LOCUS       NZ_CP119144            23353 bp    DNA     linear   CON 22-NOV-2023
DEFINITION  Streptomyces noursei strain C27 chromosome, complete genome.
ACCESSION   NZ_CP119144
VERSION     NZ_CP119144.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces noursei
  ORGANISM  Streptomyces noursei
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 9627936)
  AUTHORS   Go,B. and Lu,Y.
  TITLE     Control effect and mechanism of Streptomyces NK27 against gray mold
            of grape
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 9627936)
  AUTHORS   Go,B. and Lu,Y.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-FEB-2023) State Key Laboratory for Biology of Plant
            Diseases and Insect Pests, Institute of Plant Protection, Chinese
            Academy of Agricultural Sciences, Yuanmingyuan, Beijing 100193,
            China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 01-OCT-2021
            Assembly Method                   :: ABySS v. 2.3
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 98x
            Sequencing Technology             :: Complete Genomics
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 11/22/2023 14:00:30
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,442
            CDSs (total)                      :: 8,348
            Genes (coding)                    :: 8,203
            CDSs (with protein)               :: 8,203
            Genes (RNA)                       :: 94
            rRNAs                             :: 7, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 145
            CDSs (without protein)            :: 145
            Pseudo Genes (ambiguous residues) :: 0 of 145
            Pseudo Genes (frameshifted)       :: 46 of 145
            Pseudo Genes (incomplete)         :: 121 of 145
            Pseudo Genes (internal stop)      :: 12 of 145
            Pseudo Genes (multiple problems)  :: 30 of 145
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 16:17:19
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 4345395
            Orig. end                         :: 4368748
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP119144.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..23353
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="azole-containing-RiPP"
                     /region_number="24"
                     /rules="((YcaO or TIGR03604) and (((thio_amide and (PF06968
                     or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N
                     or (PF06968 or PF04055 or PF07366)) or (goadsporin_like or
                     PF00881 or TIGR03605)) or TIGR03882 or TIGR03603 or
                     thiostrepton or TIGR03602)"
                     /tool="antismash"
     cand_cluster    1..23353
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="((YcaO or TIGR03604) and (((thio_amide
                     and (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /kind="single"
                     /product="azole-containing-RiPP"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..23353
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:13353](-)"
                     /cutoff="10000"
                     /detection_rule="((YcaO or TIGR03604) and (((thio_amide and
                     (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /neighbourhood="10000"
                     /product="azole-containing-RiPP"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..13353)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="((YcaO or TIGR03604) and (((thio_amide and
                     (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /neighbourhood="10000"
                     /product="azole-containing-RiPP"
                     /protocluster_number="1"
     misc_feature    85..99
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 16.75"
                     /tool="antismash"
     misc_feature    484..498
                     /note="TFBS match to OsdR, Development and stress
                     management regulator, confidence: medium, score: 26.9"
                     /tool="antismash"
     misc_feature    721..735
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 18.19"
                     /tool="antismash"
     misc_feature    complement(1017..1028)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: medium, score: 17.11"
                     /tool="antismash"
     gene            1032..1616
                     /locus_tag="P0D74_RS18820"
     CDS             1032..1616
                     /GO_component="GO:0009986 - cell surface [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:TIGR01167.1"
                     /locus_tag="P0D74_RS18820"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="LPXTG cell wall anchor domain-containing protein"
                     /protein_id="WP_275463697.1"
                     /transl_table=11
                     /translation="MGGNPAPGRTSSRVKAPPGATVDELEQPTVNPSRTARPSRTRRAA
                     GAGLLAAMALAAVSTTGTAYAAPASALASGPAASASPSPVPTQPPGHGSGPSAEPTQPP
                     SHSSAPSAEPTYPPGHSATPSPVPPRGTAAPSPVPSQPGSRPAPGKDTGDGQQLAKTGA
                     SSGTTLALGAGAAALIAVGGGALYVVRRNRA"
     gene            1642..2316
                     /locus_tag="P0D74_RS18825"
     CDS             1642..2316
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0016987 - sigma factor activity [Evidence
                     IEA]"
                     /GO_process="GO:0006352 - DNA-templated transcription
                     initiation [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1032: RNA
                     polymerase, sigma-24 subunit, ECF subfamily"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016577449.1"
                     /locus_tag="P0D74_RS18825"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="SigE family RNA polymerase sigma factor"
                     /protein_id="WP_275463698.1"
                     /transl_table=11
                     /translation="MAHYAPHPAPAGFALPGLRRAAWRRLLRAVRRESPARHSASVHQL
                     PASARQSAHAWDDAPEPHRPTLTELYHAHRLKMVRLAILLVDDRATAEDVVQDAFAALY
                     KRHGEQLGEVDNALAYLRTTVVNAARSVLRRRRTAREYTPPHEADAPSADERVVLDEEH
                     REVLAALGALTARRREVLVLRYWGDLTEAQIATTLGISRGAVKSLASRALDALEKILEE
                     RS"
     gene            2313..2906
                     /locus_tag="P0D74_RS18830"
     CDS             2313..2906
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="P0D74_RS18830"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_275463699.1"
                     /transl_table=11
                     /translation="MSTRDTAPWDATGERPVEDRLRRALAARADAVDVHDLRPAAPPGP
                     RPGRSRPSWLALRTAFRPRRLALPLAAAATAAVVALAAHLATTSDRAPAPPQPAAPPNP
                     ATPSPRGATPTPVPSPSAPGRSTEPGRGPLGTAPGTPSRRPTPSTAPPVPTSWPSGRAT
                     GGATGGAEPSGLPTPATSTPSAPPSTAKASPGVR"
     gene            2952..3602
                     /locus_tag="P0D74_RS18835"
     CDS             2952..3602
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016572549.1"
                     /locus_tag="P0D74_RS18835"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF4232 domain-containing protein"
                     /protein_id="WP_275463700.1"
                     /transl_table=11
                     /translation="MPLRPAPSPPTTSGCTGAARRARPLAAAVLAAAAALPLAACQNAG
                     GERDAAGPRTVAAPSPTAGAHPRDRNACTPDMLRFHAGAELHRDRRMLLTVTNVADRTC
                     TFAAQPYPLLHFGDRLPGPLPPLPYSRPRTPVVLLPDGTAYAEVLTAAAPGGPGGRSAP
                     ASTTEKASQFGIALTTRTTPTQVGVDGRAPIRVDPGTAAVTYWQPGPPAPGRW"
     gene            3781..4080
                     /locus_tag="P0D74_RS18840"
