LOCUS       NZ_CP119144            10411 bp    DNA     linear   CON 22-NOV-2023
DEFINITION  Streptomyces noursei strain C27 chromosome, complete genome.
ACCESSION   NZ_CP119144
VERSION     NZ_CP119144.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces noursei
  ORGANISM  Streptomyces noursei
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 9627936)
  AUTHORS   Go,B. and Lu,Y.
  TITLE     Control effect and mechanism of Streptomyces NK27 against gray mold
            of grape
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 9627936)
  AUTHORS   Go,B. and Lu,Y.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-FEB-2023) State Key Laboratory for Biology of Plant
            Diseases and Insect Pests, Institute of Plant Protection, Chinese
            Academy of Agricultural Sciences, Yuanmingyuan, Beijing 100193,
            China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 01-OCT-2021
            Assembly Method                   :: ABySS v. 2.3
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 98x
            Sequencing Technology             :: Complete Genomics
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 11/22/2023 14:00:30
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,442
            CDSs (total)                      :: 8,348
            Genes (coding)                    :: 8,203
            CDSs (with protein)               :: 8,203
            Genes (RNA)                       :: 94
            rRNAs                             :: 7, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 145
            CDSs (without protein)            :: 145
            Pseudo Genes (ambiguous residues) :: 0 of 145
            Pseudo Genes (frameshifted)       :: 46 of 145
            Pseudo Genes (incomplete)         :: 121 of 145
            Pseudo Genes (internal stop)      :: 12 of 145
            Pseudo Genes (multiple problems)  :: 30 of 145
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 16:17:19
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 6638430
            Orig. end                         :: 6648841
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP119144.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..10411
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="ectoine"
                     /region_number="25"
                     /rules="ectoine_synt"
                     /tool="antismash"
     cand_cluster    1..10411
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="ectoine_synt"
                     /kind="single"
                     /product="ectoine"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10411
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:5411](-)"
                     /cutoff="20000"
                     /detection_rule="ectoine_synt"
                     /neighbourhood="5000"
                     /product="ectoine"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..5411)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="ectoine_synt"
                     /neighbourhood="5000"
                     /product="ectoine"
                     /protocluster_number="1"
     gene            complement(1..684)
                     /locus_tag="P0D74_RS28960"
     CDS             complement(1..684)
                     /EC_number="2.1.-.-"
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: oMT (37-140). E-value: 2.9e-07. Score:
                     20.8. Matches aSDomain: nrpspksdomains_P0D74_RS28960_oMT.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018091833.1"
                     /locus_tag="P0D74_RS28960"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_275465209.1"
                     /transl_table=11
                     /translation="MGTPAPHGTDGFWETTGAAKTFTHPIDPALLAEFVPRTARVLDYG
                     CGYGRLTAELVGLGYGAVRGVDRSAALIARGRQAHPGLALLRWSGFPLPFADGSFDAAL
                     LFAVLTCVPDDADQRAIVGELARLVRPGGVLYVSDVPLQDDPFNRARYERFAARFGTYG
                     VFETPDGGVFRHHPPPWLRGLLRAAGFAVLRECRTVVPTLDGRTAERLQLMTRREPAVA
                     GPAPG"
     aSDomain        complement(265..573)
                     /aSDomain="MT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_P0D74_RS28960_oMT.1"
                     /domain_subtypes="oMT"
                     /evalue="2.90E-07"
                     /label="P0D74_RS28960_oMT.1"
                     /locus_tag="P0D74_RS28960"
                     /protein_end="140"
                     /protein_start="37"
                     /score="20.8"
                     /tool="antismash"
                     /translation="TARVLDYGCGYGRLTAELVGLGYGAVRGVDRSAALIARGRQAHPG
                     LALLRWSGFPLPFADGSFDAALLFAVLTCVPDDADQRAIVGELARLVRPGGVLYVSDV"
     gene            821..1525
                     /locus_tag="P0D74_RS28965"
     CDS             821..1525
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007450493.1"
                     /locus_tag="P0D74_RS28965"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DsbA family oxidoreductase"
                     /protein_id="WP_275465210.1"
                     /transl_table=11
                     /translation="MRVEIWSDIACPWCYIGKARFEAGLAAFAHRADVEVVHRSFELDR
                     DAPPATDVPILDMLASKYGVSRAQAEEMEARVAEAAAGEGLGYRSDRIHGNTFDLHRLL
                     HLAKAHGVQDALLTALYHANFAEARQLGDPAVLTGIAVEAGLPADEAARVLADPDAYAA
                     EVRADERTAAELGATGVPFFVIDRRYGISGAQPVDVFHQALERAHADSAVQVLAAGDAD
                     VCGDGGCAVPGA"
     gene            1599..2672
                     /locus_tag="P0D74_RS28970"
     CDS             1599..2672
                     /NRPS_PKS="Domain: Aminotran_5 (16-350). E-value: 7.5e-21.
