LOCUS       NZ_CP119144            10870 bp    DNA     linear   CON 22-NOV-2023
DEFINITION  Streptomyces noursei strain C27 chromosome, complete genome.
ACCESSION   NZ_CP119144
VERSION     NZ_CP119144.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces noursei
  ORGANISM  Streptomyces noursei
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 9627936)
  AUTHORS   Go,B. and Lu,Y.
  TITLE     Control effect and mechanism of Streptomyces NK27 against gray mold
            of grape
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 9627936)
  AUTHORS   Go,B. and Lu,Y.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-FEB-2023) State Key Laboratory for Biology of Plant
            Diseases and Insect Pests, Institute of Plant Protection, Chinese
            Academy of Agricultural Sciences, Yuanmingyuan, Beijing 100193,
            China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 01-OCT-2021
            Assembly Method                   :: ABySS v. 2.3
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 98x
            Sequencing Technology             :: Complete Genomics
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 11/22/2023 14:00:30
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,442
            CDSs (total)                      :: 8,348
            Genes (coding)                    :: 8,203
            CDSs (with protein)               :: 8,203
            Genes (RNA)                       :: 94
            rRNAs                             :: 7, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 145
            CDSs (without protein)            :: 145
            Pseudo Genes (ambiguous residues) :: 0 of 145
            Pseudo Genes (frameshifted)       :: 46 of 145
            Pseudo Genes (incomplete)         :: 121 of 145
            Pseudo Genes (internal stop)      :: 12 of 145
            Pseudo Genes (multiple problems)  :: 30 of 145
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 16:17:19
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 9462372
            Orig. end                         :: 9473242
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP119144.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..10870
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="butyrolactone"
                     /region_number="43"
                     /rules="AfsA"
                     /tool="antismash"
     cand_cluster    1..10870
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="AfsA"
                     /kind="single"
                     /product="butyrolactone"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10870
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:5870](+)"
                     /cutoff="20000"
                     /detection_rule="AfsA"
                     /neighbourhood="5000"
                     /product="butyrolactone"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..5870
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="AfsA"
                     /neighbourhood="5000"
                     /product="butyrolactone"
                     /protocluster_number="1"
     gene            154..795
                     /locus_tag="P0D74_RS41435"
     CDS             154..795
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003971431.1"
