LOCUS       NZ_FIXU01000005        21720 bp    DNA     linear   CON 15-DEC-2024
DEFINITION  Streptococcus pneumoniae strain B18210a, whole genome shotgun
            sequence.
ACCESSION   NZ_FIXU01000005
VERSION     NZ_FIXU01000005.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1
  CONSRTM   Pathogen Informatics
  TITLE     Direct Submission
  JOURNAL   Submitted (09-FEB-2016) SC, Wellcome Trust Sanger Institute, CB10
            1SA, United Kingdom
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_900052895.1-RS_2024_12_13
            Annotation Date                   :: 12/13/2024 02:58:16
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.9
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 2,298
            CDSs (total)                      :: 2,246
            Genes (coding)                    :: 2,088
            CDSs (with protein)               :: 2,088
            Genes (RNA)                       :: 52
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1, 1 (5S, 16S, 23S)
            tRNAs                             :: 46
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 158
            CDSs (without protein)            :: 158
            Pseudo Genes (ambiguous residues) :: 0 of 158
            Pseudo Genes (frameshifted)       :: 62 of 158
            Pseudo Genes (incomplete)         :: 91 of 158
            Pseudo Genes (internal stop)      :: 44 of 158
            Pseudo Genes (multiple problems)  :: 32 of 158
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 13:33:22
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 0
            Orig. end                         :: 21720
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            FIXU01000005.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..21720
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="T3PKS"
                     /region_number="1"
                     /rules="(Chal_sti_synt_C or Chal_sti_synt_N)"
                     /tool="antismash"
     gene            <1..101
                     /locus_tag="A1M11_RS12625"
                     /pseudo=""
     cand_cluster    1..21720
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(Chal_sti_synt_C or Chal_sti_synt_N)"
                     /kind="single"
                     /product="T3PKS"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21720
                     /aStool="rule-based-clusters"
                     /category="PKS"
                     /contig_edge="True"
                     /core_location="[547:1720](+)"
                     /cutoff="20000"
                     /detection_rule="(Chal_sti_synt_C or Chal_sti_synt_N)"
                     /neighbourhood="20000"
                     /product="T3PKS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      548..1720
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(Chal_sti_synt_C or Chal_sti_synt_N)"
                     /neighbourhood="20000"
                     /product="T3PKS"
                     /protocluster_number="1"
     CDS             <5..101
                     /codon_start=3
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001105201.1"
                     /locus_tag="A1M11_RS12625"
                     /note="incomplete; too short partial abutting assembly gap;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="IS5/IS1182 family transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="FKMFSTTYRNHRKRFGLRMNLIAGIINHELGF"
     gene            169..417
                     /locus_tag="A1M11_RS03135"
                     /old_locus_tag="ERS050419_00608"
     CDS             169..417
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001858369.1"
                     /locus_tag="A1M11_RS03135"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS050419_00608"
                     /product="hypothetical protein"
                     /protein_id="WP_001818278.1"
                     /transl_table=11
                     /translation="MVSSSGSEFQSGWQEHQLIAEKVSKTLDKTFDKDVREIPTSQFYQ
                     KFVDEMGRTYSGNLILQELITVNGAYKATYIGELSSN"
     gene            548..1720
                     /locus_tag="A1M11_RS03140"
                     /old_locus_tag="ERS050419_00609"
     CDS             548..1720
                     /EC_number="2.3.3.10"
                     /GO_function="GO:0004421 - hydroxymethylglutaryl-CoA
                     synthase activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) T3PKS:
                     Chal_sti_synt_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1043: hydroxymethylglutaryl-CoA synthase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004181031.1"
                     /locus_tag="A1M11_RS03140"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS050419_00609"
                     /product="hydroxymethylglutaryl-CoA synthase"
                     /protein_id="WP_000151962.1"
                     /sec_met_domain="Chal_sti_synt_N (E-value: 2.8e-09,
                     bitscore: 29.5, seeds: 21, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTIGIDKIGFATSQYVLKLQDLAEARGIDPEKLSKGLLLKELSIA
                     PLTEDIVTLAASASDSILTEQERQEVDMVIVATESGIDQSKAAAVFVHGLLGIQPFARS
                     FEIKEACYGATAALHYAKLHVENSPESKVLVIASDIAKYGIETPGEPTQGAGSVAMLIT
                     QNPRMMAFNNDNVAQTRDIMDFWRPNYSTTPYVNGVYSTQQYLDSLKTTWLEYQKRYQL
                     TLDDFAAVCFHLPYPKLALKGLKKIMDKSLPQEKKDLLQKHFDQSILYSQKVGNIYTGS
                     LFLGLLSLLENTDSLKAGDKIALYSYGSGAVAEFFSGELVEGYEAYLDKDRLNKLNQRT
                     VLSVADYEKVFFEEVNLDETNSAQFAGYENQDFALVEILDHQRRYSKVEK"
     gene            1720..2994
                     /locus_tag="A1M11_RS03145"
                     /old_locus_tag="ERS050419_00610"
     CDS             1720..2994
                     /EC_number="1.1.1.88"
                     /GO_function="GO:0004420 - hydroxymethylglutaryl-CoA
                     reductase (NADPH) activity [Evidence IEA]"
                     /GO_function="GO:0016616 - oxidoreductase activity, acting
                     on the CH-OH group of donors, NAD or NADP as acceptor
                     [Evidence IEA]"
                     /GO_process="GO:0015936 - coenzyme A metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1187: hydroxymethylglutaryl-CoA reductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000704367.1"
                     /locus_tag="A1M11_RS03145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS050419_00610"
                     /product="hydroxymethylglutaryl-CoA reductase, degradative"
                     /protein_id="WP_000704388.1"
                     /transl_table=11
                     /translation="MKISWNGFSKKSYQERLELLKAQALLSPERQASLEKDEQMSVTVA
                     DQLSENVVGTFSLPYSLVPEVLVNGQEYTVPYVTEEPSVVAAASYASKIIKRAGGFTAQ
                     VHQRQMIGQVALYQVANPKLAQEKIASKKAELLELANQAYPSIVKRGGGARDLHVEQIK
                     GEPDFLVVYIHVDTQEAMGANMLNTMLEALKPVLEELSQGQSLMGILSNYATDSLVTAS
