LOCUS       NZ_FEOS01000002        22610 bp    DNA     linear   CON 12-DEC-2024
DEFINITION  Streptococcus pneumoniae strain 2842STDY5881910, whole genome
            shotgun sequence.
ACCESSION   NZ_FEOS01000002
VERSION     NZ_FEOS01000002.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1
  CONSRTM   Pathogen Informatics
  TITLE     Direct Submission
  JOURNAL   Submitted (04-FEB-2016) SC, Wellcome Trust Sanger Institute, CB10
            1SA, United Kingdom
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_900036145.1-RS_2024_12_12
            Annotation Date                   :: 12/12/2024 02:11:13
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.9
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 2,245
            CDSs (total)                      :: 2,193
            Genes (coding)                    :: 2,004
            CDSs (with protein)               :: 2,004
            Genes (RNA)                       :: 52
            rRNAs                             :: 2, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1, 1 (5S, 16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 45
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 189
            CDSs (without protein)            :: 189
            Pseudo Genes (ambiguous residues) :: 0 of 189
            Pseudo Genes (frameshifted)       :: 85 of 189
            Pseudo Genes (incomplete)         :: 105 of 189
            Pseudo Genes (internal stop)      :: 56 of 189
            Pseudo Genes (multiple problems)  :: 48 of 189
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 11:31:24
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 174526
            Orig. end                         :: 197136
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            FEOS01000002.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22610
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-iv"
                     /region_number="1"
                     /rules="(cds(LANC_like and Pkinase) and not micKC)"
                     /tool="antismash"
     cand_cluster    1..22610
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(cds(LANC_like and Pkinase) and not
                     micKC)"
                     /kind="single"
                     /product="lanthipeptide-class-iv"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22610
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12610](-)"
                     /cutoff="20000"
                     /detection_rule="(cds(LANC_like and Pkinase) and not
                     micKC)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iv"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12610)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(cds(LANC_like and Pkinase) and not
                     micKC)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iv"
                     /protocluster_number="1"
     gene            complement(<187..583)
                     /locus_tag="A1178_RS12975"
                     /pseudo=""
     CDS             complement(<187..583)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000645893.1"
                     /locus_tag="A1178_RS12975"
                     /note="internal stop; incomplete; missing C-terminus;
                     Derived by automated computational analysis using gene
                     prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MKALNKESILDCDELETELHDAEIKQLDEQIFLMPNYPCEFEVTF
                     LDDYHKKHNYPLFYESYLQNVMEFLESQDIKNGVNAFVDDNQNLVFVLY"
     gene            complement(567..1925)
                     /gene="dcm"
                     /locus_tag="A1178_RS02355"
                     /old_locus_tag="ERS515165_00462"
                     /pseudo=""
     CDS             complement(567..1925)
                     /GO_function="GO:0003886 - DNA
                     (cytosine-5-)-methyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0006304 - DNA modification [Evidence IEA]"
                     /codon_start=1
                     /gene="dcm"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014947343.1"
                     /locus_tag="A1178_RS02355"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="ERS515165_00462"
                     /product="DNA (cytosine-5-)-methyltransferase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MWVLDLFAGIGGFRMGMEAQGHECLGFCEIDKFARKSYKSIFQTE
                     GEIEFHDIRDVSDDEFKKLRGKVDVICGGFPCQAFSIAGRRLGFEDTRGTLFFEIARAA
                     KQIQPRFLFLENVKGLLNHDKGRTFTTILTTLDELGFDVEWQVLNSKDFGVPKNRERVF
                     IIGHSRKKGTRLLFPFRREGQATNSETLKALGNLNPSRSGMSGKVYYSEGLAPTLVRGK
                     GEGFKVAIPCMTPDRLDKRQNGRRFKENQEPMFTLNTQDRYGIVVVGDLPTSFKETGRV
                     YGSEGLSPTLTTMQGGDKIPKILIPEPIQFLKVREATKKGYAQAEIGDSINLERPSSQY
                     RRGRVGKGIANTLTTSGQMGVVVASYEGEDKQVYQVAGVLIDGQFYRLRIRRITPKECF
                     RLHGFPD"
     gene            complement(2110..3456)
                     /locus_tag="A1178_RS02360"
                     /old_locus_tag="ERS515165_00463"
     CDS             complement(2110..3456)
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001808790.1"
                     /locus_tag="A1178_RS02360"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS515165_00463"
                     /product="IS1380-like element ISSpn5 family transposase"
                     /protein_id="WP_001808790.1"
                     /transl_table=11
                     /translation="MNSLPNHHFQNKSFYQLSFDGGHLTQYGGLIFFQELFSQLKLKER
                     ISKYLVTNDQRRYCRYSDSDILVQFLFQLLTGYGTDYACKELSADAYFPKLLEGGQLAS
                     QPTLSRFLSRTDEETVHSLRCLNLELVEFFLQFHQLNQLIVDIDSTHFTTYGKQEGVAY
                     NAHYRAHGYHPLYAFEGKTGYCFNAQLRPGNRYCSEEADSFITPVLERFNQLLFRMDSG
                     FATPKLYDLIEKTGQYYLIKLKKNTVLSRLGDLSLPCPQDEDLTILPHSAYSETLYQAG
                     SWSHKRRVCQFSERKEGNLFYDVISLVTNMTSGTSQDQFQLYRGRGQAENFIKEMKEGF
                     FGDKTDSSTLIKNEVRMMMSCIAYNLYLFLKHLAGGDFQTLTIKRFRHLFLHVVGKCVR
                     TGRKQLLKLSSLYAYSELFSALYSRIRKVNLNLPVPYEPPRRKASLMMH"
     misc_feature    3493..3510
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 23.05"
                     /tool="antismash"
     gene            complement(4077..4214)
                     /locus_tag="A1178_RS12595"
                     /old_locus_tag="ERS515165_00464"
     CDS             complement(4077..4214)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004264816.1"
                     /locus_tag="A1178_RS12595"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS515165_00464"
                     /product="hypothetical protein"
                     /protein_id="WP_000718654.1"
                     /transl_table=11
                     /translation="MAAEVLNLQLVSVQVDETDEVDGMRFSTFSTNRCGNWSAFSWENC
                     "
     gene            complement(4347..5666)
                     /locus_tag="A1178_RS02370"
                     /old_locus_tag="ERS515165_00465"