                     /locus_tag="P0D74_RS41435"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="MBL fold metallo-hydrolase"
                     /protein_id="WP_275467842.1"
                     /transl_table=11
                     /translation="MELTKFGHACVRLEKDGRRLVIDPGGLSDPRALEGADAVLVTHEH
                     FDHFSEEVLRRAAAARPGLRIWTNPSVAKGLDGLGTQVATTGDGDAFSAAGFDIRVHGA
                     WHALIHPDVPRIPNIGFQVDEALFHPGDALTVPDGPIGTLLLPVHAPWSTVGDLIDYVR
                     EVAPHTAYAVHDGALNDVGAAMVEGFLGERGPGVPARYQRLAPGATTRIA"
     misc_feature    1093..1108
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 18.75"
                     /tool="antismash"
     gene            1492..2241
                     /gene="cseB"
                     /locus_tag="P0D74_RS41440"
     CDS             1492..2241
                     /GO_function="GO:0000156 - phosphorelay response regulator
                     activity [Evidence IEA]"
                     /GO_function="GO:0000976 - transcription cis-regulatory
                     region binding [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene="cseB"
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016576435.1"
                     /locus_tag="P0D74_RS41440"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="two-component system response regulator CseB"
                     /protein_id="WP_275467304.1"
                     /transl_table=11
                     /translation="MTATPALLDEPAGPHILFVEDDAVIRDTVRIALQRYGFTVSTAAD
                     GLTGLELFRSAHPDLLLLDLMLPQLDGIGLCRRIREFSLAPVLMVTARGDDLDVISGLE
                     AGADDYVVKPCESAVLVARIRSLLRRASFPSLSGEPAREEPARDEGAADARSVLTFGEL
                     TIDTSGMEVRRAGEIVALTPTELRLLLAFAESPGVVLERRTLLRKVWDHTWDGDMRVVD
                     LHVKRLRAKVDAERIETVRGFGYKLRR"
     gene            2343..3560
                     /locus_tag="P0D74_RS41445"
     CDS             2343..3560
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1003: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016576434.1"
                     /locus_tag="P0D74_RS41445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="HAMP domain-containing sensor histidine kinase"
                     /protein_id="WP_317623442.1"
                     /transl_table=11
                     /translation="MTVIVLEILVDRASHAFTLEQSRSITMLTLDRAAVSYSRTGLVAG
                     TGAELDATEVPGKLRALVRQGRQGTEYTDGPDGPAMWAARRAGTRTLSVRHSLRTTLGD
                     LEGFNRSILRAGLLTILVVLPPIWLVTGEMSRRLRTAAGTARRIAAGDLDARISAMPRP
                     FDEIAEISGAVDSMAASLQARLRSEQRFTADVAHELRTPLMGLVTAAELLPDGEAERYV
                     RDRVRALCALVEDLLEISRLDAGVERADPQHCALVPLLEETVERVAVPATVLVGGPTNP
                     ADVRVWTDPRRLERIVANLVVNAHRHGRPPVAVTVGVDADTGVPTVSVRDRGPGFPTGL
                     LDDGPQRFRTGARERGKGHGLGLTIALGQAHVIGATLTFGNAPDGRGAVALVRLPRGPA
                     ADPIRD"
     gene            3714..4934
                     /locus_tag="P0D74_RS41450"
     CDS             3714..4934
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016576433.1"
                     /locus_tag="P0D74_RS41450"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="cytochrome P450"
                     /protein_id="WP_275467306.1"