                     CRIAFRYLSRQKDQGREIAEKIALASQFAQADPYRAATHNKGIFNGIDAILIATGNDWR
                     AIEAGAHAFASRDGRYQGLSCWTLDLEREELVGEMTLPMPVATKGGSIGLNPRVALSHD
                     LLGNPSARELAQIIVSIGLAQNFAALKALVSTGIQQGHMKLQAKSLALLAGASESEVAP
                     LVERLISDKTFNLETAQRYLENLRS"
     gene            complement(3029..3994)
                     /locus_tag="A1M11_RS03150"
                     /old_locus_tag="ERS050419_00611"
     CDS             complement(3029..3994)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1078: LacI family
                     transcription regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002929307.1"
                     /locus_tag="A1M11_RS03150"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS050419_00611"
                     /product="LacI family DNA-binding transcriptional
                     regulator"
                     /protein_id="WP_000225999.1"
                     /transl_table=11
                     /translation="MVAKLTDVAKLAGVSPTTVSRVINKKGYLSEKTIQKVNEAMRELG
                     YKPNNLARSLQGKSAKLIGLIFPNISNVFYAELIDKLEHQLFKNGYKTIICNSEHDSEK
                     EREYIEMLEANQVDGIISGSHNLGIEDYNRVTAPIISFDRNLSPDIPVVSSDNYAGGVL
                     AAQTLVKTGAQSIIMITGNDNSNSPTGLRHAGFASVLPKAPIINVSSDFSPVRKEMEIK
                     NILTREKPDAIFASDDLTAILIIKIAQELGISVPKELKVIGYDGTYFIENYYPQLATIK
                     QPLEEIACLTIDLLLQKIEGKEVATTGYFLPVTLLPGKSI"
     gene            complement(3975..5429)
                     /locus_tag="A1M11_RS03155"
                     /old_locus_tag="ERS050419_00612"
     CDS             complement(3975..5429)
                     /EC_number="3.2.1.26"
                     /GO_component="GO:0005737 - cytoplasm [Evidence IEA]"
                     /GO_function="GO:0004564 - beta-fructofuranosidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000455313.1"
                     /locus_tag="A1M11_RS03155"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS050419_00612"
                     /product="sucrose-6-phosphate hydrolase"
                     /protein_id="WP_050250726.1"
                     /transl_table=11
                     /translation="MEWTTERRYRLYQDWTQEEIQHIKENMAQSPWHTHYHVEPKTGLL
                     NDPNGFSYFDGKWILFYQNFPFGAAHGLKSWAQLESDDLIHFRETGVKVLPDTPLDSHG
                     AYSGSAMQFGDNLFLFYTGNVRDENWIRHPYQIGALMDKEGKITKIDKILIDQPADSTD
                     HFRDPQIFNFKGQYYAVVGGQNLEKKGFVRLYKAVNNDYTNWQAVGDLDFANDRTAYMM
                     ECPNLVFVEEQPVLLYCPQGLDKKVLDYDNIFPNMYKIGASFDPKNAKMVDVSQLQNMD
                     YGFEAYATQAFNAPDGRALAVSWLGLPDVSYPSDRFDHQGTFSLVKELTIKDDKLYQYP
                     VAAIKDLRASEEAFSNRSQTKNTYELELNLEANSQSEIVLLADKEGKGLSINFDLVNSQ
                     VTVDRSQAGEQYAQEFGTTRSCPIENQATTATIFIDNSVFEIFINKGEKVFSGRVFPHA
                     DQNGILIKSGNPTGTYYELDYGRKTN"
     misc_feature    complement(5506..5521)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: medium, score: 23.4"
                     /tool="antismash"
     misc_feature    5619..5633
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence:
                     medium, score: 21.76"
                     /tool="antismash"
     gene            5806..7689
                     /locus_tag="A1M11_RS03165"
                     /old_locus_tag="ERS050419_00613"
     CDS             5806..7689
                     /EC_number="2.7.1.211"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0008982 -
                     protein-N(PI)-phosphohistidine-sugar phosphotransferase
                     activity [Evidence IEA]"
                     /GO_process="GO:0009401 - phosphoenolpyruvate-dependent
                     sugar phosphotransferase system [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1145: Glucose-specific phosphotransferase enzyme IIA"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001864794.1"
                     /locus_tag="A1M11_RS03165"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS050419_00613"
                     /product="sucrose-specific PTS transporter subunit IIBC"
                     /protein_id="WP_001064554.1"
                     /transl_table=11
                     /translation="MNNQEIAKKVIDALGGRENVNSVAHCATRLRVMVKDEEKINKEVI
                     ENLEKVQGAFFNSGQYQIIFGTGTVNKMYDEVVVLGLPTSSKDDMKAEVAKQGNWFQRA
                     IRTFGDVFVPIIPVIVATGLFMGVRGLFNALEMPLPGDFATYTQILTDTAFIILPGLVV
                     WSTFRVFGGNPAVGIVLGMMLVSGSLPNAWAVAQGGEVTAMNFFGFIPVVGLQGSVLPA
                     FIIGVVGAKFEKAVRKVVPDVIDLLVTPFVTLLVMSILGLFVIGPVFHVVENYILIATK
                     AILSMPFGLGGFLIGGVHQLIVVSGVHHIFNLLEVQLLAADHANPFNAIITAAMTAQGA
                     ATVAVGVKTKNPKLKTLAFPAALSAFLGITEPAIFGVNLRFRKPFFLSLIAGAIGGGLA
                     SILGLAGTGNGITIIPGTMLYVGNGQLPQYLLMVAVSFALGFALTYMFGYEDEVDATAA
                     AKQAEVAEEKEEVAPAALQNETLVTPIVGDVVALADVNDPVFSSGAMGQGIAVKPSQGV
                     VYAPADAEVSIAFPTGHAFGLKTRNGAEVLIHVGIDTVSMNGDGFEAKVAQGNKVKAGD
                     VLGTFDSNKIAAAGLDDTTMVIVTNTADYASVAPVATGSVAKGDAVIEVKI"
     gene            7838..8725
                     /gene="scrK"
                     /locus_tag="A1M11_RS03170"
                     /old_locus_tag="ERS050419_00614"
     CDS             7838..8725
                     /EC_number="2.7.1.4"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0008865 - fructokinase activity [Evidence
                     IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="scrK"
                     /gene_functions="other (smcogs) SMCOG1108: ROK family
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000164317.1"
                     /locus_tag="A1M11_RS03170"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS050419_00614"
                     /product="fructokinase ScrK"
                     /protein_id="WP_000164302.1"
                     /transl_table=11
                     /translation="MTKLYGSLEAGGTKFVCAVGDENFNVVEKTQFPTTTPIETIDKTI
                     EFFSKFDNLAGLAVGSFGPIDIDKNSKTYGFITTTPKPNWANVDLLGALRRALNVPMYF
                     TTDVNSSAYGEMVARNNAGGRIENLVYYTIGTGIGAGVIQRGEFIGGVGHPEMGHYYVA
                     RHPMDIEKEFKGVCPFHKGCLEGYAAGPSLEARTGVRGETIELNNPVWDVQAYYIAQAA
                     VNATVTFRPDVIVFGGGVMAQQHMLDRVREKFTSLLNGYLPVPDVRDYIVTPAVAGNGS
                     ATLGNFVLAKEVSK"
     gene            complement(8768..9385)
                     /locus_tag="A1M11_RS03175"
                     /old_locus_tag="ERS050419_00615"
     CDS             complement(8768..9385)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000076166.1"
                     /locus_tag="A1M11_RS03175"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS050419_00615"
                     /product="TVP38/TMEM64 family protein"
                     /protein_id="WP_000076185.1"
                     /transl_table=11
                     /translation="MSQDKQMKAVSPLLQRVINISSIVGGVGSLIFCIWAYQAGILQSK
                     ETLSAFIQQAGIWGPPLFIFLQILQTVVPIIPGALTSVAGVFIYGHIIGTIYNYIGIVI
