aacaaaaaga aataaatgaa aatagtgagt tgagtcacct
     7381 gtttcgtctt gctatacaaa atttagacag aaatgaaaaa taccaaacga tcatggccaa
     7441 tttgagtcaa gggttgtcac tttacctcat gacgcatcat taccaggcac ctaagtctgt
     7501 cattgatttt ggtttatgga ttgccaaagc tcctagccag gaaagaggga gactggcttt
     7561 cttgcagatg cttgctcaaa ccctacaggg ttttcgttaa aactgtcgaa catcagaggg
     7621 aagactctgg tgttttttgc tgatgagact ataaattttg taaaaaatgt gatagaatag
     7681 acgacggata aaataacgga ggatagcatg caaaatagac caatcattat tggagtgaca
     7741 ggtggttctg gtggtggtaa aaccagtgtt tcaagagcca ttttatcgca ttttcctgat
     7801 gaaaagattt ccatgattga gcatgattca tactacaagg atcagtctca tttgaccttt
     7861 gaagagcgtg tcaaaaccaa ctatgaccat ccttttgcct ttgatacaga cttgatgatc
     7921 gagcagatta aggaattgtt ggcagggcgt ccggtggaca tcccgaccta cgactataca
     7981 gagcatacac ggagtagcaa gacctatcgt caggagcctc aagatgtctt tatcgttgag
     8041 ggcattttgg tcttggagga caagcgtctg cgcgatttga tggatatcaa gatttttgtg
     8101 gatacggatg acgatgtgcg tattattcgt cgtatcaagc gtgatatgga ggagcgtggc
     8161 cgtagccttg atagcgttat taaccagtac ttaggtgtgg tcaaaccaat gtaccaccag
     8221 tttatcgagt caactaagcg ttatgctgat atcgtcattc ctgaaggggt tagcaatacc
     8281 gtggctatcg acctgttgac gaccaagatt gcaaagattt tggaagaagc tcgaaacagc
     8341 aaataatcac atgtggaggc cttgcctcct ttttctattt ttccctcata atggtacata
     8401 aatggagatt tttaggcata tttttggtat aataataccc atgaaagagc aagtaaatga
     8461 atagtaggtg gagatggaaa agtatttatc ggtaacaact ttgaccaagt atctgaaaat
     8521 gaaattcgat aaagacccat acttggaacg ggtctattta actggtcaag tttccaactt
     8581 tcgtaaacga cctactcacc aatatttctc cctaaaggat gaccatgcag ttattcaagc
     8641 gaccatctgg tctgggattt atcagaaatt agggtttgac ctggaagaag gaatgaagat
     8701 caatgtgatt gggcgtgtac aggtctatga accaagtggt agctactcca tcatcattga
     8761 aaaagttgag cctgatgggg ttggggcgct tgcgattcag tttgaacaac ttaagaaaaa
     8821 attgacagaa gaaggcctgt ttcaagaacg cttcaagcaa gctctgcccc aattttctaa
     8881 gagaattggg gtagtaacca gccgtagtgg agccgttatt cgagatatta tcacgaccgt
     8941 cagcaggcga ttcccaggtg ttgacatcct tctttatccg accaaggttc aaggtgaagg
     9001 ggctgcggag gaaattgcta gaaatattgc gcgtgctaat caacgggacg atttggattt
     9061 gctcattatt ggtcgtggag gtggttctat tgaggatctc tgggccttta acgaagaaat
     9121 tgtggtacga gctatttttg aatctcgttt gccagttatc tctagtgtgg ggcatgagac
     9181 ggatgtgacc ttggcagatt ttgtggcaga tcgacgcgct gcaacgccaa cagcggcggc
     9241 tgaactggca acacctgtga ccaagttgga tgtattagct catttgcaaa atcaggaaaa
     9301 acggatggta acggcagtcc gaaatgttct atctaagaaa caagaggctt tgaaaaaatg
     9361 cagtcagtct gttatcttta gacaacctga gcgcttgtat gacggttatt tgcaacgctt
     9421 ggaccaactg caactgcgtt tgaaacaaag tttgcgaact cggatttctg ataacaaaca