                     /sec_met_domain="p450 (E-value: 8.9e-15, bitscore: 53.3,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNAKTTHGAREETVVDLAAYGAQFVENPYPVYAELRAKGPVHRVR
                     VPGQERDFWLVVRNEEGRRILADERLSKDWRSQGVWPADALPINENMVESDPPKHTRLR
                     ALVTRAFTARRIEALAPRVHTLTADLLDAMSKAPNGRADLVAALAFPLSMTVICELLGV
                     PDLDRQSFRQWTNEIVASSSPEATAEAVRAVNAYLTGLIEQKRAEPRDDLLSALLRTTD
                     EEGDRLSPEEVVGMAFLLLAAGHETTVGLISNTVLALLRHPDQLTLLKADFSLIGNAVE
                     ETLRYDSPTENSTYRFATEAMDFCGARFEKGDPVLVSLAAAGRDGERFEDGERFDITRS
                     ARGHLSFGHGIHYCLGAPLARLEAGVAVRALLERCPDLRLDTSEPLVYIPGMLVRGVRR
                     LPVRWTG"
     misc_feature    complement(3715..3729)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 16.93"
                     /tool="antismash"
     gene            5001..5870
                     /locus_tag="P0D74_RS41455"
     CDS             5001..5870
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     butyrolactone: AfsA"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF015700.3"
                     /locus_tag="P0D74_RS41455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="AfsA-related hotdog domain-containing protein"
                     /protein_id="WP_275467307.1"
                     /sec_met_domain="AfsA (E-value: 1.9e-10, bitscore: 39.6,
                     seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTDTVNPAHDTARGPISETAKISTDDTHTFFFDHPLDHIPGMLL
                     VDTALHRAEQAAGRHAAGPLRVQDLDLTFNGLCEHGSEALVHLRESQPDSRTFSLDVRQ
                     DGTSVCTGSLRLEPAPRRELFVEPPGQAPGHDRPRRASAELVHKRSLDNVLIGPLRQTG
                     EHSYTTVMIAPPADRWPDVHPTTVLVEAIRQTATITSHTAWDIPTDWQYILMSIRLTLT
                     DTATWPAAPELICQVSPLKGRARGGIDIAVQVDGTRVGHMHLKARAVPPAAYQRMREAS
                     AKTAEATA"
     gene            5867..6514
                     /locus_tag="P0D74_RS41460"
     CDS             5867..6514
                     /EC_number="2.1.1.100"
                     /EC_number="2.1.1.334"
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF016107.3"
                     /locus_tag="P0D74_RS41460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="isoprenylcysteine carboxylmethyltransferase
                     family protein"
                     /protein_id="WP_275467308.1"
                     /transl_table=11
                     /translation="MRRWITEKFPALFFFTGLLAGVGALVRAARDTGSPAFPMPAVMIG
                     VYLCWVLLEARITFRTARMQDTEDDHGTEILYGLSRFATVLAALYGPLPDTPPLLAAGP
                     LLVLLAGIALRLLSIRTLGAFYSHRVRTDAQHRVATSGPYRLLRHPAYAGMILAHIGLV
                     AYFLNPLSVALLLLLFVPAVVRRISVEEKVMSTVAGYRDFMASRKRLVPFLW"
     gene            6511..7515
                     /locus_tag="P0D74_RS41465"
     CDS             6511..7515
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RmlD_sub_bind"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010: NAD-dependent epimerase/dehydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF013530.3"
                     /locus_tag="P0D74_RS41465"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="NAD-dependent epimerase/dehydratase family
                     protein"
                     /protein_id="WP_275467309.1"
                     /sec_met_domain="RmlD_sub_bind (E-value: 0.00012, bitscore:
