LOCUS       NZ_FIXU01000014        20876 bp    DNA     linear   CON 15-DEC-2024
DEFINITION  Streptococcus pneumoniae strain B18210a, whole genome shotgun
            sequence.
ACCESSION   NZ_FIXU01000014
VERSION     NZ_FIXU01000014.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1
  CONSRTM   Pathogen Informatics
  TITLE     Direct Submission
  JOURNAL   Submitted (09-FEB-2016) SC, Wellcome Trust Sanger Institute, CB10
            1SA, United Kingdom
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_900052895.1-RS_2024_12_13
            Annotation Date                   :: 12/13/2024 02:58:16
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.9
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 2,298
            CDSs (total)                      :: 2,246
            Genes (coding)                    :: 2,088
            CDSs (with protein)               :: 2,088
            Genes (RNA)                       :: 52
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1, 1 (5S, 16S, 23S)
            tRNAs                             :: 46
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 158
            CDSs (without protein)            :: 158
            Pseudo Genes (ambiguous residues) :: 0 of 158
            Pseudo Genes (frameshifted)       :: 62 of 158
            Pseudo Genes (incomplete)         :: 91 of 158
            Pseudo Genes (internal stop)      :: 44 of 158
            Pseudo Genes (multiple problems)  :: 32 of 158
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 13:33:22
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 16557
            Orig. end                         :: 37433
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            FIXU01000014.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..20876
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene-precursor"
                     /region_number="1"
                     /rules="(PT_FPPS_like and not PT_HPP)"
                     /tool="antismash"
     cand_cluster    1..20876
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_FPPS_like and not PT_HPP)"
                     /kind="single"
                     /product="terpene-precursor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..20876
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:10876](-)"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..10876)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
     misc_feature    87..100
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: medium, score: 21.2"
                     /tool="antismash"
     gene            complement(734..1249)
                     /gene="lacB"
                     /locus_tag="A1M11_RS07385"
                     /old_locus_tag="ERS050419_01444"
     CDS             complement(734..1249)
                     /codon_start=1
                     /gene="lacB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002994294.1"
                     /locus_tag="A1M11_RS07385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS050419_01444"
                     /product="galactose-6-phosphate isomerase subunit LacB"
                     /protein_id="WP_001216918.1"
                     /transl_table=11
                     /translation="MRIAIGCDHIVTDEKMAVSEFLKSKGYEVIDFGTYDHTRTHYPIF
                     GKKVGEAVTSGQADLGVCICGTGVGINNAVNKVPGVRSALVRDMTTALYAKEQLNANVI
                     GFGGKITGELLMCDIIEAFIHAEYKPTEENKKLIAKIEHVESHNAQQTDANFFTEFLEK
                     WDRGEYHD"
     misc_feature    1215..1230
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: medium,
                     score: 17.68"
                     /tool="antismash"
     gene            complement(1280..1705)
                     /gene="lacA"
                     /locus_tag="A1M11_RS07390"
                     /old_locus_tag="ERS050419_01445"
     CDS             complement(1280..1705)
                     /EC_number="5.3.1.26"
                     /GO_function="GO:0050044 - galactose-6-phosphate isomerase
                     activity [Evidence IEA]"
                     /GO_process="GO:0019512 - lactose catabolic process via
                     tagatose-6-phosphate [Evidence IEA]"
                     /codon_start=1
                     /gene="lacA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398701.1"
                     /locus_tag="A1M11_RS07390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS050419_01445"
                     /product="galactose-6-phosphate isomerase subunit LacA"
                     /protein_id="WP_000029272.1"
                     /transl_table=11
                     /translation="MSIVIGADAAGLRLKEVVKDFLEKENFHLVDVTAEGQDFVDVTLA
                     VAAEVNKEEQNLGIVIDAYGAGPFMVATKIKGMVAAEVSDERSAYMTRGHNNSRMITMG
                     AQLVGDELAKNIAKGFVNGKYDGGRHQIRVDMLNKMG"
     misc_feature    complement(1858..1871)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: medium, score: 22.35"
                     /tool="antismash"
     gene            complement(1863..>2360)
                     /locus_tag="A1M11_RS07395"
                     /old_locus_tag="ERS050419_01446"
                     /pseudo=""
     CDS             complement(1863..>2360)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000234238.1"
                     /locus_tag="A1M11_RS07395"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="ERS050419_01446"
                     /product="aldose 1-epimerase family protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="NKETSKVMPYFIGGHPGFNCPLLDDEVYEDYYLESEKEETCSVPR
                     PFPETGMLDFQDRSPWLERQKEIDLSYDLFSKDAVTLDELQSRTIALRSLKHDKGLKVH
                     FAEFPNLIIWSTLNKGPFITFEPWSGLSTFLEEGDHLEDKKNVCLLEANQVEELGFEIE
                     VL"
     gene            complement(2376..3180)
                     /locus_tag="A1M11_RS12220"
     CDS             complement(join(2376..2810,2812..3180))
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001105201.1"
                     /locus_tag="A1M11_RS12220"
                     /note="programmed frameshift; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /product="IS5 family transposase"
                     /protein_id="WP_150860333.1"
                     /ribosomal_slippage=""
                     /transl_table=11
                     /translation="MNDEASKQLTDARFKRLVGVQRTTFEEMLAGLKTAYQLKHAKGGR
                     KPKLSLEDLLMATLQYVREYRTYEEIAADFGIHESNLIRWSQWVEVTLVQSGFTISRTS
                     LSSEDTVMIDATEVKINRPKKELANYSGKKKCHAMKAQAIVTSQGRIVSLDITVNYCHD
                     MKLFKMSRRNIGQAGKILADSGYQGLMKIYPQAQTPRKFSKLKPLTAEDKACNHVLSKE
