LOCUS       NZ_CP119144            25433 bp    DNA     linear   CON 22-NOV-2023
DEFINITION  Streptomyces noursei strain C27 chromosome, complete genome.
ACCESSION   NZ_CP119144
VERSION     NZ_CP119144.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces noursei
  ORGANISM  Streptomyces noursei
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 9627936)
  AUTHORS   Go,B. and Lu,Y.
  TITLE     Control effect and mechanism of Streptomyces NK27 against gray mold
            of grape
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 9627936)
  AUTHORS   Go,B. and Lu,Y.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-FEB-2023) State Key Laboratory for Biology of Plant
            Diseases and Insect Pests, Institute of Plant Protection, Chinese
            Academy of Agricultural Sciences, Yuanmingyuan, Beijing 100193,
            China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 01-OCT-2021
            Assembly Method                   :: ABySS v. 2.3
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 98x
            Sequencing Technology             :: Complete Genomics
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 11/22/2023 14:00:30
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,442
            CDSs (total)                      :: 8,348
            Genes (coding)                    :: 8,203
            CDSs (with protein)               :: 8,203
            Genes (RNA)                       :: 94
            rRNAs                             :: 7, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 145
            CDSs (without protein)            :: 145
            Pseudo Genes (ambiguous residues) :: 0 of 145
            Pseudo Genes (frameshifted)       :: 46 of 145
            Pseudo Genes (incomplete)         :: 121 of 145
            Pseudo Genes (internal stop)      :: 12 of 145
            Pseudo Genes (multiple problems)  :: 30 of 145
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 16:17:19
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 8713219
            Orig. end                         :: 8738652
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP119144.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..25433
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="35"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..25433
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..25433
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:15433](+)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..15433
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     gene            complement(486..1163)
                     /locus_tag="P0D74_RS37915"
     CDS             complement(486..1163)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014151544.1"
                     /locus_tag="P0D74_RS37915"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="response regulator transcription factor"
                     /protein_id="WP_275466697.1"
                     /transl_table=11
                     /translation="MRLLIVEDEKRLATTLAKGLAAEGFAVDVAHDGREGLHLATTQGY
                     DLLILDIMLPGMNGYRVCAALRAAGDETPILMLTAKDGEYDEAEGLDTGADDYLTKPFS
                     YVVLLARVRALLRRRTRGGSPVLRLGDLVLDPNGHRCARGEEEIPLTAKEFAVLEYLAS
                     RSGHVVSKAEILEHVWDFAYDGDPNIIEVYISALRRKIDAPFGRRSITTVRGAGYRLAA
                     DRG"
     gene            complement(1340..2521)
                     /locus_tag="P0D74_RS37920"
     CDS             complement(1340..2521)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016573307.1"
                     /locus_tag="P0D74_RS37920"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="permease"
                     /protein_id="WP_275466698.1"
                     /transl_table=11
                     /translation="MSAVLHALSLTGSMTWEITWALILGFGLSAVVQAVVRKSTVVAAL
                     GDDRPRTLALAAGLGAASSSCSYAAVALARSLFRKGADFTAAMAFQIASTNLVVELGII
                     LALLMGWQFTAAEFVGGPVMIVVLALLLRAFLTPALLRAARAQADRGLAGSMEGHAAMD
                     MSVRRGGSFLRRLCSPEGVTATAHVFVMEWAAILRDLVAGLLVAGAIAAWVPDAFWRSF
                     FFDGHPLAAKFWGPLVGPLVAMASFVCSIGNVPLAVVLWKGGISFGGVVAFVFADLLIL
                     PILGIYRKYYGTRMALLLLGTFYVASAVAGYVVEFVFGGLGLVPDQARARIPQEGVTLN
                     YTTWLNVAFLALAAALLVRFFRTGGREMLRTMGGAPAGGRDDGHGDPAGRHGP"
     gene            2670..3251
                     /locus_tag="P0D74_RS37925"
     CDS             2670..3251
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016573306.1"
                     /locus_tag="P0D74_RS37925"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_275466699.1"
                     /transl_table=11
                     /translation="MQILVFPEAATPAELRTQVRELQDQAWPSERGTAPGPTEPVHDPA
                     LRPRSMLLVDDGTVLAALDVLAKEIRHAGCDYTAGGLSTVVTRLEARGRGHGRRLVTAA
                     REALATGGYDLGLFTCDRPLRAFYESAGWHHLPGTVLVGGTPQAPFPSDRPGFDKVTMA
                     DFFSPRARQARAAFRDSRIALHPGNIDALW"
     gene            3359..4213
                     /locus_tag="P0D74_RS37930"
     CDS             3359..4213
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016573305.1"
                     /locus_tag="P0D74_RS37930"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF4344 domain-containing metallopeptidase"
                     /protein_id="WP_275466700.1"
                     /transl_table=11
                     /translation="MGRWTGHTTRALLALTLAAAVTGCTAGRDAAESADDAGRRSYGKG
                     GSNGFVVQYRTGGRAATATGYLRAHRILDAAADRLNATLKVPQRIPFVVRSCGAAEPAY
                     DPETGTIDFCAEHVDEIRERFRQAGPGPDRPGGTAAADAHVAAVLEETAYHEGAHALID
                     RLGLRFTGREEDVADQFAAVLLIGQGRAGERKARAAADDYALAAEATPLDAADLRDEHS
                     LDGQRAANYACYVYGAHPDRHEDLVGSDARLDAERAEGCPDEWAQARDGWRQLLTAHLK
                     RPL"
     gene            complement(4292..4885)
                     /locus_tag="P0D74_RS37935"
     CDS             complement(4292..4885)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004942184.1"
                     /locus_tag="P0D74_RS37935"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_275466701.1"
                     /transl_table=11
                     /translation="MPTGVAIRDVREQLFGAAERILLRAGPNALTSRAVTTEAGCAKGV
                     LHRHFADFDAFLAELVRDRIGRIENQATALRAAAGTGAVADRLTAALLDVFGPVAVAIV
                     SLVISRDGLRAQLRAGGSTGVPLLAEATAMLASYLTAERALGRVAADADVDVLAPTLIG
                     AGHLLFADREGTAPDAPAVHRVVTAVIAGVVREP"
     gene            4975..5802
                     /locus_tag="P0D74_RS37940"
     CDS             4975..5802
                     /EC_number="2.1.1.-"
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016467788.1"
                     /locus_tag="P0D74_RS37940"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_275466702.1"
                     /transl_table=11
                     /translation="MPTMPPSGLPEARQHRQVAESFGTDAARYDRARPRYPDALVRRIA
                     AGLPVPDVPDVLDVGCGTGIAARQFRAAGCRVLGVEPDARMADVARALGTEVDVARFED
                     WDPADRTFDAVVAGTAWHWIDPVAGAERAARVLRPGGLLAPFWNVFRFPDDVADAVVGA
                     CRRTLPDAPFDVTAMTKCALDAYQQVCARAADGIRDAGGFDEPQQWRHDWEWTYTRDAW
                     LDQMPTLGAFTRIPPAALSDVLAGVGAAIDARGGSFTMGYATVALIAVRTETA"
     gene            complement(5896..6276)
                     /locus_tag="P0D74_RS37945"
     CDS             complement(5896..6276)
                     /GO_function="GO:0005515 - protein binding [Evidence IEA]"
                     /GO_function="GO:0070064 - proline-rich region binding
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016573302.1"
                     /locus_tag="P0D74_RS37945"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="SH3 domain-containing protein"
