LOCUS       NZ_FEOS01000001        18335 bp    DNA     linear   CON 12-DEC-2024
DEFINITION  Streptococcus pneumoniae strain 2842STDY5881910, whole genome
            shotgun sequence.
ACCESSION   NZ_FEOS01000001
VERSION     NZ_FEOS01000001.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1
  CONSRTM   Pathogen Informatics
  TITLE     Direct Submission
  JOURNAL   Submitted (04-FEB-2016) SC, Wellcome Trust Sanger Institute, CB10
            1SA, United Kingdom
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_900036145.1-RS_2024_12_12
            Annotation Date                   :: 12/12/2024 02:11:13
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.9
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 2,245
            CDSs (total)                      :: 2,193
            Genes (coding)                    :: 2,004
            CDSs (with protein)               :: 2,004
            Genes (RNA)                       :: 52
            rRNAs                             :: 2, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1, 1 (5S, 16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 45
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 189
            CDSs (without protein)            :: 189
            Pseudo Genes (ambiguous residues) :: 0 of 189
            Pseudo Genes (frameshifted)       :: 85 of 189
            Pseudo Genes (incomplete)         :: 105 of 189
            Pseudo Genes (internal stop)      :: 56 of 189
            Pseudo Genes (multiple problems)  :: 48 of 189
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 11:31:24
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 79418
            Orig. end                         :: 97753
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            FEOS01000001.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..18335
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="2"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..18335
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..18335
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:13335](+)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..13335
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     gene            complement(745..1092)
                     /locus_tag="A1178_RS13230"
                     /old_locus_tag="ERS515165_00079"
     CDS             complement(745..1092)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="A1178_RS13230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="ERS515165_00079"
                     /product="hypothetical protein"
                     /protein_id="WP_050209197.1"
                     /transl_table=11
                     /translation="MKIKEQTRKLAAGCSKHCFEVADRTDEVSSKHCFEVVDGTDEVSS
                     KHCFKVVDGTDEVSSKHCFKVVDGTDKVSSKHCFEVVDRTDEVSSKHCFEVVDRTDEVS
                     NHIRQGDVDVV"
     gene            complement(1142..1774)
                     /locus_tag="A1178_RS00425"
                     /old_locus_tag="ERS515165_00080"
     CDS             complement(1142..1774)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HAD_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1115: HAD-superfamily hydrolase, subfamily IA,
                     variant"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000200889.1"
                     /locus_tag="A1178_RS00425"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS515165_00080"
                     /product="HAD family hydrolase"
                     /protein_id="WP_050129035.1"
                     /sec_met_domain="HAD_2 (E-value: 2.1e-38, bitscore: 126.4,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSITAIFFDLDGTLVDSSIGIHNAFTYTFKELGVPSPDAKTIRG
                     FMGPPLESSFATCLSKDQISEAVQIYRSYYKAKGIYEAQLFPQIIDLLEELSSSYPLYI
                     TTTKDTSTAQDMAKNLEIHHFFDGIYGSSPKAPHKADVIHQALQTHQLAPEQAIIIGDT
                     KFDMLGARETGIQKLAITWGFGEQADLLNYQPDYIAHKPLEVLAYFQ"
     gene            complement(1796..2668)
                     /gene="sdaAA"
                     /locus_tag="A1178_RS00430"
                     /old_locus_tag="ERS515165_00081"
     CDS             complement(1796..2668)
                     /EC_number="4.3.1.17"
                     /GO_function="GO:0003941 - L-serine ammonia-lyase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006094 - gluconeogenesis [Evidence IEA]"
                     /GO_process="GO:0006565 - L-serine catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="sdaAA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000500050.1"
                     /locus_tag="A1178_RS00430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS515165_00081"
                     /product="L-serine ammonia-lyase, iron-sulfur-dependent,
                     subunit alpha"
                     /protein_id="WP_000500040.1"
                     /transl_table=11
                     /translation="MFYSIKELVEQADLDFQGNVAELMITTEFELTGREREEVFLLMER
                     NLEVMKASVQLGLNENKSRSGLTGGDAAKLDHYIKNEKTLSDYTILSAARNAIAVNEHN
                     AKMGLVCATPTAGSAGCLPSVLTAAIEKLDLSHEQQLDFLFAAGAFGLVIANNASISGA
                     EGGCQAEVGSASAMSAAALTLAAGGTPYQASQAIAFVIKNMLGLICDPVAGLVEVPCVK
                     RNAMGASFAFIAADMALAGIESKIPVDEVIDAMYQVGASMPTAFRETAEGGLATTPTGR
                     RLQKEIFGE"
     misc_feature    2652..2668
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 24.79"
                     /tool="antismash"
     gene            complement(2677..3348)
                     /gene="sdaAB"
                     /locus_tag="A1178_RS00435"