                     RSKVENIFAKVKTLKMFSTTYRNHRKRFGLRMNLSAGIINHELGF"
     gene            complement(3188..3490)
                     /locus_tag="A1M11_RS07410"
                     /old_locus_tag="ERS050419_01449"
     CDS             complement(3188..3490)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000590570.1"
                     /locus_tag="A1M11_RS07410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS050419_01449"
                     /product="PTS sugar transporter subunit IIB"
                     /protein_id="WP_000590559.1"
                     /transl_table=11
                     /translation="MIKILAACGAGVNSSHQIKSALEEELSNRGYDVHCDAVMVKDVNE
                     DLMKGYDIFTPIAATDLGFEPGIPVIEAGPILFCIPAMSVPVFDNIRLPAKQNMV"
     gene            complement(3528..4004)
                     /locus_tag="A1M11_RS07415"
                     /old_locus_tag="ERS050419_01450"
                     /pseudo=""
     CDS             complement(3528..4004)
                     /GO_component="GO:1902495 - transmembrane transporter
                     complex [Evidence IEA]"
                     /GO_function="GO:0016301 - kinase activity [Evidence IEA]"
                     /GO_process="GO:0008643 - carbohydrate transport [Evidence
                     IEA]"
                     /GO_process="GO:0009401 - phosphoenolpyruvate-dependent
                     sugar phosphotransferase system [Evidence IEA]"
                     /GO_process="GO:0016310 - phosphorylation [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000242196.1"
                     /locus_tag="A1M11_RS07415"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="ERS050419_01450"
                     /product="PTS sugar transporter subunit IIA"
                     /pseudo=""
                     /transl_table=11
                     /translation="MVLDYFFDKNLVFCLEADNQE"
     gene            4185..4382
                     /locus_tag="A1M11_RS13510"
                     /old_locus_tag="ERS050419_01451"
     CDS             4185..4382
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="A1M11_RS13510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="ERS050419_01451"
                     /product="hypothetical protein"
                     /protein_id="WP_061747163.1"
                     /transl_table=11
                     /translation="MKIKEQTRKLAVGYSKHSFEVVDETDEVSSKHDFEVVDETDEVSN
                     HTYGKATLTWFEEIFEEYKN"
     gene            complement(4463..6286)
                     /gene="lepA"
                     /locus_tag="A1M11_RS07425"
                     /old_locus_tag="ERS050419_01452"
     CDS             complement(4463..6286)
                     /EC_number="3.6.5.n1"
                     /GO_function="GO:0003924 - GTPase activity [Evidence IEA]"
                     /GO_function="GO:0005525 - GTP binding [Evidence IEA]"
                     /codon_start=1
                     /gene="lepA"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1190: GTP-binding protein LepA"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001047203.1"
                     /locus_tag="A1M11_RS07425"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS050419_01452"
                     /product="translation elongation factor 4"
                     /protein_id="WP_001047204.1"
                     /transl_table=11
                     /translation="MNLEELKKRQEKIRNFSIIAHIDHGKSTLADRILEKTETVSSREM
                     QAQLLDSMDLERERGITIKLNAIELNYTAKDGETYIFHLIDTPGHVDFTYEVSRSLAAC
                     EGAILVVDAAQGIEAQTLANVYLALDNDLEIMPIINKIDLPAADPERVRTEIEDVIGLD
                     ASEAVLASAKAGIGIEEILEQIVEKVPAPTGDVTAPLKALIFDSVYDAYRGVILQVRVM
                     DGVVKPGDKIQLMSNSKTFDVAEVGIFTPKAVGRDFLATGDVGYIAASIKTVQDTRVGD
                     TVTLATNPAAEPLHGYKQMNPMVFAGLYPIESNKYNDLREALEKLQLNDASLQFEPETS
                     QALGFGFRCGFLGLLHMDVIQERLEREFNIDLIMTAPSVIYKVNLTDGESMDVSNPSEF
                     PDPTKIATIEEPYVKAQIMVPQEFVGAVMELAQRKRGDFVTMDYIDDNRVNVIYQIPLA
                     EIVFDFFDKLKSSTRGYASFDYELSEYRPSKLVKMDILLNGDKVDALSFIVHKDFAYER
                     GKLIVDKLKKIIPRQQFEVPIQAAIGHKIVARTDIKALRKNVLAKCYGGDVSRKRKLLE
                     KQKAGKKRMKSIGSVEVPQEAFLSVLSMDEE"
     gene            complement(6365..7093)
                     /locus_tag="A1M11_RS07430"
                     /old_locus_tag="ERS050419_01453"
     CDS             complement(6365..7093)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000133310.1"
                     /locus_tag="A1M11_RS07430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS050419_01453"
                     /product="metallophosphoesterase"
                     /protein_id="WP_061747164.1"
                     /transl_table=11
                     /translation="MTDYYVIGDVHGKAGMLEDLLKTWDGQTQLLFLGDLIDRGEDSHR
                     VLEMVKDFVDNQGAICLSGNHEYMFLTWLDDPEESYDHYRRNGGDTTINSILGRPLDAP
                     VDGVEDAKRVAAEAADLVEFIRQMPFVVETDKYIFVHAGIDLTLDDWHETTDYKKVWLR
                     KPFHGAENHTGKTIVFGHTPVYGLLQQERGTSELWTTEDGKIGMDGGAVYGGVLHGIVF
                     TDQGMTEHHFIENDGFVAED"
     gene            complement(7095..8762)
                     /gene="recN"
                     /locus_tag="A1M11_RS07435"
                     /old_locus_tag="ERS050419_01454"
     CDS             complement(7095..8762)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0006281 - DNA repair [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /codon_start=1
                     /gene="recN"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399602.1"
                     /locus_tag="A1M11_RS07435"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS050419_01454"
                     /product="DNA repair protein RecN"
                     /protein_id="WP_000923596.1"
                     /transl_table=11
                     /translation="MLLEISIKNFAIIEAISLNFEKGMTVLTGETGAGKSIIIDAMNMM
                     LGARATTDVIRHGAPKAEIEGLFSVENSRLLQEIFDEQGLELGDEIIIRREILQNGRSI
                     SRVNGQMVNLSVLRTIGQHLVDIHGQHDHEELMRPQLHIQMLDEFGDAAFWDLKETYQT
                     SFDAYRKMRKQVLEVKKNQQEHKARIEMLEFQMAEIEAANLQAGEDLDLNQERDKLLNH
                     KNIADTLTNAYSMLDNEDFSSLANVRSAMNDMESVEEYDPEYREISSSLSETYYVLEDI
                     SKRLEAIIEDLDFDGNRLMQVENRLDLLHTITRKYGGTVDDVLLYFAKITEEYNLLTGN
                     NLSSEDMEAELKKLEVNLVNLAGQLASARHNLAQQLEAEIKQELQDLYMEKAQFQVRFS
                     KGKFSREGNKMVEFYISTNPGEDFKPLVKVASGGELSRLMLAIKSAFSRKEGKTSIVFD
                     EVDTGVSGRVAQAIAQKIHKIGQHGQVLAISHLPQVIAIADYQFFIEKISNDHSTVSTV
