GCF_900036145.1 - 8 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

NZ_FEOS01000001.1 (Streptococcus pneumoniae)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1.1	RiPP-like	16,006	29,104
Region 1.2	RiPP-like	79,419	97,753

NZ_FEOS01000002.1 (Streptococcus pneumoniae)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 2.1	lanthipeptide-class-iv	174,527	197,136

NZ_FEOS01000003.1 (Streptococcus pneumoniae)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 3.1	lanthipeptide-class-ii	44,305	67,295

NZ_FEOS01000008.1 (Streptococcus pneumoniae)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 8.1	terpene-precursor	81,783	99,992

NZ_FEOS01000010.1 (Streptococcus pneumoniae)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 10.1	T3PKS	25,403	66,575

NZ_FEOS01000014.1 (Streptococcus pneumoniae)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 14.1	RiPP-like	43,513	48,824

NZ_FEOS01000026.1 (Streptococcus pneumoniae)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 26.1	RiPP-like	14,697	20,969

Region	Type	From	To	Most similar known cluster
Region 1.1	RiPP-like	16,006	29,104
Region 1.2	RiPP-like	79,419	97,753
Region 2.1	lanthipeptide-class-iv	174,527	197,136
Region 3.1	lanthipeptide-class-ii	44,305	67,295
Region 8.1	terpene-precursor	81,783	99,992
Region 10.1	T3PKS	25,403	66,575
Region 14.1	RiPP-like	43,513	48,824
Region 26.1	RiPP-like	14,697	20,969

No secondary metabolite regions were found in these records:: NZ_FEOS01000004.1 (Streptococcus pneumoniae); NZ_FEOS01000005.1 (Streptococcus pneumoniae); NZ_FEOS01000006.1 (Streptococcus pneumoniae); NZ_FEOS01000007.1 (Streptococcus pneumoniae); NZ_FEOS01000009.1 (Streptococcus pneumoniae); NZ_FEOS01000011.1 (Streptococcus pneumoniae); NZ_FEOS01000012.1 (Streptococcus pneumoniae); NZ_FEOS01000013.1 (Streptococcus pneumoniae); NZ_FEOS01000015.1 (Streptococcus pneumoniae); NZ_FEOS01000016.1 (Streptococcus pneumoniae); NZ_FEOS01000017.1 (Streptococcus pneumoniae); NZ_FEOS01000018.1 (Streptococcus pneumoniae); NZ_FEOS01000019.1 (Streptococcus pneumoniae); NZ_FEOS01000020.1 (Streptococcus pneumoniae); NZ_FEOS01000021.1 (Streptococcus pneumoniae); NZ_FEOS01000022.1 (Streptococcus pneumoniae); NZ_FEOS01000023.1 (Streptococcus pneumoniae); NZ_FEOS01000024.1 (Streptococcus pneumoniae); NZ_FEOS01000025.1 (Streptococcus pneumoniae); NZ_FEOS01000027.1 (Streptococcus pneumoniae); NZ_FEOS01000028.1 (Streptococcus pneumoniae); NZ_FEOS01000029.1 (Streptococcus pneumoniae); NZ_FEOS01000030.1 (Streptococcus pneumoniae); NZ_FEOS01000031.1 (Streptococcus pneumoniae); NZ_FEOS01000032.1 (Streptococcus pneumoniae); NZ_FEOS01000033.1 (Streptococcus pneumoniae); NZ_FEOS01000034.1 (Streptococcus pneumoniae); NZ_FEOS01000035.1 (Streptococcus pneumoniae); NZ_FEOS01000036.1 (Streptococcus pneumoniae); NZ_FEOS01000037.1 (Streptococcus pneumoniae)

Compact view

NZ_FEOS01000001.1 - Region 1 - RiPP-like

Download region GenBank file

Download region SVG

Location: 16,006 - 29,104 nt. (total: 13,099 nt) Show pHMM detection rules used

RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: aminotransferase

A1178_RS00130: aminotransferase

smcogs: SMCOG1019: aminotransferase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002579.2	0.54	ribosomal	carnobacteriocin XY	Carnobacterium maltaromaticum
BGC0002577.2	0.51	ribosomal	lactococcin G	Lactococcus lactis
BGC0000617.5	0.50	ribosomal	coagulin	Bacillus coagulans
BGC0000624.3	0.49	ribosomal	salivaricin CRL1328 α peptide, salivaricin CRL1328 β peptide	Lactobacillus salivarius
BGC0000619.3	0.47	ribosomal	gassericin T	Lactobacillus gasseri
BGC0001602.3	0.47	ribosomal	gassericin-T	Lactobacillus gasseri
BGC0001388.3	0.47	ribosomal	gassericin E	Lactobacillus gasseri
BGC0001229.4	0.43	ribosomal	SBI-06990 A1, SBI-06989 A2	Streptomyces bingchenggensis BCW-1
BGC0000558.5	0.42	ribosomal	sublancin 168	Bacillus subtilis subsp. subtilis str. 168
BGC0002005.2	0.40	ribosomal	RaxX	Xanthomonas oryzae pv. oryzae

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002579.2	0.54	ribosomal	carnobacteriocin XY	Carnobacterium maltaromaticum
BGC0002577.2	0.51	ribosomal	lactococcin G	Lactococcus lactis
BGC0000617.5	0.50	ribosomal	coagulin	Bacillus coagulans
BGC0000624.3	0.49	ribosomal	salivaricin CRL1328 α peptide, salivaricin CRL1328 β peptide	Lactobacillus salivarius
BGC0000619.3	0.47	ribosomal	gassericin T	Lactobacillus gasseri
BGC0001602.3	0.47	ribosomal	gassericin-T	Lactobacillus gasseri
BGC0001388.3	0.47	ribosomal	gassericin E	Lactobacillus gasseri
BGC0001229.4	0.43	ribosomal	SBI-06990 A1, SBI-06989 A2	Streptomyces bingchenggensis BCW-1
BGC0000558.5	0.42	ribosomal	sublancin 168	Bacillus subtilis subsp. subtilis str. 168
BGC0002005.2	0.40	ribosomal	RaxX	Xanthomonas oryzae pv. oryzae

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.31 out of 26.06

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.09 out of 26.06

Confidence: medium

Additional weak hits (5):

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.17 out of 26.85

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.29 out of 26.06

Confidence: weak

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 21.48 out of 29.25

Confidence: weak

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 21.98 out of 29.25

Confidence: weak

HypR

Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 18.94 out of 22.40

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
MogR	Repressor of flagellar motility genes