                     20.2, seeds: 37, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTEAPRTGRLPRIALTGATGYVGRALLRHLSGMASPWPVTALVRQ
                     PPPRRLPFVTYVQGEIPGRLPAGFPPPGTDVLIHLANENRSRDQDLLHAVNVAGTRALI
                     GAAPDSLKGVLLGSSLSVYGRGAQIRVAETAPARPSTSLAHARLGAEREVAEAMRQRDA
                     TAYLLRPRFITGRDDTSFLPGISKLRRLPLRVPADRTHFSLIDVDDYGSVIAQLARRVL
                     ERAAAGTPVRTALNVAYRRPVTLRDLFDLLAAPPSPGPLRWLPAAPVRAVSSVLPGQGA
                     SRLAEQLDLVTRSHWADVGLLESEIGTALTAKSPETVVRSYRAHQPQPEQGNS"
     gene            7512..10214
                     /locus_tag="P0D74_RS41470"
     CDS             7512..10214
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016301 - kinase activity [Evidence IEA]"
                     /GO_process="GO:0016310 - phosphorylation [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PPDK_N"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF013491.3"
                     /locus_tag="P0D74_RS41470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="PEP/pyruvate-binding domain-containing protein"
                     /protein_id="WP_275467310.1"
                     /sec_met_domain="PPDK_N (E-value: 1.9e-54, bitscore: 184.0,
                     seeds: 105, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNETLIETLDDGMTPNSVGWKFARLKTLQERGVRVPGLFCLTGAA
                     YHRAVAPVADAIDSLVRNTDLDDWDQVCATSARIREVVAQAGLGPEVEPALERRLAADF
                     PDGPLLAVRASVIGALGQGEDSARNPFAGMSDSFLYVPPSGVKEAVLKCWASAFSPEGL
                     LYRHRQGLPFSGLSVAVGVQRMVFGERSLVLFTCDPTSYARNTVISASWGIGEGVVQEK
                     APVDHYFVHSRTGNVESVVARKTTMVTLDRERGHGTVETAVASERVDVPVLSDEEARSL
                     AALGRDIEKIFGEPQDIEATFTEDGLVHVVQSRPVTIEADRHRIWSSANVSESFPDTTT
                     PMTYSVARRFYWLLNHDYLRRSGVPESELHDLHETMTRLLGFLDNRIYHSINAFIHMLS
                     AVPMFDSVRRDWERLVAELDTFYHHTSDKPTGFRARGRRAVRLVTGWGRVARAYQTLPR
                     DFKDFQEQWSGLLREVRTGATASEHPLKLVADYRHTWRTAGRLWGITLVNYQFMVLFHK
                     AVELTMDRWGVDEQETLFSQLLCGGRQLKGAEIALSAVRLAERVRADAGLHDVFLADQP
                     RAIWDRLEAGKLPREFTEEVRRHIEGYGDRGIAELKLEKSNLRDTPWELIRLVQQYAAS
                     DLTVADMEEVERETRLAGEALLRSKLPRARLRRAVLLGLFDRLRTTLYYREVGRYMRSE
                     LFGYSKQVIRALGAELHRRDVLGDPEDVFFLDLDELFGFVDGTGSTRDLAGLVAVRRRD
                     LEKSRALRPVREFATGDVVATSVPQQEDVSPDGTEGVEGLRGLGSCPGKVRGYARVLSD
                     PALDGEFPADSILITRETDPGWLYLMLASKGIVVERGSLLSHTAITGRKFGIPTIVGVP
                     DATRRIPEGSLIEVDGGTGSVVILDEAPR"
ORIGIN
        1 tcgtacggcc cggaccagct caccgagtga ccgccgcagc tcctcgccca gcgcttcttc
       61 gttcatgggg ccatcttagt catagttgtg ccacctagtt gtacagtcag gttgtagaaa
      121 ttggttggat ggagacggaa gggcgtgtcg gccatggaac tcaccaagtt cggtcatgcg
      181 tgtgtgcggc ttgagaagga cgggcgccgc ctggtcatcg acccgggcgg cctgagtgac
      241 ccgagggcgt tggaaggcgc cgacgccgtg ctcgtgacgc acgagcactt cgaccacttc
      301 tcggaggagg tgctgcgccg ggcggccgcg gcgcgtccgg ggctgcgtat ctggaccaac
      361 ccctccgtcg cgaagggtct ggacggcctc ggcacgcagg tcgccaccac cggagacggc
      421 gacgccttca gtgccgcagg ctttgacatc cgggttcacg gggcctggca cgcgctcatc
      481 cacccggatg tcccgcgcat ccccaacatc ggtttccagg tggacgaggc cctcttccat