                     RLLTVEERVEEVAKMLAGDDVTEAALTQARELLRNREK"
     gene            complement(8769..9200)
                     /locus_tag="A1M11_RS07440"
                     /old_locus_tag="ERS050419_01455"
     CDS             complement(8769..9200)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001034407.1"
                     /locus_tag="A1M11_RS07440"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS050419_01455"
                     /product="arginine repressor"
                     /protein_id="WP_001034415.1"
                     /transl_table=11
                     /translation="MNKKERLEKIRRLVTDYQIGTQEEIVEHLKEAGITATQATVSRDI
                     KELGIVKIPLRDNTYVYELPKSIVKSLQLAEDNIESAELMDKMINLQVIPGNTAFVKAQ
                     LIETFADKIFSCLTDDSSILVIARSGSLAEEIFEQVKNW"
     gene            complement(9193..10008)
                     /locus_tag="A1M11_RS07445"
                     /old_locus_tag="ERS050419_01456"
     CDS             complement(9193..10008)
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_process="GO:0032259 - methylation [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001041085.1"
                     /locus_tag="A1M11_RS07445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS050419_01456"
                     /product="TlyA family RNA methyltransferase"
                     /protein_id="WP_001041072.1"
                     /transl_table=11
                     /translation="MAKERVDVLAYKQGLFETREQAKRGVMAGLVVAVLNGERFDKPGE
                     KIPDDTELKLKGEKLKYVSRGGLKLEKALQVFDLSVDGATTIDIGASTGGFTDVMLQNS
                     AKLVFAVDVGTNQLAWKLRQDPRVVSMEQFNFRYAEKTDFEQEPSFASIDVSFISLSLI
                     LPALHRVLADQGQVVALVKPQFEAGREQIGKNGIIRDAKIHQNVLESVTAMAVEAGFSV
                     LGLDFSPIQGGHGNIEFLAYLKKEKSASNQIFAEIKEAVERAHSQFKNE"
     gene            complement(10001..10876)
                     /locus_tag="A1M11_RS07450"
                     /old_locus_tag="ERS050419_01457"
     CDS             complement(10001..10876)
                     /EC_number="2.5.1.-"
                     /GO_function="GO:0004659 - prenyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene-precursor: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000743807.1"
                     /locus_tag="A1M11_RS07450"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS050419_01457"
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_000743808.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 1.9e-57, bitscore:
                     186.4, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKQEKLALVESALEDFYGDQQFASSLRESVLYSIHAGGKRIRPF
                     LLLEVLEALQVAIKPAHAQVATALEMIHTGSLIHDDLPAMDDDDYRRGRLTNHKKFGEA
                     MAILAGDALFLDPYALIAQADLPSQIKVDLIANLSLASGSLGMVAGQVLDMEGEHQHLS
                     LEELQTIHANKTGKLLAYPFQAAAIIAELSPEMQVKLKTVGELIGLAFQVRDDVLDVTA
                     SFEEIGKTPQKDLQAEKSTYPALLGLEESIAFCNQTLDQANEKLEEIAQQLPFETESIV
                     SVVESLRING"
     gene            complement(10873..11085)
                     /locus_tag="A1M11_RS07455"
                     /old_locus_tag="ERS050419_01458"
     CDS             complement(10873..11085)
                     /EC_number="3.1.11.6"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008809086.1"
                     /locus_tag="A1M11_RS07455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS050419_01458"
                     /product="exodeoxyribonuclease VII small subunit"
                     /protein_id="WP_000043230.1"
                     /transl_table=11
                     /translation="MSKQKKFEENLAELETIVQSLENGEIALEDAITAFQKGMVLSKEL
                     QATLDKAEKTLVKVMQEDGTESDFE"
     gene            complement(11063..12403)
                     /gene="xseA"
                     /locus_tag="A1M11_RS07460"
                     /old_locus_tag="ERS050419_01459"
     CDS             complement(11063..12403)
                     /EC_number="3.1.11.6"
                     /GO_component="GO:0009318 - exodeoxyribonuclease VII
                     complex [Evidence IEA]"
                     /GO_function="GO:0008855 - exodeoxyribonuclease VII
                     activity [Evidence IEA]"
                     /GO_process="GO:0006308 - DNA catabolic process [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="xseA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012000165.1"
                     /locus_tag="A1M11_RS07460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS050419_01459"
                     /product="exodeoxyribonuclease VII large subunit"
                     /protein_id="WP_000417462.1"
                     /transl_table=11
                     /translation="MEKYLSVTTLTKYLKMKFDKDPYLERVYLTGQVSNFRKRPTHQYF
                     SLKDDHAVIQATIWSGIYQKLGFDLEEGMKINVIGRVQVYEPSGSYSIIIEKAEPDGVG
                     ALAIQFEQLKKKLTEEGLFQERFKQALPQFSKRIGVVTSRSGAVIRDIITTVSRRFPGV
                     DILLYPTKVQGEGAAEEIARNIARANQRDDLDLLIIGRGGGSIEDLWAFNEEIVVRAIF
                     ESRLPVISSVGHETDVTLADFVADRRAATPTAAAELATPVTKLDVLAHLQNQEKRMATA
                     VRNVLSKKQEALKKCSQSVIFRQPERLYDGYLQRLDQLQLRLKQSLRTRISDNKQLVQA
                     RTHQLVQLSPVTKIQRYQDRLGQLDKLLGSQMALVYDAKVAEAKRLSEALLMLDTSRIV
                     ARGYAIVKKEESVVDSVESLKKKDQVTLLMRDGQVELEVKDVKTKEI"
     gene            complement(12531..13169)
                     /gene="udk"
                     /locus_tag="A1M11_RS07465"
                     /old_locus_tag="ERS050419_01460"
     CDS             complement(12531..13169)
                     /EC_number="2.7.1.48"
                     /GO_function="GO:0004849 - uridine kinase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="udk"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001181378.1"
                     /locus_tag="A1M11_RS07465"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS050419_01460"
                     /product="uridine kinase"
                     /protein_id="WP_061454824.1"
                     /transl_table=11
                     /translation="MQNRPIIIGVTGGSGGGKTSVSRAILSHFPDEKISMIEHDSYYKD
                     QSHLTFEERVKTNYDHPFAFDTDLMIEQIKELLAGRPVDIPTYDYTEHTRSSKTYRQEP
                     QDVFIVEGILVLEDKRLRDLMDIKIFVDTDDDVRIIRRIKRDMEERGRSLDSVINQYLG
                     VVKPMYHQFIESTKRYADIVIPEGVSNTVAIDLLTTKIAKILEEARISK"
     misc_feature    13209..13223
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence:
                     medium, score: 22.39"
                     /tool="antismash"
     gene            complement(13277..13579)
                     /locus_tag="A1M11_RS07470"
                     /old_locus_tag="ERS050419_01461"
