LOCUS       NZ_CP119796            11773 bp    DNA     circular CON 12-MAY-2024
DEFINITION  Halomontanus rarus strain TS33 chromosome, complete genome.
ACCESSION   NZ_CP119796
VERSION     NZ_CP119796.1
KEYWORDS    RefSeq.
SOURCE      Halomontanus rarus
  ORGANISM  Halomontanus rarus
            Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria;
            Halobacteriales; Natrialbaceae; Halomontanus.
REFERENCE   1  (bases 1 to 4121906)
  AUTHORS   Cui,H.-L.
  TITLE     Diverse halophilic archaea isolated from saline environments
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 4121906)
  AUTHORS   Cui,H.-L.
  TITLE     Direct Submission
  JOURNAL   Submitted (15-MAR-2023) School of Food and Biological Engineering,
            Jiangsu University, 301 Xuefu Road, Zhenjiang, Jiangsu 212013, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: HGAP v. 4
            Genome Representation             :: Full
            Expected Final Version            :: No
            Genome Coverage                   :: 774.26x
            Sequencing Technology             :: PacBio Sequel
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_029338335.1-RS_2024_05_12
            Annotation Date                   :: 05/12/2024 18:47:08
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,559
            CDSs (total)                      :: 5,503
            Genes (coding)                    :: 5,371
            CDSs (with protein)               :: 5,371
            Genes (RNA)                       :: 56
            rRNAs                             :: 2, 2, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 2, 2, 2 (5S, 16S, 23S)
            tRNAs                             :: 48
            ncRNAs                            :: 2
            Pseudo Genes (total)              :: 132
            CDSs (without protein)            :: 132
            Pseudo Genes (ambiguous residues) :: 0 of 132
            Pseudo Genes (frameshifted)       :: 52 of 132
            Pseudo Genes (incomplete)         :: 95 of 132
            Pseudo Genes (internal stop)      :: 33 of 132
            Pseudo Genes (multiple problems)  :: 41 of 132
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 08:01:44
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 3575891
            Orig. end                         :: 3587664
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP119796.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..11773
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="8"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..11773
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..11773
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:6773](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..6773)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     gene            109..1290
                     /db_xref="GeneID:79282925"
                     /locus_tag="P1Y19_RS17235"
     CDS             109..1290
                     /codon_start=1
                     /db_xref="GeneID:79282925"
                     /inference="COORDINATES: protein motif:HMM:TIGR04213.1"
                     /locus_tag="P1Y19_RS17235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="PGF-pre-PGF domain-containing protein"
                     /protein_id="WP_276253610.1"
                     /transl_table=11
                     /translation="MNHRPFGRLALAIVLVSVLFAPATVAGTADPQPTPAAYYGELTAA
                     EEPIPAGVTVTAEIDGEVRGELVTTEAGRFGGAGAFEPKLQVDGESGDAGAVVRFYVDG
                     VEAAETVQWQASDVRSVDLSVADPWESADGDGGGGFAPGTGGGGFPGGDTTSDVNGSDE
                     NSTDDTPATVDVRPDPTEPGVTDVAVTGGRAGETVSTNLGTDEDAEFSMTGLTLVPVVD
                     GDFTLRISTSPTLPDGTPALADEGVIEYVTVDHSISDANLEEVTFSFAIGTDVVADRGV