     CDS             3781..4080
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016572550.1"
                     /locus_tag="P0D74_RS18840"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="type II toxin-antitoxin system VapB family
                     antitoxin"
                     /protein_id="WP_016572550.1"
                     /transl_table=11
                     /translation="MIFKRIGNGRPYPDHGRESTRQWADVAPRPVRLDQLVTTKQQLDL
                     ETLLAEDSTFYGDLFAHVVKWEGDLYLEDGLHRAVRAALQQRQVLHARVLELDN"
     misc_feature    complement(3793..3809)
                     /note="TFBS match to NtrC, Nitrogen regulatory protein C,
                     confidence: medium, score: 23.99"
                     /tool="antismash"
     misc_feature    4180..4196
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: weak, score: 19.24"
                     /tool="antismash"
     gene            4226..4867
                     /locus_tag="P0D74_RS18845"
     CDS             4226..4867
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014155094.1"
                     /locus_tag="P0D74_RS18845"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="LytR C-terminal domain-containing protein"
                     /protein_id="WP_275463701.1"
                     /transl_table=11
                     /translation="MSMLTPPGMGGKYRITGDRYPRMRRPRHRRRIILSIVASACALGL
                     VGWGTLQLIDVFGGRGSTAQAAQDTRPCPDGTGGPAKAAPSAAKPPAPASLTVNVYNAT
                     PRSGLAKRTADELQKRGFKIGKVGNAPAAYDKKVAGTGMLLGPATATGGALKVLATQLA
                     GAQLKTDDRKGADLDLIIGGAFKELTAPQQAAKALALLTRPAQAPAPAKC"
     gene            complement(4941..5576)
                     /gene="upp"
                     /locus_tag="P0D74_RS18850"
     CDS             complement(4941..5576)
                     /EC_number="2.4.2.9"
                     /GO_function="GO:0004845 - uracil phosphoribosyltransferase
                     activity [Evidence IEA]"
                     /GO_process="GO:0009116 - nucleoside metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="upp"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004943140.1"
                     /locus_tag="P0D74_RS18850"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="uracil phosphoribosyltransferase"
                     /protein_id="WP_016572552.1"
                     /transl_table=11
                     /translation="MRIHVVDHPLVAHKLTTLRDKRTDSPTFRRLADELVTLLAYEATR
                     DVRTEQVDIETPVTATTGVRLSHPRPMVVPILRAGLGMLDGMVRLLPTAEVGFMGMVRN
                     EETYEAHTYATRMPDDLSGRQVYVVDPMLATGGTLVAAIKELIKRGADDVTAICLLAAP
                     EGVEVMERELAGTPVTVVTAAVDEQLNADRYIVPGLGDAGDRMYGTAG"
     gene            5793..6317
                     /locus_tag="P0D74_RS18855"
     CDS             5793..6317
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016572553.1"
                     /locus_tag="P0D74_RS18855"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_275463702.1"
                     /transl_table=11
                     /translation="MYFAALLARTEDGWEASDTELDDVETLTDLTDLAREAAADDTVVV
                     LIEQEDAWFGVVRIDGEDDPRVFVSNAAMAARSSYGTMLTDELLGRDDDADDLDLLDLD
                     GTEDGEPETEDEDPEDRDADEAPVARGPLGDARLLEDVGVGERELLTLDGDALGSIAEA
                     LGCSDLLEAVR"
     gene            6385..6885
                     /gene="tadA"
                     /locus_tag="P0D74_RS18860"
     CDS             6385..6885
                     /EC_number="3.5.4.33"
                     /GO_function="GO:0008251 - tRNA-specific adenosine
                     deaminase activity [Evidence IEA]"
                     /GO_function="GO:0008270 - zinc ion binding [Evidence IEA]"
                     /GO_process="GO:0002100 - tRNA wobble adenosine to inosine
                     editing [Evidence IEA]"
                     /codon_start=1
                     /gene="tadA"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1240: riboflavin biosynthesis protein RibD"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018536602.1"
                     /locus_tag="P0D74_RS18860"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="tRNA adenosine(34) deaminase TadA"
                     /protein_id="WP_020930784.1"
                     /transl_table=11
                     /translation="MTVPPSASLPSPTPDPLRDPWTGPMRRALAEAARAPGTGDVPVGA
                     VVLSADGTVLGTGHNEREATGDPTAHAEVLALRAAARTVGQWRLTGCTLLVTLEPCTMC
                     AGAIVLSRVDRVVYGARDAKAGAVGSLWDVVRDRRLNHRPEVVTGVLEADCAALLTAFF
                     RDR"
     tRNA            6954..7041
                     /anticodon=(pos:4352383..4352385,aa:Ser,seq:cga)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="P0D74_RS18865"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /product="tRNA-Ser"
     gene            6954..7041
                     /locus_tag="P0D74_RS18865"
     gene            7283..8170
                     /locus_tag="P0D74_RS18870"
     CDS             7283..8170
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1014: LysR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016572555.1"
                     /locus_tag="P0D74_RS18870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="LysR family transcriptional regulator"
                     /protein_id="WP_275463703.1"
                     /transl_table=11
                     /translation="MSLRQFEYALAVAEEGSVTAAAERLRVAQPSVSQQIRGLERDLGV
                     ELFARTPTGLVPTVVGRAFLRDAQAAVNAARRARATARAGAEELVGELVVTVQMGFGTR
                     QLPGALGALRRRFPRVEVTVFEEPSSAEMDRLCRRGALDLALMAKCERTPANAHHLGDE
                     EFVVVLGAGHPQLAAERVELRELAGEPWVRFDRDSALDGVLLEVLRDNGPTPTTAARVS
                     QTATAVRWAAHGMGATLVPASAVPSGHEHLVRPVFPAVSQPVIAVVRPVAGPAETALLE
                     LLRQETWSEPVAQR"
     gene            complement(8178..8921)
                     /locus_tag="P0D74_RS18875"
     CDS             complement(8178..8921)
                     /NRPS_PKS="Domain: PKS_KR (9-173). E-value: 3.5e-18. Score:
                     58.1. Matches aSDomain:
                     nrpspksdomains_P0D74_RS18875_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short_C2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011028373.1"
                     /locus_tag="P0D74_RS18875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="SDR family oxidoreductase"
                     /protein_id="WP_275463704.1"
                     /sec_met_domain="adh_short (E-value: 7.9e-34, bitscore:
                     116.1, seeds: 230, tool: rule-based-clusters)"
                     /sec_met_domain="adh_short_C2 (E-value: 1e-32, bitscore:
                     113.0, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGKYSGKNAVITGGGSGIGLATAKLLVDEGARVVITGRSRTTLDA
                     ALEHLGPHAVAVRGDVAALPDLDALADRVRGELGTLDALFVNAGIATLTPFASTTEKAY
                     DELFAINVKGAYFSVQKLAPLLNTGAGVVLTTSVANVLGVPETSVYAAGKAALRSMARS
                     LSRELLPRGIRVNAVSPGPVDTGVLEGTLTPEAAEQFKAQQVAGNPMRRFGTPEEIAGA
                     AAFLAFDATYTAGAELVVDGGATQL"
     aSDomain        complement(8403..8894)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_P0D74_RS18875_PKS_KR.1"
                     /evalue="3.50E-18"
                     /label="P0D74_RS18875_PKS_KR.1"
                     /locus_tag="P0D74_RS18875"
                     /protein_end="173"
                     /protein_start="9"
                     /score="58.1"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="VITGGGSGIGLATAKLLVDEGARVVITGRSRTTLDAALEHLGPHA
                     VAVRGDVAALPDLDALADRVRGELGTLDALFVNAGIATLTPFASTTEKAYDELFAINVK
                     GAYFSVQKLAPLLNTGAGVVLTTSVANVLGVPETSVYAAGKAALRSMARSLSRELLPRG