                     /protein_id="WP_275466703.1"
                     /transl_table=11
                     /translation="MTHLSPFRRGAAVLACAGFLCGVLGTGTAAAASPAAATAGGGHGP
                     SKGRVIAKNGLELRDGPGTAYRAVGSLPYGTVVTLRCKVNGENVHGNPRWYQVGEGRVT
                     WLSARYVETLGTAPRWCADRHR"
     gene            complement(6447..7100)
                     /locus_tag="P0D74_RS37950"
     CDS             complement(6447..7100)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016573301.1"
                     /locus_tag="P0D74_RS37950"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF3558 family protein"
                     /protein_id="WP_275466704.1"
                     /transl_table=11
                     /translation="MDQWDEDKQDWLEQARPVGAPPDGRSRRMLIVTGSAVVLVAAAVV
                     GLWQLARDGQPDSPGWSGAPPSAPGGGWSSSPGGGSVSSPGSDGLAAAPDPCAALDANT
                     AAAWGLSAGRPNNPSAPQAGLKACSWSGTVGGAALTYTLIYAKDIPVSPEPTPTSVTGV
                     PSASVLGNDQGCAIVWPTSFGKVFVHVKADTGTQPNLCDSAATFATQVAPRVPS"
     gene            complement(7112..7720)
                     /locus_tag="P0D74_RS37955"
     CDS             complement(7112..7720)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="P0D74_RS37955"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_275466705.1"
                     /transl_table=11
                     /translation="MTVQEPEPVHGREIGDDVTDAAPPGDATTGGNQAGGGISIGVLTG
                     GAVAAGERAAAEDHSVRDGRPAPALPPAGGPEAPAVPTSSAGGISIGVMTGGAAAAGAD
                     ARALDASTQPALDAPPELRAALGTLRQHLPLLTATDETSEIDARLADAEEEIDGTGRVR
                     RDRLQWLRDRLDLGATAVAGLASATAVVQQITQLLGGQG"
     gene            complement(7717..9465)
                     /locus_tag="P0D74_RS37960"
     CDS             complement(7717..9465)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016575712.1"
                     /locus_tag="P0D74_RS37960"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_275466706.1"
                     /transl_table=11
                     /translation="MILSFPEKPATAPSNTPSPTDPSSPSDGPPSEQGLSEATRLLCAG
                     VYFDGQFRRRVIQELVEHEERPIAPSLGFDALPVLAHALSARRREAQTGLLLLAVWALF
                     IGLDLADVGAQSLLPVPWFVAYGAVCVVSWVVRGTRSSLFALGRSVLKEATRGRLKAVL
                     PVLPFVVAVVYGAAVLTTLFRGGDAWIAVVFPVLLVPPIWAHRAHVVSVMRHQLGRETF
                     AQGRRAALPATAQYRRIGAAIAREQHARLAIYDPFRPFVGAGTPYKPWSVAMELKQQSW
                     AGSPEREAPESPSRPAPPSFTKRRPGSVPAPLTGREVVDLIKPRLEALRTSAAATSRDR
                     LRSLEVEELVYLPVGLARDEVDYGPDVIREHLERAVGEGAEARRHFLRVRVGAWDEQVA
                     ICLLVRIHTQGGMLVLEVAPHVLTPVRPEFKSVDVVAAHGGDGPLRDVIRSVLTSPSAG
                     CAAAVSLCQTAVSLMRTWLTMPEHALPDAPVASVRELGSAPELSLFQEMDISRYVKTLQ
                     DRIANGVQEALRNKGYETGVFDQYIINVGEGGVFIGGMSGGAVASGERALAKHTDASTE
                     TGGGRG"
     misc_feature    9571..9584
                     /note="TFBS match to RpoN, Regulator of nitrogen
                     assimilation and virulence, confidence: medium, score:
                     16.16"
                     /tool="antismash"
     misc_feature    9860..9874
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 17.76"
                     /tool="antismash"
     misc_feature    complement(9864..9878)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 16.23"
                     /tool="antismash"
     gene            10001..10984
                     /locus_tag="P0D74_RS37965"
     CDS             10001..10984
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010475286.1"
                     /locus_tag="P0D74_RS37965"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="thiopeptide-type bacteriocin biosynthesis
                     protein"
                     /protein_id="WP_275466707.1"
                     /sec_met_domain="Lant_dehydr_C (E-value: 3e-07, bitscore:
                     29.2, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLMVTDLLADCLRNAGALEISALPACADASELAEARTAFLAAGLA
                     AVRQRTVGTSWVQFNLAPAPDDHLPAYDWLGTVARELLDTGRAHNFFFMHKEPGLRMRF
                     EAPDGEREVLRSELAHHFVERGGWRQPPLGVVYEPEQYLFGGRASMPYVHRLFTHDSLA
                     WLDHHARHPCPEGEATAWRRSLFMLREVFAGLGVVGWEHRGVWDVVREDTGRQLTAAAR
                     DGHGPAGGTAWRRAAEGIREFWTRPGERMLASFPEEQRASLAEGAAALGEAARRWRTGY
                     FESGAASTGPRRAAAYAVVFHWNRARMSFARQCLLAEALADDGEAR"
     gene            10981..13875
                     /locus_tag="P0D74_RS37970"
     CDS             10981..13875
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF016615.3"
                     /locus_tag="P0D74_RS37970"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_275466708.1"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 3.9e-25,
                     bitscore: 87.3, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_N (E-value: 2.5e-11, bitscore:
                     41.3, seeds: 73, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTRRAPDTAGARPPAVAARPTGTVGPTALVRIAGLPGTLWASAGN
                     EPLFTWAADLAERDALHTARARALGDRLGIDVVPNPRLADAARGAVLALRRRLHAGTAP
                     GPADLPALETVAGVDPLLADALTELADRAADLAAARAACAAAVATDRARVGRLALDLLH
                     HDPVLRGHLGATAPRIAADFPRRAAAGEPWHSKRLRKYTGYVWRVAARAAAKTTPRDWL
                     GQLAAVPVFPAPALGAAAAGDSLVVPPARAGAGATSSMENVHLLWERLRDAGPAAAGPG
                     SLLALTPLHCPMPTGVLRCAVVDTGSRGSRLRRIELRRTPVLDAVLALLSPGPRPFAEV
                     EALIAARLNTPANGTPEGRRRATTALREFLQHLLRLGVLQLCAAPAQRRTNWTPAARIH
                     PPHHALDDHPAPATAAAPDARPGPGPHATDAAPPHQDATWFVDSYRTLDARLDALALAR
                     ITRGLRLATRLAALRAEDRPPTDPTGTTPQPYPGPADIGPAPRSVAELLTAPPADPCAE
                     TDRPTTATTRRRYEGWHPARTPGSGYAHLLAHLAAHLDDARIDLDGPLLDACHAPPEDP
                     EILAAWPADCLLRPLDAEGPVAVLETVSPAGVLDARFAEALHALHAGRGGYPQPAAYRA
                     FLAALERAADVRFVEVLVPPLDARAANAVRRPVLTDWSTGDANTALYYGSYGDGEACGA
                     VAAATPRPPGGNAPRPVRHLPLDRLTLRSDGRHLIAEVDGARVFPVHHATRNPAPPYDR
                     LTRLLMAAAHPATQHVVQLGGLIGAFPTAGRVPRLSVGGDLVVSPAAWRVPVAELWEPK
                     AREADKVTALAVLRRTRQLPRFCFARPAPGAKPVPVDLAALPALHVLERLRAAAPDGAL
                     IIEEALPAPGRSPVRDAVHGGAPVAAQVQLRTPYDAHPEELAARAAAALRHWTAPPPPR
                     PRPQTTPDAPPEGRPPGRNRTPRKGGQSCPQPSN"
     aSDomain        11872..12138
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_P0D74_RS37970_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="1.30E-27"
                     /identifier="RREFam001.1"
                     /label="P0D74_RS37970"
                     /locus_tag="P0D74_RS37970"
                     /protein_end="386"
                     /protein_start="297"
                     /score="87.3"
                     /tool="antismash"
                     /translation="LRCAVVDTGSRGSRLRRIELRRTPVLDAVLALLSPGPRPFAEVEA
                     LIAARLNTPANGTPEGRRRATTALREFLQHLLRLGVLQLCAAPA"
     gene            13854..14024
                     /locus_tag="P0D74_RS37975"
     CDS             13854..14024
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018569785.1"
                     /locus_tag="P0D74_RS37975"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_020930403.1"
                     /transl_table=11
                     /translation="MPTTIELTDLDNLIGDLDARITESELPSAEAYTGGCSGVCTVIVC
                     DTVLFCSGVVC"
     CDS_motif       13854..13949
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MPTTIELTDLDNLIGDLDARITESELPSAEAY"
                     /locus_tag="P0D74_RS37975_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       13950..14024
                     /prepeptide="core"
