LOCUS       NZ_FDFR01000001        12154 bp    DNA     linear   CON 22-DEC-2024
DEFINITION  Streptococcus pneumoniae strain 2842STDY5753301, whole genome
            shotgun sequence.
ACCESSION   NZ_FDFR01000001
VERSION     NZ_FDFR01000001.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1
  CONSRTM   Pathogen Informatics
  TITLE     Direct Submission
  JOURNAL   Submitted (04-FEB-2016) SC, Wellcome Trust Sanger Institute, CB10
            1SA, United Kingdom
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_900022985.1-RS_2024_12_22
            Annotation Date                   :: 12/22/2024 02:12:38
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.9
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 2,313
            CDSs (total)                      :: 2,259
            Genes (coding)                    :: 2,086
            CDSs (with protein)               :: 2,086
            Genes (RNA)                       :: 54
            rRNAs                             :: 3, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1, 1 (5S, 16S, 23S)
            partial rRNAs                     :: 2 (5S)
            tRNAs                             :: 46
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 173
            CDSs (without protein)            :: 173
            Pseudo Genes (ambiguous residues) :: 0 of 173
            Pseudo Genes (frameshifted)       :: 71 of 173
            Pseudo Genes (incomplete)         :: 93 of 173
            Pseudo Genes (internal stop)      :: 58 of 173
            Pseudo Genes (multiple problems)  :: 41 of 173
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 15:29:07
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 404542
            Orig. end                         :: 416696
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            FDFR01000001.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..12154
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RiPP-like"
                     /region_number="2"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..12154
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..12154
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[5000:7154](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..7154)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     misc_feature    complement(1065..1075)
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 18.94"
                     /tool="antismash"
     misc_feature    complement(1821..1835)
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 21.98"
                     /tool="antismash"
     misc_feature    2533..2546
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: medium, score: 22.09"
                     /tool="antismash"
     gene            complement(2617..2751)
                     /locus_tag="A1O50_RS13795"
     CDS             complement(2617..2751)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000429437.1"
                     /locus_tag="A1O50_RS13795"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_000429436.1"
                     /transl_table=11
                     /translation="MENLRLSTKRTQAEKVPQTFSLCRELGELTDVYEIVWEKLQGLK"
     gene            complement(2762..3469)
                     /gene="purC"
                     /locus_tag="A1O50_RS02120"
                     /old_locus_tag="ERS409084_00414"
     CDS             complement(2762..3469)
                     /EC_number="6.3.2.6"
                     /GO_function="GO:0004639 -
                     phosphoribosylaminoimidazolesuccinocarboxamide synthase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006164 - purine nucleotide biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /gene="purC"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002312208.1"
                     /locus_tag="A1O50_RS02120"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS409084_00414"
                     /product="phosphoribosylaminoimidazolesuccinocarboxamide
                     synthase"
                     /protein_id="WP_000043313.1"
                     /transl_table=11
                     /translation="MSKQLIYSGKAKDIYTTEDENLIISTYKDQATAFNGVKKEQVAGK
                     GVLNNQISSFIFEKLNAAGVATHFVEKLSDTEQLNKKVKIIPLEVVLRNYTAGSFSKRF
                     GVDEGIALETPIVEFYYKNDDLDDPFINDEHVKFLQIADDQQIAYLKEETRRINELLKV
                     WFAEIGLKLIDFKLEFGFDKDGKIILADEFSPDNCRLWDADGNHMDKDVFRRGLGELTD
                     VYEIVWEKLQELK"
     gene            complement(3639..4988)
                     /gene="comB"
                     /locus_tag="A1O50_RS02125"
                     /old_locus_tag="ERS409084_00415"
     CDS             complement(3639..4988)
                     /codon_start=1
                     /gene="comB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000801614.1"
                     /locus_tag="A1O50_RS02125"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS409084_00415"
                     /product="competence pheromone export protein ComB"
                     /protein_id="WP_054407340.1"
                     /transl_table=11