                     /old_locus_tag="ERS515165_00082"
     CDS             complement(2677..3348)
                     /EC_number="4.3.1.17"
                     /GO_function="GO:0003941 - L-serine ammonia-lyase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006094 - gluconeogenesis [Evidence IEA]"
                     /GO_process="GO:0006565 - L-serine catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="sdaAB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015606087.1"
                     /locus_tag="A1178_RS00435"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS515165_00082"
                     /product="L-serine ammonia-lyase, iron-sulfur-dependent
                     subunit beta"
                     /protein_id="WP_000838912.1"
                     /transl_table=11
                     /translation="MKSLRFQSVFDIIGPVMIGPSSSHTAGAVRIGKIVSSIFDDTPTE
                     VEFQLFNSFAKTYRGHGTDLALVAGILGMDTDDPEIPNSLEIAHKRGIKIVWTIQKDSN
                     APHPNTTKITVKNAHKTISVTGISIGGGNIQVTELNGFAVSLNMNTPTIIIVHQDIPGM
                     IALVTEALSRYGINIAQMNVTREKAGEKAIMIIEVDSRNCDEAIEEIRKIPHLHNVNFF
                     K"
     misc_feature    3504..3520
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 26.23"
                     /tool="antismash"
     gene            3590..4177
                     /locus_tag="A1178_RS00440"
                     /old_locus_tag="ERS515165_00083"
     CDS             3590..4177
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000843467.1"
                     /locus_tag="A1178_RS00440"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS515165_00083"
                     /product="LysM peptidoglycan-binding domain-containing
                     protein"
                     /protein_id="WP_000836442.1"
                     /transl_table=11
                     /translation="MKSITKKIKATLAGVAALFAVFAPSFVSAQESSTYTVKEGDTLSE
                     IAETHNTTVEKLAENNHIDNIHLIYVDQELVIDGPVAPVATPAPATYAAPAAQDETVSA
                     PVAETPVVSETVVSTVSGSEAEAKEWIAQKESGGSYTATNGRYIGRYQLTDSYLNGDYS
                     AENQERVADAYVAGRYGSWTAAKNFWLNNGWY"
     gene            complement(4229..>4555)
                     /locus_tag="A1178_RS00445"
                     /pseudo=""
     CDS             complement(4229..>4555)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001268160.1"
                     /locus_tag="A1178_RS00445"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="DNA-binding protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="KILQRLEVYKNYQHLYDLRIAILLNLSTLYLYNQDKNMCKQICYT
                     LLEDAKNKKSYDRLAICYVPIGICTDDSKLIQKGFSLLELTEETSMLSHLKKEVEIYYQ
                     AKER"
     misc_feature    complement(4641..4654)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: strong, score: 25.42"
                     /tool="antismash"
     gene            5001..5252
                     /locus_tag="A1178_RS00450"
                     /old_locus_tag="ERS515165_00084"
     CDS             5001..5252
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Lactococcin_972"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001230165.1"
                     /locus_tag="A1178_RS00450"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS515165_00084"
                     /product="lactococcin 972 family bacteriocin"
                     /protein_id="WP_050129034.1"
                     /sec_met_domain="Lactococcin_972 (E-value: 9.1e-32,
                     bitscore: 103.8, seeds: 6, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVCGILATTNALAVWVEGGQWNYGVGWTGTFGYSDYLHSTRYHTA
                     TVRHGGRTSKDYAKPEAWARASIFKFPPTGMEYFYGFE"
     gene            5304..7412
                     /locus_tag="A1178_RS00455"
                     /old_locus_tag="ERS515165_00085"
     CDS             5304..7412
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000723955.1"
                     /locus_tag="A1178_RS00455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS515165_00085"
                     /product="bacteriocin-associated integral membrane family
                     protein"
                     /protein_id="WP_000724257.1"
                     /transl_table=11
                     /translation="MKKISNFCMLLLLLCTTFFVFNVNYTREVVRIQEMGKTVDSLDLY
                     LKDINEPAASVLRFFEDVSKEYKVSIIKTDSGDEVVKSGVFDKDTFPYQEFGISSLDFT
                     TDGEGVYSNKEISNKLGTIPTFLKAKPIQLMTFQTYIKDTSRSLNGRYTITSTQEMDKD
                     RIVQKWSDFFKIDQATLLEPTYKSAVEVINRDLLLSAIVFVLAILLLVLVTVYQPMMEM
                     KRVGVQKLLGFQDRAVLADVVKGNLYLLLGGALVINLGVFFLLDYKPKDLFPMLWLSHF
                     LLLQLYLFISWLTYLLIQKMTISSLLKGFSSFKFGLIFNYVMKIGTTILLTALLIGVGR
                     SLEQENKELAYQQQWVSQGNYLTLETFKLNDNLWQEELAGSGKSTDYFYRFYQDLVEKT
                     QAGYVQSSSLPVKNFVQSEQIQQYQLTDTVDVYYANRNFLKSKGFKLPDTGIKKVILMP
                     ASTKGEEDKNQLLGKLIAFHSMKYEEQQKRTIEEMDVEIAYYEGDWSFFPYSDKRKENL
                     SNPIISLVNDSDMMWDEKASLSTTGLNNPIKIENTVQHQKEITELVEKLSDGNYLKFSS
                     IQAIQQEKVDSYRDAVRNFNLLFALFGLLSMMISYFLLVTTFLLKRRDIITKKFMGWKL
                     VDRYRPLLVLLLLGYSFPLLVLIFFAHAFLPLLLFAGFTCLDILFVLGLASRMEKRSLV
                     ELLKGGIL"
     gene            7409..8050
                     /locus_tag="A1178_RS00460"
                     /old_locus_tag="ERS515165_00086"
     CDS             7409..8050
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000571330.1"
                     /locus_tag="A1178_RS00460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS515165_00086"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_000571330.1"