     CDS             complement(4347..5666)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000945307.1"
                     /locus_tag="A1178_RS02370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS515165_00465"
                     /product="FtsX-like permease family protein"
                     /protein_id="WP_000945311.1"
                     /transl_table=11
                     /translation="MLRLVYYQFLHNKKQWLGVSPVIFVSSLVMGLAVNGVINVENNSQ
                     VFVGLPDPKPIFMFPIVFGGVTLFFVLSNIINMLVEIFRDDYELLEVLGASRLQLSFLV
                     GGQIFIISSIISFIAYLCSIFVTSNYYYFLQYFFGENILPDIQFQTSAVGCIITVVLIS
                     FLAFLSGCFYTFKKIRNRKSSKIRHVLSIVKRILLLAGFSVIWLLSLQQIFQDSTILAK
                     AQIIFNIVILDIVIIYQLSPFIQSCFIKLLSIIIFRNNFMFIVSKWNLLYCKSYIKSIS
                     AAITGAILLISSFQMISQNILSQFQDDSDLELKVAFIVYVGAPILIVLANIISIAFLSS
                     HQERIEIQQFEILGTSNYQMVKIKVGEAIFLTFVTSLIAFLLNIKIMALIYYSLEDILI
                     DDMNLLGLILPNFIVSIILFILIFITKSSYFIFKNAKIIS"
     gene            complement(5669..6409)
                     /locus_tag="A1178_RS02375"
                     /old_locus_tag="ERS515165_00466"
     CDS             complement(5669..6409)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000356590.1"
                     /locus_tag="A1178_RS02375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS515165_00466"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_000356590.1"
                     /transl_table=11
                     /translation="MDKDYILKVKGLYHQFLLGNNKTLQVLKNVSLSASRGEFISILGI
                     SGSGKSTLLKCISSLLEPTSGEVILNGINPYKIRNAKLSSIRRNEVSFIFQAYNLIPSL
                     PVIENIALPLRLSQKKLTIKNVENLLKRMKFNAGLNDFVGTLSGGEQQKVAIARAVIAD
                     SDIIFADEPTGALDSVSREVIFELLRELVGAGKCVIMVTHDIELASKTDRALILKDGKI
                     FKELHRPSGEELYKILEVQSTTEE"
     gene            complement(6424..8031)
                     /locus_tag="A1178_RS11580"
                     /old_locus_tag="ERS515165_00467"
     CDS             complement(6424..8031)
                     /EC_number="7.-.-.-"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001866765.1"
                     /locus_tag="A1178_RS11580"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS515165_00467"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_001108416.1"
                     /transl_table=11
                     /translation="MNYLKFIKKTKLILMGILIFLSSFNGVLLSGIIVYAGSLNQTSSF
                     SDVLRFGAISILGWSAIYISNYYLEVTEASITKDINVKIKQGYFREQYLSSEMVKDYSS
                     IISVLSNDLRLIEENYFRQIFEIISSILLFIVSLSFMLYLNFLVSIIFIVLSALPIIVP
                     VFMKKMLSNSANEYSNSNAEYTHIIKEIFNGFKTLKSYSVTKEIISLSDKKLDKLEDST
                     FNLKRSEVLSKLVAVLISGFCFLVPLVVGCYFVIYHKSLSFSELIGIFLANDKVLGPIQ
                     SIAYSLNKINTTKDLRKPFLKYLSGEKNFIDAEHDNNGLYTSSIDEIHMKDVVYSITPE
                     NKLSIDFSFKSPFRVLLTGTSGSGKTTILNLINGSLKPQKGYVNLLSHGKKSSDSIPTV
                     DQTPYIFDTTIRENVTLFQNEYFSDDQIIEVLKKVNLYEELEKIDILNYQCGENGSNLS
                     GGQKQKIALARALIRNNKVYLFDEISANLDNDNSNSIHDILFNLGISFIEVSHHYDLND
                     KRYTDIYKLENGTLFKIK"
     gene            complement(8028..9968)
                     /locus_tag="A1178_RS02385"
                     /old_locus_tag="ERS515165_00468"
     CDS             complement(8028..9968)
                     /GO_function="GO:0008236 - serine-type peptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S9"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004263477.1"
                     /locus_tag="A1178_RS02385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS515165_00468"
                     /product="prolyl oligopeptidase family serine peptidase"
                     /protein_id="WP_001076600.1"
                     /sec_met_domain="Peptidase_S9 (E-value: 1.1e-32, bitscore:
                     107.2, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNQSNEIFLNTIQEKTHYKRSISSSFQELKKWNSLIFRRGRYWYQ
                     FDNWSIPNTGVIKEWYVEDNDWIPKVSSSSLDNSNSLKIVFDVEKYTLPDDSILQDVRI
                     SSDESYIVLVVSSLRSTNLIGIKKYTMEELFIIEDISVESSFYLGKFGVMYTRSKEYGR
                     PSKLFYKSFDSFTEEELFEENECSFRLKIVHIDSNNCFVKSVDFQKGRIFLYSFDRTGF
                     VRHSYTETVAPTPRDIALFSTEKAQYFLGLSSTEEKKDQLILRETSSGDRVSITIPYQD
                     RARRVHCIGRYILLDCSNAANSVFYLATFKNNSLRELSVNKITFDEKTTLYENSFSDRV
                     LLFLERRTFYEKILSFDLIENTLKTEFERPIIKSNNTKYFSKVIWTKKDSYDVSIPISL
                     FWKSEDTDELPRRKKCILSVYGAYGKNDNSDLDEIMLSIIDAGFIYAIVHVRGGGYLGG
                     EWYRSGKALNKWNSIRDFIEGVNYLRENDVIDSKRLGLITSSAGGIIAGAVLNEEKNLL
                     QSILLFSPFINPYDTLQNPNDPLSKTEIAEWGDIRDPEVKAYIKSYSPMQNIEKARDSN
                     TVIVNILGEKDPYINNNEVIEWSKKLNSIGVKSLLYLNKAAGHGGFTPSDVLLMIDTLN
                     YFFEEVGRNNL"
     gene            complement(10001..12610)
                     /locus_tag="A1178_RS02390"
                     /old_locus_tag="ERS515165_00469"
     CDS             complement(10001..12610)
                     /GO_process="GO:0031179 - peptide modification [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-iv: LANC_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-iv: Pkinase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000386153.1"
                     /locus_tag="A1178_RS02390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS515165_00469"
                     /product="lanthionine synthetase LanC family protein"
                     /protein_id="WP_000386154.1"
                     /sec_met_domain="Pkinase (E-value: 4.2e-09, bitscore: 30.1,
                     seeds: 54, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 1.6e-14, bitscore:
                     47.4, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDYNFNLEHPFFFTNNDYSTDTSIKYQVSLPFNWHEVMNNDEWVY
                     QYPIGKFVERQGWKIHISSEYNSSHELLQDVAKICHEMRIPFKHLSTEDKFIMRNGKLV
                     SRGFSGKFITCYPNQNELESVLQRLESALKQYNGPYILSDKRWDEAPIYLRYGVFRPSR
                     DDEKKVAIDELIVGDEVVKDERLPVFKIPKGIVPPDFLNKWLDKKDKKQGDFPFIIDNA
                     IRFSNSGGIYNARLKEDGKKIILKEARPYTGLGFDGTYSSERLASECKALKILNEWSET
                     PKIYWHGKIWEHTFLGIEHMKGVPLNRWVTNNFPLYEVVDKTKDYLLRVSKIVEKLIDL
                     TNKFHSENVYHQDLHLGNILVKDEDEISIIDWEQAVFSNDEKVVHKVAAPGFRAWRETL
                     PSEIDWYGIRQIAHYLYMPLVTTSDLTYNYVSQTRIEGKKLFESLGYTREHIDYVESLL
                     SYLDSKCPQIENISRKKVLKPMHEIRTIESEQDIQDFIIKLLRGFTLTYGQWRKEFQSR
                     FFPVHYYGLNFNQGIAFSDLAILWSYQQLAKKVKNFKFDDYYEIRTQVINEAVNNFKKS
                     SLSGLFDGKIGTIWLIYEFGEIDRAVELFTTHFIEIFENSQNKNLYSGQAGILLVGLYF
                     LSKGGIDNKLGEEILIRLREYTLNYIENPETFCKVGASDVQSNDPYENFGGLLYGHAGV
                     AWLFGEAYKLTGESIYKNGLELAVDKELVAYKVDSNNSLQYSQGHRLLPYLATGSAGLL
                     LLINRNKEILSSKYLKYLTSLERATDVVFCVLPGLFNGFCGLEVANNIYSDIDDNFSGQ
                     KKLIEQLYRYLCVIEEGFVIAGDNGLKITTDIASGFAGVAIGLVSIMDNKLTILPQI"