                     /translation="MKPEFLESAEFYNRRYHNFSSSVIVPMALLLVFLLGFATVAEKEM
                     SLSTRATVEPSRILANIQSTSNNRILVNHLEENKLVKKGDLLVQYQEGAEGVQAESYAS
                     QLDMLKDQKKQLEYLQKSLQEGENHFPEEDKFGYQATFRDYISQAGSLRASTSQQNETI
                     ASQNAAASQTQAEIGNLISQTEAKIRDYQTAKSAMETGASLASQNLAYSLYQSYKSQGE
                     ENPQTKVQAVAQVEAQISQLESSLATYRVQYAGSATQQAYASGLSSQLESLKSQHLAKV
                     GQELTLLAQKILEAESGKKVQGNLLDKGKITASEDGVLHLNPETSDSSMVAEGTLLAQL
                     YPSLEREGKAKLTAYLSSKDVARIKVGDSVRYTTTHDAGNQLFLDSTITSIDATATKTE
                     KGNFFKIEAETNLTSEQAEKLRYGVEGRLQMITGKKSYLRYYLDQFLNKE"
     gene            complement(5001..7154)
                     /gene="comA"
                     /locus_tag="A1O50_RS02130"
                     /old_locus_tag="ERS409084_00416"
     CDS             complement(5001..7154)
                     /codon_start=1
                     /gene="comA"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: TIGR01193"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000668284.1"
                     /locus_tag="A1O50_RS02130"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS409084_00416"
                     /product="peptide cleavage/export ABC transporter ComA"
                     /protein_id="WP_000668303.1"
                     /sec_met_domain="Peptidase_C39 (E-value: 9.2e-43, bitscore:
                     140.0, seeds: 36, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR01193 (E-value: 0.0, bitscore: 1123.8,
                     seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKFGKRHYRPQVDQMDCGVASLAMVFGYYGSYYFLAHLRELAKTT
                     MDGTTALGLVKVAEEIGFETRAIKADMTLFDLPDLTFPFVAHVLKEGKLLHYYVVTGQD
                     KDSIHIADPDPGVKLTKLPRERFEEEWTGVTLFMAPSPDYKPYKEQKNGLLSFIPILVK
                     QRGLIANIVLATLLVTVINIVGSYYLQSIIDTYVPDQMRSTLGIISIGLVIVYILQQIL
                     SYAQEYLLLVLGQRLSIDVILSYIKHVFHLPMSFFATRRTGEIVSRFTDANSIIDALAS
                     TILSIFLDVSTVVIISLVLFSQNTNLFFMTLLALPIYTVIIFAFMKPFEKMNRDTMEAN
                     AVLSSSIIEDINGIETIKSLTSESQRYQKIDKEFVDYLKKSFTYSRAESQQKALKKVAH
                     LLLNVGILWMGAVLVMDGKMSLGQLITYNTLLVYFTNPLENIINLQTKLQTAQVANNRL
                     NEVYLVASEFEEKKTVEDLSLMKGDMTFKQVHYKYGYGRDVLSDINLIVPQGSKVAFVG
                     ISGSGKTTLAKMMVNFYDPSQGEISLGGVNLNQIDKKALRQYINYLPQQPYVFNGTILE
                     NLLLGAKEGTTQEDILRAVELAEIREDIERMPLNYQTELTSDGAGISGGQRQRIALARA
                     LLTDAPVLILDEATSSLDILTEKRIVDNLMALDKTLIFIAHRLTIAERTEKVVVLDQGK
                     IVEEGKHADLLAQGGFYAHLVNS"
     gene            complement(7741..7866)
                     /locus_tag="A1O50_RS12805"
     CDS             complement(7741..7866)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001842754.1"
                     /locus_tag="A1O50_RS12805"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="PncF family bacteriocin immunity protein"
                     /protein_id="WP_000346297.1"
                     /transl_table=11
                     /translation="MDFKSFIIGLVVGIFGPYMDDLIRKKFLKSSEKKTEKSVKK"
     gene            complement(7875..8099)
                     /gene="blpU"
                     /locus_tag="A1O50_RS02135"
                     /pseudo=""
     CDS             complement(7875..8099)
                     /codon_start=1
                     /gene="blpU"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001093487.1"
                     /locus_tag="A1O50_RS02135"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="bacteriocin-like peptide BlpU"
                     /pseudo=""
                     /transl_table=11
                     /translation="MNTKKMSQFEIMDTEMLA"
     misc_feature    complement(8068..8082)
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 21.48"
                     /tool="antismash"
     misc_feature    complement(8226..8239)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 21.29"
                     /tool="antismash"
     misc_feature    8247..8260
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: medium, score: 22.31"
                     /tool="antismash"
     gene            complement(8302..>8602)
                     /locus_tag="A1O50_RS11875"
                     /pseudo=""
     CDS             complement(8302..>8602)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001105201.1"
                     /locus_tag="A1O50_RS11875"
                     /note="frameshifted; incomplete; partial in the middle of a
                     contig; missing N-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /product="transposase family protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="LEMRNIGQAGKILADSGYQGLMKIYPQAQTST"
     misc_feature    8570..8585
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 20.17"
                     /tool="antismash"
     gene            complement(8639..8872)
                     /locus_tag="A1O50_RS02140"
                     /old_locus_tag="ERS409084_00417"
     CDS             complement(8639..8872)
                     /NRPS_PKS="Domain: PP-binding (22-72). E-value: 4.5e-11.