NZ_FEOS01000001.1 - Region 2 - RiPP-like

Download region GenBank file

Download region SVG

Location: 79,419 - 97,753 nt. (total: 18,335 nt) Show pHMM detection rules used

RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Hydrolases: hydrolase

A1178_RS00425: HAD-superfamily hydrolase, subfamily IA, variant

smcogs: SMCOG1115: HAD-superfamily hydrolase, subfamily IA, variant

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000558.5	0.48	ribosomal	sublancin 168	Bacillus subtilis subsp. subtilis str. 168
BGC0000623.3	0.48	ribosomal	plantaricin W α, plantaricin W β	Lactobacillus plantarum
BGC0002579.2	0.47	ribosomal	carnobacteriocin XY	Carnobacterium maltaromaticum
BGC0002674.2	0.46	ribosomal	enterocin F4-9	Enterococcus faecalis
BGC0001862.4	0.44	ribosomal	pallidocin	Aeribacillus pallidus
BGC0002698.2	0.44	ribosomal	phaeornamide	Pseudophaeobacter arcticus DSM 23566
BGC0000554.4	0.44	ribosomal	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0000504.5	0.44	ribosomal	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0001229.4	0.43	ribosomal	SBI-06990 A1, SBI-06989 A2	Streptomyces bingchenggensis BCW-1
BGC0002577.2	0.43	ribosomal	lactococcin G	Lactococcus lactis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000558.5	0.48	ribosomal	sublancin 168	Bacillus subtilis subsp. subtilis str. 168
BGC0000623.3	0.48	ribosomal	plantaricin W α, plantaricin W β	Lactobacillus plantarum
BGC0002579.2	0.47	ribosomal	carnobacteriocin XY	Carnobacterium maltaromaticum
BGC0002674.2	0.46	ribosomal	enterocin F4-9	Enterococcus faecalis
BGC0001862.4	0.44	ribosomal	pallidocin	Aeribacillus pallidus
BGC0002698.2	0.44	ribosomal	phaeornamide	Pseudophaeobacter arcticus DSM 23566
BGC0000554.4	0.44	ribosomal	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0000504.5	0.44	ribosomal	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0001229.4	0.43	ribosomal	SBI-06990 A1, SBI-06989 A2	Streptomyces bingchenggensis BCW-1
BGC0002577.2	0.43	ribosomal	lactococcin G	Lactococcus lactis

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 25.42 out of 26.06

Confidence: strong

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 21.57 out of 26.33

Confidence: medium

LexA variant 3

Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 25.52 out of 32.93

Confidence: medium

Additional weak hits (3):

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 26.23 out of 31.73

Confidence: weak

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 22.38 out of 29.25

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 24.79 out of 33.14

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
ANR	Anaerobic transcriptional regulator
LexA variant 3	Repressor of DNA damage response
MogR	Repressor of flagellar motility genes

NZ_FEOS01000002.1 - Region 1 - lanthipeptide-class-iv

Download region GenBank file

Download region SVG

Location: 174,527 - 197,136 nt. (total: 22,610 nt) Show pHMM detection rules used

lanthipeptide-class-iv: (cds(LANC_like and Pkinase) and not micKC)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lanthipeptides

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

No tailoring functions detected.

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000513.3	0.55	ribosomal	Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3	Saccharopolyspora erythraea NRRL 2338
BGC0000551.5	0.54	ribosomal	SapB	Streptomyces coelicolor A3(2)
BGC0001226.4	0.52	ribosomal	streptocollin	Streptomyces collinus Tu 365
BGC0000563.4	0.51	ribosomal	venezuelin	Streptomyces venezuelae ATCC 10712
BGC0000519.4	0.49	ribosomal	labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3	Actinomadura namibiensis
BGC0000501.3	0.49	ribosomal	catenulipeptin	Catenulispora acidiphila DSM 44928
BGC0000496.5	0.46	ribosomal	AmfS	Streptomyces griseus subsp. griseus NBRC 13350
BGC0002698.2	0.45	ribosomal	phaeornamide	Pseudophaeobacter arcticus DSM 23566
BGC0000518.3	0.44	ribosomal	informatipeptin	Streptomyces viridochromogenes DSM 40736
BGC0000504.5	0.43	ribosomal	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000513.3	0.55	ribosomal	Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3	Saccharopolyspora erythraea NRRL 2338
BGC0000551.5	0.54	ribosomal	SapB	Streptomyces coelicolor A3(2)
BGC0001226.4	0.52	ribosomal	streptocollin	Streptomyces collinus Tu 365
BGC0000563.4	0.51	ribosomal	venezuelin	Streptomyces venezuelae ATCC 10712
BGC0000519.4	0.49	ribosomal	labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3	Actinomadura namibiensis
BGC0000501.3	0.49	ribosomal	catenulipeptin	Catenulispora acidiphila DSM 44928
BGC0000496.5	0.46	ribosomal	AmfS	Streptomyces griseus subsp. griseus NBRC 13350
BGC0002698.2	0.45	ribosomal	phaeornamide	Pseudophaeobacter arcticus DSM 23566
BGC0000518.3	0.44	ribosomal	informatipeptin	Streptomyces viridochromogenes DSM 40736
BGC0000504.5	0.43	ribosomal	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Lanthipeptide predictions

Lanthipeptides - No core peptides found.

Transcription Factor Binding Sites

No hits above weak threshold.

Weak hits (4):

HipB

Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 23.05 out of 33.73

Confidence: weak

AfsQ1

Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 16.79 out of 19.52

Confidence: weak

NuR

Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 22.88 out of 30.98

Confidence: weak

AfsQ1

Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 16.35 out of 19.52

Confidence: weak

Lanthipeptides

TFBS Finder

Core peptide predictions

No core peptides found.

TFBS definitions

Regulator	Description

NZ_FEOS01000003.1 - Region 1 - lanthipeptide-class-ii

Download region GenBank file

Download region SVG

Location: 44,305 - 67,295 nt. (total: 22,991 nt) Show pHMM detection rules used

lanthipeptide-class-ii: cds(LANC_like and DUF4135)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lanthipeptides

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Hydrolases: protease

A1178_RS03060: alkaline serine protease, subtilase family

smcogs: SMCOG1075: alkaline serine protease, subtilase family

Lyases: cyclase

A1178_RS03080: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000500.5	0.60	ribosomal	carnolysin A1, carnolysin A2	Carnobacterium maltaromaticum
BGC0000504.5	0.51	ribosomal	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0001555.4	0.51	ribosomal	colicin V	Escherichia coli chi7122
BGC0000554.4	0.50	ribosomal	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0000590.5	0.50	ribosomal	microcin N	Escherichia coli
BGC0002698.2	0.50	ribosomal	phaeornamide	Pseudophaeobacter arcticus DSM 23566
BGC0000622.5	0.49	ribosomal	megacin	Bacillus megaterium
BGC0000623.3	0.49	ribosomal	plantaricin W α, plantaricin W β	Lactobacillus plantarum
BGC0000502.5	0.49	ribosomal	cerecidin, cerecidin A1, cerecidin A2, cerecidin A3, cerecidin A4, cerecidin A5, cerecidin A6, cerecidin A7	Bacillus cereus
BGC0001407.5	0.49	ribosomal	bicereucin	Bacillus cereus SJ1