                     /locus_tag="P0D74_RS37975_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class I"
                     /score="-11.60"
                     /molecular_weight="2232.7"
                     /monoisotopic_mass="2231.0"
                     /core_sequence="TGGCSGVCTVIVCDTVLFCSGVVC"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MPTTIELTDLDNLIGDLDARITESELPSAEAY"
                     /leader_location="[13853:13949](+)"
     gene            14156..15433
                     /locus_tag="P0D74_RS37980"
     CDS             14156..15433
                     /GO_process="GO:0031179 - peptide modification [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018569784.1"
                     /locus_tag="P0D74_RS37980"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lanthionine synthetase LanC family protein"
                     /protein_id="WP_275466709.1"
                     /sec_met_domain="LANC_like (E-value: 6.3e-20, bitscore:
                     70.2, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPLHSRTGHTAAVHPRPSPAREARWRAHALQDAVLLLDRYVERAG
                     TGQTPGAGGHPSDPGVPVLARLVADRGDPVATAAASRATAVWARTAGRGAGHPGLYDGG
                     LAGTLVGLRQAATLHPALHQVADRLADRLPARILAGAARTTPGAVTFRDYDLILGPAGT
                     LLALSSAAPERHRVLVRLGRCLAALCAADGLDGLRTHYPEHPQLGWLDGRINTGTGHGV
                     AGVLTALAVAARQAEEGDASAAPELAAALRRTSRWLRGQSFVDARGIRSWDGAGPEAAP
                     PGGARRRQAWCYGAPGVSWALWDAGDTLRDPAVRDFAGAAFDTLAAGYDEDFHLFGDHL
                     GDRLGLCHGAAGVLAVADALHRHARLPSAAALRARLLARLDAHRAGTRALGEERMGLLG
                     GAGGTLSAVLTATGGARDWLPCLGLR"
     gene            15477..15680
                     /locus_tag="P0D74_RS37985"
     CDS             15477..15680
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018540669.1"
                     /locus_tag="P0D74_RS37985"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_275466710.1"
                     /transl_table=11
                     /translation="MSDMNDRLLSLVDGVVDLDEERLPLLTLREAQAAIELLRLLAAGD
                     GEGSHAARHLARNLGRRMPSEH"
     gene            15750..16919
                     /locus_tag="P0D74_RS37990"
     CDS             15750..16919
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) MGT"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1062: glycosyltransferase, MGT family"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016577787.1"
                     /locus_tag="P0D74_RS37990"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="macrolide family glycosyltransferase"
                     /protein_id="WP_275466711.1"
                     /sec_met_domain="MGT (E-value: 9.5e-43, bitscore: 145.9,
                     seeds: 193, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAKHLLFVALLGHGHINPTLPLVEELVRRGHRVDYATSAEHAEAV
                     TRSGAHWVELPPLPPIDRPTEFGPETFGRFMRHLFAGMRTAYPVLRDHCATTPVDAICY
                     DAMNWSARVLAEELDLPAVRLIPNFASNETYSLFAQFMTGTDGVHPVTAAIGADCAQFA
                     AEHGVALDPAHLLDATEKLNLVFIPREFQPAGDSFDERFHFIGPSLGSRADEPWSPPDP
                     EAPVLFVSLGTVFNDRPEFYRTCIDAFADEPYHVAMSVGGLDPAALGPIPASFDVRARF
                     PQPAVLQRATAFVSHTGMNSTMEALYYGVGLIAVPQMPEQAANAGRVQELGLGEQLDAR
                     TVTAEALRAAVARVASDDAVRANLDGMRKVVRESGGAVRGVEVIEEYLR"
     misc_feature    15765..15767
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(16969..17853)
                     /locus_tag="P0D74_RS37995"
     CDS             complement(16969..17853)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016577786.1"
                     /locus_tag="P0D74_RS37995"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="RNA polymerase sigma factor SigF"
                     /protein_id="WP_044372419.1"
                     /transl_table=11
                     /translation="MTIVVNDTADPAQTTARDDGLPEVRRPRAVAPRDARALSKQFFDR
                     LQELEEGTHAYQYARNTLIEMNMSMVRYVARRYRHRGDDMEDIVQVGTIGLIKAIDRFD
                     LSREVEFSTFAVPYILGEIKRFFRDTGWAVHVPRRLQELRTELAKAKEQLHAALDRDPT
                     VAELAAHLKLSEEEVIEGLVAANGYSADSLDTPADPDPGDQRRALTEVLGAHDPALETV
                     EDLHTLAPLLRQLDARERRIIELRFGQEMTQSQIGAELGVSQMHVSRLLNRTLSRLRTG
                     MLKDGAPAPSPGS"
     gene            complement(17985..18374)
                     /locus_tag="P0D74_RS38000"
     CDS             complement(17985..18374)
                     /GO_function="GO:0043856 - anti-sigma factor antagonist
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016577785.1"
                     /locus_tag="P0D74_RS38000"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="STAS domain-containing protein"
                     /protein_id="WP_275466712.1"
                     /transl_table=11
                     /translation="MLRADLLSVEVTVVDERTAVAAVCGELDTATGTALHHQLANQLAH
                     GRRHLVLDLRDVPFMDSSGLGVIIRVHNDTKKVGGSVQLAAASPVVRRLLDLTGISVSM
                     PVQDTPEEALFALATASLPGPTSFS"
     misc_feature    complement(18559..18572)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 19.13"
                     /tool="antismash"
     gene            complement(18647..19018)
                     /locus_tag="P0D74_RS38005"
     CDS             complement(18647..19018)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016577784.1"
                     /locus_tag="P0D74_RS38005"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ATP-binding protein"
                     /protein_id="WP_275466713.1"
                     /transl_table=11
                     /translation="MALTAELPATSGEARDRVLALLRTGHRQVDDVVVADALLITSELV
                     TNALRHAGGVTGFTSRISGDRLEVTVEDASPVHPFVPSDTRDGRIGGYGWSLVGRLATS
                     VVITSTAFGKVIHVTLRLR"
     gene            complement(19140..19511)
                     /locus_tag="P0D74_RS38010"
     CDS             complement(19140..19511)
                     /GO_function="GO:0043856 - anti-sigma factor antagonist
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016577783.1"
                     /locus_tag="P0D74_RS38010"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="STAS domain-containing protein"
                     /protein_id="WP_275466714.1"
                     /transl_table=11
                     /translation="MTDPSPARILHLSSTAVGPDVLRITVRGELDVDSAAEFQDAVTEH
                     LAAHTGLRALRVDCGGLVLRDCMGLSALLMVHRRTTALGVSLHLEERPPALDRLLAVTG
                     TLDHLTAPPAAAASTPPSS"
     gene            complement(19508..20635)
                     /locus_tag="P0D74_RS38015"
     CDS             complement(19508..20635)
                     /GO_function="GO:0031419 - cobalamin binding [Evidence
                     IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016577782.1"
                     /locus_tag="P0D74_RS38015"
                     /note="Presence of a B(12) (cobalamin)-binding domain
                     implies dependence on cobalamin itself, in one of its
                     several forms, or in some unusual lineages, dependence on a
                     cobalamin-like analog.; Presence of a B(12)
                     (cobalamin)-binding domain implies dependence on cobalamin
                     itself, in one of its several forms, or in some unusual
                     lineages, dependence on a cobalamin-like analog.; Presence
                     of a B(12) (cobalamin)-binding domain implies dependence on
                     cobalamin itself, in one of its several forms, or in some
                     unusual lineages, dependence on a cobalamin-like analog.;
                     Presence of a B(12) (cobalamin)-binding domain implies
                     dependence on cobalamin itself, in one of its several