     9481 attagttcaa gcaagaactc atcaattagt acaattatca cctgttacca aaatccaacg
     9541 ctatcaagac cgtttaggac agttggacaa gctcttaggt agccaaatgg cgttagttta
     9601 tgacgccaag gttgctgagg tcaagcgact ttcggaagct ttgctcatgt tggatactag
     9661 ccgaatcgtg gcgcgtggtt atgctattgt caaaaaagaa gagtccgttg tagattcggt
     9721 tgagagtttg aagaaaaaag accaagtaac gcttttgatg cgagatggtc aagtagaatt
     9781 agaggttaaa gatgtcaaaa caaaagaaat ttgaggaaaa tctagcagaa ctggaaacca
     9841 ttgtccaaag tttggaaaat ggtgaaattg ctctggaaga tgcgattact gcctttcaaa
     9901 agggcatggt cttgtcaaaa gagctccaag ctacgctgga caaggctgaa aagaccttgg
     9961 tcaaggtcat gcaagaagac ggaacagaaa gtgattttga atgaaaaagc aagaaaaatt
    10021 agctcttgtc gagtcggctt tggaagattt ttatggagac cagcagtttg cctctagttt
    10081 acgggagtct gttctctatt ctattcatgc tggtggcaag cgtattcggc cttttctctt
    10141 gttagaagtt ctggaagcct tgcaggttac catcaaacct gctcacgcgc aggtagctac
    10201 tgccttggag atgattcata cagggagctt gattcacgat gaccttcctg ctatggatga
    10261 tgacgattat cgaagagggc ggttaaccaa tcacaagaaa ttcggtgaag ctatggccat
    10321 tttggctgga gatgccttat tcttagactc atatgccttg attgcgcagg cagatttgcc
    10381 aagtcagatt aaggtggact tgattgccaa cttatccctt gcttcaggta gtctgggtat
    10441 ggtggcaggg caagttttgg atatggaggg cgaacaccag cacttgtctt tggaagaact
    10501 tcagactatt catgccaata agactgggaa gttactagcc tatcccttcc aagcggcagc
    10561 tattatagct gaattgtcac ctgaaatgca ggtgaagctg aaaactgtgg gtgaattgat
    10621 tggacttgct tttcaagtca gagatgatgt actggatgtg acagctagtt ttgaggaaat
    10681 cggcaagaca cctcaaaagg atctgcaggc agaaaaatca acctatcctg ccttgttggg
    10741 cttggaagag tccattgcct tttgtaacca aaccctggat caagctaatg aaaaattaga
    10801 agaaattgcc cagcagcttc cctttgaaac agaatcgatt gtaagtgtag tagaaagttt
    10861 gagaatcaat ggctaaggaa agagtggatg tactagctta taaacaaggc ttgtttgaaa
    10921 cgagagagca ggccaagcga ggtgtgatgg ctggcctagt cgtagcagtc cttaatggag
    10981 aacggtttga caagccagga gagaaaattc cagatgacac cgaattaaaa ctcaaggggg
    11041 agaaactcaa gtatgtcagc cgtggtggtt tgaaactgga aaaggccttg caggtctttg
    11101 atttgtcggt ggatggcgcg actacgattg atatcggggc ctctactgga ggttttaccg
    11161 atgtcatgct acagaatagt gccaagttgg tctttgcagt cgatgttggt accaatcagt
    11221 tggcttggaa attacgccaa gacccacgag ttgtcagcat ggagcagttc aattttcgct
    11281 atgctgaaaa gactgatttc gagcaggagc cgagctttgc cagtattgat gtgagtttca
    11341 tttcccttag tctgattttg ccagccttgc accgtgtctt ggctgatcaa ggtcaggtgg
    11401 tagcacttgt caaacctcag tttgaggcag gacgtgagca gattgggaaa aatggaatta
    11461 ttcgagatgc taaggttcat cagaatgtcc ttgaatctgt aacagctatg gcagtagagg
    11521 taggtttttc agtccttggc ttggactttt ctcccatcca aggtggacat ggaaatattg
