LOCUS       NZ_CP120209            22202 bp    DNA     circular CON 19-MAY-2024
DEFINITION  Chryseobacterium indologenes strain Ery-6B chromosome, complete
            genome.
ACCESSION   NZ_CP120209
VERSION     NZ_CP120209.1
KEYWORDS    RefSeq.
SOURCE      Chryseobacterium indologenes
  ORGANISM  Chryseobacterium indologenes
            Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
            Weeksellaceae; Chryseobacterium group; Chryseobacterium.
REFERENCE   1  (bases 1 to 5246911)
  AUTHORS   Xu,S.
  TITLE     Synergistic degradation of erythromycin by symbiotic bacteria Ery-6A
            and Ery-6B and application in simulated water remediation
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 5246911)
  AUTHORS   Xu,S.
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2023) Zhejiang Agriculture and Forestry
            University, School of Environment and Resources, East Lake Campus of
            Zhejiang A&F University, Hangzhou City, Zhejiang Province, Hangzhou
            311300, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SOAPdenovo v. DEC-2022
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Reference-guided Assembly         :: HiFiasm/Unicycler/Flye
            Genome Coverage                   :: 181.0x
            Sequencing Technology             :: Illumina NovaSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_029339075.1-RS_2024_05_19
            Annotation Date                   :: 05/19/2024 05:09:14
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 4,739
            CDSs (total)                      :: 4,629
            Genes (coding)                    :: 4,609
            CDSs (with protein)               :: 4,609
            Genes (RNA)                       :: 110
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 89
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 20
            CDSs (without protein)            :: 20
            Pseudo Genes (ambiguous residues) :: 0 of 20
            Pseudo Genes (frameshifted)       :: 8 of 20
            Pseudo Genes (incomplete)         :: 12 of 20
            Pseudo Genes (internal stop)      :: 4 of 20
            Pseudo Genes (multiple problems)  :: 3 of 20
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 17:37:43
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 4186971
            Orig. end                         :: 4209173
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP120209.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22202
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RRE-containing"
                     /region_number="9"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /tool="antismash"
     cand_cluster    1..22202
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="single"
                     /product="RRE-containing"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22202
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12202](+)"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12202
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
     gene            complement(13..147)
                     /locus_tag="PYS58_RS19130"
                     /old_locus_tag="PYS58_19130"
     CDS             complement(13..147)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="PYS58_RS19130"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="PYS58_19130"
                     /product="hypothetical protein"
                     /protein_id="WP_276283696.1"
                     /transl_table=11
                     /translation="MKNLKKLSREGLRILKGGITQECARIQSEASFANPKLTHLKREL"
     gene            complement(241..1749)
                     /locus_tag="PYS58_RS19135"
                     /old_locus_tag="PYS58_19135"
     CDS             complement(241..1749)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002981722.1"
                     /locus_tag="PYS58_RS19135"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PYS58_19135"
                     /product="vitamin K epoxide reductase family protein"
                     /protein_id="WP_185269582.1"
                     /transl_table=11
                     /translation="MIFDKLINYLKLDKQEFIFQFNSHPNYPSALAFSDTLNFLGVKND
                     AYQLDKEYWDELPEEFIAIVDNSFSLVKKSGSNYSVYSEKAKTLDKEELYKNSTDFVLL
                     FEKTENAENKTAFNFKPVLYAVFAVILIYSFIYQSLFEAIFNLLSLAGVYISLELFNQK
                     FGNTSSVIGSICGATPAAQTTNSCDRIIKQDKTSILGLKFSDFSLIYFAGLAILGLFLP
                     ATAYIVKGFTFVSVLAIGYSLYIQAFVEKTFCRVCLLIISILVAQLVISAFFFQNLTFG
                     IGALLLTAILWVIIFSAVMYSNTLLEQKEELQKSNAKNLRFKRNYELFKSQLLERDKIE
                     FQDTDTFSVGKKDARLRISIISNPYCGFCKDGHKLAESLLKKYPDDVSLQMRFNYTPER
                     SNEKYNALISDLTYIYNNKTEKEFLHAVEEWFETRDENKINILSGGVATSENLNPLIQM
                     TTENSNAGLNFTPILVINGYQFPEKYDREDILFFVDELIEDEEI"
     gene            complement(2063..3145)
                     /gene="gwsS"
                     /locus_tag="PYS58_RS19140"
                     /old_locus_tag="PYS58_19140"
     CDS             complement(2063..3145)
                     /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="gwsS"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR04085"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) SPASM"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007843947.1"
                     /locus_tag="PYS58_RS19140"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PYS58_19140"
                     /product="grasp-with-spasm system SPASM domain peptide
                     maturase"
                     /protein_id="WP_276283697.1"
                     /sec_met_domain="TIGR04085 (E-value: 1.1e-08, bitscore:
                     33.4, seeds: 281, tool: rule-based-clusters)"
                     /sec_met_domain="SPASM (E-value: 4.4e-05, bitscore: 22.0,
                     seeds: 166, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRYFNLFSNILITKGAGRILISDLQRQISDLYPLELYDIIEELKN
                     DSIENILENYDAESKLIIHEYIDFLLEKEYGFITHEDWDNNFPTLSFEYQEVSRISNIF
                     IEIDNVIILDKIRHSVNSLGVKHLVIYCTKELSLEEFQDIDNKFKNSVLEGIEIYAPFH
                     SALDENCFQILNKSTTRIYNFIFYNCNEIPFKTKEVFRFTINFNHENLKISACGKIDLK
                     YFNTNLPKVLEAINHNSCLHKKIGIDIEGNIKNCPLMPEKFGNIHQSSLEEVVIQNDFK
                     KYWNLTKDKIEICKDCEFRYVCTDCRAYTEKNHKNKEGLDLSKPLKCGYNPYTCTWEDW
                     AKNPLKQKVLKHYDLENIPS"
     gene            complement(3142..3327)
                     /locus_tag="PYS58_RS19145"
                     /old_locus_tag="PYS58_19145"
     CDS             complement(3142..3327)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="PYS58_RS19145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="PYS58_19145"