                     DPDAIALYRYHDDRWTELLTSHVDTVNGRHVFDSDSPGLSVFAVAPRGATADSSHTDET
                     SDAGDDSDSSGERVADTDDTAGSAFDRPVLLLAVVVVAIVVIVGFRYGRSARR"
     gene            complement(1314..2279)
                     /db_xref="GeneID:79282926"
                     /locus_tag="P1Y19_RS17240"
     CDS             complement(1314..2279)
                     /codon_start=1
                     /db_xref="GeneID:79282926"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007141791.1"
                     /locus_tag="P1Y19_RS17240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF5794 domain-containing protein"
                     /protein_id="WP_276253611.1"
                     /transl_table=11
                     /translation="MSTSQHPVALRLESVVGGDARLLAMVMGLPLIDGVFAALVLSGAL
                     DDPVGAIQVGLLIFGGSATVAVILADMDGSPREQAKIVLGVGIPLILLAAVQAALAPAL
                     DSILDIVIFERFAALVIMAIAAKTASATIGDYLPSPGVIIALGLVASIDLAGAELAVLH
                     DPGLVINATGAAVVGVAFALSIALLGPYLREYMDIDRFRFGSAVALGLLPLAILGMPFG
                     NAPLAVLGVAALFAFDPDRDELADTISGMMGDERGARADGGSRAEAESDAGEDGTGSEA
                     NSNSVADTDTDTDNDPLDEPYPGPGVNDGSDDGSSRAPWL"
     gene            2851..4350
                     /db_xref="GeneID:79282927"
                     /gene="guaB"
                     /locus_tag="P1Y19_RS17245"
     CDS             2851..4350
                     /EC_number="1.1.1.205"
                     /GO_function="GO:0003938 - IMP dehydrogenase activity
                     [Evidence IEA]"
                     /GO_process="GO:0009152 - purine ribonucleotide
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:79282927"
                     /gene="guaB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005559492.1"
                     /locus_tag="P1Y19_RS17245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="IMP dehydrogenase"
                     /protein_id="WP_276253612.1"
                     /transl_table=11
                     /translation="MANDVPEHEPYSSKLRVPEALTFDDVLLRPKESRVEPDEADLTSR
                     VSRTVEVSVPILSAAMDTVTEAEMAIAMARHGGMGVIHRNMNIDGMVEEIHSVKRADEL
                     IIPHESVVTADPEMTVREVDEMMVREGVGGAPVTNTNGEVLGIISSTDIRPHLEVGEND
                     SVTEAMTDEVITAPQDIDAREAFDLMYEHKIERVPVVDDENLLVGLVTMQGILQRREYK
                     EAARDDDGKLRCGVAVSPFETDRAIAADEADADVLFIDTAHAHNLNVIDGAREIKESVE
                     ADVVVGNVGTREAAEDLVDFADGIKVGIGPGSICTTRVVSGAGMPQITAVSQVADVASE
                     HDVPVIADGGIRYSGDAIKAIAAGADAVMLGSYFAGTEEAPGRVVTMNGKKYKQYRGMG
                     SVGAMKSGDADRYLKEDPEDEEEYVPEGVEAATPYKGTLKSELHQLAGGMQSGMGYVGA
                     ETVPAFKERAEFVRVSSAGQAEGHAHDVVITDEAPNYSPNE"
     gene            4535..4933
                     /db_xref="GeneID:79282928"
                     /locus_tag="P1Y19_RS17250"
     CDS             4535..4933
                     /codon_start=1
                     /db_xref="GeneID:79282928"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="P1Y19_RS17250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_207588999.1"
                     /transl_table=11
                     /translation="MNRRTLLRAGITLPFVALTGCLSSIQDLRLSTPIAVQIENEMDDN
                     RNVVITAHALADDRQTYDEAVSASPDQTTSVGHLTDEEQHVRIALVDDDGNELDVEETF
                     VDERTKSLAIVIVDEELELEVDQRERSE"
     gene            complement(5001..6773)
                     /db_xref="GeneID:79282929"
                     /locus_tag="P1Y19_RS17255"
     CDS             complement(5001..6773)
                     /codon_start=1
                     /db_xref="GeneID:79282929"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: YcaO"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: TIGR03604"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014863164.1"