     gene            complement(12789..12926)
                     /locus_tag="A1178_RS12600"
                     /old_locus_tag="ERS515165_00470"
     CDS             complement(12789..12926)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004264816.1"
                     /locus_tag="A1178_RS12600"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS515165_00470"
                     /product="hypothetical protein"
                     /protein_id="WP_000807141.1"
                     /transl_table=11
                     /translation="MAEEVLNLQLVSVQVDETDEVDGMRFSTFSTNRCGNWSAFSWENC
                     "
     gene            complement(13128..13715)
                     /locus_tag="A1178_RS02395"
                     /old_locus_tag="ERS515165_00471"
     CDS             complement(13128..13715)
                     /EC_number="3.4.-.-"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0070007 - glutamic-type endopeptidase
                     activity [Evidence IEA]"
                     /GO_process="GO:0071586 - CAAX-box protein processing
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abi"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000821297.1"
                     /locus_tag="A1178_RS02395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS515165_00471"
                     /product="CPBP family intramembrane glutamic endopeptidase"
                     /protein_id="WP_061839586.1"
                     /sec_met_domain="Abi (E-value: 1.4e-14, bitscore: 48.3,
                     seeds: 823, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKRIIPVYIFQQVNVLLVSLYLLKFLCIGELTILQILYGSSLISF
                     LWMYGQRKQAHKVNMKSRMKWLGIGLASLLIISLCFSLIHAQESTNQANLIGLQHQVPW
                     FSFLLFLINASMVEEFLYREILWNLVRKLDIRVALTSVLFALAHHPGTIIAWCLYVSLG
                     MFLGLVRYKLDLWGSMGLHLVWNLLVYSLLLF"
     gene            complement(13808..13951)
                     /locus_tag="A1178_RS13955"
                     /old_locus_tag="ERS515165_00472"
     CDS             complement(13808..13951)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000840765.1"
                     /locus_tag="A1178_RS13955"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS515165_00472"
                     /product="hypothetical protein"
                     /protein_id="WP_000840766.1"
                     /transl_table=11
                     /translation="MAERFWENLSIILAERNISCIELTRKMFAGEFHYPSELNRLYQKI
                     RH"
     assembly_gap    14061..14378
                     /estimated_length=318
                     /gap_type="unknown"
                     /linkage_evidence="unspecified"
     gene            complement(<14379..14649)
                     /locus_tag="A1178_RS02400"
     CDS             complement(<14379..14649)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000645893.1"
                     /locus_tag="A1178_RS02400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_078376769.1"
                     /transl_table=11
                     /translation="MTFLDDYHKKHNYPLFYESYLQNVMEFLESQDIKNGVDAFVDDHQ
                     NLVFVLYGQGYRAEGKEGILTTQVTVKAYDEDKKPINFANLLDSL"
     misc_feature    14645..14660
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: weak,
                     score: 16.79"
                     /tool="antismash"
     gene            complement(<14660..14911)
                     /locus_tag="A1178_RS02405"
                     /old_locus_tag="ERS515165_00473"
                     /pseudo=""
     CDS             complement(<14660..14911)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017648301.1"
                     /locus_tag="A1178_RS02405"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="ERS515165_00473"
                     /product="replication initiator protein A"
                     /pseudo=""
                     /transl_table=11
                     /translation="MKRITASQYQTSERYYKLPKLLFESERYKNMKLEVKVVYSVLKDR
                     LELSLSKAWIDEDGAIYLIYSNSNLMALLGCSKSKLLSM"
     gene            complement(14908..15081)
                     /locus_tag="A1178_RS12605"
                     /old_locus_tag="ERS515165_00474"
     CDS             complement(14908..15081)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001168336.1"
                     /locus_tag="A1178_RS12605"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS515165_00474"
                     /product="hypothetical protein"
                     /protein_id="WP_001168349.1"
                     /transl_table=11
                     /translation="MQKEGQSSRQFVKSHLMTIMGVDIVKATQLVDEMEQVGLIRFDEF
                     GNVGILVLEGQS"
     gene            complement(15282..15650)
                     /gene="rplL"
                     /locus_tag="A1178_RS02410"
     CDS             complement(15282..15650)
                     /GO_component="GO:0005840 - ribosome [Evidence IEA]"
                     /GO_function="GO:0003735 - structural constituent of
                     ribosome [Evidence IEA]"
                     /GO_process="GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /gene="rplL"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018371186.1"
                     /locus_tag="A1178_RS02410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="50S ribosomal protein L7/L12"
                     /protein_id="WP_001196960.1"
                     /transl_table=11
                     /translation="MALNIENIIAEIKEASILELNDLVKAIEEEFGVTAAAPVAVAAAD
                     AADAGAAKDSFDVELTSAGDKKVGVIKVVREITGLGLKEAKELVDGAPALVKEGVATAE
                     AEEIKAKLEEAGASVTLK"
     gene            complement(15726..16226)
                     /gene="rplJ"
                     /locus_tag="A1178_RS02415"
                     /old_locus_tag="ERS515165_00476"
     CDS             complement(15726..16226)
                     /GO_component="GO:0015934 - large ribosomal subunit
                     [Evidence IEA]"
                     /GO_function="GO:0003735 - structural constituent of
                     ribosome [Evidence IEA]"
                     /GO_process="GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /gene="rplJ"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001287276.1"
                     /locus_tag="A1178_RS02415"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS515165_00476"
                     /product="50S ribosomal protein L10"
                     /protein_id="WP_001287279.1"
                     /transl_table=11
                     /translation="MSEAIIAKKAELVDVVAEKMKAAASIVVVDARGLTVEQDTVLRRE
                     LRGSEVEYKVIKNSILRRAAEKAGLEDLASVFVGPSAVAFSNEDVIAPAKILNNFSKNA
                     EALEIKGGAIEGAVASKEEILALATLPNREGLLSMLLSVLQAPVRNVALAVKAVAESKE
                     DAA"
     misc_feature    complement(16265..16400)
                     /db_xref="RFAM:RF00557"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:14.4:RF00557"
