LOCUS       NZ_CP120209            21068 bp    DNA     circular CON 19-MAY-2024
DEFINITION  Chryseobacterium indologenes strain Ery-6B chromosome, complete
            genome.
ACCESSION   NZ_CP120209
VERSION     NZ_CP120209.1
KEYWORDS    RefSeq.
SOURCE      Chryseobacterium indologenes
  ORGANISM  Chryseobacterium indologenes
            Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
            Weeksellaceae; Chryseobacterium group; Chryseobacterium.
REFERENCE   1  (bases 1 to 5246911)
  AUTHORS   Xu,S.
  TITLE     Synergistic degradation of erythromycin by symbiotic bacteria Ery-6A
            and Ery-6B and application in simulated water remediation
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 5246911)
  AUTHORS   Xu,S.
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2023) Zhejiang Agriculture and Forestry
            University, School of Environment and Resources, East Lake Campus of
            Zhejiang A&F University, Hangzhou City, Zhejiang Province, Hangzhou
            311300, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SOAPdenovo v. DEC-2022
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Reference-guided Assembly         :: HiFiasm/Unicycler/Flye
            Genome Coverage                   :: 181.0x
            Sequencing Technology             :: Illumina NovaSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_029339075.1-RS_2024_05_19
            Annotation Date                   :: 05/19/2024 05:09:14
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 4,739
            CDSs (total)                      :: 4,629
            Genes (coding)                    :: 4,609
            CDSs (with protein)               :: 4,609
            Genes (RNA)                       :: 110
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 89
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 20
            CDSs (without protein)            :: 20
            Pseudo Genes (ambiguous residues) :: 0 of 20
            Pseudo Genes (frameshifted)       :: 8 of 20
            Pseudo Genes (incomplete)         :: 12 of 20
            Pseudo Genes (internal stop)      :: 4 of 20
            Pseudo Genes (multiple problems)  :: 3 of 20
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 17:37:43
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 742213
            Orig. end                         :: 763281
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP120209.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..21068
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="3"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..21068
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21068
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11068](+)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11068
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     misc_feature    complement(510..524)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence:
                     strong, score: 23.97"
                     /tool="antismash"
     gene            653..2251
                     /locus_tag="PYS58_RS03380"
                     /old_locus_tag="PYS58_03380"
     CDS             653..2251
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:TIGR04183.1"
                     /locus_tag="PYS58_RS03380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PYS58_03380"
                     /product="T9SS type A sorting domain-containing protein"
                     /protein_id="WP_276284514.1"
                     /transl_table=11
                     /translation="MKFNYKKAIPVLAGVFFSGFMMAQTPAIQWQSSFGGANTEEASDI
                     IQTTDGGYLIAGSSDSTTGQVTGNHGFMDYWLVKLNSTGNMQWQRSFGGFAEDRASSVI
                     QTTDGGFIVAGTSYSTNGDVMGNHGNSDIWITKLNSDAGVIEWQKSLGGTNYETASKII
                     QTADGGYIVCGSSNSTNGDVTGNHGAFDFWIVKLSSTGNIQWQKSFGGPSDDTASSIIQ
                     TADGDYVVAGSSSSNGGNVTGNHGVKDFWILKLNADGGVIYWQKSFGGSHVEELNSMIK
                     TSDGGYIMIGSAYSNDGDITGSIGGTDYWIVKLNSTGNLQWEKSLGGTKVDIASSIVQT
                     SDGGYMVVGSSNSNDGQVTGYHPPVTGPGEGPNYYDYWAVKLNSTGSIQWQKALGGSGI
                     DNGNSVIQTADGGFVIAGDSNSNNGDVTGNHGGRDYWIVKLAPENLATSEIMKDVSVTA
                     NVYPNPAKEYITVKLDYFTPSMEASITDMLGKTVHQQKLEGLKTKINTSHLEKGVYFLN
                     VTGGRQKITKKFIKE"
     gene            complement(2335..3138)
                     /locus_tag="PYS58_RS03385"
                     /old_locus_tag="PYS58_03385"
     CDS             complement(2335..3138)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_KR (8-174). E-value: 6.1e-17. Score:
                     54.0. Matches aSDomain:
                     nrpspksdomains_PYS58_RS03385_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009091598.1"
                     /locus_tag="PYS58_RS03385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PYS58_03385"
                     /product="SDR family oxidoreductase"
                     /protein_id="WP_276284515.1"
                     /sec_met_domain="adh_short (E-value: 2.3e-32, bitscore:
                     110.5, seeds: 230, tool: rule-based-clusters)"
                     /sec_met_domain="Polysacc_synt_2 (E-value: 1.3e-05,
                     bitscore: 22.5, seeds: 77, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSNYYNDKVVWITGASSGIGEALVRELVQNSNVKVILSSRNEEQL
                     YEVAESAGLSVNRYTVIPLDLKNYKEMPEIAAKAIAAFGKIDILINNAGLSQRSLAMDT
                     DIEVDKRLMDVDFIGTVALTKATVPYMIRNKGGQIAVVSSLMGIFGAPMRSGYAAAKHA
                     LHGFFDALRAELYAQNISITIICPGFIQTNISIHAVTGDGSLQGTMDNATHNGMPVDVF
                     AKKMLNAIEKKKNQKAIGGKEVLGVYLKRFFPSLLAKIIRKAKVV"
     aSDomain        complement(2617..3114)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_PYS58_RS03385_PKS_KR.1"
                     /evalue="6.10E-17"
                     /label="PYS58_RS03385_PKS_KR.1"
                     /locus_tag="PYS58_RS03385"
                     /protein_end="174"
                     /protein_start="8"
                     /score="54.0"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="VVWITGASSGIGEALVRELVQNSNVKVILSSRNEEQLYEVAESAG
                     LSVNRYTVIPLDLKNYKEMPEIAAKAIAAFGKIDILINNAGLSQRSLAMDTDIEVDKRL
                     MDVDFIGTVALTKATVPYMIRNKGGQIAVVSSLMGIFGAPMRSGYAAAKHALHGFFDAL
