LOCUS       NZ_CP119144            21077 bp    DNA     linear   CON 22-NOV-2023
DEFINITION  Streptomyces noursei strain C27 chromosome, complete genome.
ACCESSION   NZ_CP119144
VERSION     NZ_CP119144.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces noursei
  ORGANISM  Streptomyces noursei
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 9627936)
  AUTHORS   Go,B. and Lu,Y.
  TITLE     Control effect and mechanism of Streptomyces NK27 against gray mold
            of grape
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 9627936)
  AUTHORS   Go,B. and Lu,Y.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-FEB-2023) State Key Laboratory for Biology of Plant
            Diseases and Insect Pests, Institute of Plant Protection, Chinese
            Academy of Agricultural Sciences, Yuanmingyuan, Beijing 100193,
            China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 01-OCT-2021
            Assembly Method                   :: ABySS v. 2.3
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 98x
            Sequencing Technology             :: Complete Genomics
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 11/22/2023 14:00:30
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,442
            CDSs (total)                      :: 8,348
            Genes (coding)                    :: 8,203
            CDSs (with protein)               :: 8,203
            Genes (RNA)                       :: 94
            rRNAs                             :: 7, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 145
            CDSs (without protein)            :: 145
            Pseudo Genes (ambiguous residues) :: 0 of 145
            Pseudo Genes (frameshifted)       :: 46 of 145
            Pseudo Genes (incomplete)         :: 121 of 145
            Pseudo Genes (internal stop)      :: 12 of 145
            Pseudo Genes (multiple problems)  :: 30 of 145
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 16:17:19
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 9002818
            Orig. end                         :: 9023895
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP119144.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..21077
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene-precursor"
                     /region_number="38"
                     /rules="(PT_FPPS_like and not PT_HPP)"
                     /tool="antismash"
     cand_cluster    1..21077
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_FPPS_like and not PT_HPP)"
                     /kind="single"
                     /product="terpene-precursor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21077
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11077](+)"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11077
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
     gene            complement(227..844)
                     /locus_tag="P0D74_RS39255"
     CDS             complement(227..844)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003951576.1"
                     /locus_tag="P0D74_RS39255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="TOPRIM nucleotidyl transferase/hydrolase
                     domain-containing protein"
                     /protein_id="WP_275466920.1"
                     /transl_table=11
                     /translation="MADMKAFRDAVTKWATGGPDRPARDLAEGLGVRTAVLVEGLSDLA
                     AVEALAARRGRDLAADGVCVMPMGGAMSVARYAGLLGPPGLGLRLTGLCDEGERGFYER
                     GLTRAQAPLQDVYVCAADLEDELIRALGTVGVEEILSAEGDLRAWQTFQRQPAQHGRPR
                     HQQARRFLGTKKGRKIRYGRLLVEALAPDRTPPPLDRLLASL"
     misc_feature    983..1000
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 15.36"
                     /tool="antismash"
     gene            1091..1777
                     /locus_tag="P0D74_RS39260"
     CDS             1091..1777
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009717029.1"
                     /locus_tag="P0D74_RS39260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_275466921.1"
                     /transl_table=11
                     /translation="MRSSTTARIARSRSLRVGAAALTAAAGLSLVAWSGSGSADAKPAG
                     RTSASASVADASPAGWSGLQSVGAKASLTGEHSGGTRASTAKSASPVRTQTLVDGSTAR
                     IYDLGGQRYRAEIVSRGAVLATLETTEEEIDAGLDANDMFVVLTMGGEVHSWMGGGQQG
                     PGTFHLAGGWTAKVTKIGELRYRAQIIGHDGSVDATLETKGHDVGLDANGVSIVLSAGG
                     VISAHE"
     gene            complement(1904..3748)
                     /locus_tag="P0D74_RS39265"
     CDS             complement(1904..3748)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003955170.1"
                     /locus_tag="P0D74_RS39265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="FG-GAP-like repeat-containing protein"
                     /protein_id="WP_275466922.1"
                     /transl_table=11
                     /translation="MSVPTEELKLEIVNAATGKPLGAEAAPTADGALVVRDFPDDGPSP
                     EQWQLAPVQAAEGEETEDNQGYVIRNAVTGKVLDDPAAADRAVRQWDAADGNQRQQWHV
                     VPVEGEAGLYFIEGATDGAVLDLDEPGADDTRVVLREHDDGAESQRWRFVPAEPERTSD
                     PALRWAALGHWNGRQSWRLAPSTALRPAPGATPSFSNMLLVLEQFGSDEDAGQWKSEGG
                     TRAPGGQPGWWAGAGARFLADTTGAGRADVVGLKPEEGAVTSSSRGDGTFDDEERVLHP
                     PVPAAGPEDLWTLVDTTGRGKPDVVVLAADGVRVSPQGEDGTFAPAGEPVLKAFGHGEP
                     AGGWLADRHPRFLADTTGDGRLDVVGCHDDGVWVSLQDEEGTFAPIGDEPVLRAFGHDE
                     KAGGWLADKHPRFLGDTTGDGRLDVVGCHDDGVWVSLQDEEGTFADPLYVLDAFGVDQG
                     WGTVEEHPRFLLRTTDGGSLDLVGFGPQGVVVSRGRGDGTFGPAKLVLNDFGPAQGWTS
                     GKHLRFLGDVTGDGNPDVVGFGDEGVWVSHSRGDGTFEQAQLVCSGFGYNEDSGGWRVD
                     RHPRFLADITGDGRVDIVGFGGPGVYVARNLFRRFRTR"
     gene            complement(3816..4535)
                     /locus_tag="P0D74_RS39270"
     CDS             complement(3816..4535)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007497344.1"
                     /locus_tag="P0D74_RS39270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_275466923.1"