                     forms, or in some unusual lineages, dependence on a
                     cobalamin-like analog.; Presence of a B(12)
                     (cobalamin)-binding domain implies dependence on cobalamin
                     itself, in one of its several forms, or in some unusual
                     lineages, dependence on a cobalamin-like analog; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology."
                     /product="cobalamin-dependent protein"
                     /protein_id="WP_275466715.1"
                     /transl_table=11
                     /translation="MTTSSAPPAPLTAGDQVPSCANRLWEAVRAGDEHAAGTGVLDALT
                     DGVPPETLLLDVIGGVQRRVGVEWAANRLSVAQEHAATAINEQVIALLAQHPDIPPVPP
                     ARGRITVACVDGEWHALPARLLAEVLRLRGWRVDYLGAQVPAPHLIAHLHLTNPDLVAL
                     SSSLVTRLPAAHATITACQATGVPVLVGGAAFGSDGRHARQLGADAWAPDARQAAERLQ
                     RPLTRRKADHQAIDDLPHLADQEYTLVARGSRQLVREVLAGLETRFPALLDYDDGQRDH
                     TAQDVAHLVEFLTAALYTDDTELFSGFLAWTADVLRARAVPPESLLPALDLLERALRDF
                     PRAVGLITRSRQALSRALRASGPPATERLDPGQPA"
     gene            complement(20632..22197)
                     /locus_tag="P0D74_RS38020"
     CDS             complement(20632..22197)
                     /EC_number="3.1.3.16"
                     /GO_function="GO:0004722 - protein serine/threonine
                     phosphatase activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1054: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016577781.1"
                     /locus_tag="P0D74_RS38020"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="PP2C family protein-serine/threonine phosphatase"
                     /protein_id="WP_275467817.1"
                     /transl_table=11
                     /translation="MADPVGTVRRANEAFGLLVPDAVEGSALREVLPGWLLLAHDRLSA
                     APAPHAPPPRGEVAGRSFEAHATRLPEGEVVWWLTDDTDARLAERRLLQERNRTAFLAR
                     ASNELLSSLNLDRCMEVAGRLAAAHLADAAVVIAPPRGRVLSVVSADGTGAHIRQLTGV
                     APESVPGLAEALRGFPPAPSRWIDPAAAPEWLVPEDFGPVGAMVVTPLPGHGVPAGALV
                     LLRRAHHAAFSESEESFARLFAARAGAAMSAARLYAEQAQITETLMRELLPPRVGQVGG
                     VEFAARYRAAKDGERVGGDFYDIHPAAAPQDESLVVLGDVCGKGLDAAVLTGKIRNTLH
                     ALLPLSGDHVRMLRLLNGALLSSHHTRFATLVVASARRRADRVELRVTCAGHPAPLVVR
                     ADGRVAEVETHGNLVGVLPEIDAVTAPLTLAPGESLVLFTDGITESKGGPLGDELFGDA
                     RLRRALAHCAGMPAEAVAEHVQMLATEWVGVNKHDDMAVVTVTAPRGSSRRAPGGTPTE
                     GHGA"
     gene            22562..22912
                     /locus_tag="P0D74_RS38025"
     CDS             22562..22912
                     /GO_function="GO:0043856 - anti-sigma factor antagonist
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007268254.1"
                     /locus_tag="P0D74_RS38025"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="STAS domain-containing protein"
                     /protein_id="WP_233656049.1"
                     /transl_table=11
                     /translation="MHAPTPAVVTHAVEDQVFVIRVTGSLDHESAALLEEACALAESHA
                     ARRTVVDLSLTDFADSTVLHVLLGAQRAHHRRQRRLLVAGPFQPVVRRLFEVTGTTDYF
                     TLVDNVPTAVQE"
     misc_feature    complement(22611..22626)
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 22.02"
                     /tool="antismash"
     gene            complement(22973..24013)
                     /locus_tag="P0D74_RS38030"
     CDS             complement(22973..24013)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014057360.1"
                     /locus_tag="P0D74_RS38030"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="YafY family protein"
                     /protein_id="WP_275466716.1"
                     /transl_table=11
                     /translation="MTTTTTRVLALLEILQGGGIHTVPDLAARLAVDERTVRRYVGHLL
                     DLDVPVDAVRGRYGGYRLAPGYRMPPLMLTDEEALAVVLGLLAAQSAGLVTTSAAASES
                     AAAKLRRVLPKPLARRLAALLETADVTARPHPGAAPETAVLLGLAEATHQQRPVALTYT
                     DRKGRRTDRTVLPYGLVAHAGRWYLAGADPTAGDGGVRTFRLDRISALSVRSGSFVVPA
                     TFDPVTRVLTGLARTPWAHEVSLRVRADVPHVRRHLPADLATVSPIAAAAGTDDADPAE
                     RDGEPDGTPEADLDGWVRVRMRAERLDWIPPVLAALDRPFVIEHPAELRDLVRALARRL
                     DACADQ"
     gene            24119..24517
                     /locus_tag="P0D74_RS38035"
     CDS             24119..24517
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016577778.1"
                     /locus_tag="P0D74_RS38035"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="VOC family protein"
                     /protein_id="WP_275466717.1"
                     /transl_table=11
                     /translation="MNLVSLRMITHDVARLVAFYEGVTAVPATWSTPEFAELVTEACTL
                     AIASDRTVALFGADSARPAANRTVITEFRVADVDAAYARLTSLDCVFVQRPTTMPWGNR
                     SLLFRDPDGNLINFFTPVTPEAVRRQER"
     misc_feature    24120..24134
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.31"
                     /tool="antismash"
     gene            complement(24606..25208)
                     /locus_tag="P0D74_RS38040"
     CDS             complement(24606..25208)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016577777.1"
                     /locus_tag="P0D74_RS38040"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_275466718.1"
                     /transl_table=11
                     /translation="MPKQVDHRERRETIARALWRVVEERGIAQASVREVAQEAGISHGA
                     VQHYFATREEMVVFAMDFASAQTSLRVAEGVSALGDPPHPRDLLRVMLVEMLPLRPDAR
                     TTSRMSAAYVLEALHDANIRTRARDGLAHGRDLVERIVRQAVTDGHLSPDRDPATETNL
                     LLALTGLTPLVELGVIEPQEALTAVDQHLNRLFGKGT"
     misc_feature    25222..25240
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 17.56"
                     /tool="antismash"
     misc_feature    complement(25226..25244)
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 17.28"
                     /tool="antismash"
     misc_feature    complement(25232..25248)
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 18.6"
                     /tool="antismash"
ORIGIN
        1 cctggaagtc ctggtcggag tggtcgtcgt gcagcttcag tgtgaccgcg cggaacgcgg
       61 cgtgttcggc ggcggagccc cgcgcggggg tgtcgtcgtc atcgtcgtcg tggtcatcgt
      121 ggccgtccgg ccggtgcggc gcgcgggcga agtcggccag cggcggggcg tggtggaggc
      181 cgtcgccggc ggccagcacc ttgcggtcgg cgtcgaccac ctgcaccggc cggtcgtcct
      241 cgtcgggcat gttgaggtgg tcgaagggtg tgccgaccgc gacctgggtg gcgacctcgc
      301 gggcgaccac ctccgcctgg aggccggcgc tgtcgacgag gttgcgctgg agcaccccga
      361 ggaccgcggc cccggcggcg accagggcca gcgccaccac cagggtggag gccaaggtgg
      421 tgcgggcccg gacggacccc caccagcggg gctggcgcgg ctgcgacggc gccgcggtgg
      481 tctgctcagc cacggtcggc cgccagccgg taaccggcgc cgcgcacggt ggtgatcgag
      541 cgccggccga acggggcgtc gatcttccgc cgcagggcgc tgatgtagac ctcgatgatg
      601 ttcgggtcgc cgtcgtaggc gaagtcccag acgtgctcca atatctctgc tttggagacg
      661 acatgtccgg atcgcgaagc caggtactcc agcaccgcga actccttggc ggtgagcggg
      721 atctcctcct cgccgcgggc gcaacggtga ccgttcgggt ccagcaccag gtcaccgagg
      781 cgcaggacgg ggctgccgcc gcgcgtccgg cggcgcagca gcgcccggac gcgggccagc
      841 aggaccacgt aggagaacgg cttggtgagg tagtcgtcgg cgccggtgtc cagcccctcc
      901 gcctcgtcgt actcgccgtc cttcgcggtc agcatgagga tcggggtttc gtcaccggcc
      961 gcgcgcaggg ccgcgcagac gcggtagccg ttcatcccgg gcagcatgat gtccaggatg
     1021 agcaggtcgt agccctgggt ggtggccagg tgcagaccct cccggccgtc gtgtgccacg
     1081 tccacggcga agccctccgc cgccagcccc ttggccaggg tggtggcgag gcgtttttcg
     1141 tcctccacga tcaacaagcg catgacgtca gactgccaga acgttcctga agggctcttc
     1201 aggtagcttc aggtgggctt cagccaggga gcgtcacggc ggtgaccgcg cccctgacgc