                     GCAIIFYLVRLYGAAFVQSVVSKRTYDKYIGWLDKGNRFDRFFIFMMIWPISPADFLCM
                     LAALTKMSFKRYMTIIILTKPFTLVVYTYGLTYIIDFFWQML"
     gene            complement(9800..>9988)
                     /locus_tag="A1M11_RS03180"
                     /pseudo=""
     CDS             complement(9800..>9988)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001153868.1"
                     /locus_tag="A1M11_RS03180"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="IS30 family transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="GSNKNHNKFIHRWLPQGTKKTTTKEVAFIEKWINNYPKKCLNYKS
                     PREDFWMTNLNLKFSNN"
     gene            complement(10381..10617)
                     /locus_tag="A1M11_RS13385"
                     /old_locus_tag="ERS050419_00616"
     CDS             complement(10381..10617)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="A1M11_RS13385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="ERS050419_00616"
                     /product="hypothetical protein"
                     /protein_id="WP_000836792.1"
                     /transl_table=11
                     /translation="MKSKEQTRKLAVGCSKYSFEVADKTDEVSSKHCFEVVDRTDEVSS
                     KHCFEVVDRTDEVSNYIYGKAKLTWFEEIFEEY"
     gene            10739..11632
                     /locus_tag="A1M11_RS03190"
                     /old_locus_tag="ERS050419_00617"
     CDS             10739..11632
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000895295.1"
                     /locus_tag="A1M11_RS03190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS050419_00617"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_000895292.1"
                     /transl_table=11
                     /translation="MLEVRSLEKSFGSKQVLFGIDFQARPGRILGLVGKNGAGKTTIFH
                     SILKFLEYQGEIGLDGQDIRQETYARIGYLPEERSLMPKLTVLEQVRYLATLKGMDAKE
                     VKEKLPQWMKRLEVKGKLTDKIKSLSKGNQQKIQLIITLIHEPDLIILDEPFSGLDPVN
                     TELLKQVIFQEKERGATIIFSDHVMTNVEELCDDILMIRDGRVVLHGPVQDVRNQYGKT
                     RLFVSSERSKEELENLPHVKQVSLTKQGSWKLILEDESAGRELFPILTQGQYIATFDQQ
                     APTIDEIFKLESGVEV"
     gene            11629..12828
                     /locus_tag="A1M11_RS03195"
                     /old_locus_tag="ERS050419_00618"
     CDS             11629..12828
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001245382.1"
                     /locus_tag="A1M11_RS03195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS050419_00618"
                     /product="ABC transporter permease"
                     /protein_id="WP_001245352.1"
                     /transl_table=11
                     /translation="MRNMWVVIKETYLRHVESWSFFFMVISPFLFLGISVGIGHLQGSS
                     MAKNNKVAVVTTVPSVAEGLKNVNGVNFDYKDEASAKEAIKEEKLKGYLTIDQEDSVLK
                     AVYHGETSLENGIKFEVTGTLNELQNQLNRSTASLSQEQEKRLAQTIQFTEKIDEAKEN
                     KKFIQTIAAGALGFFLYMILITYAGVTAQEVASEKGTKIMEVVFSSIRASHYFYARMMA
                     LFLVILTHIGIYVVGGLAAVLLFKDLPFLAQSGILDHLGDAISLNTLLFILISLFMYVV
                     LAAFLGSMVSRPEDSGKALSPLMILIMGGFFGVTALGAAGDNLLLKIGSYIPFISTFFM
                     PFRTINGYAEGAEAWISLAITVIFAVVATGFIGRMYASLVLQTDDLGIWKTFKRALSYK
                     "
     gene            complement(13181..13948)
                     /locus_tag="A1M11_RS03200"
                     /old_locus_tag="ERS050419_00619"
     CDS             complement(13181..13948)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000498762.1"
                     /locus_tag="A1M11_RS03200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS050419_00619"
                     /product="hypothetical protein"
                     /protein_id="WP_050200147.1"
                     /transl_table=11
                     /translation="MFWNLVRYEFKNVNKWYLALYAAVLVLSALIGIQTQGFKNLPYQE
                     SQATMLLFLATVFGGLMLTLGISTIFLIIKRFKGSVYDRQGYLTLTLPVSEHHIITAKL
                     IGAFIWSLISTAVLALSAVIILALTAPEWIPLSYVITFVETHLPQIFLTGISFLLNTIS
                     GILCIYLAISIGQLFNEYRTALAVAAYIGIQIVIGFIELFFNLSSNFYVNSLVGLNDHF
                     YMGAGIAIVKELIFIAIFYLGTYYILRNKVNLL"
     misc_feature    complement(13907..13922)
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 23.25"
                     /tool="antismash"
     gene            complement(13965..14660)
                     /locus_tag="A1M11_RS03205"
                     /old_locus_tag="ERS050419_00620"
     CDS             complement(13965..14660)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004256110.1"
                     /locus_tag="A1M11_RS03205"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS050419_00620"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_000055451.1"
                     /transl_table=11
                     /translation="MSLLVFENVSKSYGATPALENVSLDIPAGKIVGLLGPNGSGKTTL
                     IKLINGLLQPDQGRVLINDMDPSPATKAVVAYLPDTTYLNEQMKVKEALTYFKTFYKDF
                     NLERAHHLLADLGIDENSRLKKLSKGNKEKVQLILVMSRDARLYVLDEPIGGVDPAARA
                     YILNTIINNYSPTSTVLISTHLISDIEPILDEIVFLKDGKVVRQGNVDDIRYESGESID
                     QLFRQEFKA"
     gene            complement(14665..15030)
                     /locus_tag="A1M11_RS03210"
                     /old_locus_tag="ERS050419_00621"
     CDS             complement(14665..15030)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1136: GntR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004256112.1"
                     /locus_tag="A1M11_RS03210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS050419_00621"
                     /product="GntR family transcriptional regulator"
                     /protein_id="WP_000119153.1"
                     /transl_table=11
                     /translation="MSWTFDNKKPIYLQIMEKIKLQIVSHTLEPNQQLPTVRELASEAG
                     VNPNTIQRALSDLEREGFVYSKRTTGRFVTKDKELIAQSRKQLSEEELEHFVSSMTHFG
                     YEKEELPGVVSDYIKGV"
     gene            15170..15643
                     /gene="nrdR"
                     /locus_tag="A1M11_RS03215"
                     /old_locus_tag="ERS050419_00622"
     CDS             15170..15643
                     /GO_function="GO:0008270 - zinc ion binding [Evidence IEA]"
                     /GO_function="GO:0140110 - transcription regulator activity
                     [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene="nrdR"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001203675.1"
                     /locus_tag="A1M11_RS03215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS050419_00622"
                     /product="transcriptional regulator NrdR"
                     /protein_id="WP_001203672.1"
                     /transl_table=11
                     /translation="MRCPKCGATKSSVIDSRQAEEGNTIRRRRECDECQHRFTTYERVE
                     ERTLVVVKKDGTREQFSRDKIFNGIIRSAQKRPVSSDEINMVVNRIEQKLRGRNENEIQ
                     SEDIGSLVMEELAELDEITYVRFASVYRSFKDVSELESLLQQITQSSKKKKER"
     gene            15644..16813