                     /locus_tag="P1Y19_RS17255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="YcaO-like family protein"
                     /protein_id="WP_276253613.1"
                     /sec_met_domain="YcaO (E-value: 8.8e-62, bitscore: 207.6,
                     seeds: 127, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR03604 (E-value: 6.5e-71, bitscore:
                     237.0, seeds: 25, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEVHIVGDDPVRDAVATALEDVDVDVRSADPPALEDARFAVVTDV
                     TGASTFERANDAARAGNTPWIAVEVGGVGGHPLPEIDAAVAGFSAKTGCYECLRARVAS
                     TTEESTDRPSADRSAARFAGSIAGHECVRVFSGAENSIFGHVREVPHARRRFLPVPGCT
                     CQSAARDRTLERDDETLPLETALDRAEAAIDDRVGLISGLGELESFPAPYYLATAADTT
                     AYSDAKAPLQSAGVAVDWDRAMMKAVGEALERYCAGVYRDDDFVRASADGLERAVAPTD
                     LVRPADAPAFDSASEHRWVLGERLATGEAIHLPAAAVQFPQPGERLVPSITTGLGLGSS
                     TVDALVSGLTEVVERDATMLAWYSTFEPLGLAVDDETFETLERRARSEGLVVSALLVTQ
                     DIDVPVVAVAVHREGERDTWEDEWEWPHFAVGSAADLDATAAARSALAEALQNWMELRS
                     MGPDDAADAGGAIAEYASFPDRVREFVDGDGDGDGDDDRTIPAASVGPDPVPTGSAALE
                     TLVDRVTDVGLSPVAARLTTRDVAELGFEGVRVVVPGAQPLFTGEAFFGERARTVPDDL
                     GFEPRLERAYHPFP"
     gene            complement(6968..7420)
                     /db_xref="GeneID:79282930"
                     /locus_tag="P1Y19_RS17260"
     CDS             complement(6968..7420)
                     /codon_start=1
                     /db_xref="GeneID:79282930"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006166961.1"
                     /locus_tag="P1Y19_RS17260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="RNA-binding protein"
                     /protein_id="WP_276253614.1"
                     /transl_table=11
                     /translation="MPQIPLHYVDLRTFCYATEDEKRVETALRTFLPEEFEIERVESEG
                     HYGDRILVLSARVERADEIRHVLARLAELEELDQLLAELDQRVTENTELFLRLDKQAAF
                     GGDVRLGDGITFRAKVEAYPAKKEAAVENAQEVLERLEDEADDDDA"
     gene            complement(7506..7709)
                     /db_xref="GeneID:79282931"
                     /locus_tag="P1Y19_RS17265"
     CDS             complement(7506..7709)
                     /codon_start=1
                     /db_xref="GeneID:79282931"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006087917.1"
                     /locus_tag="P1Y19_RS17265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF1918 domain-containing protein"
                     /protein_id="WP_276253615.1"
                     /transl_table=11
                     /translation="MSFEEDDRVVLDDQHSEFDGETGTITQTIESMFGDVTYTISFEDG
                     QETGVPEDSLEAAEDEDDEDDE"
     gene            complement(7890..8570)
                     /db_xref="GeneID:79282932"
                     /locus_tag="P1Y19_RS17270"
     CDS             complement(7890..8570)
                     /GO_function="GO:0019172 - glyoxalase III activity
                     [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:79282932"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006180508.1"
                     /locus_tag="P1Y19_RS17270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="type 1 glutamine amidotransferase
                     domain-containing protein"
                     /protein_id="WP_276253616.1"
                     /transl_table=11
                     /translation="MTKALFVVSEEGYWGEECVAPLEAFSDAGIEITVATPTGSPPVID
                     EMSLDPDEVGEETAAHVEEVHASDERLNDPVAVADTHAEDYDLVVFPGGHGTEWDINQD
                     YHARALLREAVEGDDGKALVVCHAVGMLGFARDRHGAFLVNGRDVTGFPNAWEEEIVDD