                     /transl_table=11
                     /translation="MYTQERTAMSNLVVGGPVAVNSYDNAIVAALLENRPVMLVHAFNG
                     GYLRPAELKEESHDKGVKLATALDPDTKEAQGHLWYITPAGFFGQRPLYVIESAAGQVS
                     PKPAGAGEADAGRGDDGAPKPRRRRITVHQEAPKSTADTVQVGLPDKVGDKWRGRNGAP
                     EDTQLWVVTVTPWGGITFVPITHPDAILGFKDHAVTADSEVRLTYNWGGDFTGTVINTF
                     YPRLPNEWNVPYHHVFT"
     misc_feature    complement(4775..4789)
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 17.65"
                     /tool="antismash"
     gene            4949..6073
                     /locus_tag="P0D74_RS39275"
     CDS             4949..6073
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007453959.1"
                     /locus_tag="P0D74_RS39275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_275466924.1"
                     /transl_table=11
                     /translation="MPSNAYNLERAKRQPLTKKNLRELNIEQTWRSILDHPNLVYVDDY
                     GVRHKPVGFSLNKSSFGAFPGSAFKLGWLAYMNLGEPLIEERRNISQPPPDTFSSRAYV
                     NRSQTSNMTFNDSVEFTVSNEVTWSLQGEAQLTFGGSVGAELQLQLQSQLQVDLQAQFG
                     TELQNQLQNEMANSVENTVTNENSKDDIGVDTANGTTNGVTNSMTNGVTNSASNSVTTS
                     GAFTTTGSATGSAELNAQLMLGITGSVGGSLTTSWASNSQISGEVPPGSRVDTIVTQRR
                     VRKQYSYEIPVTFSGLLAVKYDVPVAVLSPPQSRNHPGLEYVVARDLGDVDLAGGNGFR
                     MKGLAEVVSALEVHHTMFDGESLTGSERELHKQP"
     gene            6117..6632
                     /locus_tag="P0D74_RS39280"
     CDS             6117..6632
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017945163.1"
                     /locus_tag="P0D74_RS39280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_275466925.1"
                     /transl_table=11
                     /translation="MVFGNIFGFADKGAGLFSVTTDGTKPQPGAGVDFEDADDDTYDDT
                     SASLFNNAIHGANSRAKVVQETSPEARAILGFLGSFVQTTQASAGAQAQYAQNPGSVSN
                     AASAGMKESSSTVTEHGDLQKDEDLQSKPKKSDFNQAPKAPPAPEAQTPKASKPTAEDP
                     SASNDNRS"
     misc_feature    6639..6650
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: medium, score: 18.76"
                     /tool="antismash"
     gene            6664..8190
                     /locus_tag="P0D74_RS39285"
     CDS             6664..8190
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009999199.1"
                     /locus_tag="P0D74_RS39285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="RICIN domain-containing protein"
                     /protein_id="WP_275466926.1"
                     /transl_table=11
                     /translation="MSTAHEATTGGEDSAPPISTVAGTGVSGFAGDNGPAVSAQLNNPY
                     GVVVDSTGTLYVSEYNNHRVRKITTDGKISTVVGTDTKGFSGDCGPAASAQLNRPRGVA
                     VDSAGTVYIADSDNHRVRKVAADGKVCTVAGTGTKGFSGDGGPATAAQLDGPYGVAVDS
                     TGTLYVTEHNNRRVRKITTDGLISTVAGTGTKGSDGDGGPALSARLTNPRGVAVGRAGE
                     LYIVDTGSHRVRQVTADGLISAVAGTGTKGFSGDGGPATAAQLDNPFEVTVDSIGTLYI
                     ADFGNNRVRQVTSDGKISTVAGTGTGGSDGDDGPAASAQLNKPIGLAVDRANTLYIADH
                     ANHRVRKVVLAKRAGLPASGTVVSWANVRSRLRMAVQRESTKDGAEIHQTLATPRGHQR
                     WRLVVAGQVDGENLYTIENLRSGKVLEIVGAHETAGAVVAQRAYEGDDAHHQQWRLIPV
                     SSATDTPQVYEIANRNSGLLLRVDTNARTAIQQHRAEGDHRDRQWHLLPV"
     gene            complement(8351..9040)
                     /locus_tag="P0D74_RS39290"
     CDS             complement(8351..9040)
                     /GO_function="GO:0003725 - double-stranded RNA binding
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003963560.1"
                     /locus_tag="P0D74_RS39290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="Sua5/YciO/YrdC/YwlC family protein"
                     /protein_id="WP_275466927.1"
                     /transl_table=11
                     /translation="MSHRPAVDATPATSDTATVHHALAQGRAVVLPNPAPLTCVVTATR
                     PAAVNVAKGRPADQAVALWAHHPHTREELTEHLDLGPDAHRLARRLLTEELVTLLAPLR
                     RPHGVPSWLAPAARDGWTLLFAARWQPLAPLLDDFPLLYVSSANRTGHPPAATPAEAAP
                     HFAPRTPVLTAPTPLAASPRRATTTIRVHPDARTELHRHGAQDHPHPSAEHYLNHLHHT
                     YRTPPTA"
     misc_feature    9086..9101
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 20.33"
                     /tool="antismash"
     misc_feature    complement(9087..9100)
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 17.68"
                     /tool="antismash"
     misc_feature    complement(9195..9208)
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 19.48"
                     /tool="antismash"
     misc_feature    9219..9230
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 16.17"
                     /tool="antismash"
     misc_feature    complement(9357..9373)
                     /note="TFBS match to NuR, Nickel-responsive regulator,
                     confidence: weak, score: 20.72"
                     /tool="antismash"
     gene            complement(9457..9675)
                     /locus_tag="P0D74_RS39295"
     CDS             complement(9457..9675)
                     /GO_function="GO:0005509 - calcium ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018540502.1"
                     /locus_tag="P0D74_RS39295"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="EF-hand domain-containing protein"
                     /protein_id="WP_016576971.1"
                     /transl_table=11
                     /translation="MADIVETAARKVFARYDLDGDGQVTAEEYRQVIAELEGTEITEAQ
                     AQELIDSLDTDGDRQMSFEEFWAAMNG"
     gene            10001..11077
                     /locus_tag="P0D74_RS39300"
     CDS             10001..11077
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene-precursor: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016576972.1"
                     /locus_tag="P0D74_RS39300"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_275466928.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 2.7e-38, bitscore:
                     130.6, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSAEIEAGVHERLAGYRDRFHGLFADYFDSVARQGPPRNAFVPEA
                     LELVRDMSLRGGKRLRVALVYEAARLVTPDAVTGLDEAALSIELLQTHGLIHDDIIDDS
                     PVRRGAPSVYYAYRDRFPDRPHTALGLAVLAGDLAAFLSVQVLLTAPVPRDLRQAMAAV
                     QATAGADTVRGQFLDLERDFGPVPDRAALDTVSEYKSARYSVLAPLQLGLLAAGADVTA
                     HEEELTRYARLLGVSGQMRDDYLDLFADAGTVGKPAGSDLREGRRSYAVCALLAATSGA
                     ERAVVESALAGPGCPPQTVERVQDIARHHGVDEQLLAEIRGGAEEAAAVAATWRGRWRD
                     EAVAFFEQLPLWGALRTQ"
     gene            complement(11230..12393)
                     /locus_tag="P0D74_RS39305"
     CDS             complement(11230..12393)
                     /EC_number="2.4.1.227"
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_function="GO:0050511 -
                     undecaprenyldiphospho-muramoylpentapeptide
                     beta-N-acetylglucosaminyltransferase activity [Evidence
                     IEA]"
                     /GO_function="GO:0051991 -
                     UDP-N-acetyl-D-glucosamine:N-acetylmuramoyl-L-alanyl-D-
                     glutamyl-meso-2,
                     6-diaminopimelyl-D-alanyl-D-alanine-diphosphoundecaprenol
                     4-beta-N-acetylglucosaminlytransferase activity [Evidence
                     IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /GO_process="GO:0007049 - cell cycle [Evidence IEA]"
                     /GO_process="GO:0008360 - regulation of cell shape
                     [Evidence IEA]"
                     /GO_process="GO:0009252 - peptidoglycan biosynthetic
                     process [Evidence IEA]"
                     /GO_process="GO:0030259 - lipid glycosylation [Evidence
                     IEA]"
                     /GO_process="GO:0051301 - cell division [Evidence IEA]"
                     /GO_process="GO:0071555 - cell wall organization [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glyco_transf_28"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glyco_tran_28_C"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016576973.1"
                     /locus_tag="P0D74_RS39305"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="UDP-N-acetylglucosamine--N-acetylmuramyl-
                     (pentapeptide) pyrophosphoryl-undecaprenol
                     N-acetylglucosamine transferase"
                     /protein_id="WP_275466929.1"
                     /sec_met_domain="Glyco_transf_28 (E-value: 2.3e-22,
                     bitscore: 78.4, seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="Glyco_tran_28_C (E-value: 1.4e-30,
                     bitscore: 105.3, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSNVDAFRLVVTGGGTGGHTYPALTAIRALRRRLSAEGRALDVLW
                     IGTADGLEARVAPAEGIPFATVATGKVRRAKNPLKMMSAANIKDMARVPLGVAQARKLV
                     AGFGPDVVLATGGYVAVPTGLAARICRRPLVLHEQTVRLGLANRKLAGSATRIAVSSES
                     SVPLLPERVRGRAVVTGNPIRPEVLAGQPDKAVQSLGLHAFDRGLPTVYVTGGAQGARQ
                     INDVVRDALPWLLQQANVVHQCGPDNVAELRRHAAALPTALAGRYHLTGFVGPELPDVL
                     ALADVVVSRSGAGTLAELTALGKPAVFVPLASAAGNEQAHNAQHLEASGAALALLGDVT
                     AGRLKDAVGPLLTDPALRATMAERARAHGRPDAADRLVEVLMSAASG"
     misc_feature    12376..12389
                     /note="TFBS match to RpoN, Regulator of nitrogen
                     assimilation and virulence, confidence: medium, score:
                     16.73"
                     /tool="antismash"
     tRNA            complement(12556..12629)
                     /anticodon=(pos:complement(9015411..9015413),aa:Met,
                     seq:cat)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="P0D74_RS39310"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /product="tRNA-Met"
     gene            complement(12556..12629)
                     /locus_tag="P0D74_RS39310"
     gene            complement(12840..15437)
                     /gene="rph"
                     /locus_tag="P0D74_RS39315"
     CDS             complement(12840..15437)
                     /EC_number="2.7.9.6"
                     /codon_start=1
                     /gene="rph"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PPDK_N"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016576974.1"
                     /locus_tag="P0D74_RS39315"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="rifamycin-inactivating phosphotransferase"
                     /protein_id="WP_275466930.1"
                     /sec_met_domain="PPDK_N (E-value: 1.7e-93, bitscore: 312.4,
                     seeds: 105, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIERYVWDLRDADEMQGAVVGGKGAHLGGLSRIDGVRVPEGFCVT
                     TDAFRRVMAEAPSIDDQLDQLSRLDPDDREAVRRLSAQVRRTIEGIAVPDDLAAAITRA
                     LGRLGEQAAYAVRSSATAEDLPTASFAGQQDTYLNVMGRTEILRHVSRCWASLFTERAV
                     TYRQRNGIDHRTVRMAVVVQRMAFPHASGVLFTADPVSGNRKVATVDAGFGLGEALVSG
                     LVNPDVFTVRDGEVVAKTIAAKQRAVQALPAGGTQEVAIDAQQQEQPALTDAQVVRLVE
                     LGRRIEAHFGRPQDIEWCLVDDGFRIVQSRPITTLFPVPEAGDEENHVYVSVGHQQMMT
                     DAMKPLGLSMWQLTAMVPMHAAGGRLFVDATRRLSSPAGRAALLDVMGKGDPLVRDALE
                     TVLDRDDFVPSLPDAVPGRPTAGGAPAPIDNDPAVVKELIERSRASVAALERNIRTRTG
                     PELFDFLLEAFDEHKRVLGDPLSVQAIMAGMDATWWLNDKLQEWLGEKNAADTLTLSAP
                     DNITSEMGLALLDVADVIRARPEVVAFLQDVEDEDFLGELAKVAGGAEARDAIEGYLDR
                     YGMRCVGEIDITRPRWRERPTTLVPVLLDNVRNFAPGAAARRFEEGRRKAQEKEEDVLA
                     RLRALPDGDRKADETKRMIDRVRTFIGYREYPKYGIVSRYFVYKQALLAEAQRLVAADV
                     LPAQEDVFYLTFQELHDVVRSHQVDGRLVQQRKDAFRAYQALTPPRVLTSDGEAVTGAY
                     RRDDVPAGALVGLPVSVGTVEGRARVVLDMAEADLEAGDILVTTFTDPSWSPLFVGIAG
                     LVTEVGGLMTHGAVIAREYGLPAVVGVAQATRLIRDGQRIRVHGTDGYVEILP"
     misc_feature    complement(15478..15492)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: strong, score: 19.19"
                     /tool="antismash"
     gene            complement(15861..16523)
                     /locus_tag="P0D74_RS39320"