                     /product="hypothetical protein"
                     /protein_id="WP_185249408.1"
                     /transl_table=11
                     /translation="MKKLFKEEKNKLPLTFKFIEKLGHKKSNDKESISTNYIKCETYQT
                     DYLMRERPIKALTRLL"
     gene            complement(3324..4226)
                     /gene="gwsG"
                     /locus_tag="PYS58_RS19150"
                     /old_locus_tag="PYS58_19150"
     CDS             complement(3324..4226)
                     /codon_start=1
                     /gene="gwsG"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007843950.1"
                     /locus_tag="PYS58_RS19150"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PYS58_19150"
                     /product="grasp-with-spasm system ATP-grasp peptide
                     maturase"
                     /protein_id="WP_185249407.1"
                     /transl_table=11
                     /translation="MILIISNNGDSTTTKVVKYLSVMEKKFIRVHEDEFFEIKTDKKRI
                     YLISDRNKFFLDEITSTWYRRGGLKFKRLSYDNNAVNLHMDEHQHWLEDYVIKTLELKK
                     SINKQSNNHVNKLLVLEQAKKIGLNVPKYFLAENTDEVAVKKTITKPITENVILDSVDG
                     NFNGIIYTSVVQEKEKNPFFISFFQEKIEKDFEIRSFYLGGKIWSTAIISQNDEQTKID
                     FRKYNYKKPNRKVRYQLPRDIEEKTHQLMQLLDLSCGSIDFIKSGDHFYFLEVNPTGQF
                     IGLSEICNYSLEKEIAQYL"
     gene            complement(4204..5079)
                     /locus_tag="PYS58_RS19155"
                     /old_locus_tag="PYS58_19155"
     CDS             complement(4204..5079)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002664788.1"
                     /locus_tag="PYS58_RS19155"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PYS58_19155"
                     /product="hypothetical protein"
                     /protein_id="WP_228464032.1"
                     /transl_table=11
                     /translation="MKISSLIRLGILSLIVVLPLISCKKNYITYYNKVNEVDSIYRIAN
                     NPQLAVKKYQEIFKEYDPKNQDRIEEYATYITLADQYHEDFGGKKSLYQLISLMAPYGD
                     EYKKYLPLFNKYGINNSSVEQKITEWKQGFDKKLVDSFKIALVRDQEGRPLDTALTRKN
                     VEKNAKLLIWTFKNYGFPTPQKIGWFPMPTFITHMVEAKKDYPFIKEKLLEYVKSGDVS
                     PRDYARMEDTYLGSHKKITLYGFNMISVKDSAQTDRNRKSLGIPSMKHSAKIRKDYFKK
                     QKQDDTHHIE"
     gene            complement(5149..5352)
                     /locus_tag="PYS58_RS19160"
                     /old_locus_tag="PYS58_19160"
     CDS             complement(5149..5352)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:TIGR04139.1"
                     /locus_tag="PYS58_RS19160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PYS58_19160"
                     /product="TIGR04139 family peptide modification target"
                     /protein_id="WP_185249406.1"
                     /transl_table=11
                     /translation="MKKLTGMKKSFSSLENKKLKRDDLKSVNGSLKSYAIESSAAVTTP
                     GCYEADHYTSNGGTYIGRLEVC"
     misc_feature    complement(5339..5350)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: medium, score: 18.48"
                     /tool="antismash"
     gene            complement(5588..7333)
                     /locus_tag="PYS58_RS19165"
                     /old_locus_tag="PYS58_19165"
     CDS             complement(5588..7333)
                     /GO_function="GO:0043565 - sequence-specific DNA binding
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024242.4"
                     /locus_tag="PYS58_RS19165"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PYS58_19165"
                     /product="AraC family transcriptional regulator"
                     /protein_id="WP_276283698.1"
                     /transl_table=11
                     /translation="MKYIILIILLFSCNLISAQRNQFNSLYEFTYSELKDKFYDYYENN
                     KNSEAKQIANYYLQKAKKENNTLEIAEGYILIHFNKDFPTALQYLDSLTVITKNIKANS
                     YPARTYLIKGNLYYRYDNLKPALDNYILGLQYAKKQHDEKQMAYANMNIAYINSYIGKN
                     AEAAKIFRYYLYNGNNITDDYRRNQMRIALISCYLEINKLDSANILIKEGQKSIPGDKN
                     NQKPNTYSYLSGTYDLRLKKYNTAIIKLTDAYTYFTSTNENTNANYALYNLGKAYQGIK
                     NEEKAIETYVKLDSEVQKFNITYPELREAYTYLIDYYKTNNNQQKQLYYIDRFLIVDKK
                     LDEQIQYLATELPKKYDTPNLLQEKEDIIEELKLRKKILYISLGALLLILLFIIYLYYK
                     SKKTEKEQRKIAQDLILWVEKKNIEERNAEQKNETNDTQTTPTTVSEQSDKASKAISEE
                     VTQFILRELRVFESKELFLKKGTTLASLAKNIKTNTAYLSEIINTHKGKNFTAYLNDLR
                     IDFALNRLVKDKKFRSYKLSVIAEELGYNNEQAFSLAFKKKTGTTLSMYIKEINSINHP
                     QDNTN"
     misc_feature    7528..7545
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: medium, score: 19.94"
                     /tool="antismash"
     gene            7647..7829
                     /locus_tag="PYS58_RS19170"
                     /old_locus_tag="PYS58_19170"
     CDS             7647..7829
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="PYS58_RS19170"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="PYS58_19170"
                     /product="hypothetical protein"
                     /protein_id="WP_185249404.1"
                     /transl_table=11
                     /translation="MKKIIKQEKKLSLKKLQIMKISDMKTINGGNLGGNHLMDFTFEGG
                     DEPPTIKPPMTSSGK"
     misc_feature    complement(7681..7697)
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 24.89"
                     /tool="antismash"
     gene            7829..10000
                     /locus_tag="PYS58_RS19175"
                     /old_locus_tag="PYS58_19175"
     CDS             7829..10000
                     /GO_function="GO:0008236 - serine-type peptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S9"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016169924.1"
                     /locus_tag="PYS58_RS19175"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PYS58_19175"
                     /product="prolyl oligopeptidase family serine peptidase"
                     /protein_id="WP_276283699.1"
                     /sec_met_domain="Peptidase_S9 (E-value: 2.2e-48, bitscore:
                     162.6, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKRLIFIVICVFYVSLNAQKNNPAPSVPVTDEYFGTRIVDEYRNL
                     EDLDNPLTKKWMETQTKYTNSVLDKIPKRHYYLEKRLEFDRTQGYAISDLKITDNDKYF
                     YLKKKGDEKVAKLYYREGYLGKEELLYDPVNFKSVDASHEFVINYISPSLVGDKIAIAM
                     VEKGKELAEVIIMDVKTKYIHPEIITNTTPANIGGIKWLDDNSGFFYTYFPVNDSKSPK
                     FYKNTQAILYKIGTKPEDLIDVFSSAHNHELKIDEEKAPIILDANDKYYVAMLVDNNYY
                     RQTYMILKQELLQGKKNWKPLYYKEDKVRSLQLVNNDVLFLSQYNSQNYTLCKTNIEKP