                     /inference="COORDINATES: profile:INFERNAL:1.1.5"
                     /note="ribosomal protein L10 leader region; Derived by
                     automated computational analysis using gene prediction
                     method: cmsearch."
     misc_feature    complement(16428..16444)
                     /note="TFBS match to NuR, Nickel-responsive regulator,
                     confidence: weak, score: 22.88"
                     /tool="antismash"
     gene            complement(16476..17735)
                     /locus_tag="A1178_RS02420"
                     /old_locus_tag="ERS515165_00478"
     CDS             complement(16476..17735)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Amidohydro_1"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397889.1"
                     /locus_tag="A1178_RS02420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS515165_00478"
                     /product="TRZ/ATZ family protein"
                     /protein_id="WP_001823042.1"
                     /sec_met_domain="Amidohydro_1 (E-value: 1.1e-72, bitscore:
                     239.1, seeds: 57, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKVFQHVNIVTCDQNFHVYLDGILAVKDSQIVYVGQDKPAFLEQA
                     EQIIDYQGAWIMPGLVNCHTHSAMTGLRGIRDDSNLHEWLNDYIWPAESEFTPDMTTNA
                     VKEALTEMLQSGTTTFNDMYNPNGVDIQQIYQVVKTSKMRCYFSPTLFSSETETTAETI
                     SRTRSIIDEILKYKNPNFKVMVAPHSPYSCSRDLLEASLEMAKELNIPLHVHVAETKEE
                     SGIILKRYGKRPLAFLEELGYLDHPSVFAHGVELNEREIERLASSQVAIAHNPISNLKL
                     ASGIAPIIQLQKAGVAVGIATDSVASNNNLDMFEEGRTAALLQKMKSGDASQFPIETAL
                     KVLTIEGAKALGMENQIGSLEVGKQADFLVIQPQGKIHLQPQENMLSHLVYAVKSSDVD
                     DVYIAGEQVVKQGQVLTVEL"
     misc_feature    18066..18081
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: weak,
                     score: 16.35"
                     /tool="antismash"
     gene            complement(18127..19875)
                     /locus_tag="A1178_RS02425"
                     /old_locus_tag="ERS515165_00479"
     CDS             complement(18127..19875)
                     /EC_number="7.-.-.-"
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="resistance (resist) ABC_efflux"
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000828810.1"
                     /locus_tag="A1178_RS02425"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS515165_00479"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_000828853.1"
                     /transl_table=11
                     /translation="MKRQTVNQTLKRLVVDLANHPFLLFLAFLGTIAQVGLSIYLPILI
                     GQVIDQVLVAGSSPVFWQIFLQMLLVVIGNTLVQWANPLLYNRLIFSYTRDLRERIIHK
                     LHRLPIAFVDRQGNGEMVSRVTTDIEQLAAGLTMIFNQFFIGVLMILVSILAMLQIHLL
                     MTLLVLLLTPLSMVISRFIAKRSYHLFQKQTETRGIQTQLIEESLSQQTIIQSFNAQTE
                     FIQRLREAHDNYSGYSQSAIFYSSTVNPSTRFVNALIYALLAGVGAYRIMMGSTLTVGR
                     LVTFLNYVQQYTKPFNDISSVLAELQSALACVERIYGVLDSPEVAETGKEVLTSDQVKG
                     AISFKHVSFGYHPEKILIKDLSIDIPAGSKIAIVGPTGAGKSTLINLLMRFYPISSGDI
                     LLDGQSIYDYTRASLRQQFGMVLQETWLTQGTIHDNIAFGNPEASREQVIAAAKAANAD
                     FFIQQFPQGYDTKLENAGESLSVGQAQLLTIARVFLAIPKILILDEATSSIDTRTEVLV
                     QDAFAKLMKGRTSFIIAHRLSTIQDADLILVLVDGDIVEYGNHQELMDRKGKYYQMQKA
                     AAFSSE"
     gene            complement(19877..21601)
                     /locus_tag="A1178_RS02430"
                     /old_locus_tag="ERS515165_00480"
     CDS             complement(19877..21601)
                     /EC_number="7.-.-.-"
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398743.1"
                     /locus_tag="A1178_RS02430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS515165_00480"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_061652836.1"
                     /transl_table=11
                     /translation="MKYLLSYFKPYIKESILAPLFKLLEAVFELLVPMVIAGIVDQSLP
                     QGDQGHLWMQIGLLLIFAVIGVLVALIAQFYSAKAAVGFAKELTNDLYRHILSLPKDSR
                     DRLTTSSLVTRLTSDTYQIQTGINQFLRLFLRAPIIVFGAIFMAYRISAELTFWFLVMV
                     AILTIVIVGLSRLVNPLYSSLRKKTDQLVQETRQQLQGMRVIRAFGQEKRELQIFQTLN
                     QVYARLQEKTGFWSSLLTPLTYLIVNGTLLVIIWQGYISIQGGVLSQGALIALINYLLQ
                     ILVELVKLAMLINSLNQSYISAKRIEEVFVEAPEDIHSELEQKQATRDKVLQVQELTFT
                     YPDAAQPSLRDISFDMTQGQILGIIGGTGSGKSSLIQLILGLYPVNKGRIDLYLDGLSP
                     FNLEQWRSWIAYVPQKVELFKGTIRSNLTLGLNQEVTDQELWQALEIAQAKDFVSDKEG
                     LLDALVEAGGRNFSGGQKQRLSIARAVLRQAPFLILDDATSALDTITESKLLKAIRENF
                     PNMSLILISQRTSTLQMADQILLLEKGELLAVGKHDDLMKSSQVYREINASQHGKED"
     gene            complement(21659..22597)
                     /gene="msrB"
                     /locus_tag="A1178_RS02435"
                     /old_locus_tag="ERS515165_00481"
     CDS             complement(21659..22597)
                     /EC_number="1.8.4.12"
                     /GO_function="GO:0033743 - peptide-methionine (R)-S-oxide
                     reductase activity [Evidence IEA]"
                     /GO_process="GO:0006979 - response to oxidative stress
                     [Evidence IEA]"
                     /GO_process="GO:0030091 - protein repair [Evidence IEA]"
                     /codon_start=1
                     /gene="msrB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001865281.1"
                     /locus_tag="A1178_RS02435"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS515165_00481"
                     /product="peptide-methionine (R)-S-oxide reductase MsrB"
                     /protein_id="WP_000818207.1"
                     /transl_table=11
                     /translation="MAEIYLAGGCFWGLEEYFSRISGVLETSVGYANGQVETTNYQLLK
                     ETDHAETVQVIYDEKEVSLREILLYYFRVIDPLSINQQGNDRGRQYRTGIYYQDEADLP
                     AIYTVVQEQERMLGRKIAVEVEQLRHYILAEDYHQDYLRKNPSGYCHIDVTDADKPLID
                     AANYEKPSQEVLKASLSEESYRVTQEAATEAPFTNAYDQTFEEGIYVDITTGEPLFFAK
                     DKFASGCGWPSFSRPISKELIHYYKDLSHGMERIEVRSRSGSAHLGHVFTDGPRELGGL
                     RYCINSASLRFVAKDEMEKAGYGYLLPYLNK"
ORIGIN
        1 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
       61 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
      121 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
      181 nnnnnnttaa ggaatctaac aactttgaga agttaatcga tttcttgtct tcatcataag
      241 cttttacagt tacttgggtt gtaagtatcc cctcttttcc ctcggctcga tagtcttgtc
      301 aatataaaac aaaaacaaga ttctgattat catctacaaa ggcattaact ccgttcttta
      361 tatcctgact ttcaaggaat tccataacgt tttgaagata ggattcataa aatagtgggt
      421 aattatgttt tttatggtaa tcatctaaaa atgttacctc aaactcacat ggataattgg
      481 gcatcaaaaa tatttgttca tccagctgtt tgatttctgc atcatgtaat tctgtttcta
      541 attcatcaca atctagtatt gattctttat ttaatgcttt tatctttttc ctctatttct
      601 tttaatttct ttgcgattgc ggcaatcaca ggaacggtta cactattacc aacttgttta
