LOCUS       NZ_CP119144            20981 bp    DNA     linear   CON 22-NOV-2023
DEFINITION  Streptomyces noursei strain C27 chromosome, complete genome.
ACCESSION   NZ_CP119144
VERSION     NZ_CP119144.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces noursei
  ORGANISM  Streptomyces noursei
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 9627936)
  AUTHORS   Go,B. and Lu,Y.
  TITLE     Control effect and mechanism of Streptomyces NK27 against gray mold
            of grape
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 9627936)
  AUTHORS   Go,B. and Lu,Y.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-FEB-2023) State Key Laboratory for Biology of Plant
            Diseases and Insect Pests, Institute of Plant Protection, Chinese
            Academy of Agricultural Sciences, Yuanmingyuan, Beijing 100193,
            China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 01-OCT-2021
            Assembly Method                   :: ABySS v. 2.3
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 98x
            Sequencing Technology             :: Complete Genomics
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 11/22/2023 14:00:30
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,442
            CDSs (total)                      :: 8,348
            Genes (coding)                    :: 8,203
            CDSs (with protein)               :: 8,203
            Genes (RNA)                       :: 94
            rRNAs                             :: 7, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 145
            CDSs (without protein)            :: 145
            Pseudo Genes (ambiguous residues) :: 0 of 145
            Pseudo Genes (frameshifted)       :: 46 of 145
            Pseudo Genes (incomplete)         :: 121 of 145
            Pseudo Genes (internal stop)      :: 12 of 145
            Pseudo Genes (multiple problems)  :: 30 of 145
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 16:17:19
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 2121849
            Orig. end                         :: 2142830
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP119144.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..20981
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="17"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..20981
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..20981
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:10981](-)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..10981)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            696..2819
                     /locus_tag="P0D74_RS09395"
     CDS             696..2819
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="P0D74_RS09395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="integrase"
                     /protein_id="WP_275462296.1"
                     /transl_table=11
                     /translation="MNLIAIAGTDPLPGPDTPVFGPQVLTEGYAGPVIRYGDDIWPLSP
                     MNSNPSADAHAIHWSGFPTGLREEFRLIAWTMINGSLSASFVRARATAWRNRTSAPTIY
                     QTVWLWRRMATWMHEQGLDTLRSCGSTTLEKYASWLLETGATRSRVHKVLITLTRLWAF
                     DALGPHPLGVGRPPWDVHGVDDYLPPATTAQTGENLTEELSPETMGPLLIWAIRLVDDF
                     AEDILAADAERRSLRSATLANVGTPDTLTALRSYIDRRLAADQPLPTHVHAGRRCLNTH
                     YVAGTTGASLDQVHRRLGTPSWKQAVTRRPGPCPLSIRITGAIDGQPWRAAIDFNETLD
                     LMRHLTAACFIIIAYLTGMRPGEVLGLRSGCCPDPVPDENGRLPQHKVYGHVYKTARDD