                     I"
     CDS_motif       complement(8805..8894)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_P0D74_RS18875_0001"
                     /evalue="1.10E-08"
                     /label="PKSI-KR_m1"
                     /locus_tag="P0D74_RS18875"
                     /protein_end="39"
                     /protein_start="9"
                     /score="27.7"
                     /tool="antismash"
                     /translation="VITGGGSGIGLATAKLLVDEGARVVITGRS"
     misc_feature    8980..8994
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 16.71"
                     /tool="antismash"
     misc_feature    8983..8996
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 13.33"
                     /tool="antismash"
     misc_feature    complement(8984..8997)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 14.22"
                     /tool="antismash"
     misc_feature    8984..8998
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 15.44"
                     /tool="antismash"
     misc_feature    complement(8985..8998)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 16.95"
                     /tool="antismash"
     gene            complement(9021..9797)
                     /locus_tag="P0D74_RS18880"
     CDS             complement(9021..9797)
                     /NRPS_PKS="Domain: PKS_KR (18-167). E-value: 2e-09. Score:
                     29.6. Matches aSDomain:
                     nrpspksdomains_P0D74_RS18880_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short_C2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016572557.1"
                     /locus_tag="P0D74_RS18880"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="SDR family oxidoreductase"
                     /protein_id="WP_275463705.1"
                     /sec_met_domain="adh_short_C2 (E-value: 5.6e-31, bitscore:
                     107.3, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTSETGRGTRELAGKRALVTGGTRGIGAAVVRQLLAAGAEVLTT
                     ARTAPDTVPQGAAFVAADVQTRAGAEALAAAAQETLGGVDVVVHNAGGARPHAGASAIP
                     DEEWQAALDLNFLSSVRLDALLAPGMRERRSGAIVHVSSAAVRTPVGQFLHYTTAKAAL
                     ENYSRGLSLELAPFGIRVNTVSPGRTATPGGEATREEWARLNAAPGQTNAADAPPLGRD
                     GRPDDIADAVLFLVSDRAGWLTGSNLVVDGGEFPRG"
     aSDomain        complement(9297..9743)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_P0D74_RS18880_PKS_KR.1"
                     /evalue="2.00E-09"
                     /label="P0D74_RS18880_PKS_KR.1"
                     /locus_tag="P0D74_RS18880"
                     /protein_end="167"
                     /protein_start="18"
                     /score="29.6"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="LVTGGTRGIGAAVVRQLLAAGAEVLTTARTAPDTVPQGAAFVAAD
                     VQTRAGAEALAAAAQETLGGVDVVVHNAGGARPHAGASAIPDEEWQAALDLNFLSSVRL
                     DALLAPGMRERRSGAIVHVSSAAVRTPVGQFLHYTTAKAALENYS"
     CDS_motif       complement(9675..9743)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_P0D74_RS18880_0001"
                     /evalue="6.70E-06"
                     /label="PKSI-KR_m1"
                     /locus_tag="P0D74_RS18880"
                     /protein_end="41"
                     /protein_start="18"
                     /score="18.8"
                     /tool="antismash"
                     /translation="LVTGGTRGIGAAVVRQLLAAGAE"
     misc_feature    9867..9880
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 16.02"
                     /tool="antismash"
     misc_feature    9922..9933
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: medium, score: 19.28"
                     /tool="antismash"
     gene            complement(10001..11158)
                     /locus_tag="P0D74_RS18885"
     CDS             complement(10001..11158)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: PF00881"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016572558.1"
                     /locus_tag="P0D74_RS18885"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="SagB family peptide dehydrogenase"
                     /protein_id="WP_275463706.1"
                     /sec_met_domain="PF00881 (E-value: 2.1e-15, bitscore: 56.1,
                     seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDDTTAHDAPGAPNGAPDHDARPYRRNPDLLLEWADGGGPVLVDC
                     GSWRKFAAKPVLVDLLNHLDRPRTADQLQDRWRESATGGDVRTLLDRLAAAGILRRCAP
                     PPTDVAEDAEDAEDAAKDPGAGWTAYERAVHARSGLGPDAAAGRGTPPPARLHHPGVDA
                     VIALPDGAGAPSRPLVDVLAARRSVRGYAPDPVPLPLLAALLARAARVRGHLAPRAYQQ
                     TQRPAPSGGARHSLEVHLVARAVAGLAPGAYHYDPFAHALHRLAPWTDDLAAFQQRTVT
                     DPALLDHAPPASLCLTAVAARTTWKYEGMALSLIYRDTGCLMQTLSLTATDLGLASCLT
                     GRMEAPFTAPFLPPSLRAHLSHVGNMALGLPTSPLAAPDVTPLDL"
     gene            complement(11230..13353)
                     /locus_tag="P0D74_RS18890"
     CDS             complement(11230..13353)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: YcaO"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: TIGR03604"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018536604.1"
                     /locus_tag="P0D74_RS18890"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="YcaO-like family protein"
                     /protein_id="WP_275463707.1"
                     /sec_met_domain="TIGR03604 (E-value: 5.7e-80, bitscore:
                     267.8, seeds: 25, tool: rule-based-clusters)"
                     /sec_met_domain="YcaO (E-value: 1.1e-70, bitscore: 237.8,
                     seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="METPRPPAPLTLRRDVRLVSSGRHLYVCASTGTLRVPVHLPTDDA
                     DHRTVTLDAVPERVAEGLHARGLAHPGDGRLPHPLYGTGAERGRRPVVVVGDGPLATDV
                     VALLERAGARTAPADTTDQPAAVVLPLGLPEDELRRRTTLVLDHGTPLVTYLSTPTRLL
                     LATLSPPHTPCPVCLVRRIRANHTWQPVAGLPLDLLLGAAQSEAWPTTAVAAGAVAHAV
                     LTALAAPEAPTGPPELTELDHATWERTGHALFHTPGCPACASAAVPPKRDGTAAVDVAE
                     SWRLMRGAVDPLTGLVPELRVDEPSGPDGTTYARTAGMTTTTWLSPVAAEARGGAVKSD
                     PVNARVCAVGETMERYAAGVYDPDRLVRATLAELGDAAIDPRSLPLGSDQEYAAQRRYA
                     PFDPAVPIDWVAGTSLATGRPRYVPACAVYLPYRFPRAHKPWFDPISTGLAAGGSYHHA
                     VLGGLMESVERDATLVFWENRLTLPGLDLTGLPDGPARRIVDRITAEGATVTCKDLTTD
                     LGIPAVAVRFAGGTAERPVVVHAARADLDPHTALLGALEEACLCRTGAGIWLEEGEVPA
                     ADAALSSLSEFCLYYCAPDRQHHLAFWADGPLHPLPAARPAGSLQDDVAEAVRRLAARG
                     HEAIAVDLTPIDVAECGVSVVRTVVPGLCPLTLRSDFHRRGGPRVRQAPVAMGVRATAL
                     TEDQLNPWPLPFL"
     gene            complement(13442..13561)
                     /locus_tag="P0D74_RS18895"
     CDS             complement(13442..13561)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF033434.1"
                     /locus_tag="P0D74_RS18895"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="azolemycin family RiPP peptide"
                     /protein_id="WP_275463708.1"
                     /transl_table=11
                     /translation="MAEEDDLFEEMVIPESETAFAGHSCLCFVTEYDDTESAE"
     misc_feature    complement(13708..13723)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 15.69"
                     /tool="antismash"
     misc_feature    complement(13830..13846)
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: weak, score: 19.29"
                     /tool="antismash"
     misc_feature    13874..13885
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 16.61"
                     /tool="antismash"
     gene            complement(13964..14443)
                     /locus_tag="P0D74_RS18900"
