LOCUS       NZ_FEEQ01000001        22991 bp    DNA     linear   CON 04-JAN-2025
DEFINITION  Streptococcus pneumoniae strain 2842STDY5644069, whole genome
            shotgun sequence.
ACCESSION   NZ_FEEQ01000001
VERSION     NZ_FEEQ01000001.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1
  CONSRTM   Pathogen Informatics
  TITLE     Direct Submission
  JOURNAL   Submitted (04-FEB-2016) SC, Wellcome Trust Sanger Institute, CB10
            1SA, United Kingdom
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_900047005.1-RS_2025_01_04
            Annotation Date                   :: 01/04/2025 01:43:28
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.9
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 2,253
            CDSs (total)                      :: 2,202
            Genes (coding)                    :: 2,019
            CDSs (with protein)               :: 2,019
            Genes (RNA)                       :: 51
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1, 1 (5S, 16S, 23S)
            tRNAs                             :: 45
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 184
            CDSs (without protein)            :: 183
            Pseudo Genes (ambiguous residues) :: 0 of 184
            Pseudo Genes (frameshifted)       :: 86 of 184
            Pseudo Genes (incomplete)         :: 88 of 184
            Pseudo Genes (internal stop)      :: 60 of 184
            Pseudo Genes (multiple problems)  :: 40 of 184
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 19:55:45
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 214202
            Orig. end                         :: 237193
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            FEEQ01000001.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22991
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-ii"
                     /region_number="2"
                     /rules="cds(LANC_like and DUF4135)"
                     /tool="antismash"
     cand_cluster    1..22991
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="cds(LANC_like and DUF4135)"
                     /kind="single"
                     /product="lanthipeptide-class-ii"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22991
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12991](-)"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12991)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
     gene            complement(112..459)
                     /locus_tag="A1T31_RS01095"
                     /old_locus_tag="ERS367508_00209"
     CDS             complement(112..459)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000434646.1"
                     /locus_tag="A1T31_RS01095"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS367508_00209"
                     /product="thioredoxin"
                     /protein_id="WP_000434643.1"
                     /transl_table=11
                     /translation="MEQFLDNIKDLEVTTVVRAQEALDKKETATFFIGRKTCPYCRKFA
                     DTLSGVVAETKAHIYFINSEEPSQLNDLQAFRSRYGIPTVPGFIHITDGQINVRCDSSM
                     SAQEIKDFAGL"
     gene            686..1942
                     /locus_tag="A1T31_RS01100"
                     /old_locus_tag="ERS367508_00210"
     CDS             686..1942
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1206: transposase"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000436265.1"
                     /locus_tag="A1T31_RS01100"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS367508_00210"
                     /product="ISL3-like element IS1167A family transposase"
                     /protein_id="WP_000436237.1"
                     /transl_table=11
                     /translation="MEQLHFITKLLDIKDPNIKILDIINMDTHKEIIAKLDYEAPSCPD
                     CGSLMKKYDFQKPSKIPYLETTGMPSRILLRKRRFKCYHCSKMMVAETPLVKKNHQIPR
                     IINQKIAQKLIEKISMTDIAHQLAISTSTVIRKLNDFHFEHDFSRLPKIMSWDEYAFTK
                     GKMSFIAQDFDNLNIITVLEGRTQAVIRNHFLRYDRAVRCQVKIITMDMFSPYYDLAKQ
                     LFPCAKIVLDRFHIIQHLSRAMSRFRVQIMNQFERKSHEYKAIKRYWKLIQQDSRKLSD
                     KRFYRPTFRMHLTNKEILDKILSYSEDLKHHYQIYQLLLFHFQNKDPEKFFGLIEDNLK
                     QVHPIFQTVFKTFLKNKEKIVNALQLPYSNAKLEATNNLIKLIKRNAFGFRNFENFKKR
                     IFIALNIKKERTKFVLSRA"
     gene            complement(2717..3349)
                     /locus_tag="A1T31_RS01110"
                     /old_locus_tag="ERS367508_00212"
     CDS             complement(2717..3349)
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004260353.1"
                     /locus_tag="A1T31_RS01110"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS367508_00212"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_000571422.1"
                     /transl_table=11
                     /translation="MIELKQVSKSFGERELFSNLSMTFEAGKVYALIGSSGSGKTTLMN
                     MIGKLEPYDGTIFYRGKDLANYKSSDFFRHELGYLFQNFGLIENQSIEENLKLGLIGQK
                     LSRSEQRLRQKQALEQVGLVYLDLDKRIFELSGGESQRVALAKIILKNPPFILADEPTA
                     SIDPATSQLIMEILLSLRDDNRLIIIATHNPAIWEMADEVFTMDHLK"
     gene            complement(3351..4118)
                     /locus_tag="A1T31_RS01115"
                     /old_locus_tag="ERS367508_00213"
     CDS             complement(3351..4118)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012677041.1"
                     /locus_tag="A1T31_RS01115"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS367508_00213"
                     /product="DUF1430 domain-containing protein"
                     /protein_id="WP_000078816.1"
                     /transl_table=11
                     /translation="MSQKMNHLDVGEFVLLLPEHLRSEEEHYKSVFEDDLTSRISSQDE
                     RQQMTATVGYLESGQDRFVYNTTPISYQQFLKDPIIIVITPQSTGPQSILFWIDAVQNY
                     VLFNQLSDAQELIQRQGIENWVSEMQTGYHNYITLLDNIQRERWVMLAGAVLGIATSIL
                     LFNTMNRLYFEEFRRAIFIKRIAGLRFLEIHRTYLFAQLGVFLLGFVASVFLQVEIGVA
                     FLVLLLFTGLSLLQLHVQMQKENKMSMLVLKGG"
     gene            complement(4169..5908)
                     /locus_tag="A1T31_RS01120"
                     /old_locus_tag="ERS367508_00214"
     CDS             complement(4169..5908)
                     /EC_number="3.4.-.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S8"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1075: alkaline serine protease, subtilase family"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000699970.1"
                     /locus_tag="A1T31_RS01120"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS367508_00214"
                     /product="S8 family peptidase"
                     /protein_id="WP_000699969.1"
                     /sec_met_domain="Peptidase_S8 (E-value: 3.9e-38, bitscore:
                     125.4, seeds: 43, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIMKKKYWTLAILFFCLFNNSVTAQEIPKNLDGNITHTQTSESF
                     SESDEKQVDYSNKNQEEVDQNKFRIQIDKTELFVTTDKHLEKNCCKLELEPQINNDIVN
                     SESNNLLGEDNLDNKIKENVSHLDNRGGNIEHDKDNLESSIVRKYEWDIDKVTGGGESY