                     /locus_tag="A1M11_RS03220"
                     /old_locus_tag="ERS050419_00623"
     CDS             15644..16813
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000802368.1"
                     /locus_tag="A1M11_RS03220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS050419_00623"
                     /product="replication initiation and membrane attachment
                     family protein"
                     /protein_id="WP_000802389.1"
                     /transl_table=11
                     /translation="MKPIDRFSYLKNNRVSQDTSSLVQCYLPIIGQEALSLYLYTISFW
                     DNGRKEYLFSSILNHLNFGMDRLIKSLKILSAFNLLTLYQKGDVYQLALHAPLSSQDFL
                     EHPVYRRLLEKKIGDSAVEDLKVESADGEEIPVSLNQVFPELAELGSQEDLGLKKKVAN
                     DFDLEHFRQLMARDGLRFADEQSDVLNLFAIAEEKKWTWFETYQLAKSTAVSQVISTKR
                     MREKIAQKPVSSDFSLKETTIIKEAKSKTALQFLAEIKQTRKGTITQTERELLQQMAGL
                     GLLDEVINIILLLTFNKVDSANINEKYAMKVANDYAYQKIHSAEKAVLRIRERGQKTKT
                     QKQNQTAPAKTNIPKWSNPEYKNTSSAEELEEMERQTLELLAKLDNGGD"
     gene            16814..17710
                     /gene="dnaI"
                     /locus_tag="A1M11_RS03225"
                     /old_locus_tag="ERS050419_00624"
     CDS             16814..17710
                     /codon_start=1
                     /gene="dnaI"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398880.1"
                     /locus_tag="A1M11_RS03225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS050419_00624"
                     /product="primosomal protein DnaI"
                     /protein_id="WP_000446516.1"
                     /transl_table=11
                     /translation="MESVGDVLKRQPSRFHYQDLVQKIMKDPDVAAFVQQESLNQDELN
                     RSISKFNQYITERDKFLRGDTDYIAKGYKPILVMNHGYADVSYEETPELIAAEKEAAIK
                     KRLNLINFPSSLKNVSFLDVYRDDVQRLTVLKRMIEFVNDYPNNLKGLYLYGDFGVGKS
                     FMVAALAHDLSEKRGVSSTLLHYPSFVIDVKNAIGDGNVKTLVDEIKLSEVLILDDIGA
                     EQSTAWVRDEILQVILQYRMQENLPTFFTSNFNFEDLEKHFAKGKNGNDETWEARRVME
                     RIRYLAEETRLEGVNRR"
     gene            17707..18420
                     /locus_tag="A1M11_RS03230"
                     /old_locus_tag="ERS050419_00625"
     CDS             17707..18420
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00881"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000140867.1"
                     /locus_tag="A1M11_RS03230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS050419_00625"
                     /product="NADPH-dependent oxidoreductase"
                     /protein_id="WP_000140850.1"
                     /sec_met_domain="PF00881 (E-value: 5.6e-23, bitscore: 74.6,
                     seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTETIKLMKAHTSVRRFKEQEIPQVDLNEILTAAQMASSWKNFQS
                     YSVIVVRSQEKKDALYELVPQEAIRQSAVFLLFVGDLNRAEKGARLHTDTFQPQGVEGL
                     LISSVDAALAGQNALLAAESLGYGGVIIGLVRYKSEEVAELFNLPDYTYSVFGMALGVP
                     NQHHDMKPRLPLENVVFEEEYQEQSTEAIQAYDRVQADYAGARATTSWSQRLAEQFGQA
                     EPSSTRKNLKQKKLL"
     gene            18434..19744
                     /gene="der"
                     /locus_tag="A1M11_RS03235"
                     /old_locus_tag="ERS050419_00626"
     CDS             18434..19744
                     /EC_number="3.6.5.-"
                     /GO_component="GO:0005737 - cytoplasm [Evidence IEA]"
                     /GO_function="GO:0003924 - GTPase activity [Evidence IEA]"
                     /GO_function="GO:0005525 - GTP binding [Evidence IEA]"
                     /GO_function="GO:0043022 - ribosome binding [Evidence IEA]"
                     /GO_process="GO:0042254 - ribosome biogenesis [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="der"
                     /gene_functions="other (smcogs) SMCOG1227: ribosome
                     biogenesis GTP-binding protein YsxC"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018377046.1"
                     /locus_tag="A1M11_RS03235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS050419_00626"
                     /product="ribosome biogenesis GTPase Der"
                     /protein_id="WP_061747053.1"
                     /transl_table=11
                     /translation="MALPTIAIVGRPNVGKSTLFNRVAGERISIVEDVEGVTRDRIYAT
                     GEWLNRSFSMIDTGGIDDVDAPFMEQIKHQAEIAMEEADVIVFVVSGKEGITDADEYVA
                     RKLYKTHKPVILAVNKVDNPEMRNDIYDFYALGLGEPLPISSVHGIGTGDVLDAIVENL
                     PNEYEEENPDVIKFSLIGRPNVGKSSLINAILGEDRVIASPVAGTTRDAIDTHFTDTDG
                     QEFTMIDTAGMRKSGKVYENTEKYSVMRAMRAIDRSDVVLMVINAEEGIREYDKRIAGF
                     AHEAGKGMIIVVNKWDTLEKDNHTMKNWEEDIREQFQYLPYAPIIFVSALTKQRLHKLP
                     EMIKQISESQNTRIPSAVLNDVIMDAIAINPTPTDKGKRLKIFYATQVATKPPTFVIFV
                     NEEELMHFSYLRFLENQIRKAFVFEGTPIHLIARKRK"
     misc_feature    19799..19810
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: strong, score: 19.14"
                     /tool="antismash"
     gene            19835..20170
                     /locus_tag="A1M11_RS03240"
                     /old_locus_tag="ERS050419_00627"
     CDS             19835..20170
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000400494.1"
                     /locus_tag="A1M11_RS03240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS050419_00627"
                     /product="hypothetical protein"
                     /protein_id="WP_000400493.1"
                     /transl_table=11
                     /translation="MEHLFKFLLLAPYFYFDNWIEKANRNSKFFPIFYYFYWFYIPFYS
                     LFSLAWTVVSVLFFNTVLRNVTDIKLWGIWFLFILLAIGMNWLTYSCFKEMFRLRQELG
                     KSKGGRH"
     gene            20311..20646
                     /locus_tag="A1M11_RS03245"
                     /old_locus_tag="ERS050419_00628"
     CDS             20311..20646
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000400498.1"
                     /locus_tag="A1M11_RS03245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS050419_00628"
                     /product="hypothetical protein"
                     /protein_id="WP_000400503.1"
                     /transl_table=11
                     /translation="MEHLFKMIILLPCFYFFSWIDKDNRESKFFPIFYYFYWIYITLYA
                     LFSLAWTVFSVLFFNIVLRNLTDIKLWGIWLLLLLIAFASDWLAYVFFKKMIRLRRELG
                     KSKGGRH"
     gene            20831..21622
                     /locus_tag="A1M11_RS03250"
                     /old_locus_tag="ERS050419_00629"
     CDS             20831..21622
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398883.1"
                     /locus_tag="A1M11_RS03250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS050419_00629"
                     /product="hypothetical protein"
                     /protein_id="WP_000701278.1"
                     /transl_table=11
                     /translation="MKIPLLTLARHKFVYVLLTLLFLALVYRDVLMTYFFFDIHAPDLA