     CDS             complement(15861..16523)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014152093.1"
                     /locus_tag="P0D74_RS39320"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_275466931.1"
                     /transl_table=11
                     /translation="MTGDLAWIGEHWYSGAIVKDGMRADISLTAVRGVDPVDFVVRLGA
                     DRRMAERPPLFKDFDRRGVDWGDSVAMFGRSGEWAYVLEMERSTWHLICLDRLGQDTLV
                     GQGEELVCLDRFLHEAPWVFYGDAAGEMSSIEPGDSLLETAIPREDRLGAFAALDAAMR
                     RAGAVRATFPGCEDPEDEDEELTRRLFGAVGEHLGLSLPRREIEQGLLPAVLLPSPL"
     misc_feature    16687..16698
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: medium, score: 18.46"
                     /tool="antismash"
     gene            17459..18586
                     /locus_tag="P0D74_RS39325"
     CDS             17459..18586
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1087: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006601995.1"
                     /locus_tag="P0D74_RS39325"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="NAD(P)/FAD-dependent oxidoreductase"
                     /protein_id="WP_275466932.1"
                     /transl_table=11
                     /translation="MSTAPRIAIVGGGLGGLVCARTLQRLGVPVTVFEREATPDSRSQG
                     GNLDIRADTGQVGLRAAGLLDEFLALSRPEGQEMRLMDRSATLLHHHRPEPGDTGAPEV
                     DRGQLRALLLDSLTPGTVRWDHSVARAVPLGDGTVRLEFTRGNVEEFDLVVGADGAWSQ
                     VRAALSEAQPAYTGCTFVEARFHDVDRRFPALAERVGQGTLWAKAGCLSLMAQRNADAH
                     IRVYIGFRGPLDWHEGIDPTDTEALRARLLGMFEGFDESLRELMSLNDGAFILRPVFVL
                     PVPHRWERVPGITLLGDAAHLMPPVGVGANLAMLDGAELARALADRPEVDAAVAAYEDV
                     MVPRSAEQAAATAALLAALMPDTDSTEPGFPDFFG"
     gene            complement(19103..19570)
                     /locus_tag="P0D74_RS39330"
     CDS             complement(19103..19570)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1135: MarR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016575896.1"
                     /locus_tag="P0D74_RS39330"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="MarR family transcriptional regulator"
                     /protein_id="WP_275466933.1"
                     /transl_table=11
                     /translation="MTATDPAMTALAHGWSALSLLHGRIEGSVERALQAAHQLSAREYA
                     LLDVLSRQHDGEGGHLQMRQVADSVVLSQSATTRLVTRLEDRGLLSRYLCPTDRRGIYT
                     DVTDDGRRLLEEARPTHNTALRKALDQAATEPVLAPLVLAVQQLPGGLRPA"
     gene            19753..20979
                     /locus_tag="P0D74_RS39335"
     CDS             19753..20979
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1184: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019525351.1"
                     /locus_tag="P0D74_RS39335"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="MFS transporter"
                     /protein_id="WP_275466934.1"
                     /transl_table=11
                     /translation="MPLALLALAIGAFGIGTTEFVIMGLLPQVGADLGVSVPAAGFLVT
                     GYALGVTIGAPIMTVLGTRISRKNMLMLLMGLFVLGNLISAVAPVFAVMLIGRVVASLA
                     HGAFFGIGSVVAAELVAPEKKAGAISMMFTGLTVANVVGVPLGTFVGQRAGWRVTFLIV
                     AALGVLGLVGVAKLVPDVPKPAGVRLRHEVAAFKDAQVILAMAMTVLGFGGVFAAITYI
                     APMMTGVGGFAESSVTWLMVVFGLGMVAGNLIGGRFADRRLMPLLYTALGGLALVLLLF
                     TFLASGKVASVVAIFLIGALGFATVPPLQKRVLDHAHGAPTLASAANIGAFNLGNALSA
                     WLGGLVISAGLGYAAPNAVGAVLAAAALALAVLSHRLERRRHRTTAAAGSVAAPDQGAA
                     PAAAGAVHS"
ORIGIN
        1 gcggtgcggg acgaccggag ggcagcgccg cggtcctgcg ctgagtcggc acttgcccga
       61 cgcccccctg cgacgggttc caacgggcgg aagccaaggt ctacgtggca gcggcccacc
      121 gcggcacggg cctggcgggc gcgctcctcg cacgggcctg gctcgcggtc gctgatcggg
      181 ctcacagatc acggcctgac agatcacggc ctcacagagc acggcctcac agactcgcga
      241 ggaggcggtc gagcgggggc ggtgtccggt ccggggcgag ggcctcgacg agcagccggc
      301 cgtagcggat cttgcggccc ttcttcgtgc cgaggaagcg ccgcgcctgc tgatgcctgg
      361 gccggccgtg ctgtgcgggc tggcgctgga aggtctgcca ggcgcgcagg tcgccctcgg
      421 cgctgaggat ctcctcgacc cccaccgtgc ccagcgcgcg gatcagttcg tcctccaggt
      481 ccgcagcgca cacgtagacg tcctgcagcg gtgcctgtgc ccgcgtcagg ccgcgttcgt
      541 agaagccccg ttcgccctcg tcgcagagtc ccgtcaggcg cagaccgagg ccgggcggcc
      601 cgaggaggcc ggcatagcgg gcgacgctca tcgccccgcc catcggcatg acgcacacgc
      661 cgtcggcagc caggtcccgg ccacgccggg cggccagcgc ctcgacggcc gcgagatcgc
      721 tcagcccttc cacgagcacc gcggtccgca cgcccagtcc ctccgccaga tcgcgcgccg
      781 gcctgtcggg accgcccgtc gcccatttgg tgaccgcatc ccggaacgcc ttcatgtccg
      841 ccatggggcg agtctgccct cccacccgtg ccacggcacg gaattattcg acgtcctcac
      901 gacgtgcggc ggtacgcgtg ctcaggtcgc cacggctcgg ctcctccggg attgccttgg
      961 cgtccgtccc ccgctcgcgg ccgtgttagc caggcgttag cggagcggcg gcctggcgat
     1021 agcgctctcg cacagagtgg gggcgtcgcg aggaatcctc gccacagact gcccccggag
     1081 gaaacacgac atgcgctcca gcaccaccgc ccgcatcgcc cgtagccgtt ctctgcgcgt
     1141 tggcgcggcg gccctgaccg cggccgccgg cctgtccctg gttgcctggt ccggctcggg
     1201 ctccgccgac gccaagcccg cgggacggac gagcgcgagt gcgtcggtcg ccgatgccag
     1261 tcccgcgggc tggtccggat tgcagagcgt cggtgccaag gcgtccctca cgggcgagca
     1321 ctcgggcggc acgcgcgcct ccacggccaa gtcggcttcc ccggtccgca cccagaccct
     1381 ggtggacggc agcacggcca ggatctacga cctcggcggc cagcgctacc gcgccgagat
     1441 cgtcagccgc ggtgcggtgt tggcgacgtt ggagacgacg gaggaggaga tcgacgccgg
     1501 gctggacgcc aacgacatgt tcgtggtgct cacgatgggc ggcgaggtcc actcctggat
     1561 gggtggtggg cagcagggcc ccggtacgtt ccacctcgcg ggtggttgga ccgccaaggt
     1621 gacgaagatc ggcgaactgc ggtaccgcgc gcagatcatc ggccacgacg gttcggtgga
     1681 cgccacgttg gagaccaagg gtcacgacgt cggcctcgac gccaacggag tctccatcgt
     1741 gctcagcgcc ggcggcgtga tcagcgccca cgagtgaacc ccgtgccgac tgcgggcggt
     1801 aaagcccacg gcggtggctc cgccgcccgc agtcagagga cgccgcccgg gacggtgccg
     1861 ggcctgccct gcatggccag cgggggcgtc ccgttccccc ggactaccgg gtcctgaagc
     1921 gccggaagag gttccgggcc acgtacaccc ccgggccgcc gaaaccgacg atgtcgacgc