                     KLYSKSNSKVSIAILDSGVDLQNTGLLKNLSNHSKNYVPNKGYLGKEEGEEGIISDIQD
                     RLGHGTAVVAQIVGDDNINGVNPHVNINVYRIFGKSSASPDWIVKAIFDAVDDGNDIIN
                     LSTGQYLMIDGEYEDGTNDFETFLKYKKAIDYANQKGVIIVAALGNDSLNVSNQSDLLK
                     LISSRKKVRKPGLVVDVPSYFSSTISVGGIDRLGNLSDFSNKGDSDAIYAPAGSTLSLS
                     ELGLNNFINAEKYKEDWIFSATLGGYTYLYGNSFAAPKVSGAIAMIIDKYKLKDQPYNY
                     MFVKKILEETLPVKNGIKVLNIPNVLRYDLNMLQLEYKNEQSWDSFIDNVNLIELEERI
                     QTTIGIKQINTHNIITIAREGYSQNYLPNTSENTYNSLQVSLVGVLLLFISMVNILWAK
                     KSK"
     gene            complement(5932..8040)
                     /locus_tag="A1T31_RS01125"
                     /old_locus_tag="ERS367508_00215"
     CDS             complement(5932..8040)
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000701297.1"
                     /locus_tag="A1T31_RS01125"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS367508_00215"
                     /product="peptidase domain-containing ABC transporter"
                     /protein_id="WP_000701298.1"
                     /sec_met_domain="Peptidase_C39 (E-value: 6.1e-38, bitscore:
                     123.7, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIPMIYQMENSECGLACCAMILNYFKYEISLNELREIYPSSRSG
                     YSLLSISKVLGDFNISSHAFKASVRDLKPLSFPLICFWESSHFIILEKISKNKFYILDP
                     AKGRQRMSISEFERHYSNIILTFKKLDSFMSRKDNKKSPVLKYFFKYRNKLGILFFVTA
                     LLYVIQSLVPIANRYIIDTNFKDDSYSSRMLFTILFIFTVSFSLMYLLRQIYVASLKYI
                     MDKEISYDFMKHLIYLPYSFYEKRTLGDILFRANSIVYIREILSNNFIAAILDLLMIVV
                     YAVVLFSFSKYMVIFLISLSLALSIVMYPIIKISKNLIDKNIKEKVNVQNITSEVISKN
                     SDIKLTGEEEFWINKWDNFNTKQLIIGRKLDIHLSIVSSITNVLQIILPVLTLIVGVNI
                     KTFEQLTLGQIVAISTVSPYFISPIISLSDNYIQLMLLKGYFLRIEDVFNTKSELIPER
                     VSQDIKFDKKIELKDIWYKYGLFDDYVLKGINVTIKKGETVAIVGESGSGKSTLAKILL
                     GLLEPNIGSIEVDGVEKEEIGQTLYRKIFGAVLQNSTLSYGTLRENLTFGHFVSDEELM
                     TNLNSIGLSNVVKSLPLGLETIIAEEGNNFSGGQQQMILLARCLLSKPSVVVLDEATSS
                     LDNLSQQITTSYLSEIGTTKILIAHRLDTIKSADKILVMHNGEIVEIGTHRELLELGGI
                     YKQLYSNN"
     gene            complement(8037..8966)
                     /locus_tag="A1T31_RS01130"
                     /old_locus_tag="ERS367508_00216"
     CDS             complement(8037..8966)
                     /EC_number="3.4.24.-"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0004222 - metalloendopeptidase activity
                     [Evidence IEA]"
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000912951.1"
                     /locus_tag="A1T31_RS01130"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS367508_00216"
                     /product="M50 family metallopeptidase"
                     /protein_id="WP_000912954.1"
                     /transl_table=11
                     /translation="MLKILNNSVIYLCLIPLLFLLLIIFPNDSLIYYFRLILISLISIT
                     LHELGHFLVGRCLSYKLEMLATPFFFYFRKKIYFKFPVLLAFGYCQMSNRNITNEKNSD
                     RNLVFYFFGGGGANLIVAILALLGFVPYASEFFILNIILFLVTVCLPIDGTDGNAIREI
                     VLYSKDSKTYQRFFANSLYNNPYITIDDFAKLTSKEKSFFSKFEKCLINLYFEVKGEGS
                     AFTIANHEVFDSNIQENIIHEYYKLLHKSSDWIIPQNLSLEEVVFTLSNYIYSKNNKYL
                     EKIKYLKKLVDFRQEEIIDFILNKEEVL"
     gene            complement(8947..9651)
                     /locus_tag="A1T31_RS01135"
                     /old_locus_tag="ERS367508_00217"
     CDS             complement(8947..9651)
                     /GO_function="GO:0009055 - electron transfer activity
                     [Evidence IEA]"
                     /GO_function="GO:0010181 - FMN binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001033172.1"
                     /locus_tag="A1T31_RS01135"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS367508_00217"
                     /product="flavodoxin family protein"
                     /protein_id="WP_001033170.1"
                     /transl_table=11
                     /translation="MNKIFIYAGVRNHNSKTLEYTKRLSSIISSRNNVDISFRTPFNSE
                     LEISNSDSEELFKKGIDRQSNADDGGVIKKELLESDIIIISSPVYLQNVSVDTKNFIER
                     IGGWSHLFRLAGKFVVTLDVAESNGSDNVSEYLRDIFSYMGGQILHQVSITNSLKDIAE
                     AQLMEATYKIEDVLEGKIKYKTTDYQERAYQTLKLILENYDSEHFEKMYWEKKRLFEAN
                     SLEEWYYVENIK"
     gene            complement(10001..12991)
                     /locus_tag="A1T31_RS01140"
                     /old_locus_tag="ERS367508_00218"
     CDS             complement(10001..12991)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: DUF4135"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1070: lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000875571.1"
                     /locus_tag="A1T31_RS01140"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS367508_00218"
                     /product="type 2 lanthipeptide synthetase LanM family
                     protein"
                     /protein_id="WP_000875571.1"
                     /sec_met_domain="DUF4135 (E-value: 5.5e-91, bitscore:
                     299.5, seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 5.7e-52, bitscore:
                     170.6, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKYKIKNVHKTLFIKERYQILSERNDNSLNNFSLNNWRSTMSIIS
                     EKTFEEMLKLNNYNKKIFSNTVNYDYTEEQIRLYSEYAKNSEWYKFAEGSFEIFRKHPQ
                     RINFKKDFSRILEPFIINLLKLINNYLENKEYEWIDKNGNIFSSLVFYLEDLIYPWIVK
                     PLVLEINSLREKGLLEGESEQQRYKYFITLFDKEENILNFYNKYPVLLRQISESCLRFY
                     TYFIEILSNLENDFSVLEEELGLRGKLNDIKFGKGDTHSQGKTVLILFFDDAKIVYKPK
                     NLIINNSLNTIAEYIRKVDEKIRIRIPRTIAYSDHSYEEFIDYLPLEQKKKLPEYYYNF
                     GVLLAFIYLFNGSDIHFENLISYGDMPVIIDFETMLQQPLFDDKTGQSLLDTLFHRVTR
                     TLLLPTEGVKREDGLDVEMSALTGNFKKDAFNGQVLINLNTDKVKFDIGKIDFEGGKNL
                     PVRDGDIEFDKYIKDFKKGFRDFYLIFEELNKTEEFKMLLKANLYGLKTRVLFRDTNSY
                     ASVLSFLYHPDFYEEMLDREKALENLWSNKFSNQGIVASECEQMRLLDIPIFYTDTNIN
                     EIYDDFGNHFISLHQFSGYDYFMKYLPNNNLENLEKQLDIIEIYFPSFDQRKKGYKLNL
                     SNRKKLPNESLVTILHNEVENIADSLVINNIYDEYPIWSIPVNFKGSKWCLEQTGNDMY
                     RGRAGILLFMYYVKLLKDKSSYTQLYNKMLSAIPPSVSLSKTTFGLTGDIGYFIVLSII
                     EDYDTNTLACLNYIKSVLTELEKTDFASVSNKSDYINGLLPLINTLVRYYRRGIEKERV
                     LRLVLSLGDTLYNDVSERDNSNFGYSFGHGLSGVIFTLKNIYKVTRLKKYKELILQLVP
                     REKIKIHSLKWCSGEFGTLVNHPQSVPEGIVASLDNDTFCHGSMAIINFYIDYMKEMDT
                     SMELESLLCSVVMNKSKEGEYRIVQTSNFPDFSLYTGVTGIAYTFLRYIALNQNDKKIV
                     IPSLLEI"
     gene            complement(13107..13295)
                     /gene="pneA2"
                     /locus_tag="A1T31_RS01145"
                     /old_locus_tag="ERS367508_00219"
     CDS             complement(13107..13295)
                     /codon_start=1
                     /gene="pneA2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000786759.1"