                     Score: 34.9. Matches aSDomain:
                     nrpspksdomains_A1O50_RS02140_PP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000136447.1"
                     /locus_tag="A1O50_RS02140"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS409084_00417"
                     /product="acyl carrier protein"
                     /protein_id="WP_000659556.1"
                     /sec_met_domain="PP-binding (E-value: 1e-10, bitscore:
                     36.8, seeds: 164, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding_2 (E-value: 0.00013, bitscore:
                     17.0, seeds: 2, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKEKEIFDSIVTIIQERQGEDFVVTESLSLKDDLDADSVDLMEFI
                     LTLEDEFSIEISDEEIDQLQSVGDVVKIIQGK"
     aSDomain        complement(8657..8806)
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_A1O50_RS02140_PP-binding.1"
                     /evalue="4.50E-11"
                     /label="A1O50_RS02140_PP-binding.1"
                     /locus_tag="A1O50_RS02140"
                     /protein_end="72"
                     /protein_start="22"
                     /score="34.9"
                     /tool="antismash"
                     /translation="VVTESLSLKDDLDADSVDLMEFILTLEDEFSIEISDEEIDQLQSV
                     GDVVK"
     gene            complement(8878..9870)
                     /gene="plsX"
                     /locus_tag="A1O50_RS02145"
                     /old_locus_tag="ERS409084_00418"
     CDS             complement(8878..9870)
                     /EC_number="2.3.1.274"
                     /GO_function="GO:0043811 - phosphate:acyl-[acyl carrier
                     protein] acyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0008610 - lipid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="plsX"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000717456.1"
                     /locus_tag="A1O50_RS02145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS409084_00418"
                     /product="phosphate acyltransferase PlsX"
                     /protein_id="WP_000717452.1"
                     /transl_table=11
                     /translation="MKKIAVDAMGGDYAPQAIVEGVNQALSDFSDIEVQLYGDEAKIKQ
                     YLTATERVGIIHTDEKIDSDDEPTRAIRNKKNASMVLAAKAVKDGEADAVLSAGNTGAL
                     LAAGFFIVGRIKNIDRPGLMSTLPTIDGKGFDMLDLGANAENTAQHLHQYAVLGSFYAK
                     NVRGIAQPRVGLLNNGTESSKGDPLRKETYELLAADESLNFIGNVEARDLMNGVADVVV
                     ADGFTGNAVLKSIEGTAMGIMGLLKTAITGGGLRAKLGALLLKDSLRGLKKQLNYSDVG
                     GAVLFGVKAPVVKTHGSSDAKAVYSTIRQIRTMLETEVVAQTAREFSGE"
     gene            complement(9867..10637)
                     /gene="recO"
                     /locus_tag="A1O50_RS02150"
                     /old_locus_tag="ERS409084_00419"
     CDS             complement(9867..10637)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006281 - DNA repair [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /codon_start=1
                     /gene="recO"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000616164.1"
                     /locus_tag="A1O50_RS02150"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS409084_00419"
                     /product="DNA repair protein RecO"
                     /protein_id="WP_000616162.1"
                     /transl_table=11
                     /translation="MIQSITSQGLVLYNRNFREDDKLVKIFTEQVGKRMFFVKHAGQSK
                     LAPVIQPLVLARFLLRINDDGLSYIEDYHEVMTFPKINSDLFVMAYATYVAALADASLQ
                     DNQQDAPLFAFLQKTLELMEAGLDYQVLTNIFEIQILTRFGISLNFNECVFCHRVGQAF
                     DFSFKYGACLCPEHYHEDERRCHLNPNIPYLLNQFQAIDFETLETISLKPGIKQELRQF
                     MDQLYEEYVGIHLKSKKFIDSLADWGQLLKEEKK"