                     RAE"
     CDS_motif       complement(3016..3114)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_PYS58_RS03385_0001"
                     /evalue="7.30E-08"
                     /label="PKSI-KR_m1"
                     /locus_tag="PYS58_RS03385"
                     /protein_end="41"
                     /protein_start="8"
                     /score="25.1"
                     /tool="antismash"
                     /translation="VVWITGASSGIGEALVRELVQNSNVKVILSSRN"
     gene            complement(3160..4827)
                     /locus_tag="PYS58_RS03390"
                     /old_locus_tag="PYS58_03390"
     CDS             complement(3160..4827)
                     /GO_function="GO:0016627 - oxidoreductase activity, acting
                     on the CH-CH group of donors [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009091600.1"
                     /locus_tag="PYS58_RS03390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PYS58_03390"
                     /product="FAD-binding dehydrogenase"
                     /protein_id="WP_276284516.1"
                     /transl_table=11
                     /translation="MEETFQPDAIIIGTGLAGLTAAMEITNAGKKVLLLDQETEQNIGG
                     QAFWSFGGLFLINSPQQRRMGIKDSYELALQDWKGTAGFDRDEDYWPRKWAEAYLKFAA
                     GEKYKYISKLGIKLMFMVGWAERGDGSANGHGNSVPRFHVSWGTGTGVIKPFVEKAYQA
                     KEKGMLQMKFRHRVTELTVKNGKVTGLKGDILENDDQERGVATNRNIISSFEYSAPHII
                     IASGGIGANHELVRKNWPERLGTPPENMVCGVPAYVDGKMIGIAENAGANIINRDRMWH
                     YTEGLQNWKPIWPNHGIRILPGPSSLWFDAKGKRLPAPFLPGFDTLGTLKYIQDTGYSY
                     SWFILTQKIIKKEFALSGSEQNPDITNKDYSLFLKRILGKKAPGPVEAFKEHGKDFIVS
                     DNLKDLVEKMNQLAGNNLLKYDKIKSQIEARDRELDNKFSKDTQVNYIRSTRSYLGDKL
                     GRVAAPHKILSPENGPLIAVRLNILTRKTLGGIKTNLNGQVLKEDDSLIEGLYAAGEVA
                     GFGGGGMHGYRALEGTFLGGCIFSGMKVGKYIAGLKKE"
     misc_feature    complement(4811..4825)
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 19.13"
                     /tool="antismash"
     gene            5164..5919
                     /locus_tag="PYS58_RS03395"
                     /old_locus_tag="PYS58_03395"
     CDS             5164..5919
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="PYS58_RS03395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="PYS58_03395"
                     /product="hypothetical protein"
                     /protein_id="WP_276284517.1"
                     /transl_table=11
                     /translation="MIIPNRTIKNIVIPDIEQMNIQSQKEDSIQSKNILGKSRKIKRFQ
                     KNIIDHSSYSLEEYGDEGPIRKATIKNSKLRVLDEVFMNKKNVITINEEWTNYKDSLFY
                     PKIDYNYTFYETGNLKKIKCYSSYIPVGNWYLYDETGKELHHINIDKHFKMSLIQILEK
                     ASKIKIDNHPGYSIARLFDDKHSYWKLKYSELSDEQAGPPVVILIDDSTGKIIYKESQN
                     HEPDYRNSGIIDYKSIFNYMQKIFKPFGE"
     gene            6041..6799
                     /locus_tag="PYS58_RS03400"
                     /old_locus_tag="PYS58_03400"
     CDS             6041..6799
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="PYS58_RS03400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="PYS58_03400"
                     /product="hypothetical protein"
                     /protein_id="WP_276284518.1"
                     /transl_table=11
                     /translation="MIIPNRTIKNIVIPDIEQMNIQSQKEDSIQSKNSWGENRKIKRVI
                     KNTVNNSNYSLEENDSEGLIRKLAIENSNLRTFDEVFRDKRNVIIINKEWTDYKDKPIY
                     LTIDYHYAFYETGILKKIKCYSSYIPVGNWYLYDETGKELHHINIDKHFKMSLIQILEK
                     ASKIKIYNHQSYSIARLFDAKHSYWKLEYFKSSDEHQAGPSIVILIDDSTGKIIYKESQ
                     NHEPDYKSSGIIDYKSIFNYMQKNFKPFSE"
     gene            complement(6827..7933)
                     /locus_tag="PYS58_RS03405"
                     /old_locus_tag="PYS58_03405"
     CDS             complement(6827..7933)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="PYS58_RS03405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="PYS58_03405"
                     /product="hypothetical protein"
                     /protein_id="WP_276284519.1"
                     /transl_table=11
                     /translation="MKINPPEHWINFLKVFTKKYNEDIIYDVVRVLRTVEDLQERYDTY
                     EFEEFLPEYIPVADDSGGQVAVISKNNKDTKVYLSSYGVLQKETLEVLDRDLIHWMQRK
                     FPFDREQNIISSEEIEKMKEQNASLLQKIYSFPVIIEFLKTAVLIEGLALPENYASAEH
                     IYYFQDGYHYNSAENKLLAGNAPGEFQSSWIVLASNYFADPFFIDLNEAEADFPVYFAY
                     HGQGNWAPIKVAESLSIFQKILQEIQNLRWDKAELIEYFDENIDLENPLWEEVYTSIEE
                     EEEGVSNSIETYEAMGSEVNLYITDIGPNKMKVIALLKKEFGLSGAEALQLSKEPKILF
                     RTGYTKWLEYDRKQLEDLGAKVEYEDLN"
     gene            8396..8824
                     /locus_tag="PYS58_RS03410"
                     /old_locus_tag="PYS58_03410"
     CDS             8396..8824
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002979378.1"
                     /locus_tag="PYS58_RS03410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PYS58_03410"
                     /product="rhodanese-like domain-containing protein"
                     /protein_id="WP_185247457.1"
                     /transl_table=11
                     /translation="MKYLFMVACLFCSLFSQAQQTQNPWKESQLMDPALLASRIVKHKT
                     KDLIIISVGPEAIIKGSVDIGPTHEPENLEKLKNYLKDIPKNKEIVIYCGCCPFVKCPN
                     IRPAFHLLMEMGFKNSQLLNLPKNIKTDWLDKDYPTND"
     gene            8826..9320
                     /locus_tag="PYS58_RS03415"
                     /old_locus_tag="PYS58_03415"
     CDS             8826..9320
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1241: lipoprotein
                     dsbF"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002979377.1"
                     /locus_tag="PYS58_RS03415"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PYS58_03415"
                     /product="TlpA disulfide reductase family protein"
                     /protein_id="WP_276284520.1"
                     /transl_table=11
                     /translation="MKTSFTVMFLILFSGFAFAQNKIEIGKKAPEIIMAKPDGSSFSLS
                     SQKGKLVLIDFWATWCAPCVEEQPELKKLYDIYSNQVKANKFEILGVSLDKNKESWQKA
                     IDRFNINWIQISDLKFWKSPVAKTYEIDELPFNVIIDGEGTIIAKNLHEKELEEFLRNS
                     L"
