LOCUS       NZ_FIXU01000013        17858 bp    DNA     linear   CON 15-DEC-2024
DEFINITION  Streptococcus pneumoniae strain B18210a, whole genome shotgun
            sequence.
ACCESSION   NZ_FIXU01000013
VERSION     NZ_FIXU01000013.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1
  CONSRTM   Pathogen Informatics
  TITLE     Direct Submission
  JOURNAL   Submitted (09-FEB-2016) SC, Wellcome Trust Sanger Institute, CB10
            1SA, United Kingdom
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_900052895.1-RS_2024_12_13
            Annotation Date                   :: 12/13/2024 02:58:16
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.9
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 2,298
            CDSs (total)                      :: 2,246
            Genes (coding)                    :: 2,088
            CDSs (with protein)               :: 2,088
            Genes (RNA)                       :: 52
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1, 1 (5S, 16S, 23S)
            tRNAs                             :: 46
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 158
            CDSs (without protein)            :: 158
            Pseudo Genes (ambiguous residues) :: 0 of 158
            Pseudo Genes (frameshifted)       :: 62 of 158
            Pseudo Genes (incomplete)         :: 91 of 158
            Pseudo Genes (internal stop)      :: 44 of 158
            Pseudo Genes (multiple problems)  :: 32 of 158
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 13:33:22
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 33746
            Orig. end                         :: 51604
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            FIXU01000013.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..17858
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RiPP-like"
                     /region_number="1"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..17858
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..17858
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[5000:12858](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..12858)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     misc_feature    complement(1065..1075)
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 18.94"
                     /tool="antismash"
     misc_feature    complement(1821..1835)
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 21.98"
                     /tool="antismash"
     misc_feature    2533..2546
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: medium, score: 22.09"
                     /tool="antismash"
     gene            complement(2641..2751)
                     /locus_tag="A1M11_RS13820"
     CDS             complement(2641..2751)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000429437.1"
                     /locus_tag="A1M11_RS13820"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="phosphoribosylaminoimidazolesuccinocarboxamide
                     synthase"
                     /protein_id="WP_078065395.1"
                     /transl_table=11
                     /translation="MENLRLSTKRTQAEKVPQTFSLCRELGELTDVYEIV"
     gene            complement(2762..3469)
                     /gene="purC"
                     /locus_tag="A1M11_RS07160"
                     /old_locus_tag="ERS050419_01398"
     CDS             complement(2762..3469)
                     /EC_number="6.3.2.6"
                     /GO_function="GO:0004639 -
                     phosphoribosylaminoimidazolesuccinocarboxamide synthase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006164 - purine nucleotide biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /gene="purC"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000043309.1"
                     /locus_tag="A1M11_RS07160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS050419_01398"
                     /product="phosphoribosylaminoimidazolesuccinocarboxamide
                     synthase"
                     /protein_id="WP_000043300.1"
                     /transl_table=11
                     /translation="MSKQLIYSGKAKDIYTTEDENLIISTYKDQATAFNGVKKEQIAGK
                     GVLNNQISSFIFEKLNAAGVATHFVEKLSDTEQLNKKVKIIPLEVVLRNYTAGSFSKRF
                     GVDEGIALETPIVEFYYKNDDLDDPFINDEHVKFLQIADDQQIAYLKEETRRINELLKV
                     WFAEIGLKLIDFKLEFGFDKDGKIILADEFSPDNCRLWDADGNHMDKDVFRRGLGELTD
                     VYEIVWEKLQELK"
     gene            complement(3639..4988)
                     /gene="comB"
                     /locus_tag="A1M11_RS07165"
                     /old_locus_tag="ERS050419_01399"
     CDS             complement(3639..4988)
                     /codon_start=1
                     /gene="comB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000801614.1"
                     /locus_tag="A1M11_RS07165"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS050419_01399"
                     /product="competence pheromone export protein ComB"
                     /protein_id="WP_000801609.1"
                     /transl_table=11
                     /translation="MKPEFLESAEFYNRRYHNFSSSVIVPMALLLVFLLGFATVAEKEM
                     SLSTRATVEPSRILANIQSTSNNRILVNHLEENKLVKKGDLLVQYQEGAEGVQAESYAS
                     QLDMLKDQKKQLEYLQKSLQEGENHFPEEDKFGYQATFRDYISQAGSLRASTSQQNETI
                     ASQNAAASQTQAEIGNLISQTEAKIRDYQTAKSAIETGASLAGQNLAYSLYQSYKSQGE
                     ENPQIKVQAVAQVEAQISQLESSLATYRVQYAGSGTQQAYASGLSSQLESLKSQHLAKV
                     GQELTLLAQKILEAESGKKVQGNLLDKGKITASEDGVLHLNPETSDSSMVAEGALLAQL
                     YPSLEREGKAKLTAYLSSKDVARIKVGDSVRYTTTHDAGNQLFLDSTITSIDATATKTE
                     KGNFFKIEAETNLTSEQAEKLRYGVEGRLQMITGKKSYLRYYLDQFLNKE"
     gene            complement(5001..7154)
                     /gene="comA"
                     /locus_tag="A1M11_RS07170"
                     /old_locus_tag="ERS050419_01400"
     CDS             complement(5001..7154)
                     /codon_start=1
                     /gene="comA"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: TIGR01193"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000668284.1"
                     /locus_tag="A1M11_RS07170"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS050419_01400"
                     /product="peptide cleavage/export ABC transporter ComA"
                     /protein_id="WP_061747159.1"
                     /sec_met_domain="Peptidase_C39 (E-value: 1.4e-43, bitscore:
                     140.0, seeds: 36, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR01193 (E-value: 0.0, bitscore: 1125.6,
                     seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKFGKRHYRPQVDQMDCGVASLAMVFGYYGSYYFLAHLRELAKTT
                     MDGTTALGLVKVAEEIGFETRAIKADMTLFDLPDLTFPFVAHVLKEGKLLHYYVVTGQD
                     KDSIHIADPDPGVKLTKLPRERFEEEWTGVTLFMAPSPDYKPHKEQKNGLLSFIPILVK
                     QRGLIANIVLATLLVTVINIVGSYYLQSIIDTYVPDQMRSTLGIISIGLVIVYILQQIL
                     SYAQEYLLLVLGQRLSIDVILSYIKHVFHLPMSFFATRRTGEIVSRFTDANSIIDALAS
                     TILSIFLDVSTVVIISLVLFSQNTNLFFMTLLALPIYTVIIFAFMKPFEKMNRDTMEAN
                     AVLSSSIIEDINGIETIKSLTSESQRYQKIDKEFVDYLKKSFTYSRAESQQKALKKVAH
                     LLLNVGILWMGAVLVMDGKMSLGQLITYNTLLVYFTNPLENIINLQTKLQTAQVANNRL
                     NEVYLVASEFEEKKTVEDLSLMKGDMTFKQVHYKYGYGRDVLSDINLTVPQGSKVAFVG
                     ISGSGKTTLAKMMVNFYDPSQGEISLGGVNLNQIDKKALRQYINYLPQQPYVFNGTILE
                     NLLLGAKEGTTQEDILRAVELVEIREDIERMPLNYQTELTSDGAGISGGQRQRIALARA
                     LLTDAPVLILDEATSSLDILTEKRIVDNLMALDKTLIFIAHRLTIAERTEKVVVLDQGK
                     IVEEGKHADLLAQGGFYAHLVNS"
     misc_feature    7436..7449
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: strong, score: 24.43"
                     /tool="antismash"
     gene            complement(7534..8025)
                     /locus_tag="A1M11_RS07175"
                     /old_locus_tag="ERS050419_01401"
     CDS             complement(7534..8025)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000671992.1"
                     /locus_tag="A1M11_RS07175"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS050419_01401"