      661 tagagctgac tattaataga gacttttcta gcagcttcaa aagcctaatc aggaaagcca
      721 tgcaatcgaa aacactcttt aggagtgatt cgtcgtattc tcaaacggta aaattgtcca
      781 tctattaaaa caccagctac ttggtaaact tgtttatctt ctccttcata gctagccact
      841 actactccca tttgaccact agttgttaac gtattagcta taccttttcc aactctacca
      901 cgacgatact gagaacttgg tctttctaaa ttgattgaat ccccaatctc tgcttgagca
      961 tatccttttt tcgttgcttc ccgtactttt agaaattgga ttggttctgg aattagtatt
     1021 ttggggattt tatctcctcc ttgcatcgta gtcagtgttg gagataagcc ctcacttcca
     1081 tagacacgac ctgtctcctt aaagctagtc ggtaaatctc caacaacgac aatgccataa
     1141 cgatcctgag tatttaaagt aaacatcggc tcttgatttt ccttaaagcg tctcccattt
     1201 tgtctcttgt ctaatctatc tggtgtcata caaggaatcg caactttaaa tccttctcct
     1261 ttaccacgaa ctaaggttgg cgcaagacct tctgaataat agactttacc gctcattcca
     1321 cttcttgatg gattcaaatt tcctagtgct ttcaaagtct cagagttagt tgcttgacct
     1381 tctcgtctga aaggaaataa gagtctggta cctttctttc tagaatgtcc gataataaac
     1441 accctctctc tgtttttggg aacgccaaaa tccttactgt taagcacctg ccactcaaca
     1501 tcaaacccca actcatcaag tgtggtaagt attgtggtga acgtccgtcc cttatcgtga
     1561 ttgagtaggc ctttaacatt ttcaagaaaa agaaaacgtg gttggatttg tttggccgcc
     1621 cgagcaattt caaagaacaa agttcctcta gtatcttcaa atcccaatcg tcttcctgcg
     1681 attgaaaatg cttgacaagg gaatccccca cagatgacat cgactttccc tctaagtttt
     1741 ttaaattcgt catctgaaac atctcgtatg tcatgaaatt ctatttctcc ttccgtttga
     1801 aaaatggact tataagattt cctagcaaat ttatcaatct cacaaaatcc caagcactca
     1861 tgcccttgag cttccattcc catcctaaag cctcctatcc cagcaaataa atctaaaacc
     1921 caaatcattc atacctctct caactagatg taacttacaa aacccctgac ctcatgagcc
     1981 actttcttcc tcctcatgag gtcagtttta ctttctgctg ttccagtatc gtttttcctc
     2041 gctagatttc ctcaaaaggg cagactcctc ccttggttcg tcacacgatt ttttcatctc
     2101 gactgttctt taatgcatca ttaacgacgc ttttcttcta ggtggttcat aaggaacagg
     2161 aagattcagg ttgacttttc taatcctaga ataaagtgct gaaaacaatt cggaataggc
     2221 atagagacta gacaatttga ggagctgctt gcgtcctgtt cgaacacatt ttcctaccac
     2281 gtgaagaaaa agatggcgga agcgtttgat tgttaaagtt tggaagtcac ctccagctag
     2341 atgtttgaga aaaagataga gattgtaggc gatacagctc atcatcatac gaacttcgtt
     2401 tttgattaag gttgaactat ccgttttatc gccaaaaaat ccctccttca tctccttgat
     2461 gaaattctcg gcttgaccac gtccacgata aagctgaaac tggtcttggc ttgttccact
     2521 cgtcatattt gtaacgagag aaataacatc gtagaacaag tttccttctt ttcgttcaga
     2581 gaactggcag acacgacgct tgtgcgacca agatcctgct tgatagagag tttctgagta
     2641 ggcggagtgg ggcaagatgg ttaagtcctc atcctgtggg caagggaggg aaaggtctcc
     2701 aagacggctc agaacagtat ttttcttgag ttttatgagg tagtattgcc ctgttttttc
     2761 aattaaatcg tataattttg gggtcgcaaa gccactatcc attcgaaaga gaagttgatt
     2821 aaaccgttct aaaacaggtg tgataaagct gtctgcctct tcagaacaat aacgattacc
     2881 aggacgaagc tgggcattga aacaataacc tgtcttcccc tcgaaagcat aaagaggatg
     2941 atagccatga gcacgatagt gggcgttata agcaacacct tcttgcttgc cataagttgt
     3001 gaaatgggta gaatcgatat ctacaatgag ttggtttagc tggtgaaact gtaaaaagaa
     3061 ttcgaccaat tcaaggttga ggcatcgcaa actatggact gtttcctcgt cagttctgga
     3121 aagaaaacgg gataaggttg gctgtgaagc aagctgccct ccttccaata attttggaaa
     3181 gtaggcatca gctgacaatt ctttacaagc atagtccgtt ccataacctg ttaacagttg
     3241 aaagaggaac tggacaagga tatctgaatc cgaataacga cagtagcggc gttggtcatt
     3301 cgttactaaa tacttagaaa tccgctcttt tagtttcagc tgggaaaaaa gttcctgaaa
     3361 aaagataaga ccaccatact gggttaaatg acctccatcg aaagatagtt ggtaaaaaga
     3421 cttgttttgg aagtgatgat ttggtaaact gttcatgtga gtttcctttc tttttgtgtt
     3481 tttttctaca cttataccat aaaggggaaa ctcttttttg tctagtaaaa aacacccatt
     3541 gggtgaaaaa agaaaccatc caggatctaa gctaaggcaa ggattctgga tggtttttag
     3601 atttggggtg aataattggg gtttaaaatt gtctaaattc gacagaagga agtagcaagc
     3661 attgtcgcta aaaaaatgca tcaggttatc ctgtgcattt ttttgatatc aaaataatca
     3721 atctccttta tgagctaatt cttctctaca agctctttgg agcagaacaa ctgtaagtat
     3781 aaaaaccaca cataaaatca agatacttct ctcagcccca aaaacaccac tagtatataa
     3841 atcttgaccc gttaaatttg tactgaataa actaaatgaa acttttatcc cactcactaa
     3901 tactattata tcaacccact acagttgaca aaaagacaaa ccagcctaat gactagcttg
     3961 tcttcaatca agagaggatt ctgttccccc catataagca ctaacattcc aacgtgcaca
     4021 tattggaacg acatccataa ctccagagaa tctctaaagt ttacaattta aatgaattaa
     4081 caattttccc aactaaaagc actccagtta ccgcaacggt ttgtactgaa tgtactaaat
     4141 cgcattccat caacttcatc tgtttcgtca acttgaacag atactaattg aagatttaat
     4201 acttctgctg ccatagctag ctcctcctat ttaaattttt gggattaagt actttatcca
     4261 ccctcatata ctctctccac cagtaaaatg caagcaatga tacaaaatag atttaactat
     4321 tttatatagc gaaaacttac aaatttttaa gaaataattt ttgcattctt aaagataaaa
     4381 taggaacttt tagtaataaa tattaaaata aataaaataa tagatactat aaaatttgga
     4441 agtattaacc ccaaaagatt catatcatct attaaaatat cctctaaaga gtagtatatt
     4501 aaagccataa ttttaatgtt aagtaaaaat gcaattaatg aagtaacaaa tgtcaaaaat
     4561 atagcctcac caactttaat cttaaccatc tggtaattag aagttcctaa aatttcaaat
     4621 tgctgaatct caatcctttc ttgatgcgat gacaaaaatg caattgaaat aatatttgca
     4681 agtactatca aaattggtgc tcctacatag acaataaatg ctacttttag ctctaaatca
     4741 ctgtcatctt gaaattgaga tagtatattc tgagaaatca tttgaaaact agaaattagt
     4801 aatatagctc ctgtaattgc agcactgata gattttatat aagacttaca atatagtaaa
     4861 ttccacttcg aaacaatgaa cataaaatta tttctaaata taattataga aagtagtttg
     4921 ataaaacatg actgtataaa aggagataat tgataaataa tcacaatatc taagattaca
     4981 atattgaata ttatctgggc cttcgctaaa attgtgctat cttggaaaat ttgttgcaaa
     5041 gaaagcaacc agataacact aaaaccagcc aatagcagta ttctttttac tattgaaaga
     5101 acatgcctta ttttagaact cttcctattt ctaatcttct tgaacgtata aaagcaacca
     5161 cttagaaagg ctaaaaatga aatcaacact actgtaatga tacatccaac agcactcgtt
     5221 tgaaattgga tatcaggtaa tatattttcc ccgaaaaagt attgtaaaaa ataataataa
     5281 tttgacgtaa caaatataga gcatagatat gcaataaaac taataatcga ggaaatgata
     5341 aaaatctgtc cccccacaag aaatgatagt tgaaggcgac ttgctcccaa cacctccaga
     5401 agttcgtaat catctctaaa aatttcaacc aacatattta ttatgttaga gagcacaaag
     5461 aataatgtta ctcctccgaa tactatcgga aacataaaaa ttggtttagg atctggaagt
     5521 ccgacaaata cttgcgaatt attctcaaca ttaattaccc cattaacagc caatcccata
     5581 actaaactcg aaacaaaaat tactggtgaa acgcctaacc attgtttctt attatgtaaa
     5641 aattgatagt aaactaatct gagcatctct attcctccgt agttgattgt acctctaaga
     5701 ttttatacaa ctcttccccg ctaggtctat gaagttcttt gaaaattttt ccatctttca
     5761 atattaatgc acgatcagtt ttcgaggcca attctatatc gtgcgttacc ataattacac
     5821 acttacccgc ccctactaac tctctcaata attcaaaaat tacttcacga gaaacgctgt
     5881 ctaaagcccc agttggctca tcagcaaata ttatatcact atcagcaata accgctctag
     5941 ctatagcaac cttctgttgt tctccaccag acagagttcc aacaaaatcg tttaagccag
     6001 cattaaactt cattcttttg agtaagtttt ctacattttt aatagttaat tttttttgtg
     6061 ataatcgcaa aggaagtgct atattttcta ttaccggcag ggaaggtatt aaattgtatg