     gene            10001..11068
                     /locus_tag="PYS58_RS03420"
                     /old_locus_tag="PYS58_03420"
     CDS             10001..11068
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF040195.3"
                     /locus_tag="PYS58_RS03420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PYS58_03420"
                     /product="hypothetical protein"
                     /protein_id="WP_276284521.1"
                     /sec_met_domain="T1TS (E-value: 1.3e-32, bitscore: 111.9,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNSIIHKLPLPGIKKTESAIQDSMGWLKKYQLISDEHQAEHIANA
                     GAYFTALSFPDIKHYQIRDVTDFCSWVCLLDDVGEELLLHSSLPQLINFFSGLKYICEE
                     PDYQNPNHPGLFYEHPMINAFLDLKSRLSNWAGIPQINSLMKAVGGFANGIQWENAFKI
                     ENKHPDLSTFCAMRMTSGGMEIPSALAQCVNKVQLSTIELTNPVILILTKSICFVGLLD
                     NDIYSYEKEKASDVYYNNIIQIYLISYPYLSEEQAISKAIDLRNQILFLYHLLKQKYHY
                     IYEPIALYFKGLEDVISGNLIFCSTNKRYKVANDRKGHDFTIVKNGKQDINPPKDITSI
                     SWWWSLLDTQYSFKN"
     gene            11161..11556
                     /locus_tag="PYS58_RS03425"
                     /old_locus_tag="PYS58_03425"
     CDS             11161..11556
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016200179.1"
                     /locus_tag="PYS58_RS03425"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PYS58_03425"
                     /product="DoxX family protein"
                     /protein_id="WP_185269431.1"
                     /transl_table=11
                     /translation="MKKNYFLRCALSIILLMHSVISIFSGDVNSFGINYLDTIGFYPIG
                     LYLAWTVKLIHLVSVFLLWTDRYIKPVALCNILIFVFGIYYIHWESGWYVVGGGTNGIE
                     FNILLIFSFINLIFPEVVLKKKTNRSL"
     gene            11626..12711
                     /locus_tag="PYS58_RS03430"
                     /old_locus_tag="PYS58_03430"
     CDS             11626..12711
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0000155 - phosphorelay sensor kinase
                     activity [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007839750.1"
                     /locus_tag="PYS58_RS03430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PYS58_03430"
                     /product="histidine kinase"
                     /protein_id="WP_276284522.1"
                     /transl_table=11
                     /translation="MITSLKPDHQSKLHIHLLFWILYYILEAYLDFYWSRYQFPDFMWQ
                     TRLQNTLILELGYFLVKIPLAYSLLYVYEKVHLNKVIKYMICILIIILAVLGHRLFTHY
                     IIYPYIYGVTETLDGKQPSGFINGLVAFNSFMDLIFMVGLVFGIEITRQKNLLKEQISQ
                     LKSEKLDQELTMLKAQINPHFLFNTLNNIYGMALKKADETPDVILQLSKIMRYNIYEAA
                     EKMISIGKDLENIKDFIQIQKIRHHHLSVHLRENIDNPSQEISPLILIQFVENAFKHGV
                     SESLGNSFITIDVELKNGILIYCIENSKEERPHQHSTKIGLKNIRRQLELLYPKHQLNV
                     EDKTGQYIVQLKIDFNDTPNH"
     gene            12692..13393
                     /locus_tag="PYS58_RS03435"
                     /old_locus_tag="PYS58_03435"
     CDS             12692..13393
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007839748.1"
                     /locus_tag="PYS58_RS03435"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PYS58_03435"
                     /product="LytTR family DNA-binding domain-containing
                     protein"
                     /protein_id="WP_276284523.1"
                     /transl_table=11
                     /translation="MIHPITKKYNCIIVEDEPIAAEILETFISRDAELNLIGKCSDAVH
                     ASNLLSIHEVDLMFLDLHLPVVKGFDFLKKLKNPPFVIVTTAYHQYAIEGYELDIADYL
                     LKPIPYERFTTAVGKFKYLMEAEDALLEMAERDHIFISSGKKQIKIILHDIFYIESLRE
                     YIHIHTKTETFTFKMPISKIEESLNPNMFTRIHKSYIISKPKIEIKSATVVQVKGKKLP
                     IGRTYKPFIDW"
     misc_feature    complement(13475..13489)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence:
                     medium, score: 22.76"
                     /tool="antismash"
     gene            13678..16701
                     /locus_tag="PYS58_RS03440"
                     /old_locus_tag="PYS58_03440"
     CDS             13678..16701
                     /GO_component="GO:0009279 - cell outer membrane [Evidence
                     IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0071702 - organic substance transport
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1082:
                     TonB-dependent siderophore receptor family"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007839746.1"
                     /locus_tag="PYS58_RS03440"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PYS58_03440"
                     /product="SusC/RagA family TonB-linked outer membrane
                     protein"
                     /protein_id="WP_276284524.1"
                     /transl_table=11
                     /translation="MKYQLKLLSAGVAFFIGSETYFSQDKQDSLKPQNIEGIVVTALGI
                     KRERKSLGYSTQEVKGEDINKNPTTNFLNNLSGKVAGLEIRQSTNFGGSIDAISRGYKS
                     ILGDNQALFVVDGVPIINRNINSTVQQNGFGGYDYGSPVSDINPNDIETVNVLKGAAAT
                     ALYGSRAQNGAIIITTKKGKKYTQGIGLEYSGSISVSTVDKSTFPEYQTQYGQGYLGNL
                     FPEYQNAPMAFFWHDASYGAPYDPNLMVWQYDAFIPGSQNFGKRTPWVMAKNGPITFFE
                     TAINQTNNVALSGGNDKATFRLSYSNTNATDIMPNSSLMKNNFGGNASYKITDKLTATI
                     FANYITQRTKGRNSTGYTDNIMTGFRQWWPTNVDIQYQKYLYETYNKNYTWNILGPDTL
                     FPAYWDNPYFSRYENYQNDRRDRFAGNFSLSYDVSKNINILGRVGIDGYTMITEERKAV
                     GSIPTFFSFNIIEQPSAYAVTNLRFTETNYDLIATYKKNITEDLNLQALLGGNVNVQSN
                     YSNAQTTTGGLYIPGLYTISNSVATPAKPITTDNTKYIYGAFVQASLGYKNTYYLEGTF
                     RRDQSTALPKAKQVYYYPSVSASVVFSNLLKQQWLSFGKIRAAYAEVGSDTNADQLRNR
                     YIPQASLENNPVYSYNTSLRNPDLFPQKLKNFEIGTNMQFFKNRVGLDLSWFRNIAFNQ
                     ILPLPISLATGSVSKIQNTGELTTKGVELTLNVTPLKSQHFTWDIAINWSNPKTKVTAL
                     REGIENITLGSLQGGITINAPLNEEYGSIWGADFVYDPNGNKIVGSNGAYLHTDDSNHN
                     LGSFQSDFVAGLNNSFTYKNFNLSFQIDWKKGGKVFSLDQYYGYGTGLYPDSVGLNDLG
                     NSIRNTLENGGGVILPGVMQDPNNPGHYIPNTIRLDRSMSSQTLETDPPVAAFVYDASF
                     IKLRQVSVSYTFNNQFLKKAGIQNLTLGLIGSNLWIIHKNLPYADPESGLSSGSIQGYQ
                     SGVMPATRNFAFNLKVNF"
     gene            16713..18149