                     Score: 66.4. Matches aSDomain:
                     nrpspksdomains_P0D74_RS28970_Aminotran_5.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139: aminotransferase class V"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016574048.1"
                     /locus_tag="P0D74_RS28970"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="aminotransferase class V-fold PLP-dependent
                     enzyme"
                     /protein_id="WP_275465211.1"
                     /sec_met_domain="Aminotran_5 (E-value: 9.7e-13, bitscore:
                     46.7, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQRHTALGGDEFAPETVYLNSASSGLLPARTAAAVRDALAESASH
                     GTMGRDYFGTADRARGAFARLMGVPAERVAVGSSVAVRSAFVAASLPAGSEVLVTEGDF
                     SSLVNPLMAHGGCTVRAVPREALAEAVRPRTALVALSAVHPQDGRIADLAAVRDAARAH
                     GALTYVDVTQAAGWLPVPLADFDYAVCGAYKWLLCPKGTTFTVFGGERGELGGPGWPVP
                     AHAGWVAGEDPGESNYGPIDRPAPTARRYDEPHANYAYVGAEHSLGLLAEIGLATIHAH
                     DVALAEQYRAGLVAAGFTPRAAPGSAIVSTPGLADAEPRLAAAGVRVAVRGGLLRAAFH
                     LYNSRADVDRALELLVP"
     aSDomain        1647..2648
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_P0D74_RS28970_Aminotran_5.1"
                     /evalue="7.50E-21"
                     /label="P0D74_RS28970_Aminotran_5.1"
                     /locus_tag="P0D74_RS28970"
                     /protein_end="350"
                     /protein_start="16"
                     /score="66.4"
                     /tool="antismash"
                     /translation="VYLNSASSGLLPARTAAAVRDALAESASHGTMGRDYFGTADRARG
                     AFARLMGVPAERVAVGSSVAVRSAFVAASLPAGSEVLVTEGDFSSLVNPLMAHGGCTVR
                     AVPREALAEAVRPRTALVALSAVHPQDGRIADLAAVRDAARAHGALTYVDVTQAAGWLP
                     VPLADFDYAVCGAYKWLLCPKGTTFTVFGGERGELGGPGWPVPAHAGWVAGEDPGESNY
                     GPIDRPAPTARRYDEPHANYAYVGAEHSLGLLAEIGLATIHAHDVALAEQYRAGLVAAG
                     FTPRAAPGSAIVSTPGLADAEPRLAAAGVRVAVRGGLLRAAFHLYNSRADVDR"
     gene            2815..3885
                     /locus_tag="P0D74_RS28975"
     CDS             2815..3885
                     /GO_function="GO:0010181 - FMN binding [Evidence IEA]"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1217: NADH:flavin oxidoreductase/NADH oxidase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016574047.1"
                     /locus_tag="P0D74_RS28975"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="alkene reductase"
                     /protein_id="WP_275465212.1"
                     /transl_table=11
                     /translation="MTTAFDPIELAGIPLANRIVMAPMTRNRATEAGVPTPSMVTYYTQ
                     RASAGLIVTEATQTEVVGRGYPLTPGLHTAEQVAGWRRVTDSVHAAGGRIFAQLWHGGR
                     IGHPVLLPDGLEPVGPSPVRAAGQGFTQNGPTDFVTPRELTDEEIRATVDGFAAAARNA
                     IEAGFDGVEIHGANGYLVHQFLAPNANLRTDAWGGSDAARARFAIEVVKAVAEAVGAHR
                     TGLRLSPGNPFNDIAEPEPEATYTALLDAVSPLGLAYLHTCDVHDLQLLARLRKRFDGP
                     FLLNPATVGRPTGPEELPLVEQGDADLLAYGALFIANPDLPRRLAAGGPFNAPERASFY
                     GGDDHGYLDYPALDHN"
     gene            complement(4018..4920)
                     /gene="thpD"
                     /locus_tag="P0D74_RS28980"
     CDS             complement(4018..4920)
                     /EC_number="1.14.11.55"
                     /codon_start=1
                     /gene="thpD"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PhyH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007828636.1"
                     /locus_tag="P0D74_RS28980"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ectoine hydroxylase"
                     /protein_id="WP_275465213.1"
                     /sec_met_domain="PhyH (E-value: 4e-35, bitscore: 120.9,
                     seeds: 39, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTAPERTADLYPTRGTSEVITPRQDPVVWSRPGAEGPFAASELS
                     DFDRDGFFAMPELLTAGEVAVYSAELDRLVNDPATRADPRSIVEPQTQDVRSVFEVHRI
                     SDVFARLVSDPRVVGRARQILGSDVYVHQSRINVKPGFGASGFYWHSDFETWHAEDGLP
                     NMRTVSVSIALTENYDTNGGLMIMPGSHRHFVGCEGATPKDNYKKSLQMQDAGTPSDGT
                     LTTLADRHGIRLFTGKAGSATWFDCNAMHGSGDNITPYPRSNVFIVFNSMENTAVEPFA
                     APVRRPEYIGARAPFAPVK"
     gene            complement(5001..5411)
                     /locus_tag="P0D74_RS28985"
     CDS             complement(5001..5411)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ectoine: ectoine_synt"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003986837.1"
                     /locus_tag="P0D74_RS28985"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ectoine synthase"
                     /protein_id="WP_016577186.1"
                     /sec_met_domain="ectoine_synt (E-value: 2.8e-51, bitscore:
                     171.6, seeds: 10, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIVRSFKDIEGTDRHVKAKSGTWESKRIVLAKERVGFSLHETVLY
                     AGTETSMWYANHIEAVVCTEGVAELTNDETGEKHLITPGVMYLLNGHEKHTMRIKEDFR
                     CLCVFNPPVTGREDHDENGVYPLLTEPEPEAS"
     gene            complement(5465..6733)
                     /gene="ectB"
                     /locus_tag="P0D74_RS28990"
     CDS             complement(5465..6733)
                     /EC_number="2.6.1.76"
                     /GO_function="GO:0045303 - diaminobutyrate-2-oxoglutarate
                     transaminase activity [Evidence IEA]"
                     /NRPS_PKS="Domain: Aminotran_3 (28-365). E-value: 3.4e-74.
