LOCUS       NZ_FEOS01000014         5312 bp    DNA     linear   CON 12-DEC-2024
DEFINITION  Streptococcus pneumoniae strain 2842STDY5881910, whole genome
            shotgun sequence.
ACCESSION   NZ_FEOS01000014
VERSION     NZ_FEOS01000014.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1
  CONSRTM   Pathogen Informatics
  TITLE     Direct Submission
  JOURNAL   Submitted (04-FEB-2016) SC, Wellcome Trust Sanger Institute, CB10
            1SA, United Kingdom
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_900036145.1-RS_2024_12_12
            Annotation Date                   :: 12/12/2024 02:11:13
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.9
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 2,245
            CDSs (total)                      :: 2,193
            Genes (coding)                    :: 2,004
            CDSs (with protein)               :: 2,004
            Genes (RNA)                       :: 52
            rRNAs                             :: 2, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1, 1 (5S, 16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 45
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 189
            CDSs (without protein)            :: 189
            Pseudo Genes (ambiguous residues) :: 0 of 189
            Pseudo Genes (frameshifted)       :: 85 of 189
            Pseudo Genes (incomplete)         :: 105 of 189
            Pseudo Genes (internal stop)      :: 56 of 189
            Pseudo Genes (multiple problems)  :: 48 of 189
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 11:31:24
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 43512
            Orig. end                         :: 48824
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            FEOS01000014.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..5312
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RiPP-like"
                     /region_number="1"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..5312
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..5312
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[5000:5150](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..5150)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     gene            complement(244..879)
                     /gene="trmB"
                     /locus_tag="A1178_RS08670"
                     /old_locus_tag="ERS515165_01708"
     CDS             complement(244..879)
                     /EC_number="2.1.1.33"
                     /GO_function="GO:0008176 - tRNA
                     (guanine(46)-N7)-methyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0006400 - tRNA modification [Evidence IEA]"
                     /codon_start=1
                     /gene="trmB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001266107.1"
                     /locus_tag="A1178_RS08670"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS515165_01708"
                     /product="tRNA (guanosine(46)-N7)-methyltransferase TrmB"
                     /protein_id="WP_001266083.1"
                     /transl_table=11
                     /translation="MRVRNRKGATELLEANPQYVVLNPLEAKAKWRDLFGNDNPIHVEV
                     GSGKGAFVSGMAKQNPDINYIGIDIQKSVLSYALDKVLEVGVPNIKLLWVDGSDLTDYF
                     EDGEIDRLYLNFSDPWPKKRHEKRRLTYKTFLDTFKRILPENGEIHFKTDNRGLFEYSL
                     VSFSQYGMKLNGVWLDLHASDFEGNVMTEYEQKFSNKGQVIYRVEAEF"
     gene            complement(876..1670)
                     /gene="ccrZ"
                     /locus_tag="A1178_RS08675"
                     /old_locus_tag="ERS515165_01709"