                     /product="hypothetical protein"
                     /protein_id="WP_000671990.1"
                     /transl_table=11
                     /translation="MKFQTNNSLYKLMNLIIYLFLLYLFIDLLMKSGILDEQIDKLSEL
                     SNLFTIKIETILTVISVVFTFIATLIEYGFSLFLITLFFDKNKRNFGDILLSKNITLSF
                     SILLCYLFNPSDIKFAYFSVLTVLLIGITNYARFKNLRLTVVFSVPFLFNAIMSIINSF
                     "
     gene            complement(8006..8602)
                     /locus_tag="A1M11_RS07180"
                     /old_locus_tag="ERS050419_01402"
     CDS             complement(8006..8602)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000687786.1"
                     /locus_tag="A1M11_RS07180"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS050419_01402"
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="WP_000687787.1"
                     /transl_table=11
                     /translation="MKIENESKSYDKCILKNISLEIDKGIYRVEGENGSGKSTLLQLLA
                     GLETFDSGLKNCVSKDVLYLDTNQLGVVPFTIEENLQLLCDSFQIHLSFEDKEQINTFF
                     DNKIGDNYMTASTGTKFKLGLSLIFAKNWDYIFIDETLSTVDARSIDMIAKRLISMKES
                     STIIYVSHNLLNQELISKSQRILIEEGRVYEISNK"
     gene            complement(8599..9081)
                     /locus_tag="A1M11_RS12195"
                     /old_locus_tag="ERS050419_01403"
     CDS             complement(8599..9081)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001232094.1"
                     /locus_tag="A1M11_RS12195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS050419_01403"
                     /product="stage II sporulation protein M"
                     /protein_id="WP_001232094.1"
                     /transl_table=11
                     /translation="MRKSGFLIYYVLFCIVCFLLGLLLSFILKNETFATIPPKLELQFT
                     LTVLQANSTNFLLYLFCFPISPLLQLFDLLSLGIQLGISGQMIGIVATIKGILPHALIE
                     IPNFIWYQGMSQYLLYRLLKDRGIKNILIYIKSNLKWYIISYLLLILAALIEGIKL"
     gene            complement(9078..10214)
                     /locus_tag="A1M11_RS07190"
                     /old_locus_tag="ERS050419_01404"
     CDS             complement(9078..10214)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000698829.1"
                     /locus_tag="A1M11_RS07190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS050419_01404"
                     /product="hypothetical protein"
                     /protein_id="WP_000698828.1"
                     /transl_table=11
                     /translation="MKILSKKECESILGYLNFIGITLLFFVIISLSIYFKSYLPFQGKL
                     FLLFLVVDYATLNRYNMKLPIQSKKINTFYIRKNYIFLYLLAIVKKYYSFQILQSFIYL
                     FILYFLDIIGYFYLSITLCLIAIQIISLILPSLFSIISKLFLFLSIGLLSIEQGQVVIY
                     VILLNYFILVMGILDNHASNFYFKSSRMSQKRFRSSLFILLRFCWLNKGLTFSFILISI
                     LLSYLFWYMMTMLSIDDTKIPILFLYTSIYITLMEAIIGNHKSSIGVDLALLQLSALNH
                     SKMNFFFKNAQLMMLTHLISFLQFSLLLCLIPVTSYSNDIKSILLNLLLIPFNYFIAYV
                     YYKKALFLIKGTVSLLRWSFLVLYCFLIIFVILVGGIR"
     gene            complement(<10271..10450)
                     /locus_tag="A1M11_RS07195"
                     /old_locus_tag="ERS050419_01405"
                     /pseudo=""
     CDS             complement(<10271..10450)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Bacteriocin_IId"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000837727.1"
                     /locus_tag="A1M11_RS07195"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="ERS050419_01405"
                     /product="uberolysin/carnocyclin family circular
                     bacteriocin"
                     /pseudo=""
                     /sec_met_domain="Bacteriocin_IId (E-value: 2.3e-10,
                     bitscore: 32.7, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKSKRMEFHNKFLIVSAMLAVISWLSLGVVSFPMLAGTLGISTKA
                     AATVVNLISAYSTVT"
     misc_feature    complement(10918..10929)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: medium, score: 18.13"
                     /tool="antismash"
     gene            complement(10981..11874)
                     /locus_tag="A1M11_RS07200"
                     /old_locus_tag="ERS050419_01406"
     CDS             complement(10981..11874)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000343891.1"
                     /locus_tag="A1M11_RS07200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS050419_01406"
                     /product="XRE family transcriptional regulator"
                     /protein_id="WP_000343888.1"
                     /transl_table=11
                     /translation="MDELKREIGYKIKTIRRSCGKTQIDICGDESELTIRQLARIENGQ
                     ALATLPKLLLIADKLGVSLQNIVDVKVIEIPKGFLKLKDELIHSQTYADKGRIERKEAI
                     LEEIYENYYENLPEEEQLIVDVTQARFDIYGSSDVTYGLGLVEEYFQQLLKKKYFSVND
                     LLIIELYFFCCAMGLEDKEHFEELAQKVLLCSEYEDKASLVQMEKVLLSLFIQIQTEDS
                     LIYIQTFEKIIAKTRHVFYRPHLFLLKAKYALFVDKNILEAESFYEKAISLAELLDDQV
                     LVQRILAEKQIDFPTT"
     gene            complement(11895..12089)
                     /locus_tag="A1M11_RS13490"
     CDS             complement(11895..12089)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000757183.1"
                     /locus_tag="A1M11_RS13490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_000756776.1"
                     /transl_table=11
                     /translation="MKKVLKYFLVFVFLFLMNIFIFKILATLGFQLIMSEKSYIVLPLF
                     SLIVLYMIDKRIRKKKKSL"
     gene            complement(12500..12625)
                     /locus_tag="A1M11_RS13495"
                     /old_locus_tag="ERS050419_01407"
     CDS             complement(12500..12625)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001842754.1"
                     /locus_tag="A1M11_RS13495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS050419_01407"
                     /product="PncF family bacteriocin immunity protein"
                     /protein_id="WP_000346297.1"
                     /transl_table=11
                     /translation="MDFKSFIIGLVVGIFGPYMDDLIRKKFLKSSEKKTEKSVKK"
     gene            complement(12628..12858)
                     /gene="blpU"
                     /locus_tag="A1M11_RS07210"
                     /old_locus_tag="ERS050419_01408"
     CDS             complement(12628..12858)
                     /codon_start=1
                     /gene="blpU"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Bacteriocin_IIc"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001093487.1"
                     /locus_tag="A1M11_RS07210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS050419_01408"
                     /product="bacteriocin-like peptide BlpU"
                     /protein_id="WP_001093487.1"
                     /sec_met_domain="Bacteriocin_IIc (E-value: 1.6e-17,
                     bitscore: 55.9, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNTKTMSQFEIMDTEMLACVEGGGCNWGDFAKAGVGGGAARGLQL
                     GIKTRTWQGAATGAVGGAILGGVAYAATCWW"
     misc_feature    13006..13019
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: medium, score: 22.31"
                     /tool="antismash"
     gene            complement(13061..>13360)
                     /locus_tag="A1M11_RS07215"
                     /old_locus_tag="ERS050419_01409"
                     /pseudo=""
     CDS             complement(13061..>13360)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001105201.1"
                     /locus_tag="A1M11_RS07215"
                     /note="internal stop; incomplete; partial in the middle of
                     a contig; missing N-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /old_locus_tag="ERS050419_01409"
                     /product="transposase family protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="LEMRNIGQAGKILADSGY"
     gene            complement(13397..13630)
                     /locus_tag="A1M11_RS07220"
                     /old_locus_tag="ERS050419_01410"
     CDS             complement(13397..13630)
                     /NRPS_PKS="Domain: PP-binding (8-72). E-value: 3e-11.