                     Score: 241.8. Matches aSDomain:
                     nrpspksdomains_P0D74_RS28990_Aminotran_3.1"
                     /codon_start=1
                     /gene="ectB"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1013: aminotransferase class-III"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007448159.1"
                     /locus_tag="P0D74_RS28990"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="diaminobutyrate--2-oxoglutarate transaminase"
                     /protein_id="WP_275465214.1"
                     /sec_met_domain="Aminotran_3 (E-value: 1e-76, bitscore:
                     257.2, seeds: 13, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTITQPDLSVFETVESEVRSYCRGWPTVFDRAQGSRLTDEDGHTY
                     LDFFSGAGSLNYGHNNPVLKRALIDYIERDGITHGLDMSTTAKRAFLESFQNIILRPRD
                     LPYKVMFPGPTGANSVEAALKLARKVKGRESIVSFTNAFHGMSLGALAVTGNSMKRAGA
                     GIPLVHGTPMPFDNYLDGQTPDFLWFERLLEDQGSGLNKPAAVIVETVQGEGGINVARA
                     DWLRALAALCERQDMLLIVDDIQMGCGRTGAFFSFEEAGIVPDIVTVSKSISGYGLPLA
                     LTLFKPELDIWEPGEHNGTFRGNNPAFVTAAAALDTYWADGQMEKQTLGRGEIVEGHLK
                     AIVAEHPGAFAEYRGRGLVWGLECTDKELANKIAKRAFELGLLIETSGPQSEVVKLLPA
                     LTTTPEELDEGLRTLARAVRDCA"
     aSDomain        complement(5639..6649)
                     /aSDomain="Aminotran_3"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_P0D74_RS28990_Aminotran_3.1"
                     /evalue="3.40E-74"
                     /label="P0D74_RS28990_Aminotran_3.1"
                     /locus_tag="P0D74_RS28990"
                     /protein_end="365"
                     /protein_start="28"
                     /score="241.8"
                     /tool="antismash"
                     /translation="FDRAQGSRLTDEDGHTYLDFFSGAGSLNYGHNNPVLKRALIDYIE
                     RDGITHGLDMSTTAKRAFLESFQNIILRPRDLPYKVMFPGPTGANSVEAALKLARKVKG
                     RESIVSFTNAFHGMSLGALAVTGNSMKRAGAGIPLVHGTPMPFDNYLDGQTPDFLWFER
                     LLEDQGSGLNKPAAVIVETVQGEGGINVARADWLRALAALCERQDMLLIVDDIQMGCGR
                     TGAFFSFEEAGIVPDIVTVSKSISGYGLPLALTLFKPELDIWEPGEHNGTFRGNNPAFV
                     TAAAALDTYWADGQMEKQTLGRGEIVEGHLKAIVAEHPGAFAEYRGRGLVWGLECT"
     gene            complement(6801..7367)
                     /gene="ectA"
                     /locus_tag="P0D74_RS28995"
     CDS             complement(6801..7367)
                     /EC_number="2.3.1.178"
                     /GO_function="GO:0033816 - diaminobutyrate
                     acetyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0019491 - ectoine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="ectA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018536877.1"
                     /locus_tag="P0D74_RS28995"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="diaminobutyrate acetyltransferase"
                     /protein_id="WP_016577188.1"
                     /transl_table=11
                     /translation="MTAAQADHAGARSDIKEIPEGFKLDTPRVEDGAAIWRIARDSKAL
                     DLNSSYSYLLWCRDFAATSAVARDATGEPAAFVTGYLRPDRPDTLVVWQIAVDAAHRGR
                     GLAAALLDGLTARAIDELGVRSVETTITPDNDASNRLFASFAARHSVPVKREVLFDAAL
                     FPEQGHEPEVLHLIGPFETPPGSNR"
     misc_feature    7522..7537