     6121 cttgaaatat aaaagatact tcgttacgtc ttatacttga caattttgca tttctgattt
     6181 tataggggtt gattccattt aaaattactt ccccacttgt tggttcaagc aaactagaaa
     6241 tacattttaa taaagttgac tttccagaac cactaattcc tagaatactt ataaattctc
     6301 ctctcgaagc agaaagagaa acatttttca gcacttgcaa cgttttatta tttcctagta
     6361 aaaattgatg atacagccct ttcactttta atatataatc tttatccata ttcttgcctc
     6421 caatcactta attttgaaaa gtgttccatt ttccaattta tatatatcag tgtatctctt
     6481 gtcatttaag tcataatgat gtgaaacttc aataaatgaa atacctaaat tgaacagaat
     6541 atcatgtatg gaatttgaat tatcattatc taaattagct gatatttcgt caaataagta
     6601 cactttatta tttctaatca gagctctagc taaagctatt ttttgttttt gacctccaga
     6661 caaattacta ccattttcac cacattgata atttagtata tctatctttt ctaattcttc
     6721 atatagattt acctttttta acacctcaat tatctgatca tctgaaaaat attcattttg
     6781 aaataaagtt acgttctcac gaatagtagt gtcaaaaata tatggtgtct gatcaactgt
     6841 tggtattgaa tctgaactct ttttcccatg tgataacaaa tttacataac ctttttgtgg
     6901 ctttaaagaa ccattaatta aatttaaaat cgttgttttc ccactaccag aagttcctgt
     6961 taataatacc ctaaatggtg acttaaatga gaagtcaata cttaatttat tttctggtgt
     7021 aatagaatat acaacatctt tcatgtgtat ctcatctatt gatgaagtat acagtccgtt
     7081 attatcatgt tcagcgtcta taaaattctt ctctccactt aagtatttta aaaacggttt
     7141 ccttaaatct ttggttgtat ttatcttatt taatgaatag gcaattgatt gtatcggccc
     7201 taaaacttta tcgtttgcta agaaaatacc tatcagttca ctaaaagaaa ggcttttatg
     7261 ataaattaca aaataacatc ctacaaccaa gggaactaga aagcaaaaac ctgaaattag
     7321 tactgcaacc aattttgaaa gaacctctga tcgtttcaaa ttaaaagtag aatcttctag
     7381 tttatccaac tttttatccg acaaactaat tatttcttta gtaacagaat aagattttaa
     7441 tgtcttaaaa ccattaaaaa tttcttttat tatgtgagta tactctgcat tgctgttaga
     7501 gtactcatta gctgaattag acaacatctt cttcataaag acaggtacta taatcggcaa
     7561 tgctgataat acaataaata ttattgaaac taggaagttt aaataaagca taaaacttag
     7621 agagacgatg aacaacaata ttgaagaaat tatttcaaaa atttgtctaa aatagttttc
     7681 ttcgattaat ctcaaatcat ttgacaaaac tgaaataata gatgagtaat ctttaaccat
     7741 ttcagaagaa agatactgtt ctctaaaata tccttgttta atttttacat ttatatcttt
     7801 agttattgat gcttccgtta cttctaaata gtaatttgat atatagattg ctgaccaacc
     7861 cagaatactt atagcaccaa atcttagaac gtcagaaaat gaggaagtct gatttaaact
     7921 acctgcatat acaataattc ctgagagcaa gacaccatta aacgaagata gaaatattaa
     7981 aatccccatt aatataagtt tagtcttttt tataaatttt aaataattca taagttattc
     8041 cttcccactt cttcaaagaa ataatttaaa gtatcaatca ttaagagaac atctgatgga
     8101 gtaaaacctc catgaccagc tgctttgttt aaatacaaca aacttttaac tccaatagaa
     8161 tttaatttct ttgaccactc tatcacttcg ttattattaa tatatgggtc tttctcaccc
     8221 aaaatattaa ctataacagt atttgagtct cgtgcctttt caatattttg cataggcgaa
     8281 tatgacttta tataagcctt tacttcaggg tctctaatat ctccccactc tgctatttcg
     8341 gtcttagaaa gaggatcatt tggattctga agtgtatcat aaggatttat aaatggcgaa
     8401 aataagagaa tgctttgcaa taaatttttt tcctcgttca acaccgcacc agcaattatt
     8461 ccacctgcac tagaagttat taaacctaat cgcttactgt caattacatc attttccctt
     8521 aaataattta ctccctcaat aaaatctctg atagaattcc atttgtttaa cgcctttcct
     8581 gagcgatacc attcaccacc caaatagcct ccacctctta catgaactat agcataaata
     8641 aaacctgcat ctattataga taacataatt tcatctaaat cagaattatc attcttacca
     8701 taagccccat agacacttag aatacatttt tttcttcttg ggagctcatc cgtatcttca
     8761 cttttccaaa ataaagaaat cggtatgctt acatcataac tgtctttttt agtccaaatc
     8821 accttagaaa aatatttagt attattcgat tttatgatgg gtctttcaaa ttcagttttt
     8881 aatgtatttt ctattaaatc aaaactaagt attttttcgt aaaaagttct cctctctaaa
     8941 aacagaagaa cacgatcaga aaatgaattt tcataaagtg ttgtcttttc atcaaatgtt
     9001 atcttattaa cactcaactc cctcaaacta ttatttttaa atgtagcaag ataaaagacg
     9061 gaattcgctg cgtttgaaca gtctaaaagg atataacgtc ctatacagtg aactcttcta
     9121 gccctatctt gatatggtat agtaatagaa actctgtctc ccgaagaagt ttcccttaga
     9181 attagttgat ctttcttttc ttcagttgaa gagagcccaa gaaagtactg tgctttttct
     9241 gtactaaata gagcgatatc tctaggtgtt ggggctaccg tttctgtgta agagtgtcta
     9301 acaaaacccg tccggtcgaa actgtataga aaaatcctgc ctttctgaaa gtctactgac
     9361 tttacaaaac aattattgct atcaatgtgg actattttta atcgaaaaga gcattcgttt
     9421 tcttcaaaca gttcctcttc tgtaaagcta tcaaaagatt tatagaataa cttacttggc
     9481 ctcccgtact ctttggagcg agtatacata acaccgaatt tacccaaata gaacgaactt
     9541 tctactgaaa tatcttcaat gataaataac tcttccatag tatatttttt tattccaatt
     9601 aaattagtgc tacgcagtga ggatacaacc aaaactatat aactctcatc agatgaaatc
     9661 ctaacatcct gtaagatact atcatctggc aaagtatatt tttccacatc aaagacaatt
     9721 ttaagtgaat ttgaattgtc taaactggaa gaactaacct taggaatcca gtcattatct
     9781 tcgacatacc attcctttat tacaccagta ttgggtatac tccaattatc aaattggtac
     9841 caatatcgcc ctctcctaaa tatcaaagaa ttccattttt ttaattcctg aaatgatgaa
     9901 gagatagacc tcttatagtg tgttttttcc tgtattgtat ttaaaaatat ttcattactc
     9961 tgattcacaa gtatgacccc ttaataatgg tatctaaata ttatatttga ggaagaatcg
    10021 tcaatttatt atccattatt gataccaatc caattgcaac acccgcaaat cccgaagcaa
    10081 tatctgttgt tatctttaaa ccattatctc ccgcaataac aaatccttct tcaattacac
    10141 acaaatatct ataaagttgt tcaattaatt tcttttgtcc tgaaaagtta tcatcgatat
    10201 cactatatat attattagca acttcaagac cacaaaatcc gttaaataaa cctggtaata
    10261 cacaaaaaac tacatcagtt gccctctcta aagaagttaa atattttaag tatttgcttg
    10321 acaagatttc tttatttcta ttaataagta aaagcaggcc agcacttcca gttgctagat
    10381 atggtagtaa tctatgacct tggctgtact gcaatgaatt attactatct actttataag
    10441 caactaattc tttatctaca gccaattcta gaccattttt atagatactt tcaccagtta
    10501 atttataagc ttcaccgaag agccaagcta cccctgcgtg accatatagt aatccaccaa
    10561 aattctcata aggatcgtta ctctgaacat cactagcgcc aactttacaa aaagtttctg
    10621 gattttctat ataatttaaa gtatattctc taagcctaat tagtatttct tctcctagtt
    10681 tattatcaat tcccccttta ctaagaaaat acagtccaac cagtaaaatt ccagcctgcc
    10741 cactatataa atttttattt tgtgaattct caaatatctc tataaaatga gttgtaaaaa
    10801 gttcaactgc ccgatctatc tccccaaatt cataaatgag ccagattgta ccaattttac
    10861 catcaaaaag accagaaagg gacgatttct taaaattatt tactgcctca ttaataacct
    10921 gtgttcgaat ctcataatag tcatcaaact tgaaattttt tactttctta gctagttgtt
    10981 gataactcca aaggatagct aaatctgaaa acgcaattcc ttgattaaaa ttcagaccat
    11041 aataatgaac tgggaagaat cttgattgaa attctttacg ccactgtcca taagttagcg
    11101 taaaccctct caataatttt ataataaaat cttgtatatc ttgctcactc tcgatagttc
    11161 taatctcatg catgggtttt aaaacttttt tcctggaaat attctcaatc tgtggacatt
    11221 tagaatctag atatgacaat aaactttcta cataatctat atgttctctt gtataaccca
    11281 aagactcaaa tagttttttt ccttctatcc tggtttgact tacatagttg tatgtcaaat
    11341 ccgatgtagt tactagtggc atgtataaat aatgagctat ttgtctaata ccataccaat
    11401 ctatctcact gggaagtgtt tctcgccatg ctctaaaacc aggggctgca actttatgta
    11461 caactttttc atcatttgaa aagacagcct gttcccagtc tattatacta atctcatctt
    11521 catccttaac caagatattt cctaaatgta aatcttgatg atatacattt tcagaatgaa
    11581 acttattcgt taaatcgatg agtttttcta ctatctttga aactctcaat agataatctt