     gene            complement(10634..11803)
                     /locus_tag="A1O50_RS02155"
                     /old_locus_tag="ERS409084_00420"
     CDS             complement(10634..11803)
                     /EC_number="2.6.1.-"
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_function="GO:0030170 - pyridoxal phosphate binding
                     [Evidence IEA]"
                     /GO_process="GO:0009058 - biosynthetic process [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Aminotran_1_2 (31-382). E-value:
                     1.7e-64. Score: 210.2. Matches aSDomain:
                     nrpspksdomains_A1O50_RS02155_Aminotran_1_2.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_1_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_5"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DegT_DnrJ_EryC1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1019: aminotransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007519430.1"
                     /locus_tag="A1O50_RS02155"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS409084_00420"
                     /product="pyridoxal phosphate-dependent aminotransferase"
                     /protein_id="WP_000366347.1"
                     /sec_met_domain="Aminotran_1_2 (E-value: 1.1e-63, bitscore:
                     210.4, seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Aminotran_5 (E-value: 4.8e-08, bitscore:
                     27.0, seeds: 34, tool: rule-based-clusters)"
                     /sec_met_domain="DegT_DnrJ_EryC1 (E-value: 3.8e-08,
                     bitscore: 27.7, seeds: 38, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDLTKRFNKQLDKIQVSLIRQFDQAISEIPGVLRLTLGEPDFTTP
                     DHVKEAAKRAIDQNQSYYTGMSGLLTLRQAASDFVKEKYQLDYAPENEILVTIGATEAL
                     SATLTAILEEGDKVLLPAPAYPGYEPIVNLVGAEIVEIDTTENGFVLTPEMLEKAILEQ
                     GDKLKAVILNYPANPTGITYSREQLEALAAVLRKYEIFVVCDEVYSELTYTGEAHVSLG
                     TMLRDQAIIINGLSKSHAMTGWRLGLIFASAAFTAQLIKSHQYLVTAANTMAQHAAVEA
                     LTAGKNDAEPMKKEYIQRRDYIIEKMTALGFEIIKPDGAFYIFAKIPAGYNQDSFAFLK
                     DFAQKKAVAFIPGAAFGRYGEGYVRLSYAASMETIKEAMKRLEEYMREA"
     aSDomain        complement(10658..11710)
                     /aSDomain="Aminotran_1_2"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_A1O50_RS02155_Aminotran_1_2.1"
                     /evalue="1.70E-64"
                     /label="A1O50_RS02155_Aminotran_1_2.1"
                     /locus_tag="A1O50_RS02155"
                     /protein_end="382"
                     /protein_start="31"
                     /score="210.2"
                     /tool="antismash"
                     /translation="VLRLTLGEPDFTTPDHVKEAAKRAIDQNQSYYTGMSGLLTLRQAA
                     SDFVKEKYQLDYAPENEILVTIGATEALSATLTAILEEGDKVLLPAPAYPGYEPIVNLV
                     GAEIVEIDTTENGFVLTPEMLEKAILEQGDKLKAVILNYPANPTGITYSREQLEALAAV
                     LRKYEIFVVCDEVYSELTYTGEAHVSLGTMLRDQAIIINGLSKSHAMTGWRLGLIFASA
                     AFTAQLIKSHQYLVTAANTMAQHAAVEALTAGKNDAEPMKKEYIQRRDYIIEKMTALGF
                     EIIKPDGAFYIFAKIPAGYNQDSFAFLKDFAQKKAVAFIPGAAFGRYGEGYVRLSYAAS
                     METIKEAMKRL"
ORIGIN
        1 tatggtcagc ttggatggct tcaaactgag caaaattttt cttaatcaag tcaaaatcaa
       61 tctctgcaga gagggcttga cctgggatgt agtagatatt ttccccaaca gctttaaatt
      121 ctggagagag caccttacgg ctatctgccg tcgtcacccc aaaggcaacc aaggttggcg
      181 gaacggtcaa ttcttcaaag gtaccagaca tggagtcctt accaccgata gatggcaagc
      241 caagttgaat ctgagcttca atagagccta gaagggcggc tactggctga ccaaaacgct
      301 ctgcttgctt gtccatccgc tcgaaatatt cttggtaaga gaaacgagcc ttagaccagt
      361 tggcaccagc agccaccaaa cgagcagttg cttcgataac cgcataagca gcaccgtggt