                     /transl_table=11
                     /translation="MIELKNITKTIGGKVILDNLSLRIDQGDLVAIVGKSGSGKSTLLN
                     LLGLIDGDYSGRYEIFGQTNLAVNSAKSQTIIREHISYLFQNFALIDDETVEYNLMLAL
                     KYVKLPKKDKLKKVEEILERVGLSATLHQRVSELSGGEQQRIAVARAILKPSQLILADE
                     PTGSLDPENRDLVLKFLLEMNREGKTVIIVTHDAYVAQQCHRVIELGEGK"
     misc_feature    complement(8156..8170)
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 22.38"
                     /tool="antismash"
     gene            8256..9062
                     /locus_tag="A1178_RS00465"
                     /old_locus_tag="ERS515165_00087"
     CDS             8256..9062
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1091: glutamine-binding lipoprotein glnH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001038484.1"
                     /locus_tag="A1178_RS00465"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS515165_00087"
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="WP_001038474.1"
                     /transl_table=11
                     /translation="MNKMKKVLMTMFGLVMLPLLFACSNNQSAGIEAIKSKGKLVVALN
                     PDFAPFEYQKVVDGKNQIVGSDIELAKAIATELGVELELSPMSFDNVLASVQSGKADLA
                     ISGVSKTDERSKVFDFSTPYYTAKNKLIVKKSDLATYQSVNDLAQKKVGAQKGSIQETM
                     AKDLLQNSSLVSLPKNGNLITDLKSGQVDAVIFEEPVAKGFVENNPDLAIADLNFEKEQ
                     DDSYAVAMKKDSKELKEAVDKTIQKLKESGELDKLIEDAFKASIEK"
     gene            9079..>9471
                     /locus_tag="A1178_RS00470"
                     /old_locus_tag="ERS515165_00088"
                     /pseudo=""
     CDS             9079..>9471
                     /GO_function="GO:0004055 - argininosuccinate synthase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0006526 - L-arginine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002269502.1"
                     /locus_tag="A1178_RS00470"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="ERS515165_00088"
                     /product="argininosuccinate synthase domain-containing
                     protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MSKEKVILAYSGGLDTSVAITWLKKDYDVVAVCMDVGEGKDLDFI
                     HDKALKVGAVESYVIDVKDEFATDYVLVALQSHAYYEQKYPLVSALSRPLISKKLVEIA
                     HQTGATTIAHGCTGKGNDQVEYQIAVA"
     gene            complement(9787..10650)
                     /locus_tag="A1178_RS00475"
                     /old_locus_tag="ERS515165_00089"
     CDS             complement(9787..10650)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001268160.1"
                     /locus_tag="A1178_RS00475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS515165_00089"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_001268172.1"
                     /transl_table=11
                     /translation="MRYDFGKVYKEIRESKGLTQEEVCGGVLSRTSLSKIESGKTTPKY
                     ENMEFLLRQINMSFEEFEYICQLYQPSQRTEIMQTYLNMRSIIGTSDLVNLFQKCQDYL
                     KTHHDLPIEEIRDMLEVVIYLRQHGAGELSKHAEQVVKKLWKKIEKQDTWYESDLKILN
                     TILFSFPIEYLHLITGKILQRLEVYKNYQHLYDLRMTILLNLSTLYLYNQDKNMCKQIC
                     YTLLEDAKNKKSYDRLAICYVRIGICTDDSKLIQKGFSLLELTEETSMLSHLKKEVEIY
                     YQAKER"
     gene            11116..13335
                     /locus_tag="A1178_RS00480"
                     /old_locus_tag="ERS515165_00090"
     CDS             11116..13335
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: TIGR01193"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001856353.1"
                     /locus_tag="A1178_RS00480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS515165_00090"
                     /product="peptidase domain-containing ABC transporter"
                     /protein_id="WP_050129033.1"
                     /sec_met_domain="Peptidase_C39 (E-value: 1e-31, bitscore:
                     103.7, seeds: 36, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR01193 (E-value: 1.2e-170, bitscore:
                     563.5, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLKKYPCTMQHDQSDCAAAVVSTVLLSYKKELSIMKIREIIGTDM
                     YGTTVSGIVSGLNKLNFTVKAVRVALEDLTPKLTFPAILQVKNDLGQNHFVVLHSIKRN
                     SKFYVADPASGIRKMSSDELGEIYQGITLFMVPNSDFERGKLKGKGLLDLFGRLIFNQK
                     GLISTVILASFVLSIIGILSSLFSKVIMDEVIPYALKNSLYMFLIVFGIVSFLQTLLSA
                     FRQHVLLFLSRKIDIPVLMGYYDHIIHLPYSFFGSRRVGDVLTRFQDAMTIKNVFTSVS
                     ISLVMDITLSVISAVVLWTINQSLFLILVFMVIVNIILIYCFKKPYKKINHEQMEANGL
                     LNSQLIESIRNIDTIKSQHDEEQRLNKIEEKFVHTLEIGYKEGVLQNIQSTISSMTSTM
                     GGLLFMGVGALFIIDGKMTIGDLLVFQTLSQYFTEPIQNLVGLQLTFQEVQVAVSRLQE
                     LMEVDREDIALDYSIRDFTLCDDIEFKDVTFAYGSRPPVIKDFNLRIKQGEKIAFVGES
                     GAGKSTLVRLLLRFINPSEGKIRIGENDLSDLDYGKLRKKISYIPQTIELFTGTIIDNL
                     KIGNPSVTYEDMVRVCRIVGIHDTIQRLQNRYGSFVEEGGQNFSGGEKQRLAIARALLS
                     KADLYIFDEATSNLDSFSEQIIQDLIFNKIIDKTTIVVAHRLSTILRCDKICFLENGTI
                     VEYGTHEELMAKNGKYARMVGLQSVQVNQQIQSQAVLDIEEVTYG"
     gene            13328..13795
                     /locus_tag="A1178_RS00485"
                     /old_locus_tag="ERS515165_00091"
     CDS             13328..13795
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001096140.1"
                     /locus_tag="A1178_RS00485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS515165_00091"
                     /product="hypothetical protein"