    11641 tggtcttatc aacaacttca tataaaggaa aattattggt aacccatcta tttagtggaa
    11701 cgcccttcat atgttcaatt cctaagaagg tgtgctccca gatcttaccg tgccagtata
    11761 ttttaggcgt ctcactccat tcatttagaa tttttagtgc tttgcactcc gaagctaatc
    11821 tctctgaaga ataagtacca tcaaatccta gacctgtata cggtctagcc tcttttaaaa
    11881 ttattttttt cccatcttct tttagcctag cattatatat cccaccactg tttgaaaatc
    11941 taattgcatt atctataata aagggaaagt ctccctgttt tttatctttc ttgtcaagcc
    12001 atttattcaa aaagtcaggg ggcactatac cttttggaat tttaaatact ggtaaacgtt
    12061 catctttaac aacttcatcg ccaacaatta attcatcaat agcaaccttc ttttcatcat
    12121 cccttgacgg cctaaacaca ccatacctca gatatattgg tgcttcatcc caacgtttat
    12181 cgcttaaaat atatggccca ttatattgct ttaaagcact ttctaacctt tgcaaaaccg
    12241 actctaattc attttgattt ggataacatg taataaattt accagaaaat cctcgactaa
    12301 ccaatttccc gtttcgcatg ataaatttgt cttctgtact aagatgttta aatggaattc
    12361 gcatttcatg gcaaattttt gctacatctt gtaacaattc atgtgaactg ttatactctg
    12421 aactaatgtg tattttccac ccttgtcttt caacaaattt tccaataggg tattgataaa
    12481 cccactcatc attattcatt acttcgtgcc aattaaaagg cagacttact tggtacttta
    12541 tgctagtatc tgtactataa tcattattag tgaaaaagaa aggatgctcc aaattgaaat
    12601 tataatccat aacaaaatct ccaagaaatt ttatcaaact taatatatct atagctagac
    12661 agacttattt aaataaaaag ggagaatcct ttggattctc cccatataag cactaacatt
    12721 ccaacgtgca catattggaa cgacatccat aactccagag aatctctaaa gtttacaatt
    12781 taaatgaatt aacaattttc ccaactaaaa gcactccagt taccgcaacg atttgtactg
    12841 aatgtactaa atcgcattcc atcaacttca tctgtttcgt caacttgaac agatactaat
    12901 tgaagattta atacttcttc tgccatagct agctcctcct atttaaattt ttgggattaa
    12961 gtactttatc caccctcatt atactctctc caccagtaaa atgcaagcaa ttatacaatg
    13021 ttgtcacata gaaaataatg tttccgtaac ttttcaaagt aacttccatc tctctcccaa
    13081 aactggaagt tagttttaga agttacctaa aaatcaggtc acctatttta aaaaagcagc
    13141 aaactataaa ctagtaggtt ccacaccaaa tgtagcccca tactgcccca taagtccaat
    13201 ttgtagcgta caagccctaa aaacatcccc agcgatacat acaaacacca agctataatg
    13261 gttcctggat gatgtgctaa ggcaaataaa acacttgtca acgcaactcg aatatctaat
    13321 tttctaacca agttccataa aatttctcta tacagaaatt cttcaaccat actcgcattg
    13381 attaaaaaca ataaaaatga aaaccaagga acttgatgtt gaagcccaat taagtttgct
    13441 tgattcgtgc tttcttgcgc atggattaga ctaaaacata gacttataat cagtagacta
    13501 gctagtccaa taccaagcca tttcatccta gatttcatat ttaccttatg agcttgtttg
    13561 cgttggccat acatccataa aaaagaaatg agtgacgaac catagagaat ctgtagtata
    13621 gttaactcac cgatacaaag aaatttcaat aagtatagag ataccaatag gacatttact
    13681 tgttggaata tataaactgg aattattctt ttcatagtta cctccgaaat aaatcttcat
    13741 aatctaaatc taatacctgc acaatccttt ctacccatga actttgaggc attcgttgtt
    13801 ccatcttcta gtggcgaatc ttttgataca aacgattcaa ttcacttgga tagtgaaact
    13861 ctcccgcaaa catttttctg gttaactcaa tacagctgat atttctttca gccaaaataa
    13921 tggacaagtt ctcccaaaat cgttcagcca tattgcttct cctttagtta gataaataat
    13981 gtgtttgcgc catgtaaatc aattgtttcg tatctcttgg caatagagct ctagcctctt
    14041 ccaaattcag acttggataa nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    14101 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    14161 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    14221 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    14281 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    14341 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnntt aaggaatcta ataaatttgc
    14401 gaagttaatc ggtttcttgt cttcatcata agcttttaca gttacttggg ttgtaagtat
    14461 tccctctttt ccctcggctc gatagccttg tccatataaa acaaaaacga gattttgatg
    14521 atcatctaca aaggcatcaa ccccattctt tatgtcttga ctttcaagga attccataac
    14581 gttttgaaga taggattcgt aaaatagtgg gtaattatgt tttttatggt aatcatctaa
    14641 aaatgtcacc tcaaactcac atggagagta attttgactt tgaacagcct aaaagtgcca
    14701 tcaaatttga attggaataa atcaaataaa tagccccatc ctcatcaatc caagctttgc
    14761 tcaaagacaa ctccaaccga tcttttaaaa ctgagtaaac caccttaacc tccagtttca
    14821 tattcttata ccgttcactc tcaaataaaa gtttggggag cttataataa cgctctgatg
    14881 tctgatattg actagcggta atacgcttca tgattgtccc tccaagacta aaattccaac
    14941 atttccaaat tcatcaaatc ggattaaacc tacttgttcc atttcatcaa ctaactgagt
    15001 tgcttttaca atatcaactc ccatgatagt catgagatga ctcttcacga attgacgtga
    15061 tgactgtcct tccttttgca taattacctc cgaaacacaa aaaaaggggt agacaatcta
    15121 gtgtctacct ccgaaaattt attaaaaaga aaaaccctgc caaagaattt ttggtagggt
    15181 ttttggtagg aaactaaata aatttatcag tttctaaaat gtgttcacga ttctaaaagg
    15241 ctgatactat agtattccga attctaattg gtatatgcct cttatttaag agtaactgaa
    15301 gctccagctt cttccaattt agctttgatt tcttcagctt ctgcagttgc aacgccttct
    15361 ttaacaagtg ctggtgcacc gtcaacaagt tctttagctt ctttaagacc aagaccagta
    15421 atttcacgta caactttgat aacgccaact tttttgtcgc ctgcagatgt caattcaacg
    15481 tcgaatgaat ctttagcagc accagcatca gctgcatcag ctgcagcaac agctacagga
    15541 gcagctgcag ttacaccaaa ttcttcttcg atagctttta caaggtcgtt caattcaagg
    15601 attgaagctt ctttaatttc agcaataatg ttttcaatgt tcaatgccat tgttatttcc
    15661 tccaaataag ttttaaattt tataatagtt tttttcgtag ctaggctacg ctgtgtagct
    15721 taagattaag ccgcgtcttc tttgctttct gcaaccgctt tgactgcaag agcaacgttg
    15781 cgcactggcg cttgaagtac agaaaggagc atagaaagaa gtccttcgcg gtttggaaga
    15841 gttgcaagtg caagaatctc ttctttagat gcgacagcgc cttcgattgc accaccttta
    15901 atttcaagtg cttcagcgtt tttagaaaag ttgttcaaga ttttcgctgg tgcgataaca
    15961 tcttcattag aaaatgctac tgcagatggt ccaacaaata cagatgcaag atcttcaaga
    16021 ccagcttttt cagctgcacg acgcaagatt gagtttttaa taactttata ctcaacttcg
    16081 cttccacgaa gctcacgacg aagaactgta tcttgctcaa ctgtcaaacc acgagcgtct
    16141 acaacgacga tagatgcagc agctttcatt ttttcagcta ctacgtcaac tagttccgct
    16201 tttttagcaa taattgcttc actcattagt gtgttcacct ccgtaattat tttgcttggg
    16261 gaatttttca aaaagaaaaa cgcgcccaaa cctagacacg aaagtacaat acgcttcttt
    16321 ttacatgata cgtcttgtcc tcggtaggat atttatgagt cgagctcccc tactgtctta
    16381 ggcagttttt ttaaaccgta tataagtata gcatagtcaa aaaaagaatg caagattttt
    16441 gcaaactttt tttaaaattt ttcgtgattt ttcttttaaa gttctactgt caggacttga
    16501 ccttgcttaa caacctgttc tccggcgata taaacatcat ctacatcact agatttaact
    16561 gcataaacca ggtgagacag catattttcc tgaggttgga gatgaatttt cccttgtggt
    16621 tgaatgacca gaaaatctgc ttgcttgccg acttccagac ttcctatctg attttccatt
    16681 ccaagggcct tagccccttc gattgtcagt accttgagag ctgtttcgat tggaaactgg
    16741 ctggcatccc cacttttcat cttctgaaga agagctgcag tccttccttc ctcaaacata
    16801 tctagattgt tattggaagc aaccgagtca gtcgcaattc cgactgctac tcccgctttt
    16861 tggagctgga taattggagc aattcctgat gccagtttga ggttactgat aggattgtgg
    16921 gcgatagcca cttgagaaga tgccaagcgt tcaatttctc tctcgtttaa ttcgaccccg
    16981 tgagcaaata cggacggatg atctaaataa cccagttctt caagaaaagc aagggggcgt
    17041 ttgccgtatc gtttgaggat aattcctgac tcctccttgg tctccgccac atggacatgg