      421 atggagacca ttcagctaca tatgggttga aaccttgagc aatgaccgac gcagtatgag
      481 tcacaccgtg ttgaactggc aatttctgca cagatgcctc agttggtgtg agttggtaac
      541 gaccaccaag tgggtgatta accgttgagc gtccaacaga gcagtcaaag acagtctgta
      601 atcctttttg acttgcatgg ttgaggtcag atagaaccgt aagggtatct gattccagtg
      661 tttcagcaga tgtttgacgc tcttctggga gtttgacatc cttgtccaca actttggcat
      721 cgacaaccac gcgcacacca ttggtgtcaa ggaaacgacg ctccaagtca acgattgtct
      781 caccattcca gtgcatgaca agatttggtt tttcagttac tgtcgccacc acaacagcat
      841 caatattttc tttgttacat tcggcaacga aggcatccac atcttcagga cgaaccacga
      901 ccgccatccg ttcttgtgat tcagagatgg caatttctgt accattcaag ccctggtatt
      961 taagaggcac cttgttgagg tcgatttcaa gaccgtctgc caattcaccg atagccacac
     1021 agacaccgcc tgccccaaag tcattggact tcttgatcag acgagtgaca ttgccattac
     1081 ggaagaggcg ctgaatcttg cgttcttcga tggcatttcc tttttgaacc tcagcaccag
     1141 cagtctctac agactcaact gtttgaacct tagaagagcc cgtcgcacca ccgacaccat
     1201 cacgacctgt tttgcctccg agaaggatga tcacatcacc tgcttcaggt ttttcacgga
     1261 caacattgcc cttgggagcc gcaccaacaa cggcaccaag ttccatacgt ttagctacaa
     1321 agcctgggtg gaagtattca cgaacgtagg ttgttgcaag cccaatctgg ttaccatatg
     1381 aagaataacc atgagctgct gttttagaaa tgacttgttg tggcaatttc ccagcgcgag
     1441 tttccgaaat cggtgctgta atatcaccag cacctgaaat acgcatggct tggtaaacat
     1501 aggaacggcc tgacaacgga tcacgaatag ctccaccaat acaggtagcc gctccaccaa
     1561 atggctcaat ttctgttgga tggttgtggg tttcgttttt aaacatgaga agccaaggtt
     1621 ccttgacacc atcaacgtcc acttcaattt caactgagca ggcattgatt tcgtcagaga
     1681 cttccatatc atccaatcgt ccattagcac gctcataacg accgaaaata gtcgccatat
     1741 ccatcaaggt ttgtggtttt tcagaccgac ctaattcctc gcgcatggca atatacttgt
     1801 cataggttga ctgcaattgc ttttgaaatt tagaagctga aaagtcgatg tgtttcaact
     1861 ctgtctcaaa agtcgtatga cggcagtggt cagaccagta agtgtccaaa accttgagtt
     1921 cagtctcagt tggcacgcgc ccgattgact taaagtagtc ttggataaag agcaaatcat
     1981 ccacttccat ggccatccct tgttcggcct tgtagcgagc aaagtcttct gctgtatagc
     2041 tttcaaagaa agtcaatttt ggaatgatct tgtctgactc tgaaaactcc tgcttggcaa
     2101 tccctgtcgt gatatccttg aaacgagaat caactggatt gagcaggtag tttttgacag
     2161 cttccaactc agtcgcatca atatctttat tcaccaagta aagttgggct gtgttgactg
     2221 tcacgtcact cgaacttccc aacaaaagca aggcttcctg tgacgaagct gcacactggt
     2281 caaactgccc tggcagactt tcaatggcaa agaaagcata gttagcaaga tccgcctgca
     2341 cagatacttc atctaaaaca tggtcggtta cctgctcaga gaaaatgtgc ttctctgcag
     2401 gtgcaaacaa gtcctcagcc aagtcaaata catcatatac ttgcacaata cgaatacttt
     2461 tcaagcttga cagtcccaag ttgtgctgga actctctaac caaactctct gacttaacct
     2521 gaaaatcagc ctttttttca acaaaaatac gtttatccat caattcttat tcctttattt
     2581 cagctcttgc aatattccta aacagccttg aggttgttat tttaaaccct gcaacttttc
     2641 ccagacaatt tcgtaaacat cggttagttc acctagttct ctacagagtg aaaaggtctg
     2701 ggggaccttt tcagcctgag tccttttagt tgagagacga aggttttcca ttgcaaacag
     2761 attatttcaa ttcctgcaac ttttcccaaa caatctcata aacgtcggtt agttctccca
     2821 atcctctacg gaaaacatcc ttatccatgt ggttgccatc agcatcccac aagcggcagt
     2881 tatctggtga aaattcgtct gccaagataa tcttgccatc cttatcaaaa ccgaactcta
     2941 gcttaaagtc aatcaattta agcccaatct cagcaaacca gactttcaat agttcattga
     3001 tacgacgcgt ttcttccttc aagtaggcaa tctgctggtc atccgcaatc tgtaggaatt
     3061 tcacatgttc atcattgata aatggatcat ccaaatcatc atttttgtag taaaattcga
     3121 caatcggagt ctccaaggcg attccctcat ccacaccaaa acgttttgaa aaggaaccag
     3181 cagtatagtt gcggagcacg acttccaaag gaataatctt aactttttta ttgagttgtt
     3241 ccgtgtctga aagtttctcc acaaagtgag tcgccacacc agccgcattt aatttctcaa
     3301 aaataaaaga tgagatctga ttattcaaga ctcccttacc tgcaacctgc tccttcttga