     1981 gcccgtcacc ggtgatgtcg gcgaggaagc gggggtggcg gtcgacccgc cagccgccgg
     2041 agtcctcgtt gtacccgaag ccgctgcaca ccagttgggc ctgctcgaac gtgccgtcgc
     2101 cgcggctgtg cgacacccag accccctcgt cgccgaagcc gacgacgtcg gggttgccgt
     2161 cgccggtgac gtcgccgagg aaccggagat gcttcccgct cgtccatccc tgggcgggcc
     2221 cgaagtcgtt caggacgagc ttcgcgggcc cgaacgtgcc gtcgccgcgc ccgcgcgaga
     2281 cgacgacgcc ctgcgggccg aacccgacga ggtcgagcga cccgccatcg gtggtcctga
     2341 gcaggaaccg ggggtgctcc tcgaccgtgc cccacccctg gtcgaccccg aaggcgtcga
     2401 ggacgtacag ggggtcggcg aacgtccctt cctcgtcctg gagtgacacc cagacgccgt
     2461 cgtcgtggca gccgacgacg tcgagtctgc cgtctccggt ggtgtcgccg aggaagcgcg
     2521 ggtgcttgtc ggcgagccaa ccacccgcct tctcgtcgtg gccgaacgcc cggaggaccg
     2581 gctcgtcgcc gatcggcgcg aacgtccctt cctcgtcctg gagtgacacc cagacgccgt
     2641 cgtcgtggca gccgacgacg tcgagtctgc cgtctccggt ggtgtcggcg aggaagcggg
     2701 gatgcctgtc ggcgagccac ccaccggccg gctcgccgtg gccgaacgcc ttgaggaccg
     2761 gctcgcccgc gggcgcgaac gtcccgtcct cgccctgagg ggacacccgg acaccatcgg
     2821 cggcgagcac gacgacatcg ggcttgccgc ggcccgtcgt gtccacgagg gtccacaggt
     2881 cctcggggcc cgccgcgggt acgggtgggt gcaggacgcg ctcttcgtcg tcgaacgtgc
     2941 cgtcgcccct gctggacgac gtcacggcgc cttcctcggg cttgagcccc acgacgtccg
     3001 cccgccccgc tcccgtggtg tcggcgagga accgcgcacc ggccccggcc caccagcccg
     3061 gttgtccgcc gggcgcgcgg gtgccccctt cgctcttcca ctgcccggcg tcctcgtcgc
     3121 tcccgaactg ctccaggacc agcagcatgt tgctgaagga gggcgtcgcg ccgggggccg
     3181 gccgcagcgc ggtcgagggg gccagccgcc aggattggcg gccgttccag tgccccagtg
     3241 ccgcccagcg caacgcgggg tcactggtgc gctcgggctc ggccggcacg aaccgccacc
     3301 gctggctctc cgcgccgtcg tcgtgctcgc gcagcacgac ccgggtgtcg tccgcgccgg
     3361 gctcgtcgag gtcgaggacg gcgccgtcgg tcgcgccctc gatgaagtag aggcccgctt
     3421 cgccctcaac ggggacgacg tgccactgct gacgctgatt gccgtcggcg gcgtcccact
     3481 ggcggacggc gcggtccgcg gcagccgggt cgtcgagcac cttgccggtg accgcgttgc
     3541 ggatcacata tccctggttg tcctctgttt cctcgccttc cgcggcctgc acgggggcga
     3601 gctgccactg ctccgggctc gggccgtcat cggggaagtc gcggacgacg agcgccccgt
     3661 ccgcggtcgg cgcggcctcg gcgccgaggg gcttccccgt ggccgcgttg acgatctcca
     3721 gcttcagttc ttccgtgggc acggacatcg tggtgcctct tccaggcggt tcgggcgttg
     3781 gctcgggacg gttctggcac ggcgacggcc gcggatcacg tgaagacgtg gtggtacggg
     3841 acgttccact cgttgggcag ccgcggatag aacgtgttga tgaccgtccc ggtgaagtcc
     3901 ccgccccagt tgtaggtgag gcgtacctcg ctgtcggccg tcaccgcgtg gtccttgaac
     3961 ccgaggatgg cgtcggggtg ggtgatcggt acgaaggtga tcccgcccca cggcgtcacc
     4021 gtgacgaccc agagctgggt gtcctcgggc gcgccgttcc tcccgcgcca cttgtcgccg
     4081 accttgtcgg ggagcccgac ctgaacggtg tcggccgtgc tcttcggtgc ttcctggtgg
     4141 acggtgatgc gcctgcgccg cggcttcggg gcgccgtcgt cgccgcgccc ggcgtcggct
     4201 tcgcccgcac cggcgggttt gggcgacacc tgccccgcgg cgctctcgat gacgtacagc
     4261 ggtcgctgcc cgaagaagcc ggcaggggtg atgtaccaga ggtggccctg cgcttccttg
     4321 gtgtccgggt cgagcgcggt ggccagcttg acccccttgt cgtggctctc ctccttcagc
     4381 tcggcgggcc gcaggtagcc gccgttgaag gcgtggacga gcatgaccgg ccggttttcg
     4441 agcagtgccg ccacgattgc gttgtcgtag ctgttcaccg ccaccggtcc gccgaccacc
     4501 aaattcgaca tcgccgtgcg ttcttgggtg tacatcgcga aaacctcacc tgttctgaat
     4561 gtggagaaca acgcgtcggg cggtcagttc agtgctttat cgcgcggaat tactggagct
     4621 tcaatcgcct tcggcgaaga cgacttcgaa agcgatgaga tggccggatc caataccgtc
     4681 acccacgtca acggccgggg ccgcggtgct cgcaggcagg accgtcggag agtcatcgtc
     4741 gggtgattgg cggcgcctca acgtaccgtc agttcttgcg agttgagaac ggtcgccgaa
     4801 ccttgatcac ccgattgggt gaatgcctgg agtcaccgtt tgggtgatgg aggtcgcggt
     4861 aatttcgttg gtcgggacat acacggatgc ctgataccgc tttaccgttc accgaacgca
     4921 gtgcgaccag accagtcgag gacggggaat gccttccaac gcgtacaacc tggaacgggc
     4981 caagcgccag ccactgacga agaagaacct gcgagaactc aacatcgagc agacctggcg
     5041 gtccatcctg gaccacccca acctggtcta cgtcgacgac tacggcgtgc gtcacaagcc
     5101 cgtcgggttc tccttgaaca agtcgagctt cggcgccttc cccgggtccg cgttcaaact
     5161 gggctggctc gcctacatga acctcgggga gccgctgatc gaggagcggc gcaacatcag
     5221 ccagccgccg cccgacacgt tctcctcgcg cgcctacgtc aaccgcagtc agacgtccaa
     5281 catgacgttc aacgactcgg tcgagttcac cgtgtcgaac gaggtcacgt ggtcgctcca
     5341 gggggaggcc cagctcacct tcggcggcag cgtcggcgcg gagctccagc tgcagttgca
     5401 gagccagctc caggtggacc tccaggcgca gttcgggacg gagctgcaga accagctcca
     5461 gaacgagatg gcgaacagcg tggagaacac cgtgaccaac gagaacagca aggacgacat
     5521 cggggtcgac accgccaacg gcaccaccaa cggcgtgacg aactcgatga cgaacggcgt
     5581 gacgaactcc gcgtcgaact cggtgacgac ttccggggcg ttcacgacca cgggcagcgc
     5641 caccggcagc gcggagctca acgcccagtt gatgctgggc atcaccggct ccgtcggcgg
     5701 ttccctgacc accagttggg cctcgaactc gcagatctcc ggcgaggtcc cgccgggctc
     5761 ccgcgtggac accatcgtca cgcagcggcg cgtccgcaag cagtactcct acgagatccc
     5821 ggtgaccttc tccgggttgc tcgcggtgaa gtacgacgta ccggtggcgg ttctgtctcc
     5881 cccgcagtcc aggaaccacc cgggccttga gtacgtggtc gcccgcgacc tcggtgacgt
     5941 cgacctggcg ggcggcaacg gcttccgcat gaaagggctg gccgaggtcg tgtccgccct
     6001 ggaggtccac cacacgatgt tcgacggcga gagcctgacc ggcagcgaac gagagctgca
     6061 caagcaacct tgaccagcga gtggcaccgc caccacgacg accaggagtg acgaccatgg
     6121 tgttcggcaa catcttcggc ttcgcggaca aaggcgcggg gctcttctcg gtgaccaccg
     6181 acggcaccaa gccgcagccg ggggcgggcg tcgacttcga ggacgccgac gacgacacgt
     6241 acgacgacac gagcgcgagc ctgttcaaca acgcgatcca cggggccaac tcccgcgcga
     6301 aggtcgtgca ggagacctcg cccgaagctc gggccatcct gggcttcctc ggttccttcg
     6361 tccagaccac ccaggcgtcg gccggcgcgc aggcccagta cgcccagaac cccggttcgg
     6421 tctccaatgc ggcgtcggcc ggcatgaagg agtcgagctc cacggtgacg gagcacggcg
     6481 acctccagaa ggacgaggac ctgcagagca agccgaagaa gagcgatttc aaccaggccc
     6541 ccaaggcacc cccggccccc gaggcccaga cccccaaggc gtccaagccg accgccgagg
     6601 acccgtccgc ctccaacgac aaccgctcgt agcaggcggt cagtgaacgc tgaagggatg
     6661 acgatgagca ctgcccacga ggcaaccacg ggtggcgagg actccgcccc tccgatcagc
     6721 acggtcgcgg ggaccggggt cagcggcttc gcaggggaca acgggcctgc tgtatcagct