                     KFDGQAIKNDLLKSALDFRILQFNLGFYQSFIIPIIIVLLGFQYIELKNKVLRLSIGRE
                     VSYQGLKRKLTLQVASIPCLIYLVTVLTIAIITYFLGTFSPLGWNSLFSDGSGLQRLLD
                     GEIKSYLFFTCVLLIGIFINAIYFLQIVDYVGNVTRSAIAYLMFLWLGSILLYSTLPYY
                     MVPMTSLMQASYGDVSLMKLFTPYILYVVPYMVLKKYEDNV"
ORIGIN
        1 cgtttaaaat gttttcaaca acctatcgaa atcatcgtaa acgcttcgga ttacgaatga
       61 atttgattgc tggcattatc aatcatgaac taggattcta gttttgcagg aagtctacta
      121 ctttccttat tgtctgtaaa tctactgacc ttgttgttta tcccagtcat ggtttctagt
      181 tcgggctcag agtttcaaag tggatggcaa gagcatcaat tgattgctga gaaggttagt
      241 aaaacacttg ataagacatt tgataaggat gtcagagaaa ttccgaccag tcagttttat
      301 caaaaatttg tagatgagat gggaaggact tactcaggaa atttgatcct ccaggagctg
      361 ataactgtga atggagctta taaagctact tatatcggtg aactctctag caactaatca
      421 ttctttaaaa tgatgaccaa taagaggctt gatttggtga atcaagtctt ttttctctct
      481 tttactgcca tttgtgataa aatagtatag aacgattttt tacatgaatg ataaaacaga
      541 ggtaaatatg acaatcggta ttgataagat tggttttgcg accagtcaat atgtcttgaa
      601 attacaagac ttagcagaag cgaggggaat tgaccctgaa aaattaagta aaggactctt
      661 actcaaggaa ttgagtattg cgcccctaac tgaggacatc gtgaccttgg cggccagtgc
      721 tagtgactct attttaactg agcaagaaag acaagaagtt gacatggtca ttgtggcgac
      781 cgagtcagga attgaccaga gtaaggctgc ggccgtcttt gtgcatggct tgctgggcat
      841 ccagcccttt gctcgtagtt tcgagattaa agaagcctgc tatggggcga ctgctgccct
      901 ccattatgcc aaattgcatg tggaaaattc tccggagtcc aaggtcttgg tcattgcaag
      961 tgatattgcc aaatacggta ttgaaactcc gggagaaccc actcagggtg ccggaagtgt
     1021 ggctatgttg attacacaaa atccacgcat gatggccttt aataatgaca atgtagctca
     1081 gacccgtgac atcatggatt tctggcgacc aaattactcg acaactcctt atgtaaatgg
     1141 tgtctattct acccaacaat acttggatag tttgaaaacg acttggcttg aatatcaaaa
     1201 acgctaccag cttactttgg atgattttgc ggctgtttgt ttccacttgc cttatcctaa
     1261 attagcgcta aaaggcttga aaaaaatcat ggataagagc ctgcctcaag agaaaaaaga
     1321 cctcttacaa aagcattttg accagtctat tctctacagt caaaaggtgg ggaatatcta
     1381 cacaggttca cttttccttg gacttttgtc tctcttggaa aatacagata gcttgaaagc
     1441 tggggataaa atcgcccttt atagttacgg aagtggagct gtggctgagt tcttcagtgg
     1501 tgaattggtt gaaggatatg aagcttattt ggataaagac cgcttgaaca agctcaacca
     1561 acgaactgtc ttatccgttg cagactatga aaaggtcttt tttgaggaag taaacttgga
     1621 tgaaacaaac tctgcccagt ttgctggcta tgaaaatcaa gattttgcct tggttgaaat
     1681 tctcgaccac caacgccgtt atagcaaggt tgaaaaataa tgaagataag ttggaatgga
     1741 ttttctaaaa aatcatacca agagcgcctc gagctgttaa aagctcaggc gctccttagt
     1801 cctgagagac aagctagtct ggagaaggat gaacagatga gcgtgactgt ggcagaccag
     1861 ctgagtgaga atgtagtggg aactttttct ctgccttatt cactggttcc ggaggtactt
     1921 gtcaacggtc aggaatacac cgttccctat gtgacagaag aaccctctgt ggttgcggcg
     1981 gccagctatg ccagcaaaat catcaagcgt gcaggtggtt ttactgcaca agtccatcag
     2041 cgacagatga ttgggcaggt agccctttat caagttgcta atcctaaact agcgcaagag
     2101 aagattgcca gcaagaaagc ggagctcttg gagcttgcca atcaagccta tccttctatc
     2161 gttaaacgtg gaggtggggc gcgtgatctg catgtcgagc agataaaagg cgaaccagac
     2221 tttctcgttg tttatattca tgtcgatacc caggaagcca tgggtgccaa tatgctcaac
     2281 accatgctgg aagccttgaa accagtctta gaagaactca gtcagggaca gagtctcatg
     2341 ggaatcctgt ccaactacgc gaccgattct ctggtgactg caagctgtcg catcgccttt
     2401 cgctacttga gccgccaaaa ggatcaagga cgagagattg cggagaaaat tgcgttggct
     2461 agtcagtttg cgcaggctga tccttaccga gctgctactc ataataaagg aatttttaat
     2521 ggtattgatg cgattttgat tgccactggt aatgactggc gtgccatcga agctggggcc
     2581 catgcctttg ccagtcgaga tggacgctat caaggtctta gttgctggac gctggacctt
     2641 gaaagagaag aattggtcgg tgagatgacc ctgcccatgc ctgtagcgac taagggtggc
     2701 tctatcggcc tcaacccacg tgtagctctc agtcatgatc tactaggaaa tccttctgcc
     2761 agagaattag cccagattat cgtgtccatc ggtcttgccc aaaattttgc agccctcaaa
     2821 gccttggtaa gtacgggcat ccagcaaggc cacatgaaac tacaggccaa atccctagct
     2881 ctcctagctg gggctagtga atctgaagtt gctcccctag tagagcgcct catctcagat
     2941 aaaaccttta acctagagac agcccagcgc tatctcgaaa atttaagatc ataaaaactc
     3001 agacgaatcg gtctgagttt tcttgtgttt aaatactttt tcctggtaat agtgtaactg
     3061 gtaagaagta accagttgtg gcgacttcct tgccttcaat cttttgcaag agaagatcaa
     3121 tagtgagaca agcaatctct tccaaaggtt gcttgatagt agccaattga gggtagtaat
     3181 tttcgataaa gtaggtccca tcatagccga taaccttgag ctcttttggg acagaaatgc
     3241 ccaattcttg agcgatttta atgatcagaa tagctgtcaa atcatccgaa gcaaaaatgg
     3301 catctggttt ttcccgggtc aagatattct tgatttccat ttcttttctg acgggagaaa
     3361 agtcactgga aacattgata ataggagctt ttgggagtac ggatgcaaaa ccagcgtggc
     3421 gcagtccggt tggcgaatta gaattgtcat tccctgtaat catgatgata gactgggcac
     3481 ctgtcttgac caaggtttgg gcagcaagaa ccccaccagc atagttgtca gaggagacga
     3541 cagggatgtc tggcgatagg tttcggtcaa aggaaataat cggcgctgtc acacgattgt
     3601 agtcttcgat tcctaggttg tgactaccag aaatgatgcc gtccacctga ttggcttcca
     3661 acatttcgat gtattcgcgt tccttctcag aatcatgttc actgttgcag atgatggtct
     3721 tgtaaccatt tttgaagagt tggtgttcca atttatcaat caattctgca tagaaaacat
     3781 tggaaatatt ggggaaaatc aagccgatta acttagctga ttttccttgc agactacgag
     3841 ccaggttgtt gggtttatag cccaattctc gcatggcttc attgactttt tggatggttt
     3901 tctcagatag ataccctttt ttattgataa cccgagaaac ggtagtagga ctgacgcctg
     3961 caagtttggc gacatcagtt agttttgcga ccataatcta attcatagta agttccagtt
     4021 gggtttccag atttgatcag gataccattt tggtccgcat gtgggaagac acgaccagaa
     4081 aatacttttt ctcctttatt gatgaaaatt tcaaagacag agttatcgat gaagattgta
     4141 gcagtagtag cctgattctc gatagggcaa gaacgagttg tcccaaattc ttgggcatac
     4201 tgttctccag cctggctacg atccactgtc acttgactgt ttacaaggtc aaagttgatt
     4261 gaaagtccct taccttcttt atcagcaagt aagacaatct cgctctggct attagcttcc
     4321 aagttgagtt caagttcgta agtgttcttg gtttgggaac ggtttgagaa ggcttcttca
     4381 gaagcacgaa ggtccttaat agcagctact ggatactggt agagcttgtc gtctttgata
     4441 gtgagttcct tgaccaaaga gaaggttcct tggtggtcaa aacggtcaga tgggtaagaa
     4501 acatctggca aaccaagcca gctaactgct agagcacgcc catcaggagc gttgaaggct
     4561 tgagttgcat aggcttcgaa accgtaatcc atgttttgaa gttgagacac atctaccatt
     4621 ttggcatttt tagggtcaaa ggaagcccca atcttataca tatttggaaa gatattatcg
     4681 tagtctagaa ctttcttatc caatccttgt ggacagtaga gaaggacagg ctgttcctct
     4741 acaaagacca gattaggaca ttccatcatg taggcagtac ggtcgttagc aaagtcaagg
     4801 tcgccaactg cttgccagtt tgtgtagtcg ttattgacag ccttgtagag acggacgaag
     4861 ccttttttct ccaagttctg tccaccgacg acagcatagt attgaccttt aaagttaaaa
     4921 atttgtggat cgcggaagtg gtcagtagag tctgctggct ggtcaatcaa gatcttgtca
     4981 atctttgtaa tcttaccctc cttgtccatc aaagcaccga tttggtatgg gtgacggatc
     5041 cagttttcat cgcgaacatt tcctgtataa aataggaata agttatcgcc aaattgcatg
     5101 gcagaaccag agtaggcacc gtggctatct aatggagtat ccggcaaaac tttgactcca
     5161 gtttctctaa agtgaatcaa atcatcactt tctagctgtg cccaagattt taaaccgtgg