                     /locus_tag="PYS58_RS03445"
                     /old_locus_tag="PYS58_03445"
     CDS             16713..18149
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007839744.1"
                     /locus_tag="PYS58_RS03445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PYS58_03445"
                     /product="SusD/RagB family nutrient-binding outer membrane
                     lipoprotein"
                     /protein_id="WP_276284525.1"
                     /transl_table=11
                     /translation="MKNMIISSLLALMLTNCTSDNVNDDPHVAYNMSPEPLLTYAEKEL
                     SDYMTTPSVNENNFRLTMQYWQEVTYVSESNYNFTARNVSNNVWIDNYVNVLNNLNKAK
                     ELIEQFQPPASEVNSWPAKKQNQLAIIDIISVYTFQTVVDTFGDIPYTQALNYEKYPLP
                     TYDDDAQIYEKLITRLKTDLNLLKEGEGTFGSGDIFYRGDIGKWKKFGNSLLLKLGIAL
                     SDVNPSLAQSTINTAISGGVIINETDNANFRYQEETPNFNPLFENLANSGRSDFFGGKP
                     FIDFLNATSDPRRAQYFKDVHGEYIGQVIGLPGIFSNFSAPGLFAYIPVTPGKILTNTE
                     VAFYLAEAAARFGIGGSPDVLYQNAVQASFVEWGFSAQDVQDYLSNHPYDAANWKKSIG
                     EQAWVAMYNHPVVSWNFYRRLDYPVLQAPPTAIANAGGKVPVRLQYPTLEATTNGTNYA
                     KAATAIGGDKLTTKVFWDVQ"
     gene            18394..18825
                     /locus_tag="PYS58_RS03450"
                     /old_locus_tag="PYS58_03450"
     CDS             18394..18825
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016198399.1"
                     /locus_tag="PYS58_RS03450"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PYS58_03450"
                     /product="hypothetical protein"
                     /protein_id="WP_276284526.1"
                     /transl_table=11
                     /translation="MKVNGIKKLMSGFIVMVIMGTLFFSCKNSDDNDEPTPISGQSIDP
                     VVGTFKGTIRIATQDYYNAIVVVSKVDATHIKVQPKSGEAYSVATPKVLSAVNPVGVGV
                     GGNDPEGSVNYLISTKALQISTKKTAATDVEFYYEGTKQ"
     gene            complement(18918..19235)
                     /locus_tag="PYS58_RS03455"
                     /old_locus_tag="PYS58_03455"
     CDS             complement(18918..19235)
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000539741.1"
                     /locus_tag="PYS58_RS03455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PYS58_03455"
                     /product="multidrug efflux SMR transporter"
                     /protein_id="WP_185247449.1"
                     /transl_table=11
                     /translation="MNWIALIIAGIFEIGWPLGLKLSQQPQSNKWSWIMFSIACMTVSG
                     AFLWYAQKSIPIGTAYAVWTGIGAVGTLLVGVLFFQDSASILRLLSALLIVVGIIGLKL
                     F"
     gene            19470..19970
                     /gene="mug"
                     /locus_tag="PYS58_RS03460"
                     /old_locus_tag="PYS58_03460"
     CDS             19470..19970
                     /EC_number="3.2.2.28"
                     /GO_function="GO:0000700 - mismatch base pair DNA
                     N-glycosylase activity [Evidence IEA]"
                     /GO_process="GO:0006285 - base-excision repair, AP site
                     formation [Evidence IEA]"
                     /codon_start=1
                     /gene="mug"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007839715.1"
                     /locus_tag="PYS58_RS03460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PYS58_03460"
                     /product="G/U mismatch-specific DNA glycosylase"
                     /protein_id="WP_276284527.1"
                     /transl_table=11
                     /translation="MLTDIISPHLDVIFCGINPGLKSSNDGHHFSGRSNRFWKVMHQSG
                     FTPYEIEAVNDTVILDFGCGLTTAVARATSRADELSKDEFDEALETFTTKITKFQPQYV
                     AFLGKAAYKAFSKKKEIQWGQQSEDFCGAKIWVLPNTSGLNRGFSLDDLVGYYKEFYQD
                     IHP"
     gene            complement(19977..20582)
                     /locus_tag="PYS58_RS03465"
                     /old_locus_tag="PYS58_03465"
     CDS             complement(19977..20582)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002979375.1"
                     /locus_tag="PYS58_RS03465"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PYS58_03465"
                     /product="DNA-3-methyladenine glycosylase"
                     /protein_id="WP_276284528.1"
                     /transl_table=11
                     /translation="MKLPLSYYSNQDVLFMAQDLLGKVLFTNIDGEITAGIIVETEAYH
                     GVSDKASHAYGGRRTDRTETLYNQGGISYVYLCYGIHHLFNVVTSVEDDPHAVLVRAVE
                     PLIGKEIMEMRRNMPASKAAISAGPGSAAKALGIDRSFNKKDLNGSDIWIEDHGIHYSS
                     DTIVAGPRIGVAYAQEDALLPWRFFVNGNKYVSKPNKI"
     misc_feature    complement(20881..20890)
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 15.96"
                     /tool="antismash"
ORIGIN
        1 acgctcggtc attgctgcat taatcgcata accgccaccc ccacagattc ctaatactcc
       61 gatacgtttt tcatctacat aaggcagaga cacaaggtaa tcgcaggcac aacggaagtc
      121 ttccactctt aaggtaggat cttcaatgaa acggatatct ccgccgctgg ctccctgaaa
      181 tgaagcatca aatgccaata ctacaaatcc tgcatccgcc aatgcctgtc cgtacacatt
      241 tccggaggtc tgctctttac agcttcctat tgggtgtgca ctgatgatgg ctgcatattt
      301 tttattttcg ttaaagttga gtgggaaata aagatctgct gctacgtccc agttaagatt
      361 tttgaatgtt actgactgaa tcataatact tattttttag tgattaacac tatgattatt
      421 ttatgataca aatgtacagt cagctatttt caaaagaggt agacatatta cctgaaaacg
      481 gatacatttt actgataaca gcgactttta attttctaaa tatttagaaa aaaaagcttt
      541 tcaggctact attcataagt aaaatgaaaa aaaaattaca acaacactaa aaaaatagaa
      601 ctttattctt atagaattta tatttttgca ctcctaaatt aaactaaaaa acatgaaatt
      661 caattacaaa aaagcgatcc ccgtattggc tggtgttttt ttttcaggct ttatgatggc
      721 acagactccg gctatacagt ggcaaagttc ttttggaggt gcaaataccg aagaagcaag
      781 tgatatcatt caaaccacag atggtggata tctgatcgct ggaagttccg attcaactac
      841 aggtcaggta accggtaatc atgggtttat ggattactgg ctcgtaaaat taaattcaac
      901 aggaaatatg caatggcaaa gatcttttgg aggatttgca gaggatagag ccagttctgt
      961 tattcagacg actgatggtg gatttatagt agccggaact tcatattcaa ccaatggaga
     1021 tgtgatggga aatcatggaa attccgatat ctggatcaca aaactaaact cagatgcagg
     1081 agttattgag tggcaaaagt ccttaggggg cacaaattat gaaacggcaa gtaaaattat
     1141 tcagacagca gatggtgggt atatagtttg tggaagctcc aattcaacca atggcgatgt
