LOCUS       NZ_FDFR01000002        15605 bp    DNA     linear   CON 22-DEC-2024
DEFINITION  Streptococcus pneumoniae strain 2842STDY5753301, whole genome
            shotgun sequence.
ACCESSION   NZ_FDFR01000002
VERSION     NZ_FDFR01000002.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1
  CONSRTM   Pathogen Informatics
  TITLE     Direct Submission
  JOURNAL   Submitted (04-FEB-2016) SC, Wellcome Trust Sanger Institute, CB10
            1SA, United Kingdom
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_900022985.1-RS_2024_12_22
            Annotation Date                   :: 12/22/2024 02:12:38
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.9
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 2,313
            CDSs (total)                      :: 2,259
            Genes (coding)                    :: 2,086
            CDSs (with protein)               :: 2,086
            Genes (RNA)                       :: 54
            rRNAs                             :: 3, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1, 1 (5S, 16S, 23S)
            partial rRNAs                     :: 2 (5S)
            tRNAs                             :: 46
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 173
            CDSs (without protein)            :: 173
            Pseudo Genes (ambiguous residues) :: 0 of 173
            Pseudo Genes (frameshifted)       :: 71 of 173
            Pseudo Genes (incomplete)         :: 93 of 173
            Pseudo Genes (internal stop)      :: 58 of 173
            Pseudo Genes (multiple problems)  :: 41 of 173
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 15:29:07
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 13739
            Orig. end                         :: 29344
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            FDFR01000002.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..15605
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RiPP-like"
                     /region_number="1"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..15605
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..15605
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[5000:10605]"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..10605
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     gene            complement(334..663)
                     /locus_tag="A1O50_RS02305"
                     /old_locus_tag="ERS409084_00446"
     CDS             complement(334..663)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001864062.1"
                     /locus_tag="A1O50_RS02305"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS409084_00446"
                     /product="hypothetical protein"
                     /protein_id="WP_047499345.1"
                     /transl_table=11
                     /translation="MTDTDPIKRAQTLITDLNKAYQACKQASADDVRFQEQLNSILGFL
                     AKAETVDNRFLIELEKFYQTSSLLMGLSALDPDAPTRAAWRAYDRFHFDQVKTKLILNE
                     NQRAN"
     misc_feature    complement(707..725)
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: weak, score: 23.85"
                     /tool="antismash"
     misc_feature    801..814
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: medium, score: 22.71"
                     /tool="antismash"
     gene            939..1277
                     /locus_tag="A1O50_RS02310"
                     /old_locus_tag="ERS409084_00447"
     CDS             939..1277
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000682119.1"
                     /locus_tag="A1O50_RS02310"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS409084_00447"
                     /product="LytTR family DNA-binding domain-containing
                     protein"
                     /protein_id="WP_000682137.1"
                     /transl_table=11
                     /translation="MKHMIIQTQKTVYKVNVDDVYYIQTHPTKAHTVQIVTEEASFNMV
                     QNLSNLENQYGETLMRCHRNCLVNLDKVKSIDFQERILFLGEEGQYAVKYARRRYREIR
                     QKWLKEGE"
     gene            1282..2019
                     /locus_tag="A1O50_RS02315"
                     /old_locus_tag="ERS409084_00448"
     CDS             1282..2019
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001219153.1"
                     /locus_tag="A1O50_RS02315"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS409084_00448"
                     /product="LytTR family DNA-binding domain-containing
                     protein"
                     /protein_id="WP_001219137.1"
                     /transl_table=11
                     /translation="MRIFVLEDDFSQQTRIETTIEKLLKEHHITLSSFEVFGKPDQLLA
                     EVHEKGAHQLFFLDIEIRNEEMKGLEVARKIRDRDPYALIVFVTTHSEFMPLSFRYQVS
                     ALDYIDKALSAEEFESRIETALLYANGQDSKSLAEDCFYFKSKFAQFQYPFKEVYYLET
                     STRPHRVILYTKTDRLEFTASLEEVLKQEPRLLQCHRSFLINPANVVHLDKKEKLLFFP
                     NGGSCLIARYKVREVSEAINNLH"
     gene            2048..3373
                     /locus_tag="A1O50_RS02320"
                     /old_locus_tag="ERS409084_00449"
     CDS             2048..3373
                     /EC_number="2.7.13.3"
                     /GO_function="GO:0000155 - phosphorelay sensor kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0004673 - protein histidine kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0007165 - signal transduction [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001099894.1"
                     /locus_tag="A1O50_RS02320"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS409084_00449"
                     /product="sensor histidine kinase"
                     /protein_id="WP_142992147.1"
                     /transl_table=11
                     /translation="MLLYTLVTHGLKIVIFFKVDGISLTFERIFKAFLFKILLAVVFGM
                     LGYMVGNTYLSYFMEPLYGIGLSFLLLRELPKKLLLFYGLFPMILVNLFYRGVSYFVLP
                     FLGQGQVYDDYSFIWLCIIIFNFFISLAFLKWLDYDFTSLRKGILDKDFQKSLTQINWI
                     MGAYYLVIQNLSYFEYEQGIQSTTVRHLILVFYLLFFMGIIKKLDTYLKDKLHERLNQE
                     QDLRYREMERYSRHIEELYKEVRSFRHDYTNLLTSLRLGIEEEDMEQIKEIYDSVLKDS
                     SEKLQDNKYDLGRLVNIRDKALKSLLAGKFLKARDKNIVFNVEVPEEIQVEGMSLLDFL
                     TVVSILCDNAIEASVEACQPHVSIAFLKNGAQETFIIENSIKEEGIDISEIFSFGASSK
                     GEERGVGLYTVMKIVESHPNTSLNTTCQDHVFRQVLTVIHIE"
     gene            complement(3417..3572)
                     /gene="blpC"
                     /locus_tag="A1O50_RS02325"
                     /old_locus_tag="ERS409084_00450"
     CDS             complement(3417..3572)
                     /codon_start=1
                     /gene="blpC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) L_biotic_A"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000358812.1"