                     DFKNPEILIPEKKDEVIGQYRVTKDGIYYTTTKNGVEAKLYLYKDGKDISIKLPYPSGN
                     INLQAKGKDFSEIWINCSGWANQEQRFRYDLKTKSFFAENITPIVEYSDFKDVEVQEIT
                     VKARDGEEIPLSLIYNKNIKRNGNNPVLIDSYGSFGISQNPFFARTYLLWVNQGGMVAI
                     AHVRGGGEKGEKWRLGGYKETKPNTWRDLIDCTEYLIKEKYTSSDKVAIWGASAGGITV
                     GRALTERPDLFKAAILELPITNTLRDVLDSDSNVDEYGTVKDPKEFKGLLEMDAYHHIK
                     KGVQYPATLITGGINDPRVLAWEPVKFAAKLMADSASENPVLLQIDYEGGHANNTTVFH
                     GHSNLSDIFAFALWQLGHPDYQPKEEIKK"
     gene            10001..12202
                     /locus_tag="PYS58_RS19180"
                     /old_locus_tag="PYS58_19180"
     CDS             10001..12202
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF016615.4"
                     /locus_tag="PYS58_RS19180"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PYS58_19180"
                     /product="lantibiotic dehydratase family protein"
                     /protein_id="WP_276283700.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 4.4e-145,
                     bitscore: 482.4, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 1e-06,
                     bitscore: 27.5, seeds: 20, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSRFPYQFFEEYIVRTPIFSSKKFLEEVNKDEISDEELRNKFADH
                     SIFMEALYLASPDLHQEIIRWFNGDKQLSQKEHQKLKHTLLKYYSRMSTRCTPFGLFSG
                     VGLGKFSEVCESNKSHVDHFQTDYLIRDTKLDMYFLVSLAQYLVKNQEIRNKLLFYPNN
                     TIYRVGTKIRYIEYQYLGGKRDYIISSAPLSEELQYVLEFSKQGKTIKELTEVLITDEI
                     LQEEALGFIDELIDNQVLISEIEPNVSGGDFLDIVISVLQRLEVKETSILISIKNKLHE
                     LDQNIGNSISVYAEIEKLIMSFGIEYEQKYLFQTDLYRKDKLTLSPHWKKELKRAFSFL
                     NRIRLVRKNSRLEKFKKIFNERFQDEEIALQYVLDSEIGIDYKQNTSLKGIHTYLEDII
                     LPGFERYKNINIELNPFQQVLNEKLQDALLEDQYTLELQEDDLQGLDEQWNDLADTISF
                     FAEIVSDKDKEKLFLHSSTGSSAANPLGRFCSEKSEIHKLTKRIADKEEFLNPDYILAE
                     VIHLPEARIGNVVRRPTIRNYEIPYMAQSILPEENQIPVDDLYISLQNNRFVVRSKRLN
                     KEVRPYLTNAHNYFHNTLPVYHFLSDLYSQEIRGGLHFDWGGLKDIYKFLPRVEYHNII
                     LAKASWKISYKDLIFLESLDKEPFLYELKSWRNKRKIPTWIQWVEVDNTLTLNLENYDM
                     AKLFIQAVKKKKIITIEEFLLNENRNFNHEYIFPMYKLK"
     aSDomain        10484..10738
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_PYS58_RS19180_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="6.10E-09"
                     /identifier="RREFam001.1"
                     /label="PYS58_RS19180"
                     /locus_tag="PYS58_RS19180"
                     /protein_end="246"
                     /protein_start="161"
                     /score="27.5"
                     /tool="antismash"
                     /translation="NNTIYRVGTKIRYIEYQYLGGKRDYIISSAPLSEELQYVLEFSKQ
                     GKTIKELTEVLITDEILQEEALGFIDELIDNQVLISEIEP"
     gene            12209..13045
                     /locus_tag="PYS58_RS19185"
                     /old_locus_tag="PYS58_19185"
     CDS             12209..13045
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lant_dehydr_C"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009086862.1"
                     /locus_tag="PYS58_RS19185"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PYS58_19185"
                     /product="thiopeptide-type bacteriocin biosynthesis
                     protein"
                     /protein_id="WP_276283701.1"
                     /sec_met_domain="Lant_dehydr_C (E-value: 8.5e-44, bitscore:
                     148.4, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKRKFIPGSEWLYVKIYTGVKTADVILGEAIMPLLQQLQDENLIK
                     KWFFIRYNDPRIHLRLRFELSDPMYFSKVLLLINDYLEEYRCSGEISEFIIDVYKREIE
                     RYGEATIEEAEFLFWMSSKSIVYDYLHFDDEEKIIVSLYYIDMCLEYLGLPIQEKLSWI
                     QEFNLAFKQEFNADKKLNNQLDKKYRTFIMKYLEFVETEEYMPFRAAILNNIHESKQAL
                     QHIKHHSDSLQSFFSSVFHMHINRIFVSNQRLFEMIIYDYLSRYYKALFFKSSRII"
     gene            complement(13550..14509)
                     /locus_tag="PYS58_RS19190"
                     /old_locus_tag="PYS58_19190"
     CDS             complement(13550..14509)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007844843.1"
                     /locus_tag="PYS58_RS19190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PYS58_19190"
                     /product="DUF3810 domain-containing protein"
                     /protein_id="WP_346429897.1"
                     /transl_table=11
                     /translation="MIVSFFEKFFEFQKTLHQRVFSWLSFSVGDLIYILLGIVLFYSLI
                     ALFKRKSRHPSLLRILIIGNIFYFTYQIFWGMLYFQTPIIKKLSSQDTPEISKAKKLAL
                     HYLEKCKGTRSSVQEDHNGIFIVTNLKAVQQEILFQQTQLPTYISDKKATQIISIKPSL
                     FKNVMNFTGILGYYNPFTAEAQYNAELPHTFIPFTTAHESSHQLGFAREQEANFIGYLM
                     GVHSSNLELRYSTEYFTLKSLLRFIVEKDPEFVKSVIQNYSPGMKRDRAYEQSFVFRHQ
                     GWLDDFFGYTNNLFLKSNQQEGSVTYSYFIDLLLNYDK"
     gene            complement(14601..16370)
                     /locus_tag="PYS58_RS19195"
                     /old_locus_tag="PYS58_19195"
     CDS             complement(14601..16370)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008257373.1"
                     /locus_tag="PYS58_RS19195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PYS58_19195"
                     /product="MFS transporter"
                     /protein_id="WP_185249400.1"
                     /transl_table=11
                     /translation="MSKTNQPTNYPALYTLVLVFFFWGFIAAGNSIFIPFCKNYFSLDQ
                     FQSQLIDFAFYTAYFLGALLLFIFSTIKGIDIIGKWGYKKSIVYGLLLSALGAAIMIIA
                     VKSNVYYGMLIGLFVVALGFSIQQTAANPFAVLLGDPKTGASRQNLAGGINSFGTSIGP
                     IIVGLALFGTTATVDDDQIKHLALDKVILLYTAVGALFLIAAGIFYFSKKLPDGISTEP
                     MEKAGKARKTLIAMTVLVILFFIPVFSSYNSDEAKNIETLGDEITVLDKTLEKETDAVK
                     ITELKQHITDKKAELETIKHPLEKKRMMYLGGALLVVIVSLVIANSSAKKNAEGWGAMK
                     YPQLVLGMIAILAYVGVEVAIGSNLGELLSMPEFGGHQSSDLAPYISMYWGSLMIGRWT
                     GAIAVFNLNKQQQTIATIVVPFIAFSVIIGINTIAQKDMSHLYFYAVCVAIQVILFLIS
                     KNKPALTLIIFGLFGTAAMITGLLTTGNVAIYAFLSGGLACSIMWPSIFTLAITGLGKY
                     TAQGSAFLVMMILGGGIIPPLQGKLSDIIGIHSSYLIPVLCFVYITLFAYLAKKSLFSQ
                     GINVDVLESEGAH"
     gene            complement(16411..17139)
                     /locus_tag="PYS58_RS19200"
                     /old_locus_tag="PYS58_19200"
     CDS             complement(16411..17139)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1141: acyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015806843.1"
                     /locus_tag="PYS58_RS19200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PYS58_19200"