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: medium, score: 16.52"
                     /tool="antismash"
     misc_feature    7532..7547
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: medium,
                     score: 17.62"
                     /tool="antismash"
     misc_feature    complement(7557..7571)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 16.13"
                     /tool="antismash"
     misc_feature    7807..7820
                     /note="TFBS match to RpoN, Regulator of nitrogen
                     assimilation and virulence, confidence: medium, score:
                     16.73"
                     /tool="antismash"
     gene            7910..9001
                     /locus_tag="P0D74_RS29000"
     CDS             7910..9001
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Amidohydro_1"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003960017.1"
                     /locus_tag="P0D74_RS29000"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="amidohydrolase family protein"
                     /protein_id="WP_275467741.1"
                     /sec_met_domain="Amidohydro_1 (E-value: 1.1e-17, bitscore:
                     63.2, seeds: 57, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSEGAALHLKGRVLVGPDEVRDELWVIDGRVTFERPSVARDVTTL
                     SGWVLPGLVDAHCHVGLDAHGPVDAATSEKQALTDRDAGTLLIRDAGSPSDTRWIDDRP
                     DLPRIIRAGRHIARTRRYIRNYAHEIEPADLVAYVAQEARRGDGWVKLVGDWIDRSVGD
                     LAACWPPGEVAAAIAEAHRLGARVTAHCFAEESLAPLVEAGIDCIEHATGLTEDTIPLF
                     AERQVAIVPTLVNIATFPQLADGGEAKFPRWSAHMRRLHERRYDTVRAAYDAGVPIFAG
                     TDAGGSLPHGLVADEVAELMKAGLPVEAALSATTWGARTWLGRPGLTEGAPADLVVFET
                     DPRADVRVLAAPRLVVLRGRIVG"
     gene            complement(9027..9428)
                     /locus_tag="P0D74_RS29005"
     CDS             complement(9027..9428)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016576770.1"
                     /locus_tag="P0D74_RS29005"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_275465215.1"
                     /transl_table=11
                     /translation="MTRTAPGGAPGADPSATSPPADPDQPETARIQLGDLLQAFSDPLR
                     RRIVRRLATQGEAGCGDIELPVTRATGSYHFRILRTAGWTHTRRAGRERYISLRRTDLE
                     TRFPGLVDALLRADAAERDTPAEPAAPGA"
     misc_feature    9488..9501
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 13.04"
                     /tool="antismash"
     gene            9579..9992
                     /locus_tag="P0D74_RS29010"
     CDS             9579..9992
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018536880.1"
                     /locus_tag="P0D74_RS29010"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_275465216.1"
                     /transl_table=11
                     /translation="MTTADPAPPSAPAAAPTEDPSSAGPLRTLFCIGVTQDFFAADDDR
                     RAAVAAAIPPAFDRLGARFGVTVLGTLDDDQLMVGATTAWPWTSYVLADVPDLDTVAAV
                     CGIVRDTPVGDGRLWRYLRIEARVGRPLFFATA"
     misc_feature    10298..10313
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 21.39"
                     /tool="antismash"
ORIGIN
        1 tcaccctggc gctggccccg ccaccgccgg ctcccgccgc gtcatgagct ggagccgctc