                     /locus_tag="A1O50_RS02325"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS409084_00450"
                     /product="quorum-sensing system pheromone BlpC"
                     /protein_id="WP_000358811.1"
                     /sec_met_domain="L_biotic_A (E-value: 1.1e-06, bitscore:
                     22.9, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDKKQNLTSFQELTTTELNQIIGGGWWEDFLYRFNIIEQKNTKGF
                     HQPIQL"
     gene            complement(3629..4990)
                     /locus_tag="A1O50_RS02330"
                     /old_locus_tag="ERS409084_00451"
     CDS             complement(3629..4990)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001069090.1"
                     /locus_tag="A1O50_RS02330"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS409084_00451"
                     /product="bacteriocin secretion accessory protein"
                     /protein_id="WP_054407076.1"
                     /transl_table=11
                     /translation="MNPNLFRSVEFYQRRYHNYATVLIIPLSLLFTFILIFSLVATKEI
                     TVTSQGEITPTSVIASIQSTSDNPILANHLVANQVVEKGDLLIKYSETMEESQKTALET
                     QLQRLEKQKEGLGILKQSLEKATDLFSSEDEFGYHNTFMNFTKQSHDIELGISKTNTEV
                     SNQANLTNSSSSAIEQEITKVQQQIGEYQELRDAIVNKRARLPTGNPHQSILNRYLIAS
                     QEQTQGTAEEPFLSQINQSIAGLESSIASLKIQQAGIGSVATYDNSLATKIEVLRTQFL
                     QTASQQQLTVENQLTELKVQLDQATQRLGNNTLTAPSKGIVHLNSEFEGKNRIPTGTEI
                     AQIFPVITDTREVLITYYVSSDYLPLLDKGQTVRLKLEKIGNHGTTIIGQLQTIDQTPT
                     RTEQGNLFKLTALAKLSNEDSKLIQYGLQGRVTSVTTKKTYFDYFKDKILTHSD"
     gene            complement(5001..6677)
                     /locus_tag="A1O50_RS02335"
                     /old_locus_tag="ERS409084_00452"
     CDS             complement(5001..6677)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_component="GO:0043190 - ATP-binding cassette (ABC)
                     transporter complex [Evidence IEA]"
                     /GO_function="GO:0008234 - cysteine-type peptidase activity
                     [Evidence IEA]"
                     /GO_function="GO:0043214 - ABC-type bacteriocin transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0043213 - bacteriocin transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: TIGR01193"
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR01193.1"
                     /locus_tag="A1O50_RS02335"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS409084_00452"
                     /product="peptide cleavage/export ABC transporter"
                     /protein_id="WP_306423907.1"
                     /sec_met_domain="TIGR01193 (E-value: 9.8e-265, bitscore:
                     874.8, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIFKQKSLIAYIVLSSLLVTIINIGGSYYLQGILDEYIPNQMKST
                     LGIISVGLVITYILQQVMSFSRDYLLTVLSQRLSIDVILSYIRHIFELPMSFFATRRTG
                     EIISRFTDANSIIDALASTILSLFLDVSILILVGGVLLAQNPNLFLLSLLSIPIYMFII
                     FSFMKPFEKMNHDVMQSNSMVSSAIIEDINGIETIKSLTSEENRYQNIDSEFVDYLEKS
                     FKLSKYSILQTSLKQGTKLVLNILILWFGAQLVMSSKISIGQLITFNTLFSYFTTPMEN
                     IINLQTKLQSAKVANNRLNEVYLVESEFQVQENPVHSHFLMGDIEFDDLSYKYGFGRDT
                     LTDINLTIKQGDKVSLVGVSGSGKTTLAKMIVNFFEPYKGHISINHQDIKNIDKKVLRR
                     HINYLPQQAYIFNGSILENLTLGGNHMISQEDILRACELAEIRQDIERMPMGYQTQLSD
                     GAGLSGGQKQRIALARALLTKAPVLILDEATSGLDVLTEKKVIDNLMSLTDKTILFVAH
                     RLSIAERTNRVIVLDQGKIIEVGSHQELMQAQGFYHHLFNK"
     gene            complement(6571..7158)
                     /locus_tag="A1O50_RS13800"
                     /old_locus_tag="ERS409084_00453"
     CDS             complement(6571..7158)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001855030.1"
                     /locus_tag="A1O50_RS13800"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS409084_00453"
                     /product="cysteine peptidase family C39 domain-containing
                     protein"
                     /protein_id="WP_054370532.1"
                     /sec_met_domain="Peptidase_C39 (E-value: 9.5e-42, bitscore:
                     136.4, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSYKRTFVPQIDARDCSVAALASIAKFYGSDFSLAHLRELAKTN
                     KEGTTALGIVKAADEMGFETRPVQADKTLFDMSDVPYPFIVHVNKEGKLQHYYVVYQTK
                     KDYLIIGDPDPSVKITKMSKERFFYEWTGVAIFLAPKPSYQPHKDKKNGLLSKLPSSDF
                     QTKISHCLHCSLKLISHYYQYRWFLLSPRNLG"
     gene            7448..7651
                     /locus_tag="A1O50_RS02345"
                     /old_locus_tag="ERS409084_00454"
     CDS             7448..7651
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Bacteriocin_IIc"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001093272.1"
                     /locus_tag="A1O50_RS02345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS409084_00454"
                     /product="bacteriocin class II family protein"
                     /protein_id="WP_001093272.1"
                     /sec_met_domain="Bacteriocin_IIc (E-value: 7e-10, bitscore:
                     33.6, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNTKMMSQFSVMDNEMLDRIEGGIFGVDDALFWAGLGYVAGSIVD
                     TAIDDFTNQCRKNPHQWFCVRV"
     misc_feature    7722..7738
                     /note="TFBS match to NuR, Nickel-responsive regulator,
                     confidence: weak, score: 22.78"
                     /tool="antismash"
     gene            7969..8172
                     /locus_tag="A1O50_RS02350"
                     /old_locus_tag="ERS409084_00455"
     CDS             7969..8172
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000411016.1"
                     /locus_tag="A1O50_RS02350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS409084_00455"
                     /product="hypothetical protein"
                     /protein_id="WP_000411016.1"
                     /transl_table=11
                     /translation="MEKIDYITLNEVELETISGGDDCFIGDIGCIGWGLLKSIGGMIKP
                     APYVPPVCIPKSSWNPAPPVPC"
     gene            9175..>9979
                     /locus_tag="A1O50_RS11910"
                     /pseudo=""
     CDS             9175..>9979
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001105201.1"
                     /locus_tag="A1O50_RS11910"
                     /note="programmed frameshift; internal stop; incomplete;
                     partial in the middle of a contig; missing C-terminus;
                     Derived by automated computational analysis using gene
                     prediction method: Protein Homology."