                     /protein_id="WP_001096141.1"
                     /transl_table=11
                     /translation="MAKLEVKDNKKLVLKSVICKKLHDTKVEDVDQEINKFHQHLQLLK
                     AQIFGPLIVKSCGTTIHDDGLITTDFEFYIQAHNAQQYSNIYDVQDSISVPYCLYVRFE
                     DSPEYLQYAYSKLDLYVYENDIQTDGIVYTVYVNSSPEKMVVDIFRPIVSL"
     gene            13792..15144
                     /locus_tag="A1178_RS00490"
                     /old_locus_tag="ERS515165_00092"
     CDS             13792..15144
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001865356.1"
                     /locus_tag="A1178_RS00490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS515165_00092"
                     /product="HlyD family efflux transporter periplasmic
                     adaptor subunit"
                     /protein_id="WP_000781019.1"
                     /transl_table=11
                     /translation="MKLYNKSELRYSRIFFDKRPPAFAFILIISTAIILSGALVGAAYI
                     PKNYIVKANGNSVITGTEFLSAIGSGKVVTLHKSEGDMVNAGDVIISLSSGQEGLQASS
                     LNKQLEKLRAKEAIFQKFEQSLNEKYNHLSNSGEEQEYYGKVEYYLSQLNSENYNNGTQ
                     YSKIQDEYTKLNKITAERNQLDADLQALQNELLQLQQQGDSPSLSDTTSADDKAKLETK
                     ISEITTKIEALKTNITSKNSEIDSQQSNIKDMNRTYNNPTSQAYNIYAQLISELGTARS
                     NNNKSITELEANLGVATGQDKAHSILAPNEGTLHYLVPLKQGMSIQQGQTIAEVSGKEK
                     GYYVEAFVLASDISRVSKGAKADVAITGVNSQKYGTLKGQVRQIDSGTISQETKEGNIS
                     LYKVMIELETLTLKHGSETVVLQKDMPVEVRIVYDKETYLDWILEMLSFKQ"
     gene            15292..15597
                     /locus_tag="A1178_RS00495"
                     /old_locus_tag="ERS515165_00093"
     CDS             15292..15597
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000420335.1"
                     /locus_tag="A1178_RS00495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS515165_00093"
                     /product="SPAR17_0115 family bacteriocin-like peptide"
                     /protein_id="WP_000420335.1"
                     /transl_table=11
                     /translation="MELILPNNYVDLEQEEMMYLDGGEPMSISAIVALAITIGGASYST
                     GYVLGERVYYSGYKNSDYQKNKWGIRGAMLAAFGAIGAVVMLGFENRYYALVTGRG"
     misc_feature    complement(15320..15333)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: medium, score: 21.57"
                     /tool="antismash"
     gene            15931..16284
                     /locus_tag="A1178_RS00500"
                     /old_locus_tag="ERS515165_00095"
     CDS             15931..16284
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000424445.1"
                     /locus_tag="A1178_RS00500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS515165_00095"
                     /product="hypothetical protein"
                     /protein_id="WP_000424408.1"
                     /transl_table=11
                     /translation="MELVLPNNYVALEQEEMMYLDGGAYLSKRACQGICAALAMSPGTF
                     IALAGAAVLTKKLINYIKVGGLGGWLIGAAAGVLAGAAGRIAYCIGYGALNRGCDISGN
                     PYPWDGFISATVR"
     gene            16281..17009
                     /locus_tag="A1178_RS00505"
                     /old_locus_tag="ERS515165_00096"
     CDS             16281..17009
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001866696.1"
                     /locus_tag="A1178_RS00505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS515165_00096"
                     /product="hypothetical protein"
                     /protein_id="WP_057526218.1"
                     /transl_table=11
                     /translation="MSNVDKIRKIHIIVCWMYIFLSFRAIINDTEYFLLIFLAFIYSIV
                     SLPLYSVKNKIVSICLAINSILLMSFPILINKFFPESFLTYTVLISVFITELIIFHLIG
                     KDFDIKLTNEYKKISQFRSKVSQSPWIKYLEISSFILTIFPSILYGTVANHVLTLIFLI
                     KICVDTTIKFLFIRLFDTSTLMKRRIFFLFALDVIAYLFLGYLLVIQKAGYLFSVLLLF
                     SNFSVPFIKEKEYELFKNSK"
     gene            17495..17686
                     /locus_tag="A1178_RS13235"
     CDS             17495..17686
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000680090.1"
                     /locus_tag="A1178_RS13235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_073176647.1"
                     /transl_table=11
                     /translation="MFFAGIGEIKLVGYLLYICVGLAPLFHIYVIGSELSFVKIVLSIL
                     GVIFVSMLTIARIYRTFL"
     misc_feature    17704..17722
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: medium, score: 25.52"
                     /tool="antismash"
ORIGIN
        1 cttacaatgt tgctagagcc gttgatgaag ccaaggtgcc taagatggtt atgatttcga
       61 cagataaggc agttaatcca ccaaatgtta tgggagcaac caagcgcgtg gcggagttga
      121 ttgtcactgg ctttaaccaa cgtagccaat caacctactg tgcagttcgt tttgggaatg
      181 ttcttggtag ccgtggtagt gtcattccag tctttgaacg tcagattgct gaaggtgggc
      241 ctgtaacggt gacagacttc cgcatgaccc gttactttat gaccattcca gaagctagcc
      301 gtctggttat ccatgctggt gcttatgcca aagatgggga agtctttatc cttgatatgg
      361 gcaaaccagt caagatttat gacttggcca agaagatggt gcttctaagt ggccacactg
      421 aaagtgaaat tccaatcgtt gaagttggaa tccgcccagg tgaaaaactc tacgaagaac
      481 tcttggtatc aaccgaactc gttgacaatc aagttatgga taagattttc gttggtaagg
      541 ttaatgtcat gcctttagaa tccatcaatc aaaagattgg agagttccgc actctcagtg
      601 gagatgagtt gaagcaagct attatcgcct ttgctaatca aacaacccac attgaataaa
      661 aaagaaaaac gcatagtatc aagtttgtta accttggtac tatgcgtttt attatgtaga
      721 gacttatact cttcgaaaat ctcttcaaac cacgtcaacg tcgccttgcc gtatatggtt
      781 actgacttcg tcagttctat ccacaacctc aaaacagtgt ttagagctga cttcgtcagt