                     GGNHVSAGVVREAPWVAIAPVVHAVRVLERLVPSGALLFDHRAHYLGKGTVQNGDGSLR
                     ISTIRGRIEEFIVWANAEASALGRAHEVIPPDPHGSIGTERFRRTLAWHIARRPGGLVA
                     LAIQYGHLRTTISAGYASCSRDGIHKLLNVETARATIDTITDLQDDLDNGIGVSGPAAR
                     RAINAAATAPQFQGTIVTARTARKILNNPALAVYDNPNTLLMCVYNRDRALCHRDTDNE
                     SPSLDRCVSACANIARSDHHADQLRERATALDTRASRLPGPIGDRLRGNAAKCREIADD
                     HDRTRIVLPETAP"
     gene            2816..3232
                     /locus_tag="P0D74_RS09400"
     CDS             2816..3232
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018845035.1"
                     /locus_tag="P0D74_RS09400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_275462297.1"
                     /transl_table=11
                     /translation="MTPALDERKRIRAAMDRILAGTPERSNGALTIVALATEAGVPRNA
                     LTQRHLDLKAEFYDKVRARGEMPDSEKRLRQQIVKLKELREADKAAITRLQTDLEAVVR
                     VVHQLTVENRQLRTELTTPDARVRVLPTQPRPTD"
     gene            <3328..4392
                     /locus_tag="P0D74_RS09405"
                     /pseudo=""
     CDS             <3328..4392
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015662333.1"
                     /locus_tag="P0D74_RS09405"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="DNA cytosine methyltransferase"
                     /pseudo=""
                     /transl_table=11
                     /translation="PPCQAWSMAGKRLGLLDQPLVHQAVADLAIGRDTRELLLAACRDE
                     RSLLAAEPMRYLHALNQHGQPEWVAMEEVPDVLPLWRQYAAILRSWGFSVWTGILNAAD
                     YGVPQTRRRAILLASRTRTAEPPQPTHAKAAEPESLFGPGRAQWVSMAEALGWGATDRP
                     VPTVCAGGGPGGGPEPFPSGSRKTLTDARDRGTWKPQSAVVLQSRCEGAGWSTRRGARE
                     NRPADAPAPTFAGEAHRWSWSLRSNNQANATVRRSDEPAGTLFFGHRANECVWVAEPAP
                     SDASGERPTPEPIRITAQEAGLLQTFPADYPWAGNKGQQFSQIGNAVPPRLAAHLLAPH
                     LRVPLDPDDFTLAA"
     gene            4392..5510
                     /locus_tag="P0D74_RS09410"
     CDS             4392..5510
                     /GO_function="GO:0003678 - DNA helicase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0006260 - DNA replication [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019070539.1"
                     /locus_tag="P0D74_RS09410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DnaB-like helicase N-terminal domain-containing
                     protein"
                     /protein_id="WP_275462299.1"
                     /transl_table=11
                     /translation="MPRTPTSDEDDLDTPTPPVFFAEQALLGALLLEPHRLGEVPGIRP
                     EAFSTAAHSAVFAAIRSLPAPDPAQHAQNTAWLDKVLACARKQARGLSASYLHTLIQVC
                     PRPRHAPAYARMIEAEHARRTLRAGAQRLGQAAGDRTHPQPVPRALVAADSLTDSVDRL
                     AATFPSGPASLPRTPAPALAPAHDGEEAAAEEERALLAAATALPAVIDQMRWLTADDFV
                     HPRNAGLWQAATALARRHAAVDPVTVLWEAQHHALLASGAEPAELLQALAGPAAGDPQY
                     WGERILQRSVLVTAHHVARHIEALTDDPATIPQQLLLGSRRALASLNAVRARWHQATSP
                     TPPPPPHASKAPARTRAGPPRTTAPGPSRATR"
     gene            5647..6360
                     /locus_tag="P0D74_RS09415"
     CDS             5647..6360
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF015713.3"
                     /locus_tag="P0D74_RS09415"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF317 domain-containing protein"
                     /protein_id="WP_275462300.1"
                     /transl_table=11
                     /translation="MPVFAADTADPADHDTLLDHFLDTHDEWAGWRTWSDDLTYATHES