                     /product="IS5 family transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MNYEGSKQLTDARFKCLVGVQCTTFEEMLAVLKTAYQLKHAKGGR
                     KPKLSLEDLLMGTLQYV"
     gene            10132..10386
                     /gene="blpM"
                     /locus_tag="A1O50_RS02365"
                     /old_locus_tag="ERS409084_00458"
     CDS             10132..10386
                     /codon_start=1
                     /gene="blpM"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Bacteriocin_IIc"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000379879.1"
                     /locus_tag="A1O50_RS02365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS409084_00458"
                     /product="two-peptide bacteriocin subunit BlpM"
                     /protein_id="WP_000379877.1"
                     /sec_met_domain="Bacteriocin_IIc (E-value: 2.1e-19,
                     bitscore: 64.2, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDTKIMEQFHEMDITMLSSIEGGKNNWQTNVLEGGGAAFGGWGLG
                     TAICAASGVGAPFMGACGYIGAKFGVALWAGVTGATGGF"
     gene            10402..10605
                     /gene="blpN"
                     /locus_tag="A1O50_RS02370"
                     /old_locus_tag="ERS409084_00459"
     CDS             10402..10605
                     /codon_start=1
                     /gene="blpN"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Bacteriocin_IIc"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001099492.1"
                     /locus_tag="A1O50_RS02370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS409084_00459"
                     /product="two-peptide bacteriocin subunit BlpN"
                     /protein_id="WP_001099492.1"
                     /sec_met_domain="Bacteriocin_IIc (E-value: 5.7e-13,
                     bitscore: 43.5, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNTYCNINETMLSEVYGGNSGGAAVVAALGCAAGGVKYGRLLGPW
                     GAAIGGIGGAVVCGYLAYTATS"
     gene            10849..11082
                     /locus_tag="A1O50_RS02375"
                     /old_locus_tag="ERS409084_00460"
     CDS             10849..11082
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000379963.1"
                     /locus_tag="A1O50_RS02375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS409084_00460"
                     /product="hypothetical protein"
                     /protein_id="WP_050150746.1"
                     /transl_table=11
                     /translation="MDTKMMSQFSVMDNEMLVRTEDGDVSDIYRGYANQRSPFASYPSI
                     LKNSGPFPVSGYCPRGYRDLGYIGAGFHLCGI"
     gene            11114..11803
                     /locus_tag="A1O50_RS02380"
                     /old_locus_tag="ERS409084_00461"
     CDS             11114..11803
                     /EC_number="3.4.-.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abi"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000760553.1"
                     /locus_tag="A1O50_RS02380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS409084_00461"
                     /product="CPBP family intramembrane glutamic endopeptidase"
                     /protein_id="WP_000760527.1"
                     /sec_met_domain="Abi (E-value: 4.3e-11, bitscore: 37.6,
                     seeds: 823, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKYQLLFKISAVFSYLFFVFGLSQLTLIVQNYWQFSSQIGNLFW
                     IQNILSLLFIGVMIVVLVKTGHGYLFRIPRKKWLWYSILTVLVVVFQISFNVQTAKHVQ
                     STAEGWAVLIGYSGTNFAELGIYIALFFLVPLMEELIYRGLLQHAFFKHSRFGLDLLLP
                     SILFALPHFSSLPSLLDIFVFATVGIIFAGLTRYTKSIYPSYAVHVINNIVATFPFLLT
                     FLHRVLG"
     gene            11845..>11928
                     /gene="blpZ"
                     /locus_tag="A1O50_RS13805"
     CDS             11845..>11928
                     /codon_start=1
                     /gene="blpZ"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000276505.1"
                     /locus_tag="A1O50_RS13805"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="immunity protein BlpZ"
                     /protein_id="WP_321572416.1"
                     /transl_table=11
                     /translation="MYKHLFFLDSKTLDRLTPYILVLASDTI"
     assembly_gap    11929..12241
                     /estimated_length=313
                     /gap_type="unknown"
                     /linkage_evidence="unspecified"
     gene            12285..12896
                     /locus_tag="A1O50_RS02385"
                     /old_locus_tag="ERS409084_00462"
     CDS             12285..12896
                     /EC_number="3.4.-.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abi"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000394041.1"
                     /locus_tag="A1O50_RS02385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS409084_00462"