     1261 accgtcggtc ggagcggcac cggccgccgg tgcgacggtc ccgacgacgc gcacgacgag
     1321 cggccggtgg cgcgccctgt cacgggccgt gccgacccgc tgggtccccg tgcccgtcgt
     1381 cgcgcccacc ggcgggggcg ccgcccatcg tgcggagcat ctcccggcca ccggtgcgga
     1441 agaaccgcac caacagggcc gcggccaggg cgaggaaggc cacgttgagc caggtggtgt
     1501 agttcagggt gacgccctcc tgcgggatcc gcgcccgggc ctggtccggg acgaggccga
     1561 gcccgccgaa gacgaactcg accacgtacc cggcgaccgc gctcgcgacg tagaaggtgc
     1621 cgagcagcag cagtgccatc ctggtgccgt agtacttccg gtagatgccg aggatcggca
     1681 ggatcagcag gtccgcgaag acgaacgcca ccaccccgcc gaagctgatc ccgcccttcc
     1741 acaacaccac cgcgagcgga acgttgccga tggagcagac gaacgacgcc atcgcgacca
     1801 ggggaccgac gagcggcccc cagaacttcg cggcgagcgg atggccgtcg aagaagaagg
     1861 accgccagaa ggcgtcgggc acccacgccg cgatggcacc ggcgacgagc agaccggcca
     1921 ccaggtcccg caggatcgcc gcccactcca tgacgaagac gtgcgcggtg gccgtgacgc
     1981 cctcgggcga gcacagccgg cgcaggaagg agccgccgcg ccggacggac atgtccatcg
     2041 cggcgtgccc ctccatcgaa ccggccaggc cgcggtcggc ctgagcccgg gccgcgcgca
     2101 gcaatgccgg cgtcaggaag gcccgcagca gcaacgccag caccacgatc atgaccggcc
     2161 cgcccacgaa ctcggcggcg gtgaactgcc accccatcag cagcgccagg atgatgccca
     2221 gttccacgac cagattggtg gaggcgatct ggaacgccat cgcggcggtg aagtccgccc
     2281 ccttgcggaa cagtgaacgg gccagcgcca ccgcggcgta ggagcacgag gacgaggccg
     2341 caccgagccc ggcggcgagt gccagggtgc gcgggcggtc gtcaccgagc gccgcgacca
     2401 cggtggactt gcggaccacc gcctggacca ccgcggacag gccgaagccc aggatcagcg
     2461 cccaggtgat ctcccaggtc atcgagccgg tgagggacag tgcgtggagg acggcggaca
     2521 tgcccgcatc ctttcccggg cgtccggccc cgccgcggac ggacacgcgc gggccccgag
     2581 cggccgccgg cccctcgccg ccgggccggc ccgggtcacc cgggacgatc cgtcgtgccg
     2641 cccgcacccc gctggtacac aatcggcggg tgcagatcct cgtgttcccc gaagccgcca
     2701 cccccgccga actccgaacc caggtgcggg agctccagga ccaagcgtgg ccctcggagc
     2761 ggggcacggc ccccgggccc accgagccgg tccacgaccc cgcgctgcgg ccgcggtcga
     2821 tgctgctggt cgacgacggg accgtcctcg ccgcgctgga cgtcctcgcc aaggagatcc
     2881 ggcacgccgg ctgcgactac accgccggtg gcctgagcac ggtcgtgacg cgcctggagg
     2941 cgcgcggccg ggggcacggc cggcggctgg tgaccgcggc ccgggaggcg ctggccaccg
     3001 ggggttacga cctggggttg ttcacctgcg accgaccgtt gcgcgccttc tacgagagcg
     3061 ccggctggca ccacctcccg ggcaccgtcc tcgtcggcgg aaccccgcag gcccccttcc
     3121 ccagcgaccg gcccgggttc gacaaggtca ccatggcgga cttcttctcg ccgcgcgccc
     3181 ggcaggcccg ggccgcgttc cgcgacagcc gcatcgcgct gcaccccggg aacatcgacg
     3241 cgctgtggtg attcccgtcc gatccgccac cggcgtggaa ccgccagctc cgcacacgcc
     3301 tcttccctgc tcggacggac cgccgcggtg cgcggcccag gcagtgagga gcaggcggat
     3361 gggccgctgg acggggcaca ccacacgggc gttgctggcc ttgaccctgg cggccgcggt
     3421 gaccggctgc acggccgggc gggacgcggc cgagtcggcg gacgacgcgg gccgccggag
     3481 ctacggcaag ggcggctcga acggcttcgt cgtgcagtac cgcaccggcg gccgggcggc
     3541 gaccgccacc ggctacctcc gcgcgcaccg catcctggac gcggccgccg accggttgaa
     3601 cgccaccctc aaggtgccgc agcgcatccc gttcgtggtc cgctcgtgcg gtgcggccga
     3661 acccgcctac gacccggaga ccggcaccat cgacttctgc gccgagcacg tcgacgagat
     3721 acgcgagcgc ttccggcagg ccggcccggg ccccgaccga ccgggcggca cggcggccgc
     3781 cgacgcccat gtggccgccg tgctggagga gaccgcctac cacgagggcg cccacgccct
     3841 gatcgaccgc ctcggcctgc gcttcaccgg ccgggaggag gacgtggccg accagttcgc
     3901 cgcggtgctg ctgatcggcc agggccgggc cggcgaacgc aaggcccgcg ccgcggcgga
     3961 cgactacgcc ctggccgccg aggcgacccc gttggacgcg gccgacctgc gcgacgagca
     4021 cagcctcgac ggccagcgcg cggcgaacta cgcctgctac gtctacggtg cgcacccgga
     4081 tcggcacgag gacctcgtcg ggagcgacgc ccggctcgat gcggagcgcg ccgagggctg
     4141 ccccgacgaa tgggcgcagg ccagggacgg ttggcggcaa ctcctcaccg cgcacctcaa
     4201 gcgccccctg tgacgtcgcg ggcgcacggg cgctgacgtc cggcctccga gcctccgccc
     4261 aggcgctacg gcacccgccg ccgggcccgc gtcacggttc gcgcaccact ccggcgatga
     4321 ccgcggtcac gacccggtga acggccggcg cgtccggcgc ggtgccctcc cggtccgcga
     4381 acagcaggtg gccggcgccg atcagggtgg gcgcgaggac gtcgacgtcg gcgtccgcgg
     4441 cgacccggcc cagtgcgcgc tcggcggtca ggtaggaggc cagcatcgcg gtggcctcgg
     4501 cgaggagcgg gacgccggtc gaaccgccgg cgcgtagttg ggcgcgcagg ccgtcgcggg
     4561 agatcacgag cgagacgatt gccacggcga ccggcccgaa cacgtcgagc agcgcggcgg
     4621 tgaggcggtc ggcgacggcg ccggtcccgg cggccgcgcg cagcgcggtg gcctggttct
     4681 cgatccgacc gatccggtcc cgcaccaact cggcgaggaa ggcgtcgaag tcggcgaagt
     4741 gccggtgcag gacgcccttg gcgcagcccg cctccgtggt gaccgcgcgg ctggtcagcg
     4801 cgtttggccc ggcccgcagc aggatccgct cggcggcgcc gaacaactgc tcccgcacat
     4861 cgcggatggc cactcctgtc ggcacggtgc gccccttccc tcggttccct ccgtcggacc
     4921 ccgcgatcct cccatccggt tgacgagtgg gcatgcgccc atcatggtgg gcgcatgccc
     4981 actatgccgc cctcagggct ccccgaagcg cgtcaacacc ggcaggtggc ggagtcgttc
     5041 ggcaccgacg ccgcacgcta cgaccgggcc cggccccgct accccgacgc cctcgtgcga
     5101 aggatcgcgg ccggcctccc cgtccccgac gtccccgacg tccttgatgt cggctgcgga
     5161 acgggcatcg ccgcccggca gttccgcgcg gccggctgcc gggtgctcgg ggtcgaaccg
     5221 gacgcacgga tggccgacgt ggcccgcgca ctcggcacgg aggtggacgt cgcgcggttc
     5281 gaggactggg accccgccga ccgcaccttc gacgcagtgg tcgccggcac cgcctggcac
     5341 tggatcgacc ccgtcgccgg cgccgagcgg gccgcgcggg tcctgcgccc cggcggcctc
     5401 ctggcgccgt tctggaacgt cttccggttc cccgacgatg tggcggacgc ggtcgtcggg
     5461 gcctgccgtc ggacactgcc ggacgcgccg ttcgatgtca ccgcgatgac gaagtgcgcc
     5521 ctcgacgcct accagcaggt gtgcgcccgc gccgccgacg gcatccggga cgcgggcggc
     5581 ttcgacgagc cgcaacagtg gcgccacgac tgggagtgga cctacacccg ggacgcctgg
     5641 ctggaccaga tgcccaccct gggggccttc acccgcatcc cgccggccgc gctgagtgac
     5701 gtgctggcgg gcgtcggggc cgccatcgac gcgcggggtg gcagcttcac gatgggctac
     5761 gcgacggtgg cgctcatcgc cgtgcgcacc gagaccgcct gaaccgcgct ccggagcagg
     5821 gtggttgccc cggccgggcg gagcggcgcg gttccgtccc gcccgcacgc ggccgggacg
     5881 gaacccgccg acggatcagc ggtgccggtc cgcgcaccag cggggtgcgg tgccgagggt
     5941 ctcgacgtag cgcgccgaca accaggtgac ccggccctcc ccgacctggt accagcgcgg
     6001 attgccgtgc acgttctcgc cgttgacctt gcagcggagg gtgacgacgg tgccgtacgg
     6061 cagcgaaccc accgcccggt acgcggtccc gggaccgtcc cgcagctcca ggccgttctt
     6121 ggcgatcacc cggcctttgg acgggccgtg gccgccaccc gcggtggccg ccgcgggact
     6181 tgcggcggcg gccgtgccgg tgccgaggac accgcagagg aacccggcgc aggcgagtac
     6241 ggcggcgccg cggcggaacg gggacaggtg tgtcatgacc gacctcccga tcgcgatcca
     6301 tccggctgtc cggacggttc gatgccagac cagaattccc cgaccggcct ccggatcctt
     6361 cgtcgggcga gcgaattcac cggcacggga ccgcctcgaa tacctgcccg gagcggcggc
     6421 cacggcatcc ggcgtgcgag gaagcgtcag gacggcaccc tcggggccac ctgggtggcg
     6481 aaggtggcgg cggagtcgca caggttcggt tgcgtcccgg tgtccgcctt gacgtgcacg
     6541 aacaccttcc cgaacgaggt gggccagacg atcgcgcacc cctggtcgtt cccgagcacc
     6601 gacgcggacg gaactccggt gacgctggtc ggcgtgggtt ccggcgacac cgggatgtcc
     6661 ttggcgtaga tcagcgtgta ggtgagggcg gcgccgccta cggttccgct ccaactgcac
     6721 gccttcagcc cggcctgcgg agcgctgggg ttgttcgggc ggcccgcgga caggccccag
     6781 gccgcggcgg tgttcgcgtc gagtgccgcg cacgggtcgg gagccgcggc cagaccgtcc
     6841 gaacccggcg aggagaccga cccgccgccg ggactgctcg accaaccgcc gccgggcgcg
     6901 gagggcgggg cgccgctcca ccccggggag tccggttggc cgtcgcgcgc cagttgccac
     6961 agcccgacca cggccgccgc gacgagcacg accgcggagc ccgtcacgat gagcatgcgc
     7021 cgggacctgc cgtcgggcgg cgcaccgacc ggtcgcgcct gctccagcca gtcctgcttg
     7081 tcctcgtccc actggtccat gccgacccct cctagccctg gccgccgagg agttgggtga
     7141 tctgctggac gacggccgtc gccgaggcga gccccgccac ggccgtcgcg ccgaggtcga
     7201 ggcggtcgcg cagccactgc aggcggtccc gacgcacccg cccggtgccg tcgatctcct