       61 ggcggtgcgg ccgtccagcg tcggcaccac cgtgcggcac tcccgcagca ccgcgaaccc
      121 ggccgcccgc agcagccccc gcagccacgg gggcggatgg tgccggaaca ccccgccgtc
      181 cggcgtctcg aacacgccgt acgtcccgaa ccgcgccgcg aaccgctcgt agcgcgcgcg
      241 gttgaacggg tcgtcctgca acggcacgtc actcacgtac agcaccccgc ccggccgcac
      301 cagccgcgcc agctccccga cgatcgcccg ctgatcggcg tcgtcgggga cgcaggtgag
      361 caccgcgaac agcagcgccg cgtcgaagct gccgtccgcg aacggcagcg ggaaccccga
      421 ccaccgcagc agcgccagcc ccggatgcgc ctgccgcccc cgggcgatca gcgccgccga
      481 ccggtccacc ccgcgcaccg ccccgtaccc cagccccacc agctccgcgg tgagccgccc
      541 gtacccgcag ccgtagtcca gcacccgcgc ggtgcgcggc acgaactccg ccagcagcgc
      601 gggatcgatc gggtgggtga aggtcttggc ggccccggtc gtctcccaga acccgtcggt
      661 gccgtgcggt gctggcgtgc ccataccggg acggtaccgc cgagggcacc gtgagctccc
      721 gcgcgccgcc cacctgcgga ataaccgcgc ccgccgccgc gttgcaccgc tccgtacccc
      781 gaccggtcgc cgaccggtcc acccgaggaa agtcaccccc atgcgcgtcg aaatctggtc
      841 ggacatcgcc tgcccctggt gctacatcgg caaggcccgg ttcgaggccg gcctggcggc
      901 cttcgcccac cgggcggacg tcgaggtcgt ccaccgttcc ttcgagctgg accgggacgc
      961 cccgcccgcc accgacgtgc cgatcctcga catgctggcg tcgaagtacg gcgtcagccg
     1021 ggcccaggcc gaggagatgg aggcccgggt cgccgaggcc gccgccggtg aggggctcgg
     1081 ctaccgctcg gaccgcatcc acggcaacac cttcgacctg caccgcctgc tccacctggc
     1141 caaggcccac ggagtgcagg acgccctgct caccgccctg taccacgcca acttcgccga
     1201 ggcccgacag ctcggcgacc cggcggtgct gaccgggatc gcggtcgagg ccggcctgcc
     1261 cgccgacgag gccgcccggg tcctcgccga tccggacgcc tacgccgccg aggtccgcgc
     1321 cgacgagcgc accgccgccg agctgggcgc caccggcgtc cccttcttcg tcatcgaccg
     1381 ccgttacggc atctcgggcg cccagccggt ggacgtcttc caccaggcac tggagcgggc
     1441 gcacgccgac tccgccgtcc aggtgctggc cgccggcgac gcggacgtct gcggggacgg
     1501 gggctgtgcc gttccggggg cgtgagccgg ccggaaccgc tggggcgggt ccggcgcccc
     1561 cgtggacgcc ggacccgtta ccgaccagag tgggggccat gcagcgacac acggcactgg
     1621 gcggggacga gttcgcgccc gagacggtct acctgaactc ggcgtcgagc gggctgctgc
     1681 ccgcgcggac cgccgccgcg gtgcgggacg cgctggcgga gtcggcgtcg cacgggacga
     1741 tggggcgcga ctacttcggg acggcggacc gggcgcgcgg ggcgttcgcg cggctgatgg
     1801 gggtgccggc ggagcgggtg gcggtgggca gttcggtcgc ggtccgctcg gcgttcgtcg
     1861 ccgcgtcgct gccggccggc agcgaagtgc tggtcaccga gggggacttc agctcgttgg
     1921 tgaacccgct gatggcgcac ggcggctgca cggtgcgggc ggtgccgcgg gaggcgctcg
     1981 ccgaggcggt gcgcccccgg accgcactgg tcgcgctcag cgcggtgcac ccccaggacg
     2041 gccggatcgc cgacctggcc gccgtccggg acgccgcccg ggcgcacggg gcgctgacct
     2101 acgtcgacgt cacgcaggcg gcgggctggc tgccggtgcc gctggccgac ttcgactacg
     2161 cggtgtgcgg cgcctacaag tggctgctgt gtccgaaggg gacgacgttc accgtcttcg
     2221 gcggcgagcg cggcgagttg ggcggcccgg gatggccggt gccggcgcac gccggatggg
     2281 tcgcgggcga ggacccgggg gagtcgaact acggccccat cgaccggccg gcgccgaccg
     2341 cccgccgcta cgacgaaccg cacgccaact acgcctacgt gggcgccgag cactccctcg
     2401 ggctgctcgc ggagatcggg ctggcgacca tccacgcgca cgacgtggcg ctcgccgagc
     2461 agtaccgggc cgggctggtg gcggccggtt tcaccccgcg ggccgcgccc ggctccgcga
     2521 tcgtctccac ccccgggctg gcggacgccg aaccgcggct ggccgcggcc ggggtgcggg
     2581 tcgcggtgcg cggcgggctg ctccgggcgg cgttccatct ctacaactcc cgcgcggacg