                     /product="CPBP family intramembrane glutamic endopeptidase"
                     /protein_id="WP_000394045.1"
                     /sec_met_domain="Abi (E-value: 1.2e-20, bitscore: 68.2,
                     seeds: 823, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEFFDKFHALCFGFLVLIIVITVPYTINHGGFFQNESALILVSLL
                     VTSLSVAYARKFEMISFGMLSKKQLLLFIAIFLLSVLETLVYIHFFAVSSGSGVQHLAE
                     VSRGISLSLILTTSVFGPIQEELIFRGLLQGAVFDNSWLGLVLTSSLFSFMHGPSNVPS
                     FIFYLLGGLLLGFAYKKSQNLWVSTLVHMLYNSWPLLYYL"
     gene            13057..13851
                     /gene="ccrZ"
                     /locus_tag="A1O50_RS02390"
                     /old_locus_tag="ERS409084_00463"
     CDS             13057..13851
                     /EC_number="2.7.1.15"
                     /EC_number="2.7.1.229"
                     /GO_function="GO:0004747 - ribokinase activity [Evidence
                     IEA]"
                     /GO_function="GO:0016773 - phosphotransferase activity,
                     alcohol group as acceptor [Evidence IEA]"
                     /GO_function="GO:0019200 - carbohydrate kinase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006270 - DNA replication initiation
                     [Evidence IEA]"
                     /GO_process="GO:0051726 - regulation of cell cycle
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="ccrZ"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) APH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000363010.1"
                     /locus_tag="A1O50_RS02390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS409084_00463"
                     /product="cell cycle regulator CcrZ"
                     /protein_id="WP_000363002.1"
                     /sec_met_domain="APH (E-value: 7e-19, bitscore: 63.1,
                     seeds: 156, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDLGDNELTLTPIPGKSGKAYMGSYPDGKRIFVKMNTSPILPGLA
                     REQIAPQLLWSRRLADGRDMCAQEWLTGKILTPYDMNRKQIVNILTRLHRSRPLMTQLS
                     RLGYAMETPVDLLQSWQETAPDALRKNHFISEVMADLRQTIPGFREDHATIVHGDVRHS
                     NWIETDSGLIYLVDWDSVRLTDRMFDVAHMLCHYISEHQWKEWLTYYGYKYNQTVLSKL
                     YWYGQLSYLSQISKYYMNQDLENVNREIHGLRHFRDKYGKRR"
     gene            13848..14483
                     /gene="trmB"
                     /locus_tag="A1O50_RS02395"
                     /old_locus_tag="ERS409084_00464"
     CDS             13848..14483
                     /EC_number="2.1.1.33"
                     /GO_function="GO:0008176 - tRNA
                     (guanine(46)-N7)-methyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0006400 - tRNA modification [Evidence IEA]"
                     /codon_start=1
                     /gene="trmB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001266107.1"
                     /locus_tag="A1O50_RS02395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS409084_00464"
                     /product="tRNA (guanosine(46)-N7)-methyltransferase TrmB"
                     /protein_id="WP_001266083.1"
                     /transl_table=11
                     /translation="MRVRNRKGATELLEANPQYVVLNPLEAKAKWRDLFGNDNPIHVEV
                     GSGKGAFVSGMAKQNPDINYIGIDIQKSVLSYALDKVLEVGVPNIKLLWVDGSDLTDYF
                     EDGEIDRLYLNFSDPWPKKRHEKRRLTYKTFLDTFKRILPENGEIHFKTDNRGLFEYSL
                     VSFSQYGMKLNGVWLDLHASDFEGNVMTEYEQKFSNKGQVIYRVEAEF"
     gene            14609..15088
                     /gene="rimP"
                     /locus_tag="A1O50_RS02400"
                     /old_locus_tag="ERS409084_00465"
     CDS             14609..15088
                     /GO_process="GO:0042274 - ribosomal small subunit
                     biogenesis [Evidence IEA]"
                     /codon_start=1
                     /gene="rimP"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000338698.1"
                     /locus_tag="A1O50_RS02400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS409084_00465"
                     /product="ribosome maturation factor RimP"
                     /protein_id="WP_001808691.1"
                     /transl_table=11
                     /translation="MDAIATIVELVREVVEPVIEAPFELVDIEYGKIGSDMILSIFVDK
                     PEGITLNDTADLTEIISPVLDTIKPDPFPEQYFLEITSPGLERPLKTKDAVAGAVGKYI
                     HVGLYQAIDKQKVFEGTLLAFEEDELTMEYMDKTRKKTVQIPYSLVSKARLAVKL"
     misc_feature    complement(15121..15136)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 22.45"
                     /tool="antismash"
ORIGIN
        1 acaggaggta gttcgaggat tgaccagttt tgttttactt gtggaattag ttgttggctt
       61 gattaccttc caagaaaaac tggcccttct agccttacta ggagctggtt tggttttact
      121 agtcttgtat ttgccttatc aggtaaaacg tcagatgcag gactaacatt gctgatacga
      181 cactaaaaaa gaagttgagt tcagtctgtc tcaacttctt ttttgttact acaggataat