     5221 gctgcaccaa aaggaaaatt ctggtaaaag aggatccact tgccatcaaa gtaagaaaag
     5281 ccatttgggt cgttgagaag tcctgttttt ggctcaacat ggtaatgagt atgccatgga
     5341 gattgtgcca tattttcctt tatatgttga atttcttctt gcgtccaatc ttgataaagt
     5401 ctgtaacgac gctcagttgt ccattccatt cattcctcca aaaatcttat cacttttaat
     5461 agtaactgtt ttcgataaaa aatgcaagcc ctttatgtta aaaaagagaa aaaactgtca
     5521 aacgattatc ataaaataaa tacaggaaat caatcaaatt tttacgaaaa tgtgaaagat
     5581 aatgaaataa aagacttttt aaccaaggtt tcaaacttat ttttcaagaa attcctgatg
     5641 aaacagtcaa aaacaatcaa tctaaagctt gcccactaag tagatagaat attttttctg
     5701 caaaacgctt gacatatttt taaaacatga taaaataata gtcgtaaggg cgaataaaat
     5761 cgctttcaaa caagaacaaa atgttatata aggagatttt tgcaaatgaa caatcaggaa
     5821 attgcaaaaa aagtcatcga tgccttgggc ggacgtgaaa atgtcaatag tgttgcccac
     5881 tgtgcgactc gtctacgtgt catggtcaaa gatgaagaga aaatcaataa agaagtgatt
     5941 gagaacttgg aaaaagttca aggtgctttc tttaactcag ggcaatacca aattatcttt
     6001 ggtacaggta cagttaacaa aatgtacgat gaagttgttg tacttggctt accaacatca
     6061 tctaaggatg acatgaaagc agaagttgct aaacaaggga actggttcca acgtgctatc
     6121 cgtactttcg gtgatgtttt cgttccaatc atcccagtta tcgtagcgac aggtctcttc
     6181 atgggtgtgc gtggtctttt caacgctctt gaaatgccac ttccaggtga ctttgcaact
     6241 tacacacaaa tcttgacaga tacagccttc atcatcttgc caggtttggt tgtgtggtca
     6301 accttccgtg tatttggtgg aaatcctgcc gttggtatcg ttcttggtat gatgcttgtc
     6361 tctggctcac ttccaaacgc ttgggcagtt gctcaaggtg gtgaagtaac agcgatgaac
     6421 ttctttggtt tcatccctgt tgttggtttg caaggttccg ttcttccagc cttcatcatc
     6481 ggggttgtcg gagctaaatt tgaaaaagct gtccgcaagg ttgttccaga tgtcattgac
     6541 ctcttggtaa caccattcgt gacacttttg gtcatgtcta tccttggact ctttgtcatt
     6601 ggaccagttt tccacgttgt tgaaaactac atccttattg ctacaaaagc gattcttagc
     6661 atgccatttg gtcttggtgg tttcttgatt ggtggggttc accaattgat cgtcgtgtca
     6721 ggtgtgcacc acatcttcaa cttgcttgaa gtgcaattac ttgctgctga ccatgctaac
     6781 ccattcaacg ctatcatcac agctgctatg acagctcaag gtgctgctac tgttgcggtt
     6841 ggtgttaaaa caaaaaatcc aaaactgaaa acacttgctt tcccggctgc tctttctgcc
     6901 ttcctaggta ttacagagcc tgctatcttc ggggtgaact tgcgcttccg taaaccattc
     6961 ttcctttcac tgattgctgg tgcaatcggt ggtggattgg cttctatcct tggacttgct
     7021 ggtactggta atggtatcac catcatccct ggtacaatgc tttatgttgg taacggacaa
     7081 cttccacaat accttcttat ggtagctgta tcatttgccc ttggttttgc tcttacttac
     7141 atgtttggtt acgaagatga agtagacgca actgcagctg caaaacaagc tgaagtggct
     7201 gaagaaaaag aagaagttgc gccagcagct cttcaaaatg aaacacttgt aactcctatc
     7261 gttggtgatg ttgtcgctct tgctgatgtc aatgacccag tcttctcaag tggagctatg
     7321 ggacaaggta tcgctgtgaa accaagccaa ggcgtggtct atgcaccagc tgatgctgaa
     7381 gtttcaattg cctttccaac agggcacgct tttggtttga aaacaagaaa tggtgctgaa
     7441 gttttgattc acgttggtat tgacactgta tctatgaacg gtgacggttt tgaagcaaaa
     7501 gttgctcaag gtaataaggt gaaagctggc gatgttcttg gaacatttga ctcaaacaaa
     7561 atcgctgcag ctggacttga tgatacaaca atggttatcg ttacaaatac agctgactac
     7621 gcttcagtag ctccagtcgc aacaggttca gttgcgaagg gggatgctgt gatcgaagtg
     7681 aaaatctaat caatcctctc taatgtgaaa acgaacaaat gacatgtttg ttcgttttta
     7741 ttagatagta agatttacag aggaaaatct aaaaaataga gacatttaga ctttcgaagt
     7801 atgctataat aaagaaaata aaaacaagag gtttatcatg acaaaattat atggaagctt
     7861 ggaagcgggc ggtacaaagt ttgtctgtgc tgtcggtgat gaaaacttta acgttgtaga
     7921 aaaaacacaa tttccaacaa caactccaat cgaaacaatc gataaaacca ttgagttctt
     7981 ctcaaaattc gataaccttg ctggtcttgc agttggttca tttgggccga ttgatattga
     8041 caaaaactca aaaacttatg gctttatcac gacgactcca aaaccaaact gggcaaatgt
     8101 ggacttgctt ggtgcccttc gtcgcgccct aaacgtgcca atgtacttca caacagacgt
     8161 aaacagctct gcttacggtg aaatggttgc ccgtaacaat gctggtggtc gtatcgaaaa
     8221 cttggtttac tacacaatcg gtacaggtat cggtgcaggc gtcatccaac gtggtgagtt
     8281 tatcggtggt gtgggtcacc ctgaaatggg tcattattat gttgctagac acccaatgga
     8341 tattgaaaaa gagtttaagg gtgtttgtcc tttccataag ggatgtctgg aaggctatgc
     8401 agctggtcca agtttggaag ctcgtacagg tgtacgtggg gaaactattg aactcaacaa
     8461 ccctgtttgg gatgttcaag cctactatat cgctcaagct gcggttaatg cgacagtgac
     8521 tttccgccca gacgtgattg tctttggtgg aggggtcatg gctcaacaac atatgctgga
     8581 ccgtgtccgt gagaaattta catctcttct taatggttac ctaccagtac cagatgtgcg
     8641 tgactatatc gtgacgccag cagtcgcagg aaatggttct gccacacttg ggaactttgt
     8701 tcttgcaaaa gaagtttcaa aataaagcac aaaatccgct tgggaaacca aacggatttt
     8761 ttacgtgtca aagcatttgc cagaaaaagt caataatata ggtcagaccg taggtataaa
     8821 ccacgagggt aaagggtttg gtcagaatga tgatggtcat gtagcgcttg aaactcatct
     8881 tggtcagggc agccagcata cagagaaagt cagctgggct aatgggccaa atcatcataa
     8941 aaataaagaa gcggtcaaaa cgattgccct tatctagcca gccgatgtac ttgtcgtagg
     9001 tgcgcttgct gacgacagac tggacaaagg cagctccgta taggcgcact agataaaaga
     9061 taatggcaca gccaatcacg atgccgatat agttgtagat agtcccgatg atgtgcccgt
     9121 agataaagac cccagccacc gaggtcaagg cccctggaat gatagggacg acagtctgta
     9181 aaatctgtaa aaagataaag agaggtggac cccagatgcc tgcctgctgg ataaaggcag
     9241 agagggtttc cttggattgt aaaatcccag cctgataagc ccaaatacag aaaatcaaac
     9301 tcccaacccc accgacaatc gatgagatat tgataactcg ctgcagaagg ggagaaacag
     9361 ctttcatttg tttatcctgt gacatgtaaa ctcctcatag atagtatatt tctactatac
     9421 catattttgg aggagaaagg gggaatgagt cttttttgat aaggaataga aagtaaatag
     9481 cccttcgaga cttagaatag gtctgtcaac taaaggttat atgcattcta ggtttcgaat
     9541 aatcgcaatt ccatgaattt aaaagcattc taagtttcga atagcttatc tgagataatt
     9601 ttgaggcatt cgcgctttcg aatagtcatt ttccctaaag tttagatgta ttctgaagct
     9661 agaaagacta aaatctaaaa gtagtaagag tctctctctg atggacgtaa tttatggcta
     9721 gtatgaatcc tttgaattgt tagttaattt taatattaat cagttctgaa ataattacta
     9781 aatatagtta gatggtgaat taattattgc taaatttcaa gttcaagtta gtcatccaga
     9841 agtcttctct gggggacttg tagttcaagc attttttagg atagttgtta atccactttt
     9901 cgatgaatgc gacttccttt gtagtcgttt tcttagttcc ctgaggtaac catctatgaa
     9961 tgaacttgtt gtgattttta ttagatccta tagtggtgtg cataatagat ataatagatt
    10021 gaaactagaa tagtacgcat ctacttctaa aacattgtta gaaatcgatt tgactgtccc
    10081 gatctatttg tcctgttttt atttcatttt gctatataat ccttagaaaa catatcggac
    10141 aagcggttga attccgttcc gtccattagt agataaagga ttactccttc ttgaaatgac
    10201 agatgaactt gtttcttata aaaatgttgt ctgaaactat tcgctttttt ccagaagttt
    10261 tagaggaaga aaactttatg aggaaaaagg agttactcaa ataacaattc aggattaaaa
    10321 atagacagtt gaggagcgga aggtataaat taagtttgct actgtataat ggatttatca
    10381 ctaatactct tcgaaaatct cttcaaacca cgtcagcttc gccttgccgt agatatagtt
    10441 actgacttcg tcagttctat ccacaacctc aaaacagtgt tttgagctga cttcgtcagt
    10501 tctatccaca acctcaaaac agtgttttga gctgacttcg tcagttttat ctgcaacctc
    10561 aaagctgtac tttgagcagc ctacggctag cttcctagtt tgctctttgc ttttcattga
    10621 gtataaaagt gctccaggcc atattttaca cagcaatagt cttctaaaaa tggacaaaaa
    10681 cattgtaaag gctatcaaaa aggagtataa tgagtgcaag aaatttcgga ggtgaaagat