                     QTLPIERDYSAPATETAWTVAAYQTPVSDRMWHLTATGATPIPMLQDLLHELADGHGWG
                     TPVGQFLDEASIIAATQSATDAGWKHTVEGRWMHWTAPNGESGIQFDAFAAQRTNGVLP
                     TWLLWAGPTIDHPTWEIAASTRTPSTLLTNLAETLTHGTATRPTIPLTPNAHHHTTPPP
                     ALPATAAKRANSRSL"
     gene            complement(6465..7037)
                     /locus_tag="P0D74_RS09420"
     CDS             complement(6465..7037)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="P0D74_RS09420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_275462301.1"
                     /transl_table=11
                     /translation="MSEWSFTLLINQPLTPEQADAFDHCDAFADGSVSYTLGPDNPEAY
                     PHRPSAEALRQLSCDIEAPTLLDAVAQVARDVRLIPGLRAVGVRYDDTVTLEEAAQRCG
                     RSHHELVELAKNQRGTGEFPGPESGGDGTQFYSWRKIAAYLTHAGDALADAPRDLVIAD
                     RALRLAEALEGADVSPGTLQSLGLPLA"
     misc_feature    complement(7067..7082)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: medium, score: 21.47"
                     /tool="antismash"
     gene            complement(7576..8364)
                     /locus_tag="P0D74_RS09425"
     CDS             complement(7576..8364)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016570465.1"
                     /locus_tag="P0D74_RS09425"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF5655 domain-containing protein"
                     /protein_id="WP_275462302.1"
                     /transl_table=11
                     /translation="MDTMLGVTFLASEYVIGCDGDSGRIDSLGIDENGSPVVVEYKRGT
                     DSGVINQGLYYLSWLLAHRDAFRALVRERLGATAASQILWSAPRLICVAGDFTRYDAHA
                     VREHRRSIDLVRYRYYGDDHIGLETVASVTGLSGTVKRSRRRAAGQRGVRQPGGALAEL
                     AEAVDEVLLGVGDGVTRVQRKQYVAYQRLCNFACVTPPQQTKLLIYLKANPKKVELIPG
                     FTRNVTKVGHHGTGNLEVQLRTERDLERAQDLFRLSYAAA"
     gene            8365..8556
                     /locus_tag="P0D74_RS09430"
     CDS             8365..8556
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="P0D74_RS09430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_275462303.1"
                     /transl_table=11
                     /translation="MHLDEALHIRLNLGKTRHNLDDAPTRCVKQLQARHLPLIDWTGDN
                     TEEGHIYFHIEVPATKTS"
     gene            complement(9045..9853)
                     /locus_tag="P0D74_RS09435"
     CDS             complement(join(9045..9517,9517..9853))
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1097: transposase"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012948683.1"
                     /locus_tag="P0D74_RS09435"
                     /note="programmed frameshift; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /product="IS5 family transposase"
                     /protein_id="WP_275462304.1"
                     /ribosomal_slippage=""
                     /transl_table=11
                     /translation="MRTDLVPDDLWERVAPLLPPSPERRHRHPGRLRVPDRAALTGIMY
                     VLRTGVAWRDVPAETVGCSGVTAWRRLRDWTEAGVWPRLHSALLIELRRANLLDLDDCA
                     VDGSHVRAPKRGDHVGPSPVDRARPGSKHHLIVDRHGTPLAVTLTSGNRHDVTQLLPLL
                     DAVPPIRGLRGRPRSKPRRLYADRGYDFDKYRRLLWKRGIKPLIARRGVAHGSGLGKVR
                     WVVERGFAWLHQFKRLRTRYERRADLHQGLLELACGIICLRRLRTAL"
     gene            complement(10001..10981)
                     /locus_tag="P0D74_RS09440"
     CDS             complement(10001..10981)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF040195.2"