     CDS             complement(13964..14443)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016574697.1"
                     /locus_tag="P0D74_RS18900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_275463709.1"
                     /transl_table=11
                     /translation="MRPKHTNSAHRQSGSPHAPVRRTWGRRPMVVLALLFGMVAAAAGP
                     AAAAGLSDAAAARPAAVAAPHAASGARTTAVDAERVEAAAAAPAKWRHSTHSSHRQVTH
                     QASFTSHDKPKKKKMGFFKKLGVFLIVIVVAIIVIVILLIWLIVHFIRKAFRRRD"
     gene            complement(14472..15257)
                     /locus_tag="P0D74_RS18905"
     CDS             complement(14472..15257)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018536607.1"
                     /locus_tag="P0D74_RS18905"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF2127 domain-containing protein"
                     /protein_id="WP_275463710.1"
                     /transl_table=11
                     /translation="MKIDWNRRTCARRGHITYLPDETHLQERLHAGTALGTAWRCLRCG
                     DFVLGEPHGSGPACDAPLVPRGKALRDLFILRFLAVERALRGLFVVLAALAVWQFSNSQ
                     DAVRQFFDKNLDVVRPIAVHFHYDLDHSPVVDTIRKTFGYQHSTLLLVAGLLLAYALVE
                     IVEGVGLWLSQRWAEYLAVVATAAFLPLEIYELTEKVSWLKIATLVVNILAVLYIAVAK
                     RLFGLRGGRAAFDEERHSASLMEVETSAGVSAPASAHNG"
     misc_feature    complement(15394..15414)
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 18.93"
                     /tool="antismash"
     misc_feature    complement(15737..15751)
                     /note="TFBS match to OsdR, Development and stress
                     management regulator, confidence: strong, score: 29.3"
                     /tool="antismash"
     gene            15888..16052
                     /locus_tag="P0D74_RS18910"
     CDS             15888..16052
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019887721.1"
                     /locus_tag="P0D74_RS18910"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_016574699.1"
                     /transl_table=11
                     /translation="MATAKKVALYLVVIFVLWTIIATPKRAAGLVQIGFEGISTAAQSV
                     GQFMTQLVS"
     gene            16109..16402
                     /locus_tag="P0D74_RS18915"
     CDS             16109..16402
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010056642.1"
                     /locus_tag="P0D74_RS18915"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="Dabb family protein"
                     /protein_id="WP_275463711.1"
                     /transl_table=11
                     /translation="MIRHLVLFKLNEGVSRDEERVQAGVRAFAALETEIPELTFWECAW
                     NITDRPIAYDFAINSAVADTDALKRYIEHPAHQAAAAQWREFATWVIADYEF"
     misc_feature    16589..16605
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 16.34"
                     /tool="antismash"
     gene            16667..17476
                     /locus_tag="P0D74_RS18920"
     CDS             16667..17476
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014177816.1"
                     /locus_tag="P0D74_RS18920"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="RNA polymerase sigma factor SigF"
                     /protein_id="WP_016575579.1"
                     /transl_table=11
                     /translation="MTVTARTAPKAPARESRSADTRALTQVLFAELAGLTPGTPEHSRV
                     RAALIEANLPLVRYAAARFRSRNEPMEDVIQVGTIGLINAIDRFDPERGVQFPTFAMPT
                     VVGEIKRYFRDNVRTVHVPRRLHELWVQVNGATEDLTVLHGRSPTTAEIAERLKIGEDE
                     VLACLEAGRSYHATSLEAAQEGDGLPGLLDRLGYEDPELAGVEHRDLVRHLLVQLPERE
                     QRILLLRYYSNLTQSQISAELGVSQMHVSRLLSRSFARLRSANRIDA"
     gene            17667..18506
                     /locus_tag="P0D74_RS18925"
     CDS             17667..18506
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006604265.1"
                     /locus_tag="P0D74_RS18925"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="RNA polymerase sigma factor SigF"
                     /protein_id="WP_037635852.1"
                     /transl_table=11
                     /translation="MSVELGSSKVLPAIPAPAPHVHDDVDAINTRSLSRSLFLRLATLD
                     KDSAERAYVRDTLIELNLPLVRYAAARFRSRNEPMEDIVQVGTIGLIKAIDRFDCERGV
                     EFPTFAMPTVVGEIKRFFRDTSWSVRVPRRLQELRLALTKASDELSQKLDRSPTVPELA
                     VCLGVSEEDVVDGLAVGNAYTASSLDSPSPEDDGGEGSLADRLGYEDSALEGVEYRESL
                     KPLLAKLPPRERQIIMLRFFANMTQSQIGEEVGISQMHVSRLLTRTLAQLREGLISD"
     gene            18760..19557
                     /locus_tag="P0D74_RS18930"
     CDS             18760..19557
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018536612.1"
                     /locus_tag="P0D74_RS18930"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_275463712.1"
                     /transl_table=11
                     /translation="MRRTTPVAYVATASAAVFCLGGVLTGCGSAAGSGYAAVGAAGPAD
                     PSAPTRPAPPRGGVELAPLEGGGATGPSTSPGSPGSSGPSGPSRPTAPDTTGTTPPGTP
                     GASDGSGTQPSAPPGSTTGQGGNPPGTKPPAPPGGSPAPGPGGSTTPEPPSPTIPAGPN
                     APSGLVVGKPVLADTDVRWCQRVTIDFLNTGQHPVTAGTVTFGSHVIGALGIDWATLDS
                     TRDLPLPLSPGKPATGTWRVCVDAWRVPLGMHLDTKDVTFKWK"
     gene            complement(19643..20767)
                     /locus_tag="P0D74_RS18935"
     CDS             complement(19643..20767)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PCMT"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018093477.1"
                     /locus_tag="P0D74_RS18935"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="methyltransferase domain-containing protein"
                     /protein_id="WP_275463713.1"
                     /sec_met_domain="PCMT (E-value: 1.6e-29, bitscore: 102.1,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTDRLGAPVPARLRAAFRAVPRHLFLPPTLWLRDGSGGYEPCERE
                     REPDRWWRAAYRDASLVTQFTELSDGDLVPSSSASMPSVVARMLMALDDQRGLRVLEIG
                     TGTGFNAALLSYLFGAENVTSIDVDPVLVRRAEQGLKASGQRPEVRCADGAAGWRPTAP
                     YDAIISTCAVRTVPLPWLEQVAAGGRIVTPWDTAWCNYGTLVATKQADGTAEGALAPYG
                     SFMLMRAQQTHVELRRDVLRDGQHPERSTTRLSPWSVAGDDLDAQIYMGLHVPGAWHSW
                     DTEVEGAHTRLWLADDQATSWASVDYDGRQTSTFAVAQYGVRKLWDEVARAYGQYVAAD
                     RPDIDRLRLRVWAEGRGTRHEVRLSAGRGEPAAP"
     gene            21178..21654
                     /locus_tag="P0D74_RS18940"
     CDS             21178..21654
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016572902.1"
                     /locus_tag="P0D74_RS18940"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="VOC family protein"
                     /protein_id="WP_275463714.1"
                     /transl_table=11
                     /translation="MPKITPNLWFDTQGMEAAEFYCSVFPNSKIKNVTHYTEGSPGTPG
                     TVLTVEFELDGREFTALNGGPQFTFDEAISFAVTCADQEEIDHYWTKLSEGGEEGPCGW
                     LKDKYGLSWQVVPDGMADILNDPDRARAARAMQAVMGMKKLDIAAIRAAADGKG"
     gene            complement(21731..22855)
                     /locus_tag="P0D74_RS18945"
     CDS             complement(21731..22855)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PCMT"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016572903.1"
                     /locus_tag="P0D74_RS18945"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="methyltransferase domain-containing protein"
                     /protein_id="WP_275463715.1"
                     /sec_met_domain="PCMT (E-value: 1e-31, bitscore: 109.2,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAARLVADGALTAEWEPVFEGLPRAGFLPDVFWQHHVATGEVEAV
                     DRRRDPQRWCEAAGSIHPLVTQWDDGEHEGPGRGRVASSSASAPSVVAAMLRDLTVRSG
                     QRVLEIGTGTGWNAALLASRLGAENVTTVEVDSSVAETARGALERQGLEAVTVVCGDGF