     2641 tggaccgggc gctcgaactg ttggttccgt aacgcctcga ttgcccccgt tgccgtggtg
     2701 tttttgcagg ccaggggggg cgtggccggg gatacggggg ctgatctaat ggccaaggcg
     2761 gcggctcgaa gaggtgagtt ggcgccccgt gtccccccag ctgagaggcc gccagtgacc
     2821 accgcgttcg accccataga actcgccggc atcccgctcg ccaaccgcat cgtgatggcg
     2881 ccgatgaccc gcaaccgcgc caccgaggcg ggcgtgccca ccccctcgat ggtcacgtac
     2941 tacacccagc gggcgtcggc cggcctgatc gtcaccgagg ccacccagac cgaggtggtc
     3001 ggccgcggct acccgctcac gccgggtctg cacaccgccg agcaggtcgc gggctggcgc
     3061 cgggtcaccg actccgtcca cgcggccggc ggtcggatct tcgcccagct gtggcacggc
     3121 ggccggatcg gtcacccggt gctgctgccc gacgggctgg agccggtcgg cccgtccccg
     3181 gtgcgggcgg ccggccaggg cttcacccag aacggtccga cggacttcgt caccccgcgc
     3241 gagctgaccg acgaggagat ccgcgcgacc gtcgacgggt tcgcggccgc ggcccgcaac
     3301 gccatcgagg ccggcttcga cggggtggag atccacggcg ccaacggcta cctcgtccac
     3361 cagttcctgg cccccaacgc caacctgcgc accgacgcgt ggggcggctc cgacgcggcc
     3421 cgcgcccggt tcgccatcga ggtggtcaag gcggtcgccg aggcggtcgg cgcgcaccgc
     3481 accggtctgc ggctctcgcc cggcaacccg ttcaacgaca tcgccgagcc cgagccggag
     3541 gccacctaca ccgcgctgct ggacgccgtc tccccgctcg gcctggccta cctgcacacc
     3601 tgcgacgtcc acgaccttca gctgctggcc cggctgcgga agcggttcga cggcccgttc
     3661 ctgctcaacc cggccaccgt cggtcgcccc accggccccg aggagctgcc gctcgtcgag
     3721 cagggcgacg ccgatctgct ggcgtacggc gcgctgttca tcgccaaccc cgacctgccc
     3781 cgccgcctgg cggccggcgg cccgttcaac gccccggagc gggccagctt ctacggcggc
     3841 gacgaccacg gctacctgga ctacccggcc ctggaccata actgacgtca cgtcagatca
     3901 gcggtcgcgt cgaacggcgg aacgcggacg gccgccgcac agtgccacga ggggactgtg
     3961 cggcggccgt ccgccgaccg ggccgcccgc cgccgggccg ggcgggccga cggtttccta
     4021 cttgaccggt gcgaacgggg cccgcgcccc gatgtactcc gggcgcctga ccggcgccgc
     4081 gaacggctcc acggcggtgt tctccatgct gttgaagacg atgaagacgt tgctgcgcgg
     4141 gtagggcgtg atgttgtcgc cggagccgtg catggcgttg cagtcgaacc acgtcgccga
     4201 gccggccttg ccggtgaaca gccggatgcc gtgccggtcc gccagcgtcg tcagcgtccc
     4261 gtcggacggc gtgcccgcgt cctgcatctg cagcgacttc ttgtagttgt ccttcggggt
     4321 ggcgccctcg cacccgacga agtgccggtg cgaccccggc atgatcatca agccgccgtt
     4381 ggtgtcgtag ttctcggtca gcgcgatcga caccgacacc gtgcgcatgt tcggcaggcc
     4441 gtcctcggcg tgccaggtct cgaagtccga gtgccagtag aagccggagg caccgaaccc
     4501 gggcttgacg ttgatccgcg actggtggac gtagacgtcc gacccgagga tctggcgggc
     4561 ccggcccacc acgcgcggat cggagaccag ccgtgcgaac acgtcgctga tccggtgcac
     4621 ttcgaagacc gagcggacgt cctgcgtctg cggctcgacg atcgagcgcg ggtccgcgcg
     4681 cgtcgccggg tcgttcacca gccggtccag ctcggcgctg tacaccgcga cctcgcccgc
     4741 ggtgagcagc tccggcatgg cgaagaagcc gtcacggtcg aagtcgctca gctcggacgc
     4801 ggcgaagggg ccctccgcgc cgggccgcga ccacaccacc gggtcctgcc gcggggtgat
     4861 gacctctgag gtcccacggg tcgggtacag gtcggcggtg cgctcgggtg cggtggtcat
     4921 ggtggtgcct tcctctcctc tcgtacggaa tctcactgcg tcacggtgac gccggacggt
     4981 ggacggtccg gtgtccgcgc tcagctcgcc tcgggttcgg gctcggtgag cagcgggtag
     5041 acgccgttct cgtcgtggtc ctcacgaccg gtgaccggcg ggttgaagac gcacaggcag
     5101 cggaagtcct ccttgatccg catggtgtgc ttctcgtggc cgttgagcag gtacatcacg
     5161 ccgggcgtga tgaggtgctt ctcgccggtc tcgtcattgg tcagctcggc cacgccctcc
     5221 gtgcagacca cggcctcgat gtggttggcg taccacatcg aggtctcggt gccggcgtag