     6781 cagttgaaca acccgtacgg ggtcgtggtg gactccaccg gcaccctcta cgtctccgag
     6841 tacaacaacc accgggtccg gaagatcacg actgacggga agatcagcac cgtcgtcggc
     6901 acggacacca agggcttcag cggtgactgc ggccccgccg cctcggccca actgaaccgc
     6961 ccccgggggg tggcggtgga cagcgcgggc accgtctaca tcgccgattc cgacaaccac
     7021 cgggtccgga aggtcgcggc cgacggaaag gtctgcaccg tcgccggcac cggcaccaag
     7081 ggcttcagtg gtgacggcgg ccccgccacc gccgcccagt tggacggccc gtacggggtg
     7141 gcggtggaca gcaccggcac cctctacgtc accgagcaca acaaccgccg agttcggaag
     7201 atcacgacgg acgggctgat cagcacggtc gcggggaccg ggaccaaggg ctccgacgga
     7261 gacggtggtc cggcgctctc ggcccggctg accaacccgc gcggagtggc ggtgggccgt
     7321 gcgggcgagc tctacatcgt cgataccggc agccaccggg tccggcaggt cacggccgac
     7381 gggctgatca gcgcggtcgc gggcaccggg accaagggct tcagtggtga cggcggcccc
     7441 gccaccgccg cccagttgga caacccgttc gaggtgacgg tggacagtat cggcaccctc
     7501 tacatcgccg atttcggcaa caaccgggtc cggcaggtca cgtccgacgg gaagatcagc
     7561 acggtcgccg gcaccggcac cgggggctcc gacggtgatg acggcccggc cgcgtcggcc
     7621 cagctgaaca aaccgatcgg gctcgcagtg gaccgcgcca acaccctcta catcgccgac
     7681 cacgccaacc accgggttcg aaaggtcgtg ttggcgaaga gggccgggct gcccgcatcg
     7741 ggcacggtgg tctcctgggc caacgtccgc agcaggctgc ggatggcggt ccagcgcgag
     7801 tccaccaagg acggggccga gatccaccag accctcgcca cccccagggg ccaccagcgg
     7861 tggcggctgg tcgtcgcggg ccaggtcgac ggcgagaacc tgtacacgat cgagaacctg
     7921 cgcagcggca aggtcctgga gatcgtcggg gcgcacgaga cggccggagc agtggtcgcg
     7981 caacgggcct acgagggtga cgacgcccac caccagcaat ggaggctgat cccggtgagc
     8041 tccgcgaccg acaccccgca ggtgtacgag atcgcgaacc ggaacagcgg tctgctcctg
     8101 cgcgtcgaca ccaacgcccg cacggcgatc cagcagcacc gggcggaggg cgaccaccgg
     8161 gaccggcagt ggcacctgct ccccgtgtga cacacgtgtg gtcaggggcg acctcgcccc
     8221 tgaccacacg ggagccgacc ccgccaacgc ccctacgtga acgacccggc cgcggcggca
     8281 actccgacca gagcggcagg cgcggggagt tggcgacggg ggtgacgggg gcgacggcta
     8341 ctgcgcgcct tcaggcggtg ggtggcgttc ggtaggtgtg gtggaggtgg ttgaggtagt
     8401 gctcggcgct ggggtggggg tggtcctggg cgccgtggcg gtggagttcg gtccgtgcgt
     8461 cggggtggac acggatggtg gtggtcgcgc gcctggggga tgcggcgagt ggggtggggg
     8521 cggtgaggac gggagtgcgg ggggcgaagt gcggcgcggc ctcggcaggg gtggctgcgg
     8581 gcgggtggcc ggtgcggttg gcgctgctga cgtagagcag ggggaagtcg tccaggagcg
     8641 gtgccagggg ctgccagcgg gcggcgaaca ggagcgtcca gccgtccctg gcggcggggg
     8701 ccagccagga cgggacaccg tgcgggcggc gcaggggcgc caggagggtg acgagttcct
     8761 cggtgagcag gcggcgggcg agccggtgtg cgtcggggcc gaggtcgagg tgctcggtca
     8821 gttcctcgcg tgtgtgcggg tggtgggccc atagggcgac ggcctggtcg gcggggcgtc
     8881 ccttggcgac gttgacggcg gcgggccggg tggcggtgac gacgcaggtg agcggggcgg
     8941 gattgggcag gacgactgcc cggccttggg cgagagcgtg gtggacggtg gcggtgtcgc
     9001 tggtggccgg ggtggcgtcg actgcgggtc ggtggctcat gcggtggtct ccgtgcggtg
     9061 ctcggtgagg ccgtcgaggt aggcggcgaa ggcgtgttcg ccgacgacgg cgcggccggc
     9121 tcacgcacga catcccgcac gcctggcccc actctcgcag tgacccagta ggggtactca
     9181 ccgtgccggt gaactcgcga agcgtgatgt cggcccccga aagggctttc agcggagggt
     9241 agttgcgcct acccggcgac ccctgctatg ggcgaggcgg gtcccctgcg ggatgcctgg
     9301 ccttgccggc agcctgccgc gcccggccct gactcggctg gcacgccggc cggcaacggc
     9361 gaggcgtgtg cagggtgttg ctggtcctcc ccgtcacacc ggatcggggg gatgacgaac
     9421 cgggtccggc acgttcacgt gccggacccg acagcgtcag ccattcatgg ccgcccagaa
     9481 ctcctcgaac gacatctggc ggtcgccgtc ggtgtcgagg gagtcgatca gctcctgagc
     9541 ctgcgcctcg gtgatctccg tgccctccag ctccgcgatg acctggcggt actcctccgc
     9601 ggtgacctga ccgtccccgt cgaggtcgta gcgcgcgaaa accttgcgtg ccgccgtctc
     9661 cacgatgtct gccatgtgct tcgcccttcc gtgatccttc actgacgggc ccaggttatc
     9721 cgtcctcccg gacgcctcgt gggtgcgccc caacgtgcct ggccgccgcg ggcccggccc
     9781 acgccgaacc ggtggcttcc gccaccgcgc caggcgagtc gtcgacgccg gacggcgagg
     9841 tactgctcgg ggaacaaggc ccccgacccc tacggcctgc cggctcaccc gcgaccgtcc
     9901 gttggaagcg gtcacttcgc accacgcacc gatggtgttg aatgccggtt ggcggtgtcc
     9961 gtcgacggcc gtcgcgcttg acggggtgcc agggagaacg atgagtgctg agatcgaggc
    10021 cggtgtgcac gagcggctcg ccggataccg ggaccgcttc cacgggttgt tcgcggacta
    10081 cttcgactcg gtcgccaggc aggggccgcc gcgcaacgcg ttcgtgcccg aggccctgga
    10141 gctggtgcgg gacatgtcgc tgcggggcgg caagcggcta cgggtcgcgt tggtgtacga
    10201 ggctgcgcga ctggtgaccc ccgatgccgt gacgggcttg gacgaggccg cgctcagcat
    10261 cgagttgttg cagacgcacg ggctgatcca cgacgacatc atcgacgact ccccggtgcg
    10321 ccggggagcg ccgtcggtgt actacgccta ccgcgaccgg ttccccgacc gtccgcacac
    10381 ggcattgggc ctggccgtcc tggccgggga cctggccgcg ttcctgtcgg tccaggtgtt
    10441 gctgaccgcg ccggtgcccc gcgacctgcg gcaggcgatg gccgcggtcc aggcgacggc
    10501 gggggcggac acggtccgcg gccaattcct cgacctggag cgcgacttcg gcccggtgcc
    10561 cgaccgcgcg gcgctggaca ccgtgtccga gtacaagagc gcccgctact cggtgctggc
    10621 tccgttgcag ctgggcctgc tcgcggccgg cgcggacgtg accgcccacg aggaggaact
    10681 gacccggtac gcccgactgc tcggcgtgag cgggcagatg cgcgacgact acctcgacct
    10741 gttcgcggac gcaggcacgg tcggcaagcc ggccggatcg gacctgcgcg agggccgccg
    10801 cagctacgcg gtgtgcgcac tgctggcagc cacgagcggc gcggagcggg cggtggtgga
    10861 gtcggcgctc gccggccccg gctgcccgcc gcagaccgtc gaacgggttc aggacatcgc
    10921 caggcaccac ggcgtcgacg agcaacttct cgccgagatc cgcggcggtg ccgaggaggc
    10981 ggccgccgtc gccgccacct ggcgggggcg gtggcgggac gaagccgtcg cgttcttcga
    11041 gcaactgccg ctgtggggcg cactacgcac ccagtgacca tgcgcggcct tcggggacgg
    11101 cgtgcgcaga caccctcccg ttgcggaccg tcgtgactgc cacgccgatg gcgaggacgg
    11161 ccaacacggc gacgacgacc gccggggccg gcacaggcgc acgccctgcc tgtggcagcg
    11221 ccgcagcggt cagccggatg cggcggacat caggacctcg accaaccggt ccgccgcgtc
    11281 cggccgcccg tgcgcccggg cccgctccgc catcgtcgcc cgcagtgcgg ggtcggtgag
    11341 cagcgggccc acggcgtcct tcaggcggcc ggcggtgacg tcgccgagca aggcgagcgc
    11401 cgcccccgac gcctccaagt gttgtgcgtt gtgcgcctgt tcattgcccg ccgcggaggc
    11461 cagcggcacg aacacggccg gcttgccgag cgcggtgagc tcggcgaggg tcccggcacc