                     Score: 35.5. Matches aSDomain:
                     nrpspksdomains_A1M11_RS07220_PP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000136447.1"
                     /locus_tag="A1M11_RS07220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS050419_01410"
                     /product="acyl carrier protein"
                     /protein_id="WP_000136447.1"
                     /sec_met_domain="PP-binding (E-value: 5.3e-12, bitscore:
                     38.3, seeds: 164, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding_2 (E-value: 1.9e-05, bitscore:
                     17.1, seeds: 2, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTEKEIFDRIVTIIQERQGEDFVVTESLSLKDDLDADSVDLMEFI
                     LTLEDEFSIEISDEEIDQLQNVGDVVKIIQGK"
     aSDomain        complement(13415..13606)
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_A1M11_RS07220_PP-binding.1"
                     /evalue="3.00E-11"
                     /label="A1M11_RS07220_PP-binding.1"
                     /locus_tag="A1M11_RS07220"
                     /protein_end="72"
                     /protein_start="8"
                     /score="35.5"
                     /tool="antismash"
                     /translation="RIVTIIQERQGEDFVVTESLSLKDDLDADSVDLMEFILTLEDEFS
                     IEISDEEIDQLQNVGDVVK"
     gene            complement(13636..14628)
                     /gene="plsX"
                     /locus_tag="A1M11_RS07225"
                     /old_locus_tag="ERS050419_01411"
     CDS             complement(13636..14628)
                     /EC_number="2.3.1.274"
                     /GO_function="GO:0043811 - phosphate:acyl-[acyl carrier
                     protein] acyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0008610 - lipid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="plsX"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000717456.1"
                     /locus_tag="A1M11_RS07225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS050419_01411"
                     /product="phosphate acyltransferase PlsX"
                     /protein_id="WP_000717462.1"
                     /transl_table=11
                     /translation="MKKIAVDAMGGDYAPQAIVEGVNQALSDFSDIEVQLYGDEAKIKQ
                     YLTATERVSIIHTDEKIDSDDEPTRAIRNKKNASMVLAAKAVKDGEADAVLSAGNTGAL
                     LAAGFFIVGRIKNIDRPGLMSTLPTVDGKGFDMLDLGANAENTAQHLHQYAVLGSFYAK
                     NVRGIAQPRVGLLNNGTESSKGDPLRKETYELLVADESLNFIGNVEARDLMNGVADVVV
                     ADGFTGNAVLKSIEGTAMGIMGLLKTAITGGGLRAKLGALLLKDSLRGLKKQLNYSDVG
                     GAVLFGVKAPVVKTHGSSDAKAVYSTIRQIRTMLETDVVAQTAREFSGE"
     gene            complement(14625..15395)
                     /gene="recO"
                     /locus_tag="A1M11_RS07230"
                     /old_locus_tag="ERS050419_01412"
     CDS             complement(14625..15395)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006281 - DNA repair [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /codon_start=1
                     /gene="recO"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000616164.1"
                     /locus_tag="A1M11_RS07230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS050419_01412"
                     /product="DNA repair protein RecO"
                     /protein_id="WP_000616167.1"
                     /transl_table=11
                     /translation="MIQSITSQGLVLYNRNFREDDKLVKIFTEQVGKRMFFVKHAGQSK
                     LAPVIQPLVLARFLLRINDDGLSYIEDYHEVMTFPKINSDLFVMAYATYVAALADASLQ
                     DNQQDAPLFAFLQKTLELMEAGLDYQVLTNIFEIQNLTRFGISLNFNECVFCHRVGQAF
                     DFSFKYGACLCPEHYHEDKRRCHLNPNIPYLLNQFQAIDFETLETISLKPGIKQELRQF
                     MDQLYEEYVGIHLKSKKFIDSLADWGQLLKEEKK"
     gene            complement(15392..16561)
                     /locus_tag="A1M11_RS07235"
                     /old_locus_tag="ERS050419_01413"
     CDS             complement(15392..16561)
                     /EC_number="2.6.1.-"
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_function="GO:0030170 - pyridoxal phosphate binding
                     [Evidence IEA]"
                     /GO_process="GO:0009058 - biosynthetic process [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Aminotran_1_2 (31-382). E-value:
                     3.9e-64. Score: 209.0. Matches aSDomain:
                     nrpspksdomains_A1M11_RS07235_Aminotran_1_2.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_1_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_5"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DegT_DnrJ_EryC1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1019: aminotransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007519430.1"
                     /locus_tag="A1M11_RS07235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS050419_01413"
                     /product="pyridoxal phosphate-dependent aminotransferase"
                     /protein_id="WP_000366342.1"
                     /sec_met_domain="Aminotran_1_2 (E-value: 3.9e-64, bitscore:
                     209.2, seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Aminotran_5 (E-value: 7.5e-09, bitscore:
                     27.0, seeds: 34, tool: rule-based-clusters)"
                     /sec_met_domain="DegT_DnrJ_EryC1 (E-value: 5.9e-09,
                     bitscore: 27.7, seeds: 38, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDLTKRFNKQLDKIQVSLIRQFDQAISEIPGVLRLTLGEPDFTTP
                     DHVKEAAKRAIDQNQSYYTGMSGLLTLRQAASDFVKEKYQLDYAPENEILVTIGATEAL
                     SATLTAILEEGDKVLLPAPAYPGYEPIVNLVGAEIVEIDTTENGFVLTPEMLEKAILEQ
                     GDKLKAVILNYPANPTGITYSREQLEALAAVLRKYEIFVVCDEVYSELTYTGEAHVSLG
                     TMLRDQAIIINGLSKSHAMTGWRLGLIFAPAAFTAQLIKSHQYLVTAANTMAQHAAVEA
                     LTAGKNDAEPMKKEYIQRRDYIIEKMTALGFEIIKPDGAFYIFAKIPAGYNQDSFAFLK
                     DFAQKKAVAFIPGAAFGRYGEGYVRLSYAASMETIKEAMKRLEEYMREA"
     aSDomain        complement(15416..16468)
                     /aSDomain="Aminotran_1_2"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_A1M11_RS07235_Aminotran_1_2.1"
                     /evalue="3.90E-64"
                     /label="A1M11_RS07235_Aminotran_1_2.1"
                     /locus_tag="A1M11_RS07235"
                     /protein_end="382"
                     /protein_start="31"
                     /score="209.0"
                     /tool="antismash"
                     /translation="VLRLTLGEPDFTTPDHVKEAAKRAIDQNQSYYTGMSGLLTLRQAA
                     SDFVKEKYQLDYAPENEILVTIGATEALSATLTAILEEGDKVLLPAPAYPGYEPIVNLV
                     GAEIVEIDTTENGFVLTPEMLEKAILEQGDKLKAVILNYPANPTGITYSREQLEALAAV
                     LRKYEIFVVCDEVYSELTYTGEAHVSLGTMLRDQAIIINGLSKSHAMTGWRLGLIFAPA
                     AFTAQLIKSHQYLVTAANTMAQHAAVEALTAGKNDAEPMKKEYIQRRDYIIEKMTALGF
                     EIIKPDGAFYIFAKIPAGYNQDSFAFLKDFAQKKAVAFIPGAAFGRYGEGYVRLSYAAS
                     METIKEAMKRL"
     gene            16710..17720
                     /locus_tag="A1M11_RS07240"
                     /old_locus_tag="ERS050419_01414"
     CDS             16710..17720
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397796.1"
                     /locus_tag="A1M11_RS07240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS050419_01414"
                     /product="YeiH family protein"
                     /protein_id="WP_050079636.1"
                     /transl_table=11
                     /translation="MSFLSKNGAGILVCLLISILSWYLGGFFPVIGAPVFAIFMGMLLH
                     PFLSSYKQLDVGLTFSSKKLLQYAVILLGFGLNISQVFAVGQSSLPVILSTISIALIVA
                     YLFQRFFALDTKLATLIGVGSSICGGSAIAATAPVIHAKEKEVAQAISVIFFFNVLAAL
                     IFPTLGTWLHLSNDGFALFAGTAVNDTSSVTATASAWDSLYQTNTLESATIVKLTRTLA
                     IIPITLFLSYWQSREQKNKQGLQLKKVFPLFILHFILASLLTTLLTSLGVSSSFFTPLK
                     QLSKFLIIMAMSAIGLKTNLVAMVKSSGKSIVLGAVCWIAIILTSLGMQTLIGIF"
ORIGIN
        1 tatggtcagc ttggcttgct tcaaactgag caaaattttt cttaatcaag tcaaaatcaa
       61 tctctgcaga gagggcttga cctgggatgt agtagatatt ttccccaaca gctttaaatt
      121 ctggagagag caccttacgg ctatctgccg tcgtcacccc aaaggcaacc aaggttggcg
      181 gaacggtcaa ttcttcaaag gtaccagaca tggagtcctt accaccgata gatggcaagc
      241 caagttgaat ctgagcttca atagagccta gaagggcggc tactggctga ccaaaacgct
      301 ctgcttgctt gtccatccgc tcgaaatatt cttggtaaga gaaacgagcc ttagaccagt
      361 tggcaccagc agccaccaaa cgagcagttg cttcgataac cgcgtaagca gcaccgtggt
      421 atggagacca ttcagctaca tatgggttga aaccttgagc aatgaccgac gcagtatgag
      481 tcacaccgtg ttgaactggc aatttctgca cagatgcctc agttggtgtg agttggtaac
      541 gaccaccaag tgggtgatta accgttgagc gtccaacaga gcagtcaaag acagtctgta
      601 atcctttttg acttgcatgg ttgaggtcag atagaaccgt aagggtatct gattccagtg
      661 tttcagcaga tgtttgacgc tcttctggga gtttgacatc cttgtccaca actttggcat
      721 cgacaaccac gcgcacacca ttggtgtcaa ggaaacgacg ctccaagtca acgattgtct
      781 caccattcca gtgcatgaca agatttggtt tttcagttac tgtcgccacc acaacagcat
      841 caatattttc tttgttacat tcggcaacga aggcatccac atcttcagga tgaaccacga
      901 ccgccatccg ttcttgtgat tcagagatgg caatttctgt accattcaag ccctggtatt
      961 taagaggcac cttgttgagg tcgatttcaa gaccgtctgc caattcaccg atagccacac
     1021 agacgccgcc tgccccaaag tcattggact tcttgatcag acgagtgaca ttgccattac
     1081 ggaagaggcg ctgaatcttg cgttcttcga tggcatttcc tttttgaacc tcagcaccag
     1141 cagtctctac agactcaact gtttgaacct tagaagagcc cgtcgcacca ccgacaccat
     1201 cacgacctgt tttgcctccg agaaggatga tcacatcacc tgcttcaggt ttttcacgga
     1261 caacattgcc cttgggagcc gcaccaacaa cggcaccaag ttccatacgt ttagctacaa
     1321 agcctgggtg gaagtattca cgaacgtagg ttgtggcaag cccaatctgg ttaccatatg
     1381 aagaataacc atgagctgct gttttagaaa tgacttgttg tggcaatttc ccagcgcgag
     1441 tttccgaaat cggtgctgta atatcaccag cacctgaaat acgcatggct tggtaaacat
     1501 aggaacggcc tgacaacgga tcacgaatag ctccaccaat acaggtagcc gctccaccaa
     1561 atggctcaat ttctgttgga tggttgtggg tttcgttttt aaacatgagg agccaaggtt
     1621 ccttgacacc atcaacgtcc acttcaattt caactgagca ggcattgatt tcgtcagaga
     1681 cttccatatc atccaatcgt ccattagcac gctcataacg accgaaaata gtcgccatat
     1741 ccatcaaggt ttgtggtttt tcagaccgac ctaattcctc gcgcatggca atatacttgt