    17101 agcggaatat ttagctcttt tgccatttcc aaactcgctt ccagcaagtc tctactgcag
    17161 ctatacggag aatgaggtgc taccataacc ttgaaatttg gatttttata ttttaagatt
    17221 tcgtctatga tggatcgagt tctgcttata gtctcagcag ttgtttctgt ctctgaagaa
    17281 aagagagtcg gagaaaaata acaacgcatc ttggaagttt tcaccacctg ataaatttgc
    17341 tggatatcca caccattggg attatacata tcgttaaagg ttgttgttcc tgactggagc
    17401 atctctgtca gggcttcttt gaccgcattg gtagtcatgt cgggagtaaa ctcagattct
    17461 gctggccaga tatagtcatt gagccattca tggagattgc tgtcatctcg gatccctctc
    17521 agacctgtca ttgcagaatg ggtgtgacaa ttgaccaaac caggcataat ccaagctccc
    17581 tgatagtcta taatctgctc agcttgttct aaaaatgctg gcttatcttg accaacatag
    17641 acgatttgag aatccttgac tgctaagatt ccatcaagat aaacatggaa attttgatca
    17701 caagtcacga tatttacatg ctgaaagact ttcattatag actccttttt taaaagacaa
    17761 gttgtactct cttcaaacca cttcagattc actttgccgt aggtgtggtt actgacttcg
    17821 tcagttctat ctgcaacctc aaaacagtgt tttgagctga cttcgtcagt tctatctgca
    17881 acctcaaaac agtgttttga gctgacttcg tcagttctat ctgcaacctc aaaacagtgt
    17941 tttgagctga cttcgtcagt cttatctaca acctcaaagc tgtgctttga gcaacctacg
    18001 gctagcttcc tagtttgctc tttgattttc attgagtatt acagtgaaca atttttctag
    18061 ctattgtaac aaaaaagtca ctcgaaggca acttttttcg tccataaact ttcaaaagag
    18121 aatggcttat tcagaactaa aagccgcagc tttttgcatt tggtaatact taccctttct
    18181 atccatgagt tcttgatggt taccatattc aacaatatca ccatctacta agacaagaat
    18241 taaatccgca tcctgaatgg ttgacaaacg gtgagcaatg atgaagcttg tgcggccctt
    18301 catgagtttt gcaaaggcat cctgtaccag cacttctgtc cgtgtatcaa tggaagaagt
    18361 tgcctcgtct aagataagaa tctttggaat agccagaaag actcgggcta tggtcaagag
    18421 ctgagcttgg ccgacagaga gagattctcc agcattttcc aacttggtat cgtatccctg
    18481 tggaaactgt tggatgaaaa agtctgcatt agctgctttg gcagcagcaa ttacttgctc
    18541 tcgactggct tcaggattgc caaaggcaat attatcatga atggtccctt gtgtgagcca
    18601 ggtttcttga agcaccatac caaactgctg tctcaatgat gctcgtgtat aatcataaat
    18661 ggattgccca tccagcaaga tatctcccga gctaatggga taaaaacgca taaggagatt
    18721 gataagagtt gattttccag cacctgtcgg accaacgatg gctatcttac taccagctgg
    18781 aatatcgata gacaagtcct taatcaaaat tttttcagga tggtagccaa aagagacatg
    18841 tttaaaggaa atagctccct taacttggtc actggtcaag acttccttac ctgtttcagc
    18901 cacttcaggg ctatctaaga ctccatagat acgctctacg caagccagag cactttgcaa
    18961 ctcagctagc actgaagaaa tatcattaaa gggcttggtg tattgctgaa catagttcaa
    19021 aaaagtcact aaacgaccga cagtcaaggt tgaacccatc atgatacgat aagctcctac
    19081 tccagctaaa agggcataaa tgagtgcatt tacaaagcga gtcgaaggat tgaccgttga
    19141 agaataaaag atggctgact gagaatagcc tgagtagttg tcatgagcct cacgcaatct
    19201 ttggataaat tctgtttgag cattgaagga ctggattata gtctgctggc taagcgattc
    19261 ttcaatcaac tgagtctgaa ttcccctcgt ctctgtttgc ttctggaaga gatgatagga
    19321 tctcttggca ataaagcgtg aaatcaccat ggacagtggc gtcaacagca agactaagag
    19381 agtcatgagg agatgaattt ggagcatggc tagaatacta accaaaatca tcaaaacacc
    19441 aatgaaaaat tggttaaaaa tcatggtcaa gccagctgcc aactgttcga tatccgtggt
    19501 tacacgactg accatctctc cattgccttg cctatctaca aaggcaatcg gtaaacgatg
    19561 gagtttatgg atgattcgct ctcgtaaatc tctggtataa gagaagatta gacgattata
    19621 gaggagagga ttggcccatt gtaccagagt atttcctatt accaccaaga gcatctggag
    19681 aaaaatctgc caaaaaactg gtgatgaacc agccactagg acttggtcaa tgacctgccc
    19741 aatcagaata ggtaggtaaa ttgataagcc aacttgggca atagttccta gaaaggctag
    19801 gaaaaggagg aagggatggt ttgctaaatc tacgactaaa cgtttgagcg tctggtttac
    19861 agtttgtcgt ttcattctag tcctcctttc catgttggga tgcattgatt tcacgataga
    19921 cttgactgga tttcatcaag tcatcgtgct tgccaacagc tagcaactca cctttttcca
    19981 agaggagaat ctggtccgcc atctgtaaag tcgaggttcg ttgagagatc aaaattaagc
    20041 tcatgtttgg aaaattttct ctaatagctt tcaagagctt ggactcggta atggtatcca
    20101 gtgccgaggt cgcatcatct aggatgagaa acggagcctg gcgcaagact gctcgtgcga
    20161 tagacagcct ttgtttttgt ccacctgaga aatttcgacc tcctgcttca actagagcat
    20221 ccaagagtcc ttccttatca ctgacaaaat ccttagcttg agcaatttcc aaggcttgcc
    20281 agagttcttg atcagtcact tcttgattta aacctaaagt caagttggaa cgaatagttc
    20341 ccttaaagag ttcgaccttt tggggaacat aagcaatcca agatctccat tgctccaaat
    20401 taaaaggact caatccatct agataaaggt caattcttcc cttgtttact ggataaagtc
    20461 caagtatgag ttgaatcaag cttgatttac cagaaccagt tcccccgatg atacctagaa
    20521 tttgtccttg agtcatatca aaggaaatgt ctctcagaga aggctgggct gcatcaggat
    20581 aggtaaaggt caattcttgg acttgtaaaa ccttatctct ggtagcttgc ttttgttcta
    20641 actctgaatg gatatcctct ggagcctcaa caaagacttc ctcgattcgc ttggctgaga
    20701 tataggactg gttgagggaa ttgatcaaca tggctagctt gaccaattcc accaaaatct
    20761 gtaagaggta attgataaga gcaatgagag caccttgact gagcactcct ccttgaattg
    20821 aaatatagcc ttgccagata ataacgagaa gagttccatt gacaatcaga taggtcagag
    20881 gtgttaataa actagaccag aaacctgtct tttcttgtaa tctagcataa acttggttaa
    20941 gggtttgaaa aatctgtaac tctcgttttt cttgaccaaa agcacgaata acccgcatcc
    21001 cttgcaattg ctggcgcgtt tcctgaacca gttggtccgt tttctttctg agactactgt
    21061 agagaggatt gaccaatcga gataacccta caattacaat ggtcaaaatg gcaaccatga
    21121 ctaagaacca gaaagtcaac tcagctgaga ttcgataagc cataaaaatg gcaccaaaaa
    21181 cgataatggg cgctcgcaaa aagagacgca ggaattgatt gataccagtc tgaatctggt
    21241 aggtatccga agtcaagcga gtgaccaaac tagaagttgt cagacggtct ctgctgtcct
    21301 tgggcaagga aagaatatga cgataaagat cgtttgtcaa ttccttagca aagcctactg
    21361 ctgcctttgc tgagtaaaat tgagctatca aggccactaa aacgccaatt actgcaaaga
    21421 taaggagcag gccaatctgc atccagagat gaccttgatc tccctgaggt aaagattggt
    21481 caacaatccc agcaatcacc atgggaacca agagctcaaa aacagcttct aacagcttga
    21541 acaagggggc taaaattgat tccttgatgt agggtttgaa gtaagataat aggtatttca
    21601 taaatccctt ctattcatat tctagaaatg aagaaagtgg gaagccccac tctctgtttt
    21661 atttgtttaa gtaaggcaat agatagccat atcctgcttt ttccatctca tccttggcca
    21721 caaagcgtaa agaagcagaa ttgatacagt aacggaggcc gcctaactcc cgcggtccat
    21781 ctgtgaaaac atgacccaag tgagcactgc ctgaacgaga acgaacttca attcgctcca
    21841 ttccatggct cagatccttg taataatgaa tcaactcttt ggaaatcgga cggctaaaac
    21901 ttggccaacc acaacctgaa gcaaacttat ccttggcaaa aaagagtggc tcacctgtcg
    21961 taatatctac ataaatcccc tcttcaaagg tttggtcata ggcattggta aatggagcct
    22021 ctgtagcagc ttcttgtgtg acacgataag actcttcaga tagactggcc ttcaacacct
    22081 cttgactagg cttttcatag tttgctgcat caatcaatgg cttatcagca tcggtcacat
    22141 cgatatgaca gtaacctgaa ggattcttcc tgagatagtc ttggtggtag tcttcagcca
    22201 gaatgtagtg gcgtaattgc tccacttcta ctgcaatctt tcgacccagc atgcgttcct
    22261 gctcctgcac cactgtgtag atagctggca aatctgcttc atcctgataa taaatcccag
    22321 ttcgatattg gcgaccacgg tcattccctt gttgattgat agatagagga tcgataactc
    22381 ggaaataata aagtaaaatc tctctgagtg acacttcctt ctcatcgtaa atcacttgga
    22441 ccgtttctgc atggtctgtt tccttgagca actggtaatt ggtcgtttcg acttgaccat
    22501 tagcgtagcc aacactggtt tctagcactc cagaaatgcg tgaaaaatat tcctctaggc
    22561 cccaaaaaca accacctgct agataaattt ctgccatttt tatttctcct
//