                     /product="lysophospholipid acyltransferase family protein"
                     /protein_id="WP_185249399.1"
                     /transl_table=11
                     /translation="MAKILNYLWRFWLLLLAFVLTTTLGIPVYILSFSKRHYKYAYKFV
                     RLWCFGMFYGMGFRYDLIKLSDQEKDRSKEYVFISNHTSIMDIMLTCILFPHHPICFVG
                     KKELVKIPIFGTIYQRICVMVDRSSAKSRADVYRRCAEKMEEGNSIAIFPEGGVPDDTS
                     IILDDFKDGAFMLSSKHKSPIAVYTFIGLKEMFPFDSSKGYPGRVKVYFNGIIEPTDSP
                     KDLKTEAYQVIKKTLMENSI"
     gene            complement(17143..17601)
                     /locus_tag="PYS58_RS19205"
                     /old_locus_tag="PYS58_19205"
     CDS             complement(17143..17601)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004916646.1"
                     /locus_tag="PYS58_RS19205"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PYS58_19205"
                     /product="GtrA family protein"
                     /protein_id="WP_185249398.1"
                     /transl_table=11
                     /translation="MKEILIRQKQVLFFIIAGGLSAIVEIGSFKIFSTYLPHFFAKETN
                     FHGIHYPLSNIFSTSCGIISNYFLSIWFVFERGKHSKKKEFAYFMAVSFFSTLLSLGFF
                     QVFYSFIFKENINLFFYTLSPEMISKIAAILLVSILNYSVKKKVIFNG"
     misc_feature    17696..17714
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 24.62"
                     /tool="antismash"
     misc_feature    complement(17699..17714)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: medium, score: 24.48"
                     /tool="antismash"
     misc_feature    17797..17810
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: medium, score: 23.97"
                     /tool="antismash"
     gene            17965..18228
                     /locus_tag="PYS58_RS19210"
                     /old_locus_tag="PYS58_19210"
     CDS             17965..18228
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002981716.1"
                     /locus_tag="PYS58_RS19210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PYS58_19210"
                     /product="hypothetical protein"
                     /protein_id="WP_276283703.1"
                     /transl_table=11
                     /translation="MKRQNKYRKFQLQQKNIEALEKENSRFKRVYSEYENMSNELWNLE
                     NSNGEPVPDDFINAMVLQASYLEDEIEDWLLQFNEKKTKVKH"
     gene            18313..19164
                     /locus_tag="PYS58_RS19215"
                     /old_locus_tag="PYS58_19215"
     CDS             18313..19164
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002981715.1"
                     /locus_tag="PYS58_RS19215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PYS58_19215"
                     /product="BadF/BadG/BcrA/BcrD ATPase family protein"
                     /protein_id="WP_185249396.1"
                     /transl_table=11
                     /translation="MVAIVDSGSTKSDWVILDEFKKVFLKTETIGFNPNFINRELITPE
                     IQKNSNLILVKNSITKVFFYGSGCGVEKNREIIETELKKVFNKAEIIVKEDLMAAAYAA
                     YKGKPAIVCILGTGSNSCYFDGKDVKIELPSLGFLMGDEGSGSAIGKQLVRRYFMKKLP
                     ADLHNEFEAGYKLTIEDALKNMYHAPRPNAYLADFNKFVVERKDHPYFMNMVFEEMKSF
                     FEYQVMPYEEAHDAEINFIGSIAYYYENILRSVAEELNLNVGHVVQKPIESLVDYHIKY
                     IL"
     gene            19180..21465
                     /locus_tag="PYS58_RS19220"
                     /old_locus_tag="PYS58_19220"
     CDS             19180..21465
                     /EC_number="1.1.1.40"
                     /GO_function="GO:0004470 - malic enzyme activity [Evidence
                     IEA]"
                     /GO_function="GO:0004471 - malate dehydrogenase
                     (decarboxylating) (NAD+) activity [Evidence IEA]"
                     /GO_function="GO:0051287 - NAD binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002981714.1"
                     /locus_tag="PYS58_RS19220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PYS58_19220"
                     /product="NADP-dependent malic enzyme"
                     /protein_id="WP_185269584.1"
                     /transl_table=11
                     /translation="MSSNNNRDEKNFSQAALDYHKAEPKGKIEVIPSKPHSSQRDLSLA
                     YSPGVAVPCMEIHDKPETVYDYTGKGNLVAVISNGTAVLGLGDIGAEASKPVMEGKGLL
                     FKIFADINVFDIEIDEKDPDKFIEIVKGIAPTFGGINLEDIKAPEAFYIEQRLKEELNI
                     PLMHDDQHGTAIISAAALINSLQIANKDIDKVKMVVNGAGAAAIACTKLYISLGLKKEN
                     VLMCDSKGVINHKRENLTPEKLDFIAQTDIETLEDAVKGSDVFVGLSKGNVMTPEMLLS
                     MNENPIVFALANPDPEIAYDLALATRKDVIMATGRSDFPNQVNNVLGFPYIFRGALDVQ
                     ATGINEEMKLAAVHAIADLAKEPVPEAVILAYNVQNLQFGREYFIPKPFDNRLITKVSS
                     AVAKAAMESGVARKEITDFEEYEHQLLDRMGRDERLVRMMQSRAKSNPKRITLGNAEEY
                     NVLKAAQILYEEGIAYPSLLGDKKYIQEQMERYGINLDIPIIDPSDDDQKENRKKYRET
                     LWKLRQRKGMNEYKAKRYVRQRDYFGPLMLKHGDTDGLIVGFSKNYTSVLRPVLEVIEK
                     DKGVDKVAAMMMILSEKKPIFFADTSINQNPTSEDLVNIAKMAEFTVKSFAIEPRIAML
                     GFENFAAISDTSKKVAKAVSILHEKYPKMIVDGEIQPDFAMNADHLSDYPFSKLGTTPA
                     NTFIFPNLESANLSYKILRGMKVAQVIGPILMGLKQPVHVLQMRSSVDEIVNLATIAVL
                     DAQRREKK"
ORIGIN
        1 tgttacatgc atttatagct ccctctttag gtgggttagt tttggattcg caaagctcgc
       61 ttcagactga attcttgcac attcctgagt aataccgcct ttcagaatcc ttagtccttc
      121 tcttgaaagt ttctttagat ttttcataat aaatagtttt tgggttgcct actcttttat
      181 agcttttcgg agacgctttt gtttttccta agatagtgaa ttttgaatca cgggctatga
      241 ttaaatttct tcgtcttcta ttaattcatc aacaaagaaa agaatatctt cccggtcata
      301 tttttccggg aactgatagc cgttgattac taagatagga gtgaagttaa gcccggcatt
      361 gctattttct gtagtcattt ggatcaaagg attcaggttt tctgatgtag caactcctcc
      421 agatagaatg ttgattttgt tttcatctct tgtttcgaac cattcttcaa ctgcatgtaa
      481 gaattctttt tctgttttat tgttgtagat ataagtaaga tctgagatca atgcattgta
      541 cttttcattt gatctttcag gagtataatt gaatctcatc tgtaaagaaa catcatcggg
      601 gtatttcttt aaaagacttt ccgcaagttt atgaccatct ttacagaatc cacaataagg
      661 attggaaata atggaaatgc gaagccttgc atcttttttt ccaaccgaaa atgtatcagt
      721 atcctgaaat tctattttgt ctctttctaa taattgactt ttgaaaagtt catagttcct
      781 tttgaatcta agatttttag cattggattt ttgaagttct tctttctgtt caagtaatgt
      841 gttggaatac attactgctg aaaaaattat tacccataaa atagccgtta ataaaagagc
      901 tccaattcca aaagtaaggt tctggaaaaa gaaagcgcta atcactaatt gtgcaaccag
      961 aattgagata atcagcaaac aaactctaca aaacgttttt tccacaaagg cctgaatata
     1021 cagtgagtaa ccaattgcca atacagaaac gaaagtaaac ccttttacaa tataagctgt
     1081 agctggtaaa aataacccca atatggcaag tcctgcaaag taaatgagtg aaaagtctga