      541 cccggcgacg ccctgaccgt ccccgacggt ccgatcggaa cgctgctgct gcctgtgcac
      601 gctccctggt ccaccgtcgg cgatctgatc gactacgtgc gcgaggtcgc tccccacacc
      661 gcctacgccg tgcacgacgg tgccctcaac gacgtgggcg ccgcgatggt cgagggcttc
      721 ctcggcgagc ggggccccgg ggtcccggcc cgctaccaac ggctcgcccc gggcgcgacc
      781 acccggatcg cctgaggtcc ggcgctgccg gcaacggcgg cgccgcacct gccggtccga
      841 ttccccacca ccgttccgcg ggctcacgca cctggcgggg aggctgtgag gccgcgcccg
      901 ggcatctgtc cgttatgccc aaaaggggtc gctatcgtgt cgccgatgca tgccatcgat
      961 ccggccaccc gcctgcgatg ccggacgtgg cctcgcgggt ccgaatgact gcggcttctc
     1021 ctaatttcgg atgtgttatt cgggcccagg ggcgcagtgg tggcaaccgc taggctcctt
     1081 gtcaatgcgc tcttcacgct tcgtacacac acgcgcgggc gcggcgcggt ctcgaaggga
     1141 cgacgaccgc cgccggtcac tgtcgtgcgg agccgggctg ggcagggccg tttccctcac
     1201 ggccatcact gccctcatgg ccgtcgcagc gatcgtgttg agcgtggccg tggccggata
     1261 cgcgtccgac acaggggtac gggacgcggg cacgacgacg gatctgccgc agccggcggg
     1321 cacgttcccg tcggggccgg accggacgcc ccccgaacgt cctcccgtcg agggggcaaa
     1381 gcggcgtcca ccccgtgccg atgccgttct cctccggtac ggcgcgccca ggcaccttcc
     1441 ggccttcgcc ggcgtcttgc catccctcac cggaacagcg aggacattgc catgaccgcc
     1501 acccccgccc tcctcgacga acccgccggt ccgcacatcc tgttcgtgga ggacgacgcg
     1561 gtgatccggg acaccgtccg catcgcgctc cagcgttacg gcttcaccgt ctccaccgcg
     1621 gccgacggcc tcaccggcct cgaactcttc cggagcgcgc acccggatct gctgctgctc
     1681 gacctcatgc ttccgcagct cgacggcatc ggactgtgcc ggaggataag ggagttcagc
     1741 ctcgcgccgg tcctcatggt gaccgcgcgc ggcgacgacc tggacgtgat ctccgggttg
     1801 gaggcgggcg cggacgacta tgtggtcaag ccgtgcgaga gcgcggtgct cgtcgcgcgc
     1861 atacggtcgc tgctgcgccg cgcctccttc ccgtccctgt ccggggagcc cgcacgcgaa
     1921 gaacccgcac gcgacgaggg cgcggcggac gcccggtccg tcctcacctt cggggaactg
     1981 accatcgaca cctccggaat ggaggtgcgg cgcgcggggg agatcgtggc gttgaccccc
     2041 acggagctgc gactgctgct ggcgttcgcc gagtcgccgg gcgtcgtgct ggagcgcagg
     2101 acgctgctga ggaaggtgtg ggaccacacc tgggacggcg acatgcgcgt ggtcgacctg
     2161 catgtgaagc ggctgcgtgc caaggtcgac gccgaacgga tcgagaccgt acgcggcttc
     2221 ggatacaagc tgcggcgctg acgatgcctc cgcacccgtc gtcctctccg aggacctggt
     2281 cgtggtatcc ctcacggtcc ttgcggtggc gcatcgcggg actggtggcc gcggcgacct
     2341 gtgtgaccgt catcgtcctg gagattctgg tcgatcgtgc ctcgcacgcc ttcacgttgg
     2401 aacagtcccg ctcgatcacc atgctcacgc tcgaccgtgc cgccgtgtcc tactcgcgca
     2461 cgggcctggt cgccggaacc ggcgccgaac tcgacgcgac cgaggtgccc ggaaagctgc
     2521 gggcgttggt acgccagggg cgtcagggca ccgagtacac ggacggtccc gacggtcccg
     2581 ccatgtgggc cgcccgccgc gccggcacac gcaccctgtc ggtacggcac tcgttgcgca
     2641 ccacgctggg cgacctggaa ggcttcaaca ggtccatcct gcgggccggc ctgttgacga
     2701 tcctcgtcgt gctgccgccc atctggctcg tcaccgggga aatgagtcgc cggctgcgaa
     2761 cggccgcggg caccgcccga cggatagccg ccggtgacct ggacgcccgg atctccgcga
     2821 tgccccgccc gttcgacgag atcgccgaga tctccggtgc cgtcgactcg atggcggcct
     2881 ccctccaggc gcgactgcga agcgaacagc gcttcaccgc ggatgtcgcc catgaactgc
     2941 gcacgcccct gatggggttg gtcaccgccg ccgaacttct cccggacggt gaggcggaac
     3001 gctacgtgcg ggaccgagtg cgtgcgctgt gcgcgctggt cgaggatctg ctggagatct
     3061 ccagactcga cgcgggcgtg gagcgcgcgg acccgcagca ctgcgcgctg gtgccgctgt