     5281 aggacggtct cgtggagcga gaagccgacc cgctccttgg cgagcacgat gcgcttgctc
     5341 tcccacgtgc cggacttggc cttgacgtgg cggtcggtgc cttcgatgtc cttgaacgag
     5401 cggacgatca tggtgcgttg gatgcctttc tgtggaacgg tgaggcgttg gacgacgggt
     5461 gcggtcaggc gcagtcgcgc accgcgcggg cgagggtccg caggccctcg tccagctcct
     5521 cgggggtggt cgtcagtgcg ggcagcagtt tgacgacctc gctctgcggg ccggaggtct
     5581 cgatgaggag ccccagctcg aaggcgcgct tggcgatctt gttggcgagc tccttgtcgg
     5641 tgcactccag gccccagacc agaccgcggc cgcggtactc ggcgaaggcg cccgggtgct
     5701 cggcgacgat ggccttcagg tgcccctcga cgatctcgcc gcggcccagc gtctgcttct
     5761 ccatctggcc gtcggcccag taggtgtcca gggcggcggc cgcggtgacg aaggccgggt
     5821 tgttgccgcg gaaggtgccg ttgtgctcgc cgggctccca gatgtccagc tccggcttga
     5881 acagggtcag ggccagcggg agcccgtagc cgctgatgga cttcgagacg gtgacgatgt
     5941 ccggcacgat gcccgcctcc tcgaaggaga agaaggcgcc ggttcggccg cagcccatct
     6001 ggatgtcgtc gacgatcagc agcatgtcct ggcgctcgca gagggcggcc agggcgcgca
     6061 gccagtcggc gcgggcgacg ttgatgccgc cctcgccctg cacggtctcc acgatcaccg
     6121 cggcgggctt gttcaggccc gagccctggt cctccagcag ccgctcgaac cacaggaagt
     6181 ccggcgtctg gccgtccagg tagttgtcga acggcatcgg ggtgccgtgc accagcggga
     6241 tgccggcgcc ggcccgcttc atggagttgc cggtgaccgc gagcgcaccc agcgacatgc
     6301 cgtggaaggc gttggtgaag gagacgatcg actcccgccc cttgaccttg cgggccagtt
     6361 tgagcgcggc ctcgaccgag ttggcgcccg tcgggcccgg gaacatgacc ttgtacggca
     6421 ggtcgcgcgg ccgcaggatg atgttctgga acgactccag gaaggcccgt ttggccgtgg
     6481 tggacatgtc cagcccgtgg gtgatgccgt cccgctcgat gtagtcgatc agggcgcgtt
     6541 tgaggaccgg gttgttgtgc ccgtagttga gcgagccggc gccggagaag aagtccaggt
     6601 aggtgtggcc gtcctcgtcg gtcaggcggc tgccctgcgc gcggtcgaag acggtgggcc
     6661 agccacggca gtagctgcgc acctccgact cgacggtttc gaagacgctc agatcgggct
     6721 gggtgatggt cacagcatgc tcctgggaga tgagtgcggg aaggagaagt ctgggggcgg
     6781 cgccgtgcgc gcggcccggg tcagcggttg ctgccgggcg gcgtctcgaa cgggcctatg
     6841 aggtgcagga cttccggctc gtggccctgt tcggggaaga gcgcggcgtc gaacagcacc
     6901 tcgcgcttga ccggcactga gtgccgtgcg gcgaaggagg cgaacagccg gttggaggcg
     6961 tcgttgtcgg gcgtgatggt ggtctccaca ctgcggacgc ccagttcgtc gatggcgcgg
     7021 gcggtcagcc cgtccaggag cgcggcggcc aggccccgtc cgcggtgcgc cgcgtcgacg
     7081 gcgatctgcc agacgacgag ggtgtccggg cggtcggggc gcaggtagcc ggtgacgaac
     7141 gcggctggct cgccggtcgc atcgcgggcg acggcggagg tggcggcgaa gtcgcggcac
     7201 cacaggaggt agctgtagga ggagttgagg tccagcgcct tcgagtcgcg ggcgatgcgc
     7261 cagatcgctg ccccgtcctc cacccggggg gtgtcgagct tgaagccctc cggaatttcc
     7321 ttgatatcgc ttcgggcacc ggcatggtct gcttgtgcgg cggtcatgca attgaattta
     7381 cccagccgaa aactaaattg catcgcggga ctgggttacg caggaggcgt ctgtgtgtta
     7441 tcacgcgggg gtgcgcgagc gcgcgatccg gcggcaagtt gtcacgattc gtcacggaag
     7501 ttcggggcga aacggacacg ttgtgtagtc ggtcacagct cggtaacgct cccgtgcagt
     7561 gcctgaataa tgagactcga cgctagcgaa atcttggcgt ttgaggttcg agaaagcggg
     7621 catacgaata cgggaagctg gcttctgggg aatttgggaa ttcgtcgccg gaaggtgtcg
     7681 cggacgattc accaaaacgg acacgggaag tcaccggagt tccaccccga agagacccgg
     7741 aagagatgcg ggaagcgtcg cggcgtgtta cgcgaagcgg cggggcgcgc ataccgcgga
     7801 taccggggca tgattgttgc gaaatcgccc gccgggcggg ccgcggcggg cgcccggcgc