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000500.5	0.60	ribosomal	carnolysin A1, carnolysin A2	Carnobacterium maltaromaticum
BGC0000504.5	0.51	ribosomal	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0001555.4	0.51	ribosomal	colicin V	Escherichia coli chi7122
BGC0000554.4	0.50	ribosomal	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0000590.5	0.50	ribosomal	microcin N	Escherichia coli
BGC0002698.2	0.50	ribosomal	phaeornamide	Pseudophaeobacter arcticus DSM 23566
BGC0000622.5	0.49	ribosomal	megacin	Bacillus megaterium
BGC0000623.3	0.49	ribosomal	plantaricin W α, plantaricin W β	Lactobacillus plantarum
BGC0000502.5	0.49	ribosomal	cerecidin, cerecidin A1, cerecidin A2, cerecidin A3, cerecidin A4, cerecidin A5, cerecidin A6, cerecidin A7	Bacillus cereus
BGC0001407.5	0.49	ribosomal	bicereucin	Bacillus cereus SJ1

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Lanthipeptide predictions

Lanthipeptide(s) for A1178_RS03080

A1178_RS03085

Leader:

MKNDFVIGKSLKELSLEEMQLVYGG

Core:

TDGADPRSTIICSATLSFIASYLGSAQTRCGKDNKKK

Core with dehydrations:

DhbDGADPRDhaDhbIICysDhaADhbLDhaFIADhaYLGDhaAQDhbRCysGKDNKKK

antiSMASH-DB 4.0 matches for A1178_RS03085

100.0%

NC_003028.3and 45 others:

NC_003098.1 Lanthipeptides: SPR_RS08865_lanthipeptideNC_011900.1 Lanthipeptides: SPN23F_RS10050_lanthipeptideNC_012466.1 Lanthipeptides: SPJ_RS09635_lanthipeptideNZ_CFDV01000030.1 Lanthipeptides: AQB43_RS08320_lanthipeptideNZ_CFVJ01000005.1 Lanthipeptides: AP598_RS03265_lanthipeptideNZ_CGGJ01000006.1 Lanthipeptides: AP607_RS03205_lanthipeptideNZ_CHVQ01000007.1 Lanthipeptides: AQF85_RS04285_lanthipeptideNZ_CJZM01000008.1 Lanthipeptides: AEE29_RS04155_lanthipeptideNZ_CLHL01000007.1 Lanthipeptides: AE723_RS05750_lanthipeptideNZ_CMIW01000004.1 Lanthipeptides: AD046_RS04075_lanthipeptideNZ_CMKL01000017.1 Lanthipeptides: AD734_RS09110_lanthipeptideNZ_CP035244.1 Lanthipeptides: EQH36_RS09105_lanthipeptideNZ_CP035253.1 Lanthipeptides: EQH27_RS09740_lanthipeptideNZ_CP082820.1 Lanthipeptides: K8B76_RS08865_lanthipeptideNZ_CPPE01000023.1 Lanthipeptides: AD654_RS06875_lanthipeptideNZ_CPRX01000013.1 Lanthipeptides: AEE77_RS05820_lanthipeptideNZ_CPTT01000011.1 Lanthipeptides: AEH42_RS06000_lanthipeptideNZ_CRAW01000006.1 Lanthipeptides: AK725_RS04395_lanthipeptideNZ_CRXO01000010.1 Lanthipeptides: AKU38_RS05260_lanthipeptideNZ_FCRW01000008.1 Lanthipeptides: A1N73_RS07425_lanthipeptideNZ_FDDE01000015.1 Lanthipeptides: A1A23_RS09705_lanthipeptideNZ_FDFR01000008.1 Lanthipeptides: A1O50_RS09320_lanthipeptideNZ_FDGF01000009.1 Lanthipeptides: A0899_RS06595_lanthipeptideNZ_FDQP01000009.1 Lanthipeptides: A1S42_RS08050_lanthipeptideNZ_FECM01000008.1 Lanthipeptides: A1930_RS06475_lanthipeptideNZ_FEEQ01000001.1 Lanthipeptides: A1T31_RS01145_lanthipeptideNZ_FEOS01000003.1 Lanthipeptides: A1178_RS03085_lanthipeptideNZ_FFTU01000009.1 Lanthipeptides: A1K37_RS06335_lanthipeptideNZ_FHJP02000011.1 Lanthipeptides: A1O79_RS07375_lanthipeptideNZ_FHRS02000028.1 Lanthipeptides: A1898_RS09820_lanthipeptideNZ_FIXQ01000010.1 Lanthipeptides: AZ721_RS04790_lanthipeptideNZ_FZDX01000018.1 Lanthipeptides: CFW91_RS09480_lanthipeptideNZ_FZEI01000008.1 Lanthipeptides: CFW58_RS06410_lanthipeptideNZ_JACVHZ010000010.1 Lanthipeptides: ICJ99_RS03880_lanthipeptideNZ_JAGFAE010000038.1 Lanthipeptides: J5E60_RS09005_lanthipeptideNZ_JALDUX010000010.1 Lanthipeptides: M1F92_RS09535_lanthipeptideNZ_JAMYJM010000002.1 Lanthipeptides: NKE69_RS04885_lanthipeptideNZ_LR216014.1 Lanthipeptides: E0F05_RS09385_lanthipeptideNZ_LR216016.1 Lanthipeptides: E0F10_RS10160_lanthipeptideNZ_LR216019.1 Lanthipeptides: E0E94_RS09635_lanthipeptideNZ_LR216027.1 Lanthipeptides: E0E81_RS09205_lanthipeptideNZ_LR216049.1 Lanthipeptides: E0E96_RS09540_lanthipeptideNZ_LR216064.1 Lanthipeptides: E0F31_RS09525_lanthipeptideNZ_LR536843.1 Lanthipeptides: E0F34_RS09600_lanthipeptideNZ_NANQ01000003.1 Lanthipeptides: B5K28_RS01935_lanthipeptide

Lanthipeptides: SP_RS09795_lanthipeptide

1

TDGADPRSTIICSATLSFIASYLGSAQTRCGKDNKKK

37

TDGADPRSTIICSATLSFIASYLGSAQTRCGKDNKKK

1

TDGADPRSTIICSATLSFIASYLGSAQTRCGKDNKKK

37

97.3%

NZ_MRXY01000010.1:

Lanthipeptides: BTU63_RS06305_lanthipeptide

1

TDGADPRSTIICSATLSFIASYLGSAQTRCGKDNKKK

37

TDGADPRS+IICSATLSFIASYLGSAQTRCGKDNKKK

1

TDGADPRSSIICSATLSFIASYLGSAQTRCGKDNKKK

37

97.3%

NZ_NAOJ01000022.1:

Lanthipeptides: B5K31_RS08015_lanthipeptide

1

TDGADPRSTIICSATLSFIASYLGSAQTRCGKDNKKK

37

TDGADPRST ICSATLSFIASYLGSAQTRCGKDNKKK

1

TDGADPRSTTICSATLSFIASYLGSAQTRCGKDNKKK

37

with 20 more sequence matches

Only the first 10 are displayed here.