                     /locus_tag="A1T31_RS01145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS367508_00219"
                     /product="two-peptide bacteriocin subunit PneA2"
                     /protein_id="WP_000786759.1"
                     /transl_table=11
                     /translation="MKNDFVIGKSLKELSLEEMQLVYGGTDGADPRSTIICSATLSFIA
                     SYLGSAQTRCGKDNKKK"
     CDS_motif       complement(13221..13295)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MKNDFVIGKSLKELSLEEMQLVYGG"
                     /locus_tag="A1T31_RS01145_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(13107..13220)
                     /prepeptide="core"
                     /locus_tag="A1T31_RS01145_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-1.30"
                     /molecular_weight="3743.2"
                     /monoisotopic_mass="3741.0"
                     /core_sequence="TDGADPRSTIICSATLSFIASYLGSAQTRCGKDNKKK"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MKNDFVIGKSLKELSLEEMQLVYGG"
                     /leader_location="[13220:13295](-)"
                     /alternative_weights="3761.2"
                     /alternative_weights="3779.2"
                     /alternative_weights="3797.3"
                     /alternative_weights="3815.3"
                     /alternative_weights="3833.3"
                     /alternative_weights="3851.3"
                     /alternative_weights="3869.3"
     gene            complement(13302..13526)
                     /gene="pneA1"
                     /locus_tag="A1T31_RS01150"
                     /old_locus_tag="ERS367508_00220"
     CDS             complement(13302..13526)
                     /codon_start=1
                     /gene="pneA1"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000181087.1"
                     /locus_tag="A1T31_RS01150"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS367508_00220"
                     /product="two-peptide bacteriocin subunit PneA1"
                     /protein_id="WP_000181087.1"
                     /transl_table=11
                     /translation="MTNFNSNEKFCGKSLKSLSADEMSLIYGASDGAEPRWTPTPIILK
                     SAAASSKVCISAAVSGIGGLVSYNNDCLG"
     CDS_motif       complement(13440..13526)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MTNFNSNEKFCGKSLKSLSADEMSLIYGA"
                     /locus_tag="A1T31_RS01150_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(13302..13439)
                     /prepeptide="core"
                     /locus_tag="A1T31_RS01150_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-0.40"
                     /molecular_weight="4315.8"
                     /monoisotopic_mass="4313.2"
                     /core_sequence="SDGAEPRWTPTPIILKSAAASSKVCISAAVSGIGGLVSYNNDC
                     LG"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MTNFNSNEKFCGKSLKSLSADEMSLIYGA"
                     /leader_location="[13439:13526](-)"
                     /alternative_weights="4333.9"
                     /alternative_weights="4351.9"
                     /alternative_weights="4369.9"
                     /alternative_weights="4387.9"
                     /alternative_weights="4405.9"
                     /alternative_weights="4424.0"
                     /alternative_weights="4442.0"
     gene            complement(13629..13799)
                     /locus_tag="A1T31_RS13485"
                     /old_locus_tag="ERS367508_00221"
     CDS             complement(13629..13799)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001227862.1"
                     /locus_tag="A1T31_RS13485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS367508_00221"
                     /product="PhrA family quorum-sensing system peptide"
                     /protein_id="WP_001227862.1"
                     /transl_table=11
                     /translation="MRKKRGIKKLVTFALLGVFMFSNTIPYQQFIQKNKQLEIRVQSQK
                     KSNGLDVGKAD"
     misc_feature    13782..13797
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: medium, score: 24.81"
                     /tool="antismash"
     gene            13993..14856
                     /locus_tag="A1T31_RS01160"
                     /old_locus_tag="ERS367508_00222"
     CDS             13993..14856
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001093609.1"
                     /locus_tag="A1T31_RS01160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS367508_00222"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_001093641.1"
                     /transl_table=11
                     /translation="MNTLAEKFRLKRKELRLSQQTLAEGICEQSQISKIERGHFIPSAD
                     LLFKLSQRLEVPLDYFFNEQIEVKSNLSNFKHLSARLLDDRNYDDLEYLYKIEVERSTF
                     LTLEDRTYLEWIKSIIDFYQYDSKCEAISSLENILLKVSSNTLIYLKALNTLSNFYSLV
                     GREQEYEANYSHLIELYQTKNLDHQEFLFGYIRVRYNYAHYLVSKEKYNEAIQEALETI
                     ELCKQRQTSYQLAPLLILVGNAGAKFLDREQVKNYYIEARELCKIYNNPLMLMKIENYL
                     KELDTV"
     misc_feature    14893..14910
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 22.23"
                     /tool="antismash"
     misc_feature    14956..14969
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 19.16"
                     /tool="antismash"
     gene            15239..15859
                     /locus_tag="A1T31_RS01165"
                     /old_locus_tag="ERS367508_00223"
     CDS             15239..15859
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000839915.1"
                     /locus_tag="A1T31_RS01165"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS367508_00223"
                     /product="hypothetical protein"
                     /protein_id="WP_000839908.1"
                     /transl_table=11
                     /translation="MKSMRILFLLALIQISLSSCFLWKECILSFKQSTAFFIGSMVFVS
                     GICAGVNYLYTRKQEVHSVLASKKSVKLFYSMLLLINLLGAVLVLSDNLFIKNTLQQEL
                     VDFLLPSFFFLFGLDLLIFLPLKKYVRDFLAMLDRKKTVLVTILATLLFLRNPMTIVSL
                     LIYIGLGLFFAAYLVPNSVKKEVSFYGHIFRDLVLVIVTLIFF"
     gene            15945..16388
                     /gene="tsaE"
                     /locus_tag="A1T31_RS01170"
                     /old_locus_tag="ERS367508_00224"
     CDS             15945..16388
                     /GO_process="GO:0002949 - tRNA threonylcarbamoyladenosine
                     modification [Evidence IEA]"
                     /codon_start=1
                     /gene="tsaE"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000288243.1"
                     /locus_tag="A1T31_RS01170"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS367508_00224"
                     /product="tRNA
                     (adenosine(37)-N6)-threonylcarbamoyltransferase complex
                     ATPase subunit type 1 TsaE"
                     /protein_id="WP_000288232.1"
                     /transl_table=11
                     /translation="MYTKNEEELQALGERLGHLLAKNDVLILTGELGAGKTTFTKGLAK
                     GLQISQMIKSPTYTIVREYEGRLPLYHLDVYRIEGDADSIDLDEFIFGGGVTVIEWGNL
                     LGDALPDAYLELEILKEADGRRLNFQAKGLRAEKLLEELQYGV"