                     QGYPPRAPYDRIIATCGVHTFPRAWREQCRPGGVIVVPWGTRFTSTEATVALTVAADGR
                     SASGTFKDLVQFMSLRAQRREVPQYADYVTAESRDKAERGATTLTWDETIAGEWDISRF
                     VLGLLVPDCTVILDEPQEGQRPVWLCSLTDDRSWACVLFREDRPESTVYQHGDRRLWDE
                     VEAAYGWWQGQGRPGLGRLGLTVDDDGQHVWVEK"
     gene            complement(22873..23004)
                     /locus_tag="P0D74_RS18950"
     CDS             complement(22873..23004)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014627216.1"
                     /locus_tag="P0D74_RS18950"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_275463716.1"
                     /transl_table=11
                     /translation="MGKRDKPDDSGKPDKLPGQPWTPPKEPPQTDGGAPKGGGKRGK"
     misc_feature    23146..23158
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 19.27"
                     /tool="antismash"
     misc_feature    23312..23321
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 18.16"
                     /tool="antismash"
ORIGIN
        1 gcgggatctc cgagccgatg ccggtcgccg cgaccttcgc cgtcccgcgc gacgacggcg
       61 ccaccctggg cgacctggcg cgcctggaca ccatggtcac cgtcgtcgac gccgccgcct
      121 tcctgcccga actcgccggc ggcgacgccc tggtggagcg cggcctggcc ccgtacgagg
      181 acgacgagcg cacggtcagc gacctgctga tggaccagat cgagttcgcc gacgtcctcg
      241 tcctcaacaa gacggacctg gtcgaggcgg ccgccgcgga ccgccttgcg gccgccctcg
      301 cccgcctcaa cccggccgcc cggatcgtcc ccgcccggca cggccgggtc ccgctggccg
      361 aggtcctgga caccggccgg ttcgacctcg aacgcgccca acaggccccc ggctgggtgc
      421 gcgaactcaa cggcgaccac gtccccgaga ccgaggagta cggcatctcc agcaccgtct
      481 tccgggccga ccgccccttc cacccgggcc gcctctggca gttcgtcacc accgacatgg
      541 acggcggcgc ctacggcgac gtcctgcgct ccaagggctt cttccggctc gccacccggc
      601 ccggcgtcac cggcctgtgg tcccaggcgg gcgcggtcgc ccgcttcgag ccggccggga
      661 cgcacgccga caacgcctac gacgccgccg gctccgccga accgctcggc ccgtccggcc
      721 aggaactcgt cttcatcggc accgacctgc acccggcgcc cctgcacgcc gccctgaccg
      781 cctgcctcct cgcccccgac gagcccgtcc ccaccgcggc cgacgacccg ttcccggcct
      841 gggcggtgca cggccccacc gacgcctgcg cacacgacca cgaccacgac cacggccacg
      901 cggacgcgcc ggtggccacc gcggcgaggg gctagccggg gccgaccccg gcgcaccggc
      961 cggcggccgg cggccggccg tcacgggata cggtcgcgaa cgcggtgtcg gcccgcgaaa
     1021 agtttttcgg cgtgggcggc aaccccgccc ccggccgcac gtcgtctcgg gtgaaggcgc
     1081 ccccgggcgc caccgtcgac gaactggagc agccgaccgt gaacccgtcc cgtaccgccc
     1141 gtccctcccg cacgcgccgt gcggccggtg ccggcctcct ggccgctatg gcgctcgccg
     1201 ccgtctcgac gaccggcacc gcctacgccg cccccgcctc cgcactcgcc tcgggcccgg
     1261 ccgccagcgc cagcccgtcg cccgtcccca cccagccgcc cggccacggc agcggcccga
     1321 gcgccgaacc cacccagccg cccagccaca gcagcgcccc gagcgccgaa cccacctacc
     1381 ccccgggcca cagcgccacc ccgtccccgg tgccgccccg tggcaccgcc gccccctcac
     1441 cggtccccag ccagcccggc agccggccgg cccccggcaa ggacaccggt gacggccagc
     1501 agctcgccaa gaccggtgcc tcctccggca ccaccctcgc cctgggcgcc ggcgcggccg
     1561 ccctgatcgc ggtgggcggc ggcgcgctct acgtcgtccg ccggaaccgc gcctgaccga
     1621 ccgggtacgc ccgagggaac gatggcccac tacgcaccgc acccggcccc ggcaggattc
     1681 gccctgccgg ggctccggcg cgccgcctgg cgccgcctgc tgcgcgccgt ccgccgcgag
     1741 tcgccggccc gccactccgc atccgtccac caactccccg cttccgcacg gcagtcggcc
     1801 cacgcctggg acgacgcccc ggagccgcac cgtcccaccc tcaccgagct gtaccacgcc
     1861 caccggctga agatggtccg gctggcgatc ctcctcgtcg acgaccgcgc caccgccgag
     1921 gacgtcgtcc aggacgcctt cgccgccctc tacaaacgcc acggcgaaca gctcggcgag
     1981 gtcgacaacg ccctcgccta cctgcggacc acggtggtca acgccgcccg ctcggtgctg
     2041 cgccggcgcc gcaccgcccg cgagtacacc ccgccgcacg aggccgacgc gccgtccgcc
     2101 gacgaacggg tggtactcga cgaggagcac cgcgaggtcc tcgccgcgct cggcgccctc
     2161 accgcccgcc gccgcgaggt gctggtcctg cgctactggg gcgacctcac cgaagcgcag
     2221 atcgccacga ccctcggcat cagccgcggc gcggtgaagt ccctggccag ccgcgccctg
     2281 gacgccctgg agaagatcct ggaggaacgg tcttgagcac ccgcgacacc gccccctggg
     2341 acgccacggg cgaacgcccc gtcgaggacc ggctgcgccg cgccctcgcg gcccgcgccg
     2401 acgccgtcga cgtccacgac ctgcgcccgg cggcgccccc cggcccgcgc ccgggccgca
     2461 gccgcccgtc ctggctggcc ctgcgcaccg ccttccggcc gcgccgcctg gcgctgccgc
     2521 tggccgccgc ggcgaccgcc gccgtggtcg ccctcgccgc gcacctcgcc accacctccg
     2581 accgcgcccc ggcccctccg cagccggccg ccccgccgaa cccggccacg ccgtccccgc
     2641 gcggcgccac cccgaccccc gtcccgtccc cgtccgcccc gggccgctcc accgaacccg
     2701 gccgcggccc cctcggcacc gccccgggca ccccctcccg ccgtccgacg cccagcaccg
     2761 ccccgcccgt cccgaccagc tggccgtccg gccgcgccac cggcggcgcc accggtggtg
     2821 cggaacccag cggcctcccc acgcccgcca cgtccacgcc gtccgcgccc ccgtccacgg
     2881 ccaaggcgtc gcccggcgtt cgctgaccgg tccctgtccg ccccggcccc ccttccccga
     2941 gaatcgtgcc catgcccctc cggcccgcac cttcgccccc gaccacgtcc gggtgcaccg
     3001 gcgccgcccg ccgcgcccga cccctcgccg ccgccgtcct ggccgccgcg gccgccctcc
     3061 cgctcgccgc ctgtcagaac gccggcggcg aacgggacgc cgccggcccg cgcaccgtcg
     3121 ccgccccgtc gcccacggcc ggagcacacc cccgcgaccg gaacgcctgc acgcccgaca
     3181 tgctgcggtt ccacgccggc gcggagctgc accgggaccg ccgcatgctg ctgaccgtca
     3241 ccaacgtcgc ggaccgcacc tgcaccttcg ccgcgcagcc ctaccccctg ctgcacttcg
     3301 gcgaccggct ccccggcccg ctcccgcccc tgccgtacag cagaccgcgc accccggtcg
     3361 tcctcctacc cgacggcacc gcctacgccg aagtgctcac cgccgccgcg cccggcggac
     3421 cgggcggccg cagcgccccg gccagcacga ccgaaaaggc gtcccaattc ggcatcgccc
     3481 tgaccacccg caccaccccc acacaggtcg gcgtggacgg tcgcgccccg atccgggtgg
     3541 acccgggcac cgccgcggtc acctactggc agccgggccc accggccccg ggacggtggt
     3601 gatccggcca tgttccgggg cggctgccgg ccgtcgcgag cggacgagcg agcgatagcc
     3661 cgttcgtgcc gtatcagcca gctcatcacc caccaatgat ccatttttgc cgtgattgat
     3721 ctcctttgct ccgccccctc ctggctgcgc ccggtgcctc cggcccggta ggctttccgt
     3781 gtgatcttca agcgcatcgg aaatgggcgg ccgtaccccg accacggccg ggagagcacc
     3841 cgccagtggg cggacgtagc cccgcgcccg gtacgcctcg accagttggt gaccaccaag
     3901 cagcagctcg acctcgaaac gctgctcgcc gaggactcca cgttctacgg cgacctcttc
     3961 gcccacgtcg tgaagtggga gggcgacctc tacctggagg acggcctgca ccgcgcggtc
     4021 cgcgcggccc tccagcagcg ccaggtgctg cacgcccgcg tcctcgaact cgacaactga
     4081 cggtcggacg gcgcccgctg ggccgttcgg gcgtcagcac gggaacccgc cgcggcgcca
     4141 gccgaattgg cccactcggg tttccctcac acaacgcact gatcatctag taggcacggc
     4201 acacgcccgg gactacgctg cggccatgag catgctgacg cctccgggaa tgggcggtaa
     4261 gtaccgcatc acgggcgaca ggtacccgcg gatgcgccgc ccccgccacc gtcgccgcat
     4321 catcctcagc atcgtcgcca gcgcctgcgc cctcgggctg gtcggctggg gaactctgca
     4381 gctcatcgac gtcttcggcg gccggggcag cacggcccag gccgcgcagg acaccagacc
     4441 gtgcccggac ggcaccggcg gtcccgccaa ggccgccccg tcggccgcca aaccgcccgc
     4501 cccggcgtcc ctgaccgtca acgtctacaa cgcgaccccg cgctccggtc tcgccaagcg
     4561 gaccgccgac gaactccaaa agcgcggctt caagatcggc aaggtgggca acgccccggc
     4621 cgcctacgac aagaaggtgg ccggcaccgg catgctgctc ggccccgcga cggccaccgg
     4681 cggcgcgctg aaggtgctgg ccacccagct cgccggcgcc cagctgaaga ccgacgaccg
     4741 caagggcgcc gacctcgacc tgatcatcgg cggcgccttc aaggagctca ccgccccgca
     4801 gcaggccgcc aaggccctgg ccctgctgac ccgcccggcc caggcaccgg cccccgcgaa
     4861 gtgctgaacg ccgcggggcc ccgcaccact aggggtgcgg ggccccgcga ctaccggcgg
     4921 ctcagccgcg aaggacaggc tcagcccgcc gtgccgtaca tgcggtcgcc cgcgtcgccc
     4981 aggcccggca cgatgtagcg gtccgcgttg agctgctcgt cgacggcggc cgtgaccacc
     5041 gtgaccggcg tgccggccag ctcgcgctcc atgacctcga cgccctcggg cgcggcgagc
     5101 aggcagatcg cggtgacgtc gtccgccccg cgcttgatca gctccttgat cgccgcgacc
     5161 agcgtgccgc cggtggccag catcgggtcg acgacgtaca cctgccgccc cgacaggtcg