    11581 aatttttagc gtatttgaaa aaagaaaagt cagcaagcaa tcagattctt gctgagatta
    11641 aagaagcagt agagagggcg catagtcaat ttaaaaatga ataaaaaaga aagacttgaa
    11701 aaaattagaa gattggtgac agattatcaa atcggcacgc aagaagaaat tgtagaacat
    11761 ttgaaagaag caggtatcac tgccactcag gcgacggtat cccgagatat caaagagtta
    11821 ggtattgtca aaattccttt gagagacaac acttatgtct acgaattacc aaaatcaatc
    11881 gtaaaaagtc tgcaactggc tgaagacaat atcgaatcgg ctgaattgat ggataagatg
    11941 atcaatctcc aagttattcc aggaaatacg gcttttgtaa aagctcagtt aatcgagact
    12001 tttgcagaca agatttttag ctgtttgact gatgatagct cgattttagt cattgccaga
    12061 agtggaagtc tagcagagga aatctttgaa caagtaaaaa attggtaggt ctatatgtta
    12121 cttgaaattt cgataaaaaa ctttgccatt attgaggcta tttccctcaa ttttgaaaag
    12181 gggatgactg tcctgactgg tgaaacgggt gcagggaagt cgattatcat tgatgccatg
    12241 aatatgatgt tgggagctcg tgcgacgaca gatgttattc gtcatggtgc accaaaggca
    12301 gagattgagg ggcttttctc agttgagaat agtcgtcttt tacaggaaat ttttgatgag
    12361 caaggtttag aattaggtga tgaaattatc atccgtcggg aaatcttgca aaatggtcgt
    12421 agtatcagcc gtgtaaatgg tcagatggtt aatctgtctg ttttgcgagc tattgggcaa
    12481 catcttgtag atattcatgg tcagcatgac catgaggagt taatgcgtcc ccaactgcat
    12541 atccagatgt tggatgaatt tggtgatgcc gctttttggg acttgaaaga aacctatcaa
    12601 acgagttttg atgcctatcg gaaaatgcgc aagcaggttc tggaagtcaa gaaaaaccaa
    12661 caggaacaca aggcacgtat cgaaatgttg gaatttcaaa tggcagagat tgaggcagca
    12721 aacttgcagg ctggagaaga cttggatctc aatcaagagc gagataaact cctcaaccac
    12781 aaaaatattg cggatacact gaccaatgcc tacagtatgt tggacaatga agatttttca
    12841 agtctggcca atgttcgttc agccatgaat gacatggaaa gtgtcgaaga gtatgaccct
    12901 gaataccgtg aaatttcaag ctctctgtct gagacctact atgttttaga agacattagc
    12961 aaacgtttgg aagctatcat tgaggacctt gattttgatg gcaatcgcct gatgcaggtt
    13021 gagaatcgtt tggacctcct tcatactatt actcgtaagt atggtgggac tgttgatgat
    13081 gttttgcttt attttgccaa gattacggaa gaatacaatc tcttgacagg caataatctt
    13141 tcgtctgagg acatggaagc agagcttaag aagttggaag tcaatcttgt caatttggca
    13201 ggtcaacttg cttctgctcg tcataatttg gctcagcaac tcgaagctga gattaaacaa
    13261 gaactgcaag atctttatat ggaaaaagcc cagtttcagg ttcgttttag taagggaaaa
    13321 ttcagtcgtg agggaaatga aatggttgag ttttatattt caaccaaccc tggagaagac
    13381 tttaaaccct tggttaaggt tgcttctgga ggggaattat ctcgtctcat gttagccatt
    13441 aagtctgcct tttcacgtaa agaaggcaag actagcattg tctttgatga ggtggatacg
    13501 ggagtttcag gtcgtgttgc tcaagctatt gctcagaaaa ttcataaaat tggtcagtat
    13561 ggtcaggttt tggctatctc ccatttgcca caagtaattg cgattgcaga ttatcaattc
    13621 tttattgaga agattagtaa tgaccattca acggtttcga ctgttcgtct cttgacggtc
    13681 gaagagcgag tggaggaagt tgccaagatg ttggcaggtg atgatgtgac agaagcagcc