     1201 aacaggaaat catggagctt ttgatttttg gatcgtaaaa ctaagctcca caggaaatat
     1261 ccaatggcag aaatctttcg gaggaccttc agatgataca gccagttcaa ttattcaaac
     1321 ggctgacggt gattatgtag tggccggaag cagtagttca aacggtggaa acgtaactgg
     1381 aaaccatgga gtgaaagatt tttggatttt gaaattgaac gctgatggag gtgttattta
     1441 ttggcagaaa tcttttggcg gatcacatgt tgaagaatta aattccatga taaaaacctc
     1501 agacggcgga tatatcatga taggctcagc ttattctaat gatggagata ttaccggaag
     1561 tattggtgga actgattact ggattgtaaa attaaattct acaggaaatc ttcaatggga
     1621 aaaatctttg ggaggaacaa aagttgacat tgcatcatcc atcgttcaaa cgtctgatgg
     1681 aggctatatg gtggttggga gttccaattc aaatgatggc caggtaacag gatatcatcc
     1741 accagtaaca ggccctggag aaggtcctaa ttattatgat tattgggcag taaaattaaa
     1801 ttctacagga agtattcaat ggcaaaaagc cttaggagga tcaggaattg ataacggaaa
     1861 ttctgttatt caaactgctg acggtggttt tgttattgca ggggattcca attcaaataa
     1921 tggagatgtt acaggaaatc atggaggtag agattattgg atcgtaaaac ttgctcctga
     1981 gaatctggct acaagtgaga tcatgaaaga tgttagtgtt accgctaatg tttaccctaa
     2041 tccggcaaaa gaatatatta ctgtaaagct tgattatttt acaccttcca tggaagctag
     2101 cattacagat atgttaggaa aaacagttca tcaacaaaaa ttagaaggat tgaaaaccaa
     2161 gatcaataca agccatcttg aaaaaggagt ttattttttg aatgtgacag gtggtagaca
     2221 aaaaataacc aaaaaattca ttaaagaata attctatatc agatccaaga aaataaaacc
     2281 gtactttttg tgcggttttt ctgtattata tgagattatt ctttatcaaa accttcagac
     2341 tacttttgcc tttcggatta tctttgccag tagggaaggg aagaatcttt tcagataaac
     2401 gcccaatact tctttgccac caattgcttt ttgatttttc tttttttcga tagcattcag
     2461 catcttttta gcaaaaacat ctacaggcat tccgttatgg gtagcattat ccatcgttcc
     2521 ttgcaatgaa ccgtctccag ttaccgcatg aatggaaata ttggtttgta taaatcccgg
     2581 gcaaataatc gttatcgaaa tattttgagc atataattct gcacgcagcg catcaaaaaa
     2641 accatgaagg gcatgctttg cagcagcata tccactacgc attggggccc caaatattcc
     2701 cataagactt gaaacaacgg caatctgacc acctttattc cggatcatat aagggacagt
     2761 tgcttttgtt agagccactg ttcctataaa atcaacatcc attaagcgct tatccacttc
     2821 tatatccgta tccatagcca gagaacgttg ggacagtcct gcattattaa tcagaatatc
     2881 tatttttcca aaagctgcta tcgctttggc tgctatttca ggcatttcct tatagttctt
     2941 aagatctaaa ggaattacag tatatcggtt aacgctaagt ccggcacttt ctgccacttc
     3001 atagagctgt tcttcgtttc tggaagaaag aatcactttt acattgctat tttgaaccaa
     3061 ctctcttacc aaagcctcgc caattcctga tgatgcacct gtaatccaga caactttatc
     3121 attataataa ttgctcattt gaagttttat tagtttgaat tattcttttt ttagtcctgc
     3181 aatatatttt ccaactttca ttcccgaaaa aatacatcct ccaagaaatg tcccttctaa
     3241 tgcacgatac ccatgcattc cgccgccgcc aaagcctgcc acttctcctg ccgcataaag
     3301 tccttcgatg aggctgtcat cttcttttaa aacctgtccg ttcagattgg tttttatgcc
     3361 acccaatgtt tttcgggtta aaatattaag ccgtacggca atcaaaggtc cattttccgg
     3421 ggatagaatt ttatggggtg cagcaactct tccaagctta tctcccaaat aacttctggt
     3481 actccttata taattaacct gggtgtcttt tgaaaattta ttatccaatt ctctgtctct
     3541 ggcttctatc tgggatttta tcttgtcata ctttaaaaga ttgtttcctg ccagctgatt
     3601 cattttttcc accagatctt tcaaattatc agatacaatg aaatcttttc catgctcttt
     3661 aaaggcttct acaggaccag gagctttttt gcccaaaata cgtttcagaa aaagagaata
     3721 atctttattc gtaatatccg ggttctgttc tgaaccagag agtgcaaatt cctttttgat
     3781 aattttctga gtgaggataa accacgaata agaatatccg gtatcctgaa tatatttcaa
     3841 tgttcctaag gtatcaaatc caggcagaaa aggagcagga agacgctttc ctttagcatc
     3901 aaaccataga gaagaaggcc caggaagtat tcttatccca tgattaggcc agatgggctt
     3961 ccaattttgc agaccttctg tataatgcca cattctgtcg cgattgataa tattggcccc
     4021 tgcattttca gcaataccaa tcatttttcc atctacataa gcaggaactc cacaaaccat
     4081 attctccggg ggcgttccca atctttcggg ccagtttttc cttaccaatt catgattagc
     4141 gcctatacct cctgaggcaa tgataatatg gggtgccgaa tattcaaatg atgagattat
     4201 atttctatta gtggcaacgc ctctttcttg gtcatcattt tccagaatat cacctttcaa
     4261 acccgttact tttccattct ttacggtcag ttctgttact ctgtgccgga atttcatttg
     4321 cagcattcct ttttctttgg cctgatatgc tttttccaca aaaggtttta ttacccccgt
     4381 accggttccc cagcttacat gaaaacgagg aacagaattt ccgtgtccgt tggctgatcc
     4441 gtcaccgcgt tctgcccagc ctaccataaa catcagcttg attcccagct tggaaatgta
     4501 tttatatttt tcacctgctg cgaatttcag gtaagcttcg gcccattttc gtggccagta
     4561 atcttcatca cggtcaaaac cggcagtccc tttccaatct tgtaatgcca attcatagga
     4621 gtctttaatt cccattcttc gttgctgggg agaattaatc agaaaaagtc cgccaaatga
     4681 ccagaatgcc tgtccgccta tgttctgttc ggtttcctga tccagtaaca atactttttt
     4741 cccggcattg gtaatttcca tcgcagcagt aagtcctgcc aatccggttc ctatgataat
     4801 tgcatcaggc tggaatgttt cttccataga taaaggtgtt tttttattct caatacttta
     4861 tataaatgta taaaatattt gccttcaaaa tatgaaaccg gagcatgtaa aattattcat
     4921 gtcatatcta ctgttttaag cactgactat cagatgagac attatccact tttcaacact
     4981 atctttgtta ataattccgg attttatgtt ttcttttggt gatgttattt ttttatcaga
     5041 acttttccat gaataagtta aacaggtttt aatatgagaa aactaagcat tctattttta
     5101 atccttttta ttagtataat atactgtaat gcccagaaaa gaaagcatgc atctgataga
     5161 acaatgataa tacccaatcg taccattaaa aatatagtga ttcctgatat agagcaaatg
     5221 aatattcaat ctcaaaagga ggattcaata caatcaaaaa atatattagg gaaaagcaga
     5281 aaaattaaga gattccaaaa aaatataata gatcattcca gctattcttt ggaagaatat
     5341 ggtgatgaag gacctatcag aaaagcaacc ataaaaaact caaaactccg tgttcttgac
     5401 gaagttttca tgaataaaaa aaatgtgatc actatcaatg aagaatggac caattataag
     5461 gattctcttt tttatccaaa aatcgattat aattatacat tctatgaaac tggaaattta
     5521 aaaaaaataa agtgctattc tagttatatc ccggtaggaa attggtattt atatgatgaa
     5581 accggaaaag aacttcacca tattaatata gataagcatt tcaaaatgtc acttattcag
     5641 attctggaaa aagcatctaa aataaagata gacaatcacc caggttattc tatcgccaga
     5701 ttatttgatg acaaacactc gtactggaaa ttaaaatatt ctgaattaag tgatgaacaa
     5761 gcaggacctc cagtcgtaat tttaatagat gacagtacag gaaaaattat ttataaggaa
     5821 tcacaaaatc acgagcctga ttacagaaac tcagggatta ttgattataa atccattttt
     5881 aattacatgc aaaaaatttt taagcctttc ggtgaataaa ttaaacaggt tttaatattt
     5941 aatataagca atgagaaaac taagcattct atttttaatc ctttttattg gtgtaatata
     6001 ctgtaatgca cagaaaaaaa agcatgcatc tgataaaaca atgataatac ccaatcgtac
     6061 cattaaaaat atagtgattc ctgatataga gcaaatgaat attcaatctc agaaagagga
     6121 ttctatacaa tcaaaaaatt catggggaga aaatagaaaa attaaaagag tcattaagaa