     CDS             complement(876..1670)
                     /EC_number="2.7.1.15"
                     /EC_number="2.7.1.229"
                     /GO_function="GO:0004747 - ribokinase activity [Evidence
                     IEA]"
                     /GO_function="GO:0016773 - phosphotransferase activity,
                     alcohol group as acceptor [Evidence IEA]"
                     /GO_function="GO:0019200 - carbohydrate kinase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006270 - DNA replication initiation
                     [Evidence IEA]"
                     /GO_process="GO:0051726 - regulation of cell cycle
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="ccrZ"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) APH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000363010.1"
                     /locus_tag="A1178_RS08675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS515165_01709"
                     /product="cell cycle regulator CcrZ"
                     /protein_id="WP_000363002.1"
                     /sec_met_domain="APH (E-value: 1.2e-19, bitscore: 63.1,
                     seeds: 156, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDLGDNELTLTPIPGKSGKAYMGSYPDGKRIFVKMNTSPILPGLA
                     REQIAPQLLWSRRLADGRDMCAQEWLTGKILTPYDMNRKQIVNILTRLHRSRPLMTQLS
                     RLGYAMETPVDLLQSWQETAPDALRKNHFISEVMADLRQTIPGFREDHATIVHGDVRHS
                     NWIETDSGLIYLVDWDSVRLTDRMFDVAHMLCHYISEHQWKEWLTYYGYKYNQTVLSKL
                     YWYGQLSYLSQISKYYMNQDLENVNREIHGLRHFRDKYGKRR"
     gene            complement(1832..2443)
                     /locus_tag="A1178_RS08680"
                     /old_locus_tag="ERS515165_01710"
     CDS             complement(1832..2443)
                     /EC_number="3.4.-.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abi"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000394041.1"
                     /locus_tag="A1178_RS08680"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS515165_01710"
                     /product="CPBP family intramembrane glutamic endopeptidase"
                     /protein_id="WP_044814721.1"
                     /sec_met_domain="Abi (E-value: 2.1e-21, bitscore: 68.2,
                     seeds: 823, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEFFDKFHALCFGFLVLIIVITVPYTINHGDFFQNESALIIVSLL
                     VTSLSVAYARKFEMISFGMLSKKQLLLFIAIFLLSVLETLVYIHFFAVSSGSGVQHLAE
                     VSRGISLSLILTTSVFGPIQEELIFRGLLQGAVFDNSWLGLVLTSSLFSFMHGPSNVPS
                     FIFYLLGGLLLGFAYKKSQNLWVSTLVHMLYNSWPLLTYL"
     gene            complement(2594..2826)
                     /gene="blpZ"
                     /locus_tag="A1178_RS13520"
                     /pseudo=""
     CDS             complement(2594..2826)
                     /codon_start=1
                     /gene="blpZ"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000276505.1"
                     /locus_tag="A1178_RS13520"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="immunity protein BlpZ"
                     /pseudo=""
                     /transl_table=11
                     /translation="MYKHLFF"
     gene            complement(2868..3557)
                     /locus_tag="A1178_RS08690"
                     /old_locus_tag="ERS515165_01711"
     CDS             complement(2868..3557)
                     /EC_number="3.4.-.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abi"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000760553.1"
                     /locus_tag="A1178_RS08690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS515165_01711"