                     /locus_tag="P0D74_RS09440"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_275462305.1"
                     /sec_met_domain="T1TS (E-value: 3.4e-54, bitscore: 183.8,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEKLVGYCYPHARGEGLDLCNKLMTFAVLVDDQIDGNSRADSRSC
                     SLAVQPFLDTLHANGQPPARSNPLCQVFGEILRESRAATSPAWWARAAADWEYYFHSVV
                     HERNDPILRGSAPGPVDVYLEIRRGTGVMGPMLDILEPGAGFEAPPLMFHSPQLRLMRR
                     LVVDMVDFLNDVFSLEKEIARGEHSNIVLVLQAARNLSLVKAEAAARSLIQQHARRFLD
                     LKEELSEACLTMSLEEPQRGATLQYADALEMWVAGFEPWQRQSPRYLDALSERPPDGPW
                     ARDDLLGRRPAGQGANARAEQPSYGDEEPASARLVDRCTGSEGET"
     gene            complement(11148..12485)
                     /locus_tag="P0D74_RS09445"
     CDS             complement(11148..12485)
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012296.3"
                     /locus_tag="P0D74_RS09445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="cytochrome P450"
                     /protein_id="WP_275462306.1"
                     /sec_met_domain="p450 (E-value: 4.5e-58, bitscore: 196.0,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAVLVQRPVTAPGAWPLIGHIARLAKDPLAFVGRLHDVAPVVRIL
                     LGPHEAFIVTRPDLVRRLLVADQDRFDKGGPVFDKMRLFLGNGLSTCPMADHSRQRALM
                     QPGFHRTRIEHYADVVRDVLEEVTGAWWNGQMLRLEDEVHRVTALATTRSLVSSEQGLR
                     AADQLAVAIPDIFQGLYWRMVIPSRLFPRIPLPVNRRFDRQTANVRRLVDDVVAHYRAD
                     GIDRGDLLSMLIPACETEQDPQQAIYDQAITILTAGVETAAGTIVQALRLLDQHPQYAQ
                     RLLDEADQALAGRAPGHADLPNLPYAHHVVTETLRLYPPTWLLSRVTLQHVDWNEGWIP
                     AGSDVLFSPYALHRVAEVFPDPEAFDPDRWNRERVTTIQRQGFFALGAGRRKCIGDVFG
                     INEAVIAVVSILSRWTLSFAQHPTTAKNTLRMLLMPPPSVVRVEAR"
     misc_feature    12786..12804
                     /note="TFBS match to DmdR1, Iron(II)-dependent repressor,
                     confidence: weak, score: 23.67"
                     /tool="antismash"
     gene            <12898..13137
                     /locus_tag="P0D74_RS09450"
                     /pseudo=""
     CDS             <12898..13137
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018561156.1"
                     /locus_tag="P0D74_RS09450"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="DUF190 domain-containing protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="LARGAVCHRAEAYSASSLIHTARLPSLSEDLPVAIIIVDAEERIR
                     AFLPRLHELIHEGLVILDEVEVKRYVGRNKDKDA"
     misc_feature    12988..12990
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(13215..13727)
                     /locus_tag="P0D74_RS09455"
     CDS             complement(13215..13727)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006345236.1"
                     /locus_tag="P0D74_RS09455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="FBP domain-containing protein"
                     /protein_id="WP_275462307.1"
                     /transl_table=11
                     /translation="MTREEVRASIVNLGPTEKKVRLPAWFDDAPWHRIDYLGWRDMRAA
                     QRAYLVTEADDQALGVLLRQAPNDAAHTSRALMCDLCRSTRRFNEVSLFTAQRPSRDKR
                     ERLNTLGLHLCTDLDCAVKMHTKPIRQTFDPPVDDIIATRREGMRSRTIAFIRSVSDAQ
                     RTTRRQR"
     gene            complement(13926..14357)
                     /locus_tag="P0D74_RS09460"
     CDS             complement(13926..14357)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010056536.1"
                     /locus_tag="P0D74_RS09460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="RNHCP domain-containing protein"