      241 ggttggtccg tagagactta tactcttcga aaatctcttc aaaccacgtc agcgtcgcct
      301 taccgtactc aagtacagct tgcggctagc ttcctagttt gctctttgat tttcattgag
      361 tattaacttg gttttgactt ggtcaaagtg gaagcggtca taggcccgcc aagcggcgcg
      421 agttggagca tctggatcaa gagcgctgag tcccatgaga agactggaag tctggtaaaa
      481 tttttctagt tcaatcaaga atcgattatc cactgtttca gccttggcta gaaaaccaag
      541 aatagagttt aattgctcct gaaagcggac gtcgtcagcg cttgcctgtt tgcatgcttg
      601 gtaggctttg tttaagtcag taatcaaagt ctgagctctt ttgatggggt ctgtatctgt
      661 catgggaatg cctcctttaa tctgggtgcc agtcttactt ctggcaactg tgttttgata
      721 ctgttagttt atcactttta attctttttt ttattcaaat ctttaattgt cattgaaatg
      781 tcttgaattg cgctgagtga attttatgat aaaatagtgg taagctcatc atgatattgt
      841 agaaaaataa ttcttttagg agctttcaaa gactgtttag gattgggtgt gcttgggcta
      901 gaacttttct gttattcttt tcttaggagg agaatccaat gaaacatatg attattcaga
      961 cacagaaaac agtctataaa gtaaacgtcg acgatgtcta ctatatccaa acacatccaa
     1021 ctaaagccca taccgtacag attgttacag aagaggctag ttttaatatg gttcaaaatt
     1081 taagtaatct tgagaaccaa tatggggaaa ccttgatgag atgtcatcga aattgtttgg
     1141 tcaatcttga taaagtaaaa tcgattgatt ttcaagaaag aatccttttt cttggagaag
     1201 aaggtcaata cgctgtcaag tatgccagac gtcgctatag agaaattcgt caaaaatggt
     1261 tgaaagaagg agagtaagaa gatgagaata tttgttttag aagatgattt ttcccaacag
     1321 actagaattg aaacgacgat tgagaaactc ttgaaggaac atcatatcac tctgagttct
     1381 tttgaagttt ttggtaagcc agatcaattg ctggcagagg tgcatgagaa gggggcccat
     1441 cagctattct ttttggatat tgagattcga aatgaggaga tgaagggtct ggaagtggct
     1501 agaaagattc gggatcggga tccgtatgcc ctgattgtct ttgtgacgac tcactcggag
     1561 tttatgcccc tgtcctttcg ctaccaagtg tctgctctgg actatattga taaggccctt
     1621 tcggcagagg agtttgaatc tcgtatcgag acagccctcc tctatgccaa tggtcaagac
     1681 agtaaaagtc tagcggaaga ttgcttttac tttaaatcaa aatttgctca attccagtat
     1741 ccttttaaag aggtttacta tctcgaaacg tccacaagac cccatcgtgt tattctctat
     1801 accaagacag acaggctgga atttacagcg agtctagagg aggttctcaa gcaggagcct
     1861 cgtctcttgc agtgccatcg ctcttttctc atcaatcctg ccaatgtggt gcatttagat
     1921 aagaaagaaa aactgctttt ctttcccaat ggtggaagtt gtctaatcgc gcgttataag
     1981 gtcagggaag tgtctgaggc tattaataac ttacactgag ctaggatagt ttatgaatgt
     2041 tgcttagata ttgttgtata cacttgttac tcacggatta aaaattgtca tattctttaa
     2101 ggtagatgga attagtctca cttttgagag gatttttaag gcctttcttt ttaagatact
     2161 gttggccgtt gtttttggaa tgcttggcta tatggtagga aatacttatc tatcttattt
     2221 tatggaaccc ttgtacggca taggcttatc tttcttattg ttaagagaac ttcctaaaaa
     2281 actccttctc ttttatggtc tctttccaat gatattagtg aatctctttt atagaggtgt
     2341 ttcctatttt gtgcttccat ttttgggaca agggcaagta tatgatgact actcatttat
     2401 ttggttatgt ataataattt tcaatttctt catttctcta gcttttttga aatggttgga
     2461 ctatgatttc actagcttga gaaaggggat tctcgataaa gattttcaaa agtccctgac
     2521 tcagattaac tggataatgg gggcttacta tttggtgata caaaatctgt cttactttga
     2581 atatgaacag gggattcaat caacgactgt tcgccatctc atcctagtct tttacctgct
     2641 cttttttatg gggattatca agaaattgga tacctatttg aaggacaaac tccatgagag
     2701 actgaaccaa gagcaggact tgcgctacag agagatggag cggtatagtc ggcatataga
     2761 ggagctttat aaggaagtac ggagttttcg ccatgactac accaacctct tgactagctt
     2821 acgtctgggc attgaagagg aggatatgga gcagataaaa gagatctacg actcggtctt
     2881 aaaggattct agtgaaaaat tgcaggacaa taaatatgac cttggtcgat tggtgaatat
     2941 tcgtgataaa gccctcaaaa gtctcctagc agggaaattt ctaaaagcta gagataagaa
     3001 cattgtcttt aatgtcgaag ttccagagga gattcaggta gaggggatga gtctacttga
     3061 ttttctaacc gttgtgtcta tcctttgtga caacgctatt gaagctagtg tagaagcctg
     3121 tcaacctcat gtttcaattg cctttttaaa aaatggagca caggagacct ttatcattga
     3181 aaattccatc aaagaagagg gaatcgatat ttctgaaatc ttctcctttg gagcaagttc
     3241 taaaggggag gagagaggag ttggtctcta taccgttatg aaaattgtgg aaagtcatcc
     3301 caataccagt ctcaatacca cctgccaaga tcacgttttt cgtcaggtac ttactgtaat
     3361 acatatagaa tgaagaaaaa ataagaccga gagtgcgttc tcttggtctt gtttttttat
     3421 agttgtattg gctgatgaaa tccttttgta tttttttgtt caattatatt aaatctatat
     3481 aagaaatctt cccaccatcc tccacctata atttggttga gttcggtagt tgttagttct
     3541 tgaaatgaag ttaggttttg tttcttatcc atgttatgat tctccttttt gataagataa
     3601 taaatagtta tagagtgtta tctgaaaatt aatcagaatg ggttaaaatt ttatctttga
     3661 aataatcaaa atatgttttc tttgtagtta cactagtgac gcgaccttgt aagccatatt
     3721 ggatgagttt actatcctcg ttagatagtt ttgcaagagc ggttaattta aagagattac
     3781 cttgctctgt tctggtagga gtttgatcaa ttgtctgaag ttggccgatg atggtggtgc
     3841 cgtgatttcc aatcttctcc agttttaatc ttacagtttg tcctttatct agtagaggta
     3901 gatagtcaga agatacgtag taagtgatta gtacttctct tgtatctgtg atgacaggga
     3961 atatttgagc aatttctgta ccagttggaa ttctattttt accttcaaat tcgctgttca
     4021 gatgaacgat acctttactt ggagcggtta aggtattgtt tcctaagcgc tgcgttgctt