                     RGLMPDGRKLPYWVEDEVEAAGGNWDAELDDDTSVTVDGDLITARGPESSEAAAETVLE
                     ELDY"
     gene            complement(8777..9016)
                     /db_xref="GeneID:79282933"
                     /locus_tag="P1Y19_RS17275"
     CDS             complement(8777..9016)
                     /codon_start=1
                     /db_xref="GeneID:79282933"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006431198.1"
                     /locus_tag="P1Y19_RS17275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="PRC-barrel domain containing protein"
                     /protein_id="WP_276253617.1"
                     /transl_table=11
                     /translation="MCANFTDDDEGKRVVNANGEEIGIVQHVEGGSVHVDPDPGITDSI
                     KSKLGWGDSDEDTYALDENNVESISDDEVRLRRL"
     gene            complement(9119..9526)
                     /db_xref="GeneID:79282934"
                     /locus_tag="P1Y19_RS17280"
     CDS             complement(9119..9526)
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:79282934"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015788324.1"
                     /locus_tag="P1Y19_RS17280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_276253618.1"
                     /transl_table=11
                     /translation="MDVRELGDDELVDAVPILRQLWTDREPDEVLEWTAAEGYYPFGRF
                     DGDELIAVAGVLECELLHHAPHAWVSDLVVDEQRRGEGHGTALLEFVEQWATDRGCEYV
                     ALASPLAKEAVHEFYGTRSYEKWGYVLETEL"
     gene            9813..10229
                     /db_xref="GeneID:79282935"
                     /locus_tag="P1Y19_RS17285"
     CDS             9813..10229
                     /codon_start=1
                     /db_xref="GeneID:79282935"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006108653.1"
                     /locus_tag="P1Y19_RS17285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="Hsp20/alpha crystallin family protein"
                     /protein_id="WP_276255739.1"
                     /transl_table=11
                     /translation="MSRQFESAARSWETNAGGESGTKFDFSIGESVNGLDLAEGDDEFV
                     VTVDVPGYETADIEVRLSGANDVLHVDGERSRETDADEDQFIRRERRAQSFSRRVQLPQ
                     PVDDEDVTARLNNGVLTITLGKAESDESHHIDIE"
     gene            complement(10262..11290)
                     /db_xref="GeneID:79282936"
                     /locus_tag="P1Y19_RS17290"
     CDS             complement(10262..11290)
                     /EC_number="3.1.3.7"
                     /GO_function="GO:0003676 - nucleic acid binding [Evidence
                     IEA]"
                     /GO_function="GO:0004527 - exonuclease activity [Evidence
                     IEA]"
                     /GO_function="GO:0008441 - 3'(2'),5'-bisphosphate
                     nucleotidase activity [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:79282936"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006674487.1"
                     /locus_tag="P1Y19_RS17290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="bifunctional oligoribonuclease/PAP phosphatase
                     NrnA"
                     /protein_id="WP_276253619.1"
                     /transl_table=11
                     /translation="MSRAATLASVLDEASALVIVCHDNPDPDCLASALALERIARSRDV
                     DDVLIVYGGEISHQQNRAFVNMLEIDVVAFDELGDERRIEDAGCVAFVDHSRPGGNTEA
                     PLSLEPSIIVDHHPTEAPDARFTDVRTEYGATSTIFVEYLLDLEVAMTTRLASALLFAL
                     HRERLDFIREPTAREYEAALAVYPDADLEVLEQLYGTAFSPATIDAIGRAITTRERRGS
                     SLVASVDRTTETDALPQAADYLLNLEGVDTVLVYGIVNGTIRMSGRSIDPRVHMGETLE
                     DAYGGLGNAGGHHDMAGGRIELGLFADEADDEADLLSFVSTRITRRFFDTLHLDGDEDL
                     EH"
ORIGIN