                     /protein_id="WP_275462308.1"
                     /transl_table=11
                     /translation="MPRRVNSPRRRAQAARRPQRYKDVLHSQHGHQGHDFRCVGCRLDV
                     SLDAPGTTHRNHCPNCLASLHVDRRIPGDRAATCRGRMEALSMSVRPDGEWMIIHHCLS
                     CGELSANRIAGDDNALALVRLALKPLRDASIAQRTLLAL"
     gene            complement(14380..14760)
                     /locus_tag="P0D74_RS09465"
     CDS             complement(14380..14760)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019432951.1"
                     /locus_tag="P0D74_RS09465"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="RNHCP domain-containing protein"
                     /protein_id="WP_275462309.1"
                     /transl_table=11
                     /translation="MSSTNKSLPSTPRTILTGTFTCAWCGLTVSAAAGDGTRRNHCPSC
                     LHSQHVLDHVEGGRSDCQGRMSPIAIAVLRTGDWMVIHRCVRCDELTSNPVCADDNQLI
                     LIRMAVRPLAQPPFPLEAFGDL"
     misc_feature    14983..14997
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 18.6"
                     /tool="antismash"
     gene            complement(15384..16502)
                     /locus_tag="P0D74_RS09470"
     CDS             complement(15384..16502)
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1229: transposase"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011000070.1"
                     /locus_tag="P0D74_RS09470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="IS630 family transposase"
                     /protein_id="WP_275462310.1"
                     /transl_table=11
                     /translation="MTSSGASVPRRGPKLEPLLLCDEERAVLERWMRRATSAQALALRA
                     RIVLACAGPEVPPIVAVARDLRVTADTVRKWRRRFLADRLDGLADEPRPGRPPTVDVDQ
                     VEAVVVATLEEIPKNATHWSRKSMADHSGLSKSTIGRIWRKFQLKPHLTDTFKLSTDPL
                     FVEKIYDVVGLYFNPPEGAVVLSVDEKSQIQALDRSQPVLPMMPGMPERRTHDYVRNGL
                     TTLFAAFDVATGEVISALHRRHRAAEFKKFLIRIDKEVPAHLQVHLIVDNYGTHKTPAI
                     KAWLGKHPRFQLHFTPTGSSWMNQVERWFGFLADQMIRRGAHKNVQALEADIRTWVKNW
                     NEDPKPFIWTKTAEEILDSLARFCRRISGAGH"
     gene            complement(16565..17911)
                     /locus_tag="P0D74_RS09475"
     CDS             complement(16565..17911)
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1229: transposase"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015654835.1"
                     /locus_tag="P0D74_RS09475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="IS630 family transposase"
                     /protein_id="WP_275462311.1"
                     /transl_table=11
                     /translation="MSRGPRAVDVVLSDEERAELLRWAAGAVVARLAERARIVLACADG
                     LPNARVAAEFEVSADTVRKWRSRFTARRVAGLADEPRSGRRKAELVLSDAERAQLVRWS
                     RRAKTAQFLALRAKIVLRCAEGGTNKQVAAELGVGHQTVNRWRARFIGHRLEGLVDEPR
                     VGRPPSILLDQVEDVVIATLESTPGKDTHWSRASMATRTGLSKSTIGRIWKKFDLKPHL
                     QDFFKLSTDPRFVDKVVDVVGLYHNPPEKAVVLCVDEKAQIQALDRSQPVLPMMPGMPE
                     RRTHDYLRHGITSLFAAFNIADGTVIGELHRRHRAIEFKKFLTTIDKAVPAGLDVHLVC
                     DNYATHNTPEIKAWLGKHPRFHVHFTPTGSSWINQVERWFGLLTDKLIRRGVHTSVKAL
                     EADIRAWIDTWNENPRPFRWTKSADEILTSLAGYLSRITPPDTNNQPET"
     misc_feature    complement(17147..17149)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            18022..18867
                     /locus_tag="P0D74_RS09480"
     CDS             18022..18867