    10741 gctagaagta agaagtctag agaaaagttt tggctccaag caagttttgt ttggtattga
    10801 ctttcaagcg cgaccaggtc gtattttggg actagtcgga aaaaatggtg ctggaaaaac
    10861 aacgattttc catagtattt tgaaattcct agaatatcag ggagaaatcg gtctggatgg
    10921 tcaggatatt cgtcaggaga cctatgctcg gattggttat ctgcctgaag aacgcagtct
    10981 catgcctaaa ttgacagttc ttgaacaagt tcgctacttg gcgactctaa aaggcatgga
    11041 tgccaaagaa gtcaaagaaa aactccctca atggatgaag aggttggaag tgaaaggaaa
    11101 gctgacagat aaaatcaaga gtctgtcaaa aggaaatcag cagaagattc agctcattat
    11161 tactctgatt catgaaccag acctgattat cttggatgag ccttttagtg gattggaccc
    11221 agttaataca gaattgctca aacaagtcat ttttcaggaa aaagagcgcg gagcaaccat
    11281 tatcttttct gaccatgtca tgaccaatgt tgaggaactt tgtgacgata ttctgatgat
    11341 ccgagatggc cgtgtggtct tgcacggacc agttcaggat gtccgcaatc aatacgggaa
    11401 aacgcgtctc tttgtttcaa gtgaacgaag caaggaagaa ttggaaaatc ttcctcatgt
    11461 caaacaggtg agcttgacca aacaaggcag ttggaaattg attttggagg atgagagcgc
    11521 tggaagggaa ctcttcccaa tcttgactca aggtcaatat atcgcaacat ttgaccaaca
    11581 agcgccaact atcgatgaaa tctttaaact agaatcagga gtggaagtat gagaaatatg
    11641 tgggttgtaa tcaaggaaac ctatcttcga catgtcgagt catggagttt cttctttatg
    11701 gtgatttcgc cgttcctctt tttaggaatc tctgtaggaa ttgggcatct ccaaggttct
    11761 tctatggcta aaaataataa agtggcagta gtgacaacag tgccatctgt agcagaagga
    11821 ctgaagaatg taaatggtgt taacttcgac tataaagatg aagcaagtgc caaagaagca
    11881 attaaagaag aaaaattaaa aggttatttg accattgatc aagaagatag tgttctaaag
    11941 gcagtttatc atggcgaaac atcgcttgaa aatggaatta aatttgaggt tacaggtaca
    12001 ctcaatgaac tgcaaaatca gcttaatcgt tcaactgctt ccttgtctca agagcaggaa
    12061 aaacgcttag cgcagacaat tcaattcaca gaaaagattg atgaagccaa ggaaaataaa
    12121 aagtttattc aaacaattgc agcaggtgcc ttaggattct ttctttatat gattctgatt
    12181 acctatgcgg gtgtaacagc tcaggaagtt gccagtgaaa aaggcaccaa aattatggaa
    12241 gtcgtctttt ctagcataag ggcaagtcac tatttctatg cgcggatgat ggctctgttt
    12301 ctagtgattt taacgcatat tgggatctat gttgtaggtg gtctggctgc cgttttgctc
    12361 tttaaagatt tgccattctt ggctcagtct ggtattttgg atcacttggg agatgctatc
    12421 tcactgaata ccctgctctt tattttgatc agtcttttca tgtacgtagt cttggcagcc
    12481 ttcctaggat ctatggtttc tcgtcctgag gactcaggga aagccttgtc gcctttgatg
    12541 attttgatta tgggtggttt ttttggagtg acagctctag gtgcagctgg tgacaatctc
    12601 ctcttgaaga ttggttctta tattcccttt atttcgacct tctttatgcc gtttcgaacg
    12661 attaatggct atgcggaggg agcggaagca tggatttcac ttgctattac agtgattttt
    12721 gcggtggtag caacaggatt tatcggacgc atgtatgcta gtctcgttct tcaaacggat
    12781 gatttaggga tttggaaaac ctttaaacgt gccttatctt ataaatagaa gagccttgcg
    12841 aaagcgaggt ttttaaaggt gaaaagggtg gaatcacgaa cctaattatg tacacattat
    12901 gtaaacaggt tgcttgaaaa ctcaattgta tagtgaactg aatctggaat aggataatat
    12961 tacttctaaa acattcttat aaattgattt gaattccaaa atcccatcgt tccgttctta
    13021 tttcattttg cgatatagcg aaaggaaata agtcagctca caaaaaacgc ataatatcaa
    13081 ggatttttaa cacttgatac tatgcgtttt ctaattttaa agactttttg cctggtctct
    13141 tttgttctat gagtatgtta catatctagg taaaaattat ttaaagcaaa ttaaccttat
    13201 ttctcaagat gtagtaggtt ccgagataaa agatagctat gaatatgagt tctttaacaa
    13261 tggctatacc tgctcccata tagaaatggt cattgagtcc taccagtgaa ttgacataga
    13321 aattggaact aagattgaag aaaagttcaa taaatccaat gacgatttgg ataccaatgt
    13381 aggctgcaac agcgagtgct gtacggtatt cattgaaaag ctgtccaatg gaaatagcca
    13441 ggtagatgca gaggattcct gaaatggtat ttagtaggaa ggatatacct gtaagaaaga
    13501 tctgagggag atgtgtttct acaaatgtaa tcacataaga aagaggaatc cattctggag
    13561 ctgttaaagc cagaataata acagcactta gagccaatac agcggtgcta atcaatgacc
    13621 agataaaggc accgattagt ttggctgtga tgatatggtg ttcagaaact ggcaaggtca
    13681 aagtcagata gccttgtcgg tcgtagacac tacctttgaa gcgtttaata atcaagaaaa
    13741 tggttgaaat cccaagtgta agcatcaagc caccaaagac tgtagctaga aaaagtagca
    13801 tagtagcctg actttcttgg taaggtagat ttttaaagcc ttgtgtctgt attccgatga
    13861 gggcagaaag gactagcacg gctgcgtaga gggctaaata ccacttgtta acatttttaa
    13921 attcgtagcg aactaaattc caaaacataa ataatctcct ttgcttaggc cttaaattcc
    13981 tgacggaaga gttggtcaat ggattcacct gactcgtagc gaatatcatc tacatttcct
    14041 tgacggacga cttttccgtc ttttaggaag acaatttcat ccaagattgg ctcgatatca
    14101 gaaatcaagt gggtagaaat caaaacggta gaagttggtg agtagttgtt gataatggta
    14161 ttgaggatat aagcacgggc tgctggatcc accccaccaa tgggttcgtc caaaacatag
    14221 agacgagcat cacggctcat aaccaaaatc agttgaacct tttctttgtt tccttttgat
    14281 agtttcttga gacgactatt ttcatcaatg cccaggtctg caagtagatg atgggcgcgt
    14341 tcaagattga aatctttata gaaggtcttg aagtaggtta gggcttcttt gaccttcatt
    14401 tgctcattga gataggtcgt atcaggcaaa taagctacaa cggccttggt tgctgggctt
    14461 gggtccatgt cgttgatgag gacacgtcct tgatctggtt gtaagaggcc attaattagt
    14521 ttaatcaggg ttgtttttcc tgagccgttt ggcccaagaa ggccgacaat ttttccagct
    14581 ggaatgtcaa gagaaacatt ttcaagggct ggtgttgctc catatgattt ggatacattt
    14641 tcaaatacta gtaatgacat aggcttaaac tcctttaata taatcactga ctacgcctgg
    14701 tagttcttct ttttcatagc caaaatgggt catggaggaa acgaagtgtt ccaattcttc
    14761 ttctgataat tgtttgcgtg actgggcgat tagctcctta tccttagtca caaatcgtcc
    14821 agttgttcgc ttgctgtaga caaatccttc tcgttcaagg tctgataagg ctctttggat
    14881 ggtattggga ttgacaccag cctcgctagc tagctccctc acggttggaa gttgttgatt
    14941 gggttccagt gtatgggaaa caatctgaag cttgattttc tccataatct gtaaatagat
    15001 gggttttttg ttgtcaaatg tccaggacat cttagtctcc tttctcttat ccttttgtct
    15061 taattaaata atacaacaaa acaaaaaact tgtcaagcaa aaagaagaat tgttttggga
    15121 atcgcttaaa aaatggtata atgaaaagaa aacgataagg agggaaagga tgcgttgtcc
    15181 aaaatgtggg gctaccaagt caagtgttat cgatagtcgc caagcagaag aagggaacac
    15241 cattcgtaga agacgagagt gcgacgagtg ccaacaccgt tttacaacct acgaacgagt
    15301 agaagaaaga accttagtgg ttgttaaaaa agatggcaca cgggaacaat tctccagaga
    15361 taaaatcttt aatgggatta tccgctcagc ccagaaacgt cctgtgtcaa gtgatgaaat
    15421 caacatggta gtcaatcgta tcgaacagaa actccgtggt cgaaatgaaa atgaaattca
    15481 aagtgaggac attggttcac ttgtcatgga ggagttggct gaattggacg agattaccta
    15541 tgtacgtttt gctagtgtct atcgtagttt taaggatgtc agtgagttag agagcttgct
    15601 ccaacaaatc acccagtcct ctaaaaagaa aaaggaaaga taaatgaagc caattgaccg
    15661 tttttcttat ctaaagaata atcgggtgtc gcaagatacc tcatctctgg tacagtgcta
    15721 cctcccgatt atcggtcagg aggcactgag cctttatctt tatacaatca gtttttggga
    15781 taatggtaga aaggaatatc ttttttcaag tatcctcaat catctcaact ttgggatgga
    15841 tagactgata aaatcattga aaatcttatc tgcttttaat ctcttgaccc tctatcaaaa
    15901 gggggatgtt tatcagctag ccctccatgc tcctctatct agtcaagact tcttggagca
    15961 tcctgtttat cgcagactct tagagaaaaa gattggcgac tctgctgtgg aggatttgaa
    16021 agttgaaagt gctgatggtg aagaaatacc tgtctcactc aatcaagtct ttccagaatt
    16081 ggcagaacta ggcagtcaag aagaccttgg tctcaagaag aaagtggcca atgattttga
    16141 cttggaacat tttcgccagc tgatggctcg agatggactt cgttttgcgg atgagcagtc