70.3%

NZ_CP026035.1:

Lanthipeptides: C2H96_RS00310_lanthipeptide

4

ADPRSTIICSATLSFIASYLGSAQTRCGKDNKK

36

AD RST ICSA +SFIA+YLGSA T CGKDNKK

5

ADVRSTPICSAGISFIATYLGSAATNCGKDNKK

37

59.5%

NZ_CP094446.1:

Lanthipeptides: L3476_RS23820_lanthipeptide

2

DGADP--RSTIICSATLSFIASYLGSAQTRCGKDNKK

36

DG D RST+IC SFI SYL SA +CGK NKK

1

DGMDVEVRSTLICGVGASFIGSYLASAAFKCGKKNKK

37

56.8%

NZ_FNYB01000021.1:

Lanthipeptides: BMZ34_RS24360_lanthipeptide

3

GADPRSTIICSATLSFIASYLGSAQTRCGKDNKKK

37

G DPR+T SF+ASY+ SAQ RCGKDNK K

2

GVDPRTTP-SPLLASFVASYIASAQYRCGKDNKGK

35

56.8%

NZ_JACSNF010000005.1and 1 other:

NZ_LMPR01000013.1 Lanthipeptides: ASF99_RS16385_lanthipeptide

Lanthipeptides: KNQ12_RS14670_lanthipeptide

4

ADPRSTIICSATLSFIASYLGSAQTRCGKDNKK

36

D RS+++CSA LSF+ SYL SA +CGKDNKK

4

VDVRSSLVCSALLSFVGSYLASAGLKCGKDNKK

36

56.8%

NZ_KB976303.1:

Lanthipeptides: IGY_RS26050_lanthipeptide

3

GADPRSTIICSATLSFIASYLGSAQTRCGKDNKKK

37

G DPR+T SF+ASY+ SAQ RCGKDNK K

2

GVDPRTTP-SPLLASFVASYIASAQFRCGKDNKGK

35

55.3%

NZ_LWAG01000079.1:

Lanthipeptides: A4R27_RS25235_lanthipeptide

4

ADPRSTIICSATLSFIASYLGSAQTRCGKDNKKK

37

A+ RST+IC A +S I SYL SA +CGKDNK K

5

AEARSTLICGAGISLIGSYLASAAFKCGKDNKGK

38

54.1%

NZ_FNYB01000021.1:

Lanthipeptides: BMZ34_RS24355_lanthipeptide

3

GADPRSTIICSATLSFIASYLGSAQTRCGKDNKKK

37

G DPR+T SF+ASY+ SA+ RCGKDNK K

2

GVDPRTTP-SPLLASFVASYIASAEFRCGKDNKGK

35

51.4%

NZ_LN884299.1:

Lanthipeptides: BN2762_RS08665_lanthipeptide

4

ADPRSTIICSATLSFIASYLGSAQTRCGKDNK

35

A+ RST++C +SF+ASYL SA +CGKDNK

5

AEVRSTLLCGMGISFVASYLASAAFKCGKDNK

36

51.4%

NZ_NVMQ01000017.1:

Lanthipeptides: CON32_RS17790_lanthipeptide

3

GADPRSTIICSATLSFIASYLGSAQTRCGKDNKKK

37

G DPR+T SF+ASY+ SA+ +CGKDNK K

2

GVDPRTTP-SPLLASFVASYIASAEFKCGKDNKGK

35

48.6%

NZ_KN125582.1:

Lanthipeptides: DJ91_RS27545_lanthipeptide

3

GADPRSTIICSATLSFIASYLGSAQTRCGKDNK

35

G PR+T + SF+ASY+ SA+ RCGKDNK

2

GVTPRTTPATTLLASFVASYIASAEFRCGKDNK

34

A1178_RS03090

Leader:

MTNFNSNEKFCGKSLKSLSADEMSLIYGA

Core:

SDGAEPRWTPTPIILKSAAASSKVCISAAVSGIGGLVSYNNDCLG

Core with dehydrations:

DhaDGAEPRWDhbPDhbPIILKDhaAAADhaDhaKVCysIDhaAAVDhaGIGGLVDhaYNNDCysLG

antiSMASH-DB 4.0 matches for A1178_RS03090

100.0%

NC_003028.3and 39 others:

NC_003098.1 Lanthipeptides: SPR_RS08860_lanthipeptideNC_011900.1 Lanthipeptides: SPN23F_RS10045_lanthipeptideNC_012466.1 Lanthipeptides: SPJ_RS09630_lanthipeptideNZ_CFDV01000030.1 Lanthipeptides: AQB43_RS08315_lanthipeptideNZ_CFVJ01000005.1 Lanthipeptides: AP598_RS03270_lanthipeptideNZ_CGGJ01000006.1 Lanthipeptides: AP607_RS03210_lanthipeptideNZ_CHVQ01000007.1 Lanthipeptides: AQF85_RS04280_lanthipeptideNZ_CJZM01000008.1 Lanthipeptides: AEE29_RS04150_lanthipeptideNZ_CLHL01000007.1 Lanthipeptides: AE723_RS05755_lanthipeptideNZ_CMIW01000004.1 Lanthipeptides: AD046_RS04070_lanthipeptideNZ_CP035253.1 Lanthipeptides: EQH27_RS09735_lanthipeptideNZ_CP082820.1 Lanthipeptides: K8B76_RS08860_lanthipeptideNZ_CPRX01000013.1 Lanthipeptides: AEE77_RS05815_lanthipeptideNZ_CPTT01000011.1 Lanthipeptides: AEH42_RS06005_lanthipeptideNZ_CRAW01000006.1 Lanthipeptides: AK725_RS04390_lanthipeptideNZ_CRXO01000010.1 Lanthipeptides: AKU38_RS05255_lanthipeptideNZ_FCRW01000008.1 Lanthipeptides: A1N73_RS07430_lanthipeptideNZ_FDDE01000015.1 Lanthipeptides: A1A23_RS09710_lanthipeptideNZ_FDFR01000008.1 Lanthipeptides: A1O50_RS09315_lanthipeptideNZ_FDGF01000009.1 Lanthipeptides: A0899_RS06590_lanthipeptideNZ_FDQP01000009.1 Lanthipeptides: A1S42_RS08045_lanthipeptideNZ_FECM01000008.1 Lanthipeptides: A1930_RS06470_lanthipeptideNZ_FEEQ01000001.1 Lanthipeptides: A1T31_RS01150_lanthipeptideNZ_FEOS01000003.1 Lanthipeptides: A1178_RS03090_lanthipeptideNZ_FFTU01000009.1 Lanthipeptides: A1K37_RS06340_lanthipeptideNZ_FHRS02000028.1 Lanthipeptides: A1898_RS09825_lanthipeptideNZ_FIXQ01000010.1 Lanthipeptides: AZ721_RS04795_lanthipeptideNZ_FZDX01000018.1 Lanthipeptides: CFW91_RS09485_lanthipeptideNZ_FZEI01000008.1 Lanthipeptides: CFW58_RS06405_lanthipeptideNZ_JACVHZ010000010.1 Lanthipeptides: ICJ99_RS03885_lanthipeptideNZ_JAGFAE010000038.1 Lanthipeptides: J5E60_RS09010_lanthipeptideNZ_LR216014.1 Lanthipeptides: E0F05_RS09380_lanthipeptideNZ_LR216019.1 Lanthipeptides: E0E94_RS09630_lanthipeptideNZ_LR216027.1 Lanthipeptides: E0E81_RS09200_lanthipeptideNZ_LR216049.1 Lanthipeptides: E0E96_RS09535_lanthipeptideNZ_LR216064.1 Lanthipeptides: E0F31_RS09520_lanthipeptideNZ_LR536843.1 Lanthipeptides: E0F34_RS09595_lanthipeptideNZ_NANQ01000003.1 Lanthipeptides: B5K28_RS01930_lanthipeptideNZ_NAOJ01000022.1 Lanthipeptides: B5K31_RS08010_lanthipeptide