     CDS             complement(13277..13579)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000985087.1"
                     /locus_tag="A1M11_RS07470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS050419_01461"
                     /product="bacteriocin immunity protein"
                     /protein_id="WP_000985089.1"
                     /transl_table=11
                     /translation="MMRNEFRERVEQLLQQKEINENSELSHLFRLAIQNLDRNEKYQSV
                     MANLSQGLSLYLMTHHYQAPKSVIDFGLWIAKAPSQERGRLAFLQMLAQTLQGFR"
     gene            complement(13832..14710)
                     /gene="truB"
                     /locus_tag="A1M11_RS07475"
                     /old_locus_tag="ERS050419_01463"
     CDS             complement(13832..14710)
                     /EC_number="5.4.99.25"
                     /GO_function="GO:0003723 - RNA binding [Evidence IEA]"
                     /GO_function="GO:0009982 - pseudouridine synthase activity
                     [Evidence IEA]"
                     /GO_process="GO:0001522 - pseudouridine synthesis [Evidence
                     IEA]"
                     /GO_process="GO:0009451 - RNA modification [Evidence IEA]"
                     /codon_start=1
                     /gene="truB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006145474.1"
                     /locus_tag="A1M11_RS07475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS050419_01463"
                     /product="tRNA pseudouridine(55) synthase TruB"
                     /protein_id="WP_061747165.1"
                     /transl_table=11
                     /translation="MNGIINLKKEAGMTSHDAVFKLRKILGTKKIGHGGTLDPDVVGVL
                     PIAVGKATRMVEFMQDEGKIYEGEITLGYSTTTEDASGEVIAETPVLSPLDEKLVDEAI
                     ASLTGPITQIPPMYSAVKVNGRKLYEYARAGQEVERPERQVTIYQFERTSPISYDGQLA
                     RFTFRVKCSKGTYIRTLSVDLGEKLGYAAHMSHLTRTSAAGLQLEDALTLEEIAEKVEA
                     GQLDFLHPLEIGTGDLVKVFLTPEEATEVRFGRFIELDQTDKELAAFEDDKLLAILEKW
                     GNLYKPRKVFS"
     gene            complement(14720..15994)
                     /locus_tag="A1M11_RS07480"
                     /old_locus_tag="ERS050419_01464"
     CDS             complement(14720..15994)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001002592.1"
                     /locus_tag="A1M11_RS07480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS050419_01464"
                     /product="DUF2130 domain-containing protein"
                     /protein_id="WP_001002635.1"
                     /transl_table=11
                     /translation="MNEIKCPNCGEVFTVNESQYAELLSQVRTAEFDKELHDRMRQELA
                     LAEQKAMNEQQTKLAQKDQEIAQLQSQIQNFDTEKELAKKEVEQTSHQALLAKDKEVQA
                     LENQLATLRLEHENQLQKTLSDLEKERNQVKNQLLLQEKENELSLASVKQNYEAQLKAA
                     SEQVEFYKNFKAQQSTKAIGESLEQYAESEFNKVRSFAFPNAYFEKDNKVSSRGSKGDF
                     IFRECDENGVEIISIMFEMKNEADGTEKKHKNADFYKELDKDRREKNCEYAVLVTMLEA
                     DNDYFNTGIVDVSHEYEKMYVVRPQFFIQLIGLLRNAALNSLKYKQELALVREQNIDIT
                     HFEEDLDAFKLAFAKNYNSASTNFGKAIDEIDKAIKRMEEVKKFLTTSENQLRLANNKL
                     EDVSVKKLTRKNPTMKAKFEALKGE"
     gene            complement(16090..17349)
                     /locus_tag="A1M11_RS07485"
                     /old_locus_tag="ERS050419_01465"
                     /pseudo=""
     CDS             complement(16090..17349)
                     /GO_function="GO:0016765 - transferase activity,
                     transferring alkyl or aryl (other than methyl) groups
                     [Evidence IEA]"
                     /GO_function="GO:0030170 - pyridoxal phosphate binding
                     [Evidence IEA]"
                     /GO_process="GO:0019346 - transsulfuration [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018365067.1"
                     /locus_tag="A1M11_RS07485"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="ERS050419_01465"
                     /product="O-acetylhomoserine
                     aminocarboxypropyltransferase/cysteine synthase family
                     protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MTCDFKFETLQLHAGQVVAPATKSRAVPIYQTTFFVFDDT"
     gene            complement(17497..18294)
                     /locus_tag="A1M11_RS07490"
                     /old_locus_tag="ERS050419_01467"
     CDS             complement(17497..18294)
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_function="GO:0015499 - formate transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_process="GO:0015724 - formate transport [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000254803.1"
                     /locus_tag="A1M11_RS07490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS050419_01467"
                     /product="formate/nitrite transporter family protein"
                     /protein_id="WP_000254794.1"
                     /transl_table=11
                     /translation="MVSSEFISKIEFACNKKESLYSQSKFKYAIRSMFAGAFLTFSTAA
                     GAVGADLINKIAPGSGRFLFPFVFAWGLAYIVFLNAELVTSNMMFLTAGSFLKKISWRK
                     TAEILLYCTLFNLIGALIAGWGFAHSAAYANLIHDSFISGVVEMKLGRSNELVLLEAIL
                     ANIFVNIAILSFILVKDGGAKLWLVLSAIYMFVFLTNEHIAANFASFAIVKFSVAADSI
                     ANFGVGNMLRHWGVTFIGNFIGGGLLMGLPYAFLNKNEDTYVD"
     misc_feature    complement(18447..18461)
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 19.19"
                     /tool="antismash"
     gene            complement(18538..19281)
                     /gene="srtA"
                     /locus_tag="A1M11_RS07495"
                     /old_locus_tag="ERS050419_01468"
     CDS             complement(18538..19281)
                     /codon_start=1
                     /gene="srtA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000078846.1"
                     /locus_tag="A1M11_RS07495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS050419_01468"
                     /product="sortase SrtA"
                     /protein_id="WP_000078846.1"
                     /transl_table=11
                     /translation="MSQKNNKKKNKRKNLLTNILAGFLILLSLALIFNTQIRNIFIVWN
                     TNKYQVSQVSKEKLEENQDTEGNFDFDSVKAISSEAVLTSQWDAQKLPVIGGIAIPELE
                     MNLPIFKGLDNVNLFYGAGTMKREQVMGEGNYSLASHHIFGVDNANKMLFSPLDNAKNG
                     MKIYLTDKNKVYTYEIREVKRVTPDRVDEVDDRDGVNEITLVTCEDLAATERIIVKGDL
                     KETKDYSQTSDEILTAFNQPYKQFY"
ORIGIN
        1 aggaatatct accttgtaga aagtgtcacc atgtttggca aaagtaccgt tggcaccaag
       61 tgaaacgata atccattcaa tccctgcaaa caaaggttct tgaagtactt cttttaattc