     7261 cttcggcgtc cgccagccgg gcatcgatct ccgacgtctc gtccgtcgcg gtgagcaacg
     7321 gcaggtgctg acgcagggtg cccagtgccg cccggagttc gggcggcgcg tcgagcgccg
     7381 gttgcgtcga ggcgtccagc gcccgggcgt ccgcccccgc ggccgccgcg ccgccggtca
     7441 tcacgccgat gctgatgccg ccggcggagc tcgtcggcac ggcgggcgcc tcgggcccgc
     7501 ccgcgggcgg gagcgccggt gccgggcggc cgtcgcgcac cgagtggtcc tcggcggcgg
     7561 cccgctcgcc ggccgcgacc gcgccgccgg tcagtacgcc gatgctgatg ccgccaccgg
     7621 cctggttgcc gccagtcgtc gcgtcgccgg gcggggcggc gtccgtcacg tcgtcgccga
     7681 tctcccggcc gtgcaccggc tccggctcct gaaccgtcat cctcgaccgc cccccgtctc
     7741 cgtcgacgcg tccgtgtgct tggccagggc gcgctcgccg gaggcgaccg caccgccgct
     7801 catcccgccg atgaacaccc cgccctcgcc cacgttgatg atgtactggt cgaacacgcc
     7861 cgtttcgtag cccttgttgc gcagggcctc ctgcaccccg ttggcgattc ggtcctggag
     7921 cgtcttcacg taccggctga tgtccatctc ctggaacagc gagagttccg gcgcgctccc
     7981 caactcccgt acggaagcga ccggtgcgtc cggcagggcg tgttccggca tcgtcagcca
     8041 cgtgcgcatc agggacaccg ccgtctggca cagcgagacc gcggcggcgc atcccgccga
     8101 ggggctggtc agcacgctcc tgatcacgtc gcgcagcggg ccgtccccgc cgtgcgccgc
     8161 gaccacgtcc accgacttga actccgggcg caccggcgtc aggacgtgcg gggcgacctc
     8221 caggaccagc atcccgccct gggtgtggat gcggaccaac aggcagatcg ccacctgctc
     8281 gtcccaggca ccgacccgca cccgcaggaa gtggcggcgg gcctcggcgc cctcgccgac
     8341 ggcccgttcc aggtgctcgc ggatgacgtc cggcccgtag tccacctcgt cgcgcgccag
     8401 cccgaccggt aggtagacca gttcctcgac ttcgagggag cgcaggcggt cccggctggt
     8461 ggccgcggcc gaggtgcgca gtgcctccag ccggggcttg atcagatcga ccacctcccg
     8521 gccggtgagc ggggcgggga cgctcccggg ccgccgcttc gtgaaggagg gcggcgccgg
     8581 gcgcgacggg gactccggcg cctcccgctc cggtgacccg gcccaactct gctgcttcag
     8641 ttccatggcg accgaccacg gcttgtacgg cgtgccggcg ccgacgaagg gccggaacgg
     8701 gtcgtagatg gccagccggg catgctgttc gcgggcgatg gccgccccga tgcgccggta
     8761 ctgggcggtg gccggcagcg ccgcccgccg cccctgggcg aaggtctcgc ggccgagttg
     8821 gtgccgcatg acggagacga cgtgcgcccg gtgcgcccag atcggcggca ccagcaggac
     8881 cgggaacacc acggcgatcc aggcgtcgcc gccgcggaac agggtggtga gcacggccgc
     8941 cccgtacacc accgccacca cgaacggcag tactggcagc actgccttca gtcggccgcg
     9001 ggtggcctcc ttgagcaccg agcgcccgag agcgaagagg gaactcctgg ttccgcgcac
     9061 gacccaggac acgacgcaga ccgccccgta ggccacgaac cacggcacgg ggaggagcga
     9121 ctgcgcaccg acgtcggcca ggtcgagccc gatgaacagg gcccagacgg ccaacagcaa
     9181 cagcccggtc tgcgcctccc ggcggcgcgc cgacagcgcg tgggcgagga ccggcagggc
     9241 gtcgaagccg agcgagggcg ctatcgggcg ctcctcgtgc tcgaccagtt cctggatgac
     9301 gcggcgacgg aactgtccgt cgaagtagac ccccgcgcac agcaggcggg tggcttcgct
     9361 gaggccctgc tcggagggcg gtccgtcgga tggcgaggag gggtccgtcg gcgatggcgt
     9421 gttcgacgga gcggtcgctg gtttttcggg gaaggacaag atcatgcacc cccgtgatcg
     9481 aactcgtccc ctgttgcgag gtgttgacgg agttgctatg ggggcagtat gactccccgt
     9541 cgtcggaccc ggaaggggtt ccgccggctt ggcaactcct ttgctgcgac gatgagttga
     9601 cgcccaagac ggccgttgct cccggcgcct gcgcccgcgc gtgcgccggg agccacccct
     9661 ggggcgcgag gggcggtacg gccggaggcg cgggcggtgg cgggggagcc gggcgaaccc
     9721 ggcgggaggt tcgtcgcgcc cgggagcgct cggcgggcga aacgacgtcg ggccggtggg
     9781 aactcgcctt gcggtgccgt gccgtcgtgc accacggcgc aagccggcga tgcgagacct
     9841 cggacctccg gcgcacaact gctcaatata tgaagaatgc agataatgac gttatcggtg
     9901 agcgggccgg gaaggcgttt gggcggggcg attcgagccc cgcattcctg tgccccggcc
     9961 gaccggcggg gcttcggtgc tcggtgccgg aggaacgtac atgctgatgg tcacggacct
    10021 gctcgcggac tgtctccgca acgccggagc cctggagata tccgccctcc ccgcctgtgc
    10081 ggacgcttcc gaactcgccg aggcccgcac cgcgttcctg gccgccggcc tggccgcagt
    10141 gcggcagcgg accgtgggga cgtcctgggt ccagttcaac ctcgcgcccg cgccggacga
    10201 tcacctcccg gcgtacgact ggctgggcac cgtcgcccgg gaactcctcg acaccggccg
    10261 cgcccacaac ttcttcttca tgcacaagga gcccgggctg cggatgcggt tcgaggcgcc
    10321 agacggtgaa cgggaggtgc tgcgctcgga gttggcgcac cacttcgtcg aacggggcgg
    10381 ttggcggcag ccgccgttgg gggtggtgta cgaacccgag cagtacctct tcggcggccg
    10441 ggcgtcgatg ccctacgtgc accggctgtt cacgcacgac tcgttggcct ggctggacca
    10501 ccacgcccgc catccgtgcc ccgaggggga ggccaccgcc tggcggcgct cgctgttcat
    10561 gttgcgggag gtgttcgcgg gactgggcgt ggtcgggtgg gagcaccgag gcgtgtggga
    10621 cgtcgtacgc gaggacaccg gacgccagct caccgccgcc gcccgcgacg ggcacgggcc
    10681 cgcgggaggg acggcgtggc ggcgggccgc cgagggcatc cgggaattct ggacacggcc
    10741 cggcgagcgg atgctcgctt cgttccccga ggaacagcgg gcgtccctgg ccgagggcgc
    10801 cgcggccctg ggcgaggcgg cccgacggtg gcgcaccggc tacttcgagt cgggcgccgc
    10861 cagcaccggc ccgcggcgcg ccgccgccta cgcggtggtc ttccactgga accgggcgcg
    10921 gatgtcgttc gcccggcagt gcctgttggc cgaggcgctc gccgatgacg gggaggcccg
    10981 atgacgcgcc gcgcgccgga caccgccggc gcccgtccac cggccgtggc agcacgcccg
    11041 accggcaccg tcgggccgac cgcactggtc cgcatcgccg gactgccggg cacgctctgg
    11101 gcgtccgccg gcaacgaacc gctcttcacc tgggccgccg acctggcgga gcgggacgca
    11161 ctccacaccg cccgggccag ggcgctgggg gaccggctcg ggatcgacgt cgtgccgaac
    11221 ccgcgcctgg ccgacgccgc ccgcggcgcg gtgctcgccc tgcgccgcag actgcacgcc
    11281 gggaccgccc ccggacccgc ggacctcccc gccctggaga cggtggccgg cgtcgacccg
    11341 ttgctggccg acgccctcac ggagctggcc gaccgggcgg cggacctggc cgcggcgcgg
    11401 gccgcatgcg ccgccgcggt cgccaccgac cgcgcacggg tgggccggct ggccctcgac
    11461 ctgctgcacc acgaccccgt cctgcgcggc cacctcggcg ccaccgcacc ccggatcgcc
    11521 gcggacttcc cccggcgggc ggcggccggc gaaccctggc acagcaaacg gctgcgcaag
    11581 tacaccggct acgtctggcg ggtggccgcc cgggccgccg ccaagaccac cccgcgcgac
    11641 tggctcggcc aactcgccgc cgtccccgtc ttccccgcac ccgcactcgg cgccgccgcg
    11701 gccggtgatt ccctcgtcgt gccgcccgcc cgggccgggg ccggcgccac cagcagcatg
    11761 gagaacgtcc acctgctgtg ggaacggctc cgggacgccg gaccggccgc cgccggcccc
    11821 ggcagcctcc tcgccctgac gcccctgcac tgcccgatgc ccaccggcgt gctgcgctgc
    11881 gcggtcgtcg acaccggctc ccggggctcc cggctgcgcc ggatcgaact gcgccgcaca
    11941 ccggtcctgg acgcggtcct ggcgctcctt tcgcccggcc cccgcccgtt cgccgaggtc
    12001 gaagccctga tcgcggcgcg cctgaacacc ccggcgaacg gcacccctga agggcggcgg
    12061 cgggccacca ccgcgctccg cgagttcctc cagcacctcc tgcggctggg cgtcctgcaa
    12121 ctctgtgccg cgccggcgca acgccgcacg aactggaccc ccgccgcacg gatccacccg
    12181 ccgcaccacg ccctcgacga ccacccggcc ccggcgaccg cagcggcccc ggacgctcgc
    12241 cccggccccg gcccgcacgc caccgacgcc gcgccgcccc accaggacgc cacctggttc
    12301 gtcgactcct accgcaccct cgacgcccgc ctcgacgccc tcgccctggc ccggatcacc
    12361 cgcggcctgc ggctcgccac ccggctcgcc gccctgcgcg ccgaagaccg tccccccacg
    12421 gaccccaccg gcaccacccc gcagccgtac ccggggccgg cggacatcgg ccccgccccg
    12481 cgctcggtcg ccgaactcct gaccgccccg cccgccgacc cctgcgccga gacggaccgc
    12541 ccgaccaccg ccaccacgcg ccgccgctac gaaggctggc accccgccag gacgcccggt
    12601 tccggatacg cccacctgct cgcccacctc gcagcccacc tcgacgacgc gcggatcgac
    12661 ctcgacggcc cgctgctgga cgcctgccac gccccgcccg aggaccccga aatcctggcc
    12721 gcctggccgg cggactgcct gctgcgcccg ctcgacgccg aggggccggt cgccgtcctg
    12781 gagacggtct ccccggccgg cgtgctcgac gcccggttcg ccgaggcgct gcacgccctg
    12841 cacgccggtc ggggcggcta cccccaaccg gccgcctacc gggccttcct cgccgccctc
    12901 gaacgggccg cggacgtccg cttcgtcgag gtgctggtcc ctccgttgga cgctcgcgcc
    12961 gccaacgccg tacggcgtcc cgtgctcacc gactggtcca ccggagacgc caacacggct
    13021 ctctactacg ggagttacgg tgacggtgag gcatgcggag cggtggccgc ggcgacgccc
    13081 cggccgccgg gcgggaacgc tccccgcccc gtccgccacc tacccctcga ccggctcacc
    13141 ctccgctccg acgggcgcca cctcatcgcc gaggtcgacg gggcgcgggt cttccccgtc
    13201 caccacgcca cccggaaccc cgccccgccc tacgaccggc tcacccgcct gctgatggcg
    13261 gccgcccacc cggccaccca gcacgtggtc caactgggcg gcctgatcgg ggcgttcccc