                     /product="CPBP family intramembrane glutamic endopeptidase"
                     /protein_id="WP_050119095.1"
                     /sec_met_domain="Abi (E-value: 2.1e-15, bitscore: 49.0,
                     seeds: 823, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKYQLLFKISAVFSYLFFVFGLSQLTLIVQNYWQFSSQIGNFVW
                     IQNILSLLFSGVMIWILAKTGHGYLFRIPRKKWLWYSILTVLVLVLHISFNVQIAKHVQ
                     STAEGWAVLIGYSGTNFAELGIYVTLFFLTPLMEELIYRGLLQHAFFKHSRFGLDLFLP
                     SILFALPHFSRLPSLLDIFVFATFGIIFAGLTRYTKSIYPSYAVHVINNIVATFPFLLT
                     FLHRVLG"
     gene            complement(3609..3992)
                     /locus_tag="A1178_RS08695"
                     /old_locus_tag="ERS515165_01712"
     CDS             complement(3609..3992)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398494.1"
                     /locus_tag="A1178_RS08695"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS515165_01712"
                     /product="hypothetical protein"
                     /protein_id="WP_016398494.1"
                     /transl_table=11
                     /translation="MKYRLFFVIFLSSVLDILLGTFLQISIVSIGWLVLYSGLFEAGVF
                     LLANKGVAVKIKEVDIRNRFKFIFGKTLWFQILLLIFLIIKLYLGLDARLILFYGHIFI
                     VFNVLMYLLSSSQVSLKKNKLSS"
     gene            complement(4075..>4265)
                     /locus_tag="A1178_RS13895"
                     /pseudo=""
     CDS             complement(4075..>4265)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000846948.1"
                     /locus_tag="A1178_RS13895"
                     /note="frameshifted; incomplete; partial in the middle of a
                     contig; missing N-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /product="hypothetical protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="DDLVSPRTNQLMLIGLADFMFVICLYRGISETEFYQQLIAYIGVF
                     SACLSRFCSCGA"
     misc_feature    4629..4642
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: medium, score: 20.08"
                     /tool="antismash"
     gene            complement(4778..4897)
                     /locus_tag="A1178_RS08705"
     CDS             complement(4778..4897)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000346296.1"
                     /locus_tag="A1178_RS08705"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="PncF family bacteriocin immunity protein"
                     /protein_id="WP_000346296.1"
                     /transl_table=11
                     /translation="MDFKSFIIGLVVGIFGPYMDDLIRKIFSKSSKKDTDSTL"
     gene            complement(4900..>4965)
                     /locus_tag="A1178_RS14000"
                     /pseudo=""
     CDS             complement(4900..>4965)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001863320.1"
                     /locus_tag="A1178_RS14000"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="ComC/BlpC family peptide pheromone/bacteriocin"
                     /pseudo=""
                     /transl_table=11
                     /translation="VTGAAGGAILGGVAYAATCWW"
     gene            complement(5001..5150)
                     /gene="blpO"
                     /locus_tag="A1178_RS08710"
                     /old_locus_tag="ERS515165_01713"
     CDS             complement(5001..5150)
                     /codon_start=1
                     /gene="blpO"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Bacteriocin_IIc"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001818346.1"