     1801 cataggttga ctgcaattgc ttttgaaatt tagaagctga aaagtcgatg tgtttcaact
     1861 ctgtctcaaa agtcgtatga cggcagtggt cagaccagta agtgtccaaa accttaagtt
     1921 cagtctcagt tggcacgcgc ccgattgact taaagtagtc ttggataaag agcaaatcat
     1981 ccacttccat ggccatccct tgttcggcct tgtagcgagc aaaatcttct gctgtatagc
     2041 tttcaaagaa agtcaatttt ggaatggtct tgtctgactc tgaaaactcc tgcttggcaa
     2101 tccctatcgt gatatccttg aaacgagaat caactggatt gagcaggtag tttttgacag
     2161 ctttcaactc agtcgcatca atatctttat tcaccaagta aagttgggct gtgttgactg
     2221 tcacgtcact cgaacttccc aacaaaagca aggcttcctg tgacgaagct gcacgctggt
     2281 caaactgccc tggcagactt tcaatggcaa agaaagcata gttagcaaga tccgcctgca
     2341 cagatacttc atctaaaaca tggtcggtta cctgctcaga gaaaatgtgc ttctctgcag
     2401 gtgcaaacaa gtcctcagcc aagtcaaata catcatatac ttgcacaata cgaatacttt
     2461 tcaagcttga cagtcccaag ttgtgctgga gctctctaac caaactctct gacttgacct
     2521 gaaaatcagc ctttttttca acaaaaatac gtttatccat caattcttat tcctttattt
     2581 cagctcttgc aatattccca aacagccttg aggttgttat tttaaaccct gcaacttttc
     2641 ctagacaatt tcgtaaacat cggttagttc acctagttct ctacagagtg aaaaggtctg
     2701 ggggaccttt tcagcctgag tccttttagt tgagagacga aggttttcca ttgcaaacag
     2761 attatttcaa ttcctgcaac ttttcccaaa caatctcata aacgtcggtt agttctccca
     2821 atcctctacg gaaaacatcc ttatccatgt ggttgccatc agcatcccac aagcggcagt
     2881 tatctggtga aaattcgtct gccaagataa tcttgccatc cttgtcaaaa ccgaactcta
     2941 gcttaaagtc aatcaattta agcccaatct cagcaaacca gactttcaat agttcattga
     3001 tacgacgcgt ttcttccttc aagtaggcaa tctgctggtc atccgcaatc tgtaggaatt
     3061 tcacatgctc atcattgata aatggatcat ccaaatcatc atttttgtag taaaattcga
     3121 caatcggagt ctccaaggcg attccctcat ccacaccaaa acgttttgaa aaggaaccag
     3181 cagtatagtt gcggagcacg acttccaaag gaataatctt aaccttttta ttgagttgtt
     3241 ccgtgtctga aagtttctcc acaaagtgag tcgccacacc agccgcattt aatttctcaa
     3301 aaataaaaga tgagatctga ttattcaaga ctcccttacc tgcaatctgc tccttcttga
     3361 caccattgaa agcagtcgcc tggtccttgt aagttgaaat aataagattt tcatcctcag
     3421 ttgtatagat atctttagct tttcccgaat agatcaattg ttttgacatt ttaaagttcg
     3481 cctttcgtat tacttgagca cattttacca caaaaaacca aaaaacacaa gaatttaacc
     3541 gaataaatag tagatgtttt tcaaaaattg taaagaaaaa actgcaagaa gaatctttct
     3601 cacagtttaa aaattattta actctaaaaa cacgaacatt actctttgtt caaaaattga
     3661 tccaaataat aacgtagata acttttcttg cccgtaatca tctgcaagcg gccttccacc
     3721 ccgtacctaa gtttttcagc ctgctccgaa gttagattag tctccgcctc gattttaaag
     3781 aaattccctt tctcagtctt agtagctgtc gcatcaatac ttgtaatagt agaatctagg
     3841 aaaagttgat tcccggcatc atgagtcgta gtatagcgaa cagaatcacc gaccttgatt
     3901 cttgctacat cttttgaact tagataggct gtgagtttgg ctttcccttc tctttccaaa
     3961 gatggataaa gttgggctag tagggcacct tctgcaacca tgctagaatc actggtctca
     4021 ggattaagat gaagcacccc atcctcactc gccgtaattt tccccttgtc taaaagattt
     4081 ccctgtacct tcttacctga ctctgcctcc aagattttct gggctagaag ggtcaattcc
     4141 tgaccaacct ttgccaaatg ttgggattta agggattcca attgactgct taaccctgac
     4201 gcataggctt gctgggtacc tgaacctgca tactggacac ggtaagtagc aagactagat
     4261 tctaactgag aaatctgtgc ttcaacctgt gcaactgcct gaaccttaat ttggggattt
     4321 tcttcgccct gagacttgta ggactggtaa agagagtagg ctagattctg accggccaag
     4381 gaagcacctg tttcaatagc tgacttagct gtctggtaat cgcgaatttt agcctctgtt
     4441 tgactgatga ggttgccgat ttcggcttgg gtttggctag ctgctgcatt ctgggacgcg
     4501 atggtctcat tttgttgcga tgtactagcc ctaagactgc ctgcttgact gatgtagtcg
     4561 cgaaaggtgg cttggtagcc aaacttatcc tcctctggaa agtggttctc cccttcttgc
     4621 aggctctttt gcagatactc caattgcttt ttttgatcct ttagcatgtc caactgactg
     4681 gcataggact ccgcttggac accctctgcc ccttcttggt attgaaccaa aagatccccc
     4741 ttcttaacca gcttattttc ttccaaatga ttgacaagaa tacgattgtt gctagttgac
     4801 tggatatttg caaggatacg actgggttcg acagtagctc tagtggacaa actcatctcc
     4861 ttctctgcaa cagttgcaaa gccaagtaaa aacacgagca gaagggccat gggtacaatc
     4921 acactactgg aaaaattatg gtaacgacga ttataaaact ccgcactttc taaaaattct
     4981 ggtttcatcc tctcctcttt ctagctattg accaaatggg cgtaaaagcc accctgtgca
     5041 agcaaatcag catgctttcc ttcttcgaca atcttgccct gatccaagac aaccaccttc
     5101 tctgtccgct cagcaatagt caagcggtga gcaatgaaaa tcaaggtctt gtccaaagcc
     5161 atgagattat cgacaatccg cttctctgtc aaaatatcca aactgctagt cgcctcatcc
     5221 aaaatcaaga ccggcgcatc tgtcaagaga gcacgcgcca aagcgattct ctgacgttga
     5281 ccacctgaaa tccctgcccc atctgaagtc aattctgtct ggtaattcag tggcatgcgc
     5341 tcgatatcct ctcgaatctc taccaattcg accgcccgta agatatcttc ctgtgtcgtc
     5401 ccctccttgg ctcccaaaag aagattctcc aaaatcgttc cgttaaagac atagggctgt
     5461 tgaggcagat agttgatgta ctggcgcagg gcttttttat caatctgatt gagattgaca
     5521 ccacccagac taatctcccc ttgacttggg tcataaaaat taaccatcat cttggccaaa
     5581 gtcgtcttac ctgaccctga aatccccaca aaagccacct tagacccttg gggaacggtt
     5641 aaattgatat ccgacaagac gtctcgacca tagccatact tgtaatgaac ctgcttgaag
     5701 gtcatatctc ccttcatcaa gctcaaatcc tcaactgttt tcttctcctc aaactcagaa
     5761 gctactagat acacttcatt tagacggtta ttggcaacct gcgctgtctg aagcttggtt