     3121 tggaggagac cgtggagcgg gtcgcggttc cggcgacggt gctcgtcggg ggccccacca
     3181 acccggcgga cgtacgcgtg tggaccgacc cccgcaggct ggagcgcatc gtcgccaacc
     3241 tcgtcgtcaa cgcgcaccgg cacggccgtc cgcccgtggc ggtcacggtg ggggtggacg
     3301 ccgacaccgg cgttcccacc gtgtccgtac gggaccgggg gcccggcttt cccaccggac
     3361 tgctggacga cggccctcag cggttccgga ccggcgcccg tgaacgcggc aagggacacg
     3421 gactcgggct gaccatcgcg ctcgggcagg cccacgtcat cggcgccact ctgacgttcg
     3481 gcaacgcacc ggacggcaga ggcgccgtgg ccctcgtacg gcttccccgc ggcccggcgg
     3541 cggacccgat acgcgactga cacaccgccg accccggacg gacgtaccgc tgacacgccg
     3601 tcgcggcaca gccgagccgg ccccgacctc tctcctacct caggacgaca cattcgcttc
     3661 gcaggatggc acccgcacct gaactgacga cgttccaggg aaggactgcc gcaatgaacg
     3721 cgaagaccac ccacggcgcg cgggaagaga ccgtggtcga cctcgccgcg tacggcgcgc
     3781 aattcgtcga gaacccctat cccgtctacg cggagctacg cgcgaaagga ccggtgcacc
     3841 gggtccgtgt ccccggtcag gagcgggact tctggctggt cgtccgcaac gaggagggcc
     3901 gccgcatcct cgccgacgag cgcctcagca aggactggcg ctcccaaggg gtctggccgg
     3961 ccgacgcgct gccgatcaac gagaacatgg tggagagcga tccccccaaa cacacgcgcc
     4021 tgcgcgccct ggtgacccgc gcgttcaccg cgcgccgcat cgaggcactg gctccccggg
     4081 tccacacgct gaccgcggat ctcctggacg cgatgtccaa ggcccccaac gggcgggccg
     4141 acctggtcgc cgccctcgcc ttcccgctct ccatgacggt gatctgcgag ctgctcggcg
     4201 tgccggacct ggaccggcag tcgttccggc agtggaccaa cgagatcgtg gcttcctcct
     4261 cgcccgaggc gaccgccgag gccgtgcggg cggtcaacgc ctatctcacc ggcctcatcg
     4321 agcagaagcg cgcagagccg cgcgacgacc tgctgagcgc actgctgcgc acgaccgacg
     4381 aggaggggga caggctgagc ccggaagaag tcgtcggcat ggccttcctg ctgctcgcgg
     4441 ccgggcacga gaccaccgtc ggcctgatct cgaacaccgt gctggcgctg ctccgccacc
     4501 ccgaccaact cacgctgctg aaggccgact tctccctcat cggcaacgcg gtcgaggaga
     4561 cactgcggta cgacagcccg acggagaact ctacctaccg gttcgccacc gaggccatgg
     4621 acttctgcgg cgcccgcttc gagaagggcg atccggtgct ggtgtcgctc gccgcggccg
     4681 ggcgggacgg cgaacgcttc gaggacggcg aacgcttcga catcacccgc agcgcgcgcg
     4741 gacacctctc cttcggccac ggcatccact actgcctggg cgccccgctg gcccggctcg
     4801 aagccggcgt cgcggtccgg gccctgctgg agcgctgccc cgatctgcgc ctcgacacct
     4861 ccgaacccct cgtgtacata ccggggatgc tcgtccgcgg cgtgcgccgg ctgccggtgc
     4921 gatggaccgg gtgaccccgt gaccgcaccg aaccctcaac tccccgtccc gagcaccccg
     4981 agcacacccc ggagcactcc atgagtaccg acacggtgaa cccggcgcac gacacggccc
     5041 gcggcccgat cagcgaaacc gccaagatca gcacggacga cacccacacg ttcttcttcg
     5101 accaccccct cgatcacata ccgggcatgc tgctcgtgga caccgccctg caccgggcgg
     5161 agcaggccgc cggccggcac gccgcaggtc cactgcgggt ccaggacctc gatctgacgt
     5221 tcaacggcct gtgcgagcac ggttccgagg ccctcgtcca cctcagggag agccagccgg
     5281 acagccgcac gttcagcctg gacgtacgcc aggacgggac gagcgtctgc accggatcgc
     5341 tgcggctgga gccggctcca cggcgggagc tcttcgtcga accgccagga caggcaccgg
     5401 gacacgaccg cccgcggcgc gcgtccgcgg agctggtcca caagaggtcc ctggacaacg
     5461 tcctgatcgg gccgctgcgg cagaccggcg agcacagcta caccaccgtc atgatcgctc
     5521 cgcccgccga ccgatggccc gacgtgcatc ccacgaccgt gctggtggag gcgatccggc
     5581 agaccgcgac catcacctcc cacaccgcgt gggacatccc cacggactgg cagtacatcc
     5641 tgatgtcgat ccgcctgacg ctcaccgaca ccgcgacctg gcccgccgcc cccgaactca