     4081 gatctagttg tacttttaat tctgttaatt gattctccac ggttagttgt tgctgtgagg
     4141 ctgtttgtaa aaactgagtg cggagtactt caattttggt tgctaaacta ttatcataag
     4201 ttgctacact tccgatacca gcttgctgaa ttttgaggct tgcgatagat gattccagac
     4261 ctgcaatact ttgattaatt tgagataaaa atggctcctc tgccgttcct tgtgtttgtt
     4321 cttgagaggc tataagataa cgatttaaaa ttgactggtg cggattgcca gttggtaagc
     4381 gagctctttt atttacgata gcatctctca gctcttgata ttctccaatt tgttgttgaa
     4441 cttttgtaat ttcttgttcg atggctgatg aactgctatt ggtaagatta gcttgatttg
     4501 aaacttcagt gttagtcttt gagataccca gttcaatatc atgggattgt ttagtaaaat
     4561 tcataaaagt attatggtag ccaaactcat cctcgctaga aaaaagatca gtcgcttttt
     4621 ctaagctttg tttcaagatt ccaagtcctt ctttttgctt ctcaagtctt tgtaattgag
     4681 tttctaaggc agttttctga ctctcttcca ttgtttcaga gtatttgatg agtaagtcac
     4741 ctttctcaac tacttgattt gccactaaat gattagcaag gataggatta tcactggtcg
     4801 actgaataga tgcaatgaca cttgtagggg tgatttcccc ttgggaagta acagtaattt
     4861 cttttgtggc aacaagggag aaaatcaaga tgaaagtaaa taataatgaa agaggtatga
     4921 ttaatactgt cgcatagtta tggtaacgtc tctgataaaa ctcgacgctt ctaaaaagat
     4981 taggattcat gacattctcc ttatttattg aacagatgat ggtagaagcc ttgcgcctgc
     5041 attaactctt ggtgactacc aacttcaatg attttcccct ggtcaagaac aatgacacgg
     5101 ttagttcgtt cggctatact gagacgatgg gctacaaaga gaatggtttt atcagttagg
     5161 gacataagat tatctataac ttttttctca gtcaagacat caagaccgct agtagcttcg
     5221 tctagtatta aaacaggagc tttagttaaa agagcacgag cgagggctat tcgttgcttc
     5281 tgtcctcctg atagaccagc tccatcagag agctgagttt gatagcccat aggcattctt
     5341 tcaatgtctt gacggatttc agctaattca caagctctta gaatatcttc ttggctaatc
     5401 atatgattac cgcccaaggt taaattttcc aagatagagc cattaaagat ataggcttgt
     5461 tggggtaggt aattaatatg acggcgcaag acttttttat caatgttttt aatatcctga
     5521 tgattgatgg aaatatgccc tttgtagggt tcaaagaaat tgacaatcat tttggctaaa
     5581 gttgttttac cagaaccact aactccaact aggctaacct tatctccttg tttaatcgtg
     5641 agattaatat ctgttaaggt atctcgtcca aaaccatact tataagaaag gtcatcaaat
     5701 tcaatatcgc ccatcaaaaa atgtgaatgg acagggtttt cttgaacttg aaattcagat
     5761 tcgactagat agacttcgtt caaacggtta ttagcgacct tcgcagattg gagtttggtt
     5821 tggaggttga taatattttc cataggagtt gtaaagtaag aaaaaagtgt gttaaaggta
     5881 atcagctgac cgatagaaat tttactcgac atgactaatt gagcgccaaa ccataggata
     5941 aggatattca gaactaattt tgttccctgc tttaaactcg tttgtaaaat agaatattta
     6001 ctgagcttaa aggatttttc caaataatct acaaattcgc tgtctatatt ttgatagcga
     6061 ttttcttcac tcgtgagcga ctttatagtt tcaatcccgt tgatatcttc gataatggca
     6121 gagctaacca tagaattact ttgcatgaca tcatggttca ttttttcaaa aggtttcata
     6181 aaagaaaaga tgatgaacat gtatatagga atggaaagaa gagaaaggag gaagagatta
     6241 gggttttgtg ccagtaagac gccccctaca agaatcagaa tagaaacatc cagaaaaaga
     6301 gaaagaatgg tagaagccaa ggcatctata atagagttag catctgtgaa ccgtgaaatg
     6361 atttctcctg tacgacgtgt cgcaaagaaa gacatgggaa gttcaaaaat atggcgaata
     6421 taggataaaa tcacatcaat gcttaatctc tggctcagaa cggttaggag ataatctctg
     6481 gagaagctca tgacttgttg gaggatatag gtgataacca gaccaactga gatgattcct
     6541 aaagttgatt tcatctgatt tggaatgtat tcatccaaga ttccttggag atagtaagaa
     6601 ccacctatat tgataatagt gactaataag cttgagagaa caatgtaagc aatgagagat
     6661 ttttgtttga aaatcagagg aaggaagctt gcttagtaga ccattctttt tatctttatg
     6721 gggttgatag ctgggtttgg gagctagaaa aatagctact ccagtccatt catagaaaaa
     6781 gcgttctttt gacattttag tgatttttac agaagggtca ggatcaccaa taatcagata
     6841 gtctttcttt gtttgataga caacatagta atgttggagt tttccttctt tgttaacgtg
     6901 aacgataaat ggatagggga catcactcat gtcaaagagc gttttatctg cttgaacagg
     6961 tcttgtttca aagcccattt catcagcggc ttttacaatg ccaagagcag tcgtcccttc
     7021 tttattggtc tttgcaagtt ctctcaagtg agctagagaa aaatctgaac catagaattt
     7081 agcaatcgag gctaaggcag cgacactaca gtctctcgca tctatttgag gaacaaatgt
     7141 acgtttataa gaagtcattg gcaattcttt tcatatagtg gataggtcta ttatgtcata
     7201 aaactaagtt catattttat gaaatcttga atagtcatta aaacttcctg aatggtaaaa
     7261 aagtgattag aaattatttt ttttaaacat ttagaggtgg cttgaaatag aggtggcttg
     7321 aaataaaaaa gctaattcaa gacgtttcga tgacaattca agatctggat gaaaaatttt
     7381 aaaaaacgat gatatactaa acttatcaaa gttacaacaa gacaaaaata aaaaaggagt
     7441 atttgtcatg aatacaaaaa tgatgtcaca attttctgtt atggataatg aaatgcttga
     7501 taggatagag ggaggaatat ttggagttga cgatgctttg ttttgggcag ggttaggcta
     7561 tgttgcaggt agcattgttg atacagcaat tgatgatttt acgaatcaat gccggaaaaa
     7621 tcctcatcag tggttctgtg ttcgtgtata gatatagtag tgttgtattg tataagaatt
     7681 tatataactt aatgacctat gcagtgatag aaactattct tttgcaaacg agtcgcttat
     7741 tctgttataa gtttacgtgc tcctagtcac agttcttgtg cttgatagaa agaatgacac
     7801 ctataaaaat gcgagatatt ggctatatca ctcacttatt cacctccccg tgatttgtag
     7861 tagtgatagg ttttctcact attattataa acattataaa ataaagagta caacactttt