    16201 cgatgtctta aacctctttg ctattgccga ggagaagaaa tggacttggt ttgaaaccta
    16261 tcaattggcc aagtcaacag ctgtttctca ggttatttca accaaacgca tgcgtgaaaa
    16321 aattgctcaa aaaccagttt cctctgactt tagtcttaag gaaacaacca ttatcaaaga
    16381 agccaaaagt aaaactgccc tgcagttctt ggcagaaatc aagcaaacac gcaagggaac
    16441 cattacccaa acagaaagag aactcttgca acagatggct ggcttgggct tgctggacga
    16501 agtcatcaat atcattcttt tattgacctt taataaggtc gattcggcaa atatcaatga
    16561 gaaatatgcc atgaaggtag ccaatgacta tgcctatcaa aagattcatt cggcagaaaa
    16621 ggcagtcttg cgcatccgtg agcgagggca gaaaacaaaa acacaaaaac agaatcagac
    16681 tgccccagca aaaaccaata ttcctaaatg gagtaatcct gaatataaaa atacgtcatc
    16741 cgctgaggaa ttagaagaga tggaacgcca aaccctagaa ttattagcaa aattagataa
    16801 cggaggtgat tagatggaaa gtgtcggaga tgtactcaaa cgtcaaccaa gtcgttttca
    16861 ctatcaagat ttagttcaga aaatcatgaa ggatcctgat gttgcggcct ttgtccagca
    16921 agaatccctc aatcaggacg agttgaaccg tagtatttcc aagtttaacc aatacatcac
    16981 tgagagagat aaattcctcc gaggagatac agattatatt gccaaaggct acaagcctat
    17041 attagtcatg aaccatggct atgcggatgt ttcttatgaa gaaactcctg aactaatcgc
    17101 agctgaaaaa gaagcggcta tcaagaaacg tctcaactta attaattttc catctagcct
    17161 gaaaaatgtc agttttttag atgtttatcg tgatgatgtt cagcgcttaa ctgttctaaa
    17221 aagaatgata gaatttgtta acgattaccc caataatttg aaaggtcttt acttatatgg
    17281 agactttggt gtgggtaaaa gtttcatggt ggctgcccta gctcatgatt tatcagaaaa
    17341 acgtggtgta tcatccactc tcctccacta tcctagcttt gtcattgatg tcaaaaatgc
    17401 tatcggtgat ggcaatgtta agaccttagt ggatgagatt aagctttctg aagtcctgat
    17461 tttagatgat attggtgccg agcaatccac cgcttgggtg cgtgatgaaa tcctgcaggt
    17521 cattctccaa tatcggatgc aggaaaattt accgaccttt ttcacctcta acttcaactt
    17581 tgaagatttg gagaagcatt tcgctaaagg gaaaaatgga aatgacgaaa cctgggaagc
    17641 cagacgtgtc atggaacgca tccgttattt ggctgaggag actcgtttag aaggagtaaa
    17701 ccgtcgatga cagaaaccat taaattgatg aaggctcata cttcagtgcg caggtttaaa
    17761 gagcaagaaa ttccccaagt agacttaaat gagattttga cagcagccca gatggcatca
    17821 tcttggaaga atttccaatc ctactctgtg attgtggtac gaagtcaaga gaagaaagat
    17881 gccttgtatg aattggtacc tcaagaagcc attcgccagt ctgctgtttt ccttctcttt
    17941 gtcggagatt tgaaccgagc agaaaaggga gcccgacttc ataccgacac cttccaaccc
    18001 caaggtgtgg aaggtctctt gattagttcg gtcgatgcag ctcttgctgg acaaaacgcc
    18061 ttgttggcag ctgaaagctt gggctatggt ggtgtgatta tcggtttggt tcgatacaag
    18121 tctgaagaag tggcagagct ctttaaccta cctgactaca cctattctgt ctttgggatg
    18181 gcactgggtg tgccaaatca acatcatgat atgaaaccga gactgccact agagaatgtt
    18241 gtctttgagg aagaatacca agaacagtca actgaggcaa tccaagctta tgaccgtgtt
    18301 caggctgact atgctggagc gcgtgcgacc acaagctgga gtcagcgtct agcagaacag
    18361 tttggccaag cagaaccaag ctcaactaga aaaaatctta aacagaagaa gttattgtag
    18421 aaagtgagaa attatggccc taccaactat tgccattgta ggacgtccca atgttgggaa
    18481 atcaacccta tttaatcggg tcgctggtga gcgaatctcc attgtagaag atgtcgaagg
    18541 agtgacacgt gaccgtatct atgcaacggg tgagtggctc aatcgctctt ttagtatgat
    18601 tgatacagga ggaattgatg atgtcgatgc tcctttcatg gaacaaatca agcaccaggc
    18661 agaaattgcc atggaagaag cagatgttat cgtttttgtc gtgtctggta aggaaggaat
    18721 tactgatgca gacgaatacg tagctcgtaa gctttataag acccacaaac cagttatcct
    18781 cgcagtcaac aaggtggaca accctgagat gagaaatgat atctatgatt tctatgctct
    18841 cggtttgggt gaaccactgc ctatctcatc tgtccatgga atcggtacag gggatgtact
    18901 agatgcgatt gtggaaaacc ttccaaatga atatgaagaa gaaaatccag atgtcattaa
    18961 gtttagcttg attggtcgtc ctaacgttgg aaaatcaagc ttgattaatg ctatcttggg
    19021 agaagaccgt gtcattgcca gtcctgttgc tggaacaact cgtgatgcca ttgataccca
    19081 ctttacagat acagatggtc aagagtttac catgattgat acggctggta tgcgtaagtc
    19141 tggtaaggtt tatgaaaata ctgagaagta ctctgtcatg cgtgccatgc gtgctattga
    19201 ccgttcagat gtggtcttaa tggtcatcaa tgcggaagaa ggcattcgtg agtacgacaa
    19261 gcgtatcgca ggatttgccc atgaagctgg taaagggatg attatcgtgg tcaacaagtg
    19321 ggatacgctt gaaaaagata accacactat gaaaaactgg gaagaagata tccgtgagca
    19381 gttccaatac ctgccttacg caccgattat ctttgtatca gctttaacca agcaacgtct
    19441 ccacaaactt cctgagatga ttaagcaaat cagcgaaagt caaaatacac gtattccatc
    19501 agctgtcttg aacgatgtca tcatggatgc cattgccatc aacccaacac cgacagacaa
    19561 aggaaaacgt ctcaagattt tctatgcgac ccaagtggca accaaaccac caacctttgt
    19621 catctttgtc aatgaagaag aactcatgca cttttcttac ctgcgtttct tggaaaatca
    19681 aatccgcaag gcctttgttt ttgagggaac accgattcat ctcatcgcaa gaaaacgcaa
    19741 ataaaaaagt agaatctgga atgacagttc cggatttttt tgatataata aaataataga
    19801 aaacgctatc aaaagaaaga gggtgatgtc ggtgatggaa catttgttta aattcttact
    19861 tttagcaccg tacttttatt ttgataactg gattgagaag gccaacagaa atagtaagtt
    19921 ttttccaatt ttttattatt tttactggtt ttacatcccc ttctattctc tttttagcct
    19981 tgcttggaca gttgtttcag ttctgttttt caataccgtc ttgagaaatg tgacagatat
    20041 caagttatgg ggcatttggt ttctttttat tctgctagct attggtatga attggttaac
    20101 ttattcctgt ttcaaagaaa tgtttcgctt gagacaggaa ctagggaagt ctaagggtgg
    20161 aaggcattga tttatatcgg tttctatttg taggaggtgg ccttatggta cctctaaaat
    20221 catttattac acgctattcc aaggtttata ttggtaataa catttaatag aacgaaacta
    20281 aagaaaacaa tttaaaagag gaggtttgtg atggaacact tgtttaaaat gataatctta
    20341 ttaccctgtt tttacttttt cagctggatt gacaaggata atagagaaag taaatttttc
    20401 ccaatttttt actattttta ctggatttac atcaccctct atgctctttt tagccttgct
    20461 tggacagttt tttcagttct gtttttcaat atcgtcttga gaaatttgac agatatcaag
    20521 ttatggggta tttggctatt attactactt atcgcttttg ctagtgattg gttagcctat
    20581 gtctttttca aaaaaatgat tcgcttgagg cgggaactag ggaaatctaa aggcggaagg
    20641 cattgattta tactcttcga aaatctcttc aaaccacgtc aacgtcgcct tggattatat
    20701 atgtaactga cttcgtcagt cttatctaca acctcaaagc agtgctttga gcaacttgcg
    20761 gctagtttcc tagtttgctc tttgattttc attgagtatt atattacttt ctatttgtag
    20821 gaggtggctt atgaagattc ctctcttaac tttggcaagg cataaatttg tttatgtctt
    20881 acttactttg ctttttcttg ctttggttta tcgtgacgtt ttgatgactt atttcttttt
    20941 tgatattcat gcgcccgatc tagctaaatt cgatggacaa gcaattaaaa atgacttatt
    21001 aaaatcagca ttagattttc gtattctcca gttcaatcta ggtttttatc aatcatttat
    21061 tattccaatc atcattgttt tgctaggttt tcaatatatt gagctgaaaa ataaagtttt
    21121 acgattgagt attggaagag aagtgagcta tcaagggtta aaaagaaagt tgactttgca
    21181 agttgcaagt atcccttgtt tgatatattt agtgactgtg ctgacaattg caattataac
    21241 ctatttcctt gggacttttt ctcctcttgg atggaattct ctattttctg atggaagtgg
    21301 tttacaaaga ctcctagatg gagagataaa aagctatttg ttctttactt gtgtcctact
    21361 aatcggtatt ttcatcaatg caatctattt tttacaaata gttgattatg tggggaatgt
    21421 gactcgttcg gcaatcgcct atttgatgtt tctttggctt ggttctatat tactctatag
    21481 taccttgcct tactatatgg ttcctatgac gagtttgatg caagctagct atggggatgt
    21541 aagtttgatg aaactcttta ctccttatat cctttatgtt gtcccttata tggtacttaa
    21601 aaaatatgaa gataatgttt aagaatttta acaatatttt gctaaagaga aagattgttt
    21661 tactacttcg tatagttctg atgatgattt tgataaacca tctattgtca acagcggttc
//