        1 cggcgcgcgt tcccgacggc gtcacgtatc ccgaattcga ggagattctt acgatggacg
       61 gctacctcgg gggactcgag gcgagataag caattgatac cgatgcctat gaaccaccga
      121 ccgttcggcc gactcgccct cgcgatcgtt ctcgtcagcg tgctgttcgc gccggcgacc
      181 gtcgctggaa ctgcggaccc gcagccgacg ccggccgcgt actacggcga actgacggcc
      241 gccgaggaac cgatccccgc cggcgtcacc gttactgcgg agatcgacgg cgaggtccgc
      301 ggcgaactcg tcacgacgga ggccggccgc ttcggcggcg ccggcgcgtt cgaaccgaaa
      361 ctgcaggtcg acggtgagag cggcgacgcc ggtgcagtcg tccggttcta cgtcgacggc
      421 gtggaagccg ccgaaaccgt ccagtggcag gcgagcgacg ttcgatccgt cgacctctcc
      481 gtggccgatc cctgggagag cgcggacggc gacggtggag gtggcttcgc tcccggaacc
      541 ggcggcggtg ggttccccgg aggcgacacc acgagtgacg tgaacggcag cgacgagaat
      601 tcgaccgacg acacgcccgc gaccgtcgac gttcgccccg atccgaccga accgggcgta
      661 accgacgtgg ccgtcaccgg cggacgagcc ggcgagacgg tgtcgacgaa tctcggtacg
      721 gacgaggacg ccgagttctc gatgaccggg ctcactctcg tccccgtcgt cgacggtgac
      781 ttcaccctcc gaatctcgac gtcgccgacg ctccccgacg ggactcccgc actcgccgac
      841 gagggcgtaa tcgagtacgt gaccgtcgac cactccatct cggacgcgaa cctcgaggag
      901 gtgacgttct cgttcgcgat cggcactgac gtggtagcag accgcggcgt cgatccggat
      961 gcgatcgcac tctaccgcta ccacgacgat cggtggacgg agctgctgac ctcgcacgtc
     1021 gacacggtga acggtcgaca cgtcttcgac agcgattcgc ccggcctctc cgtatttgcg
     1081 gtcgcacccc ggggagcgac ggcggactcc tcccacacgg acgaaacgag cgacgcgggc
     1141 gacgactcgg actcgagtgg cgagcgcgtc gccgacacgg acgataccgc tggctcggcg
     1201 ttcgaccgac cggtactgtt gctcgccgtc gtggtcgtcg ccatcgtcgt catcgtcgga
     1261 ttccggtacg gacgttccgc tcgacgctga tcggcggtcg actgctcgac cgtctacagc
     1321 cagggtgccc ggctcgaccc gtcgtccgag ccgtcgttca caccgggtcc gggatacggc
     1381 tcgtcgagcg ggtcgttgtc ggtgtcggtg tcggtatcgg cgacggagtt cgaattcgct
     1441 tcagaccccg ttccatcctc gccagcgtcg gactcggctt cggcacgcga tccgccgtcg
     1501 gctcgagcgc cgcgctcgtc acccatcata ccgctgatag tgtcggcgag ttcgtcgcgg
     1561 tcgggatcga acgcgaacag tgcggccacc cccagcacgg ccagcggggc gtttccgaac
     1621 ggcatcccga ggatcgccag cgggagtagt ccgagcgcga ccgcgcttcc gaatcggaac
     1681 cggtcgatgt ccatgtactc gcgcaggtac ggcccgagca gggcgatcga cagcgcgaac
     1741 gcgacgccga cgacggccgc gcccgtggcg ttgatcacca gtccgggatc gtggaggacg
     1801 gccagttcgg cgccggcgag gtcgatactc gcgaccaggc ccagcgcgat gatgacgccc
     1861 ggactcggca ggtagtcgcc gatcgtcgcg ctggcggtct tggccgcgat ggccatgatc
     1921 acgagcgcgg cgaagcgctc gaagatcacg atgtcgagga tgctatccag tgccggcgcg
     1981 agggccgctt gcaccgctgc cagaaggatc agaggtattc ctacccccag aacgatcttc
     2041 gcctgttctc gcggcgagcc gtccatatcg gcgaggatga ccgccacggt ggcgctgcca
     2101 ccgaagatga gcaggccgac ctggatcgcg cctacgggat cgtccagcgc gccggagaga
     2161 accagcgccg cgaagacgcc gtcgatcagc ggcaatccca tgaccatcgc gagcagtctg
     2221 gcgtcaccgc cgacgacaga ctcgagacgg agggcgaccg gatgctgaga cgtgctcatc
     2281 gattacgatc gatggccgta acccgtggcc agcggggagg ataacggact gtcccgttgt
     2341 gggtccaggt ggaggctccg cgcggtcttg tcggcgggga gccagtcccg gtcccgttcg
     2401 tggccgttcg ctgcgaatgt gaatttcccg aatgtacccg tggcgacgga actgctgttc
     2461 gtctggccag cacatcgggt ctcacccgtt ctcgcagcgt tcatgaataa ttcaaacaga
     2521 cctgcgtcaa taaaggttcc gtgggaaacg gacacactct gcaagcattc taaaccggat
     2581 ccgtgaattt ctaccagaaa ataacactgt tgtgcggatc tcgacataga agtcggcaat
     2641 tgcaccgtcg tgtcagaggc ctgtccggtg ctcactcacc cgttctcgac gtcgtctttc
     2701 acgttgaatc cgctcctcga gtcgtctcga gcccgcggac gagcggagac gaatcggtta
     2761 cgagcgtggg aaccgctctc gtacgggatc ggctgcctgt cggccgtcgt atctcgcaac
     2821 gtttttcccc ggcggttccg gacagtttac atggcgaacg acgttcctga gcacgagccc
     2881 tattcctcga aattacgggt accagaagca ttgaccttcg acgacgtctt gctccgcccg