    11521 gctccgcgac acgacgacgt ccgcgagcgc caggacgtcg ggcagttccg ggcccacgaa
    11581 accggtcagg tggtagcggc cggccaacgc ggtcggcagc gctgccgcat ggcggcgtag
    11641 ttccgccacg ttgtccgggc cgcactggtg gacgacgttg gcctgctgga gcagccacgg
    11701 cagggcgtcc cgcacgacgt cgttgatctg ccgggcccct tgcgcgcccc cggtgacgta
    11761 caccgtcggc agcccccggt cgaacgcgtg cagtcccaga ctctgcaccg ccttgtccgg
    11821 ctgcccggca agcacctcgg ggcggatggg atttcccgtg acgaccgccc gcccgcgcac
    11881 ccgctccggc agcagcggca ccgaggactc cgacgacacc gcgatccgcg tcgccgagcc
    11941 ggcgagcttg cggttggcca ggcccagccg cacggtctgt tcgtgcagca ccagcggacg
    12001 ccggcagatg cgcgccgcca ggcccgtcgg cacggcgacg tagccgccgg tggcgagcac
    12061 cacgtccggc ccgaagcccg cgaccagctt ccgcgcctgc gcgacgccga gcggcacccg
    12121 cgccatgtcc ttgatgttgg ccgccgacat catcttgagc gggttcttcg cccggcgaac
    12181 cttgccggtg gccaccgtgg cgaacgggat cccctcggcc ggggcgaccc gggcctccag
    12241 gccgtcggca gtgccgatcc acaacacgtc gagggccctg ccctcggccg acagccgccg
    12301 gcgcagcgca cggatcgcgg tgagcgccgg atacgtgtga ccaccggtgc cgccacccgt
    12361 gacgacaaga cgaaaggcat cgacgttgct cactggagct accccaaatc tggcgacggt
    12421 cggacggaag cgccacagta gccgctcgcc gcaggcgtcc cggtcgcgcg caacggggaa
    12481 tcggcgggca ggttcgctcg ggtgcgcaaa cacagtgcag gcccggtggg atccaccggg
    12541 cctgcaccgt ttcagtagcg gggacaggat ttgaacctgc gacctctggg ttatgagccc
    12601 agcgagctac cgagctgctc caccccgcga cgacaccgtg aactgtacgg cactgacgcg
    12661 gatcgaccga atcgatgtcg ggtggctgtg gccgcaggct cgccacggtc gcccgtcagc
    12721 tcgctaccag gccgttcgac ggccgccatg gagcggccgt cgactgctgg acatcgctcg
    12781 gtcggaagcc ccggacggac gggcctactc ggtgtggtcg gtgtggtcgg tgcggtcggt
    12841 caaggcagga tctcgacgta gccgtcggtt ccgtgcacgc ggatccgctg cccgtcgcgg
    12901 atcagccggg tggcctgtgc cacgcccacg acggccggca ggccgtactc ccgggcgatc
    12961 accgcgccat gggtcatcag tccgcccacc tccgtcacca ggcccgcgat gccgacgaac
    13021 agcggcgacc agctcggatc cgtgaaggtc gtgaccagga tgtcgcccgc ttcgagatcg
    13081 gcctccgcca tgtcgaggac gacgcgggcc ctgccctcga cggtcccgac ggacaccggt
    13141 aggccgacca gggcaccggc cggcacgtcg tcgcgccggt acgccccggt gacggcctcg
    13201 ccgtccgagg tgagcacccg gggcggcgtg agcgcctggt acgcgcggaa cgcgtccttg
    13261 cgctgctgga cgagccggcc gtccacctgg tgtgagcgca cgacgtcgtg gagctcctgg
    13321 aacgtgaggt agaagacgtc ctcctgcgcg gggagtacgt cggccgccac gaggcgctgg
    13381 gcctccgcca gcagggcctg cttgtacacg aagtagcggc tgacgatgcc gtacttcggg
    13441 tactcccggt acccgatgaa ggtccgcacc cggtcgatca tccgcttggt ctcgtcggcc
    13501 ttccggtccc cgtccggcag cgcccgcaag cgcgccagca cgtcctcctc cttctcctgc
    13561 gccttccgcc gcccctcctc gaagcgtcgc gcggcggcgc ccggcgcgaa gttccggacg
    13621 ttgtccagga gcacgggcac gagcgtggtg ggacgctcgc gccaccgcgg ccgcgtgatg
    13681 tcgatctcgc cgacgcagcg catgccgtac cggtcgaggt agccctcgat ggcgtcgcgc
    13741 gcttcggccc cgcccgcgac cttcgccagc tcgcccagga agtcctcgtc ctcgacgtcc
    13801 tgtaggaagg ccaccacctc cggtcgcgcg cggatcacgt ccgcgacgtc cagcagcgcc
    13861 agtcccatct cggaggtgat gttgtcgggg gcggacagcg tgagcgtgtc ggccgcgttc
    13921 ttctcgccca gccactcctg gagtttgtcg ttgagccacc aggtggcgtc catccccgcc
    13981 atgatcgcct ggacgctcag cggatcaccg aggacccgct tgtgctcgtc gaaggcttcc
    14041 agcaggaagt cgaacagctc cggtccggtc ctcgtccgga tgttgcgttc cagggcggcg
    14101 acggacgccc ggctgcgctc gatcagctcc ttgacgacgg ccggatcgtt gtcgatgggg
    14161 gcgggcgcac cgccggccgt cggcctgccg ggcaccgcgt ccggcagcga cgggacgaag
    14221 tcgtcgcggt cgaggacggt ctccaacgcg tccctgacca gcggatcgcc cttccccatg
    14281 acgtccagga gggcggcgcg gcccgcgggc gaggacaggc gccgggtggc gtcgacgaac
    14341 agcctcccgc cggccgcgtg catcggcacc atggccgtca gctgccacat ggaaagcccc
    14401 agcggcttca tggcgtcggt catcatctgc tggtgaccga cggagacgta gacgtggttc
    14461 tcctcgtcgc cggcctcggg aacggggaac aacgtcgtga tcggccggct ctgcacgatc
    14521 cggaagccgt cgtcgaccag acaccattcg atgtcctgcg gacggccgaa gtgcgcctcg
    14581 atccgccgcc cgagctccac caggcgcacg acctgcgcat ccgtgagcgc cggctgctcc
    14641 tgttgctgcg cgtcgatcgc cacctcctgc gtaccgccgg ccggcagggc ctgtacggca
    14701 cgctgcttgg cggcgatcgt cttggcgacg acctcgccgt cccggacggt gaagacgtcg
    14761 gggttcacca gcccggagac cagggcctcg ccgaggccga agccggcgtc cacggtggcg
    14821 accttccggt tgcccgagac ggggtcggcc gtgaacagga cgccggacgc gtgcgggaag
    14881 gccatccgct gcacgaccac ggccatccgg accgtgcggt ggtcgatgcc gttccgctgg
    14941 cggtaggtca cggcccgctc ggtgaagagc gaggcccagc accggctgac gtgccggagg
    15001 atctccgtcc gccccatgac gttcaggtac gtgtcctgct ggccggcgaa ggaggccgtc
    15061 ggcaggtcct ccgccgtcgc gctggaccgg accgcgtagg cggcctgctc gccgagccgg
    15121 ccgagcgcgc gggtgatcgc cgccgcgaga tcgtccggga cggcgattcc ttcgatcgtc
    15181 cgacgcacct gcgcgctgag cctgcggacc gcctcccggt cgtccgggtc cagacgcgac
    15241 aactgatcga gctgatcgtc gatcgacggc gcttccgcca tcacccgccg gaaggcgtcc
    15301 gtcgtcacgc aaaagccctc cggcacccgg acgccgtcga tccgggacag tccgcccagg
    15361 tgcgcgccct tgccgccgac gaccgccccc tgcatctcgt cggcgtcgcg aagatcccac
    15421 acataccgct cgatcactgc gacacctccg agacagccac gttccctcgc actgcggtgg
    15481 ccgatcgcat caccgccgcc tccagtggtc cgacggcacc gcgtccccca tacgtcgaca
    15541 acaactcacg cacgtagtgc cccattttcc ctaggcgctg gcatcggtcg acgattgtgc
    15601 gccatacccg gggccttgcg gcaagccccc cagtacgcta taagttgaga gtggcaagga
    15661 gagtgttctc cttgcctttg ctgttttccc gtcccgggga accgacagac tccgaacgtg
    15721 tcctggttgg gcagcgggcc gaaccgaaac ccttcggcga acttctctac gggatggggg
    15781 agttggtttc ggagagttcg ggtgcgggtg cgggcggccc tcccggtagc caggccgccg
    15841 gcgtcccgct gccggtccgt tcagagtggc gagggcagga gcacagcggg cagtagcccc
    15901 tgctcgatct cccgacgcgg cagcgagagc ccgagatgct cgccgaccgc cccgaacagc
    15961 cgtctcgtca gctcctcgtc ctcgtcctcg gggtcctcgc agccggggaa ggtggctcgc
    16021 accgcgccgg cccggcgcat ggccgcatcc agtgcggcga acgccccgag ccggtcctcg
    16081 cgcgggatcg cggtctccag caggctgtca ccgggctcga tggaactcat ttcgccggct
    16141 gcgtcgccgt agaacaccca cggggcctcg tgcaggaagc gatccaggca gacgagttcc
    16201 tcgccctgcc ccaccagggt gtcctggccc agccggtcaa ggcagatgag gtgccaggtg
    16261 gatcgctcca tctccaggac gtacgcccac tcgccgctac ggccgaacat cgccacgctg