     1141 aaactttaac cctaaaatac tggttttatc ttgtttgata attctgtcac atgaatttgt
     1201 tgtttgagca gctggggttg ctccacaaat acttccaatt acactagagg tatttccaaa
     1261 tttttgattg aacagttcca atgaaatata aacacctgct aatgaaagaa ggttgaagat
     1321 tgcttcaaat agactttgat atatgaatga atagataaga attacagcaa aaacagcata
     1381 taaaacaggt ttaaaattga aagccgtttt attttctgca ttttcagtct tttcaaacag
     1441 gagaacaaaa tctgtagagt ttttgtaaag ttcttcttta tctagtgttt tagctttttc
     1501 ggaatagaca gaataattac ttccagattt ttttaccagc gagaatgaat tgtcaacaat
     1561 agcgataaat tcttccggaa gttcatccca gtattctttg tcaagctggt aggcgtcatt
     1621 ttttactccc aagaaattta aagtgtcact gaaggccagt gctgatggat aatttgggtg
     1681 ggagttaaac tggaaaataa attcctgttt atccagtttt aggtagttaa ttagtttatc
     1741 aaaaatcata ttaatatttt catctaaaat acacagatgt tttaaattaa caaaaaaatt
     1801 tttcttttat tagtgagata taaggtgtta ttggtagatt tgatttgaat atcaatattt
     1861 tatttgccag atttggtttg aaaagtattt ttgatatgac atataataaa atttgaagtt
     1921 gcaaaaatag agaatatatg ctttctcgtg ggctttattc catctcccac agatggatat
     1981 gtaaggtttt catggttagt gtttacattc ataattagca catctgtggg ataggagtaa
     2041 tctatttgtg ttctggcttt ttttaacttg gaatattttc tagatcataa tgtttcaaaa
     2101 ctttttgttt caatggattt ttagcccagt cttcccaggt gcaggtatat ggattataac
     2161 cacattttaa aggttttgaa agatcaaggc cttctttatt cttatggttt ttttctgtat
     2221 aagcacggca gtcagtacag acatatcgaa actcacagtc tttacaaatt tctattttgt
     2281 ctttagtaag gttccaatat tttttgaaat cattttgtat cacaacttct tcaagactgg
     2341 attgatgaat atttccaaat ttttcaggca ttaaaggaca gttttttata ttgccctcta
     2401 tatcaattcc aatttttttg tgtaagcagg aattgtgatt gattgcttca agaacttttg
     2461 gcagattagt attgaaatat tttagatcta tctttccgca agcggatatt tttaggtttt
     2521 catggttaaa gttgatcgta aatctaaata cttctttggt cttaaaagga atctcgttgc
     2581 agttataaaa aatgaaatta taaattcttg ttgttgactt attaaggatt tgaaaacagt
     2641 tttcatctaa agcactgtgg aatggagcat atatttctat accttctaaa acagagtttt
     2701 tgaatttatt atctatatcc tgaaactctt caagagaaag ctctttagta cagtaaatta
     2761 ctaaatgttt tacacctaag ctgtttacag agtgccttat tttatcaaga ataataacat
     2821 tgtcaatttc aatgaaaata tttgaaatcc tgcttacttc ttgatattca aaagacaaag
     2881 ttggaaaatt gttatcccaa tcttcatgag ttataaaacc atattctttt tccagcagaa
     2941 agtctatgta ttcatgaata ataagtttag attcagcatc ataattttct aagatgtttt
     3001 caatagaatc atttttcagc tcttcaataa tatcatacaa ttccaaagga taaagatccg
     3061 agatctgtct ctgaagatcc gagatcagga ttcttccagc ccctttggtg attaaaatat
     3121 tactgaatag gttaaaatat ctcataatag tcttgtaagt gcttttattg gtctttccct
     3181 cataagataa tctgtctgat aggtttcaca ctttatgtaa tttgtggaaa tactttcctt
     3241 gtcattagat tttttatggc ccaacttctc aataaattta aaggtaagag gtaatttatt
     3301 tttttcttct ttaaataatt ttttcataaa tattgtgcta tttctttttc taatgaataa
     3361 ttacaaatct ccgacagtcc tataaactga cctgtaggat taacttccaa aaaatagaag
     3421 tgatctccac ttttaataaa atctatcgaa ccacagctta aatccagcaa ttgcatcagc
     3481 tgatgtgttt tttcttcaat atctctggga agctgataac gtacctttct gtttggtttt
     3541 ttataattat attttctaaa atctatttta gtttgctcat cattctgaga aataatagcc
     3601 gtagaccata ttttgcctcc tagataaaaa cttcttattt caaaatcttt ttcaattttt
     3661 tcctgaaaaa atgagatgaa aaatggattc ttctcttttt cttgtactac agaagtgtaa
     3721 atgatgccat tgaaatttcc atcaacagaa tctaatatca cattttctgt aataggcttt
     3781 gtaatggttt ttttgaccgc aacttcatct gtattttctg ctaaaaaata ttttggaacg
     3841 tttaatccta ttttttttgc ttgttctaag accagaagtt tattgacgtg attgttgctt
     3901 tgtttattaa tacttttttt taattccaag gtttttatca cataatcttc cagccaatgc
     3961 tgatgttcat ccatgtggag gttgactgcg ttattatcat aggataaacg tttgaatttt
     4021 aatccacctc tcctgtacca tgtgcttgta atctcatcca gaaaaaattt gtttctatca
     4081 cttatgaggt aaatcctttt tttatctgtt ttaatttcaa aaaactcatc ttcatgcaca
     4141 cgaataaact tcttttccat tacggaaagg tatttgacaa cttttgtagt tgtagagtcc
     4201 ccgttattcg atatgatgag tatcatcttg tttctgtttt ttaaaataat cttttcttat
     4261 tttagcactg tgtttcatac tcggtattcc caggcttttc cgattacgat cggtttgtgc
     4321 actgtccttt acagaaatca tattaaaacc gtagagcgta atctttttat gagatcctaa
     4381 atacgtatcc tccattcttg cataatcgcg aggagataca tctcctgatt ttacatattc
     4441 taataatttt tccttaataa atgggtagtc ttttttagct tccaccatgt gagtaataaa
     4501 ggttggcata ggaaaccatc ctattttttg aggtgttgga aaaccatagt ttttaaaggt
     4561 ccatataaga agttttgcgt ttttctccac attctttctg gtcaatgcgg tatcaagggg
     4621 acgtccttcc tggtcacgaa ccagagcaat tttgaaagaa tccaccagtt ttttatcaaa
     4681 cccttgcttc cattctgtta ttttttgttc tacagagcta ttgttgattc catatttatt
     4741 aaaaagaggt aggtattttt tatattcatc accataaggt gccatcaaag aaattaactg
     4801 ataaaggctt ttttttccgc caaaatcttc atggtattgg tcagcaagtg taatataagt
     4861 agcatactct tcaatgcgat cctgattttt aggatcatat tctttgaaaa tttcttggta
     4921 tttttttaca gctagttgag ggttattggc tattctgtat atgctgtcaa cctcgtttac
     4981 tttattataa taagtaatat agtttttttt acaagatata agaggtaata caacgataag
     5041 agagagaata cccaatctta ttaatgatga aattttcata acggtttaat ttataataat
     5101 atggataaaa ggagggatat tatccctcct tattctttat tcatatactt agcaaacttc
     5161 cagtctacca atgtaagtac ctccattaga tgtataatgg tcagcttcat agcatcctgg
     5221 tgttgtcact gcagcactag attcgatggc ataagacttt aaactaccat ttactgattt
     5281 taaatcatct cttttcagtt ttttgttttc taaagaagaa aaacttttct tcattcctgt
     5341 taactttttc attgttaaaa ttttttttga attaatattt atttgccata catccctggc
     5401 gcgggaaagt gctgatcagc ctttatattt atattttgta ctgtacacat acaaaaaata
     5461 aattttgtgt ttttacctgg agcaaacata cacaagtgta aatagaaaaa aaagtcttga
     5521 ggttttagat ttataaatct acatgtataa atttataaaa taataaaaat aatatattgt
     5581 aaatcagtta attagtgtta tcttgtgggt ggtttatgct attgatttct ttaatgtaca
     5641 tagagagtgt agtccctgtt tttttcttaa atgctaaaga aaatgcttgt tcattattgt
     5701 atcctagttc ctccgcaatg acagataact tgtaggaacg gaattttttg tcttttacca
     5761 atctgtttaa agcaaaatca atacgaaggt cattaagata ggccgtaaag ttttttcctt
     5821 tatgtgtatt gattatttct gataaataag cagtgtttgt ttttatattt tttgctaaac
     5881 tggctaatgt ggtacctttt tttaaaaaaa gttccttgga ttcaaaaact ctcaattctc
     5941 gcaaaataaa ttgagtgact tcttcggata tggctttgga agctttatca ctttgttctg
     6001 aaacagttgt aggagttgtt tgagtatcat tagtttcatt tttttgctct gcatttctct
     6061 cttctatatt tttcttttca acccaaagga ttagatcttg tgcaattttt ctctgttctt
     6121 tttccgtttt tttggattta tagtatagat atataatgaa taagaggatt aataaaagtg
     6181 ccccaagaga aatatagagt attttttttc taagttttaa ttcctcgatg atatcttctt
     6241 tttcttgtaa aagattgggg gtatcatatt tcttaggcaa ttcagttgct aaatattgaa
     6301 tctgttcatc aagttttttg tcaacgatta gaaaacgatc aatatagtaa agttgcttct
     6361 gttgattatt atttgtttta tagtagtcta taagatatgt ataagcttcc cggagttcag