                     /locus_tag="A1178_RS08710"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS515165_01713"
                     /product="bacteriocin-like peptide BlpO"
                     /protein_id="WP_001818346.1"
                     /sec_met_domain="Bacteriocin_IIc (E-value: 1.5e-11,
                     bitscore: 36.5, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDTKMMSQFAVMDNEMLACVEGGDIDWGRKISCAAGVAYGAIDGC
                     ATTV"
ORIGIN
        1 tgagaatcat gtcactgcca atctttccat actcgatatc cacgagttca aaaggagctt
       61 ctatgacagg ttctacaact tctctgacta attctacgat tgttgcgatt gcgtccacct
      121 cctcataagc aagaggcgaa gatatttccc cgcctcactt ttcatattct tactatcagt
      181 atagcacgtt tgccaactta tgtaaagcaa aagcacttgt acagcctaat tttaggctat
      241 ctcttaaaat tctgcctcaa ctcggtagat aacttgcccc ttgtttgaga atttttgctc
      301 gtattctgtc atgacattgc cttcaaaatc actggcatgc aaatctagcc agacaccatt
      361 gagtttcatg ccatattgag aaaagctcac taaactgtac tcaaacaagc cacggttatc
      421 cgtcttgaaa tgaatttctc cattttcagg caagatacgt ttgaaggtgt ccaaaaaggt
      481 cttgtaggtc aaacgacgct tttcatggcg ttttttcggc catggatctg aaaagttcag
      541 atacaagcga tcaatctcac cgtcttcaaa gtagtcagtc aagtcagaac catctaccca
      601 caagagcttg atgttaggca ctccaacttc aagcaccttg tccaaagcgt agctcaaaac
      661 agacttttga atatcaatcc cgatatagtt gatgtcaggg ttttgcttgg ccatacctga
      721 aacaaaggca ccctttccac ttccaacttc cacatgaatg ggattatcat tgccaaacaa
      781 gtcccgccat tttgccttgg cttccaaggg attgaggacc acatactggg gatttgcctc
      841 tagtaattct gttgcccctt tacgatttct aactctcatc ttctctttcc atacttgtct
      901 cggaaatgac gcaaaccatg aatctcccga ttgacatttt ctaaatcttg gttcatataa
      961 tacttggaaa tctgactcaa ataagacaat tgaccatacc aatacaattt acttaatacc
     1021 gtttgattgt acttgtaacc gtagtaggtc aaccattcct tccactgatg ttctgaaata
     1081 taatggcaga gcatatgggc cacatcaaac atgcgatcgg tcaagcgaac cgaatcccaa
     1141 tctactaaat aaatcaagcc actatctgtc tcaatccaat tactatgtcg tacatctcca
     1201 tggacaatgg tcgcatggtc ctctctaaat cctggaatag tctgacgtaa atcagccatc
     1261 acttcactga taaaatgatt tttacgcaaa gcatctggag ccgtttcttg ccaagactgt
     1321 agtaaatcta caggtgtttc catggcatag cccaaacgac tcaattgtgt catcaacgga
     1381 cgtgagcgat gaagacgggt taaaatattg acgatttgct tacgattcat atcatagggg
     1441 gtcaatatct tgcctgtcaa ccattcttga gcacacatat cacgcccatc tgccaaacga
     1501 cgactccata ataattgtgg agcaatttgt tctctagcta gaccaggtag gattggagag
     1561 gtgttcattt ttacaaagat gcgcttccca tcaggatagc tacccatata agccttgcca
     1621 cttttcccag gtatgggagt cagtgttagc tcattatcac ccaaatccat ttctttcctc
     1681 cgtataaagt ttccttacta ttctactagt ttttggccta ttcgtcaacc actctaaccc
     1741 gattctcaaa gaaaagcctc tggagtggtt tgggttatca ttatagaaag aaaaaggtaa
     1801 gcacaatctc ctacttacct tttcatgatt tttataaata agttaagagt ggccaactgt
     1861 tgtaaagcat atggactaga gtagaaaccc ataggttttg actcttttta taagcaaagc
     1921 ccagcaacaa acccccaagt agataaaaaa taaacgaagg gacattagaa ggtccatgca
     1981 tgaaagaaaa gagagaggaa gttagcacaa gccctaacca agaattgtca aaaaccgcac
     2041 cttgaagaag tcctctgaaa atgagttcct cctggatggg gccaaaaact gaggtagtta
     2101 aaatcaaaga cagggaaatt cctctgctga cttccgccaa gtgttggacc cctgagccag
     2161 aagaaacagc gaagaaatga atataaacca gcgtctcaag tacacttaga agaaagattg
     2221 caatgaaaag caaaagttgt ttcttgctta acatcccaaa agaaatcatt tcaaactttc
     2281 tagcataagc aacactcagc gaggttacaa gaagacttac aataatcaat gcagattcat
     2341 tttgaaaaaa atccccatgg ttaatcgtat aaggaactgt aatgacaatt attagtacta
     2401 aaaatccaaa acacaaggca tgaaatttat caaaaaactc cataaaatta tcctcctcaa