     5701 tctgccaggt cagcccgttg aagggccgcg cccgcggtgg gatcgacatc gccgtccagg
     5761 tcgacgggac acgggtcggc cacatgcacc tcaaggcccg cgccgtacct cccgccgcgt
     5821 accaacggat gcgtgaggcc agcgcgaaga cggcggaggc gacggcatga ggcgctggat
     5881 caccgagaag ttcccggcac tcttcttctt caccgggctc ctggccggcg tcggcgccct
     5941 cgtccgggcg gcgcgggaca ccgggagccc cgccttcccg atgccggcgg tgatgatcgg
     6001 cgtctacctg tgctgggtcc tgctggaggc gcgcatcacc ttccgcacgg ccaggatgca
     6061 ggacaccgag gacgaccacg gcacggagat cctctacggg ctgtcacggt tcgcgaccgt
     6121 cctcgccgcg ctctacggcc cgctgcccga cacgccgccg ctcctggcgg ccggcccgct
     6181 gctggtcctg ctggccggaa tcgcgctgcg gctcctctcg atccggacgc tcggcgcctt
     6241 ctactcgcac cgggtgcgca cggacgccca gcaccgcgtc gccacctccg gaccgtaccg
     6301 gctgctcaga cacccggcct acgcgggaat gatcctcgcg cacatcgggc tcgtggcgta
     6361 cttcctgaat ccgttgagcg tcgcgctgtt gctgctgctg ttcgtccccg cggtcgtgcg
     6421 caggatctcc gtcgaggaga aggtgatgtc gaccgtcgcc ggctaccgcg acttcatggc
     6481 gagccgcaaa cggctcgtgc cgttcctgtg gtgaccgaag caccgcgcac cggccgactg
     6541 cccaggatcg ccctgaccgg ggccaccggt tacgtgggcc gcgcgttgct gcggcacctg
     6601 tcgggaatgg cctcgccctg gccggtcacg gcgctggtcc ggcaaccgcc gccgcgacgg
     6661 ctgccgttcg tcacctacgt gcagggcgag atcccggggc ggctgcccgc cggcttcccg
     6721 ccgcccggca ccgacgtgct gattcacctc gccaacgaga accgcagccg cgaccaggac
     6781 ctcctgcacg ccgtgaacgt ggcgggcacc cgagccctga tcggcgcagc ccccgactcc
     6841 ctgaagggcg tactgctcgg cagctccctg tccgtctacg gcaggggcgc tcagatccgg
     6901 gtggcggaaa cggcgcccgc ccggccgtcg acgtccctgg cccacgcccg gctgggcgcc
     6961 gagcgcgagg tcgccgaggc catgcggcag cgcgacgcaa cggcctacct gctgcggccg
     7021 cggttcatca ccggccggga cgacacctcg ttcctgcccg gcatcagcaa gcttcggcgg
     7081 ctgccgctgc gggtgcccgc cgaccggacc cacttcagcc tgatcgacgt ggacgactac
     7141 ggctcggtga tcgcgcagct cgcgcgccgg gtgctggagc gtgccgcggc cggcacgccc
     7201 gtccgcacgg cgctgaacgt cgcctaccgc agacccgtga ccctgcgcga cctgttcgac
     7261 ctcctggcgg ccccgccgag ccccggcccc ctccgctggc tgccggccgc tccggtacgg
     7321 gccgtgagtt ccgtgctccc cgggcaaggg gcgtcccggc tcgcggagca actcgacctg
     7381 gtcacccggt cccactgggc cgacgtcggc ctcctggaga gcgagatcgg aaccgcactg
     7441 accgcgaaat caccggaaac ggtggtgcgc tcctaccggg cgcaccaacc ccaacccgaa
     7501 cagggaaact cgtgaacgag actctcatcg agacactcga cgacggcatg accccgaaca
     7561 gcgtcggctg gaagttcgcc cggctcaaga ccctccagga gcggggtgtt cgggtcccgg
     7621 gactgttctg cctcaccggc gcggcctacc accgggcggt ggcaccggtc gcggacgcca
     7681 tcgactccct ggtgcgcaac accgacctgg acgactggga ccaggtgtgc gccaccagcg
     7741 cccgcatccg tgaggtcgtc gcccaggccg gactcggccc cgaggtggag ccggccctcg
     7801 aacgccggct ggccgccgat ttccccgacg gtccgctgct ggcggtgcgg gcctcggtca
     7861 tcggcgccct gggccagggc gaggactcgg cacggaaccc gttcgcgggc atgagcgaca
     7921 gcttcctgta cgtcccaccg tccggggtga aggaggcggt gctcaagtgc tgggcatcgg
     7981 cgttcagccc cgaggggctg ctctaccggc accgtcaggg gctgcccttc tccgggctgt
     8041 ccgtcgccgt cggcgtccag cgcatggtct tcggcgagcg ctcgctcgtg ctgttcacct
     8101 gcgaccccac cagctacgcg cgcaacacgg tgatcagcgc aagctggggc atcggcgagg
     8161 gcgtcgtcca ggagaaggcc cccgtcgacc actacttcgt gcactcgcgc accgggaacg
     8221 tcgagagcgt cgtggcccgc aagacgacca tggtgaccct cgaccgcgag cggggacacg