      121 atccaaatcc tcagaaactt ctcttccaag aagctgagac aattcttcat tatttggttt
      181 gatgactgtt ggtttatggg gtgattcaag aacagcctga agtgctgcac ctgagcagtc
      241 caagactaca ggcttgccag cttgattagc aagttctacc aagctcgcat agtaatcaac
      301 tggaaggcca gctggcagac tacctgagat ggctactact tcaactgact ccaagagttt
      361 tttgaaatgt tccaaaaact cttgaccttc ctgttccaat acttcaggac ctttttcaag
      421 aacttctgtt tggttgtctc cgtggagaat agcgatacag ttacgagttt ctccctgaat
      481 tgagaagaaa tctttcttta cttgattatc gatatgttca actaaaaact caccaagttt
      541 gccaccaact aaaccagtag caagaacaga atcaccaaat tctgaaagta ctcgagtgac
      601 gttcagtccc ttaccaccag ccgttttggt tacatccacc acacgattga cagtatcaat
      661 cttcaactca tccaagggat aggaaatatc gatggatggg ttcattgtga ctgttaaaat
      721 cataggtcac ctcttagtcg tggtattctc cgcgatccca tttttcaagg aattcagtga
      781 agaagtttgc gtctgtttgt tgagcattgt gactttcaac atgttcaatt ttcgcaatta
      841 attttttgtt ttcttcagtt ggtttgtatt cagcatggat gaaagcttcg atgatatcac
      901 acataagcaa ttcaccagta attttaccac caaaaccaat aacgttagcg ttcaattgtt
      961 ctttagcata aagggctgtt gtcatatcac gaaccaaggc agagcgaaca cctggaactt
     1021 tattcacagc gttgttgata ccaacaccag taccacagat acataccccg agatcagctt
     1081 gaccactagt tactgcttcc cctacttttt taccaaagat tgggtagtga gtacgtgtat
     1141 ggtcataggt accaaagtca atgacttcat atccttttga tttcaaaaat tctgaaaccg
     1201 ccattttttc atctgttacg atgtggtcac atccaattgc aattctcatt tttaacttac
     1261 ctttcttact gtaatctaat taacccattt tgttcaacat gtcaacccgg atttggtgac
     1321 gaccaccgtc gtatttacca ttaacaaatc ctttagcgat gtttttagcc aattcatcac
     1381 caacaagttg tgcccccata gtgatcatac gtgagttgtt gtggccacga gtcatataag
     1441 ctgaacgttc gtcagatact tctgcagcaa ccattccttt gatcttagtt gcaaccataa
     1501 atggaccagc tccataagca tcaatcacga taccaaggtt ttgttcttct ttgtttactt
     1561 ctgcagcaac agcgagagtc acatcaacaa agtcttgacc ttcagctgta acatccacaa
     1621 ggtggaagtt ttctttttct aagaagtctt tcacaacttc tttcaatctc aaacctgcag
     1681 catctgcacc gataacaata gacatattgt atactccttt ttattttttc tatgctggat
     1741 tccagcaatg tattgactgt ctttaaaaaa cagtcaatta gtcctcacaa acataatata
     1801 ctactattgt ttgaagaagt caacagcttt tgtttgtttt tgttatttat tttttacttt
     1861 ttttataaaa cttctatctc aaaccctaat tcttcaacct gattggcttc taagagacaa
     1921 acattcttct tatcttctaa atgatctcct tcttcaagga atgttgacaa gccagaccat
     1981 ggttcaaagg taatgaaagg tcccttgttc aaagttgacc agatgatgag gtttggaaat
     2041 tctgcaaaat gcactttcaa tcccttatca tgtttaagag aacgaagggc aattgttcga
     2101 gattgcaatt catccaaagt cactgcatct ttgctgaaaa gatcataact aagatctatt
     2161 tctttttgtc tctctagcca tggacttcta tcttggaaat ccaacatacc tgtttctggg
     2221 aaaggacgtg gaacagagca agtctcttct ttctcagact ctaaataata atcttcatag
     2281 acttcatcat caagtagagg acaattaaat cctggatgtc caccaataaa gtaaggcatg
     2341 accttgctag tttctttatt agacttcctg caaaactaaa atcctagttc atgattgata
     2401 ataccagcac tcaaattcat tcgtaatccg aagcgtttac gatgatttcg ataggttgtt
     2461 gaaaacattt taagcgtttt tactttggca aagatgttct caaccttgct tctctcctta
     2521 gatagcacat ggttacaggc tttatcttca gctgttagcg gcttgagttt gctgaattta
     2581 cgtggagttt gtgcttgagg atatatcttc atgagccctt gataaccact gtcagccaag
     2641 attttaccag cttgtccgat atttctgcga ctcattttga acaacttcat atcatgacaa
     2701 tagttcacag tgatatccaa agaaacaatt ctcccttgac ttgtgacaat cgcttgagcc
     2761 ttcatagcgt ggcatttctt tttaccagaa taattcgcta attctttttt tagggcgatt
     2821 gatttttact tccgtcgcat caatcattac cgtgtcctca gaactgagag aagttcttga
     2881 aatcgtaaaa ccactttgaa caagagttac ttcaacccat tggctccaac ggattaagtt
     2941 gctttcgtgg ataccaaaat cagccgcaat ttcttcataa gttcgatatt ctctcacata
     3001 ttgaagagtg gccataagaa ggtcttctag gcttaatttc ggttttcgtc caccttttgc
     3061 gtgtttaagt tgataagctg tttttaatcc agctaacatc tcttcaaaag tggtacgctg
     3121 aacaccaaca agacgcttaa atcgtgcatc agttagttgt ttacttgctt catcattcat
     3181 agaactacta taccatattt tgtttcgcag gaagtctaat attgtcaaat actggaacgc
     3241 tcattgctgg gatacagaat aagattggcc cagcttcgat aactgggata cctggttcaa
     3301 aaccaaggtc tgttgcagcg attggtgtaa agatatcgta acctttcata aggtcttcgt
     3361 ttacatcttt caccatgact gcatcacagt gaacatcata accacggttt gaaagttctt
     3421 cttctagagc acttttaatt tggtgacttg agttaacacc tgcaccgcag gcagcaagaa
     3481 ttttaatcat ttggatttcc tccgatttta ttttttaata gacaagatta agcgattgct
     3541 tcagctatat aagcataaag ggcttctggt tcagaaattt ttgataggtc ttcaagatga
     3601 ccatttcctg tgaaaaagtc catcaactga gccagaatat ttgtttgact tgaacttgag
     3661 ttgttaatga taaagaagag tagggatact tctacttcct tatcaggagc tatcatattg
     3721 tgaaaagtta ctggtttttc taatcgaaca accaccactt tctcagctag attatgaaca
     3781 atatctgtat gaggaatcgc tacatttggc aagtcctttc ctagaaattc catatctaaa
     3841 ccagttggaa atgacttttc acgcgtgatc aaggcttcac gataagttgg agtgacaatt
     3901 tctcgttctt ccaacaagct tgctacctga tcaaagagtt attcttgatt atccgcttct
     3961 aagcaaaaca caaggttttt gtcaaagaaa taatctaata ccataaggtt ttcccttctt
     4021 tccattaact ttatgctata agtataacac tatatgaaat cgttgttaat tactttctat
     4081 tcttttttgt ctcttttttt atatttttgt tttgtttata gtttgttata taaaaataaa
     4141 cacacaaaca aatactccaa gcattttttc tgttctaata ctcaatgaaa atcaaagagc
     4201 aaactaggaa gctagccgta ggttactcaa aacacagttt tgaggttgta gatgaaactg
     4261 acgaagtcag ctcaaaacat gattttgagg ttgtagatga aactgacgaa gtcagtaacc
     4321 atacatacgg taaggcgacg ctgacgtggt ttgaagagat tttcgaagag tataaaaact
     4381 aaaaaagcag accatctaag cctgctttac tattgattct tatataaatt tcctgtgaac
     4441 aaggaaaggc atttctgata acttattctt catccatact caagacgctg aggaaggctt
     4501 cttgcggaac ttcaactgat ccgatggatt tcatgcgttt cttaccagct ttttgttttt
     4561 caaggagttt acgcttacga gaaacgtcac caccataaca tttagcaagt acgttcttac
     4621 gaagggcctt gatatcagta cgagcgacaa tcttgtgtcc aatagccgct tggattggaa
     4681 cttcaaattg ttggcgaggg atgattttct tgagtttatc aacgatgagt ttcccacgtt
     4741 cgtaggcaaa gtccttgtga acgataaagc tgagggcatc caccttatct ccattgagaa
     4801 ggatatccat tttcaccagc ttagatgggc gatattctga caattcgtag tcaaagcttg
     4861 cataaccacg tgtcgaagac ttaagtttat caaagaagtc aaagacaatt tcagcaagag
     4921 gaatttgata gataacattg acacggttat catcaatata gtccatagtc acaaagtccc
     4981 cacgcttacg ctgagctagc tccattactg ctccgacgaa ctcctgtggt accatgattt
     5041 gcgccttgac ataaggctct tcaatggtcg caatcttagt tgggtctgga aactcagatg
     5101 ggttagacac atccatagac tcaccgtcgg tcaaattaac tttgtaaata acagacggag
     5161 ctgtcatgat gaggtcaata ttgaactcac gctctaaacg ttcctggata acatccatat
     5221 ggagaagtcc aagaaatcca caacgaaaac caaatccaag tgcctgagat gtttctggtt