     6421 ggtaagtaat attgaatttt tgtacctccg agtctagctt tacataagtt tctatggctt
     6481 tttcctcatt ctttattcct tgataggctt tacccaaatt ataaagagca taattagcat
     6541 ttgtattttc attggtactt gtgaaataag tataggcatc agttagcttt ataattgcag
     6601 tattatattt ttttaatcga agatcgtaag ttcctgataa ataagaatat gtgttaggtt
     6661 tttgattgtt tttatctcct gggatggatt tctgtccttc tttaattaag atgttggcag
     6721 aatctaactt attgatttca agataacaac ttatgagagc tatgcgcatt tgattacgtc
     6781 gatagtcatc tgtgatatta tttccattat ataaataata tctgaatatt ttagctgctt
     6841 ctgcattttt acctatataa ctattaatgt aagcaatatt catattggca taggccattt
     6901 gtttttcgtc gtgttgtttt tttgcatact gaagccccag aatataatta tccaatgcgg
     6961 gttttaaatt atcataccta taatatagat ttcctttgat caaataggtt ctggcaggat
     7021 aagaatttgc ttttatattt tttgtaatga ccgttaaact atcaagatat tgtagagctg
     7081 tgggaaaatc tttattaaag tgtatcaaga tatatccttc ggctatttct agagtgttgt
     7141 tttctttttt agctttttgt agataataat tagctatttg ttttgcctcc gaatttttat
     7201 tattctcata ataatcataa aacttatcct ttagttctga ataagtaaat tcatataaac
     7261 tattaaattg gttcctttga gcacttatca aattgcagga aaataatagt ataatcagga
     7321 ttatatattt cattattttg taaaaacgca tcaaatttac atttttattt atgaatgcct
     7381 attttctgaa ataacttcaa ttttgagttg ctttttgtag aattataaaa tgaaattgaa
     7441 tttaaatcag ataattattg tttaattaag aaagaaaaag tcttcatcgt taattaataa
     7501 aaatcaattt attataattt aagttttttg ttatcagttt gttatgtgtt gttttatagt
     7561 gtagatttat aaatctataa tatgttttta tttaaatttt gaaaaatatt cttttatttg
     7621 tggttcgaat tttacatata ataaaaatga aaaaaataat taaacaagaa aaaaaattat
     7681 cgttaaaaaa attacaaata atgaaaatta gcgatatgaa aactattaat ggtggtaatt
     7741 tgggaggaaa ccatctaatg gattttactt ttgaaggagg agatgaacca ccaacaatta
     7801 agccgccaat gacatcatct ggtaaataat gaagcgatta atatttatcg ttatttgtgt
     7861 tttttatgtt tccttgaatg ctcaaaaaaa caatcctgct ccatccgttc ctgtgacgga
     7921 tgagtatttt ggtacccgta tcgtagatga gtataggaat ttagaggatt tagataatcc
     7981 tttaacaaaa aaatggatgg aaactcaaac gaaatatacc aattctgttc ttgataaaat
     8041 tcctaaaaga cattattatt tagagaaaag gttagagttt gacagaacgc aaggatacgc
     8101 tatctctgat ttaaaaatta cagataatga taaatatttt tatttgaaga aaaagggaga
     8161 tgagaaagtt gccaagcttt attatcggga aggttattta ggaaaagaag agcttcttta
     8221 tgatcctgtt aatttcaaaa gtgttgatgc aagccatgaa tttgtcatta actacattag
     8281 ccccagtctg gttggtgata aaattgcaat tgcaatggtt gaaaaaggga aagaactagc
     8341 cgaggtaatt attatggatg taaagacaaa atatattcat cctgaaatta ttacaaatac
     8401 aactcctgca aacataggtg gaataaaatg gcttgatgat aattctggat ttttttatac
     8461 atattttccg gttaatgatt ctaaatcccc aaagttttat aaaaacacac aagctatttt
     8521 atataaaatt ggaacaaagc cagaggattt gatagatgtt ttttcttctg ctcataatca
     8581 tgaactaaaa attgatgagg aaaaagcacc tattattctg gatgctaatg ataaatatta
     8641 tgtagccatg ttagttgaca ataattacta caggcagacc tacatgattc tcaaacaaga
     8701 actactgcaa ggtaagaaaa actggaaacc actttattat aaagaagata aagtaaggtc
     8761 tttacaactt gtaaataatg atgtactttt tttatcacaa tataattctc aaaattatac
     8821 tctttgtaaa accaatattg aaaaaccaga ttttaaaaat cccgaaatct taattccgga
     8881 aaagaaggac gaagttattg ggcaatatag agttactaag gatgggattt attacacgac
     8941 aaccaaaaac ggagtagagg caaagctata tctgtataaa gatggtaaag atatttcaat
     9001 taagcttcct tacccatcag gaaatataaa tttacaggca aaaggaaaag acttttcaga
     9061 gatttggatt aactgttctg gatgggcaaa tcaggaacaa cggtttagat atgacctaaa
     9121 aacaaaatct ttttttgctg aaaacataac acctattgtt gaatattctg attttaaaga
     9181 tgttgaagtt caggaaataa ctgtaaaagc aagagacggt gaagaaatac cattatcact
     9241 catatataac aaaaatataa agcgaaatgg taataatcca gtattaattg attcttatgg
     9301 ttcttttgga atttcccaaa acccattctt tgcccgcact tatctattat gggtaaatca
     9361 aggagggatg gtagctattg ctcatgtaag aggtggtggc gaaaaaggag aaaaatggcg
     9421 tttgggaggc tataaggaaa caaaacctaa tacttggagg gatttgatag actgcacaga
     9481 atatttaata aaggaaaaat atacatcaag cgataaagta gcgatttggg gagcgagtgc
     9541 tggcggaatt acagtaggaa gagcattaac agaaagacca gatttattta aagcagcaat
     9601 tttagaacta cctatcacaa atacattaag ggatgtgctt gacagcgata gtaatgtgga
     9661 cgaatatgga acagtaaaag acccaaaaga atttaaaggt ctattagaaa tggatgctta
     9721 ccatcatatc aaaaaaggag tgcaatatcc tgctacactt ataacaggtg gaataaatga
     9781 tccacgagta ctggcttggg agcccgtaaa gtttgcagct aaactaatgg cagatagtgc
     9841 atcagaaaat ccggttttac tccagataga ttacgaaggt gggcatgcca ataatacaac
     9901 tgtttttcac ggacattcaa acctttcaga tatttttgct tttgcccttt ggcaactggg
     9961 gcatcctgat tatcagccta aagaagaaat aaaaaaataa atgtctcgtt ttccctacca
    10021 gttttttgaa gaatatattg tacgtactcc catattttca agtaagaaat ttcttgaaga
    10081 agtaaataaa gatgaaattt cagacgaaga attaagaaat aaatttgctg atcattccat
    10141 ttttatggag gctctttatt tagcttcacc tgatttacat caagaaatta taagatggtt
    10201 caacggagat aaacaacttt cgcaaaaaga acaccaaaaa ctaaaacata ctttattaaa
    10261 atattatagc cggatgagta cacgttgtac tccattcggc ttattttctg gagtaggttt
    10321 gggaaaattt agtgaagtct gtgaaagtaa taaatcacac gtagatcatt ttcaaaccga
    10381 ttatttaatt cgggatacga aactagatat gtattttctt gtatctctgg cacaatattt
    10441 agtcaaaaat caggaaatca ggaataaact tttgttttat cctaataata ctatttatag
    10501 agtaggaaca aaaatccgtt atattgaata ccaatacttg ggaggaaaaa gagattatat
    10561 catttcttcg gcccctcttt ctgaagagct acagtatgta ttggagtttt caaaacaagg
    10621 aaagacaata aaagagctta cagaggttct gataacagat gaaatactcc aagaagaagc
    10681 tttagggttt atagatgaac ttattgataa tcaagttctc atcagtgaga ttgaaccgaa
    10741 tgtttcagga ggtgattttt tagatattgt aatttctgtt ttacaaagac ttgaggtaaa
    10801 ggaaactagt atcttaattt ctataaaaaa taaacttcat gaattagacc aaaatattgg
    10861 aaactcaatt tcagtttatg ctgagattga aaaacttatt atgtcttttg ggatagaata
    10921 tgagcagaaa tatctatttc aaaccgactt atacaggaaa gacaaattga ctctatcacc
    10981 acactggaaa aaggaactta aaagagcttt cagttttttg aatagaataa ggttagttcg
    11041 aaagaatagc cgcctggaaa aatttaaaaa aatcttcaat gaaagatttc aagatgagga
    11101 aatagcttta caatatgttc ttgattccga aattggtatt gactataaac aaaatacctc
    11161 attaaaagga atccatactt atttagaaga cataatactt ccaggttttg aaagatataa
    11221 aaatataaat attgaactga atccgtttca acaggttctt aatgaaaaat tgcaggatgc
    11281 cttgttagaa gatcagtata cgttagaatt acaagaagat gatcttcagg gattagatga
    11341 acaatggaat gatctggccg atactatttc tttttttgcg gaaattgtgt cagacaagga
    11401 taaggaaaaa ctattcctgc atagcagtac aggaagtagt gccgcaaatc cattaggccg
    11461 attttgttct gaaaaatctg aaattcataa gttgacaaaa aggattgcag ataaagaaga
    11521 atttctcaat cctgattaca ttttagcaga agtgattcac ttacctgaag caagaatagg
    11581 aaatgttgtt agaagaccta caataagaaa ttatgagatt ccttacatgg cccaatctat
    11641 tttgccagaa gaaaatcaaa tacctgtaga tgatctttat atttcattac aaaataatag