    13321 acggccgggc gggtgccccg gctgtcggtg ggcggggacc tggtcgtcag ccccgccgcg
    13381 tggcgggtgc ccgtcgcgga actgtgggag cccaaagccc gggaggccga caaggtgacc
    13441 gccctggccg tcctccggcg cacccggcag ctgccgcgct tctgcttcgc ccgcccggcg
    13501 cccggtgcca aaccggtacc ggtggacctg gcggcgctgc ccgccctgca cgtcctggaa
    13561 cgactgcggg ccgccgcgcc cgacggggcg ttgatcatcg aggaggcgct gcccgcacct
    13621 ggccgctcgc cggtgcgcga cgccgtccac ggtggtgccc ccgtcgccgc ccaggtacag
    13681 ctgcggacgc cgtacgacgc ccaccccgag gagttggcgg cccgcgccgc cgcggccctg
    13741 cggcactgga ccgcaccgcc cccgcctcga ccgaggcccc agaccacccc ggacgcccct
    13801 ccagagggac ggcccccggg gcggaaccgc acaccgagaa aaggagggca gtcatgccca
    13861 caaccatcga actgaccgac ctcgacaacc tcatcggcga tctggacgcc cggatcaccg
    13921 agtccgaact acccagcgcc gaggcgtaca ccggcggctg ctccggcgtc tgcacggtca
    13981 tcgtctgcga cacggtgctc ttctgttccg gggtcgtctg ctgaccggag gatccacccg
    14041 ccgcggatga gcaccgcggc gcgacggacc gtcaacgcat ctcgcagcag acgaggttga
    14101 acgagccgtc cggcatcccg ccggacggct ccctgccctg gaggacgccg cacccatgcc
    14161 cctgcactcc cgcaccggac acaccgccgc cgtgcacccg cgcccctcac ccgctcggga
    14221 ggcccggtgg cgggcccacg ccctccagga cgcggtgctg ctcctcgacc ggtacgtcga
    14281 gcgggccggc accggccaga caccgggcgc cggcggccac ccctcggacc cgggcgtccc
    14341 ggtcctcgcc cgactggtcg ccgaccgcgg cgaccccgtc gccacggccg cggcgagccg
    14401 cgccaccgcc gtgtgggccc gcaccgccgg acgcggggcg ggccacccgg gcctctacga
    14461 cggcgggctc gccggaaccc tcgtcgggct gcgccaggca gccaccctcc acccggccct
    14521 gcaccaggtc gccgaccgcc tcgccgaccg gctccccgca cgcatcctgg ccggcgccgc
    14581 acgcaccacc cccggagcgg tcaccttccg ggactacgac ctgatcctcg gccccgccgg
    14641 caccctcctc gccctgagct ccgccgcccc tgagcggcac cgcgtgctcg tccgcctcgg
    14701 ccggtgcctg gccgcgctct gcgccgccga cgggctcgac ggactgcgca cccactatcc
    14761 ggaacatccg caactgggct ggctggacgg gcggatcaac acgggcacgg gccacggcgt
    14821 cgccggcgtc ctgaccgcac tcgccgtggc cgcccggcag gcggaggagg gcgacgcgag
    14881 cgcggccccg gaactcgccg cggccctgcg gcggacgagc cgttggctgc gaggccagtc
    14941 gttcgtcgac gcgcggggca ttcgctcctg ggacggcgcg gggccggaag ccgccccgcc
    15001 cggcggggcc cgccgtcgac aggcgtggtg ctacggagcc cccggcgtca gctgggcgct
    15061 gtgggacgcc ggggacaccc tccgggaccc cgcggtccgg gacttcgccg gcgccgcctt
    15121 cgacaccctc gccgccggct acgacgagga cttccacctc ttcggcgacc acctcggcga
    15181 ccgcctcggc ctctgccacg gcgccgccgg ggtgctggcc gtcgccgacg cgctgcaccg
    15241 gcacgctcgg ctgccgtcgg ccgccgcact gcgggcccgt ctcctggcgc gcctcgatgc
    15301 ccaccgggcc ggcacccgcg cgctgggaga ggaacggatg ggcctgctgg gaggcgccgg
    15361 cggcaccctg agcgccgtgc tcaccgccac cggcggcgcc cgcgactggc tgccctgcct
    15421 gggcctgcgc tgaccccccg ccgtaaccag cgatgtgagt ggccgttaac ccatccatga
    15481 gcgatatgaa cgaccgcctc ctcagcctcg tcgacggtgt ggtggatctg gacgaggaac
    15541 gactgcccct gctcaccttg cgcgaggcac aggccgcgat cgagctgctg cgcctgctgg
    15601 cggcgggcga cggcgaaggg tcgcacgccg cccggcactt ggcacggaac ctcggacgcc
    15661 ggatgccctc cgaacactga ccgcggccgg tgccggcggg gcgaggggcg gacgggaggc
    15721 gaaaatccac gatcgatagg attttcgcca tggcgaaaca cctgttattc gtggccctgc
    15781 tcggtcacgg gcacatcaac cccacacttc cgctggtcga ggaactcgtc cgccgcggcc
    15841 accgcgtgga ctacgccacc agcgcggaac acgccgaggc ggtcaccagg tccggggccc
    15901 actgggtgga gctgccgccg ctcccgccga tcgaccggcc caccgaattc ggcccggaga
    15961 ccttcggccg cttcatgcgc cacctcttcg ccggaatgcg tacggcctac ccggtgctcc
    16021 gggaccactg cgccaccacg ccggtggacg cgatctgcta cgacgccatg aactggtccg
    16081 cccgggtgct cgccgaggaa ctggacctgc cggccgtccg actgatcccc aacttcgcct
    16141 cgaacgagac gtattcgctc ttcgcccagt tcatgaccgg aaccgacggg gtgcacccgg
    16201 tcacggcggc catcggcgcc gactgcgcgc agttcgccgc ggaacacggt gtcgcgctcg
    16261 acccggcgca cctgctggac gccaccgaga aactcaacct ggtgttcata ccgagggagt
    16321 tccagcccgc cggcgactcc ttcgacgagc ggttccactt cataggtccc tcgctcggca
    16381 gccgcgcgga cgaaccgtgg tcgccgccgg accccgaggc cccggtgctg ttcgtctcgt
    16441 tgggcacggt cttcaacgac cgccccgagt tctaccgcac ctgcatcgac gccttcgccg
    16501 acgagcccta ccacgtggcg atgtcggtgg gcgggctgga cccggccgcc ctggggccga
    16561 tcccggcgtc gttcgacgtc cgtgcgcggt tcccgcagcc ggcagtgctc cagcgggcca
    16621 ccgccttcgt ctcgcacacc ggcatgaact ccacgatgga ggccctgtac tacggcgtcg
    16681 gcctgatcgc cgtcccgcag atgcccgaac aggccgccaa cgccggacgg gtgcaggagc
    16741 tcgggctcgg cgagcagctc gacgcccgca cggtgaccgc ggaggcgctg cgggccgcgg
    16801 tggccagggt cgcgtccgac gacgcggtcc gcgccaacct cgacgggatg cgcaaggtcg
    16861 tccgggagag cggcggcgcc gtacgcggcg tcgaggtgat cgaggagtac ctgcgctgag
    16921 cggccggccg gtccccccca cggcggtggg gcggaccggc caccgccttc aggagccggg
    16981 cgacggggcc ggcgcgccgt ccttgagcat gccggtgcgc agccggctca acgtgcggtt
    17041 gagcagccgg gagacgtgca tctgcgacac gccgagctcg gccccgatct gcgactgggt
    17101 catctcctga ccgaagcgga gctcgatgat gcgccgttcg cgggcgtcga gttgccgcag
    17161 cagcggcgcg agggtgtgga ggtcctcgac ggtctccagg gccgggtcgt gggcgcccag
    17221 cacctccgtc agcgcgcgcc gctggtcacc cgggtcgggg tcggccgggg tgtccaggga
    17281 gtccgcggaa tagccgttgg ccgcgacgag tccctcgatc acctcctcct ccgacagctt
    17341 caggtgcgcc gcgagctccg cgacggtggg gtcgcggtcg agcgcggcgt gcaactgctc
    17401 cttggccttg gcgagttcgg tgcgcaactc ctgcaaccgg cgcggcacgt gcacggccca
    17461 gccggtgtcc cggaagaacc gcttgatctc gccgaggatg tacgggacgg cgaaggtgga
    17521 gaactccacc tcgcgggaga ggtcgaagcg gtcgatcgct ttgatcaggc cgatggtgcc
    17581 gacctggacg atgtcctcca tgtcgtcgcc gcgatggcgg tagcgacggg cgacgtagcg
    17641 caccatcgac atgttcatct cgatcagcgt gttccgtgcg tactggtatg cgtgggtgcc
    17701 ctcttcgagc tcctgcagcc ggtcgaagaa ctgcttggag agcgcgcggg cgtcccgcgg
    17761 cgccacggca cgcggccgcc tgacctccgg gagaccgtcg tcgcgtgccg tggtctgcgc
    17821 cggatccgcg gtgtcgttca cgacgatggt catcacgtct ccctccgtgc ccgacccccg
    17881 cgggcaccct tgccggcgct taccccgtcc gtgccgaggc atgcgtgccg cggaggaatc
    17941 cggccagcgc gggggtcggt cgccgcgagc gcaggtcggg ggcgtcagga aaacgacgtc
    18001 gggcccggca gggacgcggt ggccagcgcg aacagcgcct cctcgggggt gtcctggacc
    18061 ggcatgctga cactgatccc cgtcaggtcg agcagtcgcc ggacgaccgg ggaagcggcg
    18121 gccagttgca cgcttccgcc caccttcttg gtgtcgttgt gcaccctgat gatgacgccc
    18181 agccccgagg aatccatgaa cggcacatcc cgcaggtcga gcacgagatg gcgtcggccg
    18241 tgggcgagtt ggttggcgag ctggtggtgc agggcggttc cggtggcggt gtcgagctca
    18301 ccgcacacgg ccgccaccgc cgtccgctcg tcgacgacgg tgacttccac gctcagcaga
    18361 tcggcacgca acatgtgtcg gctcccttgt cgtggatcta ccccgtggtg gaccgacggt
    18421 gcgccgggcg gctcgtgccg ccggaaggcg caggtcaccg gggaagaccc ggtcgtgcag
    18481 tccgtccgtg ccgggcccga gtggagcggt tttggcagac cgcgccaggc gttggccggc
    18541 tccgggcgga cctcgttctt gatccgtgac gaggggtcgc ctgccccgat gatccccggc
    18601 tattcctggt gttcgcgaaa tgcccggacg cgcgccccgg cgctgctcac cgcaggcgca
    18661 gcgtgacgtg gatgaccttg ccgaacgccg tcgaggtgat cacgacggac gtggcgagcc
    18721 ggccgaccag cgaccagccg tagccgccga tccggccgtc acgggtgtcg gacggcacga
    18781 acgggtggac cgggctggcg tcttcgacgg tcacttcgag ccgatcgccg ctgatgcggg
    18841 aggtgaagcc ggtgactcca ccggcgtgcc gcagggcgtt ggtgaccagt tccgaggtga
    18901 tcaacaaggc gtcggccacc acgacgtcgt cgacctgccg gtggccggtg cgcagcaggg
    18961 cgagcacgcg gtcacgcgct tcgcctgagg tagcgggcag ttccgcggtg agagccaccg
    19021 ttcacctcct tggtggtaca gggtccggcc tcgggtgtgc gtctacccgc cgtactgcga
    19081 ttcgtgcatc agagggtcac tctgccacac ggccgggtca cgcccgggcc gttcccgctt
    19141 cacgacgacg gtggagtgga ggcggcggca gcgggcgggg ccgtcaggtg gtccaacgtg
    19201 ccggtcacgg ccagtagccg gtcgagtgcg ggtggacgct cctccaggtg caacgacacc
    19261 cccagcgcgg tggtgcgacg gtggaccatc agcagcgcgg acaggcccat gcagtcgcgc
    19321 agcaccagcc cgccgcagtc cacgcgcagg gcccgcaggc cggtgtgggc ggcgaggtgc