     8281 gaaccgtcga gaccgccgtg gcgagcgaac gcgtcgacgt tcccgtactg agcgacgagg
     8341 aggccaggtc gctggccgca ctcggccgcg acatcgagaa gatcttcggc gagccgcagg
     8401 acatcgaggc gaccttcacc gaggacggtc tcgtgcacgt ggtgcagtcg cgacccgtga
     8461 cgatcgaggc cgaccggcac cggatctgga gcagcgccaa cgtgtccgag agcttcccgg
     8521 acacgacgac cccgatgacg tactcggtgg cgcgccgctt ctactggctg ctgaaccacg
     8581 actacctgcg ccgcagcgga gtccccgaga gcgaactgca cgatctgcac gagacgatga
     8641 cccggctgct cgggttcctg gacaaccgca tctaccacag catcaatgcc ttcatccaca
     8701 tgctgtccgc cgtgccgatg ttcgacagcg tccggcgcga ctgggaacgc ctcgtcgccg
     8761 aactcgacac gttctaccac cacacgtccg acaagcccac gggctttcgc gcccgcggtc
     8821 gccgggcggt ccgactggtc accggatggg gcagggtggc gcgtgcgtac cagaccctgc
     8881 cccgcgactt caaggatttt caggagcagt ggagcgggct gctgcgggag gtgcggaccg
     8941 gggcgacggc gagcgaacat ccgctcaagc tcgtcgccga ctaccggcac acctggcgca
     9001 cggcgggacg gctctggggc atcaccctcg tcaactacca gttcatggtc ctgttccaca
     9061 aagccgtcga gctgaccatg gaccgctggg gcgtcgacga gcaggagacc ctcttcagcc
     9121 agttgctgtg cggcggccgg cagctcaagg gcgcggaaat cgccctgagc gcggtacggc
     9181 tggccgagcg ggtgcgcgcc gacgcgggac tgcacgatgt gttcctggcc gaccaaccac
     9241 gcgcgatctg ggaccgcttg gaggcgggga agcttccacg cgagttcacc gaggaagtgc
     9301 gccggcacat cgaggggtac ggcgaccgcg gcatcgcgga actgaagctg gagaagtcca
     9361 acctccgcga cacgccgtgg gagctgatcc gcctcgtcca gcagtacgcc gcgagcgacc
     9421 tgaccgtcgc ggacatggaa gaggtggaac gggaaacgcg cctggcgggc gaggcactgc
     9481 tgcgctccaa actccctcgg gcccggctgc ggcgcgcggt gctgctcggt ctgttcgacc
     9541 ggctgcgcac caccctgtac taccgcgaag tcggccggta catgcgcagt gagctgttcg
     9601 gctacagcaa gcaggtcatc cgcgccctgg gtgcggagtt gcaccgccgc gacgtgctcg
     9661 gcgacccgga ggacgtgttc ttcctcgatc tcgacgagct cttcggcttc gtggacggta
     9721 cgggctccac ccgcgacctg gcgggactgg tcgcggtcag gaggcgcgac ctggagaagt
     9781 cccgggcgct acggccggtg cgcgagttcg ccaccggcga cgtggtggcg acgtcggtgc
     9841 cgcagcagga ggacgtgtcg ccggacggca cggagggcgt cgagggactg cgcggcctcg
     9901 gctcgtgccc gggaaaggtc cgcggatacg cgcgtgtcct gtcggacccg gccctggacg
     9961 gggagttccc cgccgacagc atcctcatca cccgggagac cgatcccggc tggctctacc
    10021 tcatgctcgc ctcgaagggc atcgtcgtcg aacgcggcag cctgctgtcg cacaccgcca
    10081 tcaccggcag gaagttcggc ataccgacga tcgtgggggt gccggacgcg acccggagga
    10141 tccccgaggg gagcctcatc gaggtcgacg gaggcaccgg cagcgtcgtg atcctcgacg
    10201 aggccccccg gtgaggccgc tgcgcgcctt ctggcggttc ttctcccggc gcttccccgc
    10261 cctgcgctac ctggcgtacg tcgtgctgtg gccggcgggc gtgctgggcg cgctggcgcc
    10321 gttgcgtccc gccggggcgg cggtgggccc tggcgtcgcg aagcaggtgt gcgccgcgct
    10381 ggccctgttc gtgatcctgt tcttcatgcg cgcggtcgac gaggtcaagg acctcgacta
    10441 cgaccgggag ttccaccccg accgtcccct cgtgaccggc gagacggatg ccgcgacgat
    10501 ccgtttctac ctggcggggg cggcggcggc cgccgtggca ctgagcgccg tcgtcggtcc
    10561 ggcggccgtc gtgacgggcg tggcgatcat ggcctacagc gtgttcctgc tcctgctgga
    10621 gaggacgtcc gagcgcttcc gcgagagcgt ctgggggaac atcgccgtca cgatccagct
    10681 caagaccgga ctgatctgct acctggcgct gctggccgcc tccggcggca ccggaacgcc
    10741 gccgctgccg accgcgctcg tggtgctgtc cttcctcctg gcctatctgc actgggagat
    10801 cgcgcgcaag acggtacggg cgcgattcgc cttgcccggc gagaagctct actcgacggc
    10861 gtgcggcgcc
//