     5821 tgcagattga tgatattttc caaaggattg gtaaagtaaa ccagcaaggt attataggta
     5881 atcaactgcc ccaaactcat cttgccatcc atgaccagaa cagcccccat ccagagaatg
     5941 ccgacattaa gcaagagatg ggcaaccttt ttcagagcct tttgctgact ctctgctcga
     6001 ctataggtaa aggatttctt cagataatcc acaaattcct tgtcaatttt ttggtaacgc
     6061 tgactttcac tggtcaagga cttgatagtc tcaataccgt tgatgtcctc aatgatagaa
     6121 gaagacagaa ccgcattggc ttccatggta tcccgattca tcttttcaaa cggcttcata
     6181 aaggcaaaga taatcactgt gtagatagga agcgccaata aagtcatgaa aaagagattg
     6241 gtattttgtg aaaatagaac aagggaaata atgacaaccg ttgacacatc taggaaaatc
     6301 gaaaggatgg tcgaagccag cgcatcgatg atactgttag catctgtaaa acgagacacg
     6361 atctcccctg tcctgcgtgt cgcaaagaag gacataggga ggtgaaaaac atgcttgata
     6421 taggacaaaa tcacgtcaat cgacaagcgt tgccccaaaa caagcaagag atactcctga
     6481 gcgtaagaca agatttgctg gaggatgtag acgatgacta gcccaataga aataatccct
     6541 agtgtcgaac gcatctgatc tggcacatag gtatcaatga tagactgcag ataataagaa
     6601 cccacaatgt taatcacggt taccaagagt gttgccaaaa cgatattggc aatcaagcca
     6661 cgctgcttca ctaatatagg gataaaagag agcagaccat ttttttgttc cttatgaggc
     6721 ttatagtctg gactaggtgc cataaaaaga gtcactcctg tccattcttc ctcaaaacgc
     6781 tcacgtggca gtttagtcaa cttcaccccg ggatctggat cggcaatatg aatgctatcc
     6841 ttatcctgcc cagtcaccac atagtagtgg agcaatttcc cttccttaag cacatgggca
     6901 acaaaaggaa aagtcaaatc cggcaagtca aaaagcgtca tatccgcctt aatggctcgc
     6961 gtctcaaaac caatctcctc tgccaccttg accaagccca aagccgtcgt cccatccatg
     7021 gtcgtcttag ccaattctcg caagtgagcc aaaaaataat aactaccata gtagccaaaa
     7081 accatggcta atgaagctac accgcagtcc atctgatcca cttgcggacg atagtgacgt
     7141 ttcccaaatt tcatattcat ctccttttcc ctaatactca atgaaaatca aagagcaaac
     7201 taggaaacta gccgcaggct gctcaaaaca ctgttttgag gttgtagata ggactgacga
     7261 agtcagtcac ctatatacgg caaggcgacg ttgacgtggt ttgaatttga ttttcgaaga
     7321 gtataaactc atctgataac aactatctta ccccaatcac taaacaaaaa ctggacttcc
     7381 ttcccaaatg agcctatctc cctcccaact gcactttttg gataaaaaaa taggcagaac
     7441 aaacgttcta cctagaaaat ataagaatta caagttaaca aaaccgaaat gatttcatat
     7501 cattattaag taaagaaaaa aattttagta tttctaaaaa ctatttataa tagacattat
     7561 agcattaaat aaaaatggta cagaaaacac tactgtcaat cttaaatttt taaatctcgc
     7621 ataatttgtt atcccaatta gtaatactgt caatacgctg aaataggcaa actttatatc
     7681 cgatggatta aataaataac aaagtaaaat gctaaaactt aaggttatat ttttagataa
     7741 aagaatatct ccaaagttcc tcttattctt atcaaaaaat aatgtaatca gaaagagaga
     7801 aaatccatat tcaataagag ttgctataaa tgtgaaaaca acagaaatca ctgtcaatat
     7861 tgtttctatt ttaattgtaa aaagattaga tagttcagat aatttatcaa tttgttcatc
     7921 taaaattccc gacttcatca gtaaatcaat aaacaaatat aaaagaaaaa gataaataat
     7981 cagattcatt aatttgtata aactattatt tgtttgaaat ttcataaacc cgtccttcct
     8041 ctattaaaat cctttgagat ttgctaatca attcttgatt caataaatta tgagatacat
     8101 atataatagt agagctttct ttcatggaaa ttaagcgttt agcaatcata tcaatacttc
     8161 ttgcatccac tgttgataaa gtctcatcaa taaaaatata atcccaattt ttagcaaaaa
     8221 ttaaggataa gcctaatttg aattttgttc cagtagatgc tgtcatatag ttatctccga
     8281 ttttattatc aaaaaaagta ttaatttgtt ctttatcctc aaatgataga tggatttgaa
     8341 aagaatcaca caacaactgc aaattttctt ctatagtaaa tggaacaacc ccaagctgat
     8401 tggtatcaag gtatagtaca tctttggaga cacaattctt taaaccacta tcaaaagtct
     8461 ctagcccagc taaaagttgt agaagggtgc tctttcctga accattctct ccttcaactc
     8521 tgtaaattcc cttatcaatc tctagtgata tatttttcaa tatacattta tcataacttt
     8581 tagattcatt ttcaattttc ataatttaat tccctctatc aacgctgcta aaattaataa
     8641 aagataagaa atgatatacc attttaaatt actttttata taaataagta tatttttaat
     8701 tcccctatcc ttcaataatc ggtataaaag atactgactc ataccttgat accaaataaa
     8761 attcggtatt tcaataagag catgaggtaa tattcctttt attgtagcta ctattccaat
     8821 catctgacca gatataccca attgtattcc taaagatagc aaatcaaaaa gttgcaataa
     8881 gggcgaaatc ggaaaacaga atagatatag caaaaaattt gtagaatttg cctgtaaaac
     8941 tgtcaatgta aattgtaatt ccagtttcgg aggtatagta gcaaaagtct cattttttaa
     9001 tataaagctt aaaagtaaac ctagtaaaaa acagactata caaaataaca catagtaaat
     9061 cagaaaacca ctttttctca tctaatgccc cctactaaaa ttacaaatat tatcagaaaa
     9121 caatataaaa ccagaaaact ccatctcaat aaactaactg tacctttaat taaaaataga
     9181 gctttcttat aatagacata ggctataaaa taattgaatg gaatcaataa caaattcaac
     9241 aaaatacttt ttatatcatt actataactt gtcaccggaa tcaaacataa caacaatgaa
     9301 aattgtaaga aagagattaa atgcgtcaac atcattagtt gtgcattctt aaaaaagaaa
     9361 ttcattttag aatgattaag agcagataat tgaagtaaag ctagatctac cccaattgag
     9421 gatttatgat tccctattat tgcctccatt aatgtaatat atattgaggt ataaagaaat
     9481 aatattggta tttttgtgtc atcaattgat aacatcgtca tcatatacca aaatagatag
     9541 gaaagaagaa tactaatcaa aataaaagaa aaagttaacc ctttatttaa ccaacaaaaa
     9601 cgaagcaata taaatagact gctacgaaat cttttttgac tcattcgact gcttttaaaa
     9661 tagaaattac tcgcatgatt atctaatatc cccatgacta aaataaaata attgagtagt
     9721 atgacataaa ttacaacttg tccttgttct atagacaata gtcctataga taaaaataag
     9781 aacaatttac ttataattga aaacaaacta ggtagaatta aagaaataat ttgaatagct