     6181 tactgtaaac aactcaaact attctttaga agaaaatgat tctgaagggc ttatcagaaa
     6241 attggccata gaaaactcaa atcttcgtac ttttgatgaa gttttcagag ataaaagaaa
     6301 tgtaatcatc atcaataaag aatggaccga ctataaggat aaacccattt accttactat
     6361 cgattatcat tatgcattct atgaaactgg aattttaaaa aaaataaagt gctattctag
     6421 ttatatcccg gtaggaaatt ggtatttata tgatgaaacc ggaaaagagc ttcaccatat
     6481 taatatagat aagcatttca aaatgtcact tattcagatt ctggaaaaag catctaaaat
     6541 aaagatatat aatcaccaaa gttattctat cgccagatta tttgatgcca aacactcata
     6601 ctggaaatta gagtatttta aatcaagtga tgagcatcag gcaggacctt caatcgtaat
     6661 tttaatagat gatagtaccg gaaaaattat ttataaggaa tcacaaaatc acgagcctga
     6721 ttacaaaagc tcaggaatta ttgattataa atccattttt aattacatgc aaaaaaattt
     6781 taaacctttc agtgaataga gaaaaataca aatctttgaa tatcttttaa tttaaatctt
     6841 catattcaac cttagctcca aggtcttcca attgcttacg atcatattcc aaccatttag
     6901 tatacccagt tctaaacaat atttttggtt ctttactgag ttgaagagct tctgctccgg
     6961 aaagaccgaa ttcttttttc agtaatgcaa taaccttcat tttattgggc ccaatatcgg
     7021 taatgtacaa gtttacttct gaacccattg cttcataagt ttctattgag ttcgaaacac
     7081 cttcttcttc ctcttcaata ctagtatata cttcttccca taaaggattt tcaaggtcta
     7141 tattttcatc aaaatattca attaattcag ctttatccca tcttagattt tgaatctcct
     7201 gcagtatttt ctgaaaaata cttaaacttt cagctacttt aataggggcc cagtttccct
     7261 gtccatgata agcgaaataa acaggaaaat cagcttcagc ttcattcaaa tcaataaaaa
     7321 aaggatcagc aaaataattg gaagccaaaa caatccagct tgactgaaat tctccgggag
     7381 cattacctgc caggagttta ttctctgccg aattatagtg atatccatcc tgaaagtaat
     7441 aaatatgctc tgcagaagca taattttccg gcaaagcaag tccttctata agaacagctg
     7501 ttttcaaaaa ttctataata acagggaatg aataaatttt ttgaagtaaa gaagcgtttt
     7561 gttctttcat tttttcaatt tcttcagagg atatgatatt ttgttctctg tcaaaaggaa
     7621 actttctctg catccagtgt attaaatcac ggtctaaaac ctccagagtt tccttctgaa
     7681 gcacaccata ggaactcaga tacacttttg tatctttatt attttttgaa ataacggcaa
     7741 cctgaccgcc agaatcatct gcaacaggaa tatattccgg aagaaattct tcaaattcat
     7801 aagtatcata acgttcctga agatcttcta cagtacgtaa tacacgaaca acatcataaa
     7861 tgatgtcttc gttatatttt ttagtaaaaa cttttaaaaa atttatccaa tgttcaggag
     7921 gattgatttt catagcataa agcgcatatt tattttaagt attaagagga tggggtttgc
     7981 tttaaatatg ataaagtaaa gtaatttgat ttcatctact tttcttaata actttatcat
     8041 tcttaatgat tttgaaattt tttatttaaa tataaagggg tactttaaag caacccgaag
     8101 tcatagctga tatccggcta taatttgttt ttcacgacta aaatacaaaa agcagattca
     8161 tttgaagttt tatctttgtt aaaaatcatc acaatgagag aatataaacc ctaggacgtg
     8221 aacaggagag gagttcggga gtcaggttaa ttattgagcc tggagcagcg aatgtcattt
     8281 atctcactcc aaaaaagaat taatatcctt taaaacatca gtaataatgt aaaaacaccc
     8341 tccatactcc ttttaagatt caacaaatcc tttatatatt tgtgaaaaaa gaagtatgaa
     8401 gtatttgttt atggtagcct gcttgttctg ctcccttttc agtcaggcac agcagacaca
     8461 gaatccatgg aaagaaagcc agctaatgga tcccgcatta ttagcctcaa gaattgtaaa
     8521 gcacaaaact aaagatttaa taatcatttc agtaggacct gaagcgatta ttaaaggttc
     8581 tgtggatata ggaccaactc atgagccgga aaatctggaa aagctgaaaa attatcttaa
     8641 agatattcct aaaaataagg aaattgtgat ttattgtgga tgctgtcctt tcgtaaaatg
     8701 tccgaatatc cgtcctgcat ttcatctatt gatggaaatg ggctttaaaa acagccagct
     8761 tttaaatctt cctaaaaata taaaaacgga ttggctggat aaagattatc caacaaatga
     8821 ttaatatgaa aacaagtttt actgtaatgt ttctaatcct gttttcggga tttgcattcg
     8881 ctcaaaataa gatcgaaata ggaaagaagg caccggaaat aataatggct aaaccagatg
     8941 gatcttcatt ttctctttcg agtcaaaaag gaaagcttgt ccttattgat ttttgggcta
     9001 cctggtgtgc tccatgtgta gaggagcaac ctgagttgaa aaaactgtat gatatctatt
     9061 cgaatcaggt aaaagctaat aaatttgaaa ttttgggggt ttctttagat aaaaataaag
     9121 agagctggca gaaagctatt gatcggttta atatcaactg gatacaaatc agtgatttaa
     9181 aattctggaa aagccctgtt gcaaaaactt atgaaataga tgaacttcca ttcaatgtta
     9241 ttattgacgg tgaaggaacg attatcgcta aaaatcttca tgaaaaggaa cttgaggagt
     9301 ttttaaggaa cagcttataa taaaaaagag taagatcgaa aaaaacaacg atacaaaaga
     9361 gtggtcaggg tggccactct ttttgagttt aacagctatt tgtgcattag aatcggtgct
     9421 gaattttgtg cttgtcatca atcagaaaat gatagaggga aaatcattgt cgattgatga
     9481 ttttttttca gtcaagtttc attaatctcg taattaatac tataaaaata agaattaaat
     9541 ttataaaaat cacaataaag ggaataattt aaatgttaat ttttacattc agttaagtaa
     9601 caattactta ataaatattt gttggtgatt caaaataata tcttatttaa tttatactca
     9661 gaattaaaca aaaatattta tcaatattat aaatatacac atttttatca ttatatattt
     9721 aaaaaaaata caatattgaa ataattatac aaacaataaa taattattgc taactattta
     9781 ttacctttaa gtataatatt aaagaaaata ataacaataa gaaaacttcc ttcatcatac
     9841 aaaattccac ttccaggcta ttgttcacaa tcatacaatc tattctggta ttgaaatatt
     9901 acattctaca atattattat ctcgatggct ttttgaagga atagacgaga ttattatcaa
     9961 acagtatact acacaaaaac acctaatcaa ataaaatagt atgaattcaa tcatccacaa
    10021 actcccatta ccgggaatta aaaaaacgga atcagctatc caggattcta tgggctggct
    10081 taaaaagtat caattaatat cagatgaaca tcaggcagaa catattgcca acgccggtgc
    10141 ctattttacg gcattgagtt tcccagatat taagcattat cagataaggg atgttacgga
    10201 tttttgctcc tgggtgtgtc ttttagatga tgtaggagaa gaactgcttc tccatagcag
    10261 tcttcctcaa ttaatcaact ttttttcagg tttaaaatac atctgtgaag aaccggatta
    10321 ccaaaatcct aatcatcctg gactctttta tgaacatccg atgatcaatg catttttgga
    10381 ccttaaatcc agattaagca attgggccgg aattccgcaa atcaattctc tgatgaaagc
    10441 ggttggaggt tttgctaatg gaatacagtg ggaaaatgcc tttaaaattg aaaacaagca
    10501 tccagatctt agtacttttt gtgccatgag aatgacaagt ggaggaatgg aaattccttc
    10561 tgctttggcg caatgtgtaa acaaagtaca actaagcaca atagaactta caaatccggt
    10621 tatcctgatt ttaacgaaga gtatttgttt tgtagggctt ctcgataatg atatttattc
    10681 atacgaaaaa gagaaggctt ctgatgtcta ctataataat atcattcaga tttatcttat
    10741 ttcttatccg tacctgagtg aagaacaggc tatatccaag gcaatagatc tgcggaacca
    10801 aattctattt ttgtatcatt tattgaagca aaaataccat tatatctacg aacccattgc
    10861 tttatatttc aagggactgg aagatgttat ttcaggaaac ctcatttttt gcagtactaa
    10921 taagcgatat aaagtagcca atgacaggaa gggccatgat ttcacaatcg tcaagaacgg
    10981 taaacaagac attaaccctc caaaagatat tacttccatt tcatggtggt ggtctctact
    11041 ggatactcaa tattccttta agaattaata tctgctgata aaaaaaaatt catatacact
    11101 taagagtcat taatatacat ctgaatacgc catacaatcc tgatgtttac ttttgattct