    16321 tcgccccagt ccacgccccg cctgtcgaag tccttgaaca ggggaggtcg ttcggccatg
    16381 cggcggtcgg caccgaggcg gaccacgaag tccaccggat ccacgccccg taccgccgtg
    16441 agggagatgt ccgcccgcat cccgtccttg acgatcgcac cgctgtacca gtgctccccg
    16501 atccacgcca agtcgcccgt catcgtgccg acccctctcc ccgatcttcc gttgcgtcat
    16561 cgtggtgcag tcgcgccccg cggcgccagc tcgactgctc agtcccgcca gctgggagcc
    16621 agggcacaca ggagtgcgtc ccggtggcgc gggccgtacg gctgtccatg gtcgctcagg
    16681 cagtcggaac gtgaacgcga tcagcggggg tctccaacgc gacggctcgt cggggtggcg
    16741 cggagcggtg actgggatgc ggcgttggaa ccgggtggtt ggcggggcgc ggactgtcgg
    16801 gcggggggca cgctcaccgg actccgggcg gcggtgcgaa tatcagtggc tccggcacac
    16861 ctcccgcact aacctcacca ggcatgaacc agcggcagcg caccatgccc tcccgggatt
    16921 gccggcacct gctcgaagcg actgcgggcg gtgacacggc ccgcccggtg gggctgctgc
    16981 gggcagaagt cgcctgagag cggggcgacc gagaggtcga ttccccgctc gggacggcat
    17041 ccgcccggcg gggaatgccg gcgcgccggc tcgtggctgc gcattgcggc tgaccactgc
    17101 gaagtcgggg cgtggcgctt gttcttgaag gcgtggattc ccggggcgcc gcgggcccgg
    17161 ttccggccgg gccgacggtc gtgcgccgcc acgcactgag ggcgcggacg aacggtgcac
    17221 gcatcgttgt cgcacggctc gctcccgatc ctcgtgaggt acgcggcgtc ggtcgctctc
    17281 ctccagggtt gctgccctct cgacgggttg tattccctcg ggcggtaggg gagttcttgc
    17341 cctccgagtc accagtcctg tcataagagc ctctggatcc ctgcgagttg gtcttctttc
    17401 gctgccgacc atcgccccgt acccgtttac gcattccttc tccgatcgga gcaccaccat
    17461 gtccaccgcc cctcgtatcg cgatagtcgg agggggcctc ggcggtctcg tctgtgcccg
    17521 tacccttcag cggctcggcg ttcccgtcac cgtcttcgag cgcgaggcga cgcctgactc
    17581 ccgttcgcag ggaggcaacc tcgacattcg tgcggacacc ggccaggtgg gcctgcgtgc
    17641 cgcggggctc ctcgacgagt tcctcgcgct ctcccggccc gaaggtcagg aaatgcgcct
    17701 catggaccgg tcggcgaccc tgttgcacca ccatcggccc gaacccggcg acaccggtgc
    17761 cccggaggtc gaccgggggc agttgcgcgc ccttttgctc gactccctca ccccgggcac
    17821 cgtgcgttgg gaccactcgg tcgcgagggc cgtcccgttg ggtgacggga cggtgcgcct
    17881 ggaattcacc cgtggcaacg tcgaggagtt cgacctggtc gtgggcgcgg acggtgcctg
    17941 gtcccaggtg cgcgcggcgc tctccgaggc ccaacccgcc tacaccggct gcacgttcgt
    18001 cgaagcccgc ttccacgacg tcgaccgcag gttccccgcg ctcgccgagc gggttggtca
    18061 gggcaccctg tgggccaagg ccggctgcct gagtctgatg gcccagcgca atgcggacgc
    18121 ccacatccgc gtctacatcg gcttccgcgg cccgctcgac tggcacgagg gcatcgaccc
    18181 gaccgacacc gaggcgctgc gtgcccgttt gctgggcatg ttcgagggtt tcgacgagag
    18241 cctgcgcgaa ctgatgagtc tgaacgacgg cgcgttcatc ctccggcccg tgttcgtcct
    18301 tccggttccg caccgttggg agcgcgttcc gggcatcacc ctgctcgggg acgccgccca
    18361 cctgatgccg ccggtcggcg tcggcgcgaa cctcgccatg ctcgatggtg ccgaactcgc
    18421 ccgggccctc gccgaccggc ccgaggtcga tgccgcggtc gccgcgtacg aggacgtcat
    18481 ggtgccccgg tccgccgagc aggccgccgc caccgcggcg cttctcgcgg ccctgatgcc
    18541 cgacaccgac tcgaccgagc cgggcttccc ggacttcttc ggctaggacg tgtccggtcg
    18601 atgacgccgg gccgatcggt gacgttcagc cgttgcctgg atccgtgctg cgactgccat
    18661 gccgggcgag tagagtccgc ctgttcacag gggagggatg ggaatttgat gaagatcaac
    18721 ggggcggtcc gggcggccgt cgcggttggt ctcataggag ccttcgcggg gtgtgcgccg
    18781 ggcaagtccg gggcggggga cgccgggacg accgcgcagg tgacaggggg tgcccacccg
    18841 gcagcgcgga ccgggacgaa tcgctaacgg tcggccgagc cgatcatgcg cgtgctcgct
    18901 gcccgcgtcg ttgacgcgga cgggggctgg gtgacctccg agtcccgaag acgaggcgcc
    18961 tgccgggcct cgcacgaagc ccggcaggat cgcggtcgcg gtcgacaagt cccacggccg
    19021 cgggcctggg acaagtcccg ggcccgcaga acgccaagtg ccgctcgtgg caagctcgtt
    19081 gtgggttgcg agcggtggtg ggtcacgccg ggcggaggcc gcccggtagt tgttggacgg
    19141 cgaggaccag gggcgcgagg acgggctcgg tggctgcctg gtcgagggcc ttgcgcaggg
    19201 cggtgttgtg ggtggggcgg gcctcttcca gtaggcgccg gccgtcgtcg gtgacgtcgg
    19261 tgtagatgcc gcggcggtcg gtggggcaca ggtagcgcga gagcagtccg cggtcttcca
    19321 gtcgggtgac cagtcgggtg gtcgcgctct gactgaggac gacggagtcg gcgacctggc
    19381 gcatctggag gtggccgccc tcgccgtcgt gctggcggct cagcacgtcg agcagcgcgt
    19441 actcgcgcgc gctgagctgg tgtgcggcct gtagtgcgcg ttcgacgctg ccttcgatgc
    19501 gtccgtgcag cagcgagagt gccgaccagc cgtgcgccag tgcggtcatc gccgggtcgg
    19561 tggcggtcat gggcggctcc ctcggtcggg tcgtgcggtc gggtcgcgca ggcggtggcg
    19621 ccggaggggg cctaccgcgg tatcacgttc atcactatac ccgcgtttgc cgttagtcag
    19681 cgtctgcaac tattgttgag gcgcgtaagg cgcttgcgca tctttccctc tcgcgtgtca
    19741 aaggacctcg tcatgccgct cgcactgctg gccctggcca taggggcctt cggaatcggc
    19801 accacggaat tcgtgatcat ggggctgttg ccccaggtcg gagcggacct cggcgtgtcc
    19861 gtgccggccg ccggcttcct ggtcaccggc tacgccctcg gcgtcacgat cggcgcaccg
    19921 atcatgaccg tcctcggcac caggatctcc cgcaagaaca tgctcatgct gttgatgggc
    19981 ctgttcgtcc tcggcaacct catctccgcc gtcgccccgg tcttcgccgt catgctgatc
    20041 ggtcgggtcg tggcctcgct ggcgcacggc gcgttcttcg gcatcggctc tgtcgtcgcc
    20101 gccgaactgg tggcgccgga gaagaaggcc ggcgcgatct ccatgatgtt caccggactg
    20161 acggtggcga acgtcgtcgg cgtgcccctg ggcaccttcg tgggtcagcg cgccggctgg
    20221 cgggtgacct tcctgatcgt cgccgccctc ggcgtgctcg gcctggtcgg cgtcgccaag
    20281 ctcgtccccg acgtgcccaa gccggcgggg gtccgactgc ggcacgaggt cgccgccttc
    20341 aaggacgccc aggtcatctt ggcgatggct atgacggtcc tcggcttcgg cggcgtgttc
    20401 gccgcgatca cctacatcgc gccgatgatg accggggtcg gcggcttcgc ggaatcctcc
    20461 gtcacctggc tgatggtggt cttcggactg ggcatggtgg ccggcaacct catcggcggc
    20521 cgcttcgcgg accgcaggct catgcccctg ctctacaccg ccctgggcgg gctggcgctg
    20581 gttctgctgc tgttcacctt cctggcctcc ggcaaggtcg cctccgtcgt ggcgatcttc
    20641 ctcatcggcg ccctcggctt cgccaccgtc ccgccgctgc agaagcgcgt cctggaccac
    20701 gcccacggcg ccccgacgct cgcctccgcg gccaacatcg gcgccttcaa cctgggcaac
    20761 gccctgtccg cctggctcgg cggcctggtg atctcggccg gcctcggcta cgcggcgccc
    20821 aacgccgtcg gcgccgtcct ggccgccgcc gcgctggcgc tcgccgtcct ctcccaccga
    20881 ctcgaacggc gccgccaccg caccaccgcg gccgccggct ccgtcgccgc ccccgaccag
    20941 ggcgccgctc ccgccgcggc gggagccgtc cactcctgaa ccctcgtacc cgcacggcac
    21001 cgcacccgtg cccgcaccga tccaaggaag ttccccatga gcaccaccac cgtcgccccg
    21061 ctgaccgcca ccgacgc
//