Lanthipeptides: SP_RS09790_lanthipeptide

1

SDGAEPRWTPTPIILKSAAASSKVCISAAVSGIGGLVSYNNDCLG

45

SDGAEPRWTPTPIILKSAAASSKVCISAAVSGIGGLVSYNNDCLG

1

SDGAEPRWTPTPIILKSAAASSKVCISAAVSGIGGLVSYNNDCLG

45

97.8%

NZ_CP035244.1and 3 others:

NZ_CPPE01000023.1 Lanthipeptides: AD654_RS06870_lanthipeptideNZ_FHJP02000011.1 Lanthipeptides: A1O79_RS07380_lanthipeptideNZ_LR216016.1 Lanthipeptides: E0F10_RS10155_lanthipeptide

Lanthipeptides: EQH36_RS09100_lanthipeptide

1

SDGAEPRWTPTPIILKSAAASSKVCISAAVSGIGGLVSYNNDCLG

45

SDGAEPRWTPTPIILKSAAASSK+CISAAVSGIGGLVSYNNDCLG

1

SDGAEPRWTPTPIILKSAAASSKICISAAVSGIGGLVSYNNDCLG

45

95.6%

NZ_JALDUX010000010.1:

Lanthipeptides: M1F92_RS09530_lanthipeptide

1

SDGAEPRWTPTPIILKSAAASSKVCISAAVSGIGGLVSYNNDCLG

45

SDGAEPRWTPTP+ILKSAAASSKVCISA VSGIGGLVSYNNDCLG

1

SDGAEPRWTPTPLILKSAAASSKVCISALVSGIGGLVSYNNDCLG

45

with 20 more sequence matches

Only the first 10 are displayed here.

91.1%

NZ_JAMYJM010000002.1:

Lanthipeptides: NKE69_RS04880_lanthipeptide

1

SDGAEPRWTPTPIILKSAAASSKVCISAAVSGIGGLVSYNNDCLG

45

SDGAEPRWTPTP ILKSA ASSKVCISA VSGIGG+VSYNNDCLG

1

SDGAEPRWTPTPFILKSATASSKVCISAVVSGIGGIVSYNNDCLG

45

84.4%

NZ_MRXY01000010.1:

Lanthipeptides: BTU63_RS06300_lanthipeptide

1

SDGAEPRWTPTPIILKSAAASSKVCISAAVSGIGGLVSYNNDCLG

45

SDGAEP WTPTP ILKSAA SSKVCISA +SGIGG+ SYNNDCLG

1

SDGAEPLWTPTPTILKSAARSSKVCISAIISGIGGIFSYNNDCLG

45

77.8%

NZ_CMKL01000017.1:

Lanthipeptides: AD734_RS09115_lanthipeptide

1

SDGAEPRWTPTPIILKSAAASSKVCISAAVSGIGG

35

SDGAEPRWTPTPIILKSAAASSKVCISAAVSGIGG

1

SDGAEPRWTPTPIILKSAAASSKVCISAAVSGIGG

35

54.3%

NZ_CP041405.1:

Lanthipeptides: FLT43_RS14400_lanthipeptide

5

EPRWTPT--PIILKSAAASSKVCISAAVSGIGGLVSYNNDCLG

45

EPR TPT P I + SSKVC+S S IGG+ S+NNDCLG

4

EPRATPTIVPAISAAVRTSSKVCLSLVASAIGGIASHNNDCLG

46

54.3%

NZ_LN884299.1:

Lanthipeptides: BN2762_RS08660_lanthipeptide

5

EPRWTPTPI--ILKSAAASSKVCISAAVSGIGGLVSYNNDCLG

45

+PR TPT + I++S A SSKVCISA S I G+VS N +CLG

4

DPRATPTIVASIIRSVAQSSKVCISAVGSAISGIVSNNKNCLG

46

53.3%

NZ_JACSPZ010000014.1:

Lanthipeptides: H9635_RS18390_lanthipeptide

5

EPRWTPTPIILKSAAASSKVCISAAVSGIGGLVSYNNDCLG

45

EP TP IL +A SSK C+ A+S I GLVSYN DCLG

5

EPHTTP---ILSAATKSSKKCL-GAISAISGLVSYNKDCLG

41

51.1%

NZ_LWAG01000079.1:

Lanthipeptides: A4R27_RS25230_lanthipeptide

5

EPRWTPTPIILKSAAASS-KVCISAAVSGIGGLVSYNNDCLG

45

+PRWTP ++AA S K+CISA S IGG+VSYN +C G

4

DPRWTPIASAAINSAARSSKICISAVGSAIGGIVSYNKNCAG

45

48.9%

NZ_CP094446.1:

Lanthipeptides: L3476_RS23825_lanthipeptide

5

EPRWTPTPIILKSAAASSKVCISAAVSGIGGLVSYNNDCLG

45

EPR TP I+ + SSK CISA S I G++S+N DCLG

4

EPRGTPATIV-SAVTRSSKPCISAIGSAISGIISHNKDCLG

43

48.9%

NZ_KB976303.1and 1 other:

NZ_KB976303.1 Lanthipeptides: IGY_RS26035_lanthipeptide

Lanthipeptides: IGY_RS26045_lanthipeptide

3

GAEPRWTPTPIILKSAAASSKVCISAAVSGIGGLVSYNNDCLG

45

G + R PT I++ + ASSK C+S VS I GL+SYN DC+G

2

GVDTRTHPTVIVV--SRASSKACMSG-VSAISGLLSYNKDCIG

41

46.7%

NZ_CP026035.1:

Lanthipeptides: C2H96_RS00305_lanthipeptide

4

AEPRWTP-TPIILKSAAASSKVCISAAVSGIGGLVSYNNDCLG

45

A+PRWTP +L + S+++CIS S I G+VS+N DCLG

3

ADPRWTPAVSAVLSAVGRSTRLCISGIGSAISGIVSHNKDCLG

45

MIBiG 4.0 matches for A1178_RS03090

8.9%

BGC0000582.4 (ADR72962.1):

Linaridin: cypemycin

11

TPIILKSAAASSKVCI

26

TP + + S +C+

5

TPTVAQFVIQGSTICL

20

allorf_046199_046306

Leader:

MTISLSRSVRCETKKTPAM

Core:

RVCVEGYTKKTPNAIQ

Core with dehydrations:

RVCysVEGYDhbKKDhbPNAIQ

antiSMASH-DB 4.0 matches for allorf_046199_046306

100.0%

NC_003028.3and 9 others:

NC_003098.1 Lanthipeptides: allorf_1743556_1743663_lanthipeptideNC_012466.1 Lanthipeptides: allorf_1823226_1823333_lanthipeptideNZ_CFVJ01000005.1 Lanthipeptides: allorf_65899_66006_lanthipeptideNZ_CP082820.1 Lanthipeptides: allorf_1783059_1783166_lanthipeptideNZ_FDGF01000009.1 Lanthipeptides: allorf_46146_46253_lanthipeptideNZ_FEOS01000003.1 Lanthipeptides: allorf_046199_046306_lanthipeptideNZ_FHRS02000028.1 Lanthipeptides: allorf_00109_00216_lanthipeptideNZ_JAGFAE010000038.1 Lanthipeptides: allorf_46811_46918_lanthipeptideNZ_LR216049.1 Lanthipeptides: allorf_1766843_1766950_lanthipeptide

Lanthipeptides: allorf_1861890_1861997_lanthipeptide

1

RVCVEGYTKKTPNAIQ

16

RVCVEGYTKKTPNAIQ

1

RVCVEGYTKKTPNAIQ

16

38.1%

NC_012470.1and 1 other:

NZ_CP078012.1 Lanthipeptides: allorf_1992325_1992417_lanthipeptide

Lanthipeptides: allorf_0874216_0874308_lanthipeptide

7

YTKKTPNAIQ

16

Y KKTPNA+Q

5

YYKKTPNALQ

14

33.3%

NZ_CP031443.1and 4 others:

NZ_FWZD01000067.1 Lassopeptides: BACERE00177_RS21400_lassopeptideNZ_NTYE01000016.1 Lassopeptides: CN490_RS29030_lassopeptideNZ_NUEY01000038.1 Lassopeptides: CN888_RS28205_lassopeptideNZ_QOSD01000019.1 Lassopeptides: DN410_RS14275_lassopeptide

Lassopeptides: MLA2C4_RS19250_lassopeptide

6

GYTKKTPNAIQ

16

G KTP+AIQ

1

GPGHKTPDAIQ

11

with 4 more sequence matches

28.6%

NZ_CAKJTI010000013.1and 1 other:

NZ_JACYOF010000019.1 Lassopeptides: IGI01_RS27610_lassopeptide

Lassopeptides: LRP84_RS13300_lassopeptide

6

GYTKKTPNAIQ

16

G KTP+A+Q

1

GPGHKTPDAVQ

11

28.6%

NZ_JALJRJ010000031.1:

Lassopeptides: OC439_RS28220_lassopeptide

3

CVEGYTKKTPNAI

15

C E Y + P AI

7

CRESYVTQKPRAI

19

28.6%

NZ_QQAY01000002.1:

Lassopeptides: DFR59_RS05045_lassopeptide

6

GYTKKTPNAIQ

16

G K TP+A+Q

1

GPGKATPDAVQ

11

23.8%

NZ_CM000754.1and 19 others:

NZ_CP020723.1 Lassopeptides: B7P25_RS28625_lassopeptideNZ_CP023179.1 Lassopeptides: CK938_RS28520_lassopeptideNZ_CP032365.1 Lassopeptides: D4A37_RS18780_lassopeptideNZ_CP041063.1 Lassopeptides: FJM75_RS10710_lassopeptideNZ_CP085399.1 Lassopeptides: LIS81_RS18060_lassopeptideNZ_FMBE01000013.1 Lassopeptides: CCY88_RS31005_lassopeptideNZ_FMJI01000046.1 Lassopeptides: CCY61_RS30520_lassopeptideNZ_FMZR01000002.1 Lassopeptides: BLS53_RS31385_lassopeptideNZ_FTLZ01000002.1 Lassopeptides: BW973_RS28715_lassopeptideNZ_JAIEZS010000055.1 Lassopeptides: K0820_RS18465_lassopeptideNZ_JH791975.1 Lassopeptides: IEI_RS31960_lassopeptideNZ_JH792165.1 Lassopeptides: IIO_RS35460_lassopeptideNZ_JYPF01000002.1 Lassopeptides: TU50_RS30650_lassopeptideNZ_NUFG01000001.1 Lassopeptides: CN694_RS29875_lassopeptideNZ_NURJ01000008.1 Lassopeptides: COE89_RS29040_lassopeptideNZ_PIYQ01000023.1 Lassopeptides: CW365_RS28935_lassopeptideNZ_QOSC01000009.1 Lassopeptides: DN392_RS14315_lassopeptideNZ_VDNI01000012.1 Lassopeptides: FSV62_RS19525_lassopeptideNZ_WBPF01000005.1 Lassopeptides: F8162_RS06315_lassopeptide

Lassopeptides: BTHUR0009_RS30905_lassopeptide

10

KTPNAIQ

16

KTP+A+Q

5

KTPDAVQ

11

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Transcription Factor Binding Sites

Binding sites found:

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 17.19 out of 19.26

Confidence: medium

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.71 out of 20.97

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.84 out of 26.06

Confidence: medium

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 24.81 out of 30.25

Confidence: medium

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 21.04 out of 24.78

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.52 out of 26.06

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.70 out of 26.06

Confidence: medium

Additional weak hits (4):