    11701 atttgttgta cgatccaaaa gattgaataa agaagtaagg ccttatttaa cgaatgccca
    11761 taactatttt cacaataccc tgccggttta tcactttctc tctgatcttt attcacagga
    11821 aataagaggc gggttgcatt ttgactgggg tggactgaag gatatctata aatttctacc
    11881 aagagtagaa tatcacaata tcattcttgc caaagctagc tggaagatct catataaaga
    11941 ccttatcttt ttagaatcat tagataaaga gcctttctta tatgaattaa agagttggag
    12001 gaataaaaga aaaattccta catggatcca atgggtagaa gtcgataata ctttaactct
    12061 gaaccttgaa aattatgata tggctaagct ttttattcag gcagttaaaa agaaaaaaat
    12121 aatcacgata gaagaatttt tattgaatga gaatagaaat tttaatcatg agtatatatt
    12181 cccaatgtat aaattaaaat aaattttgat gaaaagaaag tttattcccg gaagcgagtg
    12241 gctgtatgtc aaaatttata caggtgttaa aactgcggat gttattttgg gggaggctat
    12301 tatgccttta ttacagcaat tacaggatga aaacttaatt aaaaaatggt tctttatccg
    12361 ttataatgat ccacggattc atcttaggct tcgttttgag ctttcagacc ctatgtattt
    12421 tagtaaagtt cttttattga tcaatgatta cttggaagaa tatagatgtt caggagaaat
    12481 atcggaattt ataatagatg tctacaagcg ggaaattgaa cggtatggtg aagcaacaat
    12541 tgaggaagct gagtttttat tttggatgag tagtaagagt attgtttatg attaccttca
    12601 ttttgatgat gaagagaaaa ttatagtatc actttattat attgatatgt gtttagaata
    12661 ccttggattg cctattcagg aaaaattaag ctggatccaa gaatttaatc ttgcttttaa
    12721 gcaggaattc aatgcagata aaaagctaaa caatcagctt gataaaaaat acagaacatt
    12781 tattatgaaa tatctggagt ttgttgaaac cgaggagtac atgcctttta gagctgccat
    12841 tttaaataat attcatgaat ctaaacaagc cctgcaacat ataaaacatc attcagattc
    12901 tcttcagagt tttttttcca gtgtgtttca catgcatatc aatcgaatat ttgtttccaa
    12961 tcaacgactg tttgaaatga ttatttatga ttatttatcc agatattata aggctctttt
    13021 ttttaaaagt agcaggataa tctaatattg ttaatatttg caacatattc tagaatcata
    13081 tcgcactttt taatgattat tttgggttta aaccggatgt aattctattg aaaaatactg
    13141 ctgaaattta agaactattc aaaagaaaaa tgtagagata ttttcaatta taaagagaat
    13201 aactctaact ttttaatcag gtgaaatact taataaatgg aatattttat gtttaaacaa
    13261 atatttgatt ttgtaaattt ttcgcagttt aactataatt tgtttattat tttaatagtg
    13321 tatgttaggc ttgattacaa ttcatattaa gtgtgttcga actcaaaaaa acttaaaaaa
    13381 tcataaagtt ttcataaagt ttcaaaaaaa aaaagaaatg tttttgtatt tataaaatat
    13441 gtcgtacttt tacatcgcct tgaatgaggg aacaagtcaa ggtaataaat tttttttcat
    13501 catttgtgtt tttagaatcg tatcgcctga tacgattctt tttttatgcc tatttatcat
    13561 agttcagaag gagatcaata aagtaggaat aagtaactga accttcctgt tggttgctct
    13621 tgagaaagag attattagtg tatccaaaga agtcatccag ccaaccttga tgtctaaata
    13681 cgaagctttg ctcatacgca cggtcccttt tcattccggg agaataattt tggataacag
    13741 attttacaaa ttctggatct ttttcaacga taaaacgtaa aagacttttt aacgtaaaat
    13801 attcggtgct gtatcttaat tccagattgc tggaatgaac tcccataaga tatccgataa
    13861 aattagcctc ctgttctctt gcaaaaccaa gttgatggga actctcatgg gctgttgtaa
    13921 aagggataaa agtatgtggt aattcggcgt tatattgtgc ttctgcggta aaaggattgt
    13981 aatatcctaa tatacctgta aagttcatta catttttaaa taaactaggc ttaatagaaa
    14041 taatttgagt cgccttttta tccgaaatat aggttggaag ctgagtttgc tggaacaaaa
    14101 tttcctgttg tacagccttc aggttggtaa caatgaaaat accattatga tcttcttgta
    14161 ctgatgaacg ggtacctttg catttttcca gatagtgcaa ggctagtttt tttgctttac
    14221 ttatttcagg agtatcctgg ctggaaagct ttttaatgat tggagtctga aaatagagca
    14281 tcccccagaa aatctgatac gtaaaataaa agatatttcc aatgataagg atccttaata
    14341 gggaaggatg cctgcttttc ctcttaaata aagcaataag gctataaaaa agaacaattc
    14401 ccaataagat atagataagg tcacccactg aaaaagaaag ccagctaaag accctctgat
    14461 gaagcgtttt ctggaattcg aaaaatttct caaaaaaaga aactatcaat aaagattttg
    14521 agaaaccata aaataaaaga aattgggcaa gtaatgcacc tgcccaaaat cttttctttt
    14581 tatatatatg tagtctattt ttagtgtgca ccttcagatt ctaaaacgtc aacgttaatt
    14641 ccctgactaa ataaagattt tttagccaga taagcaaata aagtaatgta cacaaagcac
    14701 aatacaggaa ttagataaga actgtggatt ccgataatgt cagaaagctt accctgaagt
    14761 ggtggaataa tacctccacc aaggatcatc atcacaagga aagcagatcc ctgagctgta
    14821 tatttcccta atcctgtaat agccagtgtg aaaatagatg gccacatgat actgcaggca
    14881 agacctcccg aaaggaatgc atagatcgca acatttcctg tagtcagtaa ccccgtaatc
    14941 atagcagcag ttccaaacaa tccaaaaata attagcgtta atgccggttt atttttactg
    15001 attaagaata atataacctg aattgctaca caaactgcat aaaaatatag atgtgacatg
    15061 tctttttgag caatcgtatt gattcctata attacagaaa aagcaataaa aggaacaaca
    15121 atggtagcaa tggtctgttg ttgtttattt aggttgaaaa ccgcgatggc acctgtccat
    15181 cttccaatca ttaaacttcc ccaatacata gaaatataag gggcaaggtc tgaagattga
    15241 tgtcctccga actcgggcat gcttaaaagc tctcccaggt tacttcctat ggcaacttct
    15301 actcctacat aggcaagaat agcaatcatt cccaatacca attgtggata tttcatagct
    15361 ccccaacctt cagcattttt cttagcactg gaattcgcaa ttacaagaga aacaatcaca
    15421 acaagtaatg caccaccaag gtacatcatt ctttttttct ccaaaggatg cttgatcgtt
    15481 tccagttcgg ccttcttatc agtaatatgt tgtttaagtt ctgtgatttt tactgcatca
    15541 gtttcttttt caagagtttt gtctaatacc gtaatttcat cgcctaaagt ttcaatattt
    15601 ttagcttcat cagaattata gctgctgaat accgggataa agaaaaggat aacaagaact
    15661 gtcatggcaa ttaatgtttt tcttgctttt ccagcctttt ccataggttc agttgaaatt
    15721 ccgtcaggaa gtttctttga aaagtaaaag attcctgcag caataaggaa tagagctcct
    15781 acagcggtgt aaagcagaat tactttatca agagccagat gtttaatctg atcatcatct
    15841 acagtggccg tagttccgaa aagggctagt ccaacgatga ttggcccgat agatgtaccg
    15901 aaagagttaa ttccacctgc aaggttctgc ctgctggctc cggttttagg atctccaagc
    15961 aatacagcaa aagggttcgc cgcagtctgc tgaatagaga aacctaatgc tactacaaag
    16021 agcccgataa gcattccata atatacattg cttttaacgg caataatcat gatggcagca
    16081 ccaagggcag agaggaggag tccgtagaca atactctttt tatagcccca ttttccgata
    16141 atgtcaattc cttttatagt actgaatata aaaagcaata acgctcccag gaaatacgca
    16201 gtataaaaag caaaatctat taactgggac tgaaattggt cgagagaaaa atagttttta
    16261 cagaagggga tgaaaatact attgccggca gcaataaaac cccagaaaaa aaatacaagt
    16321 acaagtgtgt acaatgccgg gtaattagtc ggctgattgg tttttgacat attttattga
    16381 aaatttcgca aacaaatata attaattctt ttaaatagaa ttctccatca atgttttttt
    16441 aattacttga taagcctctg tttttaagtc ttttggagaa tcagtaggtt ctataattcc
    16501 attgaaataa actttgactc ttccagggta gcctttagag ctatcaaaag gaaacatttc
    16561 tttaagcccg ataaaggtat aaactgcaat gggagattta tgttttgatg acaacataaa
    16621 ggctccatct ttaaaatcat ccagaataat ggaagtatca tcaggcacac ctccttcagg
    16681 aaaaatggca atgctgttgc cctcctccat tttttcagca catctccggt atacatcagc
    16741 acggcttttt gcgcttgatc tgtctaccat tacacatatt ctttggtaaa tagttccgaa
    16801 aataggaatc ttaacaagtt ctttttttcc aacaaaacaa attgggtggt gcggaaaaag
    16861 aatgcaggtg agcataatat ccataatcga agtgtggttt gatatgaaaa catactcttt