     gene            16378..16896
                     /locus_tag="A1T31_RS01175"
                     /old_locus_tag="ERS367508_00225"
     CDS             16378..16896
                     /EC_number="2.3.-.-"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000455540.1"
                     /locus_tag="A1T31_RS01175"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS367508_00225"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_000455537.1"
                     /transl_table=11
                     /translation="MEYELLIREAEPKDAAELVAFLNRVSLETDFTSLDGDGILLTSEE
                     MEIFLNKQASSDNQITLLAFLNGKIAGIVNITADQRKRVRHIGDLFIVIGKRYWNNGLG
                     SLLLEEAIEWAQASGILRRLQLTVQTRNQAAVHLYQKHGFVIEGSQERGAYIEEGKFID
                     VYLMGKLIG"
     gene            16904..17920
                     /gene="brpA"
                     /locus_tag="A1T31_RS01180"
                     /old_locus_tag="ERS367508_00226"
     CDS             16904..17920
                     /codon_start=1
                     /gene="brpA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000239264.1"
                     /locus_tag="A1T31_RS01180"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS367508_00226"
                     /product="biofilm formation/cell division transcriptional
                     regulator BrpA"
                     /protein_id="WP_000239284.1"
                     /transl_table=11
                     /translation="MVKKIIGMVLALLSVTVVGVGVFAYTIYQQGTETLAKTYKKIGEE
                     TKVIEATEPLTILLMGVDTGNVERTETWVGRSDSMILMTVNPKTKKTTMMSLERDILTR
                     IESGNGQAHEAKLNSAYADGGAELAIETIQKMMNIHIDRYVMVNMRGLQKLVDAVGGIT
                     VNNILGFPISISDQEEFNTISIGVGEQHIGGEEALVYARMRYQDPEGDYGRQKRQREVI
                     QKVMEKALSLNSVGHYQEILKALSDNMQTNIDLSAKSIPNLLGYKDSFKTIETQQLQGE
                     GEILQGVSYQIVSRAHMLEMQNILRRSLGQEEVTQLETNAVLFEDLFGRAPVGDEDN"
     misc_feature    17965..17978
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: medium, score: 23.52"
                     /tool="antismash"
     misc_feature    17966..17979
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: medium, score: 23.7"
                     /tool="antismash"
     gene            18005..19261
                     /locus_tag="A1T31_RS01185"
                     /old_locus_tag="ERS367508_00227"
     CDS             18005..19261
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000642700.1"
                     /locus_tag="A1T31_RS01185"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS367508_00227"
                     /product="competence/damage-inducible protein A"
                     /protein_id="WP_000642705.1"
                     /transl_table=11
                     /translation="MKAEIIAVGTEILTGQIVNTNAQFLSEKLAEIGVDVYFQTAVGDN
                     EVRLLSLLEIASQRSSLVILTGGLGPTEDDLTKQTLAKFLGKALVFDPQAQEKLDIFFA
                     LRPDYARTPNNERQAQIVEGAIPLPNETGLAVGGKLEVDGVTYVVLPGPPSELKPMVLN
                     QLLPKLMTGSKLYSRVLRFFGIGESQLVTILADLIDNQIDPTLAPYAKTGEVTLRLSTK
                     ASSQEEANQALDILENQILDCQTFEGISLRDFCYGYGEETSLASIVVEELKRQGKTIAA
                     AESLTAGLFQATVANFSGASSIFKGGFVTYSLEEKSRMLDIPAKNLEEHGVVSEFTAQK
                     MAEQARSKTQSDFGISLTGVAGPDSLEGHPVGTVFIGLAQEQGTEVIKVNIGGRSRADV
                     RHIAVMHAFNLVRKALLSD"
     gene            19316..20482
                     /gene="recA"
                     /locus_tag="A1T31_RS01190"
                     /old_locus_tag="ERS367508_00228"
     CDS             19316..20482
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003697 - single-stranded DNA binding
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0008094 - ATP-dependent activity, acting
                     on DNA [Evidence IEA]"
                     /GO_process="GO:0006281 - DNA repair [Evidence IEA]"
                     /codon_start=1
                     /gene="recA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397020.1"
                     /locus_tag="A1T31_RS01190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS367508_00228"
                     /product="recombinase RecA"
                     /protein_id="WP_001085462.1"
                     /transl_table=11
                     /translation="MAKKPKKLEEISKKFGAEREKALNDALKLIEKDFGKGSIMRLGER
                     AEQKVQVMSSGSLALDIALGSGGYPKGRIIEIYGPESSGKTTVALHAVAQAQKEGGIAA
                     FIDAEHALDPAYAAALGVNIDELLLSQPDSGEQGLEIAGKLIDSGAVDLVVVDSVAALV
                     PRAEIDGDIGDSHVGLQARMMSQAMRKLGASINKTKTIAIFINQLREKVGVMFGNPETT
                     PGGRALKFYASVRLDVRGNTQIKGTGDQKETNVGKETKIKVVKNKVAPPFKEAVVEIMY
                     GEGISKTGELLKIASDLDIIKKAGAWYSYKDEKIGQGSENAKKYLAEHPEIFDEIDKQV
                     RSKFGLIDGEEVSEQDTENKKDEPKKEEAVNEEVPLDLGDELEIEIEE"
     gene            20789..22159
                     /locus_tag="A1T31_RS01195"
                     /old_locus_tag="ERS367508_00229"
     CDS             20789..22159
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1086: MATE efflux
                     family protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001036275.1"
                     /locus_tag="A1T31_RS01195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS367508_00229"
                     /product="MATE family efflux transporter"
                     /protein_id="WP_001036270.1"
                     /transl_table=11
                     /translation="MNKKRTVDLIHGPILPSLLSFTFPILLSNIFQQLYNTADVLIVGR
                     FLGQESLAAVGATTAIFDLIVGFTLGVGNGMGIVIARYYGARNFTKIKEAVAATWILGA
                     LLSILVMLLGFLGLYPLLQYLDTPAEILPQSYQYISMIVTCVGVSFAYNLFAGLLRSIG
                     DSLAALGFLIFSALVNVVLDLYFITQLHLGVQSAGLATIISQGLSAVLCFYYIRKSVPE
                     LLPQFKHFKWDKSLYADLLEQGLAMGLMSSIVSIGSVILQFSVNTFGAVIISAQTAARR
                     IMTFALLPMTAISASMTTFASQNLGAKRPDRIVQGLRIGSRLSISWAVFVCIFLFFASP
                     ALVSFLASSTDGYLIENGSLYLQISSAFYPILSLLLIYRNCLQGLGQKILPLVSSFIEL
                     IGKIVFVVLIIPWAGYKGVILCEPLIWVAMTVQLYFSLFRHPLIKEGKAILATKVQS"
     misc_feature    22702..22716
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: weak, score: 20.04"
                     /tool="antismash"
ORIGIN
        1 tgtaatgaaa tgctgatgta actgttttag gaacaataaa acgcataata tcaaggtttt
       61 tgcaccttac attatgcgtt tttgtgattt taagacttgt tagctgattt tttacaatcc
      121 tgcgaaatct ttgatttctt gtgctgacat tgaagagtcg caacggacgt tgatttgtcc
      181 atctgtaata tgaataaaac ctggtacagt tgggattcca tagcgtgagc ggaatgcttg
      241 caaatcattg agttggcttg gttcttcact attgatgaag taaatgtgag ctttggtttc
      301 agctacgaca cctgacaatg tatctgcaaa tttacggcag taagggcaag ttttgcgacc
      361 gataaagaag gttgcagttt cttttttatc aagagcttct tgcgcacgca caactgtagt
      421 gacttcaagg tctttgatgt tatctaaaaa ttgttccatg agattacctc gctttcattg
      481 ataagtctag tatgccataa agtttctaaa attgcttaga tttgatacga aaaaagatga
      541 ggttggttgg tctcatcttt taggctctat aatatttgta gtgggtaaat cccctataga
      601 tattatggag actattttgt gtagaaaaaa agtcccatat gacctataat gaaaagcgac