      841 tctatccaca acctcaaaac agtgtttaga gctgactttg tcagttccat ctacaacctt
      901 aaaacagtgt ttagagctga cttcgtcagt tccatctaca accttaaaac agtgtttaga
      961 gctgacttcg tcagttccat ctacaacctc aaaacagtgt ttagagctga cttcgtcagt
     1021 tctatctgca acctcaaaac agtgtttaga gcagcccgca gctagtttcc tagtttgctc
     1081 tttgattttc attgagtatt acttcatttt cttctgaaat ggaattgtta cccagtctat
     1141 gctattgaaa atacgccaaa acttctaagg gtttgtgagc gatataatca ggttgatagt
     1201 ttagtagatc tgcttgctct ccaaatcccc aagtgatggc caatttctga atacctgttt
     1261 ctcgagctcc cagcatatca aacttggtat ctccgatgat gatggcttgt tctggtgcta
     1321 gttgatgtgt ctgcaaggct tggtgaatga catctgcctt atggggtgct ttagggctag
     1381 aaccataaat gccatcaaag aaatgatgga tttccaagtt ttttgccatg tcttgagcag
     1441 tagatgtatc ctttgtcgtg gtgatgtaga gtggataact gctcgataac tcctcaagca
     1501 agtctataat ctgaggaaag agttgagctt catagatgcc ttttgcctta tagtaagaac
     1561 gatatatctg cacggcttca gaaatttggt ctttggacag gcaggtcgca aaactacttt
     1621 cgagaggtgg tcccataaaa ccacgaatag ttttggcatc agggctaggc acccccagct
     1681 ctttaaaggt ataggtaaag gcattgtgaa tcccgataga actatcaacg agggttccat
     1741 ccaaatcgaa aaaaatcgct gtgatagagg tcatggtttc tcctatttga taagcttatt
     1801 ctccgaaaat ttctttttgg aggcgacgac cagtaggggt ggtagcgagt ccaccttcag
     1861 ctgtttcacg aaaggcagtt ggcatgcttg ctcctacttg gtacatggca tcgatcactt
     1921 catccacagg gattttagat tcgatacctg ccaaggccat gtctgctgcg atgaaagcaa
     1981 agctagctcc catggcatta cgtttgacac agggaacttc gaccaaacct gcaacagggt
     2041 cacagatgag gcctagcata tttttaatga caaaggcaat agcttgactg gcctgataag
     2101 gtgttccacc tgcagccaga gtcaaggcgg cagcactcat agcagaggct gaaccaactt
     2161 cagcttgaca cccaccctca gcacctgaga tggaggcatt gtttgcgatg actagtccaa
     2221 aggcaccagc agcaaagagg aaatccaatt gttgctcgtg gctgaggtct aatttttcaa
     2281 tagcagcagt gagaacggat ggcagacagc cagcacttcc agcggttgga gtggcacaga
     2341 ccaagcccat tttggcattg tgttcattga ctgcgatggc atttcgggca gcagagagaa
     2401 tcgtgtaatc tgataaagtt ttttcgtttt tgatgtagtg gtccaatttg gcagcatctc
     2461 cacctgtcag gccactacga gatttatttt cattgaggcc aagttggaca gaggctttca
     2521 taacttccag attgcgttcc atgagaagga agacttcttc acgttcgcga ccggtcaatt
     2581 caaactctgt tgtaatcatg agttctgcga catttccttg aaagtccaga tctgcttgct
     2641 cgaccaattc tttgatagaa taaaacatgc ttcctcctat ttaaagaaat tgacattgtg
     2701 gagatgaggg atttttcgaa tttcttcgat agcctcatca cagttgcgac tgtcaacttc
     2761 gataatcata atggcttttt caccagcttt ttcacgagtg acattcatct gggcgatatt
     2821 gataccatag cgggaaagcg cctctgtaac aagggcaatc atacctggaa tatcttgatg
     2881 aacgatgatg atagtcggtg tattcatatt gagagagacg gcaaaaccat tgagttcggt
     2941 tacttgaata tttcctccac cgatagaaat accagtcacg ctgatggtct tgtgggcatt
     3001 tttaacagta attttagtgg tgttagggtg aggggcattg ctgtctttct gaatggtcca
     3061 gacaatcttg ataccacgct tgtgggcaat ttccagacta tttggaattt caggatcatc
     3121 tgtatccatt cctaaaatac ctgcaacaag ggctaggtct gttccgtgac cacgataggt
     3181 cttggcaaat gagttaaaaa gttggaattc aacttctgtc ggagtatcat caaaaatgga
     3241 agagacaatc ttcccaatac gaacagcacc agcggtatgg ctactagatg ggccaatcat
     3301 aactggtccg atgatatcaa agacagattg aaaacgaagt gatttcatca gtttcccctt
     3361 ataaaaattc ttatctctat tatatcaaag aatgaggggc ttggctttaa ttgtggatga
     3421 aaacctttct aatacctcaa atagcataaa aatagtatct tttatgacaa aaaacacctt
     3481 atttagggaa ataaaaaata attttgtaat atttctacat aaaagtgtca agaaacggta
     3541 atatttaaag ggtatgatag aactatagaa agaaggagaa ttttcgaata tgaaatcaat
     3601 aactaaaaag attaaagcaa ctcttgcagg agtagctgcc ttgtttgcag tatttgctcc
     3661 atcatttgta tctgctcaag aatcatcaac ttacactgtt aaagaaggtg atacactttc
     3721 agaaatcgct gaaactcaca acacaacagt tgaaaaattg gcagaaaaca accacattga
     3781 taacattcat ttgatttatg ttgatcaaga gttggttatc gatggccctg tagcgcctgt
     3841 tgcaacacca gcgccagcta cttatgcggc accagccgct caagatgaaa ctgtttcagc
     3901 tccagtagca gaaactccag tagtaagtga aacagttgtt tcaactgtaa gcggatctga
     3961 agcagaagcc aaagaatgga tcgctcaaaa agaatcaggt ggtagctata cagctacaaa
     4021 tggacgttat atcggacgtt accaattaac agattcatac ctgaacggtg actactcagc
     4081 tgaaaaccaa gaacgtgtag cagatgccta cgttgcagga cgttacggtt catggactgc
     4141 tgctaaaaac ttctggctta acaatggctg gtattaagaa ctaacgaaca aataatatgt
     4201 aaagagtcga ggaaatccct cggctttttt atctttcctt cgcttggtaa tagatctcta
     4261 cttctttttt gagatgagac agcatagaag tttcctcggt tagctccaga agggagaacc
     4321 ctttttggat aagtttagaa tcgtctgtac aaatcccaat agggacatag cagatagcca
     4381 gcctatcgta gcttttctta ttcttggcgt cctctagtaa agtgtagcag atttgcttac
     4441 acatgttttt atcttgattg tatagataga gtgtggaaag gttgagcagg attgctattc
     4501 gcaagtcata taaatgttga tagtttttat agacttctaa gcgttgcaag attttctcgg
     4561 attattgaca aataaacgga cattctgata gacgattgcc ctagcggctt attgtaaact
     4621 ttgcaaattt ggcttgtaat tttttttata aaattcactt cgattacttg acagttatta
     4681 tattttcact tattatatag ataaaaggat gggataagag tttaaaaatt tgaaagcgct
     4741 atccatattg tttattgggc tgattcttga gtaatagtta gagtgtgatt aatactactc
     4801 tggttgttca aagacctgat acagaagaga actattctcc tagttaagag taagttcgtt
     4861 gtttaaaaat gaaatgagat agaaggaagg tgagtccaat ggactacgat acttgttgac
     4921 aaattactat agctgtttct acggaatagc tctcgataat aggagaaata aatcatgaga
     4981 aaattggtgt tgcatcttta atggtatgtg gtatacttgc tactacaaat gctttagcag
     5041 tatgggttga gggtggtcaa tggaactatg gagtaggttg gacaggaact tttggatatt
     5101 ctgattactt acattctact cgatatcata cagcaactgt tagacatggg ggtagaacct
     5161 ctaaggatta tgcaaaacct gaggcatggg ctcgggcttc aatcttcaaa ttcccaccaa