    16921 acttctgtct ttttcttgat cagaaagttt aatgagatca tatcggaagc ccataccgta
    16981 aaacataccg aaacaccata accggacaaa tttataagca tatttatagt gcctcttgct
    17041 aaaagataaa atataaacgg gaatcccaag agtggttgtt agaacaaatg ctaataacaa
    17101 cagccagaat ctccagagat aatttagaat ttttgccaca gtttaaccgt taaaaattac
    17161 tttctttttt accgaataat taagaatgga aaccagcagg attgctgcaa tcttgcttat
    17221 catttccgga ctcaaggtat aaaaaaataa attgatattc tccttaaata taaaactgta
    17281 aaacacctga aagaaaccga ggcttaataa agtagagaaa aaagataccg ccatgaaata
    17341 agcaaactct tttttcttag aatgctttcc tctttcaaaa acaaaccaga tgctcagaaa
    17401 ataattactg atgatcccac agctggtaga gaaaatatta cttaaaggat aatggatacc
    17461 atgaaagtta gtttcttttg caaaaaaatg aggaaggtaa gtgctgaata ttttgaagct
    17521 gccaatctca acaattgcgc tcagccctcc agcaataatg aagaacaaaa cctgcttctg
    17581 gcgtataagt atttctttca tttaattagt ataaaaactg aaaatatatc tatattgtat
    17641 tgaatactag ttttttttgt aagagaaaca atcagtattt ccttagatcc tgtgtattga
    17701 taatgctttt caattatttt aaatcaggat tctttacaat atcaatctgc aaatttataa
    17761 ctatatgtta aacactgaaa aaagttgtta aaatattttt ttaaataaaa attatgtcta
    17821 attttaataa gcggaatgat gtcactataa cctgataata aattcatttt caaatccttg
    17881 tgataatggt tttttctatc ttgtaatgcc cagttgaaag catactactc taaattttta
    17941 tgaccaattg ataataatat ttgtatgaaa cgtcaaaaca aatacagaaa attccagctt
    18001 cagcagaaaa atattgaagc gctggaaaaa gaaaactccc gcttcaaacg agtgtattct
    18061 gaatatgaaa atatgtctaa tgaactttgg aatcttgaaa attccaacgg tgaacctgtt
    18121 cctgatgatt ttatcaacgc tatggtgctg caggcatctt atctggaaga tgaaattgaa
    18181 gattggcttc tccagttcaa tgaaaagaaa actaaggtta aacattaatg attttagaca
    18241 gcttccagtt tgtttttaaa gctatttgaa gataaattca taatttagca cccttaaatt
    18301 aaaatcaaaa atatggttgc tattgtagat agtggttcta ctaaatcgga ctgggtaata
    18361 cttgatgagt tcaaaaaggt ttttctgaaa actgaaacca tcggctttaa tccgaatttt
    18421 attaacagag aacttatcac tcctgaaata cagaagaaca gcaacctgat attggtcaaa
    18481 aattcaatca ctaaagtctt tttctatggc tctggatgcg gtgtggaaaa aaatcgcgaa
    18541 atcatagaaa ctgagcttaa aaaagtattt aacaaagcag aaatcattgt aaaagaagac
    18601 ctgatggcgg ctgcttatgc tgcctataaa gggaaacctg cgatcgtatg cattttaggg
    18661 acaggatcaa actcatgtta ctttgatggt aaagatgtga agattgaact gccgtccctt
    18721 gggtttctga tgggagatga gggaagcgga agtgcgatcg gaaaacagtt ggtacgcaga
    18781 tacttcatga aaaaacttcc tgcagatctt cataatgaat ttgaggcagg ctataaactt
    18841 accatagaag atgcattgaa aaatatgtat catgctccaa gaccaaatgc ttatttagct
    18901 gatttcaata aatttgttgt cgaaaggaaa gatcatcctt actttatgaa catggttttc
    18961 gaagaaatga aaagcttctt cgaatatcaa gtgatgcctt atgaggaagc tcatgatgcc
    19021 gaaatcaatt ttataggctc cattgcttat tattatgaaa atattttacg ctctgtagcg
    19081 gaagaactta atttaaatgt gggacatgta gttcagaaac caattgaaag cttagtagat
    19141 taccacatta aatatatact ctaacaaaaa ataaaacgta tgtcaagtaa caacaatcgc
    19201 gacgaaaaga attttagtca ggccgcgtta gattatcata aagcagaacc caaagggaaa
    19261 atcgaagtta taccatccaa gccacactca tctcaaagag atttatcatt ggcttactct
    19321 cccggagtag cggttccttg tatggaaatt cacgataagc cggaaacagt atatgattac
    19381 acaggaaaag gaaaccttgt agcggtaatc tctaacggta ctgcggtact tggattggga
    19441 gatattggtg cagaagcttc aaagcctgta atggaaggga aaggtctttt gtttaaaatt
    19501 tttgctgata tcaacgtttt tgatattgaa attgatgaaa aagatcccga taaatttatt
    19561 gaaatcgtta aaggaattgc tccaacattt ggaggaatca accttgaaga tattaaagct
    19621 cctgaggcat tctatataga gcaaagacta aaagaggaat tgaatattcc tttgatgcac
    19681 gatgatcagc acggaactgc tattatttct gctgctgcat taatcaattc attacagatt
    19741 gccaataaag atattgataa agtgaaaatg gtggtgaacg gagccggagc tgctgccatc
    19801 gcttgtacta aactttacat ttcattagga cttaaaaaag aaaatgtcct gatgtgtgac
    19861 agtaaagggg taatcaatca taagagagaa aaccttactc ctgaaaaatt agatttcatt
    19921 gcccagacgg atattgaaac attggaagat gctgtaaaag gatctgatgt tttcgtagga
    19981 ttatcaaaag gaaatgtgat gactcctgaa atgttgttaa gcatgaatga gaaccctatc
    20041 gtgtttgctt tagcgaatcc ggatcctgaa attgcttatg atttagctct tgcaacccgt
    20101 aaagatgtta tcatggcaac tggaagaagt gattttccta atcaggtaaa caatgtatta
    20161 ggattccctt atattttccg tggtgcgtta gatgttcagg cgacaggaat taatgaagaa
    20221 atgaagcttg cggcagtaca tgctattgct gatcttgcaa aagaaccggt tccggaagct
    20281 gtaattcttg cttataatgt tcagaatctg cagtttggaa gagaatattt cattccaaag
    20341 ccatttgaca acagattgat tacaaaagta tccagtgcgg ttgctaaagc agctatggaa
    20401 agtggtgttg caagaaaaga aattactgat ttcgaagagt acgagcacca gcttttagac
    20461 agaatgggca gagatgagag attggtaaga atgatgcaga gccgtgcaaa atccaatccg
    20521 aagagaatta ctcttggaaa cgctgaagaa tataatgtat taaaggcagc acaaattctt
    20581 tacgaagaag gaattgctta tccgagtctt ttaggagata aaaaatacat ccaggaacag
    20641 atggaacgct acggaatcaa tctggacatt ccaatcattg atccaagtga tgatgatcag
    20701 aaagaaaaca gaaagaaata cagagaaaca ctttggaagc ttcgtcagag aaaaggaatg
    20761 aacgagtaca aagcgaagag atatgttcgc cagagagatt atttcggacc tttaatgctt
    20821 aaacatggcg atactgatgg tcttattgtt ggtttctcta aaaattatac ttctgtatta
    20881 cgtccagtgt tagaagtgat tgaaaaagat aaaggcgtag ataaagtagc ggcaatgatg
    20941 atgattttat cggaaaagaa accaattttc ttcgcagata catcgatcaa tcaaaatcct
    21001 acatctgaag atcttgtgaa tattgctaaa atggctgaat ttacagtgaa atctttcgct
    21061 atcgaaccta gaattgcaat gcttggattt gaaaactttg ctgccatttc ggatacctcc
    21121 aaaaaagtgg cgaaagcagt aagcatcctt catgagaaat accctaagat gatcgttgat
    21181 ggtgagattc agccggattt tgcaatgaac gcagatcatt taagtgatta tcctttctca
    21241 aaattaggaa caacaccagc caacacattc atcttcccga atcttgaaag tgccaacctt
    21301 tcttacaaaa ttctaagagg aatgaaagta gcacaggtaa tcggaccaat actgatggga
    21361 ttaaaacaac cggtacacgt tcttcagatg cgttcaagcg tagatgagat cgtaaacctt
    21421 gcaacaattg ccgttcttga cgcgcaaaga agagagaaaa agtaatttat ttactgtata
    21481 tatttaaaaa gcatcttgta aaagatgctt ttttgtttgt atatctgctc attcttatag
    21541 cagctgatac cactaatgat aatgttttta ttacctttga ggtcaatata tagtgatata
    21601 ctctcacctt aaagctggtg agataaaaaa acaaaactaa taatctgata tatgcaattg
    21661 aaaacgatca tagcaattct gcttttctca ttcgctcaaa gtttttattc tcaggatatg
    21721 agaatagact ataatcttat ctataaagaa gactctttaa gtactgaaac agtatccaaa
    21781 aaaatggtac tcctcattca ggatggagaa tccagatttt gcacggaaaa acaatatcag
    21841 gtagattctc tgagaagtat tggcttttat ggttttgccg tgggagacta tgtttttgat
    21901 gcagtaagag ataagcagaa tagaatctca aagcattact atatgtcagc cgatgtatat
    21961 aaactgacag aatctataca gttagactgg aaaatagaaa aagagattgc tgaaaaatat
    22021 ggttataact gccagaaagc aacattaagc tataaaggta gagtttggga agcttggttt
    22081 acacaggata ttcccgtgca ggaaggtccc tatgttttca aagggttgcc aggtttgatt
    22141 gtggagatgg aagataaaag tcattcctat aaattctcct tttcagggtt gaaaaaaggt
    22201 tt
//