      661 aaaacaactc attagaaaga ttcatatgga acaattacat tttatcacaa aactgctcga
      721 tattaaagac ccaaacatca agattctaga tatcatcaat atggataccc acaaagaaat
      781 tatcgctaag ctggattatg aggctccatc ttgccctgat tgtggaagtc taatgaagaa
      841 atatgacttt caaaaaccgt ctaagatccc ttacctcgaa acaactggta tgccttctag
      901 aattctcctt agaaaacgcc gtttcaagtg ctatcactgt tcaaaaatga tggttgctga
      961 gactcccctg gtaaagaaaa atcaccaaat ccctcgtatc atcaaccaaa aaattgctca
     1021 aaagttaatt gaaaaaattt ctatgactga tattgcccat cagctggcca tttcaacttc
     1081 aactgtcatt cgcaagctca atgactttca ctttgagcat gatttttctc ggcttccaaa
     1141 gattatgtct tgggatgagt atgccttcac taagggaaag atgagtttca ttgcgcaaga
     1201 ttttgataat cttaatatta tcactgttct tgaaggcaga acacaagctg tcatccgaaa
     1261 tcactttctt cgctacgata gagccgttcg ttgtcaagtg aaaatcatta cgatggatat
     1321 gtttagtcct tactatgact tggctaaaca gctttttccg tgtgctaaaa tcgttctaga
     1381 tcgtttccat attatccaac atctcagccg tgccatgagt cgttttcgtg ttcaaattat
     1441 gaatcagttt gaacgaaaat ctcatgaata caaggctatc aagcgttact ggaaactcat
     1501 ccaacaggat agtcgtaaac tcagcgataa acgtttttat cgccctactt ttcgcatgca
     1561 cttaacaaat aaagaaattc ttgacaagat tttaagctat tcagaagact tgaaacacca
     1621 ctatcagatc tatcaactct tactttttca ctttcagaac aaagaccctg agaaattttt
     1681 cggactcatt gaggacaatc tgaagcaggt tcatcctatt tttcagactg tctttaaaac
     1741 ctttctaaag aacaaagaga aaatcgtcaa cgcccttcaa ctaccctatt caaacgccaa
     1801 attggaagcg accaataatc tcatcaaact tatcaaacgc aatgcctttg gttttcgaaa
     1861 ctttgaaaac ttcaaaaaac ggatttttat cgctctgaat atcaaaaaag aaaggacaaa
     1921 atttgtcctt tctcgagctt agcttttttt caacccacta cagttgacaa agagccaaaa
     1981 aactccaaac gcgatacaat aaaggtgttc aatccaattg taaagcgaaa ggagaaaaat
     2041 atggcacaaa aggttctttt atcctgttct tgtttcaatt gactatattt ctatactttt
     2101 tcttcctttc tctgtgaaaa tcgcaagttt ttcccacctt ttctcaatac tgaaacaaca
     2161 tctttccaga acttcaataa tttctttttg tgttaaatca ttatttaact aaatctttgg
     2221 aggcaatacg ttttcaaagc tactttttta ccataggttt tgagccttca acacagatta
     2281 ctaagccaaa aatgctctaa atttttgaaa ttctaacaaa ttccactcaa ctttatcatc
     2341 atctttgact ttcacaatat cttcctcaaa ataacatgga ataaagatag ttttctttta
     2401 aaacggttgt aggaggaaaa tctctcctac actattattg attctgagag aaaattgcaa
     2461 aatatcatct accaaacttt caattattaa gattttttgc agtttatctg aattagaatc
     2521 gcaaggcttc tcaataatat aattgtcgaa ttttttcatt ctaacttcct ctccattatt
     2581 tcttccttta tcaagaaaaa gttacctcaa tattaataaa gtacaattct aaattaagta
     2641 caattctaaa ttaactccaa ttcttgattc atgataatat ttcagtaact catcgtgcaa
     2701 ttaaaaacaa ggatttttat ttcagatgat ccatcgtgaa cacttcatca gccatctccc
     2761 aaattgccgg attatgtgtt gcgataatga ttagcctatt atcatctcga agagatagca
     2821 aaatctccat aatcaactga gaggttgctg ggtctattga agctgttggc tcatctgcca
     2881 gaataaaggg tggattcttt aagataattt ttgccaaggc aacccgttgc gattctccgc
     2941 ccgataactc aaagatgcgc ttatctaggt caagataaac caggccgacc tgttctaaag
     3001 cctgcttctg cctcaaccgc tgttccgacc gactcaactt ttgaccaatg agacctagct
     3061 taaggttttc ttcaatactt tggttttcaa ttaagccaaa gttctggaag aggtagccca
     3121 attcgtgacg gaaaaaatca cttgatttat aattggccaa gtctttacct cggtaaaaaa
     3181 tcgtcccatc ataaggttct aatttcccaa tcatgttcat caaggttgtt tttccgctac
     3241 cacttgaacc aattaaggca tagacttttc cagcctcaaa tgtcattgaa agattcgaaa
     3301 ataactctcg ttctccaaaa gatttactca cctgtttaag ttcaatcata ttaacctccc
     3361 ttcaaaacaa gcatggacat cttgttttct ttctgcattt ggacatgtaa ctgtaaaaga
     3421 gatagaccag taaagagtaa caagactaag aaagcaactc ctatctctac ctgaagaaat
     3481 acactcgcaa caaatcccag taaaaacaca cccagttgag caaagagata agtgcgatgg
     3541 atttctaaga acctgagacc tgcaatgcgt ttgataaaaa tggcacgtct aaattcttca
     3601 aagtagagcc tattcatagt gttaaacaac aagattgaag ttgcaatccc aagcacagct
     3661 cctgctagca ttacccaacg ttccctctgg atattatcca ataatgtgat gtagttgtgg
     3721 taacctgttt gcatttctga gacccaattt tcaatgcctt gtctctggat aagctcctgg
     3781 gcatcagaca attgattaaa gagaacgtag ttctgtactg cgtctatcca aaacaaaatg
     3841 gactgtggac cagttgattg gggtgttata acaatgatga ttggatcttt caaaaactgc
     3901 tggtaagaaa taggggtcgt attatacaca aaacgatcct gacctgattc taaataacct
     3961 accgtagcag tcatttgctg tcgttcatct tgactagata tgcgactggt taagtcgtct
     4021 tcaaaaacag atttataatg ttcttcctct gaacggaggt gttcaggcag caataagaca
     4081 aactccccta catcaaggtg attcatcttt tgactcattt tagttgaact gtaggactta
     4141 ctttttcaga gggctccaaa ttttattttc atttactttt tttagcccat aaaatattta
     4201 ccatacttat aaaaagtagt aatactccaa ctaaactgac ttgtaatgaa ttatatgtat
     4261 tttctgaagt gttaggtaaa taattttgag agtacccttc tcgggcaata gtaataatat
     4321 tgtgtgtgtt tatttgttta attccaatag tagtttgaat tctctcttcc aactcaatta
     4381 aattaacatt atctatgaaa ctatcccaac tttgttcatt tttatattct aattgtaaca
     4441 tattcaaatc atatctcaat acgtttggta tatttaacac ttttatacca ttttttactg
     4501 gtaatgtttc ttccagaatt ttttttacaa acatataatt atagggctga tcttttaatt
     4561 tgtatttatc aataatcatt gcaatcgcac cagaaacttt aggagcagca aatgagtttc
     4621 cataaagata cgtatatcct cctagtgttg ccgaaaaaat ccaatcttct ttatattttt
     4681 ctgcattaat aaagttatta agtcctaatt ctgaaagaga taatgttgag cctgcaggcg
     4741 catatattgc atcagaatcc cctttattgc taaaatctga taaattacct aagcgatcta
     4801 tgcctccgac cgaaattgta gatgagaaat aacttggaac atcaactact aatcctggtt
     4861 ttcttacttt tttgcgtgaa ctaataagtt tcaataaatc tgactgattt gatacattta
     4921 gggagtcatt ccctaatgca gctactataa ttactccttt ttgattcgcg taatcaatag
     4981 cctttttata cttcaaaaat gtttcaaaat catttgttcc gtcctcatat tctccatcaa
     5041 tcattaaata ttgtccagta ctaagattga taatatcatt gccatcatct acagcatcaa
     5101 aaattgcttt tacaatccaa tctggactag ctgacgactt accaaatatt ctatagacgt
     5161 taatattaac gtgaggattt actccattaa tattgtcatc ccctacaatt tgagctacaa
     5221 cagccgtacc atgacctaat ctatcttgaa tatctgatat tattccttcc tctccctcct
     5281 cttttcctaa atatccttta ttggggacat agttttttga gtgatttgaa agatttttca
     5341 gtaatccagt attttgtaaa tcgactcctg aatctaaaat agcaattgaa actttagaat
     5401 tacttttaga atataattta taactttcgc ctccaccagt aactttatct atatcccatt
     5461 catattttct tacaatcgac gattctaagt tatctttgtc atgctctata tttcctcctc
     5521 tattatctag atgagaaaca ttttccttaa ttttattatc taaattatct tcgcctagta
     5581 aattattact ttcagagtta acaatatcgt tatttatttg tggttcaagt tccaatttac
     5641 aacagttttt ttctaaatgt ttatctgttg ttacaaataa ttctgtctta tcgatttgaa
     5701 tacgaaattt attttggtct acttcttctt gatttttatt agaatagtca acctgttttt
     5761 catcagattc agaaaaactt tcgctagtct gagtgtgagt tatattgcca tcaagatttt
     5821 taggtatttc ttgagcagta acagaattat tgaacaaaca aaagaataat atcgctaaag
     5881 tccaatattt ttttttcata atcttcataa atttaccctt ttaatcaaaa actaattatt
     5941 tgaatacaat tgcttataaa tgcctcctag ttcaagaagt tctctatggg tcccaatctc
     6001 tacaatttca ccattatgca ttactaagat cttatctgca gacttgatag tatctagtcg
     6061 atgggcaatt aaaatcttag tggtaccgat ttcacttaag taagaagttg taatttgttg
     6121 agataaatta tctaaactac ttgttgcttc gtccaaaaca actaccgaag gtttcgacaa
     6181 aagacaacga gctaaaagta tcatttgctg ctgccctcca gaaaagttat taccttcttc