     2941 aaggagagtc gcgtcgaacc cgacgaagcc gatctcacca gccgagtctc gagaaccgtc
     3001 gaggtttcgg tgccgatcct ttcggcggcg atggacaccg tcaccgaggc ggagatggcg
     3061 atcgcgatgg ctcgccacgg cgggatgggc gtcatccacc gaaacatgaa tatcgacggg
     3121 atggtcgagg agattcacag cgtcaaacgc gcggacgaac tcatcatccc acacgagtcg
     3181 gtcgttacgg ccgatcccga gatgaccgtt cgcgaagtcg acgagatgat ggtccgcgag
     3241 ggcgtcggcg gcgctcccgt caccaacact aacggcgagg tgctcggaat catctcgagt
     3301 acggacattc gccctcatct cgaggtcggc gagaacgact cggtcacgga agcgatgacc
     3361 gacgaggtca tcaccgcgcc acaggacatc gacgcccgcg aggcgttcga cctgatgtac
     3421 gagcacaaga tcgagcgcgt tcccgtcgtg gacgacgaga acctcctggt tggactcgtg
     3481 acgatgcagg ggatcctcca gcgtcgggag tacaaggagg ccgcccgaga cgacgacgga
     3541 aaactccgct gtggcgtcgc cgtcagcccg ttcgaaactg accgtgcgat cgccgccgac
     3601 gaggccgatg cggacgtgct gtttatcgac actgcacacg cgcacaacct gaacgtcatc
     3661 gacggtgccc gcgagatcaa ggagtccgtc gaggccgacg tcgtcgtcgg aaacgtcggt
     3721 actcgggagg ccgccgagga tctcgtggat ttcgcggacg gaatcaaggt cggaatcggt
     3781 cccggctcga tctgtaccac gcgcgtcgtc tccggggccg gaatgcccca gatcacggcc
     3841 gtctcgcagg tcgcggacgt cgcgagcgaa cacgacgtgc ccgtgatcgc cgacggcggc
     3901 atccgctact cgggcgacgc gatcaaggcg atcgccgccg gcgccgacgc cgtcatgctc
     3961 ggttcgtact tcgcgggaac cgaagaggcg ccagggcgcg tcgtcaccat gaacggcaag
     4021 aagtacaagc agtaccgcgg gatgggaagc gtcggtgcga tgaaatccgg tgacgccgac
     4081 cgctacctca aggaggaccc cgaggacgaa gaggagtacg tcccggaagg cgtcgaagcc
     4141 gcgacaccct acaaaggaac gctcaaatcc gaacttcacc agctcgccgg cgggatgcag
     4201 tccggcatgg gctacgtcgg cgccgaaacc gtccccgcgt tcaaagagcg cgccgagttc
     4261 gtccgcgtct cgagtgcggg gcaggcggag gggcacgccc acgacgtcgt tatcaccgac
     4321 gaagcgccca actactcgcc gaacgagtaa gcgccacacg cgatccggct ccgccgctcg
     4381 cgctcgcgct cgcactgggc cagtgatagt gatcggtttc cgcgttctat tcgagtcacg
     4441 gttggcacgt cccgggagac cgttcccggt ctcgacgacc cgaccgagaa cgcgaaaagc
     4501 aacacctaca gtcgctcggt tactgttgtc gactgtgaac cgtcgtacgc tacttcgggc
     4561 cggtatcacc ctcccgttcg tcgctctcac cggctgtctc agctcgattc aggatctccg
     4621 actcagtacg ccgatcgcgg tccagatcga aaacgagatg gacgacaatc gaaacgtggt
     4681 gatcaccgcc cacgcgctcg cggacgaccg acagacctac gacgaggccg tcagtgcgtc
     4741 gcccgaccag acgacgagcg tcggccacct cacggacgaa gaacagcacg ttcgcatcgc
     4801 gctcgtcgac gacgacggga acgaactcga cgtcgaagag acgttcgtcg acgaacggac
     4861 caagagtctt gccatcgtga tcgtcgacga agagctcgaa ctcgaagtcg atcagcgcga
     4921 gcgatccgaa tagccagttt tcactccgta ttctcggtct cgtcgatcgt cgtctctcta
     4981 ctgctccagt acggcgacaa ctacgggaac gggtgatacg cccgctcgag tcgtggttcg
     5041 aatccgaggt cgtcggggac ggttcgtgcg cgctcgccga agaacgcctc gccggtgaac
     5101 agcggctgcg cgccgggaac gacgacgcga acgccctcga atccgagttc cgcgacgtct
     5161 ctcgtcgtga gccgtgccgc gacgggggag agtccgacgt cggtgacgcg atcgacgagc
     5221 gtctcgagtg cagcgctccc cgtcgggacc ggatcggggc cgaccgaggc ggccggaatc
     5281 gtgcggtcgt cgtcgccgtc gccgtcgccg tcgccgtcga cgaactcgcg gacccgatcg
     5341 ggaaacgagg cgtactcggc gatcgcgccg ccggcatccg cggcgtcgtc gggacccatc
     5401 gaccgcaact ccatccagtt ctgcagcgct tcggctagcg ccgaccgcgc cgctgcggtc
     5461 gcgtcgaggt cggccgccga accgaccgcg aagtggggcc actcccactc gtcctcccac
     5521 gtatcgcgtt ctccctctcg gtggaccgcg actgcgacga ccgggacgtc gatatcttgc
     5581 gtgactaaca gcgccgagac cacgagcccc tcactccgag cacgccgctc gagcgtctcg
     5641 aaggtctcgt cgtcgacggc gagtcccagc ggctcgaacg tggagtacca cgcgagcatc
     5701 gtcgcgtcgc gttcgacgac ctccgtcagc ccggagacga gcgcgtcgac ggtcgacgag
     5761 ccgagtccga gcccggtcgt gatcgacggg accagccgtt cgcccggttg cgggaactga
     5821 acggcggccg cgggcaggtg aatcgcctcg ccggtcgcga gtcgctcgcc gaggacccac