     5221 cgggaatgga atatttctat ggatttgagt aaaattcttc cctctcctat ttggagaggg
     5281 aaaactgtag tggaggcact tttatgaaaa aaatcagtaa tttctgtatg ttactcctgc
     5341 ttctgtgtac cacttttttt gtttttaatg taaactatac acgagaagtg gttcggattc
     5401 aagaaatggg aaagactgta gattctttgg atttgtattt gaaagatatt aacgaacctg
     5461 cagcgtctgt tcttcgattt tttgaggatg tatcaaagga gtataaagtc tccatcatca
     5521 aaacagacag tggtgatgag gtggtcaagt ctggtgtttt tgataaagat accttcccct
     5581 accaagagtt tgggatttct tctcttgatt ttaccacaga tggtgaagga gtctatagta
     5641 ataaagaaat ttccaataaa cttggtacga ttccgacctt tctaaaagcc aaacctattc
     5701 agcttatgac ttttcaaacc tatatcaagg atacatctcg tagtttaaat ggtcgctata
     5761 cgataacttc tacacaagag atggacaagg ataggattgt acagaaatgg agcgattttt
     5821 tcaagataga ccaggctacc ttgctagagc cgacctacaa aagtgcagtg gaagtcataa
     5881 atcgagattt gcttttatct gccattgttt ttgtcttggc tattttgctt cttgtgttag
     5941 tgacagtgta tcaaccgatg atggagatga aaagagttgg ggtacaaaaa ttacttggtt
     6001 ttcaagatag ggctgtttta gctgatgttg taaaaggcaa cctttacctc ctcctaggtg
     6061 gggctcttgt gatcaatcta ggcgtgtttt tcttgcttga ttataagcca aaagatttgt
     6121 ttcctatgct gtggttgtct cattttttgc tgttgcagct ttatctcttt atcagttggt
     6181 tgacttacct cttaatccaa aaaatgacaa tcagctctct gctgaaaggt ttttcatctt
     6241 tcaaatttgg tcttatcttc aattatgtga tgaaaatagg gacaactatt ttactgacgg
     6301 ccttactgat tggggtgggc agaagtttag aacaagaaaa caaagaactt gcttatcagc
     6361 aacagtgggt aagtcaaggt aattacctga ccttagaaac cttcaaactc aatgataatc
     6421 tgtggcaaga agagctagca gggtcaggga aatctacaga ttatttctat cgattttatc
     6481 aggatttggt agaaaaaacg caggcgggct atgtgcagag tagcagtctt cctgtaaaaa
     6541 attttgtcca atcagaacag attcagcaat atcagttaac agatacggtg gatgtttact
     6601 atgccaatcg caattttcta aagagcaagg gattcaagct accagatacc ggtattaaaa
     6661 aagttatttt gatgccagca agtacgaaag gtgaagaaga taaaaatcag ctcttgggga
     6721 agttaattgc ctttcattcg atgaagtatg aagagcagca aaaacgaacg atagaggaga
     6781 tggatgtcga gattgcctat tatgaaggag attggtcatt tttcccatat agtgataagc
     6841 gaaaggaaaa tctctccaat ccaattatta gcttggtcaa tgattctgat atgatgtggg
     6901 atgagaaagc ctccctgtca acaactggct taaataatcc gattaaaatt gaaaatacgg
     6961 ttcaacatca aaaagagatt acagagttag ttgagaaatt gtcagatgga aattatttaa
     7021 aattttcatc tattcaagcc attcaacaag agaaagtgga ttcttataga gatgctgttc
     7081 ggaattttaa cctactcttt gctttgtttg gtctccttag catgatgatt tcctacttct
     7141 tactagtaac aactttctta ttgaagcgca gggatatcat taccaagaag tttatggggt
     7201 ggaaactggt cgatcgctac cgtcctctcc tcgttctgct cttgctgggc tatagtttcc
     7261 ctcttctagt cttgattttc tttgcccatg cgttcttacc acttctactg tttgcaggtt
     7321 ttacatgtct ggatatacta tttgtgctag gcttagcttc taggatggag aaaagaagtc
     7381 tagtagagtt attgaaaggg ggcatcttat gattgagttg aaaaatatta ccaaaaccat
     7441 tgggggaaaa gtgattttgg ataacttatc tctcaggatt gatcaggggg atttggtagc
     7501 tattgttggt aagagtggta gtgggaagtc gaccttgtta aatttattgg gtttgataga
     7561 tggtgattat agcggacggt atgagatttt tggtcagaca aatctagcgg ttaattctgc
     7621 taagtcgcaa acaataatcc gtgaacatat ctcttatctg tttcaaaatt ttgccctgat
     7681 tgatgatgaa acggtcgagt acaatctcat gctggcgctg aaatatgtga aattgcctaa
     7741 gaaagacaag ctcaaaaagg tggaagagat tttagagaga gtaggtttgt cagctacttt
     7801 gcatcaaagg gtctccgagt tgtctggggg cgaacaacaa cgaattgcag ttgctagagc
     7861 catcttaaaa cccagccagc tgattttagc cgatgaacct acaggttcgc tggatcctga
     7921 aaatagagat ttggtcttga agtttctctt agagatgaat cgagaaggga aaacagtcat
     7981 tattgtgacc cacgatgctt atgtagccca acaatgtcat cgtgtcattg aattgggcga
     8041 gggaaaatga gttcattcag ctccttttga ctggctgaat actcatgttt tccagagaaa
     8101 aatggcataa atacgcctag gaatgacatt ttatgtagta tttctaggtt tttttgtttc
     8161 aaattgaaaa ttttttcaat ttaggcttga caaaggatga gtataggagt attatttata
     8221 caataaaaaa gaataaacat aaaggaggct ttgttatgaa taagatgaag aaggtgttga
     8281 tgacgatgtt tggtttagtg atgctccccc tactatttgc ttgtagtaac aatcaatcgg
     8341 ctggaattga agccatcaag tccaaaggaa aattggttgt agccctcaat ccagattttg
     8401 ctccatttga atatcaaaaa gtggttgatg ggaaaaatca gattgtgggt tcagatatcg
     8461 aattagccaa ggctatcgca acagaactag gtgtcgaatt ggaactatct cctatgagtt
     8521 ttgacaatgt actggctagc gttcaatcag gaaaagctga ccttgccata tcaggtgttt
     8581 ctaagacaga tgaacggagc aaggtgtttg atttttcaac tccctactat actgcaaaaa
     8641 ataaactcat tgtcaaaaaa tctgatttag ccacttatca gtctgtcaac gatttggcgc
     8701 agaaaaaggt cggagcgcag aaaggttcga ttcaagagac gatggcgaaa gatttgctac
     8761 aaaattcttc cctcgtatct ctgcctaaaa atgggaattt aatcacagat ttaaaatcag
     8821 ggcaagtgga tgccgttatt tttgaagaac ccgttgccaa gggatttgtg gaaaataatc
     8881 ctgatttagc aatcgcagac ctcaattttg aaaaagagca agatgattcc tatgcggtag
     8941 ccatgaaaaa agatagcaag gaattgaaag aggcagtcga taaaaccatt caaaagttga
     9001 aggagtctgg ggaattagac aaactcattg aggatgcctt taaagcgtcc attgaaaaat
     9061 agaaagaagg aaaagaacat gagtaaagaa aaagtaattt tggcctattc tggcggttta
     9121 gacacatcag ttgctattac ctggctgaag aaagactatg atgttgttgc agtttgtatg
     9181 gatgtgggtg aagggaaaga cttagatttc atccatgata aggctcttaa ggttggggca
     9241 gtcgaatctt atgtcattga tgttaaggac gaatttgcta cagattatgt gctagtagct
     9301 ctccagtcac atgcctacta tgaacaaaag taccccttgg tatctgcctt gagccgccct
     9361 cttatttcta aaaaattggt tgaaatagcg catcagacag gagcgactac aattgctcat
     9421 ggttgtacag gtaaggggaa tgaccaagtc gaataccaga ttgcagtcgc taagaaagcg
     9481 aatgaagcta aaaagtgatg gagtgatggg ttcagaataa gaggttggtc aattggcagc
     9541 ctctttcttg tcgttgaaaa agtgagatat attgactttt gaaaaaaatg tcataattga