     5281 caaactgaag actagcatca ttcagttgca atttttcaag cgcttcacgc aggtcattgt
     5341 atttgtttga ttcgattggg tagagacccg caaagaccat aggattcatc tgcttataac
     5401 catgtaatgg ttctgccgca ggattggttg ccaaggtaac ggtatcaccc acacgagtat
     5461 cctgaaccgt cttgatagac gccgcaatgt aaccaacatc accagtcgca aggaaatcac
     5521 gaccaaccgc ttttggtgta aaaataccga cttcggccac atcaaaggtc ttactattgc
     5581 tcatgagctg aatcttatca ccaggtttga ccactccgtc catgacacgc acttggagga
     5641 taaccccacg gtaagcatcg taaacagagt cgaaaatcaa ggccttaagt ggcgccgtca
     5701 catcacccgt tggtgctggt actttttcta caatttgctc gaggatttct tcaatcccaa
     5761 taccagcctt ggcagaagcc aaaactgctt cactggcatc caaaccaatc acatcttcaa
     5821 tctctgtacg cacgcgctcc ggatctgcag ccggcaggtc aattttatta atgataggca
     5881 tgatttccaa atcattatcc aaagccagat aaacgttggc aagagtttga gcctcaattc
     5941 cttgagccgc atcgaccacc aaaatagcac cctcacaggc agctagcgaa cgtgaaactt
     6001 cataggtaaa gtcaacgtgc cctggtgtgt caatcaagtg gaaaatataa gtttccccat
     6061 cttttgcagt gtaattcaac tcgatggcat tcaacttaat agtaattcca cgttcccgct
     6121 ctagatccat gctatccaaa agctgggcct gcatttcacg acttgaaacc gtctctgttt
     6181 tttccaaaat gcggtctgct agagttgatt tcccgtggtc aatatgggcg ataatagaga
     6241 agttacggat cttctcctgt cgttttttca attcttctaa gttcatgatt ctcttccttt
     6301 cagggtatct atttattata aattgttttt gatattttga caagaccata ccctgctagg
     6361 agtactaatc ttcagcgaca aagccgtcat tttcgataaa gtggtgttct gtcattcctt
     6421 ggtctgtaaa gacaatcccg tgaagaacac caccataaac agctcctcca tccattccaa
     6481 tcttgccatc ttctgtagtc caaagctcag atgtaccgcg ttcttgctgt aacaaaccat
     6541 agaccggtgt atgaccgaag acaatggttt ttccagtatg attttcagct ccgtggaatg
     6601 gttttctaag ccatactttt ttataatctg ttgtttcatg ccagtcgtcc aaggtcaaat
     6661 caatacctgc gtgaacaaag atatacttgt ctgtctctac tacaaatggc atttgacgaa
     6721 tgaattcgac caagtctgcc gcttcagcgg caacccgctt ggcatcttct actccatcaa
     6781 ctggtgcatc caagggacga cctaggatag agttaatggt tgtatctcca ccattgcgac
     6841 gataatggtc ataactttct tctgggtcat ctagccaagt caaaaacata tactcgtggt
     6901 ttccagacaa acagatagcc ccttgattgt ccacaaagtc cttgaccatt tcaagaacac
     6961 ggtgactatc ctcacctctg tcaatcaaat cacctagaaa gagcaactgg gtctgaccat
     7021 cccaggtttt aagaaggtct tccagcatcc cagcttttcc gtgaacatct ccaattacat
     7081 aataatctgt catcttattt ctccctgttt ctcaacaatt ctctggcttg cgtcagggct
     7141 gcttctgtca catcatcacc tgccaacatc ttggcaactt cctccactcg ctcttcgacc
     7201 gtcaagagac gaacagtcga aaccgttgaa tggtcattac taatcttctc aataaagaat
     7261 tgataatctg caatcgcaat tacttgtggc aaatgggaga tagccaaaac ctgaccatgc
     7321 tgaccaattt tatgaatttt ctgagcaata gcttgagcaa cacgacctga aactcccgta
     7381 tccacctcat caaagacaat actagtcttg ccttctttac gtgaaaaggc agacttaatg
     7441 gctaacatga gacgagataa ttcccctcca gaagcaacct taaccaaggg tttaaagtct
     7501 tctccagggt tggttgaaat ataaaactca accattttat ttccctcacg actgaatttt
     7561 cccttactaa aacgaacctg aaactgggct ttttccatat aaagatcttg cagttcttgt
     7621 ttaatctcag cttcgagttg ctgagccaaa ttatgacgag cagaagcaag ttgacctgcc
     7681 aaattgacaa gattgacttc caacttctta agctctgctt ccatgtcctc agacgaaaga
     7741 ttattgcctg tcaagagatt gtattcttcc gtaatcttgg caaaataaag caaaacatca
     7801 tcaacagtcc caccatactt acgagtaata gtatgaagga ggtccaaacg attctcaacc
     7861 tgcatgaggc gattgccatc aaaatcaagg tcctcaatga tagcttccaa acgtttgcta
     7921 atgtcttcta aaacatagta ggtctcagac agagagcttg aaatttcacg gtattcaggg
     7981 tcatactctt cgacactttc catgtcattc atggctgaac gaacattggc cagacttgaa
     8041 aaatcttcat tgtccaacat actgtaggca ttggtcagtg tatccgcaat atttttgtgg
     8101 ttgaggagtt tatctcgctc ttgattgaga tccaagtctt ctccagcctg caagtttgct
     8161 gcctcaatct ctgccatttg aaattccaac atttcgatac gtgccttgtg ttcctgttgg
     8221 tttttcttga cttccagaac ctgcttgcgc attttccgat aggcatcaaa actcgtttga
     8281 taggtttctt tcaagtccca aaaagcggca tcaccaaatt catccaacat ctggatatgc
     8341 agttggggac gcattaactc ctcatggtca tgctgaccat gaatatctac aagatgttgc
     8401 ccaatagttc gcaaaacaga cagattaacc atctgaccat ttacacggct gatactacga
     8461 ccattttgca agatttcccg acggatgata atttcatcac ctaattctaa accttgctca
     8521 tcaaaaattt cctgtaaaag acgactattc tcaactgaga aaagcccctc aatctctgcc
     8581 tttggtgcac catgacgaat aacatctgtc gtcgcacgag ctcccaacat catattcatg
     8641 gcatcaatga taatcgactt ccctgcaccc gtttcaccag tcaggacagt catccccttt
     8701 tcaaaattga gggaaatagc ctcaataatg gcaaagtttt ttatcgaaat ttcaagtaac
     8761 atatagacct accaattttt tacttgttca aagatttcct ctgctagact tccacttctg
     8821 gcaatgacta aaatcgagct atcatcagtc aaacagctaa aaatcttgtc tgcaaaagtc
     8881 tcgattaact gagcttttac aaaagccgta tttcctggaa taacttggag attgatcatc
     8941 ttatccatca attcagccga ttcgatattg tcttcagcca gttgcagact ttttacgatt
     9001 gattttggca attcgtagac ataggtgttg tctctcaaag gaattttgac aatacctaac
     9061 tctttgatat ctcgggatac cgtcgcctga gtggcagtga tacctgcttc tttcaaatgt
     9121 tctacaattt cttcttgcgt gccgatttga taatctgtca ccaatcttct aattttttca
     9181 agtctttctt ttttattcat ttttaaattg actatgcgcc ctctctactg cttctttaat
     9241 ctcagcaaaa atctgattgc ttgctgactt ttcttttttc aaatacgcta aaaattcaat
     9301 atttccatgt ccaccttgga tgggagaaaa gtccaagcca aggactgaaa aacctgcctc
     9361 tactgccata gctgttacag attcaaggac attctgatga atcttagcat ctcgaataat
     9421 tccatttttc ccaatctgct cacgtcctgc ctcaaactga ggtttgacaa gtgctaccac
     9481 ctgaccttga tcagccaaga cacgatgcaa ggctggcaaa atcagactaa gggaaatgaa
     9541 actcacatca atactggcaa agctcggctc ctgctcgaaa tcagtctttt cagcatagcg
     9601 aaaattgaac tgctccatgc tgacaactcg tgggtcttgg cgtaatttcc aagccaactg
     9661 attggtacca acatcgactg caaagaccaa cttggcacta ttctgtagca tgacatcggt
     9721 aaaacctcca gtagaggccc cgatatcaat cgtagtcgcg ccatccaccg acaaatcaaa
     9781 gacctgcaag gccttttcca gtttcaaacc accacggctg acatacttga gtttctcccc
     9841 cttgagtttt aattcggtgt catctggaat tttctctcct ggcttgtcaa accgttctcc
     9901 attaaggact gctacgacta ggccagccat cacacctcgc ttggcctgct ctctcgtttc
     9961 aaacaagcct tgtttataag ctagtacatc cactctttcc ttagccattg attctcaaac
    10021 tttctactac acttacaatc gattctgttt caaagggaag ctgctgggca atttcttcta
    10081 atttttcatt agcttgatcc agggtttggt tacaaaaggc aatggactct tccaagccca
    10141 acaaggcagg ataggttgat ttttctgcct gcagatcctt ttgaggtgtc ttgccgattt
    10201 cctcaaaact agctgtcaca tccagtacat catctctgac ttgaaaagca agtccaatca
    10261 attcacccac agttttcagc ttcacctgca tttcaggtga caattcagct ataatagctg
    10321 ccgcttggaa gggataggct agtaacttcc cagtcttatt ggcatgaata gtctgaagtt
    10381 cttccagaga caagtgctgg tgttcgccct ccatatccaa aacttgccct gccaccatac
    10441 ccagactacc tgaagcaagg gataagttgg caatcaagtc caccttgatc tgacttggca