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005477036.1"
                     /locus_tag="P0D74_RS09480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="transposase"
                     /protein_id="WP_275462312.1"
                     /transl_table=11
                     /translation="MTARVPCPPAPGPLEGYAAPFDDLFGTLAQRRGFRQYLTGLLAPR
                     DRNKTLTSLAGAEPVVGAQHRAAQRLQFFRSESTWDCERLNDRRPELLLDNPATAPHEQ
                     GVLVIDDSGDRKDGKATAHVGHQWLGRYGKTDNGVVTVTTLRADERMYYPLHAVPYTPA
                     HHFPKGKNDPAFRTKWRITSALTGRAQAAGILSRAVVANYVYGDVDAFRGELSQAGVPF
                     AMALKRRRGVWAYGDQSGAATSPRPVSLSDSVLSPLPTSTLRAASPRTMCMSWPAHGRT
                     "
     gene            18786..19037
                     /locus_tag="P0D74_RS09485"
     CDS             18786..19037
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF025387.3"
                     /locus_tag="P0D74_RS09485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="TNT domain-containing protein"
                     /protein_id="WP_275467532.1"
                     /transl_table=11
                     /translation="MPPANLYLEGSKSSYYVYELARPWSDIAKYGKAGDIQAGQIAPWF
                     EQPGGGIQYKLPKLTTADGKSFDLNVKWLKENGFLKAG"
     gene            complement(19225..19476)
                     /locus_tag="P0D74_RS09490"
     CDS             complement(19225..19476)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="P0D74_RS09490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_275462313.1"
                     /transl_table=11
                     /translation="MTITVSEIAAAARGVARVLYGKPVDLVEFRQTLDGHPFAEVKDGV
                     IHHIVRERGRELHHATYDDLDEFMYQVTKDATSSIASD"
     misc_feature    complement(19467..19487)
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: medium, score: 30.02"
                     /tool="antismash"
     gene            19876..20379
                     /locus_tag="P0D74_RS09495"
     CDS             19876..20379
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1238: transposase"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016577281.1"
                     /locus_tag="P0D74_RS09495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="winged helix-turn-helix domain-containing
                     protein"
                     /protein_id="WP_275462314.1"
                     /transl_table=11
                     /translation="MEEMGLTCEGRLQREKLRLQAAEWFEEGIAQAEIARRLGASRQAV
                     HVWHKKWKNGGTQALRSSGPWGRRPLVSEDEFTQVAEALKQGPAAHGFTGGVWTLARIR
                     RVIKEATGAEYTSPSGVWRLLKRHGWSRQTPTRRAYERDEKAVMTWRSEVWPQVKPQPS
                     TAEQ"
     misc_feature    20053..20055
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            20376..20927
                     /locus_tag="P0D74_RS09500"
     CDS             20376..20927
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1238: transposase"
                     /gene_kind="other"
                     /inference="COORDINATES: protein motif:HMM:NF024751.3"
                     /locus_tag="P0D74_RS09500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="transposase"
                     /protein_id="WP_275462315.1"
                     /transl_table=11
                     /translation="MIVFSDESGLSLLPPVRRTWAPAGQTPTLQMRMGQRPKVFVVGWC
                     CYSLGQPARYFYRVVPGSVTDRILIRQLHQVHRSLGRPIVLIWDNLSSHRSRRMRAFAA
                     RSHWLTLTYLPPYAPDLNPVEGGWAHLKNGPLANLGARTLDELLTTARRGLRHIQRHPA