     6241 agcgatgatt gtctctaatc caagaggtaa agatttaact acattgctaa gaccaattga
     6301 atttagattt gtcattaatt cttcatctga aacaaagtgt ccaaatgtca aattctctct
     6361 taaggtacca taacttaggg ttgaattttg taacactgct ccaaaaatct ttctatacaa
     6421 tgtttgacca atttcttctt tttctactcc atcaacttct attgaaccaa tattaggttc
     6481 taataaacct aataaaattt tagctaatgt actcttacct gaacctgatt ctccaacaat
     6541 agcaacagtt tctccttttt taatagtaac atttattcct ttcaaaacat aatcatcaaa
     6601 taatccatat ttataccaaa tatcttttaa ttctattttt ttatcaaatt ttatatcttg
     6661 actgactctt tctggaatta attcggattt agtattaaac acatcctcta ttcttaaaaa
     6721 atatcccttt aataacatta attgtatata gttatcactt aaagaaatta taggagaaat
     6781 aaagtatggt gagactgtac ttattgctac aatttgtcct aacgtcaatt gttcgaatgt
     6841 ttttatattt acacctacaa taagggtcaa aacagggaga ataatttgta aaacattcgt
     6901 tatactacta acaattgata aatgtatatc aagttttcga cctatgatga gctgttttgt
     6961 attaaaatta tcccatttgt taatccaaaa ttcctcttct ccagttagct taatatcact
     7021 atttttagaa attacttcgg aagtaatatt ttgaacatta accttttctt ttatattttt
     7081 atcaattaaa ttttttgaga tttttatgat tggatacatt acaatagata gagctagact
     7141 tagtgatatt aaaaagatta ccatgtactt agaaaagcta aataaaacca cagcataaac
     7201 cacaatcatt aacaaatcaa gtatagctgc tataaaatta tttgatagta tttctcttat
     7261 ataaacaata gagttagctc taaaaagtat atcccctaaa gtacgttttt cataaaaact
     7321 gtaaggtaaa tatatcaaat gtttcataaa atcatagcta atctctttat ccattatata
     7381 ttttaaggat gcaacatata tctgtcttaa taaatacatt agtgagaatg aaacagtaaa
     7441 tataaataat atagtaaata acattctaga cgaatacgaa tcgtccttga aattcgtgtc
     7501 aattatgtat ctattagcta taggtactaa tgattgtatt acatacaata atgctgttac
     7561 aaaaaataaa atccctagct tattcctata cttaaaaaaa tactttaaaa caggcgactt
     7621 cttattatct ttacgagaca taaagctatc taacttttta aatgttaaaa tgatatttga
     7681 ataatgcctt tcaaattcac ttattgacat tctctgcctg ccttttgcag gatctaaaat
     7741 ataaaacttg tttttactaa ttttttcaag aataataaaa tgagaactct cccagaagca
     7801 aatgagtggg aaactgagcg gttttaaatc tcttaccgaa gctttaaaag catgagaact
     7861 tatattaaaa tctcctaaaa ctttacttat agataggaga gaatatccag atctggatga
     7921 tgggtagatt tcacgtagtt catttaaaga aatctcatat ttaaaatagt tcaatatcat
     7981 ggcacagcat gctaatccac attctgaatt ttccatttga tatatcattg gaattttcac
     8041 aatacttcct ccttgttcaa aataaagtcg ataatttctt cttgtctaaa atctactaat
     8101 ttctttagat acttaatctt ttctaaatat ttattatttt tcgagtaaat atagtttgac
     8161 aaggtaaaaa caacttcttc taaagataag ttctgtggaa taatccaatc agaagattta
     8221 tgtagtaatt tatagtactc atggataata ttttcctgaa tatttgaatc aaaaacttca
     8281 tgattagcaa ttgtaaatgc tgacccttca cctttcactt caaagtaaag gtttatcaaa
     8341 catttttcaa attttgaaaa aaaagatttt tctttagagg ttaattttgc aaaatcgtcg
     8401 attgttatat aaggattatt atagagactg ttcgcaaaga atctctgata tgtttttgaa
     8461 tcttttgaat acaaaactat ctctctaata gcattgccat ctgttccatc aattggtaaa
     8521 cataccgtaa ctagaaaaag aattatattc aaaataaaaa attctgatgc gtacggcaca
     8581 aatcccaaaa gtgctaatat tgcgacaatt aggttagctc cacctccccc aaagaagtag
     8641 aacaccaaat tcctatcact atttttttca ttagtaatgt ttctattact catttgacaa
     8701 taaccgaatg ctaataacac tggaaatttg aaatatattt tttttctgaa atagaagaaa
     8761 aagggagtag caagcatctc tagtttataa gataaacatc ttcccactaa aaaatgacct
     8821 agttcatgta atgtaattga tattaacgaa attaaaatca atcgaaaata atagattaat
     8881 gaatcatttg gaaaaattat caataatagg aacaataacg gaatcaaaca taaatatatg
     8941 acagagttat ttaatatttt caacataata ccattcctct aaactattag cttcaaaaag
     9001 gcgttttttc tcccaataca tcttctcaaa atgttcggaa tcataatttt ctaaaattaa
     9061 ttttaatgtc tggtaagctc tttcttgata atccgttgtt ttgtacttaa ttttcccttc
     9121 aagtacatct tcaattttat aagttgcctc catcaactga gcctctgcaa tatctttgag
     9181 tgaattggta attgaaactt ggtgtaatat ctgtcctccc atatatgaaa atatatctct
     9241 aagatattct gacacattat cagagccgtt actctcagca acatctaatg ttacaacaaa
     9301 ctttccagct aatcgaaaaa gatggctcca ccccccaatc ctttcaataa agttttttgt
     9361 gtccacagat acgttttgta aatatacagg agaagagata attataatat cagactctaa
     9421 taactctttt tttataacac ctccatcatc agcattactt tgcctatcaa ttcctttctt
     9481 aaacaactct tctgaatcag aattagatat ttctagctct gaattgaaag gtgtcctgaa
     9541 agatatatca acattatttc tactagaaat gatacttgaa agtctcttag tatactctaa
     9601 agtcttagag ttatgatttc gcactcctgc atatataaat attttattca ttttaattca
     9661 tcctctcaat ttgaatttag tagatttttc aagatagtat ggtacaaaaa cagacttttg
     9721 ttgactcaca ttattacata tgttttgtat taaaccaaaa tcaatactat ttttggagta
     9781 attttgattt tagtttaaaa tcatttctat aacagtagca tatacctcaa gccgtttagc
     9841 aattagaata gaacttttct ttattatatt attatctcaa cgaaaagcta cactattaaa
     9901 aatattttat agaattacat attaaactag tcaatcttgg tatttttata ttgcttaatg
     9961 agtggacacc tctattttag aaacaaaact ataaattaag ctagatttca agtaatgagg
    10021 ggataactat ctttttgtca ttctgattca gtgcgatata ccttaaaaaa gtataagcaa
    10081 taccagtcac acctgtatac aaagaaaaat ctgggaaatt gcttgtttgg acgatacgat
    10141 actctccttc ttttgattta ttcattacaa cactacacaa taaagactcc aattccatac
    10201 tagtatccat ttctttcatg tagtcgatgt aaaaatttat tatggccata cttccatggc
    10261 aaaatgtatc attatctaaa ctagctacaa ttccctctgg aacactttgg ggatgattaa
    10321 ctaatgtccc aaattctcca ctacaccact tcaaagaatg aattttgatt ttctccctag
    10381 gaactagttg taaaattaat tctttatatt ttttaagtct tgtcacttta taaatatttt
    10441 ttaatgtaaa aattacacct gatagtccat ggccaaaact atatccaaaa ttactattat
    10501 ctctctcgct tacatcatta tatagcgtat cacctaaact taatactagc cttagaacac
    10561 gttccttctc tattcctctc ctataatatc ttaccagtgt attaattaaa ggtagaagac
    10621 cattaatata gtcagacttg tttgaaacac ttgcaaaatc agtcttttca agctcagtta
    10681 aaacactctt tatataattt aagcatgcga gagtatttgt atcgtaatcc tctataatgg
    10741 atagaacaat gaaatatcct atatccccag ttaaaccaaa tgtggtctta gataaagaaa
    10801 cagatggcgg aattgcagat aacattttat tgtacagttg agtatatgat gatttatctt
    10861 tcaataattt tacatagtac ataaacagta atattccagc tctaccccta tacatatcat
    10921 tacccgtttg ttcaagacac catttagaac ctttaaaatt aacaggtata ctccaaattg
    10981 gatattcgtc ataaatatta ttaataacca aagagtctgc aatattttct acttcattat
    11041 gcagaatagt aactaaactt tcatttggga gtttttttct attagataag tttaatttat
    11101 atcctttttt tcgctgatca aagcttggaa aataaatttc aatgatatca agttgctttt
    11161 ctaaattttc caaattatta ttaggtaaat atttcataaa atagtcatat ccagaaaatt
    11221 gatgtaggga aataaaatga tttccaaaat catcgtagat ttcattgata tttgtatctg
    11281 tataaaaaat cggaatatct aataacctca tttgttcaca ttcgcttgct acaatacctt
    11341 gattagaaaa cttattgctc cagagatttt ccaatgcttt ttctctatct aacatttctt
    11401 cataaaaatc aggatgatat aaaaaagata gtactgaagc atagctattt gtgtctctaa
    11461 aaagtaccct tgtctttaaa ccatacaagt ttgcttttaa tagcatttta aattcttctg
    11521 ttttatttaa ctcttcaaat atcagataaa aatccctaaa accttttttg aaatctttta
    11581 tatacttatc aaattctata tcaccatccc gaacaggcag gtttttccca ccttcaaaat
    11641 caattttccc aatatcaaac tttaccttat cagtatttaa attaattaaa acttgaccat
    11701 taaaagcatc cttcttaaaa tttcctgtaa gagcactcat ctcaacatca agaccatcct
    11761 ccctttttac tccctctgtt ggaagaagca aagttcgagt caccctgtga aacagggtat