     5881 cggtgttcgc tcgcggaatc gaacgcgggc gcgtccgcgg gtcgaacgag gtcggtcggc
     5941 gccacggcgc gctcgaggcc gtcggcgctc gcgcggacga agtcgtcgtc acggtagacg
     6001 cccgcacagt agcgctcgag ggcttcgccg acggccttca tcatcgctcg atcccagtcg
     6061 acggcgaccc cggcggattg gagcggcgct ttggcgtcgc tgtacgcggt ggtgtcggcg
     6121 gcggtcgcga ggtagtaggg agcggggaac gactcgagtt cgcccagccc cgagatcagc
     6181 ccgacgcggt cgtcgatcgc ggcctccgcc cggtcgagcg cggtttcgag ggggagcgtc
     6241 tcgtcgtcgc gctcgagcgt tcgatcgcgc gccgccgact ggcacgtaca gccggggacc
     6301 ggcaagaagc gtcggcgggc gtggggaacc tcgcggacgt gaccgaagat cgagttctcg
     6361 gcgccagaga acacgcgcac acactcgtgg cccgcgatcg aaccggcgaa ccgggccgca
     6421 ctccggtcgg cgctcggtcg atccgtcgat tcctcggtcg tcgaggcgac ccgggcccgg
     6481 agacactcgt aacaccccgt cttcgcggag aaccccgcca ccgcggcgtc gatctccggg
     6541 agcgggtgcc cgccgacgcc gccgacttcg acggcgatcc agggcgtgtt acccgctcga
     6601 gcggcgtcgt tcgctcgctc gaacgtcgat gcgccagtga cgtcggtgac gaccgcgaaa
     6661 cgggcgtcct cgagggccgg cggatcggcc gatcggacgt cgacgtcgac gtcctcgagc
     6721 gcggtggcga cggcgtcccg aacggggtcg tcgccgacga tgtgaacttc catatcgggt
     6781 gtctcggtgg ccggtgggaa aaacggcccg ctcgcggtcg gctctcgggt cgcgtgaacg
     6841 tgcggaggag tgtgagtccg gatgtgggtg cgaacgtaga aggacgcaga acgcgtgacg
     6901 tgtcggcgtc tcgaaaccga ggaccgacta tcgaaatcga accagcagcg aacggggact
     6961 cgccgtctta cgcgtcatcg tcgtccgcct cgtcctcgag tcgctcgaga acctcctggg
     7021 cgttctcgac ggcggcctcc ttcttcgcgg ggtaagcctc gactttcgcc cggaaggtga
     7081 tgccgtcgcc gagtcgaacg tcgccgccga aggcggcctg tttgtctagt cgcaagaaca
     7141 gttccgtgtt ctcggtcact cgctggtcga gttccgcgag caactggtcg agttcctcga
     7201 gttcggcgag tcgagcgagg acgtgtcgga tctcgtcggc ccgttcgacg cgggccgaga
     7261 ggacgaggat gcggtcgccg tagtggccct cgctctcgac gcgttcgatc tcgaactcct
     7321 cggggagaaa ggttcgaagc gcggtctcga cgcgtttttc gtcctcggtg gcgtagcaaa
     7381 acgttcgcag gtcgacgtag tgcagcggga tctgtggcat tcgtctgtgt gaggagggct
     7441 cgagtgtaag tgtaagtatg tctgcgagtg tctgtacagg tgcgaatgcg agcgcggtcg
     7501 gccggttatt cgtcgtcttc gtcgtcttcg tcctcggccg cctcgagcga atcctcggga
     7561 acgccggttt cctgtccgtc ctcgaagctg atcgtgtagg tgacgtcgcc gaacatcgat
     7621 tcgatcgtct gcgtgatcgt tccagtttcg ccgtcgaact cgctgtgctg gtcgtccagc
     7681 acgacgcggt cgtcttcctc gaagctcata cctgcagttc cccgccgcgg ggtaaaaagg
     7741 gactgattca cggcaacgac gcccgagacc ggtttggact cctcgaaacg aagtgatcga
     7801 attatctgta acgccgagcg ctcgagaacg aagatccgaa agctgagaac cgagaacgga
     7861 actccgaaat tcgaccagga cgactcgagt tagtagtcga gttcctcgag caccgtctct
     7921 gcggccgcct ccgaggactc cggcccgcgg gcggtgatga ggtcgccgtc gacggtcacg
     7981 ctggtgtcgt cgtcgagttc ggcgtcccag ttgccgccgg cggcctcgac ctcgtcttcg
     8041 acccagtagg ggagtttgcg gccgtcgggc atcaggcccc gatcgtcgac gatctcctct
     8101 tcccaggcgt tggggaaacc ggtgacgtcc cggccgttga cgaggaacgc gccgtggcga
     8161 tcgcgggcga atcccaacat accgacggcg tgacagacga cgagggcctt cccgtcgtcg
     8221 ccctcgacag cctcacggag aagcgcgcgg gcgtgatagt cctgattgat gtcccactcg
     8281 gtgccgtggc cgccggggaa gacgacgagg tcgtaatcct cggcgtgggt gtcggcgact
     8341 gcgaccggat cgttgagtcg ctcgtccgag gcgtggacct cctcgacgtg ggcggcggtt
     8401 tcctcgccga cctcgtccgg atcgagcgac atctcgtcga tcaccggcgg cgaccccgtc
     8461 ggcgtcgcca ccgtgatctc gatccccgca tccgagaacg cctcgagcgg cgcgacgcat
     8521 tcctctcccc agtacccttc ctcgctaacg acgaacaacg ccttcgtcat actcggatct
     8581 acgactgtag acagtaaaaa tcctcgccgg aacgtgccgg tcgccctcga gagcggtctc
     8641 gaaacgagtc gagatggggg ctatcacaat gggagtgtag ccggctatcc ggcggtcacg
     8701 cgtaccagaa tcgagtcgac cggtgtgccg gtcgccgtcg acacgcggtc acctcgactt
     8761 ccgaccacaa tcgccgctag agccgtcgca gcctcacttc gtcgtccgag atcgattcga