    19381 tcggtcacgg cgtcctggaa ctcggcggcg ctgtcgacat cgagttcgcc gcgcaccgtg
    19441 atccgcagca cgtcgggacc gacggccgtc gaggagaggt ggagtatccg ggcgggggac
    19501 ggatcggtca tgcgggctgt ccggggtcga gccgttcggt ggcgggcggc ccggaagcac
    19561 gcagggcacg ggagagggcc tgccgactgc gggtgatcag tcccacggcc cgggggaagt
    19621 cccgcagcgc gcgctccagc aggtccaggg cgggcagcag cgattccggg ggcaccgctc
    19681 gggcgcgcag gacgtccgcc gtccacgcca ggaaaccgct gaacagctcg gtgtcgtcgg
    19741 tgtagagggc ggcggtgagg aattccacga gatgcgcgac gtcctgcgcg gtgtggtccc
    19801 gttgtccgtc gtcgtagtcc agcagcgcgg ggaaacgggt ctccagaccg gccagcacct
    19861 cccgcaccaa ctgtcgggag cccctggcga ccagcgtgta ttcctggtcc gccaggtgcg
    19921 gcagatcgtc gatcgcctgg tggtccgcct tccggcgggt cagggggcgc tgcagccgct
    19981 ccgccgcctg gcgggcgtcc ggcgcccagg catcggcacc caactgccgt gcgtgacggc
    20041 cgtcactccc gaaggccgcc ccgcccacca gcaccggcac cccggtggcc tggcaggcgg
    20101 tgatcgtggc gtgcgcggcg ggcagccggg tgaccaggga actcgacagc gccaccaggt
    20161 ccgggttggt gaggtggagg tgggcgatca ggtgcggagc cgggacctgc gcgccgaggt
    20221 agtccacccg ccagccgcgc agccggagca cctcggccaa cagccgggcc ggcaacgcgt
    20281 gccattcgcc gtccacgcag gccacggtga tccggccgcg cgccggcggt acgggcggga
    20341 tgtccgggtg ctgcgcgagc agggcgatga cctgctcgtt gatcgcggtg gccgcgtgct
    20401 cctgcgccac gctcagccgg ttcgccgccc actccacgcc gaccctccgc tgaacgccgc
    20461 cgatgacgtc cagcagcagg gtctccggcg gcacgccgtc cgtcagtgcg tccaggacgc
    20521 cggtgccggc ggcgtgctcg tcaccggcac ggaccgcctc ccacaaccgg tttgcacagg
    20581 aagggacttg gtccccggcg gtgagtgggg cagggggcgc cgaggacgtc gtcatgcacc
    20641 gtgtccctcc gtcggggtgc cgcccggcgc ccggcgcgaa gagccccgcg gcgcggtgac
    20701 ggtcaccacg gccatgtcgt cgtgcttgtt gactccgacc cactccgtcg ccagcatctg
    20761 gacgtgctcc gccactgcct cggcgggcat ccccgcgcag tgggcgagcg cccgtcgcag
    20821 ccgtgcgtcg ccgaagagtt cgtcgcccag cgggccgccc ttggactcgg tgatgccgtc
    20881 ggtgaagagc accagggact cgccgggggc gagggtgagc ggggcggtca ccgcatcgat
    20941 ctccggcagc acgccgacga ggttgccgtg ggtctcgacc tccgccaccc ggccgtccgc
    21001 ccggacgacc aacggagcgg ggtgcccggc gcacgtcacc cgcagctcca cccggtccgc
    21061 ccggcggcgt gcggaggcca cgacgagcgt cgcgaaccgg gtgtggtggg agctgagcag
    21121 tgcgccgttg agcagccgga gcatccgcac gtggtccccg gacagcggca gcagcgcgtg
    21181 cagggtgttg cggatcttgc cggtgagcac cgcggcgtcc agccccttgc cgcagacgtc
    21241 gcccagcacc accagcgact cgtcctgtgg cgccgcggcc ggatggatgt cgtagaagtc
    21301 gccgccgacg cgctcgccgt ccttggccgc gcggtagcgg gccgcgaact ccacgccgcc
    21361 gacctggccg acgcgcggcg gcagcagctc gcgcatcaac gtctcggtga tctgcgcctg
    21421 ttccgcgtag agccgggccg cggacatcgc cgccccggcc cgggccgcga agagccgcgc
    21481 gaaggactcc tcgctctcgc tgaacgcggc gtggtgggcc cgccgcagca gcaccagcgc
    21541 accggccggc acgccgtggc cgggcagcgg ggtgacgacc atcgccccca cggggccgaa
    21601 gtcctcgggc accagccact ccggggccgc cgcaggatcg atccagcggg acggcgccgg
    21661 cgggaacccg cgcagcgcct cggcgaggcc gggcaccgac tccggtgcga caccggtcag
    21721 ttggcggatg tgtgccccgg tgccgtcggc ggacaccacc gacagcaccc ggccgcgcgg
    21781 gggagcgatg acgacggccg cgtccgcgag gtgggcggcc gccaaccggc cggccacctc
    21841 catgcaccgg tccaagttca gcgacgacag cagttcgttg gaggccctgg ccaggaacgc
    21901 ggtccggttg cgttcctgga gcagtcggcg ttcggccagc cgggcgtcgg tgtcgtcggt
    21961 cagccaccac accacctcgc cctcgggcag gcgggtggca tgggcctcga agctgcggcc
    22021 ggccacctcg ccccgtggcg gcggcgcatg cggtgcgggt gccgcggaca gccggtcgtg
    22081 ggccagcagg agccagccgg gcagcacctc gcgcagtgcg ctgccctcga cggcgtcggg
    22141 caccagcagg ccgaacgcct cgttggcccg acgcaccgtt cccacggggt cggccacgag
    22201 gaccgggtag ggcgcagcgt gcagcgccgc gtcgctccag gcgttgtcgg ccgagcgttt
    22261 tgcggagttc accacgtgtc gggccccggg gccgtccgga agccgctcac ctttcctggt
    22321 cgtgccggcg ggggactgcg gcccaccatt ccaccgcctg gcttccgcgc gcaatccgcc
    22381 cccggccaat tcctccgcgc cgctgcgtgt cccgatcatc cggtggctct gtcgcccgcc
    22441 gcgggggccg gccgacggtc cccggcgcgg gccggacgga cgcgtcacgt gcacgctcat
    22501 ttcggccgga cccgtgatct ccgggagtgc ttcgaccacc atccgtgaca tcctgtcacc
    22561 catgcacgca cccacaccgg ccgtggtcac ccacgcagtt gaggatcagg tgttcgtcat
    22621 ccgcgtcacc ggctccctcg accacgagag tgccgctctc ctggaagagg cgtgtgcgtt
    22681 ggcggagtcg cacgcggccc gaaggacggt ggtggacctc tccctcaccg acttcgcgga
    22741 ctccaccgtc ctccacgtcc tgctcggcgc gcaacgggcc caccaccgcc ggcaacgcag
    22801 gctcctggtg gccggcccct tccagccggt ggtgcgccgc cttttcgagg tcacgggcac
    22861 gaccgactac ttcaccctcg tcgacaacgt gccgaccgcc gtgcaggagt gaccccgctc
    22921 gggccgccgg ggcccgcgga cgccggcggg cgcgcccggt ccgaccaggc cctcactgat
    22981 ccgcgcaggc atccaggcgc cgggccagtg cacgcacgag gtcgcgcagt tccgcggggt
    23041 gctcgatgac gaacgggcgg tccagtgcgg ccagtacggg cggaatccag tccagccgct
    23101 cggcgcgcat ccggacccgc acccaaccgt ccaggtccgc ttcgggcgtc ccgtcgggtt
    23161 cgccgtcgcg ttcggccgga tccgcgtcgt cggtccccgc cgcggcggcg atcggggaca
    23221 ccgtcgcgag gtcggccggg aggtgcctgc ggacgtgcgg cacgtcggca cggacgcgca
    23281 gggacacctc gtgggcccag ggcgtccgcg cgaggccggt cagtacccgt gtcaccggat
    23341 cgaacgtcgc cgggacgacg aacgagccgg agcgcacgct cagggcggag atccggtcca
    23401 gccggaaggt ccgcacgccc ccgtcgccgg cggtggggtc cgcgccggcc aggtaccagc
    23461 gcccggcgtg cgccacgagg ccgtagggca ggacggtgcg gtcggtgcgg cggcccttgc
    23521 gatcggtgta ggtgagcgcc accggccgtt gctggtgcgt ggcctccgcc aggccgagca
    23581 gcacggccgt ctccggagcg gcgccggggt gcggccgtgc ggtgacgtcg gccgtctcca
    23641 acagcgctgc caggcgccgc gccaggggct tgggcagcac gcgccgcagt ttcgccgcgg
    23701 cgctctcgct cgccgcggcc gaggtggtga ccagtcctgc cgactgtgcg gccaggaggc
    23761 cgagcacgac ggccagcgcc tcctcgtcgg tgagcatcag tggcggcatc cggtagccgg
    23821 gggcgagtcg gtagccgccg taccggccgc ggaccgcgtc gacgggcacg tcgagatcca
    23881 acaggtggcc cacgtagcgg cggacggtgc gttcgtcgac cgccaggcga gcggccaggt
    23941 cggggacggt gtggatgccg ccgccctgga ggatctccag cagggcgagc acccgagtgg
    24001 tcgtagtggt caccggacaa gtctgccgcc cataccgggc ggatcctgtc cgctattggt
    24061 tctaacgttc agacgtccgc tcgccgcatc cggcgtcgcc tctccctggg agccgttcgt
    24121 gaacctcgtt tctctccgca tgatcaccca cgacgtggcc cgtctcgtcg cgttctacga
    24181 aggggtcacc gcggtccccg cgacgtggtc cacccctgaa ttcgccgagt tggtgacgga
    24241 ggcgtgcacg ctggcgatcg ccagcgaccg caccgtggcg ctgttcggcg ccgactccgc
    24301 ccgaccggcc gccaaccgca ccgtgatcac cgaattccgc gtcgccgacg tcgatgccgc
    24361 gtacgcgcgc ctgacgtcgc tggactgcgt gttcgtccag cggccgacga ccatgccgtg
    24421 gggcaaccgc tccctcctct tccgggaccc ggacgggaat ctgatcaact tcttcacgcc
    24481 cgtcaccccc gaggccgtgc gacggcagga gcggtagcgg cccgtccggg acagcggcgc
    24541 gctcgggctc cgtccgtctc gtgggccgtc cgtgccggaa cgtcaccgcc ggcgctgggg
    24601 cgcggtcaag ttcctttgcc gaacagtcgg ttgaggtgct ggtcgacggc ggtcagggcc
    24661 tcttggggct cgatcacgcc cagttcgacg agcggggtca agccggtgag cgccaggagc
    24721 aggttggtct cggtcgccgg gtcgcggtcg gggctgaggt ggccgtcggt gacggcctgg
    24781 cggacgatcc gctcgacgag gtcgcggccg tgcgccaacc cgtcgcgtgc gcgggtgcgg
    24841 atgttcgcgt cgtgcagtgc ctccaggacg taggcggcgc tcatccggct cgtcgtgcgt
    24901 gcgtcgggac ggagggggag catctccacg agcatcacgc ggagcaggtc gcgggggtgc
    24961 ggtgggtcgc cgagtgcgct gacgccttcg gcgacgcgca gcgacgtctg tgcggacgcg
    25021 aagtccatgg cgaagaccac catctcttcc cgggtggcga agtagtgctg caccgcgccg
    25081 tgggagatgc ccgcttcctg ggccacctcg cggacgctcg cctgcgcgat gccgcgttct
    25141 tccactacgc gccacagcgc tcgggcgatg gtctcgcggc gttcgcggtg atccacctgc
    25201 ttgggcatgg tcggcctccc cttattccat acggttgaca tattacagct gaccggtaaa
    25261 agctgggagt ccgatcgcgg gggaaggatg tggcatgtcc gaacgaccga gagcacggac
    25321 tgcggaggga ctcgtcgaag ggtgctggcg gggagggcac gcggtcttcc gcggcatccc
    25381 ctacgcgcag ccgccggtcg ggccgctgcg cttccaggcg cccgccccgg tcg
//