     5221 tcgggcatcc gcgtcgcgta ggtgtgcgcc tcgtaggtct cctcgttgcg caccatgccc
     5281 atgaagccga cctcggcggt gggcagcagc cggaccatgc cgtccagcat gcccagcccg
     5341 gcccgcagga tcggcacgac catggggcgg ggatgcgaca gccgcacgcc ggtggtcgcc
     5401 gtcaccggcg tctcgatgtc gacctgctcg gtgcgcacat cacgggtggc ctcgtaggcg
     5461 agcagggtga ccagctcgtc ggcgagccgc cggaaagtcg gggagtcggt gcgcttgtcg
     5521 cgcagagtgg tgagtttgtg cgccaccagc gggtggtcga cgacgtggat ccgcatacct
     5581 cgacactaac cgagccgcaa ggccccggcg cccgtcatat gccgcccgcg ctccggcacg
     5641 tgagcgacat ctctcacaac ctccgcacga cgcagcgtcg aagacaccgc gcggacggga
     5701 tgtttctgcc acgattccga aggggcggga agcagcggcg tgcagcgccg ccccgcccgg
     5761 cccggcacgc ctctaccagt gggagagtca cggtgtactt cgccgcactg ctcgcgcgca
     5821 ccgaagacgg gtgggaagcg agcgacacag agctcgacga tgtggaaacg ctgaccgatc
     5881 tgaccgacct ggcccgagaa gcagccgccg acgacacggt agtggtcctc atcgagcagg
     5941 aggacgcctg gttcggcgtc gtccggatcg acggcgagga cgacccgagg gtcttcgtct
     6001 ccaacgccgc gatggcggcc aggagctcgt acggcacgat gctgaccgac gagctgctcg
     6061 gccgcgacga cgacgcggac gacctcgacc tgctcgacct ggacggcacc gaggacggcg
     6121 aaccggaaac ggaggacgag gacccagagg accgggacgc cgacgaggca cccgtggccc
     6181 gcggcccgct cggcgacgcc cggctcctgg aggacgtcgg cgtcggagag cgggagctgt
     6241 tgaccctcga cggcgacgcg ctcgggtcga tcgccgaggc cctgggctgc tccgacctcc
     6301 tggaagccgt ccgctgaacc cgccgggccc tcgcaccgcc gggcccggca ccggccgcac
     6361 caccccgtcc ccgacactgg gggcatgacc gtccctccgt ccgcctccct tccctccccc
     6421 acgcccgacc cgctgcgcga cccctggacc gggccgatgc gccgggcgct ggcggaggcc
     6481 gcccgcgccc ccgggaccgg agacgtcccg gtgggcgccg tcgtgctgtc cgccgacggc
     6541 acggtcctgg gtaccggcca caacgaacgc gaggccaccg gcgaccccac cgcacacgcc
     6601 gaggtcctcg ccctgcgcgc cgccgcccgg accgtcgggc agtggcggct gaccggctgc
     6661 acactcctcg tcaccctcga accgtgcacg atgtgcgccg gcgcgatcgt gctctcccgc
     6721 gtcgaccggg tcgtctacgg cgcccgggac gccaaggccg gcgcggtcgg ctccctctgg
     6781 gacgtggtcc gcgaccgccg actcaaccac cgtcccgagg tcgtcaccgg tgtcctggaa
     6841 gcggactgcg cggccctcct gaccgccttc ttccgcgacc gctgaccgct gtgcgcccca
     6901 ctgaccgcaa tccgatttcg gcgcacgggg ccctgtgggc taagctctct ctcggtagcg
     6961 tgtccgagcg gccgaaggag ctcgcctcga aagcgagtgt ggcgcaagtc accgagggtt
     7021 caaatccctc cgctaccgcc agtaacaccc ccctgaactg cggaaacgca gatcaggggg
     7081 gtgttgtgcg tgagggccgc gtggtgatcg gtgctggggt gttgaggcgt ccccgcggca
     7141 gcccgtccca cccctccatc tccttcgagg ggcagcggag ttgccgctcg cggcgggaat
     7201 ctccgccggc ggaaccgagt tgcccgctgt gacagcgagg acgacggggg ccgcggtccc
     7261 cgcggggagg ggacgaggtc cgatgagcct tcgtcagttc gagtacgccc tggccgttgc
     7321 cgaggagggt tcggtgaccg cggcggcgga gcggctgcgt gtcgcccagc cctcggtgtc
     7381 ccagcagatc cgcggcctgg agcgggatct cggcgtggag ctgttcgcgc ggacgccgac
     7441 ggggctggtg ccgaccgtgg tcggccgcgc gttcctgcgg gacgcgcagg ccgcggtgaa
     7501 cgcggcgcgg cgggcgcggg cgacggcgcg ggccggtgcc gaggagctgg tgggcgagct
     7561 ggtggtcacg gtgcagatgg gcttcggcac ccggcagctg ccgggtgccc tgggcgcact
     7621 gcgtcgccgc ttcccgcggg tggaggtcac cgtcttcgag gagccgagct ccgccgagat
     7681 ggatcggctg tgccgccggg gcgcgctgga cctcgccctg atggcgaagt gcgagcggac
     7741 ccccgccaac gcccaccacc tcggcgacga ggagttcgtg gtggtgctgg gcgccggtca
     7801 cccgcagctc gccgcggagc gggtcgagct gcgggagctg gcgggtgagc cgtgggtgcg
     7861 gttcgaccgt gacagcgccc tcgacggcgt gctgctggag gtactgcggg acaacgggcc
     7921 gaccccgacc acggccgccc gcgtttccca gacggcgacg gccgtgcgct gggccgccca
     7981 cgggatgggg gcgacgctcg tcccggcctc cgcggtgccc agcggtcacg agcacctcgt
     8041 gcgtccggtg ttcccggcgg tgtcccagcc cgtgatcgcc gtggtccggc ccgtcgcggg
     8101 cccggcggag acggccctgc tcgaactcct gcgtcaggag acctggtccg agcccgtggc
     8161 acaacggtag gacgggctca gagctgggtg gcgccgccgt ccacgacgag ttcggcgccg
     8221 gcggtgtacg tggcgtcgaa ggcgaggaac gcggccgccc cggcgatctc ctcgggggtg
     8281 ccgaagcgcc gcatgggatt gcccgcgacc tgctgcgcct tgaactgctc ggcggcctcc
     8341 ggggtcagcg tgccctccag gaccccggtg tcgacggggc cgggactgac cgcgttgacg
     8401 cggatccccc gcggcagcag ttcgcgggag aggctgcggg ccatcgagcg cagggccgcc
     8461 ttgccggccg cgtagacgct ggtctccggc acgccgagga cgttcgcgac cgaggtggtg
     8521 aggacgacgc cggcgcccgt gttcagcagc ggggcgagct tctgcacgct gaagtaggcg
     8581 cccttgacgt tgatcgcgaa cagctcgtcg tacgccttct ccgtcgtcga ggcgaagggc
     8641 gtgagggtgg cgatgccggc gttgacgaac agggcgtcga gtgtgccgag ttcgccccgc
     8701 acccggtcgg ccagcgcgtc caggtccggg agcgcggcca cgtcgccccg gacggccacc
     8761 gcgtgcgggc caaggtgctc cagcgccgcg tcgagggtgg tccgggagcg accggtgatc
     8821 accacgcggg ccccctcgtc cacgagcagc ttcgccgtcg cgagccctat gccgctgcca
     8881 ccgcccgtga tcactgcgtt cttgccgctg tacttgccca tgactggatt ccttctgctt
     8941 tctcgtgagc gcgggctgcg atcaactcgc gcccgtgtat tccctttttt cgaaaacggc
     9001 gttccggaat tccgccggtg tcatccccgg gggaattcgc cgccgtccac gacgaggttg
     9061 ctcccggtca gccagcccgc ccggtcggag acgaggaaca gcaccgcgtc ggcgatgtcg
     9121 tcgggccggc cgtcgcgccc caacggtggg gcgtcggcgg cgttggtctg gcccggcgcc
     9181 gcgttcaggc gcgcccactc ctcccgcgtc gcctcgccgc cgggggtggc ggtccggccg
     9241 ggggacacgg tgttgacccg gattccgaac ggggccagct ccaaggacag gccccggctg
     9301 tagttctcca gcgccgcctt cgccgtcgtg tagtgcagga actggcccac cggggtgcgg
     9361 accgcggccg aggagacgtg cacgatcgcc cccgaacgcc gttcccgcat ccccggcgcc
     9421 agcagcgcgt ccagccgcac cgacgacagg aagttcaggt ccagcgccgc ctgccactcc
     9481 tcgtcgggga tggccgaggc gcccgcgtgc gggcgtgccc cgcccgcgtt gtggacgacg
     9541 acgtccaccc cgccgagcgt ctcctgcgcg gcggcggcga gcgcctccgc gccggcccgc
     9601 gtctgcacgt cggccgccac gaaggcggct ccctgcggca cggtgtccgg cgccgtcctg
     9661 gcggtcgtga gcacctcggc gcccgcggcc aggagttggc gcaccacggc ggcgccgatg
     9721 ccgcgggtgc cgcccgtgac tagcgcccgc tttcctgcga gttcgcgcgt tccccgtccg
     9781 gtttcgctcg tggtcatgcc accgttcctt ttcgctagcg tgcggatctg ctcgacggaa
     9841 aggagaagcg acgtgcgccg ggcgcgattc ttcgaaagaa gtcgcggtgc gcacctcgtc
     9901 gagccgtttc acggtagatc cggaaaagaa cgcgaggcaa agaccaaatt ccagcgggcg
     9961 ccatagggga ttcctatggc gcccgggaac tgactgggcg tcagagatcc agaggggtga
    10021 cgtcgggggc cgccaggggg ctcgtgggga ggccgagggc catgttgccg acgtggctga
    10081 ggtgggcgcg cagggacggg ggcaggaacg gggcggtgaa cggggcctcc atgcggccgg
    10141 tgaggcagga ggccaggccc aggtcggtgg cggtcagcga gagggtctgc atcaggcagc
    10201 cggtgtcgcg gtagatcagg ctgagggcca tcccctcgta cttccaggtg gtgcgcgccg
    10261 ccacggcggt caggcagagg ctggccgggg gcgcgtggtc cagcagtgcg gggtcggtga
    10321 cggtgcgctg ctggaaggcg gccaggtcgt cggtccaggg ggcgagccgg tgcagggcgt
    10381 gggcgaacgg atcgtagtgg taggcgccgg gggccagtcc ggcgaccgcc cgggccacca
    10441 ggtggacctc caggctgtgg cgggcgccgc cggacggggc cgggcgctgg gtctgctggt
    10501 aggcccgcgg cgccaggtgg ccgcggaccc gcgcggcgcg ggccagcagg gcggcgagga
    10561 gcggcagcgg cacggggtcg ggggcgtagc cgcggacgct gcggcgcgcg gccaggacgt
    10621 cgaccagcgg acggctgggg gcgccggcgc cgtcgggaag ggcgatcacc gcgtcgacgc
    10681 cggggtggtg gaggcgggcc ggcggcgggg tgccgcggcc ggccgcggcg tccgggccga
    10741 ggcccgagcg ggcgtgcacg gcgcgctcgt acgcggtcca gccggctccg gggtccttcg
    10801 cggcgtcctc ggcgtcctcg gcgtcttcgg cgacgtccgt cgggggcggg gcgcagcggc
    10861 ggaggatgcc ggccgcggcg agccggtcca gcagcgtgcg gacgtcgccg cccgtggcgg
    10921 actcccgcca gcggtcctgg agttggtcgg cggtgcgcgg gcggtcgagg tggttgagca
    10981 ggtcgacgag gacgggcttg gcggcgaact tccgccagct gccgcagtcg acgaggaccg
    11041 ggccgccgcc gtccgcccac tccagcagca ggtcggggtt gcggcggtag gggcgggcgt
    11101 cgtggtcggg ggcgccgttc ggggcgcccg gtgcgtcgtg ggccgtggtg tcgtccatgc
    11161 ggtggtccgg gccctccggc gggtcgtcgg cggtcgtcgg cggtcggtgg gaagggaggt
    11221 cggcgggtgt cacaggaacg gcagcggcca ggggttgagt tggtcctccg tcagcgcggt