     9841 atcaaacaaa gagtaatgga taaataaaaa tatccaataa tatctagaaa atacaaaata
     9901 aataaataaa tgaatgattg taaaatttgg aaagaataat atttcttgac aatggcaaga
     9961 agatagagaa aaatatagtt tttccttata tagaaagtat ttattttttt actttggata
    10021 ggcagtttca tattataacg attcaaagta gcgtaatcta ctaccaaaaa aagtaaaaat
    10081 aatttccctt gaaaaggaag atagctttta aaatagattg acaaacttat gataacaaaa
    10141 aacaaaaggg ttatcccaat aaaattaaga taacctaaaa tactttcaca ttctttttta
    10201 gaaagtattt tcatctagtt ctaccataga gctgctttag cagcaccttt ctttttcaat
    10261 agacttgttc ggtaactgta ctataagcac taatcaaatt gactacagta gcagcagctt
    10321 ttgtcgaaat tcctaatgtc ccagccaaca taggaaaaga aacaacacct aagcttaacc
    10381 aactaatgac tgctaacatt gctgaaacaa taagaaattt attatgaaat tccattcttt
    10441 tagatttcat tttagtgtac tccttttgta tattatgtat gttttattga gagttaattc
    10501 gcacatgttg tattcctaac tctcttcaaa tgttcgtcta tattttatac tacttttatt
    10561 aacatatcta taataaataa attactacta cattttccta gattatcaaa ttacttttat
    10621 atcactaaga ctcaataaaa gataatgtct atttaacttt tatacgatta ctacctcttt
    10681 tttagtttac acttcctaca tcataaataa acatactcaa ccctcacaat ctccaaataa
    10741 ctcttctata tcattgaaaa ttgagtttca tcctctatac taatgtagga cattccttta
    10801 atccaatata agaatacctt gttccattaa tctctacccg atattataga tagaaccaaa
    10861 ttcctatact taaaaggaca aataacgttc caaccataat aaacctcctt tctttttgag
    10921 aacgttttct ttataggttt agtatagcaa aaacatgaaa aaaacaacat gacttagaag
    10981 tcaggttgtt gggaaatcta tctgtttttc tgctaaaatt ctctgaacta atacctgatc
    11041 gtctagcaat tctgctagag aaatcgcctt ttcatagaaa ctttctgcct ctaaaatatt
    11101 cttgtctaca aataaagcat attttgcctt tagcaaaaat agatgaggtc ggtaaaaaac
    11161 atgtcttgtt ttagcaataa ttttctcaaa tgtttgaata tatatcagac tatcttctgt
    11221 ctgaatttgg ataaataggc tcagaagaac tttttccatt tgaactaggc tagccttatc
    11281 ttcatattct gaacatagca atactttttg agctaactcc tcaaaatgtt ctttatcttc
    11341 taatcccata gcacaacaaa agaaatacaa ttcaataatc aacaaatcat ttacagaaaa
    11401 atatttcttt tttaataact gctggaaata ttcttccact aaccctaaac cgtaggtcac
    11461 atctgaacta ccataaatat caaaacgagc ttgtgtcaca tccacaatta actgctcttc
    11521 ctcaggcaaa ttctcataat agttttcata tatttcctca agtatagctt cttttcgttc
    11581 gattcttccc ttatcagcgt aggtttgaga atgaatcagc tcatctttga gttttaggaa
    11641 tccttttgga atctctataa ccttaacatc cacaatattc tgtaatgata ctccaagttt
    11701 atccgcaatc aataataatt taggaagtgt tgctaaagct tgcccatttt caatacgtgc
    11761 tagctgacga atcgtcaact ctgattcatc accacaaata tctatctgag tttttccaca
    11821 agatcgccta atagttttga ttttataacc aatttcacgt ttcaactcat ccatagtaat
    11881 actccttaag ttgattacaa agatttcttt ttcttcctaa ttcttttgtc aatcatatat
    11941 aaaacgataa gcgaaaacag cggtagaaca atataactct tttcactcat tatcagctga
    12001 aatcccaggg ttgctagtat cttaaagatg aaaatattca tcaaaaatag aaaaacaaat
    12061 actaaaaaat attttaaaac cttcttcatt tcttttcttc aactttccta atttctacac
    12121 ctattttatc gaaaatatat ataaaactcc aaataaacac ttcgactgca ctttttttgg
    12181 caaaaaatag acagaacaaa catcctacct actaaaaata tgatatgaaa ggaaaatgat
    12241 tttttactga caccctaggc aagcttggga caaataaatc attgatagca acatttacga
    12301 catcctattt aaagttcctt caatttctaa tgtccccgct atttctaagc cacctctggt
    12361 atgatctatt cctagtcaga atagataaca ccgttctaaa ttacgattca tagttactcc
    12421 ttttttgact cgttactata agactcctat ttacatgcgc aaaataattt tgattcagat
    12481 tcatcattta tagttttgat tattttttaa cagatttttc tgttttcttc tccgaagact
    12541 ttaaaaattt ttttctaatt aaatcatcca tataaggacc aaatatacca actactaaac
    12601 caataataaa acttttaaaa tccataatta ccaccaacat gtcgctgcat aggccacacc
    12661 tccaagtata gctcctccca cagcaccagt tgctgcacct tgccatgttc ttgttttaat
    12721 tcctagctga agacctcgtg ctgctcctcc tccaacacct gctttggcaa aatctcccca
    12781 attgcatccg ccaccttcaa cgcaagcaag catctcagta tccataattt caaattgtga
    12841 catcgttttt gtattcataa cgaatacctc ttttttattt ttaatatttg tcttgttaca
    12901 aacttgacaa gtttagtata acagtatcta ttaatttttt tcatccaaat cttgaattgg
    12961 catcgaaacg tcttgaatta gcttttttgt ttcaaaatca tctctatttt taaaaaagat
    13021 gttttctaat cactttttta ctattagact tcctgcaaaa ctagaatcct agttcatgat
    13081 tgataatacc agcaatcaaa ttcattcgta atccgaagcg tttacgatga tttcgatagg
    13141 ttgttgaaaa cattttaaac gtttttactt tggcaaagat attctcaacc ttgcttctct
    13201 ccttagatag cgcatgatta caggctttat cttcaactgt tagcggcttg agtttgctgg
    13261 atttacgtgg agtttgtgct tgaggatata tcttcatgag tccttaataa ccactgtcag
    13321 ccaagatttt tccagcttgt ccgatatttc tcatttctaa aaaccatcta cttccgttga
    13381 cttggaactc cgattgctat tttccttgaa tgattttaac cacatctcct acgttttgga
    13441 gttggtcaat ttcttcatcg ctgatttcga tactaaattc atcttccaga gtcaagataa
    13501 actccatcaa gtcaacagaa tccgcatcca aatcgtcttt cagactcaag gattctgtca
    13561 cgacaaagtc ctctccctgt cgctcttgga taatggtcac aatacggtca aaaatttctt
    13621 tttctgtcat ctcttttatt ctcctgaaaa ttcacgcgca gtctgggcaa ctacgtctgt
    13681 ttctagcatg gtacgaatct ggcgaatcgt actataaaca gccttggcat cgcttgagcc
    13741 atgagtcttg acaacaggtg ccttaacacc aaacaagacc gctccaccaa catctgaata
    13801 attgagctgt tttttcaaac ctctgaggct gtccttgaga aggagggcac ctagtttcgc