     3361 caccgttgaa agcagtcgcc tggtccttgt aagttgaaat aataagattt tcatcctcag
     3421 ttgtatagat atctttagct tttcccgaat agatcaattg ttttgacatt ttaaagttcg
     3481 cctttcgtat tacttgagca cattttacca caaaaaacca aaaaacacaa gaatttaacc
     3541 gaataaatgg cagatgtttt tcaaaaattg taaagaaaaa actgcaagaa gaatctttct
     3601 cacagtttaa aaattattta actctaaaaa cacgaacatt actctttgtt caaaaattga
     3661 tctaaataat aacgtaggta acttttcttg cccgtaatca tctgcaagcg gccttccacc
     3721 ccgtacctaa gtttttcagc ctgctccgaa gttagattag tctccgcctc gattttaaag
     3781 aaattccctt tctcagtctt agtagctgtc gcatcaatac ttgtaatagt agaatctagg
     3841 aaaagttgat tcccggcatc atgagtcgta gtatagcgaa cagaatcacc gaccttgatt
     3901 cttgctacat cttttgaact tagataagct gtgagtttgg ctttcccttc tctttccaaa
     3961 gatggataaa gttgggctag tagggtacct tctgcaacca tgctagaatc actggtctca
     4021 ggattaagat gaagcacccc atcctcactc gccgtaattt tccccttgtc taaaagattt
     4081 ccctgtacct tcttacctga ctctgcctcc aagattttct gggctagaag ggtcaattcc
     4141 tgaccaacct ttgccaaatg ttgggattta agggattcca attgactgct taaccctgac
     4201 gcataggctt gctgggtagc tgaacctgca tactggacac ggtaagtagc aagactagat
     4261 tctaactgag aaatctgtgc ttcaacctgt gcaactgcct gaaccttagt ttggggattt
     4321 tcctcgccct gagacttgta ggactggtaa agagagtagg ctagattctg actggccaag
     4381 gaagcacctg tttccatagc tgacttagct gtctggtaat cgcgaatttt agcctctgtt
     4441 tgactgatga ggttgccgat ttcggcttgg gtttggctag ctgctgcatt ctgggacgcg
     4501 atggtctcat tttgttgcga tgtactagcc ctaagactgc ctgcttgact gatgtagtcg
     4561 cgaaaggtgg cttggtagcc aaacttatcc tcctctggaa agtggttctc cccttcttgc
     4621 aggctctttt gcagatactc caattgcttt ttttgatcct ttagcatgtc caactgactg
     4681 gcataggact ccgcttggac accctctgcc ccttcttggt attgaaccaa aagatccccc
     4741 ttcttaacca gcttattttc ttccaaatga ttgacaagaa tacgattgtt gctagttgac
     4801 tggatatttg caaggatacg actaggttcg acagtagctc tagtggacaa actcatctcc
     4861 ttttctgcaa cagttgcaaa gccaagtaaa aacacgagca gaagggccat gggtacaatc
     4921 acactactgg aaaaattatg gtaacgacga ttataaaact ccgcactttc taaaaattct
     4981 ggtttcatcc tctcctcttt ctagctattg accaaatggg cgtaaaagcc accctgtgca
     5041 agcaaatcag catgctttcc ttcttcgaca atcttgccct gatccaagac aactaccttc
     5101 tctgtccgct cagcaatagt caagcggtga gcaatgaaaa tcaaggtctt gtccaaagcc
     5161 atgagattat cgacaatccg cttctctgtc aaaatatcca aactgctagt cgcctcatcc
     5221 aaaatcaaga ccggcgcatc tgtcaagaga gcacgcgcca aagcgattct ctgacgttga
     5281 ccacctgaaa tccctgcccc atccgaagtc aattctgtct ggtaattcag tggcatgcgc
     5341 tcgatatcct ctcgaatctc tgccaattcg accgcccgta agatatcttc ctgtgtcgtc
     5401 ccctccttgg ctcccaaaag aagattctcc aaaatcgttc cgttaaagac atagggctgt
     5461 tgaggcagat agttgatgta ctggcgcagg gcttttttat caatctgatt gagattgaca
     5521 ccacccagac taatctcccc ttgacttggg tcgtaaaaat taaccatcat cttggccaaa
     5581 gtcgtcttac ctgaccctga aatccccaca aaagccacct tagacccttg gggaacgatt
     5641 aaattgatat ccgacaagac gtctcgacca tagccatact tgtaatgaac ctgcttgaag
     5701 gtcatatctc ccttcatcaa gctcaaatcc tcaactgttt tcttctcctc aaactcagaa
     5761 gctactagat acacttcatt tagacggtta ttggcaacct gcgctgtctg aagcttggtt
     5821 tgcagattga tgatattttc caaaggattg gtaaagtaaa ccagcaaggt attataggta
     5881 atcaactgcc ccaaactcat cttgccatcc atgaccagaa cagcccccat ccagagaatg
     5941 ccgacattaa gtaagagatg ggcaaccttt ttcagagcct tttgctgact ctctgctcga
     6001 ctataggtaa aggatttctt cagataatcc acaaattcct tgtcaatttt ttggtaacgc
     6061 tgactttcac tggtcaagga cttgatagtc tcaataccgt tgatgtcctc aatgatagaa
     6121 gaagacagaa ccgcattggc ttccatggtg tcccgattca tcttttcaaa cggcttcata
     6181 aaggcaaaga taatcactgt gtagatagga agcgccaata aagtcatgaa aaagagattg
     6241 gtattttgtg aaaataaaac aagggaaata atgacaactg ttgacacatc taggaaaatc