MatP

Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.27 out of 25.75

Confidence: weak

HipB

Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 22.23 out of 33.73

Confidence: weak

BldD

Description: Development and antibiotic global regulator
Species: Streptomyces coelicolor
Score: 19.16 out of 23.43

Confidence: weak

CelR

Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 20.04 out of 30.11

Confidence: weak

Lanthipeptides

TFBS Finder

Core peptide predictions

A1178_RS03085 - Class II

Cleavage pHMM score: -1.30

RODEO score: 0

Monoisotopic mass: 3741.0 Da

Molecular weight: 3743.2 Da

Number of bridges: 2

Alternative weights: (assuming N unmodified Ser/Thr residues); 3761.2 Da N = 1; 3779.2 Da N = 2; 3797.3 Da N = 3; 3815.3 Da N = 4; 3833.3 Da N = 5; 3851.3 Da N = 6; 3869.3 Da N = 7

A1178_RS03090 - Class II

Cleavage pHMM score: -0.40

RODEO score: 0

Monoisotopic mass: 4313.2 Da

Molecular weight: 4315.8 Da

Number of bridges: 2

Alternative weights: (assuming N unmodified Ser/Thr residues); 4333.9 Da N = 1; 4351.9 Da N = 2; 4369.9 Da N = 3; 4387.9 Da N = 4; 4405.9 Da N = 5; 4424.0 Da N = 6; 4442.0 Da N = 7

allorf_046199_046306 - Class II

Cleavage pHMM score: -6.50

RODEO score: 0

Monoisotopic mass: 1769.9 Da

Molecular weight: 1771.0 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 1789.1 Da N = 1

TFBS definitions

Regulator	Description
CRP	Cyclic AMP receptor protein
CcpA	Catabolite control protein A
ColR	Phenol-responsive regulator
LexA variant 2	Repressor of DNA damage response
MogR	Repressor of flagellar motility genes

NZ_FEOS01000008.1 - Region 1 - terpene-precursor

Download region GenBank file

Download region SVG

Location: 81,783 - 99,992 nt. (total: 18,210 nt) Show pHMM detection rules used

Region on contig edge.

terpene-precursor: (PT_FPPS_like and not PT_HPP)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Hydrolases: back translocase

A1178_RS06650: GTP-binding protein LepA

smcogs: SMCOG1190: GTP-binding protein LepA

Ligases: synthetase

A1178_RS06625: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002397.2	0.47	terpene	astallatene	Arabidopsis thaliana
BGC0002400.2	0.44	terpene	boleracene	Brassica oleracea var. oleracea
BGC0002398.2	0.38	terpene	(-)-ent-quiannulatene	Arabidopsis thaliana
BGC0001605.3	0.32	terpene	gibberellin	Sinorhizobium fredii NGR234
BGC0000648.3	0.31	terpene	carotenoid	Myxococcus xanthus
BGC0001456.3	0.30	terpene	isorenieratene	Streptomyces argillaceus
BGC0001756.3	0.28	terpene	retigeranin, arathanatriene	Arabidopsis thaliana
BGC0001594.3	0.27	other (other)	fischerindole L	Fischerella muscicola UTEX 1829
BGC0001595.3	0.26	other (other)	fischerindole	Fischerella sp. SAG 46.79
BGC0000668.5	0.26	other (other), terpene	12-epi-hapalindole C isonitrile, 12-epi-hapalindole E, 12-epi-fischerindole U isonitrile, fischerindole L, 12-epi-fischerindole I isonitrile, welwitindolinone A isonitrile, welwitindolinone B isothiocyanate, welwitindolinone C isothiocyanate, N-methylwelwitindolinone C isothiocyanate, N-methylwelwitinsolinone C isonitrile, 3-epi-welwitindolinone B isothiocyanate, 3-(Z-2'-isocyanoethenyl)-indole	Hapalosiphon welwitschii UTEX B 1830

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002397.2	0.47	terpene	astallatene	Arabidopsis thaliana
BGC0002400.2	0.44	terpene	boleracene	Brassica oleracea var. oleracea
BGC0002398.2	0.38	terpene	(-)-ent-quiannulatene	Arabidopsis thaliana
BGC0001605.3	0.32	terpene	gibberellin	Sinorhizobium fredii NGR234
BGC0000648.3	0.31	terpene	carotenoid	Myxococcus xanthus
BGC0001456.3	0.30	terpene	isorenieratene	Streptomyces argillaceus
BGC0001756.3	0.28	terpene	retigeranin, arathanatriene	Arabidopsis thaliana
BGC0001594.3	0.27	other (other)	fischerindole L	Fischerella muscicola UTEX 1829
BGC0001595.3	0.26	other (other)	fischerindole	Fischerella sp. SAG 46.79
BGC0000668.5	0.26	other (other), terpene	12-epi-hapalindole C isonitrile, 12-epi-hapalindole E, 12-epi-fischerindole U isonitrile, fischerindole L, 12-epi-fischerindole I isonitrile, welwitindolinone A isonitrile, welwitindolinone B isothiocyanate, welwitindolinone C isothiocyanate, N-methylwelwitindolinone C isothiocyanate, N-methylwelwitinsolinone C isonitrile, 3-epi-welwitindolinone B isothiocyanate, 3-(Z-2'-isocyanoethenyl)-indole	Hapalosiphon welwitschii UTEX B 1830

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
sesquiterpene precursor		FPP	C15	acyclic	PP

Genes with terpene domains:

A1178_RS06625: PT_FPPS_like

Domain 1 (27 - 272): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: Farnesyl diphosphate synthase, bacterial

Reactions:: IPP, DMAPP → FPP

Transcription Factor Binding Sites

Binding sites found:

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 19.52 out of 23.79

Confidence: medium

AfsR

Description: Pleiotropic regulatory for antibiotic production
Species: Streptomyces coelicolor
Score: 19.59 out of 23.05

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.39 out of 27.78

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 23.47 out of 28.19

Confidence: medium

Terpene

TFBS Finder

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
IPP	Isopentenyl diphosphate
PP	Diphosphate

TFBS definitions

Regulator	Description
AfsR	Pleiotropic regulatory for antibiotic production
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
IolR	Regulator of the inositol catabolism
ZuR variant 1	Zinc-responsive repressor