    13861 tcgaagacca ccacctgtaa tagctgtctt gagcaagccc atgattccca tagctgtccc
    13921 ttcgatggat ttgagcacag cgtttcccgt gaaaccatct gccacaacaa catctgcaac
    13981 gccattcatc aaatcacgcg cttccacatt tccgataaag ttcaaacttt catcagccac
    14041 tagtaattca taagtttcct tacgaagcgg atcgcccttg ctactctctg ttccgttatt
    14101 gagcaagcca acacgtggtt gcgcaatgcc acgaacattt ttagcataga aggatcctag
    14161 aaccgcgtat tgatggaggt gctgggctgt attttccgca ttggcaccga ggtctagcat
    14221 gtcaaatccc ttcccatcta cagtcggcaa agtcgacata agcccaggac ggtcgatatt
    14281 cttgatacga cccacgatga agaatccagc agccaacaag gcacctgtat tcccagccga
    14341 aaggacagcg tctgcttcac catctttgac agccttggct gccaatacca tactggcatt
    14401 tttcttattc ctaatagctc tcgtaggttc atcatccgaa tcaatcttct catccgtatg
    14461 gataatgctg acgcgctctg tcgctgtcag atattgcttg attttagctt catctccgta
    14521 aagttgaacc tcgatatctg aaaagtcaga tagggcttga ttgacaccct caacaatggc
    14581 ctgaggtgcg taatcgcccc ccatggcatc tactgcgatt tttttcattt cttttcctct
    14641 tttagtaatt gtccccagtc tgctagggaa tcaataaatt tctttgattt taggtgaatc
    14701 ccaacgtact cttcatatag ttgatccata aattggcgta gctcttgctt gattccaggc
    14761 ttgagcgaaa tggtctccaa agtctcaaaa tcaatagctt gaaattgatt gagcagatag
    14821 gggatattgg gattgagatg acaacgtctc ttatcctcat gataatgctc tggacagagg
    14881 caggctccat atttgaaaga aaagtcaaaa gcctgaccaa cccgatggca gaagacacac
    14941 tcattaaaat tgaggctgat tccaaatcga gtcaaatttt gaatttcaaa aatattggtc
    15001 aaaacctgat aatccaagcc tgcttccatc aactccaaag tcttttgcaa aaaagcaaac
    15061 aagggagcat cctgctgatt gtcctgcaaa ctagcatctg caagagctgc cacataggtc
    15121 gcataggcca tgacaaagag gtcactatta atcttgggaa aagtcatgac ctcatgatag
    15181 tcttcgatgt aactgagtcc gtcatcattg attcgcaaga gaaatcgtgc cagcaccaag
    15241 ggctgaataa caggcgccag cttagactga ccagcgtgtt tgacaaaaaa catgcgtttg
    15301 ccaacctgct ctgtaaaaat tttgacgagc ttgtcatcct cacgaaaatt gcgattgtaa
    15361 agcaccaagc cttgactcgt gatagactga atcatgcttc tctcatgtac tcctcaagtc
    15421 gtttcatggc ttctttgata gtctccatgc tggctgcata agataggcgg acgtagcctt
    15481 ccccgtaacg tccaaaggct gcaccaggga taaaggcaac ggccttcttc tgagcaaaat
    15541 ccttcagaaa agcaaaggag tcttgattgt agcccgctgg aattttagca aaaatataga
    15601 aggcaccgtc tggtttgata atctcaaaac caagagcagt cattttttcg atgatatagt
    15661 cccgacgctg gatatattcc ttcttcatgg gctccgcatc atttttacca gccgtcaagg
    15721 cttctaccgc agcatgttgc gccatggtat ttgcggcagt gaccaagtat tggtgactct
    15781 tgattaactg ggctgtgaag gctgcaggag cgaaaatcag ccccaaacgc caacctgtca
    15841 tggcatgcga tttagacaaa ccattgataa taatagcctg gtctctcaac atcgttccta
    15901 gagacacatg ggcttcgcct gtgtaggtca attctgagta aacctcatca cagacaacaa
    15961 aaatttcgta cttgcgtaaa acagctgcca aggcctctaa ctgctctcga ctgtaggtaa
    16021 ttcctgtcgg attggctgga tagttgagaa taaccgcctt gagcttatca ccctgctcca
    16081 aaatggcctt ctccaacatc tcaggagtca agacaaaacc attttcagtc gtatcaatct
    16141 caacaatttc tgccccaact aagttaacaa tcggttcata gcctggataa gcaggagctg
    16201 gcaaaagtac cttgtctccc tcttccaaaa tagccgtcaa agtcgcagat aaagcctctg
    16261 tcgccccaat tgtaaccaag atttcatttt caggagcata gtccagttgg tacttttcct
    16321 taacaaagtc actagctgcc tgacgtagag tcagcagacc actcatccct gtatagtagg
    16381 attggttctg atcaatcgct cgcttggccg cctccttgac atggtctggc gttgtaaaat
    16441 caggttcccc caaggtcaaa cgcaagaccc caggaatctc cgaaatagcc tggtcaaact
    16501 gacgaatcaa cgaaacttga attttatcta actgtttatt aaagcgctta gttaagtcca
    16561 tagatacctc ctactttcaa aacgtatctc tattatacta caaaagcccc ccgaccgcaa
    16621 aaatacatta gagaatagct ttccactttc tattttactt ttcctcttta caggtctata
    16681 atggtaacag attctatttg gaggttttta tgtcatttct atcaaaaaat ggagcaggca
    16741 tcttggtctg ccttctcatt tccatcctat cttggtactt aggaggattc ttccctgtga
    16801 ttggcgcacc cgtttttgcg atttttatgg gcatgctcct acatcccttt ctctcgtctt
    16861 ataaacaact ggatgttgga ttgaccttta gttccaagaa attgctccag tatgccgtta
    16921 tcttgcttgg ttttggtctc aatatctctc aagtcttcgc agttgggcaa tcttcactcc
    16981 ctgtcatcct ttccaccatt tcaatagcct tgattgttgc ctacctcttc cagcgcttct
    17041 ttgccctgga tacaaaactg gctaccttga ttggagtagg ttcttctatc tgtgggggtt
    17101 ctgccattgc agcgacagcg cctgttatcc atgctaagga aaaggaagta gcccaagcca
    17161 tctccgttat ctttttcttc aatgtcttgg ctgcgctcat ctttccaacc ctcggcacct
    17221 ggcttcatct atccaatgac ggcttcgccc tctttgcagg aactgcggtc aatgatactt
    17281 cctctgtaac cgccacagct agcgcttggg acagtctcta ccagaccaat accctcgaat
    17341 ccgcaaccat tgtcaaactc acgcgcaccc tagctatcat ccccatcact ctctttctct
    17401 cctactggca aagtcgcgag caaaaaaata agcaaggctt acaactgaaa aaagtcttcc
    17461 cactttttat ccttcacttc atccttgcat cgctcctaac cacccttctg acctctctcg
    17521 gtgtgtctag tagtttcttt acccctctca aacaactctc taaattcctc attatcatgg
    17581 ccatgagtgc catcggtctc aaaactaatc tggtcgctat ggtcaaatcc agtggaaaat
    17641 ccattgttct cggagccgtc tgctggattg ccatcatcct caccagcctt ggtatgcaga
    17701 cccttatcgg cattttctaa tactcttcga aaatctcttc aaaccacgtc aacgtcgcct
    17761 tgccgtatat atgttactga cttcgtcagt tctatctaca acctcaaaac ggtgttttga
    17821 gctgacttcg tcagttctat ctgcaacctc aaaacagt
//