                     LVTGFLAATHLDWNPQPSTS"
     misc_feature    20592..20594
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
ORIGIN
        1 atggcgcccg gcacgaaccg actgattatc tggcgttcgg cggtacgcgg gtgcggcaca
       61 gatgtcggcg actggttccg cttgggcacc ggccgcaaca gtgctggtca ttgggcacag
      121 ctggcagggg tggctggctc tccgtttcgg cgcgggcggc gcacggtgaa tgtggtcgag
      181 cgccgtgagc cgggccagaa cagtcaggac acccacgatc ggacctacgt cctgcccgac
      241 ccgcgggctc aggaggccgc cgtcccggtg atcgcggcgg ccgccgaagc tgcccgacag
      301 caggcagaac gggtagtact ggcggctgaa ctgcgtgatg cgccggtggc aggggatgca
      361 gaggcggcga ccgctgactg ccgggacttc ggcaacggcc cctttcccgg cgcggacggc
      421 cgctgcgggg cctcgttcct ggcctgcttg ggttgcacca acgcgcgtat tcaccctgga
      481 catcacgccc ggctggccca tctgcaccga gccctgtccc agctgcgcag cgcgatgaat
      541 ccggcgttgt ggcaggccga ttggggcgag gcccatgccc ggctcgggca tctcagccga
      601 cgtctgggag tggcggcctg ggccaaggcg ctggccgagg tgagtgccga cgaccgggag
      661 ttgatcgacg acctgctgaa cggaggactc tccgcgtgaa cctcatcgcc atagccggca
      721 ctgatcccct acccggcccg gacaccccgg tcttcggccc gcaggtgctc actgaagggt
      781 atgccggccc cgtcatccgc tacggcgacg acatctggcc cctgtcgccg atgaacagca
      841 acccgagcgc cgacgcccac gccatccact ggagcggctt cccgaccggg ctgcgcgagg
      901 agttccgcct gatcgcctgg acaatgatca acggttccct ctccgcgagc ttcgtccgcg
      961 cacgcgccac ggcctggcgc aaccgcacca gcgcgcccac catctaccag accgtgtggc
     1021 tctggcgccg catggcgacg tggatgcacg agcagggcct ggacacgctg cgctcatgcg
     1081 gcagcacgac cttggagaag tacgcgagtt ggcttctgga gaccggagcc acccgcagcc
     1141 gagtccacaa ggtgctcatc acgctgaccc ggctctgggc ctttgatgcc ctcggcccgc
     1201 atcctctcgg tgtcggcagg cccccgtggg acgtccatgg agtcgacgac tatctgccgc
     1261 ccgcgaccac cgcccaaacc ggggagaacc tcaccgagga gctgtcgccc gagaccatgg
     1321 ggccgctgct gatctgggcg atccgcctgg tcgacgactt cgccgaggac atcctggccg
     1381 cggacgccga acgccgcagc cttcgctccg cgacactcgc caacgtcggg acccccgaca
     1441 cgctgaccgc gctgcgttcg tacatcgacc gacggctcgc agccgaccag ccgctaccga
     1501 cgcacgtcca cgccggccgc cgctgtctga acacccacta cgtcgccggc acgaccggcg
     1561 cttccctcga ccaggtccac cgtcggctcg ggacgccgtc ctggaaacaa gcggtgaccc
     1621 gacgcccagg tccgtgccca ctcagcatcc gcatcacggg cgccattgac ggccaaccct
     1681 ggcgcgccgc catcgacttc aacgagacgc tcgaccttat gcggcacctg accgccgcgt
     1741 gcttcatcat catcgcctat ctcaccggca tgcggcccgg cgaggtcctg gggctacgtt
     1801 ccggctgctg tcccgacccc gtaccggacg agaacggacg ccttccccag cacaaggtct
     1861 acggccatgt ctacaagacc gcccgcgacg atggcggcaa ccatgtgtca gccggcgtcg
     1921 tgcgcgaggc cccctgggtg gccattgcgc ccgtcgtcca cgcggtccgc gtcctcgaac
     1981 gcctcgtccc ctccggggcc ctgctgttcg accaccgtgc ccactacctg ggcaagggca
     2041 cggtgcagaa cggggacggc tcactgcgga tctccacgat caggggccgc atcgaggagt
     2101 tcatcgtctg ggcgaacgcc gaagccagcg ccctcggcag ggcccatgag gtcatcccgc
     2161 ccgatccgca cggcagcatc ggaaccgaac gtttccggcg caccctggcc tggcacatcg
     2221 cgcgtcggcc gggtgggctg gtggccctgg ccattcagta cggccacctg cggaccacca
     2281 tctcggccgg ctacgcctcc tgcagccgtg acggcatcca caagttgctg aacgtcgaga
     2341 cagcccgagc gaccatcgac accatcaccg acctccagga cgacctggac aacggcatcg
     2401 gcgtctccgg ccccgcagcc cgccgcgcga tcaacgcagc tgccaccgct ccgcagttcc
     2461 agggcacgat cgttacggct cgcacggcac gcaagatcct caacaacccg gccctggccg
     2521 tctacgacaa ccccaacacg ctactgatgt gcgtctacaa ccgggatcga gccctctgcc
     2581 accgcgacac cgacaacgaa agcccgagcc tggaccgctg cgtcagcgcc tgcgcgaaca