    11821 ccagcaaact ctgaccagtt ttatcatcaa atagaggttg ctgtaacatt gtttcaaagt
    11881 ctattattac aggcatatct ccataggaaa ttaaattttc aaaatgtata tcactcccat
    11941 taaataaata tataaatgct aaaagcacac caaaattata ataatattca ggtaattttt
    12001 tcttttgctc tagaggtaga taatcaataa attcttcata gctgtgatcc gaataagcaa
    12061 tagttcgagg tattcttatc ctaatttttt catcaacctt tcggatatac tcagcaatag
    12121 tatttagtga gttattgatt attaaatttt taggcttgta aacaattttc gcgtcatcaa
    12181 agaagagtat caaaacagtt tttccttggc tgtgtgtatc accctttcca aattttatat
    12241 catttaattt cccccttagc cctaattctt cttctagcac actaaaatca ttttctaaat
    12301 ttgataaaat ttctataaaa taagtataga accgaagaca agactccgat atttgcctca
    12361 gtaaaacggg atatttgtta taaaaattta atatattctc ttccttgtca aacaatgtta
    12421 taaaatattt gtaccgttgc tgctccgatt ccccttcaag taaacctttt tcacgcaatg
    12481 aatttatctc taaaaccaaa ggtttaacaa tccaaggata gattaaatct tctaaataaa
    12541 atactagaga ggaaaaaata tttccattct tgtcaatcca ctcgtattct ttattctcta
    12601 gataattatt gattaattta agcaaattaa taataaaggg ttccaaaatt ctagaaaaat
    12661 ctttcttaaa attaattctt tggggatgtt ttctaaatat ttcaaatgaa ccctccgcaa
    12721 atttatacca ttccgaattt ttggcatatt ctgaatatag tcttatctgt tcctcggtat
    12781 aatcatagtt cacagtgtta gaaaatattt ttttattgta attatttaat ttcaacattt
    12841 cttcaaaagt tttttcagaa ataattgaca ttgtagaacg ccaattattt aatgaaaagt
    12901 tatttaagga attatcattt cgttcagata atatttgata tctttcctta ataaacaatg
    12961 ttttatgcac atttttaatt ttatatttca tttacttacc tcaaacctat acgacttact
    13021 attgttttaa aaaaaaacct ctctcaaaat tattagttac gagagaggaa aataaagagc
    13081 aacttttatt tttaaaattg aatattttat tttttcttgt tgtctttgcc acaacgagtc
    13141 tgagctgacc ccaaatatga tgcaataaaa cttaatgtag cagaacatat aattgttgat
    13201 ctagggtcag caccatctgt gccaccataa accaattgca tttcttcaag agataattct
    13261 ttcaaactct ttccgattac aaaatcattt ttcattttaa tttaccccaa acaatcatta
    13321 ttgtagctaa ctagcccccc aataccagaa acagctgcac taatgcatac tttcgagcta
    13381 gctgcagctg atttcaaaat aataggagta ggcgtccaac gtggctctgc accatcagat
    13441 gcaccataaa ttaaactcat ttcatcagca gacaatgatt ttaaactttt tccacaaaat
    13501 ttttcgtttg aattaaagtt ggtcataagt aataactcct ccttataaaa agttaaataa
    13561 gttgctctat atttttcgtt ttttcagata aattataatt ctctcattct cgtgcaaaat
    13621 atcgggtttt aatccgcctt cccaacatca agaccattgg acttcttttg cgattgcact
    13681 cgaatctcca attgtttatt cttctgaata aactgttggt aaggaattgt attactaaac
    13741 ataaaaacac ctagcaatgc aaatgtaact aattttttaa ttccacgttt ttttctcatg
    13801 caatgaaacc cctttctttt tccttgtttt tattctaaca gatatatttt atttagtcaa
    13861 gtatttttat gtaattttta actttttttt ttttgtttat taccataaag aattatttat
    13921 tcctttaact tgctattttg aactaaaaac tttataatga aattaagcaa ataggaaggt
    13981 ttattatctt taatgaatac actcgcagag aaattcagat tgaaaagaaa agagttgaga
    14041 ctctcccaac aaactcttgc agaaggaatt tgtgaacaaa gccagattag taaaattgaa
    14101 agaggtcatt ttattccctc cgcagacttg ttattcaaac tctctcaacg acttgaagtc
    14161 cctttggatt actttttcaa tgaacaaatc gaagttaagt ctaacctctc taatttcaaa
    14221 catctatctg ctcgcctatt agatgacaga aattatgacg atttagaata tctttataaa
    14281 atagaggtag aacgaagcac ttttctaaca ttagaagacc gaacttacct tgaatggatt
    14341 aaatctataa ttgacttcta tcaatatgac agtaagtgtg aggcaatttc gtcattggaa
    14401 aatatattat taaaagtctc ttcaaatact ctgatttatt taaaggcgtt gaatactcta
    14461 tctaatttct attccttagt gggtcgtgaa caagaatatg aggcaaacta ctctcattta
    14521 atagagttgt atcagacaaa aaatttggac catcaagagt ttttatttgg ctacatcaga
    14581 gttcgttaca actacgctca ctacctagta tcaaaggaaa aatataatga agccatccaa
    14641 gaagctcttg aaacgattga actctgtaaa caaagacaga caagctacca attggctcct
    14701 ctacttattc ttgtaggaaa tgctggagcc aaatttctag acagagaaca agtcaaaaat
    14761 tattatatag aagcaagaga gttatgtaag atttataaca atcctttaat gttgatgaag
    14821 atagaaaatt atttgaagga actagatact gtttagttaa tcttgacatt atagtttttc
    14881 tgaaacgtta aataacctgt aaggctgata gttagattaa tactatcagc cttataatta
    14941 tgtgactctg agtccgtctc gctccgtgag gtgcgagaca aaacaaccac ccgtttgacg
    15001 gattttcatg atttcaaatt tatattcttc gaaaatctct tcaaatcacg tcagctctat
    15061 ctgcaatctc aaaacactgt tttgagcaac ctgtggctag ctacctagtt tgatctttga
    15121 ttttcattga gtattagtct ctagtgtttg tttagcgtct taaagagaca tttgagaaga
    15181 ttagaaacag ttctctcttt tctcctagta taatgattgg taggaaggga gagagaagat
    15241 gaaatcaatg agaatcttat ttttgttagc tttaattcaa atcagtttga gtagctgttt
    15301 cctatggaag gaatgcatct tgtcctttaa acaaagtaca gcttttttca tcggaagcat
    15361 ggttttcgtt tcaggaatct gtgctggagt aaattatctt tatacccgta agcaagaagt
    15421 ccatagtgtc ctagccagta agaagtcggt gaagcttttt tacagtatgt tactcttaat
    15481 taatttgtta ggagctgttc ttgttttgtc agataacttg ttcatcaaaa atacgctgca
    15541 gcaagaatta gttgactttt tattgccatc cttctttttc ctatttgggc tagatttgct
    15601 gattttttta cccttgaaaa aatacgtgcg cgattttctt gctatgctgg acagaaaaaa
    15661 gacagtgttg gtgactattt tagcaacact tcttttctta agaaatccaa tgaccattgt
    15721 ctcacttctg atttatattg gactgggctt gttttttgca gcctatcttg tcccaaattc
    15781 ggttaagaag gaagtttcct tttatggtca tattttccga gatcttgtat tggtcattgt
    15841 tacgctcatt ttcttttaga gaaagcctgt tttttatgga tgttatgatg ataagtttag
    15901 taggaaaata gacacaaaag aaaagttttt ggtataataa gagtatgtac acaaaaaatg
    15961 aagaagagtt gcaagcctta ggggagcgtt tgggccatct attagcaaag aatgatgttt
    16021 taatcttaac tggagaactg ggtgcaggta aaacgacctt tactaaagga cttgcaaaag
    16081 gattacagat ttctcaaatg attaaaagtc ccacctatac tatcgtgaga gagtatgaag
    16141 gtcgacttcc actttatcac ctagatgttt atcgtattga aggagatgct gattctatcg
    16201 acttggatga gtttatcttt ggtggcggcg tgactgttat tgagtgggga aatctcttag
    16261 gagatgcctt gccagatgct tatttagaat tggaaattct aaaagaagca gatggacgcc
    16321 gtttaaattt tcaggcaaag ggtttgcgtg ctgagaaatt gttagaggag cttcaatatg
    16381 gagtatgaat tgctcattag ggaagcagag cccaaagatg cagctgaatt agtggccttt
    16441 ttaaatcgtg tgagtttgga gacagacttt accagcctag acggagatgg tattctcttg
    16501 actagtgagg agatggaaat attcctcaac aagcaagcta gttcggacaa tcagataacc
    16561 ttacttgcat tcttaaatgg caaaattgct ggtattgtaa atattacagc tgatcagcgt
    16621 aagagagtcc gtcatattgg agatctcttc attgtgattg gaaaaagata ttggaataat
    16681 ggcttgggaa gtttgttgct agaagaagcg atagagtggg cacaagcaag tggcattctg
    16741 cgtcgtctcc aactgactgt ccaaactcgt aatcaagcag cagtccatct ttatcaaaag
    16801 catggctttg tcattgaagg tagccaagag cgtggggcat atatagaaga agggaaattt
    16861 atcgatgttt acttgatggg taaactgata ggttagtaga aatatggtta aaaaaattat
    16921 tggaatggtg ctagctttac tttctgtaac tgtagtagga gtaggtgttt ttgcttatac
    16981 tatttatcaa caagggacag aaaccttagc taaaacctat aaaaaaatcg gtgaagaaac
    17041 caaggttatt gaagcgactg aacctctaac cattctgtta atgggagtgg acaccggaaa
    17101 tgttgaacga actgaaactt gggtcggtag aagtgatagc atgatcttga tgacagtgaa
    17161 tcctaaaacg aaaaaaacaa caatgatgag tttagagcgg gatattctga cgcgcattga
    17221 atcagggaat ggtcaggctc atgaagcgaa actgaactca gcatatgcag atggtggagc
    17281 agagcttgct atagaaacca ttcaaaaaat gatgaatatc catattgatc gctatgtgat
    17341 ggtcaatatg agagggttgc aaaaactagt ggatgcagta ggaggtatta cagtcaataa