     6301 gaaagaatgg tcgaagccag cgcatcgata atactgttag catccgtgaa acgagacaca
     6361 atttcccctg tcctgcgtgt cgcgaaaaag gacataggga ggtgaaaaac atgcttgata
     6421 taggacaaaa tcacgtcaat cgacaagcgt tgccccaaaa caagcaagag atactcctga
     6481 gcgtaagaca agatttgctg gaggatgtag acgatgacta gcccaataga aataatccct
     6541 agtgtcgaac gcatctgatc tggcacatag gtatcaatga tagactgcag ataataagaa
     6601 cccacaatgt taatcacggt taccaagagt gttgccaaaa cgatattggc aatcaagcca
     6661 cgctgcttca ctaatatagg gataaaagag agcagaccat ttttttgttc cttataaggc
     6721 ttatagtctg gactaggtgc cataaaaaga gtcactcctg tccattcttc ctcaaaacgc
     6781 tcacgtggca gtttagtcaa cttcaccccg ggatctggat cggcaatatg aatgctatcc
     6841 ttatcctgcc cagtcaccac atagtagtgg agcaatttcc cttccttaag cacatgggca
     6901 acaaaaggaa aagtcaaatc cggcaagtca aaaagcgtca tatccgcctt aatggctcgc
     6961 gtctcaaaac caatctcctc tgccaccttg accaagccca aagccgtcgt cccatccatg
     7021 gtcgtcttag ccaattctcg caagtgagcc aaaaaataat aactaccata gtagccaaaa
     7081 accatggcta atgaagctac accgcagtcc atctgatcca cttgcggacg atagtgacgt
     7141 ttcccaaatt tcatattcat ctccttttcc ctaatactca atgaaaatca aagagcaaac
     7201 taggaaacta gccgcaggct gctcaaaaca ctgttttgag gttgtagata ggactgacga
     7261 agtcagtcac atatatacgg caaggcgacg ttgacgtggt ttgaatttga ttttcgaaga
     7321 gtataaactc atctgataac aactatctta ccccaatcac taaacaaaaa ctggacttcc
     7381 ttcccaaatg agcctatctc cctcccaact gcactttttg gataaaaaaa taggcagaac
     7441 aagagtcctg cccactaaaa atatgctatt gaaaggaaaa tgatttttta ctgacaccct
     7501 aggcaagctt gaaacaaata aatcattgat agtaacactt acgacatcct ctttattact
     7561 tcaatttcta atgtctctgc tatttctaag ctacctatgg tatgatctat ccctagtcag
     7621 aatagataac accgttctaa attacgattc atagttactc cttttttgac tcgttactat
     7681 aagactcctc tttacatgcg caaaataatt ttgattcaga ttcatcattt atagttttga
     7741 ttatttttta acagattttt ctgttttctt ctccgaagac tttaaaaatt tttttctaat
     7801 taaatcatcc atataaggac caaatatacc aactactaaa ccaataataa aacttttaaa
     7861 atccataatt accactaaca tgtcgcttca taggccacac ctccaagtat agctcctccc
     7921 gcagcaccag ttgctgcacc ttgccatgtt cttgttttaa ttcctagctg aagacctcgt
     7981 gctactcctc ctccaacacc tgctttggca aaatctcccc aattgcatcc gccaccttca
     8041 actcaagcaa gcatctcagt atccataatt tcaaattgtg acatcttttt tgtattcata
     8101 acgaatacct cttttttatt tttaatattt gtcttgttac aaacttgaca agtttagtat
     8161 aacagtatct attaattttt ttcatccaaa tcttgaattg gcatcgaaac gtcttgaatt
     8221 agcttttttg tttcaaaatc atctctattt ttaaaaaaga tgttttctaa tcactttttt
     8281 actattagac ttcctgcaaa actagaatcc tagttcatga ttgataatac cagcaatcaa
     8341 attcattcgt aatccgaagc gtttacgatg atttcgatag gttgttgaaa acattttaaa
     8401 cgtttttact ttggcaaaga tattctcaac cttgcttctc tccttagata gcgcatgatt
     8461 acaggcttta tcttcaactg ttagcggctt gagtttgctg gatttacgtg gaagtttgtg
     8521 cttgaggata tatcttcatg agcccttgat aaccactgtc agccaagatt ttaccagctt
     8581 gtccgatatt tctcatttct aaaaaccatc tacttccgtt gacttggaac tccgattgct
     8641 attttccttg aatgatttta accacatctc ctacactttg gagttggtca atttcctcat
     8701 cgctgatttc gatactaaat tcatcctcca gcgtcaagat aaactccatc aaatcaactg
     8761 agtcagcatc caagtcgtct ttcagactca aggattctgt cacgacaaag tcctctccct
     8821 gtcgctcttg gataatggtc acaatactgt caaaaatttc tttttctttc atctctttta
     8881 ttctcctgaa aattcacgcg cagtctgggc aactacttct gtttctagca tggtacgaat
     8941 ctggcgaatc gtactataaa cagccttggc atcgcttgag ccatgagtct tgacaacagg
     9001 tgccttgaca ccaaacaaga ccgctccacc aacatctgaa taattgagct gttttttcaa
     9061 acctctgagg ctgtccttga gaaggagggc acctagtttc gctcgaagac caccacctgt
     9121 aatagctgtc ttgagcaagc ccatgattcc catagctgtc ccttcgatgg atttgagcac
     9181 agcgtttccc gtgaaaccat ctgccacaac aacatctgca acgccattca tcaaatcacg