    13741 ctgacgcaag ccagagaatt gttgagaaac agggagaaat aagatgacag attattatgt
    13801 aattggagat gttcacggaa aagctgggat gctggaagac cttcttaaaa cctgggatgg
    13861 tcagacccag ttgctctttc taggtgattt gattgacaga ggtgaggata gtcaccgtgt
    13921 tcttgaaatg gtcaaggact tggtggacaa tcaaggggct atctgtttgt ctggaaacca
    13981 cgagtatatg tttttgactt ggctagatga cccagaagaa agttatgacc attatcgtcg
    14041 caatggtgga gatacaacca ttaactctat cctaggtcgt cccttggatg caccagttga
    14101 tggagtagaa gatgccaagc gggttgccgc tgaagcggca gacttggtcg aattcattcg
    14161 tcaaatgcca tttgtagtag agacagacaa gtatatcttt gttcacgcag gtattgattt
    14221 gaccttggac gactggcatg aaacaacaga ttataaaaaa gtatggctta gaaaaccatt
    14281 ccacggagct gaaaatcata ctggaaaaac cattgtcttc ggtcatacac cggtctatgg
    14341 tttgttacag caagaacgcg gtacatctga gctttggact acagaagatg gcaagattgg
    14401 aatggatgga ggagctgttt atggtggtgt ccttcacggg attgtcttta cagaccaagg
    14461 aatgacagaa caccacttta tcgaaaatga cggctttgtc gctgaagatt agtactccta
    14521 gcagggtatg gtcttgtcaa aatatcaaaa acaatttata ataaatagat accctgaaag
    14581 gaagagaatc atgaacttag aagaattgaa aaaacgacag gagaagatcc gtaacttctc
    14641 tattatcgcc catattgacc acggaaaatc aactctagca gaccgcattt tggaaaaaac
    14701 agagacggtt tcaagtcgtg aaatgcatgc ccagcttttg gatagcatgg atctagagcg
    14761 ggaacgtgga attactatta agttgaatgc catcgagttg aattacactg caaaagatgg
    14821 agaaacttat attttccact tgattgacac accagggcac gttgacttta cctatgaagt
    14881 ttcacgttcg ctagctgcct gtgagggtgc tattttggtg gtcgatgcgg ctcaaggaat
    14941 tgaggctcaa actcttgcca acgtttatct ggctttggat aatgatttgg aaatcatgcc
    15001 tatcattaat aaaattgacc tgccggctgc agatccggag cgcgtgcgta cagagattga
    15061 agatgtgatt ggtttggatg ccagtgaagc agttttggct tctgccaagg ctggtattgg
    15121 gattgaagaa atcctcgagc aaattgtaga aaaagtacca gcaccaacgg gtgatgtgac
    15181 ggcgccactt aaggccttga ttttcgactc tgtttacgat gcttaccgtg gggttatcct
    15241 ccaagtgcgt gtcatggacg gagtggtcaa acctggtgat aagattcagc ttatgagcaa
    15301 tagtaagacc tttgatgtgg ccgaagtcgg tatttttaca ccaaaagcgg ttggtcgtga
    15361 tttccttgcg actggtgatg ttggttacat tgcggcgtct atcaagacgg ttcaggatac
    15421 tcgtgtgggt gataccgtta ccttggcaac caatcctgcg gcagaaccat tacatggtta
    15481 taagcagatg aatcctatgg tctttgcggg tctctaccca atcgaatcaa acaagtacaa
    15541 tgacctgcgt gaagcgcttg aaaaattgca actgaatgat gctagtcttc agtttgaacc
    15601 agaaacatct caggcacttg gatttggttt ccgttgtgga tttcttggac ttctccatat
    15661 ggatgttatc caggaacgtt tagagcgtga gttcaatatt gacctcatca tgacagctcc
    15721 gtctgttatt tacaaagtta atttgaccga cggtgagtct atggatgtgt ctaacccatc
    15781 tgagtttcca gacccaacta agattgcgac cattgaagag ccttatgtca aggcgcaaat