NZ_FEOS01000010.1 - Region 1 - T3PKS

Download region GenBank file

Download region SVG

Location: 25,403 - 66,575 nt. (total: 41,173 nt) Show pHMM detection rules used

T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: reductase

A1178_RS07435: hydroxymethylglutaryl-CoA reductase

smcogs: SMCOG1187: hydroxymethylglutaryl-CoA reductase

Transferases: formyltransferase methyltransferase phosphotransferase

A1178_RS07345: methyltransferase

smcogs: SMCOG1248: methyltransferase

A1178_RS07385: methionyl-tRNA formyltransferase

smcogs: SMCOG1228: methionyl-tRNA formyltransferase

A1178_RS07455: Glucose-specific phosphotransferase enzyme IIA

smcogs: SMCOG1145: Glucose-specific phosphotransferase enzyme IIA

Hydrolases: hydrolase

A1178_RS07335: isochorismatase

smcogs: SMCOG1027: isochorismatase

Ligases: synthase

A1178_RS07430: hydroxymethylglutaryl-CoA synthase

smcogs: SMCOG1043: hydroxymethylglutaryl-CoA synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002700.2	0.45	ribosomal	bacinapeptin	Bacillus nakamurai
BGC0000519.4	0.45	ribosomal	labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3	Actinomadura namibiensis
BGC0002111.3	0.42	ribosomal	andalusicin A, andalusicin B	Bacillus thuringiensis serovar andalousiensis NRRL B-23139
BGC0000558.5	0.42	ribosomal	sublancin 168	Bacillus subtilis subsp. subtilis str. 168
BGC0001521.3	0.41	NRPS	auriculamide	Herpetosiphon aurantiacus DSM 785
BGC0000486.4	0.41	ribosomal	butyrivibriocin AR10	Butyrivibrio fibrisolvens
BGC0002561.3	0.40	other (other)	phenazine SA, phenazine SB, phenazine SC	Streptomyces sp.
BGC0000592.5	0.40	ribosomal	microviridin B	Microcystis aeruginosa NIES-298
BGC0000616.4	0.40	ribosomal	amylocyclicin	Bacillus velezensis FZB42
BGC0000205.3	0.40	PKS	bryostatin	Candidatus Endobugula sertula

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002700.2	0.45	ribosomal	bacinapeptin	Bacillus nakamurai
BGC0000519.4	0.45	ribosomal	labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3	Actinomadura namibiensis
BGC0002111.3	0.42	ribosomal	andalusicin A, andalusicin B	Bacillus thuringiensis serovar andalousiensis NRRL B-23139
BGC0000558.5	0.42	ribosomal	sublancin 168	Bacillus subtilis subsp. subtilis str. 168
BGC0001521.3	0.41	NRPS	auriculamide	Herpetosiphon aurantiacus DSM 785
BGC0000486.4	0.41	ribosomal	butyrivibriocin AR10	Butyrivibrio fibrisolvens
BGC0002561.3	0.40	other (other)	phenazine SA, phenazine SB, phenazine SC	Streptomyces sp.
BGC0000592.5	0.40	ribosomal	microviridin B	Microcystis aeruginosa NIES-298
BGC0000616.4	0.40	ribosomal	amylocyclicin	Bacillus velezensis FZB42
BGC0000205.3	0.40	PKS	bryostatin	Candidatus Endobugula sertula

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 27.71 out of 27.78

Confidence: strong

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 23.40 out of 30.25

Confidence: medium

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 19.14 out of 20.97

Confidence: strong

Additional weak hits (5):

MntR

Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 25.02 out of 39.62

Confidence: weak

DosR

Description: Hypoxia stress response regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 23.25 out of 29.51

Confidence: weak

CopR

Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 23.25 out of 30.97

Confidence: weak

LuxO

Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 21.78 out of 26.12

Confidence: weak

NuR

Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 22.37 out of 30.98

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
CcpA	Catabolite control protein A
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
ColR	Phenol-responsive regulator

NZ_FEOS01000014.1 - Region 1 - RiPP-like

Download region GenBank file

Download region SVG

Location: 43,513 - 48,824 nt. (total: 5,312 nt) Show pHMM detection rules used

Region on contig edge.

RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

No tailoring functions detected.

Similar gene clusters

Analysis type:

Reference	RiPP-like	Similarity score	Type	Compound(s)	Organism
BGC0000119.5		0.19	PKS, saccharide	7-deoxypactamycin	Streptomyces pactum

Reference	Aggregated	Similarity score	Type	Compound(s)	Organism
BGC0000119.5		0.19	PKS, saccharide	7-deoxypactamycin	Streptomyces pactum

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 20.08 out of 24.78

Confidence: medium

TFBS Finder

TFBS definitions

Regulator	Description
LexA variant 2	Repressor of DNA damage response

NZ_FEOS01000026.1 - Region 1 - RiPP-like

Download region GenBank file

Download region SVG

Location: 14,697 - 20,969 nt. (total: 6,273 nt) Show pHMM detection rules used

Region on contig edge.

RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

No tailoring functions detected.

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000617.5	0.40	ribosomal	coagulin	Bacillus coagulans
BGC0002579.2	0.39	ribosomal	carnobacteriocin XY	Carnobacterium maltaromaticum
BGC0001887.3	0.38	ribosomal	huazacin	Bacillus thuringiensis serovar huazhongensis BGSC 4BD1
BGC0001388.3	0.35	ribosomal	gassericin E	Lactobacillus gasseri
BGC0000619.3	0.35	ribosomal	gassericin T	Lactobacillus gasseri
BGC0001602.3	0.35	ribosomal	gassericin-T	Lactobacillus gasseri
BGC0002577.2	0.35	ribosomal	lactococcin G	Lactococcus lactis
BGC0002306.2	0.34	ribosomal	freyrasin	Paenibacillus polymyxa ATCC 842
BGC0000624.3	0.33	ribosomal	salivaricin CRL1328 α peptide, salivaricin CRL1328 β peptide	Lactobacillus salivarius
BGC0000494.5	0.32	ribosomal	uberolysin	Streptococcus uberis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000617.5	0.40	ribosomal	coagulin	Bacillus coagulans
BGC0002579.2	0.39	ribosomal	carnobacteriocin XY	Carnobacterium maltaromaticum
BGC0001887.3	0.38	ribosomal	huazacin	Bacillus thuringiensis serovar huazhongensis BGSC 4BD1
BGC0001388.3	0.35	ribosomal	gassericin E	Lactobacillus gasseri
BGC0000619.3	0.35	ribosomal	gassericin T	Lactobacillus gasseri
BGC0001602.3	0.35	ribosomal	gassericin-T	Lactobacillus gasseri
BGC0002577.2	0.35	ribosomal	lactococcin G	Lactococcus lactis
BGC0002306.2	0.34	ribosomal	freyrasin	Paenibacillus polymyxa ATCC 842
BGC0000624.3	0.33	ribosomal	salivaricin CRL1328 α peptide, salivaricin CRL1328 β peptide	Lactobacillus salivarius
BGC0000494.5	0.32	ribosomal	uberolysin	Streptococcus uberis

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.71 out of 26.06

Confidence: medium

Additional weak hits (1):

LexA variant 3

Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 23.85 out of 32.93

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
MogR	Repressor of flagellar motility genes