    11281 ggcgcgcact cccatcgcga ccggggcctg gcggacgcgg gggccgccgc gccggtggaa
    11341 gtcgctgcgc agggtgagcg ggcacaggcc cgggaccacc gtgcggacca cgctgacgcc
    11401 gcattcggcg acgtcgatgg gggtcaggtc gacggcgatc gcctcgtggc cgcgggcggc
    11461 gagccggcgg acggcctcgg cgacgtcgtc ctggaggctg ccggccggcc gggccgcggg
    11521 cagcgggtgc agcggcccgt ccgcccagaa ggccaggtgg tgctggcggt cgggcgcgca
    11581 gtagtagagg cagaactcgc tcaggctgct caacgcggcg tcggccgccg gaacttcgcc
    11641 ctcttcgagc cagatgccgg cgccggtccg gcacaggcac gcctcctcca gcgcgcccag
    11701 cagcgcggtg tgcgggtcga ggtcggcgcg cgcggcgtgc accacgaccg gccgctcggc
    11761 ggtgcccccg gcgaaccgca ccgcgacggc cgggatgccc aggtcggtgg tgaggtcctt
    11821 gcaggtgacc gtcgcgccct cggcggtgat ccggtccacg atgcgccggg cgggcccgtc
    11881 gggcaggccg gtcaggtcga ggccgggcag ggtcagccgg ttctcccaga agaccagggt
    11941 ggcgtcgcgt tcgacgctct ccatcaggcc gccgaggacg gcgtggtggt acgagccgcc
    12001 ggcggcgagc ccggtggaga tcgggtcgaa ccacggcttg tgggcgcgcg ggaagcggta
    12061 gggcaggtag acggcgcagg ccgggacgta ccgcgggcgg ccggtggcca gggacgtccc
    12121 cgccacccag tcgatcggca cggcggggtc gaagggggcg tagcggcgct gggcggcgta
    12181 ctcctggtcg gagcccagcg gcaggctgcg cgggtcgatt gcggcgtcgc cgagttccgc
    12241 gagggtggcg cggaccagcc ggtcggggtc gtacaccccg gccgcgtacc gctccatggt
    12301 ctcgcccacc gcgcagaccc gggcgttgac cgggtcgctc ttgaccgcgc cgccgcgggc
    12361 ttcggcggcc accggggaca accacgtggt ggtggtcatg ccggcggtgc gcgcataggt
    12421 ggtgccgtcg gggccgctcg gctcgtccac ccggagttcg ggcaccagcc cggtcagcgg
    12481 gtcgaccgcg ccgcgcatca gccgccagct ctccgcgacg tccacggcgg ccgtcccgtc
    12541 ccgtttgggg ggcacggcgg cgctcgcgca cgcggggcag ccgggggtgt ggaacagggc
    12601 gtgcccggtg cgctcccagg tggcgtggtc gagttcggtc agctccgggg gcccggtggg
    12661 cgcctcgggg gcggcgaggg cggtgagcac cgcgtgggcc accgcgccgg ccgcgacggc
    12721 ggtggtcggc cacgcctcgc tctgtgccgc gcccagcagc aggtccagcg gcagtccggc
    12781 caccggctgc caggtgtggt tggcccggat ccgccgcacg aggcagaccg ggcagggcgt
    12841 gtgcggggga ctgagggtgg cgagcagcag ccgggtgggg gtgctgaggt acgtcacgag
    12901 cggtgtcccg tggtccagca ccagggtggt gcggcggcgg agttcgtctt cgggcaggcc
    12961 caacgggagg accaccgcgg cgggttggtc ggtggtgtcg gccggtgcgg tccgtgcccc
    13021 ggccctttcg aggagggcga ccacgtcggt ggccaacggg ccgtctccca cgaccacgac
    13081 cggccggcgc ccgcgttcgg cgccggtccc gtagagcggg tgcggcagcc ggccgtctcc
    13141 ggggtgggcc aggccgcggg cgtgcaggcc ctcggccacc cgctcgggca ccgcgtcgag
    13201 ggtgaccgtc cggtggtccg cgtcgtcggt cggcaggtgg acggggaccc gcagggtgcc
    13261 ggtgctcgcg cagacgtaga ggtgccggcc gctgctgacg agccggacgt cgcggcggag
    13321 ggtgagcggg gcggggggcc ggggggtttc caatgctgtc cgccttcggg agccgtgggg
    13381 tgggggcgcg agaagtgcct cccggccggt ccttccgccg gccgggaggc acgtctcgcc
    13441 gttactccgc cgactccgtg tcgtcgtatt cggtgacgaa acaaagacag ctgtggccgg
    13501 cgaaggccgt ctccgactcc ggaatgacca tctcctcgaa caggtcgtct tcctcggcca
    13561 tgacgattcc cctttccgtg gatttctcaa ttaccccacg agtcacaccc gccaacactc
    13621 cgggtgagcg ctcgacaact attgctgcgg acccgggtaa tccccgtcaa gaaaaaccga
    13681 tgaaatgact cgattcccca ttagtacgat agtgcgacgc atttctttgc gctttacata
    13741 cgcccctgag ctggcacttc tcccgacggc gcggccgctc acggagacct caggaagcgc
    13801 aagcgcgcga accggccgcc agccggcggc gccccgtttt cagtcactca ggaatccccg
    13861 ggaaaatcgc acggaaaacg aaaacggggg cggtcggagt ccgttgtgga ctccgaccgc
    13921 ccccgcagtg cgcggacggc gcagaaggaa ttgacgtgat ccgtcagtcc cggcggcgga
    13981 aagccttccg gatgaagtgc acgatcagcc agatcaacag gatcacgatg acgatgatgg
    14041 ccacgacgat cacgatcagg aagacaccga gcttcttgaa gaagcccatc ttctttttct
    14101 tcggcttgtc gtgggacgtg aaggacgcct ggtgcgtcac ctggcggtgg ctgctgtgcg
    14161 tgctgtgccg ccacttcgcg ggggccgcgg cggccgcctc gacgcgctcg gcgtcgacgg
    14221 cggtcgtccg ggcacccgac gcggcgtgcg gggcggccac ggcggcgggg cgggccgcgg
    14281 cggcgtcgga cagtccggcg gcggccgcgg ggccggcagc ggcggccacc atgccgaaca
    14341 gcagcgccag caccaccatc gggcggcgcc cccaggtccg gcggacgggt gcgtgcggcg
    14401 aaccggactg ccggtgcgcg gagttcgtgt gcttcggtcg catgggttgc tttccccctc
    14461 gtacggtgcg ttcagccatt atgggcggac gcgggcgcgg acaccccggc ggacgtctcg
    14521 acctccatca aggaggcgct gtgccgctcc tcgtcgaagg ccgcgcgacc gccccgcagg
    14581 ccgaacagcc gcttggcgac cgcgatgtag agcaccgcga ggatgttgac gaccagggtg
    14641 gcgatcttga gccagctgac cttctcggtc agctcgtaga tctccagggg caggaacgcc
    14701 gcggtcgcca ccaccgccag gtactccgcc cagcgctggg acaaccacag gcccaccccc
    14761 tcgacgatct ccaccagggc gtacgccagc aggagcccgg ccaccagcag cagggtggag
    14821 tgctggtagc cgaaggtctt ccggatggtg tcgacgaccg gggagtggtc caggtcgtag
    14881 tggaagtgca cggcgatcgg acggaccacg tccaggttct tgtcgaagaa ctggcgtacc
    14941 gcgtcctggc tgttgctgaa ctgccagacg gcgagcgccg ccagcacgac gaacagcccg
    15001 cgcagcgccc gctcgacggc caggaaccgc aggatgaaca ggtcccgcag cgccttcccg
    15061 cgcggcacca gcggggcgtc gcaggccggc ccggagccgt gtggctcgcc cagcacgaag
    15121 tccccgcagc gcaggcaccg ccaggccgtg cccagggcgg tgccggcgtg cagtctctct
    15181 tggaggtgcg tctcgtccgg gaggtaggtg atgtgtccgc gccgcgcaca ggtgcgccgg
    15241 ttccagtcga tcttcaccgt tggagccccg tgttcctctc gtcgtcccgc gcgggccctc
    15301 gtgccgcggc ggtcggccgc cgcggcgcgg gtccgcgctc cgtgccgggc gattgtcgcg
    15361 tacatgcggg aatcgccggc gtacggggat gccttacgga cagagggacg agaagaacgg
    15421 tcctgaggtt gccgggacga cggtccggac tggtgcgcgc gcccggcgca cggggcgcgg
    15481 gggcgttggc cgggggaggc gggccagggg gttggatccg cctcccccga tgaggaccgg
    15541 ccccgatgtc cacgccgcac cgtcagggaa cgcgcgacgc ggaccccgca gtggggcact
    15601 gatcccgggg cccctgcgga ttcctgccag acccgccgtg acccgtgcct ccatcctgcc
    15661 gcccgcgggc cacccaacag ccgggcgaag gacccccctt ggtgggcctt tggtccataa
    15721 gacccgcgtg aagggcaggg ccggacggcc cgcaccgcct gccccgctcg aacacctgtg
    15781 gttacactcg cccgaccgca ccggcaaccg gagcggccac gggggccagg gggcccacgc
    15841 ggaacgccgt aggggcgcag ggtcccgccg caggggagac ggaactgatg gcgacagcga
    15901 agaaagtggc gttgtacctg gtcgtcatct tcgtgctctg gacgatcatc gccaccccca
    15961 agcgtgccgc cgggctggtc cagataggct tcgaaggcat ctcgaccgcc gcgcagagcg
    16021 tcggccagtt catgacccag ctggtcagct aggtcccagt cggcccgccg gaccggctgc
    16081 gcatcgtccc gccgcacgga ggccacccgt gatccgccac ctggtcctgt tcaagctcaa
    16141 cgagggcgtc tcgcgcgacg aggagcgtgt gcaggccggc gtccgcgcct tcgccgcgct
    16201 ggagacggag atcccggagc tgacgttctg ggagtgcgcc tggaacatca ccgaccggcc
    16261 gatcgcctac gacttcgcga tcaactcggc cgtcgccgac accgacgccc tcaagcgcta
    16321 catcgagcac ccggcccacc aggcggccgc cgcccagtgg cgcgaattcg ccacctgggt
    16381 gatcgccgac tacgagttct gaccccggcc ggcgccaccg cgccgccgcc ggcgtcccgg
    16441 ccccccgccc gcccggacgg ggggcttcgc catgctcccg ggccccccac cgcacccccg
    16501 tcgcgcgcaa cccgcgcgtg acccgcgcgc gacgccaact ctctcttcaa cacggcgtta
    16561 tggggtgctt gcacacagtg cacatgtctt gtgatgctat gaccgctttt gccggataca
    16621 tgcgatacgc gatacatgct gcgatacatg cactgtgaag ggtggcgtga ccgtgacggc
    16681 ccgtactgcg cccaaggctc cggcccgcga gagccgtagc gcggacaccc gggcgctgac
    16741 gcaggtgctc ttcgcggagc tggcgggcct gacacccggc acccccgagc actcccgcgt
    16801 ccgtgccgca ctgatcgagg ccaacctccc gctggtccgc tacgccgcgg cccgcttccg
    16861 cagccgcaac gaacccatgg aggacgtgat ccaggtcggc accatcggcc tgatcaacgc
    16921 catcgaccgg ttcgacccgg agcgcggcgt acagttcccc accttcgcga tgcccaccgt
    16981 cgtcggcgag atcaagcgct acttccggga caacgtccgc accgtccacg tcccgcgccg
    17041 cctgcacgag ctgtgggtcc aggtcaacgg cgccaccgag gacctcacgg tgctgcacgg
    17101 ccgctccccc accaccgccg agatcgccga gcggctgaag atcggcgagg acgaggtgct
    17161 ggcctgtctg gaggcgggcc gttcgtacca cgccacatcg ctggaggccg cccaggaggg
    17221 cgacgggctg cccggcctgc tggaccgcct cggctacgag gaccccgaac tggccggcgt
    17281 cgagcaccgg gacctcgtgc ggcacctcct cgtccagctc ccggagcgcg agcagcgcat