     8821 cgttattttc gtcgagtgcg tacgtgtcct cgtcggaatc gccccagccg agtttggact
     8881 tgatcgaatc cgttattccc gggtcggggt cgacgtggac cgatccacct tcgacgtgct
     8941 gaacgattcc gatctcctcg ccgttggcgt tgacgactcg tttcccttcg tcgtcgtccg
     9001 tgaagttagc gcacatacac cgtgacggca tcacccaatc acgtatagct gatacaggca
     9061 tatgctggcc aaaagcgggt gtggtcgtga ccgggacgat cgagcggacc gctcgcggtc
     9121 agagctcggt ctcgagcacg tatccccact tctcgtacga tcgcgttccg tagaactcgt
     9181 ggaccgcttc tttggccagc ggtgacgcca gcgcgacgta ctcacagcct cggtcggtcg
     9241 cccactgctc gacgaactcg aggagcgccg tcccgtgacc ctcgcctcgc cgctgttcgt
     9301 cgacgacgag gtcggacacc cacgcgtgcg gtgcgtggtg gagcagttcg cactcgagga
     9361 cgccggcgac ggcgatcagt tcgtcgccgt cgaaccggcc gaacgggtag tatccctccg
     9421 cggcggtcca ctcgaggacc tcgtcgggct cgcggtcggt ccagagctgt cggaggatcg
     9481 gaaccgcgtc gactagctcg tcgtcaccca gttcacgaac gtccatggtc cacgttttgg
     9541 ctggaagcgg agcgcaaaaa gcgtgttcga tacacgatat cgtgagacga atacgtcgca
     9601 cgacgcgttg tgctcgagac cggtcgtcac gagagaccgt caggacgtgt gtaggtgcgt
     9661 tttattggcg tccggagggt caataacggg agggaatcgc tatgagagac agagacaagg
     9721 actggagcag agacagaaac ggagacctgg acagagaccg cacgcgaggg agaccgaacc
     9781 cgtttcaggg cctcgagaac ctcttcgaac agatgagccg gcagttcgag agcgcggcgc
     9841 ggtcctggga gacgaacgcc ggtggcgagt ccggaaccaa attcgacttc tcgatcggcg
     9901 agtcggtcaa cggcctcgac ctcgcggagg gggacgacga gttcgtcgtc acggtcgacg
     9961 ttcctggcta cgagaccgcc gatatcgagg tgcgcctgtc gggtgcgaac gacgtactgc
    10021 acgtcgacgg tgaacgaagc cgcgagaccg acgcggacga agatcagttc attcgtcgcg
    10081 agcggcgggc gcagtcgttt agccgtcgcg tgcaactccc gcaaccggtc gacgacgagg
    10141 acgtcaccgc ccgtctcaac aacggtgtgt tgacgatcac gctcggcaag gcagaatccg
    10201 acgaatcaca ccacatcgat atcgaatagc gctcgagagc gccgaaacga tcggctttcg
    10261 atcagtgctc gaggtcttcg tcgccgtcga ggtggagcgt gtcgaagaat cggcgagtga
    10321 tccgcgtcga aacgaacgag aggaggtcgg cttcgtcgtc ggcctcgtcg gcgaagagcc
    10381 cgagttcgat ccggccgccg gccatgtcgt ggtgaccgcc ggcgttgccc aacccgccgt
    10441 aggcgtcctc gagcgtctcg cccatgtgga ctcgcggatc gatcgaacgg ccgctcattc
    10501 ggatggttcc gttgacgatc ccgtagacga gcaccgtatc gacgccctcg aggttgagca
    10561 ggtagtcggc ggcctgtgga agggcgtcgg tctcggtggt ccgatcgacg ctcgcgacca
    10621 gcgacgatcc tcgccgctct cgagtcgtga tcgcgcggcc gatcgcgtcg atcgtcgccg
    10681 gtgagaaggc ggtcccgtac agttgttcga gtacctcgag atcagcgtcc gggtaaaccg
    10741 cgagggcggc ttcgtactcg cgagcggtcg gctcgcggat gaaatcgagg cgttcgcgat
    10801 gcaaggcgaa caggagcgcg gaggcgagtc gcgtcgtcat cgcaacctcg aggtcgagga
    10861 ggtactcgac gaaaatcgtc gaggtcgccc cgtactccgt ccgaacgtcg gtaaagcgag
    10921 cgtcgggagc ctccgtcggg tggtggtcga cgatgatcga cggctccagc gagagcggtg
    10981 cctccgtgtt cccgccgggt cgcgagtggt cgacgaacgc gacgcagccg gcgtcctcga
    11041 ttctgcgctc gtccccgagt tcgtcgaacg cgacgacgtc gatctcgagc atgttcacga
    11101 acgcgcggtt ttgctggtgg gagatctctc cgccgtagac gatcaggacg tcgtcgacgt
    11161 cgcgcgatcg agcgatccgc tcgagcgcga gcgcactcgc gagacagtcc ggatcggggt
    11221 tgtcgtggca gacgattacc agcgcactcg cctcgtccag caccgacgcg agcgtcgcgg
    11281 ctcgagacat actcgagact acgggtagca acggcttgaa ccccgtgacg ggattcggta
    11341 agtgagagtg tgagtgtccg atcgaatcac tcttcgaccg taatcgagag ctcggcgatc
    11401 aacggagtcg cgatgtgggt tccagtcccg acctgtgcga cgaggtcgtg gtcgcccggt
    11461 tcgagttcga gttcgatcga ggacgagcca ccgccgaagt ggttgtagcc gtcctcgctc
    11521 gggatcagct caccgacctc gaccgggtcg tgatcgacga ggacgtggtg gtgacccgcg
    11581 ttctgatgtg tctgattggc ccgttcgatc tcgaaatcgg ctccatcgac ctcgacctcg
    11641 aggtcgaacg agaccggact cgagaccgtt tcgccgtcct cgataccgac gaactcgagg
    11701 ctcgcctcct cgaccgtgat ggtcacctcg tcggtcaccg gcagggcgcg gtgctggccg
    11761 tcgccggctt gga
//