    17401 tatcctaggt ttcccaattt ctatcagtga ccaagaagaa tttaatacta tttctatcgg
    17461 tgttggggag caacatattg ggggagaaga agccctagtc tatgcacgaa tgcgttacca
    17521 agatcctgag ggggattatg gtcgtcaaaa acgtcaacgt gaagttattc aaaaagtcat
    17581 ggaaaaagct ctcagtttaa atagcgttgg tcattatcaa gagattctaa aagctttgag
    17641 tgacaatatg cagaccaata ttgatttgtc tgcaaaaagt atccctaact tgctaggcta
    17701 taaagattca tttaaaacca ttgaaactca gcagttgcag ggtgaaggag agatacttca
    17761 aggtgtttct taccagattg tttcgagagc acatatgttg gaaatgcaaa atatactccg
    17821 acgttctttg ggacaagaag aagttactca gcttgaaacc aatgcggttt tatttgaaga
    17881 tttatttggc agagcacctg ttggtgatga agataattaa cttttgatac aaataaaaaa
    17941 atcaatcgta ggaaaattcc tgcgattttt tcaaaaaaat acgaatagat aggtaggagg
    18001 aaacatgaaa gcagaaatca ttgctgttgg aacagagatt ttgacaggac agattgtcaa
    18061 caccaatgcc cagtttttgt cggaaaaact agctgagatt ggggtagatg tatattttca
    18121 gacggctgta ggagacaatg aagttcgtct cttgtctttg cttgagattg ccagtcaacg
    18181 tagcagtctg gtgattttga caggcggttt ggggccaact gaggacgacc taaccaaaca
    18241 aaccctagct aaatttttag ggaaagcatt agtctttgat cctcaggctc aggagaagtt
    18301 ggatatcttt tttgccctgc gaccagacta tgcccgaaca ccgaataacg aaagacaagc
    18361 tcaaattgta gaaggagcga ttccactgcc aaacgaaaca ggactggctg ttggaggaaa
    18421 attagaagta gacggagtga cctatgtcgt ccttccaggt ccgccaagtg aattgaaacc
    18481 catggtctta aaccaacttc tacccaagtt gatgacaggg agcaagctgt attcccgagt
    18541 tcttcgtttc tttgggattg gcgagagcca gttggttacg attttggctg atttaattga
    18601 taatcagatc gatcctacct tggcccctta tgccaagaca ggagaagtca ctctacgtct
    18661 gtcaacaaag gctagcagtc aagaagaggc gaatcaagcg ctggatatct tggaaaatca
    18721 aatcttggac tgccagactt tcgaaggaat ttctttacga gacttttgct atggttatgg
    18781 ggaagaaact agtttagcca gcattgtggt agaagaactg aaaaggcaag ggaaaaccat
    18841 cgcggctgca gagagtttaa cggcaggtct tttccaagct accgtggcga atttttctgg
    18901 agcttcaagt atatttaagg gtggttttgt gacctatagc ttggaggaaa aatcaaggat
    18961 gttggatatt cctgccaaga atttggaaga acatggtgtg gtgtctgaat ttacagctca
    19021 gaagatggct gagcaggcac gaagcaagac ccagtctgat tttggaatta gtttgaccgg
    19081 agtggcagga ccagatagcc tagaaggaca cccagttggg acagtcttca taggcttggc
    19141 gcaagagcaa ggaactgagg ttatcaaggt taatattgga ggcagaagcc gagcagatgt
    19201 acgtcatatt gcggttatgc atgcctttaa cctagttcgc aaggctttat taagtgacta
    19261 acttttgata taatagtaga taggtctgag gatcattaga atgtaggaga atagaatggc
    19321 gaaaaaacca aaaaaattag aagaaatttc aaaaaaattt ggggcagaac gtgaaaaggc
    19381 cttgaatgat gctcttaaat tgattgagaa agactttggt aaaggatcaa tcatgcgttt
    19441 gggtgaacgt gcggagcaaa aggtgcaagt gatgagctca ggttctttag ctcttgacat
    19501 tgcccttggc tcaggtggtt atcctaaggg acgtatcatc gaaatctatg gcccagagtc
    19561 atctggtaag acaacggttg cccttcatgc agttgcacaa gcgcaaaaag aaggtgggat
    19621 tgctgccttt atcgatgcgg aacatgccct tgatccagct tatgctgcgg cccttggtgt
    19681 caatattgac gaattgctct tgtctcaacc agactcagga gagcaaggtc ttgagattgc
    19741 gggaaaattg attgactcag gtgcagttga tcttgtcgta gtcgactcag ttgctgccct
    19801 tgttcctcgt gcggaaattg atggagatat cggagatagc catgttggtt tgcaggctcg
    19861 tatgatgagc caggccatgc gtaaacttgg cgcctctatc aataaaacca aaacaattgc
    19921 catttttatc aaccaattgc gtgaaaaagt tggagtgatg tttggaaatc cagaaacaac
    19981 accgggcgga cgtgctttga aattctatgc ttcagtccgc ttggatgttc gtggtaatac
    20041 acaaattaag ggaactggtg atcaaaaaga aaccaatgtc ggtaaagaaa ctaagattaa
    20101 ggttgtaaaa aataaggtag ctccaccgtt taaggaagcc gtagttgaaa ttatgtacgg
    20161 agaaggaatt tctaagactg gtgagctttt gaagattgca agcgatttgg atattatcaa
    20221 aaaagcaggg gcttggtatt cttacaaaga tgaaaaaatt gggcaaggtt ctgagaatgc
    20281 taagaaatac ttggcagagc acccagaaat ctttgatgaa attgataagc aagtccgttc
    20341 taaatttggc ttgattgatg gagaagaagt ttcagaacaa gatactgaaa acaaaaaaga
    20401 tgagccaaag aaagaagaag cagtgaatga agaagttccg cttgacttag gcgatgaact
    20461 tgaaatcgaa attgaagaat aagctgttaa agcagtggag aaatccgcta ctttttcgat
    20521 ttttgattca agtttttaga ttatatatag tagcttgaaa taagatatga acaactttat
    20581 taggaaagtc aaattaattt ctagaaatgt tttagcagct acagcgtact attccaaact
    20641 caaccaacta taatagatcg aaactagaat agtacacatc tacttctaaa acattgttaa
    20701 aaatcgattt gactgtcctt atttcattcc gctatatata agtttgctgt ttcttgtcgc
    20761 tcctctggaa agctgatata atagctttat gaataaaaaa cgaacagtgg acctgataca
    20821 tggtccgatt cttccctcgc tcttaagctt cacctttcca atcttgctat caaatatttt
    20881 tcaacagctc tataacactg ctgatgtctt gattgttgga cgatttcttg gtcaagaatc
    20941 cttggctgca gtaggagcga cgacagcgat ttttgacctg attgtaggct ttacacttgg
    21001 tgttggcaat ggcatgggga ttgtcattgc tcgttattat ggggctcgga atttcactaa
    21061 aatcaaggaa gcagtagcag ccacctggat tttaggtgct cttttgagca ttctagttat
    21121 gttgctgggc tttcttggct tgtatcctct cttgcaatac ttagatactc ctgcagaaat
    21181 tcttcctcaa tcttatcaat atatttctat gattgtgacc tgtgtaggtg tcagctttgc
    21241 ttataatctt tttgcaggct tgttgcggtc tattggtgac agtctagcag ccctgggatt
    21301 tctgattttc tctgccttgg ttaatgtggt tctggatctc tattttatta cgcaattgca
    21361 tctgggagtt caatccgcag gacttgctac cattatttcg caaggtttat cagcggttct
    21421 ctgcttttat tatattcgta aaagtgtgcc agaactcttg ccacagttta aacatttcaa
    21481 atgggacaaa agcttgtacg cggatctctt ggagcaaggt ttggctatgg gcttgatgag
    21541 ttcaattgta tctatcggca gtgtgatttt acagttttct gttaatacat ttggtgcagt
    21601 gattattagt gcccagacgg cagctcgacg cattatgacc tttgcccttc ttcctatgac
    21661 cgctatttct gcatcaatga cgacctttgc ttctcagaat ctaggagcta agcgacctga
    21721 ccgcattgtt caaggtcttc gaatcggcag tcgtttaagt atatcctggg cagtttttgt
    21781 ttgtattttc ctcttttttg ccagtccagc cttggtttcc ttcttggcta gttcgacaga
    21841 tggttacttg atagaaaatg gaagtctcta tctgcaaatc agttcagcct tttatcccat
    21901 tttgagcctc ttgttgattt atcgcaattg cttgcagggc ttggggcaga agatccttcc
    21961 tctagtttct agctttattg aactaatcgg aaaaatcgtt tttgtggttt tgattattcc
    22021 ttgggcagga tataagggtg ttatcctttg tgaacctctt atctgggttg ccatgacagt
    22081 tcaactgtac ttctcactat tccgtcatcc cttgataaaa gaaggaaagg caattttggc
    22141 aaccaaagtg caatcctagt tggatttact gaataaaatc catttcctct agtgaacatc
    22201 gaaaaaactt gtgttctctt ctttagtttg gtgttgaaaa tagtttaaca gacttttgac
    22261 ttcttttata tgatataata aagtatagta tttatgaaaa ggacatatag agactgtaaa
    22321 aatatacttt tgaaaagctt tttagtctgg ggtgttattg tagatagaat gcagaccttg
    22381 tcagtcctat ttacagtgtc aaaatagtgc gttttgaggt tctatctaca agcctaatcg
    22441 tgactaagat tgtcttcttt gtaaggtaga aataaaggag tttctggttc tggattgtaa
    22501 aaaatgagtt gttttaattg ataaggagta gaatatggaa attaatgtga gtaaattaag
    22561 aacagatttg cctcaagtcg gcgtgcaacc atataggcaa gtacacgcac actcaactgg
    22621 gaatccgcat tcaaccgtac agaatgaagc ggattatcac tggcggaaag acccagaatt
    22681 aggttttttc tcgcacattg ttgggaacgg ttgcatcatg caggtaggac ctgttgataa
    22741 tggtgcctgg gacgttgggg gcggttggaa tgctgaaacc tatgcagcgg ttgaactgat
    22801 tgaaagccat tcaactaaag aagagttcat gacggactac cgcctttata tcgaactctt
    22861 acgcaatcta gcagatgaag caggtttgcc gaaaacgctt gatacaggga gtttagctgg
    22921 aattaaaacg cacgagtatt gcacgaataa ccaaccaaac aaccactcag accatgtgga
    22981 tccataccct t
//