     7921 tcattctgtg ttgtgccttg agtaaaacga aaggaatgaa ttataacaat ggaaaaaatt
     7981 gattatatta ctttgaatga agtagaatta gagacgatta gtggtggaga tgactgtttt
     8041 attggagata tcggatgtat cggctggggg cttttgaaga gtatcggagg gatgataaaa
     8101 cctgctccat atgttcctcc agtatgcatt ccaaaaagtt cgtggaatcc tgcacctcca
     8161 gttccatgtt aaaaagttat tgtaaactta tataaaaaat gaataatcga cttgttcgct
     8221 attttgttga atcttcgtaa ctataatata caggtgttgt tcaggattat tttagcttat
     8281 tgcaagagtc gaaaactaga aactaatggc tggttggaac gttaaaaatt cactttctaa
     8341 tcagctaata ctgcttcaaa taatttctga acaagtctaa taaataaaac gaataagata
     8401 gattattaac acagtcttgt tcgttttttc tcatatatta tttaattaat aatattataa
     8461 aattggaaag cagtagggat gggaagtact accacagatt tattattaat tttatcagta
     8521 ttgtttgaaa tccaaaaaaa gtatgttaag ctatatttat ttggttcttt agtttgattg
     8581 ttgttgagta taactatttt tgtatagatg aaaatcttgt tattgttcaa gatgttttga
     8641 tgaccattca tgatttgagt aatccaaggt caaaatgagt gctatactag cagtgtaaag
     8701 attcttgttc aactaagata aatcacacat ttaggaggaa attttatgaa gaaaaaaata
     8761 cttatcattt tcatcttgta tctaatcatg tccatctttc tttatccgct tagggaaagt
     8821 atttggtatc agctatttta taccatagcc tatgtgattg cagttatgat ctattttgct
     8881 ttaactaaaa agaaaggagc aaagaaatga aaacttttct tgctaaaaaa cggaacatct
     8941 tcctttcgtt tgggggttga agtattataa aaagtagaag ttaatgaagt ataaaagggt
     9001 aagtgttttt gcaatactta cccttttata atagattccc tgcgaaacaa aatatggtat
     9061 agtatagtag attgaaacta gaatagtacg cctctacttc taaaacattg ttagaaatcg
     9121 atttgactgt cctgattgat ttatcctgtt cttatttcat tttactatag ttctatgaat
     9181 tatgaaggaa gtaaacaact aactgatgca cgatttaaat gtcttgttgg tgttcaatgc
     9241 acgacttttg aagagatgtt agctgtatta aaaacagctt atcaacttaa acacgcaaaa
     9301 ggtggacgaa aacctaaatt aagcctagaa gaccttctta tgggcactct tcaatatgtg
     9361 tgagaatacc gcacttatga agaaattgcg gctgattttg gtattcacga aagcaactta
     9421 ctccgtcgga gccaatgggt tgaagtaact cttgttcaaa gtggtgttac gatttcaaga
     9481 actcctctca gctctgagga cacggtaatg attattgatg cgacggaagt ataaatcaat
     9541 cgccctaaaa aaagaattag cgaattattc tggtaaaaag aaatgccacg ctatgaaggc
     9601 tcaagcgatt gtcacaagtc aagggagaat tgtttctttg gatatcactg tgaactattg
     9661 tcatgatatg aagttgttca aaatgagttg cagaaatatc ggacaagctg gtaaaatctt
     9721 ggctgacagt ggttatcaag ggctcatgaa gatatatcct caagcacaaa ctccacgtaa
     9781 agccagcaaa ctcaaaccgc taacagctga agataaagcc tgtaaccatg cactatctaa
     9841 ggatagaagc aaggttgaga acatccttgc caaagtaaaa acgtttaaaa tgttttcaac
     9901 aacctatcga aatcatcgta aacgcttcgg attacgaatg aatttgattg ctggtattat
     9961 caatcatgaa ctaggatttt ggtttcgcaa gaagtctaat gtaatttttg caattcaaga
    10021 cgtttcgatg actattcaag atctggatga aaaattttaa aaaacgatga tatactaaac
    10081 ttgtcaaagt tacaacaaga caaaaattaa aaataaaaaa gagtatttgt catggataca
    10141 aaaattatgg aacaatttca tgaaatggat ataactatgt tatctagtat tgaaggaggc
    10201 aagaataatt ggcaaactaa tgtcttagaa ggtggtggtg ctgcttttgg tggctggggg
    10261 ttagggacag ctatttgtgc tgcgagtggt gttggagcgc catttatggg agcatgtgga
    10321 tacataggag ctaaatttgg tgtggctctt tgggcaggag taacaggggc aacgggtgga
    10381 ttttaacaaa aggagacttg tatgaatact tattgtaata taaatgaaac aatgctgagt
    10441 gaggtttatg gaggtaattc cggaggagca gctgtagttg ctgctttagg ttgtgcagcg
    10501 ggtggagtga aatatgggag acttctagga ccatggggcg ctgcaatagg aggaattgga
    10561 ggagcagtgg tttgtggata tttagcctat accgctacat cataaaaatg aaagctaaat
    10621 tttatgaagg ctatattctt tattattctc ttcgcttttc aaacctatct tatttatcta
    10681 tccataagta tctccgataa aaaacaaaag actattgaat taacatcatt gaattgtttt
    10741 gtcatattat ttctaatcta tgataaatta atttttctct ttattgctta tgtttttttg
    10801 ataattttta tattaaactt gttccgtaac tgaaaagtga tatactatat ggatacaaaa
    10861 atgatgtcac aattttctgt tatggataat gaaatgcttg ttcgtacaga ggatggggat
    10921 gtctctgata tttatagagg gtacgctaat cagagaagtc cattcgcttc ttacccttct
    10981 atattaaaaa attcaggtcc tttcccagta agtgggtact gcccgcgtgg ttatcgtgac
    11041 cttggttata taggagcagg ttttcattta tgtggaatat aggctgaaat ataagaaatg
    11101 aggaagaatt tctatgaaaa agtatcaact tctattcaaa ataagtgcag tcttctctta
    11161 cctatttttc gtatttggtc tttctcagct gacgcttatc gtccaaaact attggcaatt
    11221 ttcttctcag ataggcaatt tattctggat tcaaaatatc ttgagtttac tttttattgg
    11281 agtcatgatt gtggttcttg ttaagacagg ccatggttat ctcttccgca ttccaagaaa
    11341 aaaatggctt tggtattcga ttttgacagt attagtggta gtgttccaga tctcttttaa
    11401 cgttcagaca gctaaacatg ttcagtcaac tgcggaaggt tgggctgtat tgattggtta
    11461 tagtgggact aactttgcag agctaggtat ttatatagcc ctgttctttc tggttccact
    11521 gatggaagaa ttgatttata gaggattact gcaacatgct ttctttaagc attcgcgatt
    11581 tggtcttgat ttgcttcttc cttctatttt atttgctctc cctcattttt caagcctgcc
    11641 tagtctgtta gatatcttcg tctttgcaac agttggaatc atctttgctg gtttgacccg