     9601 gtttggataa acgtaaaagt catactttct cgttaaatcg ttcggcgatt catggtgaca
     9661 tggacacata gtagtaaaca cactatgtgg cttggcagag ctaaaaactt ctggtttaac
     9721 aatggctggt attaagaact aacgaacaaa taatatgtaa agagtcgagg aaatccctcg
     9781 gcttttttat ctttccttcg cttggtaata gatctctact tcttttttga gatgagacag
     9841 catagaagtt tcctcggtta gctccagaag ggagaaccct ttttggataa gtttagaatc
     9901 gtctgtacaa atcccaatac ggacatagca gatagccagc ctatcgtagc ttttcttatt
     9961 cttggcgtcc tctagtaaag tgtagcagat ttgcttacac atgtttttat cttgattgta
    10021 tagatagagt gtggaaaggt ttaatagaat tgtcattcgc aagtcatata aatgttgata
    10081 gtttttatag acttctaggc gttgcaatat ttttccagtg atgagatgga ggtattcaat
    10141 gggaaaactg aaaagaatgg tattgaggat ttttagatca ctctcatacc atgtatcttg
    10201 tttttcaatt tttttccaaa gttttttgac aacctgttct gcgtgttttg atagttcccc
    10261 tgccccgtgt tgacggagat aaataacaac ttcaagcata tctctgattt cttctatagg
    10321 gagatcgtgg tgggtcttga ggtagtcttg gcatttttga aataaattga caagatcgct
    10381 ggtcccgata atggaacgca tattgagata ggtttgcata atctctgtgc gttgacttgg
    10441 ttgataaagt tgacagatat attcaaactc ttcaaaactc atattgattt gacggagaag
    10501 aaattccata ttttcatatt ttggggttgt cttgccactt tcgatttttg ataagctggt
    10561 tcttgagaga acacccccac agacctcttc ttgggtcagc ccctttgact cacgtatttc
    10621 tttatagacc tttccgaaat cataacgcat gattttctcc ttttcgtgaa aaaagttaac
    10681 aaacaataaa attttgttaa aaatattgta tcatagcaat gtaaaaagta aaaaagaaag
    10741 tcgaaataaa tttgtgaaaa aagttaacgt aattttaaaa tgagcttaat aagaggtact
    10801 atgtaggtag aaaataaaga taggagaaaa agtatgaata aaaaaatatt ttgtattcta
    10861 gtatgtatta tattattgat tagtctggct ataatctttc catggggctg gccgatataa
    10921 tgtaagggag tttgagttgt taaaggaggc tcagtccttg ggcaaaaatc tgctgtacta
    10981 caatgcttgg aaagatatca agaacaaaga atgatacggt tgaaaataaa ttaattcaag
    11041 aactactggg cagtgattga ggtttgggtg acatcaaaga aaagttagat taattctaaa
    11101 gaattgagta tttctatgtt aaaaaaatat ccttgtacga tgcaacatga ccagtcagat
    11161 tgtgctgcgg cagttgtttc aacagttctt ttatcttaca aaaaggaact atcaatcatg
    11221 aagattaggg aaattattgg tacagacatg tatggaacga ctgtcagtgg tattgtttca
    11281 ggtctgaata agttgaattt tacagtaaaa gctgttcgag tagcactgga agatttgact
    11341 ccaaaattaa catttcctgc gattcttcaa gttaagaatg atttaggtca aaatcatttt
    11401 gtggtattac atagtatcaa aaggaatagt aagttctacg tagcagaccc tgctagtggc
    11461 atacgcaaga tgtcaagtga cgaactggga gaaatttatc aaggtattac tctttttatg
    11521 gttccaaatt cggattttga aagagggaaa ctaaagggaa aaggacttct tgatttattt
    11581 ggaaggttaa tttttaatca aaaaggattg attagtacag tcatattagc ttcctttgtt
    11641 ttaagtatca ttggtatttt atcgagtctc ttttcaaaag ttatcatgga cgaggtgatt
    11701 ccatatgctt taaaaaatag tctgtatatg tttttgatag tatttggaat agtgtcgttc
    11761 ttacagactc ttctatctgc atttcgtcag cacgttcttt tgtttctatc tcgaaaaatt
    11821 gatataccgg ttttaatggg atattatgac catattattc atcttcctta tagttttttt
    11881 ggaagtcgta gagttggtga tgttttaacg agatttcaag atgcgatgac gataaagaat
    11941 gtgtttacgt cagtctctat ttcattagtc atggatatca ccttgtcagt tattagtgcg
    12001 gttgtccttt ggactattaa tcaatcttta tttctgatat tagtttttat ggttattgtt
    12061 aacatcattc ttatatactg ttttaaaaag ccttataaaa aaattaatca tgaacaaatg
    12121 gaagcaaatg gacttcttaa ttcacagtta attgaatcta ttcgtaacat tgataccatt
    12181 aagtctcagc atgacgagga acaacgttta aacaaaattg aagaaaaatt tgttcatact
    12241 ttagaaattg gttataaaga gggtgttttg cagaatattc aatctacaat atcttcaatg
    12301 acctcaacca tgggtgggtt attatttatg ggagtgggcg ccttatttat cattgatgga
    12361 aaaatgacta ttggggacct cttggttttt cagacattaa gtcaatattt tacagaacct
    12421 attcagaatt tagttggctt gcagttaacc tttcaagagg tacaggttgc ggttagtcgg
    12481 cttcaagaat tgatggaagt agatcgtgaa gacattgcct tggattatag tattagagac
    12541 ttcaccttat gtgatgacat tgaatttaaa gatgtaacat ttgcctatgg ttcacgccct
    12601 cctgttatca aggactttaa tttgcgaatt aaacaaggag aaaaaatagc ttttgttgga
    12661 gaaagcggag caggaaaaag tacgctagtt cgtttgttat taagatttat aaatccgagt
    12721 gaggggaaaa ttcgtatagg agaaaatgac ttatcagatc ttgactatgg taaactacgt
    12781 aagaaaattt cctacattcc tcagaccata gaactcttta cagggacaat tattgataat
    12841 ctaaaaattg gtaatccttc tgttacatat gaggatatgg tgagagtttg tcgtattgtt
    12901 ggtattcatg atacgattca acgtcttcaa aatcgttatg gctcctttgt agaagaaggc
    12961 ggtcaaaatt tctcgggtgg agagaaacaa cgattggcta ttgcaagagc actactgagt
    13021 aaagctgatt tgtatatatt tgatgaggca acctctaact tagattcatt tagtgaacag
    13081 attattcagg atttaatctt taataaaata atagataaga caacaattgt agtagcccac
    13141 aggctgtcta caattcttcg atgtgataag atatgctttt tagaaaatgg gactattgtg
    13201 gaatatggga ctcatgaaga actaatggcg aaaaatggaa agtatgctag aatggttggt
    13261 ttgcagagcg ttcaagtgaa tcaacaaatt cagtcacagg ctgtgttaga tatagaggag
    13321 gttacttatg gctaagttag aggtaaaaga taataaaaaa ctggtactaa agtcagttat
    13381 ctgtaaaaag ttacatgata caaaagtaga agatgtagat caggaaatta ataaatttca
    13441 tcaacatttg cagttgttaa aagcacaaat ttttggtcca ttaattgtaa aaagttgtgg
    13501 tactactatt catgatgatg gattaataac gactgatttt gagttttata ttcaagctca
    13561 taatgctcaa cagtacagta acatttatga tgtacaggat tctatctctg ttccatattg
    13621 tttatatgtt cgttttgaag acagtccaga gtatctacag tatgcgtatt ctaaattgga
    13681 tctatatgtc tatgaaaatg atattcaaac ggatgggatt gtctatacag tttatgttaa
    13741 ttcttctcct gaaaaaatgg tagtagatat ttttagacca attgtaagcc tatgaaatta
    13801 tataataaat cagaattacg ttattctcgt attttctttg ataagagacc accagctttt
    13861 gcgtttattc tcattatttc aactgctatt atcttaagcg gtgcattggt tggcgcagct
    13921 tatataccca aaaactatat tgtaaaagcg aatggaaatt cagttataac aggtacagag