    11161 atgaaaaaga actacttcct ccgatgtgct ttgtctatca tcttattgat gcatagcgta
    11221 atctccattt ttagtggtga tgtcaatagt tttggtatca actatcttga taccatagga
    11281 ttttatccaa taggactgta tcttgcctgg actgtaaaac ttattcatct tgtttctgtt
    11341 ttccttcttt ggacagaccg gtatataaag cccgttgccc tctgtaatat cctgatcttt
    11401 gttttcggga tctattatat tcactgggaa agtggctggt atgtagtagg tggtggaacc
    11461 aatggtattg agtttaatat tttgctgata ttcagtttta ttaatcttat atttcctgaa
    11521 gttgtcctga aaaagaaaac aaaccgcagt ttatagatca atggctgaaa ttgatagact
    11581 ttatattcct atatttaact gaatcttatt attttatatt tttaaatgat aacaagtttg
    11641 aaaccggatc atcaatctaa gctccacatt catctgcttt tttggatact gtactatatt
    11701 ctggaagcct acctggattt ctattggtcc agataccagt ttcctgattt catgtggcag
    11761 accagacttc agaatactct tattcttgaa ttggggtact ttttagttaa aattcctctt
    11821 gcttattcat tactatatgt atatgaaaag gttcatctta acaaggttat caaatatatg
    11881 atctgtattc tgatcatcat ccttgcggtt ttagggcatc ggttattcac tcattatatt
    11941 atttacccat atatctatgg ggttacagag actttagatg gtaagcagcc ttccggattt
    12001 atcaatggtt tagtagcatt taattctttt atggatctta tttttatggt aggactggtt
    12061 ttcggaatcg aaattacgcg gcagaaaaat ctgctgaaag agcagatttc tcaattgaaa
    12121 tcagaaaaac tggatcagga acttacgatg ttaaaagctc agatcaatcc gcattttttg
    12181 tttaatacac tgaacaacat ctacggaatg gcccttaaaa aggcagatga aacgcctgat
    12241 gtaattctgc agctttctaa aatcatgagg tataatatct atgaagcggc tgaaaaaatg
    12301 atttccattg gaaaggacct tgaaaatatc aaagatttta tacagattca gaaaataagg
    12361 catcatcatc tcagtgtaca tttacgggaa aatattgata atccttctca ggaaatttca
    12421 ccactgatcc tgatacagtt tgttgaaaat gcttttaaac atggtgtttc tgaaagtttg
    12481 ggaaattctt ttatcaccat tgatgttgaa ctgaaaaacg gaattcttat ctattgtatt
    12541 gaaaattcca aagaagaaag acctcatcag cattctacaa aaataggact gaaaaatatc
    12601 cgtcggcaac ttgagctgct ttaccctaaa caccaactca atgtagagga taaaactggc
    12661 caatatattg tgcaactcaa aattgatttc aatgatacac ccaatcacta aaaaatacaa
    12721 ttgcattatt gtagaggacg aacctattgc cgcagaaatc ctggaaactt ttatttcccg
    12781 tgatgctgaa ctcaatctta taggaaaatg ttccgatgct gtacatgcaa gcaatctttt
    12841 aagcattcat gaagtagatc ttatgttttt ggaccttcac cttcctgtgg tgaaaggctt
    12901 tgattttttg aaaaaactaa aaaatccgcc atttgtaatt gttactacag cgtatcatca
    12961 gtatgccata gaaggatatg aactggatat tgcagattat ctactgaagc ctattcctta
    13021 tgaacgcttt actactgctg ttggtaagtt taaatattta atggaagcgg aagatgcttt
    13081 actggaaatg gctgagcgtg accatatttt catcagcagt ggcaaaaaac agattaagat
    13141 tattcttcat gatattttct atattgaaag tttaagagaa tacattcata ttcataccaa
    13201 gacagaaact ttcactttta aaatgcccat cagtaaaata gaggagagtc tgaacccaaa
    13261 tatgtttacc cgcattcata aatcttatat tatttccaag cctaaaatag agattaaatc
    13321 cgcaactgtt gtacaggtaa aagggaagaa acttccgatt ggcagaactt ataaaccgtt
    13381 tattgattgg taatattata accacccgtc aaaaattcaa ataatttttg acaccactcc
    13441 ggaagagggg gagtatttaa tccttcaatg ctaatatttt gtgaaaattt acaattttca
    13501 caaaaacaga aaggttttaa aaccttcatg actttccatt aaaaaaataa acgaaataat
    13561 ttccgccatt cattagtcac attttagtag actccattcc gccattcata tatacaatac
    13621 attgtattcc tcaccaatta ttgaattttg attacacaat aaacaaaatc aataattatg
    13681 aaataccagt tgaagctttt aagtgcaggt gttgcttttt ttatcggaag tgaaacctat
    13741 ttcagccagg acaagcaaga ctccctcaag cctcagaata tcgaagggat tgttgttact
    13801 gcactaggga tcaaaagaga aagaaaatct ctgggatatt ctacacagga agtaaaagga
    13861 gaggatatca acaaaaatcc tacaaccaat ttcctgaata atttgtccgg aaaggtagca
    13921 gggcttgaga tcaggcagtc taccaacttt ggcggttcca tagatgccat ttcaaggggg
    13981 tataaatcta ttttaggaga taaccaggct ctttttgtgg tggatggggt tcccattatc
    14041 aacaggaata ttaactccac agttcagcag aacggatttg gtgggtatga ttacggaagt
    14101 cctgtttcag atatcaatcc caatgatatt gaaaccgtga atgtattaaa aggagccgct
    14161 gcaactgctt tatacgggtc aagagctcaa aatggtgcga ttatcattac cacaaaaaaa
    14221 ggaaagaaat atacacaggg tatcgggctg gaatatagtg gaagcattag tgtatctacc
    14281 gttgataaat ctaccttccc ggaataccag acccaatatg gacaaggata tctcggaaat
    14341 ctttttccgg aataccagaa tgctcccatg gccttcttct ggcatgatgc ttcatacgga
    14401 gcaccctatg atccgaatct tatggtatgg cagtatgatg ctttcatccc aggctcccag
    14461 aatttcggaa agagaacacc atgggtaatg gccaaaaacg ggccgatcac tttttttgaa
    14521 acagcaatta atcaaaccaa taatgttgct ttgagcggcg gaaatgacaa agcaactttc
    14581 cgattaagct attctaatac caatgccacg gacattatgc ctaattcttc tttaatgaaa
    14641 aacaattttg gcggaaatgc atcctacaag attaccgata agcttacggc cactattttt
    14701 gccaactata ttacacagag aaccaaagga cgaaattcaa caggatatac cgataatatt
    14761 atgacggggt tccgccagtg gtggcccacc aatgtagata ttcaatatca gaaatacctt
    14821 tatgaaacct acaataaaaa ttatacatgg aatatcttag gacctgatac tctttttcct
    14881 gcctattggg ataaccctta tttctccaga tatgaaaatt atcagaatga cagaagagat
    14941 cgttttgcag gaaacttcag tctgagctat gatgtttcca aaaacatcaa tatccttgga
    15001 agagtaggta ttgacggcta tacaatgatt accgaagaaa gaaaagcagt aggttctatc
    15061 cctacattct tcagttttaa tattatagaa cagccttcag cctatgcagt aaccaatctc
    15121 cgttttacgg aaaccaatta cgatctgatt gctacttata aaaaaaatat taccgaagac
    15181 ttaaatctac aggctttact gggtggaaat gttaatgttc agtcaaacta ttccaatgcg
    15241 cagacaacaa ccggcggatt atatattccg ggactttata cgatttccaa ttcagttgct
    15301 actcctgcca aacctattac aacagataat accaaatata tttacggggc ttttgttcag
    15361 gcttctttag gatataaaaa cacctattac ctggaaggaa cgttcagaag ggatcagtct
    15421 acggctctgc ctaaagcaaa acaggtctat tattaccctt cggtttctgc cagtgtagta
    15481 ttctccaatc tattgaaaca acaatggtta agtttcggaa agataagagc agcttatgct
    15541 gaagtaggtt cggacaccaa tgcagatcaa ttaagaaaca ggtatattcc acaggcctct
    15601 ttggaaaata atcctgttta ctcctacaat acctctttaa gaaatccaga tctctttccg
    15661 caaaaactga aaaattttga gatagggacc aatatgcagt tttttaaaaa cagggtaggc
    15721 ttagaccttt catggttcag gaatattgca tttaatcaga tattaccact tcccatttcc
    15781 ctggcaacgg gctcagtttc aaaaatacag aatacaggag agcttactac aaaaggagtg
    15841 gaacttactt taaatgtaac gccattgaaa tcacagcatt ttacgtggga tatagccatt
    15901 aactggtcta atccaaaaac taaagtaacg gcccttcggg aaggtataga aaatattaca
    15961 ctaggttcgt tacaaggtgg tatcaccatt aatgctcctc tcaatgaaga atatggaagc
    16021 atttggggag ctgactttgt ttatgatccc aatggaaata aaattgtagg gagcaatggc
    16081 gcttacctgc atacggatga cagcaatcat aaccttggaa gctttcagtc tgattttgtg