    10501 aatctgcctg cgcaatcaaa gcatatgggt ctaagaataa ggcatctcca gccaaaatgg
    10561 ccatagcttc accgaatttc ttgtgattgg ttaaccgccc tcttcgataa tcgtcatcat
    10621 ccatagcagg aaggtcatcg tgaatcaagc tccctgtatg aatcatctcc aaggcagtag
    10681 ctacctgcgc gtgagcaggt ttgatggcaa cctgcaaggc ttccagaact tctaacaaga
    10741 gaaaaggccg aatacgcttg ccaccagcat gaatagaata gagaacagac tcccgtaaac
    10801 tagaggcaaa ctgctggtct ccataaaaat cttccaaagc cgactcgaca agagctaatt
    10861 tttcttgctt tttcattcaa aatcactttc tgttccgtct tcttgcatga cctttaccaa
    10921 ggtcttttca gccttgtcca gcgtagcttg gagctctttt gacaagacca tgcccttttg
    10981 aaaggcagta atcgcatctt ccagagcaat ttcaccattt tccaaacttt ggacaatggt
    11041 ttccagttct gctagatttt cctcaaattt cttttgtttt gacatcttta acctctaatt
    11101 ctacttgacc atctcgcatc aaaagcgtta cttggtcttt tttcttcaaa ctctcaaccg
    11161 aatctacaac ggactcttct tttttgacaa tagcataacc acgcgccacg attcggctag
    11221 tatccaacat gagcaaagct tccgaaagtc gcttggcctc agcaaccttg gcgtcataaa
    11281 ctaacgccat ttggctacct aagagcttgt ccaactgtcc taaacggtct tgatagcgtt
    11341 ggattttggt aacaggtgat aattgtacta attgatgagt tcttgcttga actaattgtt
    11401 tgttatcaga aatccgagtt cgcaaacttt gtttcaaacg cagttgcagt tggtccaagc
    11461 gttgcaaata accgtcatac aagcgctcag gttgtctaaa gataacagac tgactgcatt
    11521 ttttcaaagc ctcttgtttc ttagatagaa catttcggac tgccgttgcc atccgttttt
    11581 cctgattttg caaatgagct aatacatcca acttggtcac aggtgttgcc agttcagccg
    11641 ccgctgttgg tgttgcagcg cgtcgatctg ccacaaaatc tgccaaggtc acatccgtct
    11701 catgccccac actagagata actggcaaac gagattcaaa aatagctcgt accacaattt
    11761 cttcgttaaa ggcccagaga tcctcaatag aaccacctcc acgaccaata atgagcaaat
    11821 ccaaatcgtc ccgttgatta gcacgcgcaa tatttctagc aatttcctcc gcagcccctt
    11881 caccttgaac cttggtcgga taaagaagga tgtcaacacc tgggaatcgc ctgctgacgg
    11941 tcgtgataat atctcgaata acggctccac tacggctggt tactacacca attctcttag
    12001 aaaattgggg cagagcttgc ttgaagcgtt cttgaaacag gccttcttct gtcaattttt
    12061 tcttaagttg ttcaaactga atcgcaagcg ccccaacccc atcaggctca gctttttcaa
    12121 tgatgatgga gtagctacca cttggttcat agacctgtac acgcccaatc acattgatct
    12181 tcattccttc ttccaggtca aaccctaatt tctgataaat cccagaccag atggtcgctt
    12241 gaataactgc atggtcatcc tttagggaga aatattggtg agtaggtcgt ttacgaaagt
    12301 tggaaacttg accagttaaa tagacccgtt ccaagtatgg gtctttatcg aatttcattt
    12361 tcagatactt ggtcaaagtt gttaccgata aatacttttc catctccacc tactattcat
    12421 ttacttgctc tttcatgggt attattatac caaaaatatg cctaaaaatc tccatttatg
    12481 taccgttatg agggaaaaat agaaaaagga ggcaaggcct ccacatgtga ttatttgctg
    12541 attcgagctt cttccaaaat ctttgcaatc ttggtcgtca acaggtcgat agccacggta
    12601 ttgctaaccc cttcaggaat gacaatatca gcataacgct tagttgactc gataaactgg
    12661 tggtacattg gtttaaccac acctaagtac tggttaataa cgctatcaag gctacggcca
    12721 cgctcctcca tatcacgctt gatacgacga ataatgcgca catcgtcatc cgtatccaca
    12781 aaaatcttga tatccatcaa atcgcgcaga cgcttgtcct ccaagaccaa aatgccctca
    12841 acgataaaga catcttgagg ctcctgacga taggtcttgc tactccgtgt atgctctgta
    12901 tagtcgtagg tcgggatgtc caccggacgc cctgccaaca attccttaat ctgctcgatc
    12961 atcaagtctg tatcaaaggc aaaaggatgg tcatagttgg ttttgacacg ctcttcaaag
    13021 gtcaaatgag actgatcctt gtagtatgaa tcatgctcaa tcatggaaat cttttcatca
    13081 ggaaaatgcg ataaaatggc tcttgaaaca ctggttttac caccaccaga accacctgtc
    13141 actccaataa tgattggtct attttgcatg ctatcctccg ttattttatc cgtcgtctat
    13201 tctatcacat tttttacaaa atttatagtc tcatcagcaa aaaacaccag agtcttccct
    13261 ctgatgttcg acaattttaa cgaaagccct gtagggtttg agcaagcatc tgcaagaaag
    13321 ccagtctccc tctttcctgg ctaggagctt tggcaatcca taaaccaaaa tcaatgacag
    13381 acttaggtgc ctggtaatga tgcgtcatga ggtaaagtga caacccttga ctcaaattgg
    13441 ccatgaccga ttggtatttt tcatttctat ctaaattttg tatagcaaga cgaaacaggt
    13501 gactcaactc actattttca tttatttctt tttgttgaag aagttgctcc accctttctc
    13561 gaaactcatt tcgcatcatg gaattatcac accaaatcct gggcctaagt tcccaccaga
    13621 acctgtaatg gactctaaat atttatctga aagaatttta agttgcttca tttcacacct
    13681 ctaaatttct atatagatta tttgagtatc tacaactcgc aacaattgga atattataat
    13741 tcccaaaacc attctactat tagtatgggt attagtatgg gattttatca agcaattgtt
    13801 atctatcacc cgatttttat tcctaaacga tctagctaaa aaccttcctt ggcttataga
    13861 gattgcccca tttttctaga atggctaaca atttatcatc ttcaaaggca gccagttctt
    13921 tgtccgtttg gtctagctca ataaaacgac caaagcgaac ttctgtagcc tcttctggag
    13981 ttaggaaaac tttgacaagg tcacctgtcc caatctctaa aggatggaga aaatctaatt
    14041 gcccagcctc tactttttca gcaatttcct ccaaggtaag agcgtcttct aattgtaagc
    14101 cagcagcact agtacgagtc aaatgggaca tatgagccgc ataaccaagc ttttcaccca
    14161 aatcaactga caaagtacgg atgtaagtcc ctttactgca ttttacacga aaagtgaatc
    14221 gggcaagttg gccatcataa gaaatcggac ttgttcgctc aaattgataa atggtcacct
    14281 gacgttctgg acgctccact tcctgaccag cacgcgcata ctcatagagc ttgcgaccat
    14341 taaccttaac tgccgaatac atagggggaa tctgggtaat aggcccagtc aagctagcaa
    14401 tcgcttcatc aacaagcttt tcatccaagg gagacaaaac aggggtttct gcgatcactt
    14461 ccccactagc atcctcagtc gtcgtggaat aacccagagt aatttccccc tcatagatct
    14521 taccctcgtc ctgcataaac tcgaccatgc gtgtcgcctt gccaaccgca atcggcaaaa
    14581 cacccaccac atccggatcc aaggttccac catgaccaat tttcttggtt cccaaaatct
    14641 tacgcagttt aaaaaccgca tcatgcgagg tcattcctgc ttcttttttt aagttgataa
    14701 taccgttcat ttttgctttc tactccccct tcagtgcttc gaacttcgct ttcattgttg
    14761 gatttttccg ggtcaatttt ttaacagaga catcttccaa tttgttgtta gctagacgga
    14821 gttggttttc agatgtggtc aggaatttct taacctcttc catgcgtttg atggccttgt
    14881 cgatttcatc aatagctttt ccaaagttag tcgaagctga attatagttc ttagcaaaag
    14941 ctagcttaaa ggcatccaaa tcttcctcaa aatgcgtaat gtcaatattt tgctcgcgaa
    15001 ccaaggccaa ctcctgcttg tattttaggg aatttagcgc cgcattacgt aagagaccaa
    15061 tcaactggat aaagaattga ggacgaacaa catacatttt ttcatactcg tggctgacgt
    15121 caacaatccc tgtgttaaag tagtcattat cagcctcaag catggtcacc aaaacggcat
    15181 actcacagtt cttctcccga cggtccttgt ccaattcctt gtaaaaatct gcattcttgt
    15241 gcttcttctc tgttccgtcc gcttcgtttt tcatctcaaa catgatagaa atgatttcaa
    15301 ctccattttc atcacactca cggaagataa agtccccttt agacccacgc gaagagacct
    15361 tgttatcctt ctcaaagtaa gcatttggaa aggcgaaact acgaaccttg ttaaactcac
    15421 tctctgcata ctgttctagg ctttccccaa tcgcttttgt agattgttga gccttaaaat
    15481 tcttataaaa ctcgacttgt tcactggctg ctttgagctg ggcttcgtag ttttgcttaa
    15541 cagaagccaa agacaactca ttttcctttt cttgcagtag gagctgattt ttgacctgat
    15601 tgcgttcttt ttctaggtca gaaagggtct tttgcaattg attttcatgc tccaaacgca