     9241 cgcttccacg tttccgataa agttcaaact ttcatcagcc gccagtaatt cataagtttc
     9301 cttacgaagc gggtcgccct tgctactctc tgttccgttg ttgagcaaac caacacgtgg
     9361 ttgcgcaatg ccacgaacat tcttggcata gaaagaacct aggacagcgt attgatggag
     9421 gtgctgggct gtattttctg cattagcacc gaggtcaagc atgtcaaaac ctttcccatc
     9481 tatagtcggc aatgttgaca taagtccagg acggtcgata ttcttgatac gacccacgat
     9541 gaagaatcca gcagccaaca aagcacctgt attcccagcc gaaaggacag cgtctgcttc
     9601 accatctttg acagccttgg ctgccaatac catactggca tttttcttat tccgaatagc
     9661 tctcgtaggt tcatcatccg aatcaatctt ctcatccgta tggataatgc cgacgcgctc
     9721 tgtcgctgtc agatattgct tgattttagc ttcatctccg tagagttgaa cctcgatatc
     9781 tgaaaagtca gatagggctt gattgacacc ctcaacgatg gcctgaggtg cgtaatcgcc
     9841 ccccatggca tctactgcga tttttttcat ttcttttcct cttttagtaa ttgtccccag
     9901 tctgctaggg aatcaataaa tttctttgat tttaggtgaa tcccaacgta ctcttcatat
     9961 agttgatcca taaattggcg tagctcttgc ttgattccag gcttgagcga aatggtctcc
    10021 aaagtctcaa aatcaatagc ttgaaattga ttgagcagat aggggatatt gggattgaga
    10081 tggcaacgtc tctcatcctc atgataatgc tctggacaga ggcaggctcc atatttgaaa
    10141 gaaaagtcaa aagcctgacc aacccgatgg cagaagacac actcattaaa attgaggctg
    10201 attccaaatc gagtcaaaat ttgaatttca aaaatattgg tcaaaacctg ataatccaag
    10261 cctgcttcca tcaactccaa agtcttttgc aaaaaagcaa acaagggagc atcctgctga
    10321 ttgtcctgca aactagcatc tgcaagagct gccacatagg tcgcataggc catgacaaag
    10381 aggtcactat taatcttggg aaaagtcatg acctcatgat agtcttcgat gtaactgagt
    10441 ccgtcatcat tgattcgcaa gagaaatcgt gccagcacca agggctgaat aacaggcgcc
    10501 agcttagact gaccagcgtg tttgacaaaa aacatgcgtt tgccaacctg ctctgtaaaa
    10561 attttgacga gcttatcatc ctcacgaaaa ttgcgattgt aaagcaccaa gccttgactc
    10621 gtgatagact gaatcatgct tctctcatgt actcctcaag tcgtttcatg gcttctttga
    10681 tagtctccat gctggctgca taagataggc ggacgtagcc ttccccgtaa cgtccaaagg
    10741 ctgcaccagg gataaaggca acggccttct tctgagcaaa atccttcaga aaagcaaagg
    10801 agtcttgatt gtagcccgct ggaattttag caaaaatata gaaggcaccg tctggtttga
    10861 taatctcaaa accaagagca gtcatttttt cgatgatata gtcccgacgc tggatatatt
    10921 ccttcttcat gggctccgca tcatttttac cagccgtcaa ggcttctacc gcagcatgtt
    10981 gcgccatggt atttgcggca gtgaccaagt attggtgact cttgattaac tgggctgtga
    11041 aggccgcaga agcgaaaatc agccccaaac gccaacctgt catggcatgc gatttagaca
    11101 aaccattgat aataatagcc tggtctctca acatcgttcc tagagacaca tgggcttcgc
    11161 ctgtgtaggt caattctgag taaacctcat cacagacaac aaaaatttcg tacttgcgta
    11221 aaacagctgc caaggcctct aactgctctc gactgtaggt aattcctgtc ggattggctg
    11281 gatagttgag aataaccgcc ttgagcttat caccctgctc caaaatggcc ttctccaaca
    11341 tctcaggagt caagacaaaa ccattttcag tcgtatcaat ctcaacaatt tctgccccaa
    11401 ctaagttaac aatcggttca tagcctggat aagcaggagc tggcaaaagt accttgtctc
    11461 cctcttccaa aatagccgtc aaagtcgcag ataaagcctc tgtcgcccca attgtaacca
    11521 agatttcatt ttcaggagca tagtccagtt ggtacttttc cttaacaaag tcactagctg
    11581 cctgacgtag agtcagcaga ccactcatcc ctgtatagta ggattggttc tgatcaatcg
    11641 ctcgcttggc cgcctccttg acatggtctg gcgttgtaaa atcaggttcc cccaaggtca
    11701 aacgcaagac cccaggaatc tccgaaatag cctggtcaaa ctgacgaatc aacgaaactt
    11761 gaattttatc taactgttta ttaaagcgct tagttaagtc catagatacc tcctactttc
    11821 aaaacgtatc tctattatac tacaaaagcc ccccgaccgc aaaaatacat tagagaatag
    11881 ctttccactt tctattttac ttttcctctt tacaggtcta taatggtaac agattctatt
    11941 tggaggtttt tatgtcattt ctatcaaaaa atggagcagg catcttggtc tgccttctca
    12001 tttccatcct atcttggtac ttaggaggat tcttccctgt gattggcgca cccgtttttg
    12061 cgatttttat gggcatgctc ctacatccct ttctctcgtc ttataaacaa ctggatgctg
    12121 gattgacctt tagttccaag aaattgctcc agta
//