    11701 ctataccaag agcatttatc catcctatgc ggtgcatgtg atcaataata ttgtagcgac
    11761 cttcccgttt ttgctcactt ttctacatag ggtcttgggg taaaaaaaca aaaggcttgc
    11821 ttttcagcca tagaggaggt catcatgtat aaacacttat ttttcctaga ttccaaaact
    11881 ttagatcggt tgacacccta tattctagtc ttggcttctg acaccattnn nnnnnnnnnn
    11941 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    12001 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    12061 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    12121 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    12181 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    12241 nagaatgacg tgtaggaagt ctgtttgttg aggaggataa ttttatggag ttttttgata
    12301 aatttcatgc cttgtgtttt ggatttttag tactaataat tgtcattaca gttccttata
    12361 cgattaacca tgggggtttt tttcaaaatg aatctgcatt gattcttgta agtcttcttg
    12421 taacctcgct gagtgttgct tatgctagaa agtttgaaat gatttctttt gggatgttaa
    12481 gcaagaaaca acttttgctt ttcattgcaa tctttcttct aagtgtactt gagacgctgg
    12541 tttatattca tttcttcgct gtttcttctg gctcaggggt ccaacacttg gcggaagtca
    12601 gcagaggaat ttccctgtct ttgattttaa ctacctcagt ttttggcccc atccaggagg
    12661 aactcatttt cagaggactt cttcaaggtg cggtttttga caattcttgg ttagggcttg
    12721 tgctaacttc ctctctcttt tctttcatgc atggaccttc taatgtccct tcgtttattt
    12781 tttatctact tgggggtttg ttgctgggct ttgcttataa aaagagtcaa aacctatggg
    12841 tttctactct agtccatatg ctttacaaca gttggccact cttatattat ttataaaaat
    12901 tatgaaaagg taagcagaag acggtgctta cctttttcaa gctataatga tacccaagcc
    12961 aatccagagg cttttctttg agaatcgggt tagagtggtt gacgaatagg ccaaaaacta
    13021 gtagaatagt aaggaaactt tatacggagg aaagaaatgg atttgggtga taatgagcta
    13081 acactgactc ccatacctgg gaaaagtggc aaggcttata tgggtagcta tcctgatggg
    13141 aagcgcatct ttgtaaaaat gaacacctct ccaatcctac ctggtctagc tagagaacaa
    13201 attgctccac aattattatg gagtcgtcgt ttggcagatg ggcgtgatat gtgtgctcaa
    13261 gaatggttga caggcaagat attgaccccc tatgatatga atcgtaagca aatcgtcaat
    13321 attttaaccc gtcttcatcg ctcacgtccg ttgatgacac aattgagtcg tttgggctat
    13381 gccatggaaa cacctgtaga tttactacag tcttggcagg aaacggctcc agatgctttg
    13441 cgtaaaaatc attttatcag tgaagtgatg gctgatttac gtcagactat tccaggattt
    13501 agagaggacc atgcgaccat tgtccatgga gatgtacgac atagtaattg gattgagaca
    13561 gatagtggct tgatttattt agtagattgg gattcggttc gcttgaccga tcgcatgttt
    13621 gatgtggccc atatgctctg ccattatatt tcagaacatc agtggaagga atggttgacc
    13681 tactacggtt acaagtacaa tcaaacggta ttaagtaaat tgtattggta tggtcaattg
    13741 tcttatttga gtcagatttc caagtattat atgaaccaag atttagaaaa tgtcaatcgg
    13801 gagattcatg gtttgcgtca tttccgagac aagtatggaa agagaagatg agagttagaa
    13861 atcgtaaagg ggcaacagaa ttactagagg caaatcccca gtatgtggtc ctcaatccct
    13921 tggaagccaa ggcaaaatgg cgggacttgt ttggcaatga taatcccatt catgtggaag
    13981 ttggaagtgg aaagggtgcc tttgtttcag gtatggccaa gcaaaaccct gacatcaact
    14041 atatcgggat tgatattcaa aagtctgttt tgagctacgc tttggacaag gtgcttgaag
    14101 ttggagtgcc taacatcaag ctcttgtggg tagatggttc tgacttaact gactactttg
    14161 aagacggtga gattgatcgc ttgtatctga acttttcaga tccatggccg aaaaaacgcc
    14221 atgaaaagcg tcgtttgacc tacaagacct tcttggatac cttcaaacgt atcttgcctg
    14281 aaaatggaga aattcatttc aagacggata accgtggctt gtttgagtac agtttagtga
    14341 gcttttctca atatggcatg aaactcaatg gtgtctggtt agatttgcat gccagtgatt
    14401 ttgaaggcaa tgtcatgaca gaatacgagc aaaaattctc aaacaagggg caagttatct
    14461 accgagttga ggcagaattt taagagataa cctaaaatta ggctgtacaa gtgcttttgc
    14521 tttacataag ttggcaaacg tgctatactg atagtaagaa tatgaaaagt gaggcgggga
    14581 aatatcttcg cctcttgctt atgaggaggt ggacgcaatc gcaacaatcg tagaattagt
    14641 cagagaagtt gtagaacctg tcatagaagc tccttttgaa ctcgtggata tcgagtatgg
    14701 aaagattggc agtgacatga ttctcagtat ttttgtagat aaacccgaag gaattacctt
    14761 gaacgacacg gcagacttga cagaaattat cagtcctgtc ctagacacca tcaagccaga
    14821 tcccttccca gaacaatatt tcctagaaat taccagtcca ggtttggaac gtcctttgaa
    14881 aaccaaggat gccgtcgctg gagcggttgg aaaatacatc catgtcgggc tctaccaagc
    14941 catcgataag caaaaggtct ttgaaggaac cttgttggcc ttcgaagagg acgagttgac
    15001 tatggaatat atggacaaga cgcgtaagaa aaccgtccaa attccataca gtttagtatc
    15061 aaaagcacgt ttagcagtta aattatagaa aaagaaagga tagcttttga ggattcaaaa
    15121 gtgaagaaaa catgagtaaa gaaatgctag aggccttccg cattttggaa gaagacaagg
    15181 gaatcaaaaa agaagatatc atcgacgcag tagtagagtc gcttcgttcc gcttatcgca
    15241 gacgctatgg tcagtcagac agcgtagcta ttgacttcaa cgaaaaaaca ggtgacttta
    15301 cagtttatac tgtccgtgaa gttgttgatg aagtatttga tagccgtttg gaaatcagct
    15361 tgaaagatgc tcttgccatt aattcagctt atgaacttgg agacaaaatc aagtttgaag
    15421 aagcaccagc tgagtttggt cgtgtagcag cccaatctgc caaacaaacc atcatggaaa
    15481 aaatgcgcaa gcaaacacgt gccatcactt acaatactta caaagaacat gagcaagaaa
    15541 tcatgtctgg tacagtagaa cgctttgaca accgctttat ctatgtcaac cttggtagca
    15601 tcgaa
//