     2461 caaacagact tcctacatgt cattctttag ttctagcctt tccaaaacaa accattttat
     2521 actcttcgaa aatcaaattc aaaccacgtc aacgtctcct tgccgtactc aagtacagcc
     2581 tgcggctagt ttcctagttt gctctttgat tttcattgag tattagtaac caaaatccga
     2641 ccacatagcc agctcctaag aagatagcca ttaaagctag catggaattt aggaaattaa
     2701 aaaccaccgc agatacaaag gttagcacaa aaacattaaa agcaatggtg tcagaagcca
     2761 agactagaat atagggtgtc aaccgatcta aagttttgga atctagaaaa ataagtgttt
     2821 atacatgatg acctcctcta tggctgaaaa gcaagccttt tgttttttta ccccaagacc
     2881 ctatgtagaa aagtgagcaa aaacgggaag gttgctacaa tattattgat cacatgcacc
     2941 gcataggatg gataaatact cttggtatag cgggtcaaac cggcaaagat gattccaaat
     3001 gttgcaaaga cgaaaatatc taacaaacta ggtaggcgtg aaaaatgagg aagagcaaat
     3061 aaaatggacg gaagaaacaa atcaaggcca aatcgcgaat gcttaaagaa ggcgtgttgc
     3121 agtaatcccc tataaatcaa ctcttccatt agtggagtca agaaaaacag ggttacatag
     3181 atacctagct cagcaaagtt ggtcccacta taaccgatca atacggccca accttcagca
     3241 gttgactgaa catgtttagc tatctgaacg ttaaaagaga tatggagcac tagcactaat
     3301 actgtcaaaa tcgaatacca aagccatttt tttcttggaa tgcgaaagag atagccatgg
     3361 cctgtcttag ccagaatcca aatcatgact ccgctaaata gtaaactcaa gatattttga
     3421 atccagacga aattgccaat ctgggaagaa aattgccaat aattttggac gataagcgtc
     3481 agctgagaaa gaccaaatac gaaaaataag taagagaaga ctgcacttat tttgaataga
     3541 agttgatact ttttcataga aattcttcct actatgacct caccttgtca ggctctactg
     3601 ctgtaagatt aagaagacag tttgttcttt ttaaggctaa cctgactact agataataga
     3661 tacattaaga cattaaagac aatgaaaata tgtccataga ataaaatcaa cctcgcatcc
     3721 aaaccaagat aaagtttgat tatcaaaaag atgagcaaaa gaatttgaaa ccataaggtt
     3781 tttccaaaaa taaatttgaa tcgatttcga atatctactt ccttgatttt taccgccacc
     3841 cctttattag caagaaggaa aactcctgct tcaaacaaac cactgtaaag aacaagccac
     3901 ccaatagata cgatagagat ttgtaaaaat gtccctaaaa gaatatccaa cacactactc
     3961 aagaaaataa caaaaaataa tctgtatttc atattaaata cctccattca tttatttcac
     4021 taacaattta atagagcctt ctactcaaat atcctgtcag aaaaggatag aaagctactt
     4081 tttataatac ttcaagcccc acatgagcag aagcgtgata aacaagcaga gaatacacct
     4141 atataagcga ttagttgttg atagaattct gtttctgaaa tacctctata caaacaaatg
     4201 acaaacataa aatctgccaa gccgataagc ataagttgat tggttctagg actaaccaaa
     4261 tcatcactta cttatattta agagtatctc ttttatgtta atgtatgtta gcactgaaaa
     4321 gcaagacaga ccaataatat ttaaaatgaa cagtaacggg gttaagtctc taaaaaaatt
     4381 atctactgac actacaagaa atactataca tattatagtc gaaactatct ttttcttatc
     4441 cataattatt tactcctttc ctaacaaatc cagcttatca atcaagagcg atttttaaca
     4501 taatgtagca gcacccgttg caactttgac aagtttagta tatcattgtt ttttaaaatt
     4561 tttcatccaa atcttgaatt gtcatcgaaa catcttgaat tgttaaaaaa tttaaaaagt
     4621 aagcattaaa aacatacttt cctctttata ttgtattgat accaacttgt ttgtagactt
     4681 ttcatcctgc tatcacatat cattttgaca ggcgaaacaa tattaaagaa actcccctgt
     4741 aaattaagct agcaaataca ggggagaaat ttatttttta gagagtacta tccgtatcct
     4801 ttttggaaga ttttgaaaat atttttctaa ttaagtcatc catataagga ccaaatatac
     4861 caactactaa accaataata aaacttttaa aatccataat taccaccaac atgtcgctgc
     4921 ataggccaca cctccaagta tagctcctcc cgcagcacca gttacaccta ttcctatagc
     4981 aaatggtccc aatagaaatg tcaaaccgtt gttgcacacc catcaattgc gccatatgca
     5041 acccctgctg cacaactaat ttttcttccc caatcaatat ctccaccttc aacgcaagca
     5101 agcatttcat tatccataac tgcaaattgt gacatcattt ttgtatccat atagtatatc
     5161 acttttcagt tacggaacaa gtttaatata aaaattatca aaaaaacata ggcaataaag
     5221 agaaaatgaa agttctataa tgaagttagc caccttacct tagtcaagaa ttagatgttt
     5281 cactatgttt gagtaagttg atgatttcat tt
//