    16141 gcaggcctta ataattcttt tacctataaa aattttaacc taagttttca gatcgattgg
    16201 aaaaagggag gaaaagtatt ttccctggat cagtattacg gttacggaac aggtctttat
    16261 ccggattctg taggcttgaa tgatctcgga aattccatca gaaatactct ggaaaacgga
    16321 ggtggtgtta ttttaccggg ggtaatgcag gatcctaata atccggggca ttatattccc
    16381 aacacgattc gcttagaccg ttcaatgtcc agccagacct tggaaaccga tcctcctgtg
    16441 gctgcttttg tttatgatgc aagcttcatt aagcttcgtc aggtatctgt ttcttatact
    16501 ttcaacaatc agtttttgaa aaaggcagga attcaaaatc tcacactggg cctgatagga
    16561 agtaatctat ggattattca taaaaatctt ccctatgcag atcctgaatc cggactgtca
    16621 tcaggtagta tacaaggata ccaatccggg gtaatgcctg ctacaagaaa cttcgccttt
    16681 aatctgaaag ttaattttta aaccctatta ccatgaaaaa tatgatcata agctcccttc
    16741 tagcactgat gctcacgaac tgtacatcag ataatgtgaa tgatgatccg catgtagctt
    16801 acaacatgtc tcctgaacct cttcttacct atgcagaaaa ggagctaagc gactatatga
    16861 ccacgccaag cgttaatgaa aacaatttcc ggcttaccat gcaatactgg caggaggtaa
    16921 cttacgtaag tgaaagcaat tataatttta cagcaagaaa tgtctccaat aatgtttgga
    16981 tagacaatta tgtgaatgtt cttaataacc tgaataaggc taaagagctt atagaacaat
    17041 ttcaaccgcc agcctctgaa gtaaactcct ggccggctaa gaaacaaaat cagctggcga
    17101 taattgatat tatttcagtg tatacctttc aaaccgtggt tgatactttt ggagatatcc
    17161 cttacaccca agcccttaat tatgaaaaat atcctcttcc cacctacgac gatgatgcac
    17221 agatttatga aaaactaatt acacggctga aaacagacct caatctgctg aaggaaggag
    17281 aaggaacatt tggttccgga gatatctttt atagaggaga cataggaaag tggaaaaaat
    17341 ttggaaattc actgctttta aaattaggaa ttgctctgtc agacgtaaat ccctcattgg
    17401 ctcaatctac tataaatacg gctatttccg gtggagttat cataaatgaa acggataatg
    17461 cgaacttcag atatcaggaa gagacaccca attttaatcc attgtttgaa aaccttgcca
    17521 atagtggaag aagcgatttt tttggaggaa agccttttat agacttcctt aatgcaacat
    17581 ctgatcccag aagagctcaa tattttaagg atgtacatgg cgaatatatt ggtcaggtga
    17641 ttgggttacc agggattttc tccaattttt cggctcccgg actctttgct tacattcccg
    17701 ttactcccgg aaaaatactg accaatactg aagttgcttt ttacctggca gaagcagcag
    17761 ccagattcgg aattggcgga tctcctgatg ttctttacca aaatgcagta caggcatctt
    17821 tcgtagaatg ggggttttct gctcaggatg tacaggatta tctttcaaat catccttatg
    17881 atgcagccaa ctggaaaaaa tctattggag agcaggcttg ggttgctatg tacaatcatc
    17941 ctgtagtgtc ctggaacttt taccgtaggt tagattatcc tgttttacaa gctccgccaa
    18001 ctgctattgc caatgcgggc ggaaaagttc ctgtaagact tcaatatcca acattagaag
    18061 ccactaccaa tggaaccaat tatgctaaag ctgcaacagc tatagggggt gataagctta
    18121 ccaccaaagt tttttgggat gttcaataaa accagaagac cgaaattctg aacatatcag
    18181 tggatgactg ctacaaaaac taactattta aattataatt ttttttcata tctattaatt
    18241 tgtacactct ctaagcctgt atttctataa tacaggtttt tttatagatg tttaaaatct
    18301 ttcatagact ataattttcc tttcatagat gttttttcca agttatactt catttaatca
    18361 tttttgaagg gtcaataaca aacgattaga attatgaaag taaatggaat taaaaagctg
    18421 atgagcggtt ttattgtaat ggtaataatg ggaaccctct ttttcagctg caaaaacagt
    18481 gatgataatg atgagcctac cccaatttcc gggcagagca tagatccggt agtgggaaca
    18541 tttaaaggga ctatacgaat tgccactcag gattattata atgctattgt tgtggtttca
    18601 aaagtggatg ctactcatat taaggttcaa cctaaatctg gcgaagcata ttctgtagca
    18661 actcctaaag ttcttagcgc tgtaaatcct gtaggtgtag gagtgggagg aaatgatcca
    18721 gaaggaagcg ttaattatct tatttcaaca aaagccttac agatcagtac gaaaaaaaca
    18781 gcggctactg acgtggagtt ttattacgaa ggcactaaac aataataaaa gtaaatataa
    18841 tgtagttggt ttattattct caatggtgaa taatgttttg gcttaatgat tagcaataat
    18901 cttaagccaa tttttattta aaaaagttta agtccaataa ttccaactac aatcagtaat
    18961 gcagataata atcttaaaat acttgctgaa tcctggaaaa acaaaacacc caccaataaa
    19021 gttcctactg caccaattcc cgtccatacg gcataggctg tcccaatggg aatacttttc
    19081 tgggcatacc agagaaatgc gccgctcact gtcatacatg ctatcgaaaa catgatccag
    19141 ctccatttat tactttgagg ctgctgagat aacttaagac ctaatggcca tccgatttca
    19201 aaaattcctg caataattaa tgcaatccag ttcatactat ttgtttttaa tgattaggaa
    19261 tgaaaattgt gtttattcta tagtatttca ccctttttac catgcaaaat tatcagaacc
    19321 tgctcatatc caaaccaata aactgagtga ccctgcaaaa aatacagata gaacgtagta
    19381 tacctggagt gaatcgttaa acattttagc ctgaatatcc gaaatattga tacctttaag
    19441 ctatcaaaat aagaacagaa ccattttata tgttaacgga tatcatttcg cctcatctgg
    19501 atgttatttt ttgtggaatt aatcccggtt tgaaatcatc caatgacggc catcactttt
    19561 caggaagaag caatcgtttt tggaaagtaa tgcatcaatc aggatttaca ccttacgaaa
    19621 ttgaagcagt gaatgatact gttattctgg acttcggatg tggcttaaca acagctgttg
    19681 ccagagcaac gtcccgtgct gacgaacttt caaaagatga atttgatgaa gcgcttgaaa
    19741 cttttacaac caaaataacg aaatttcaac ctcaatatgt agcttttctg ggtaaagcgg
    19801 cctataaagc attctctaaa aagaaggaaa tccaatgggg gcagcagtca gaggatttct
    19861 gtggtgctaa aatatgggtt ttacctaata ccagcggctt gaatcgtgga ttttctctgg
    19921 atgatcttgt tgggtattat aaagaatttt atcaggatat tcacccatag taagttctat
    19981 attttgtttg gtttacttac atatttattc ccgtttacaa aaaatctcca gggtaacaga
    20041 gcgtcttcct gtgcataagc tacacctata cgaggccctg caacaatagt atcagaagaa
    20101 tagtgaatcc catgatcttc aatccagata tcacttccat tcagatcttt tttattgaaa
    20161 gaacgatcaa ttcccaatgc tttagcagca gatccggggc cggcagaaat ggctgctttg
    20221 gaagccggca tatttctcct catttccata atttcttttc ctattaatgg ctcaacagcc
    20281 ctcaccagaa cagcatgagg gtcatcctcc acagaagtca caacattgaa aaggtgatgg
    20341 attccataac ataagtacac ataggaaatc ccgccctgat tatataaagt ctcagttctg
    20401 tctgtacgcc tgccgccata agcatgagaa gctttgtctg atactccatg atacgcttca
    20461 gtctctacaa taattcctgc tgttatttca ccatcaatat ttgtaaaaag tacttttccc
    20521 agaagatcct gagccataaa aagaacgtct tgattggaat aataggagag agggagtttc
    20581 aacggggtgg gttttagtaa tgatttaccc aaaattagtg ataatttgtt aaatggaagg
    20641 cgggaagttg gaagttacta ttcagcatat aacgtctgaa gatcttttta aattcttaaa
    20701 acatttatta ataggagaca gcctcaccac ctgatataaa gtacttccag ccctcagctt
    20761 ccttactcaa aaaaaagccc cacattcctg tgagactttc attcattatc tatcttcctc
    20821 caggaggaca atgttctttt aaatatttcg taaacatggt agccaaatgc agtgatgttc
    20881 cttccccttc actgatagag tgcgttctgt tagggtaaga catcagctga aactgtttgt
    20941 tgtattttac aagctcatta atataaactt ccgtattctg ataatgtaca ttatcatcac
    21001 cggttccgtg aaccaataga agattccctt tcagattttt agcataagcc aatggagaac
    21061 cgttgaca
//