    15661 aggtcgccaa ctggttttcc aaggcctgta cttccttgtc cttagccaag agagcctgat
    15721 ggcttgtctg ttcaacttct ttcttggcca attctttttc tgtatcaaag ttttggatct
    15781 gactctgtaa ttgcgcaatt tcttgatcct tctgagccag tttagtctgt tgctcattca
    15841 tagccttttg ctcagccaag gccagttcct gcctcatcct atcgtgtagt tccttatcaa
    15901 actctgccgt tctcacttgg gacaaaagtt cagcatactg gctttcattc actgtaaaga
    15961 cttccccaca gttgggacat ttgatttcgt tcattacatc cctctttcta gacttctgta
    16021 accattatat catgcatgaa ggaaaatcaa aaacagcgag tcgaaaacca ctgtttatct
    16081 tctttttctt taaatttttt ccaaggtcaa gcgcaagtct tcaatcaaat cttctacatt
    16141 ttcaagaccg attgacaaac gaatttggtt tggtgtgaca cctgctgctt ctaggtcttt
    16201 ttctgacaat tgaccgtgag tggttgttgc tggatggaca acaagcgatt tagcatctgc
    16261 cgcgtttgca aggtcagaaa agatttctaa atgatcaatg accttgcgtg cttcttcctc
    16321 gccacctttg acatggaagg taaagattga accgacacct tttggcaagt atttctcagc
    16381 caaggcatga taaggactat ctgcaagttt tggataattt accttttcta ccttaggatg
    16441 gtttacaaga aaatcaacaa ttgtctcagc attttgtaca tggcgttcca cacgaagtga
    16501 aagggtttca agtctttgta gcaagaggaa agcattgaat ggtgacaagg ctgcacctgt
    16561 atcacgaagc aattgaactc gaacagctat aataaaggct gctgcaccca catcacgagt
    16621 ataattcaaa ttgtggcagc ttggaccctc gtcaacaaat tgagggaatt tccctgaagc
    16681 cgtccagtca aaacgaccac tatcgacaat tattcctcca atagttgtac catgcccacc
    16741 gataaactta gtcgcagagt gaatggcaat gtcaacgcca tgagagaaga cgttaatcaa
    16801 ataaggtgtt gcaaaagtat tgtctgacac aagtgggatt tgatgtttat gagcaatctc
    16861 tgccagtttt tccaggtctg gaatattaat caaggggtta cccaaggttt caatcaagac
    16921 aagcttggta ttgtctttga tagctgcttc tacttcctcc aaattatcaa tatcgacaaa
    16981 ggttgttgtg ataccataac gaggaagggg ttctttcaaa agattgaagg ttccaccgta
    17041 aatagtcgaa gcagccacta catggtcacc agcatgggca atcgccaaaa tagtataagt
    17101 cactgcagtc atacctgatg ctgttgctag cgcttcaaca ccaccttcaa gggcagctgt
    17161 tgtaggattg gtgatacgag tataaatgtt ccctggtttc ctcaaggcaa acatatcggc
    17221 accttcctac gtgtcatcaa aaacaaaaaa tgttgtttga taaatcggca ctgcacgaga
    17281 cttagtagct ggagccacaa cttgaccagc atgtagttgt agagtttcaa atttaaaatc
    17341 acaagtcata aggtgacctc catattattt tattaaggat attgtagcac cttgagttat
    17401 agtttacaaa tatcagtttt ctatattttg atataagaaa tagctgttac cttattttga
    17461 aaatgaaaaa agcacgactc aatcgtgctc attttcttaa tctacataag tatcttcgtt
    17521 tttattgagg aaggcatatg gaagacccat caagaggcct cctccgataa agtttccgat
    17581 gaaagtcaca ccccagtggc gaagcatatt tccaacaccg aagttggcaa ttgaatccgc
    17641 agcaacactg aatttcacaa tcgcgaaaga agcaaagttc gccgcaatgt gctcgtttgt
    17701 taagaataca aacatgtaaa tagctgacaa cacaagccaa agtttggcac caccatcttt
    17761 gaccaaaata aatgacagaa tcgcaatatt tacgaaaata tttgccaaaa ttgcctcaag
    17821 caagaccaat tcatttgagc ggcctaactt catctcaaca acacctgaga tgaaactatc
    17881 gtgtatcaga ttcgcatagg ctgccgaatg agcaaagccc caccctgcta tcaaggctcc
    17941 gataaggttg aacaaggtac agtatagtaa aatctcagct gtttttctcc aagagatttt
    18001 ttttaagaaa ctaccagcag tcaagaacat catgtttgaa gtgaccaact cggcattcaa
    18061 aaaaacaatg taggccaagc cccaagcaaa aacgaatgga aagaggaagc gtccactacc
    18121 tggtgcaatt ttattaatca agtcagctcc aactgcacct gcagcagtac tgaaggttaa
    18181 aaatgcacct gcgaacatcg aacgaatcgc atacttaaat ttgctttgac tataaagact
    18241 ttctttctta ttgcaagcaa attcaatctt tgaaataaat tctgaagaaa ccataataaa
    18301 ctcctaaatc ttttttcttg ataattatat cacaaacttt aggttttagg aagcgttttc
    18361 tgtatttcat aaaagtttat agtagattga aactagaata gtacacctct acttctaaaa
    18421 cattgttaga aatcgatttg attgtcctga acgattcgtc ctattcttat ttcattttac
    18481 tatattttta tgaaaatctt aaaaaatcag tgaaatcatg gatttcactg atttgtatta
    18541 ataaaattgt ttatatggtt gattgaaagc tgttaggatt tcatcagatg tttgtgaata
    18601 atcttttgtt tctttcaaat cacctttgac aataatacgt tctgtagcag caaggtcttc
    18661 acaggttact aatgtgattt cattgacccc atctctatca tcaacttcat caacacgatc
    18721 cggtgtcaca cgtttgactt cacgtatttc ataagtataa actttatttt tatcggttag
    18781 ataaatcttc atgccatttt tagcattatc taaaggagaa aataacattt tattagcatt
    18841 atcaacacca aagatatggt gactagctag actataattt ccttctccca ttacttgctc
    18901 gcgtttcatt gtaccagctc cgtagaagag attaacatta tcaagtcctt taaaaatcgg
    18961 caaattcatt tccaattcag gaattgcaat tcccccaata actggtaatt tttgagcatc
    19021 ccattgagaa gttagaacag cttccgaaga gatagctttg acagaatcaa agtcaaaatt
    19081 gccttctgta tcctgatttt cttctaattt ttcttttgat acctggctaa cttgatactt
    19141 attggtattc cagactatga aaatatttcg aatttgagta ttaaaaatca aagccagtga
    19201 cagtaatatc agaaatcctg ctaggatatt tgtcagcaaa ttttttcgct tgtttttctt
    19261 tttattattt ttttgagaca ttatgcttca ccttctgttt cgttttctgt cccaacttct
    19321 tctttttctg ccaccgcaac cgttgtgaaa gtcactatct gagcatcttg atccaggcgc
    19381 attactttaa ctcccatagt tgcacgtcct gtttgtgaaa tattggcaag attggttcga
    19441 atcatgacac ctgtatcagt gataatcatc aaatcctcat ccccttgaac agtcataaga
    19501 ccggccagca agccattttt ttcggtaatt ttagctgtct gcattccctt accaccacga
    19561 ccttttgttg ggtattcagt agcgactgta cgcttaccat atcctttttc tgtgataaca
    19621 agaacctcat cttgatcagt aatcaagctg gcaccaacaa ctgtgtctcc ttcacgaagg
    19681 ttaacacctt tcacaccagt ggcgatacgg ctcataccac gaacggctga ttgattaaag
    19741 cgaactgcat aaccaaactt ggtaccaatg ataatatcca tatctccttc tgccaacaag
    19801 acattgatta actcatcttc atcctttaaa ttcagcgctt tgagaccatt ttgacgaata
    19861 ttggcaaact ccttaacact ggttctcttc acaataccgt gacgggttgt aaagaagaga
    19921 taagcatcat cactgcgatc agactcaaca ttgataaccg tctgaatact ttcgtcttca
    19981 tccaatttca agagattgac tactggtagc cctttggcag tccgaccata ctcaggaatt
    20041 tcataacctt taagacgata gacacgtccc ttgtttgtga agaagagcag atgatcatgg
    20101 gtgctagttg acactaactc acgaacaaag tcatcatctt tcactcccgt tccttggaca
    20161 ccacgacccc cacgtttttg agcagtgaac tcgtcctgat ctaaacgctt aatgtagcct
    20221 ctgttagaaa gggtaatcaa gacatccgat tcttcaatca agtcctcatc ctcgagactc
    20281 aagacctgtc caaccatcaa ctctgtacgg cgtttatcag aaaatttacg tttaacttca
    20341 tccaattcgt ctttgataat ttgagaaaca cgttcaggct tagcaagaat atctgctaaa
    20401 tccgcaatca gagccaagag gtcatcatac tcagattgaa tcttatcgcg ttccaaacct
    20461 gtcaaacgac gaagacgcat atcaaggata gcttgacttt gacgttcaga aagcttaaac
    20521 ttgctcatca actcagcttg agcttccgca tccgtttcac tagcacggat gatacgaatc
    20581 acttcgtcga tatggtctag cgcaatcaag agaccttcta agatatgagc gcgcgcttcc
    20641 gctttttcct tatcaaaacg tgtacgacga acaaccactt ctttttggtg ctcgatataa
    20701 gcatccaaaa tctgacgaag agacaaaatt ttcggtatac cattttggat agcgagcata
    20761 ttgaaaccaa aattggtttg catttgggtc attttgaaga ggttattgag aataacattg
    20821 gctgaggcgt cgcgcttgac ttcaataaca aatcgaacac cttcacggtt tgactc
//