    13981 ttcctatcag caattggttc agggaaggta gttactttac ataagtcaga aggagatatg
    14041 gtaaatgctg gagatgtcat tatttcgtta tcaagtggac aagaaggttt acaagcgagc
    14101 tctttaaata aacaattgga gaagttacgt gcaaaagaag ctatctttca aaaatttgaa
    14161 caatcattaa atgagaaata caatcattta tctaattctg gtgaagaaca ggaatattat
    14221 gggaaagttg aatactatct gtctcagtta aactcggaaa attataataa tggtacccag
    14281 tattcaaaga ttcaggatga atatacgaag ttgaataaaa taacagctga aagaaatcag
    14341 ttagatgccg acttgcaagc tctacaaaat gaattgcttc aacttcaaca gcaaggagac
    14401 tcaccttctt tatcagatac gacatcagct gatgataaag ctaagttaga aactaagata
    14461 tcagaaataa caacaaaaat cgaagcatta aaaacaaata ttacttctaa gaatagcgag
    14521 attgatagtc aacaaagcaa tattaaggat atgaaccgta cctataataa tccaacttct
    14581 caggcttata atatttatgc tcaattaatt agtgagttag gtactgctcg ttcaaacaac
    14641 aataaaagta ttacagagct tgaggctaat cttggagtgg caacaggtca agataaagca
    14701 catagtatat tagcgccaaa tgaaggtact ctgcattatc tggtaccttt gaaacaagga
    14761 atgtctattc agcaggggca aacgatagca gaagtttcag ggaaagaaaa aggttactat
    14821 gtagaagctt ttgtacttgc gagtgatatt tctcgtgttt cgaaaggagc aaaagctgat
    14881 gttgctatta ctggtgtaaa tagtcaaaaa tatggaacac taaagggaca agtcagacag
    14941 attgattcag gaacaatttc ccaagaaacg aaagagggga atattagcct ctataaagtc
    15001 atgatagaat tagaaacctt aactctaaaa catggaagtg agacagtcgt cctccaaaag
    15061 gatatgccag ttgaagtgcg gattgtctat gataaagaaa cctatcttga ttggatttta
    15121 gaaatgttaa gtttcaagca ataattggtt ttaaacccct taggtaacct ataaaaataa
    15181 ataaggtaga gaaaggatat cttatctagg tagctaagtg atagaaacac agtcgacgat
    15241 tacttgttag gaaactatcc taaccatgct taataaaaaa ggagaaaata aatggaactc
    15301 atattgccaa ataattatgt tgatcttgaa caagaagaga tgatgtatct tgatggcgga
    15361 gaaccaatgt caatttcggc cattgttgcc ttggctatca caattggtgg cgcatcgtat
    15421 agcacaggat atgtgttagg agaaagagtc tactattcag gatataaaaa ctctgattat
    15481 caaaaaaata agtggggtat taggggagca atgctggctg catttggagc aataggtgca
    15541 gtagttatgc tcggttttga aaatagatac tatgctttgg ttactggtag aggataaaat
    15601 gttaagagta atagtagtta ttcaatcttt agtaataata ctgcttgctg ttgctttatt
    15661 attatctcgg aaaaactttg attcgttaaa tgttgttctt ataatgatga tcgtatcaca
    15721 attgttgtta ttagtatatt tgataaaatt agggaatcag tgattagctg ttatttgaat
    15781 taagtaaact gttaagcttc aagcagtaac tggttttaaa tatttaaaat aagataaagg
    15841 aaggaagtct aatttaggta actaaacaaa gcctgcgatc acttgttagg aaactatcct
    15901 aaccatgctt aataaaaaag gagaaaataa atggaactcg tattaccaaa taattatgtt
    15961 gctcttgagc aagaagagat gatgtatctt gatgggggag cttatttaag caagcgtgct
    16021 tgtcaaggaa tttgcgcagc tttagctatg agtccaggaa cttttatagc attagctgga
    16081 gctgcagttt taaccaaaaa actaataaac tatattaaag ttggaggcct tggaggttgg
    16141 cttattggtg cagcagcagg tgtattggct ggggcggcag gaagaatagc ttactgtatt
    16201 ggatatggtg ctcttaatag aggttgtgat attagcggga acccttatcc ttgggatgga
    16261 ttcatatctg cgacagtaag atgagtaatg tagataagat tcgaaaaata cacattatcg
    16321 tatgttggat gtatatattt ttatcattca gggcgattat aaatgacacg gagtattttt
    16381 tgcttatttt tttagctttt atctactcaa tagtatcact acctctatat tctgtgaaaa
    16441 ataaaatagt atctatctgt ctagccataa attcgattct gttaatgagt ttccccattt
    16501 taatcaataa gtttttccca gaaagttttt tgacttatac cgtattaata agtgttttta
    16561 ttacagagtt gataattttt catttaattg ggaaagattt tgatattaaa ttgactaacg
    16621 aatataagaa aattagtcag tttagaagca aggtgtctca atctccttgg ataaaatatt
    16681 tagagatttc tagttttata ttaactatat ttccatctat tctttatggt acagttgcta
    16741 atcatgtact gactcttatc tttttgataa aaatttgtgt agataccacg ataaaatttt
    16801 tattcatcag attatttgac acaagtactt taatgaagag gagaatattt tttcttttcg
    16861 cattggatgt tatagcttac ttatttttag gatatctttt agtgattcaa aaagcaggct
    16921 atttgttttc ggttttactt cttttttcta atttttcagt tccatttatc aaagaaaagg
    16981 aatacgaatt atttaaaaat agcaagtaat agaaatatgg attaaatctt agaacggctt
    17041 aaaatcagat atgataaagg gaaatagtct tatctaggta actaagtgct acaaacacaa
    17101 tcgaggatca cttgttagga ttacatttta atcatgctta ataagaatgg agaattccta
    17161 tggggattgt attactctga agtttcgaat accttagttc tcgtgatttt gagctattct
    17221 agctttagaa tccttcagaa cgtaaaattt taagcagtca aagacttaga atagcctgaa
    17281 aacatttatt ttatagcaat tctaggctta gaattgctca tatatatgta tttgagctgc
    17341 tcgatagtta ggacagctct attctgagaa atctgagcta tcaatgcttc agaatagtat
    17401 ttcgccaatg gtttttattg aagaggtgat tgttttatga tagtctaaaa taaaactgat
    17461 ttaatggagt aaatggagaa tcgttacatg aaacattttt tttgcaggaa ttggtgagat
    17521 aaaacttgtt ggctacttat tgtatatatg tgtaggacta gcccctcttt ttcatatata
    17581 tgtcataggt tcggaactga gttttgtgaa aatagtgtta tctattttgg gagttatatt
    17641 tgtaagtatg ttaactattg ctcgaattta tcggactttt ctataaagaa tagtttggac
    17701 ttgaactgta tctaaaaaca gaggttggtc gattatcagc ctctttcttg tcgttgaaaa
    17761 gagtgagata tattgacttt tgaaaaaaag atgtcataat tgagttggga taaacctaaa
    17821 agtaatatag tagattgaat ctggaatagt ccgttatgac tgttaaaata tttctagaaa
    17881 ttaatttgac tttcctaatc gatttgttca catcttgttt caatctacta tactttttcg
    17941 ttaaaccgtt cggcaattca tggtgacatg gacacatagt agtaagcaca ctatgtggct
    18001 tggcagagct aaaaactgtt cccttgcgat aagcctaata agcacaacat agggagttag
    18061 agaagccgac tctaatcaac cactttgggc agtagtgaga actgccccgt gcttttttat
    18121 tttgagaaaa tatggagctt gtcgttgaaa ttacttgatt gtattttgga ttatcaagaa
    18181 agattcaatg gaaaaacatg tcaagtatca acgaattata agtatttaga gactttcaaa
    18241 gtgaattttt gcttgactga tttacatcat ttatttggtt tacacaaaat cacacgagat
    18301 tttgctagtc atacgatacc tgctattcaa gctgg
//