     7861 accgtggtcg cccgccgcgg cccccgcata cagtgcctgc atgacgtcca tgagtgaagg
     7921 tgcggcgctg cacctcaagg ggagggtgct cgtcgggccg gacgaggtcc gcgacgagct
     7981 gtgggtcatc gacggccggg tgacgttcga gcgaccttcg gtggcacggg atgtcacgac
     8041 gctgtcgggg tgggtgctcc ccgggctggt cgacgcccac tgtcacgtcg ggctcgacgc
     8101 gcacggaccg gtggacgcgg ccaccagcga gaagcaggcg ctcaccgacc gtgacgccgg
     8161 caccctcctg atccgggacg ccggctcgcc ctcggacacc cgctggatcg acgaccgccc
     8221 cgacctgccg cgaatcatcc gcgccggccg gcacatcgcc cgcacccggc gctacatccg
     8281 caactacgcg cacgagatcg agccggcgga cctggtcgcc tacgtggccc aggaggcccg
     8341 gcgcggcgac ggctgggtca agctcgtcgg cgactggatc gaccgttcgg tgggcgatct
     8401 ggccgcctgc tggccgcccg gcgaggtggc cgcggccatc gccgaggcgc accggctcgg
     8461 cgcccgggtc accgcgcact gcttcgccga ggagtccctc gccccgctgg tcgaggccgg
     8521 gatcgactgc atcgagcacg ccaccggcct gaccgaggac accatcccgc tcttcgccga
     8581 gcggcaggtc gccatcgtcc ccaccctggt caacatcgcg accttcccgc agctcgccga
     8641 cggtggcgag gcgaagttcc cgcgctggtc cgcgcacatg cgccggctgc acgagcggcg
     8701 ctacgacacg gtgcgggccg cctacgacgc cggggtgccg atcttcgccg gcaccgacgc
     8761 cggcggctcg ctgccgcacg gcttggtcgc cgacgaggtg gccgagctga tgaaggccgg
     8821 gctgcccgtc gaggccgccc tctcggcgac gacctggggc gcccgcacct ggctgggccg
     8881 ccccggcctg accgaaggcg ccccggccga cctggtcgtc ttcgagaccg atccgcgggc
     8941 cgacgtccgg gtgctggcgg cgccccgcct ggtggtgctg cgcggccgga tcgtcggctg
     9001 agccgccgcg ggccgctgcg ggcggctcac gcgccgggcg ccgcgggttc cgccggggtg
     9061 tcccgctccg ccgcgtcggc ccgcagcagc gcgtccacca ggccggggaa gcgggtttcg
     9121 aggtcggtgc ggcgcagcga gatgtaccgc tcgcggccgg cgcggcgggt gtgcgtccag
     9181 cccgccgtcc gcaggatccg gaagtggtag ctgccggtgg cccgggtcac cggcagttcg
     9241 atgtccccgc agcccgcttc gccctgggtg gcgagccggc gcacgatccg tcgccgcagc
     9301 gggtcgctga acgcctggag caggtcgccg agctggatcc gcgcggtctc gggctggtcg
     9361 gggtcggccg gcggggaggt ggcgctgggg tctgcgccgg gggcgccgcc cggggccgta
     9421 cgagtcattg ttcgagaacc ctctaaacga gtgatacggt cggtgatcgt caatgtgttg
     9481 acgatcctct aattattcac cgacggcgac ggcgcccgac accacccgcg gccgggcccg
     9541 cccgcccgtc ggcaccgacg ctcccgcgag gctccgcgat gaccaccgcc gacccggcac
     9601 ccccctccgc ccccgcagcc gcccccaccg aggacccgtc ctccgcgggc ccgctgcgca
     9661 cgctgttctg catcggcgtg acccaggact tcttcgccgc cgacgacgac cggcgcgccg
     9721 ccgtggccgc cgcgatcccg ccggccttcg accggctcgg cgcgcgcttc ggcgtcaccg
     9781 tgctgggcac cctggacgac gaccagctga tggtcggcgc caccaccgcc tggccgtgga
     9841 cctcctacgt cctcgccgac gtccccgacc tggacaccgt cgccgcggtg tgcggcatcg
     9901 tccgcgacac cccggtcggc gacgggcggc tctggcgcta cctgcgcatc gaggcccgcg
     9961 tcggccgccc gctcttcttc gccacggcct gagggggacc accgtgctcg acaccggact
    10021 cgacggccgg accgtcctga tcaccggcag cgcccagggg ctcggcgccg cgctggtccg
    10081 cgcctgccac gccgagggtg cccacgtggc cgcgctggac gtcgacgagg aggccaaccg
    10141 cgccctcgcc gagcggctcg accccgccgg ggaacggatc cggccggtcc gcgccgacct
    10201 gcgcgacgtg gacgccctcg ccgccgccta cgacgacgtc cgggcctggc gcccggtcga
    10261 cgtgctgatc aacaacgccg cccggccgct cgcccggacg ctgtgggaga tcacccccga
    10321 ggagtgggac gaggtcttcg cggtcaacct ccgcgcggtc ttcctgctga cccgcgcggt
    10381 cggcgccgac atgcgtgagc gcggcttcgg g
//