    17341 cctcctgctt cgttactaca gcaatctgac gcagtcccag atcagtgcgg aactcggggt
    17401 ttcgcagatg cacgtgtccc ggctactgtc gcggagcttc gcccgactgc gatccgcaaa
    17461 caggatcgac gcctaaccgg cacgggcgac ccgctcctgc acggatatgt cgacaagacg
    17521 ctacagcgcg ttgccgacat gtgacattct gctggaaccg cgtttgccgt ggtgctgcct
    17581 ccggtattca ggtggaggca taactcctcg gtccgccctg ggccgaggac gccgcagcga
    17641 cccgtccgcg acctcaaggg ggtggcatgt ccgtagaact gggcagctcg aaggtgcttc
    17701 ccgcgattcc cgcgccggca ccacacgtgc atgacgacgt cgacgccatc aacacccgct
    17761 cgctctcccg gtccctgttc ctgcggctcg ccacgctcga caaggactcc gccgagcgcg
    17821 cgtatgtgcg cgacacactc atcgaactca acctcccgct cgtgcgttac gcggccgcgc
    17881 gcttccgcag ccgcaacgag ccgatggagg acatcgtcca ggtcggcacc atcggtctga
    17941 tcaaggccat cgaccgtttc gactgcgaac gcggggtgga attcccgacg ttcgcgatgc
    18001 cgaccgtggt cggcgagatc aagcgtttct tccgcgacac gtcgtggtcc gtgcgcgtcc
    18061 cgcgtcgcct ccaggagctc cgcctggccc tcaccaaggc cagcgacgag ctctcccaga
    18121 agctggaccg ctcgcccacg gtgcccgaac tcgccgtgtg cctgggggtg tcggaggagg
    18181 acgtcgtcga cggcctggcg gtgggcaacg cctacaccgc ctcctcgctc gactccccct
    18241 cgcccgagga cgacggcggc gagggctccc tggcggaccg cctcggctac gaggacagcg
    18301 cactggaggg cgtggagtac cgcgagtccc tcaagccgct gctggccaaa ctcccgcccc
    18361 gggagcgcca gatcatcatg ctgcggttct tcgccaacat gacgcagtcc cagatcggcg
    18421 aggaggtcgg catctcccag atgcacgtct cccggctgct cacccgcacg ctggcgcaac
    18481 tccgggaagg tctgatctcg gactgaggca cggtccgccg aggggcatcg gcgagcgccg
    18541 atccggtcgc tcggcggaca gcaaccaaga cgacggcgcg ccaccgcgcg acgcccgact
    18601 ccgcctccac cggccgcgtg ccgtgactcc cgtgacgccc ccaccccttc ggccccacgc
    18661 cgacccttcg cgcggcgcag ccctgcgctc cgccgccctt ctcttctgat ggttcgtcag
    18721 caacactgtg cccagctacc gctgggaggt gtccgcacca tgcgacggac cacgcctgtt
    18781 gcctacgttg ccaccgcctc ggcggccgtg ttctgcctgg gcggcgtcct caccggctgc
    18841 ggcagcgcgg ccggatccgg ctacgccgca gtgggcgcag caggccccgc cgacccgagc
    18901 gcacccacga gacccgcgcc cccacggggc ggcgtcgaac tggcgcccct ggaaggcggc
    18961 ggcgccaccg gcccatccac ctctcccggc tccccgggct cttccggccc ttccggccct
    19021 tcccgcccga ccgcaccgga caccaccggc accaccccgc ccggcacacc cggcgcgtcc
    19081 gacggctccg gcacccagcc ctccgccccg cccggctcaa cgacgggtca gggcggcaac
    19141 cctcccggca ccaaaccccc tgcccctcca ggcggttcac ccgcacccgg acccggcggt
    19201 tccaccaccc ccgagccgcc ctcccccacc atcccggccg gccccaacgc cccgtccggc
    19261 ctggtcgtcg gcaaacccgt gctcgcggac accgacgtcc gctggtgcca gcgggtcacc
    19321 atcgacttcc tcaacaccgg ccaacacccg gtcaccgcag gcaccgtcac cttcggcagc
    19381 cacgtcatcg gcgccctcgg catcgactgg gccaccctcg actccacccg cgacctccca
    19441 ctccccctgt cccccggaaa accggcgacc ggcacctggc gggtctgcgt ggacgcctgg
    19501 cgcgtaccgc tcggcatgca cctggacacc aaggacgtca cgttcaagtg gaaatgagcg
    19561 ggcggcggtt cacgacatac gacggccggc cggccaccgt tacgcccgca cgtcgtattc
    19621 gaggacggcg gagcgggccg cactacggcg cggcgggctc gccgcgtccg gctgacaacc
    19681 gcacctcgtg tcgcgtcccc cggccttcgg cccagacacg cagtcgaagc cggtcgatgt
    19741 cggggcgatc ggcggccacg tactgcccgt acgcccgggc gacctcgtcc cacagcttcc
    19801 tgacgccgta ctgcgccacc gcgaaggtcg acgtctgccg gccgtcgtag tccacgctgg
    19861 cccagctcgt ggcctggtca tccgccaacc acagccgggt gtgcgcccct tccacctccg
    19921 tgtcccagga atgccacgct ccgggcacgt gcaggcccat gtagatctgc gcatcgagat
    19981 cgtctccggc cactgaccag ggggagaggc gggtcgtgga ccgttcgggg tgctgtccgt
    20041 cgcgcagtac gtcacgacgg agttcgacat gggtctgctg ggcccgcatc agcatgaagg
    20101 aaccgtaggg agcgagggcg ccctcggccg taccgtctgc ctgcttggtg gcgacgaggg
    20161 tgccgtagtt gcaccatgcg gtgtcccacg gggtgacgat gcggccgcct gccgcgacct
    20221 gttccaacca ggggagcggc acagtccgga cggcgcaggt ggagatgatc gcgtcgtacg
    20281 gggcggtcgg ccgccagccc gccgccccat cggcgcaacg cacctccggc cgctggccac
    20341 tcgccttcag cccctgctcg gcccggcgga ccagcacggg atcgacgtcg atcgaggtca
    20401 cgttctcggc gccgaagagg tacgagagca gtgccgcgtt gaagccggtg ccggtgccga
    20461 tctccagtac gcgcagcccc cgttggtcgt cgagggccat gagcatgcgc gccacgacgc
    20521 tgggcatcga ggccgaggag gagggaacca ggtctccgtc ggacagttcg gtgaactgcg
    20581 tgacgagaga ggcatcgcgg taggccgcgc gccaccaccg atcaggctcc cgctcacgct
    20641 cgcacggctc gtagccgccg ctcccgtccc gcagccacag cgtgggcgga aggaagagat
    20701 gtcggggtac ggcgcggaag gccgcccgta gtcgtgcggg gacgggcgcg cccaggcggt
    20761 cggtcatctg ctccagcaga tcaccgaccg ccacgtcgag cgctgaggat ggaggggaaa
    20821 ccaacggacc tacttcggct ggggcggtgg agtgggctcc ggaggaatgg gccgacccgg
    20881 ctgctgaccg tcgtctccga tcggggagcg gtgcttgccc acggtgcgcc tccttcgtca
    20941 gacgtcagat gaagcgtagg gacctcgccg aacagtgcgt aagggcgtag cagggcgtgg
    21001 gggcgcggaa ggggcgcatc ggacacccga accgtgcctt cgccgccggc acggaattcc
    21061 ccacccgaat ggcgatgagt ccggcacccc gcgacggtcg atacagagga cggcccccgg
    21121 gccgccgatc aaccgatcac cgtcagcggc cgtccggccc gtcaccagga gcgcgtcatg
    21181 ccgaagatca cccccaacct ctggttcgac acccagggca tggaggccgc cgagttctac
    21241 tgctcggtct tcccgaactc gaagatcaag aacgtcacgc actacacgga gggcagtccg
    21301 ggtacgcccg gcacggtgct gaccgtcgag ttcgagctgg acggccggga gttcaccgcg
    21361 ctcaacggcg gaccgcagtt caccttcgac gaggccatct ccttcgccgt cacctgcgcc
    21421 gaccaggagg agatcgacca ctactggacc aagctctccg agggcggcga ggagggcccc
    21481 tgcggctggc tgaaggacaa gtacgggctg tcctggcagg tcgtcccgga cgggatggcc
    21541 gacatcctga acgaccccga ccgggcccga gcggcccgcg cgatgcaggc cgtgatgggc
    21601 atgaagaagc tggatatcgc cgccatcagg gcggcggccg acgggaaggg gtgagccgcc
    21661 tggcggctac acggcaacgg cccctggctg acgaattcca ggggctctcc gccccgcggg
    21721 agcgccggaa ctacttctcc acccacacgt gctgtccgtc gtcatcgacg gtcagaccga
    21781 ggcggccgag accagggcgg ccctgcccct gccaccagcc gtaagcggcc tcgacctcgt
    21841 cccagagccg ccggtcaccg tgctggtaga ccgtagactc cggcctgtcc tcccggaaca
    21901 ggacgcacgc ccaggagcgg tcatcggtca aactgcacag ccacaccgga cgttggccct
    21961 cctgcggctc gtcgaggatg acagtgcagt cggggacgag caggccgagg acaaaccggc
    22021 tgatgtccca ttcaccggcg atcgtctcgt cccacgtgag tgtcgtggcg ccgcgctccg
    22081 ccttgtcccg ggactcggcg gtcacgtagt ccgcgtactg cggcacttca cgacgctggg
    22141 cccgaagact catgaactgc accaggtcct tgaacgtccc gctggcgctc cggccgtccg
    22201 ccgcgaccgt gagcgcgacc gtggcttccg tggacgtgaa gcgggtgccc cacggcacca
    22261 cgatcacgcc gccagggcga cactgctccc gccaggcgcg agggaaggtg tgcaccccgc
    22321 aggtggcgat gatcctgtcg tacggcgcgc ggggcgggta cccctggaag ccatcgccgc
    22381 agacgaccgt gactgcctcc agcccctgcc gttccagagc gcctcgggcc gtttcggcga
    22441 cggacgagtc gacctccacc gtggtcacgt tctcggcacc gaggcgggat gcgaggagag
    22501 cggcgttcca gcccgtcccc gtgccgatct ccagcacccg ttgcccggaa cgcacggtga
    22561 ggtcgcgcag catcgcggcg acgacggacg gcgccgaagc cgacgacgac gccacccggc
    22621 ccctccccgg gccttcgtgt tccccgtcgt cccactgcgt caccagggga tggatggaac
    22681 cggccgcctc gcaccatcgc tgcggatcac gcctgcggtc gacggcttcg acttctccag
    22741 tcgccacatg gtgctgccag aagacatccg ggaggaaccc ggcccggggc aggccctcga
    22801 acaccggctc ccattcggcg gtcagcgctc cgtccgccac gagccgcgca gccattcctc
    22861 gccactgccc gctcacttgc cgcgtttccc gccgcccttg ggcgcgccgc cgtcggtctg
    22921 cggcggttcc ttgggcgggg tccacggctg cccgggcagt ttgtcgggct taccgctgtc
    22981 atcaggcttg tcgcgcttgc ccatagtccc tcctacgttc gcccctatgg gacagatcac
    23041 gctagtggac ggctgatggc ggagtgaaga gcgcgctgac ggggtgcacg gtgccttctg
    23101 cgccgcgcgg gcggcggccg acgggaaggg gtgagccgcc tggcggtgac acggtaacgg
    23161 cccccggaat tcgccgtttt gggggccgtt cgcttcggtg gcaggtggcc gccctgccca
    23221 gctggctgtg aaatccccac ttctggcgac gggaacgagg ggccgtcggc ggcacaccga
    23281 gaagatgacg ggcgccactg aacgctgctg cgaaggcggc cacgtccgtc acctgcgaac
    23341 ggcccgtagg acg
//