    15841 catggtacca caggagttcg tcggagcagt aatggagcta gctcagcgta agcgtgggga
    15901 ctttgtgact atggactata ttgatgataa ccgtgtcaat gttatctatc aaattcctct
    15961 tgctgaaatt gtctttgact tctttgataa acttaagtct tcaacacgtg gttatgcaag
    16021 ctttgactac gaattgtcag aatatcgccc atctaagctg gtgaaaatgg atatccttct
    16081 caatggagat aaggtggatg ctctcagctt tatcgttcac aaggactttg cctacgaacg
    16141 tgggaaactc atcgttgata aactcaagaa aatcatccct cgccaacaat ttgaagttcc
    16201 aatccaagcg gctattggac acaagattgt cgctcgtact gatatcaagg cccttcgtaa
    16261 gaacgtactt gctaaatgtt atggtggtga cgtttctcgt aagcgtaaac tccttgaaaa
    16321 acaaaaagct ggtaagaaac gcatgaaatc catcggatca gttgaagttc cgcaagaagc
    16381 cttcctcagc gtcttgagta tggatgaaga ataagttatc agaaatgcct ttccttgttc
    16441 acaggaaatt tatataagaa tcaatagtaa agcaggctta gatggtctgc ttttttagtt
    16501 tttatactct tcgaaaatct cttcaaacca cgtcatcgtc gccttaccgt atgtatggtt
    16561 actgacttcg tcagtcttat ctacaacctc aaaactgtgt tttgagtaac ctgcggctag
    16621 cttcctagtt tgctctttga ttttcattga gtattagaac agaaaaatgc ttggagtatt
    16681 tgtttgtgtg tttattttta tataacaaac tataaacaaa acaaaaatat aaaaaagaga
    16741 caaaaaagaa cagaaagtaa ttaacaacga tttcatatag tgttatactt atagcataaa
    16801 gttaatggaa agaagggaaa accttatggt attagattat ttctttgaca aaaaccttgt
    16861 gttttgctta gaagcggata atcaagaata actctttgat caggtagcaa gcttgttgga
    16921 ggaacgagaa attgtcactc caacttatcg tgaagccttg atcacgcgtg aaaagtcatt
    16981 tccaactggt ttagatatgg aatttctagg aaaggacttg ccaaatgtag cgattcctca
    17041 cacagatatt gttcataatt tggctgaaaa agttgtggtc gttcgattag agaaaccggt
    17101 gactttccat aatatgattg cgccagataa ggaagtagaa gtatccttgc tcttctttat
    17161 cattaataat tcaagttcaa gtcaaacgaa cattcttgct cagttaatgg acttcttcac
    17221 aggaaatggt catcttgaag acctatcaaa aatttccgaa ccagaaaaac tttatgctta
    17281 tatagatgaa gcaatcgctt aatcttgtct attaaaaaat aaaatcggag gaagtctata
    17341 tgattaaaat tcttgctgcc tgcggtgcag gtgttaactc aagtcaccaa attaaaagtg
    17401 ctctagaaga agaactttca aaccgtggtt atgatgttca ctgtgatgca gtcatggtga
    17461 aagatgtaaa cgaagacctt atgaaaggtt acgatatctt tacaccaatc gctgcaacag
    17521 accttggttt tgaaccaggt atcccagtta tcgaagctgg gccaatctta ttctgtatcc
    17581 cagcaatgag cgttccagta tttgacaata ttagacttcc tgcgaaacaa aatatggtat
    17641 agtagttcca tgaattatga agcaagtaaa caactaactg atgcacgatt taagcgtctt
    17701 gttggtgttc agcgcacgac ttttgaagag atattagctg gattaaaaac agcttatcaa
    17761 cttaaacacg caaaaggtgg acgaaaacct aaattaagcc tagaagacct tcttatggcc
    17821 actcttcaat atgtgcgaga atatcgaact tatgaacaaa ttgcggctga ttttggtatt
    17881 cacgaaagca acttaatccg tcggagccaa tgggttgaag taactcttgt tcaaagtggt
    17941 gttacgattt caagaactcc tctcagttct gaggacacgg taatgatt
//