     2641 tcgcgcgatc cgaccaccac gccgaccagc tccgcgagcg ggccaccgct ctggacacac
     2701 gggccagccg cctgcccggc ccgatcgggg accgcctgcg cggcaacgca gccaaatgcc
     2761 gcgagatcgc cgatgaccac gaccgcaccc gcatcgtcct tccggagacc gccccgtgac
     2821 gcctgccctg gatgaacgca aacgcatccg cgccgcgatg gaccgcatcc tggccgggac
     2881 ccccgaacgc tccaacggcg cgttgacaat cgtcgctctc gccacagaag ccggagttcc
     2941 tcgcaacgcg ctcacgcagc gccacctcga cctgaaggcc gagttctacg acaaggtccg
     3001 ggcccgcggc gagatgccag acagcgagaa gcgcctgcgc cagcagatcg tcaagctcaa
     3061 agagctccgg gaagccgaca aggccgcgat cacccgtctc cagaccgacc tcgaagccgt
     3121 cgtccgagtc gtccaccaac tcaccgtgga gaaccggcag ctgcggaccg aactcaccac
     3181 ccctgatgca cgggtacgag ttcttccgac tcagcctcgc ccaactgact gacctcacga
     3241 accgggctcc actcacctct ccaaggagga caccacatcc gagatcagat tcatcgaaag
     3301 attcaacacg caggacttga tagggaaccg ccctgccagg cgtggtcgat ggccggcaag
     3361 cgcctcggcc tcctcgacca gccgctcgtc caccaggccg tcgccgacct cgccatcggc
     3421 cgcgacaccc gcgaactcct gctggccgcc tgtcgcgacg aacgctcact gctcgccgcc
     3481 gagcccatgc gctacctgca cgccctcaat cagcacgggc aacctgagtg ggtcgcgatg
     3541 gaagaggtgc ccgacgtcct gcccctgtgg cgccagtacg ccgcgatcct gcgcagctgg
     3601 gggttctcgg tatggaccgg gatcctgaac gccgccgact acggggtgcc gcagacgcgg
     3661 cggcgggcga tcctgctcgc ctcccgcact cggaccgccg agccgccgca gcccacgcat
     3721 gccaaggcgg ccgagcccga gtcgctgttc gggccgggcc gcgcgcagtg ggtgtccatg
     3781 gccgaggccc tcggctgggg agccaccgac cgtcccgtgc cgaccgtgtg cgccggcgga
     3841 ggaccgggcg gcggccccga gcccttcccc tccggatccc gtaagacgct caccgacgcc
     3901 cgcgatcgtg ggacgtggaa gccgcagagc gccgtcgttc tgcagtcgcg atgtgagggt
     3961 gccgggtgga gtacccggcg cggagccagg gagaaccggc cagcggacgc tcccgcgccc
     4021 acgttcgctg gcgaagcaca tcgctggtcg tggtctctgc gcagcaacaa ccaggcgaac
     4081 gcgaccgtgc gtcgatccga cgagccggcc gggacgctgt tcttcggcca ccgtgcgaac
     4141 gagtgcgtct gggtcgccga gcccgctccc agcgacgcga gcggggagcg gccgacgccg
     4201 gagcccatcc ggatcaccgc ccaggaggcc ggcctgctgc agacgtttcc tgccgactac
     4261 ccgtgggccg ggaacaaagg ccagcagttc tctcaaatcg ggaacgccgt gccgccccgg
     4321 ctcgccgccc acctgctggc accgcacctt cgcgtgcccc tcgaccccga cgacttcacc
     4381 ctggccgcct gatgccccgc accccgacct ccgacgagga cgacctcgac acccccacgc
     4441 caccggtgtt cttcgccgag caggcgctcc tcggcgccct cctcctcgaa ccccaccgcc
     4501 tcggcgaggt ccccgggatc agacccgagg cgttctccac cgccgcacac agcgccgtgt
     4561 tcgccgcgat ccgctccctg cccgcccccg acccggccca gcacgcacag aacaccgcct
     4621 ggctcgacaa ggtgctcgcc tgcgcccgca agcaagcccg cgggctgagt gcttcctacc
     4681 tgcacaccct gatccaggtc tgcccgcggc cccggcacgc acccgcctac gcccggatga
     4741 tcgaagccga acacgcccgc cgcaccctac gcgcaggcgc ccaacggctc ggccaggctg
     4801 ccggcgaccg cacccacccg caaccggtcc ccagagccct cgtagccgcc gactccctca
     4861 ccgacagcgt cgaccgtctc gccgcgacgt tcccgtcagg cccggcctcc ttgccccgca
     4921 cgcccgcgcc ggccctggct ccggctcacg acggggagga ggcagcagcc gaggaggagc
     4981 gagcgctgct cgccgccgca acagccctcc ctgccgttat cgaccagatg cggtggctga
     5041 ccgccgacga cttcgtccac ccgcgtaacg ccgggttgtg gcaagctgcc accgctctgg
     5101 cccggcgtca cgccgcggtc gacccggtca ccgtcctgtg ggaagcccag caccacgcgc
     5161 tgctcgcctc cggcgccgaa cccgcggaac tcctgcaggc gctcgcaggg ccagccgccg
     5221 gcgacccgca gtactggggc gagcggatcc tccaacgctc cgtgctggtc acagcgcacc
     5281 acgtagcccg ccacatcgag gcactcaccg acgacccggc caccatcccg cagcaactcc
     5341 tcctcggcag ccgccgcgcc ctggccagcc tcaacgccgt gcgcgcccgc tggcaccagg
     5401 ccacctcccc cacaccaccg ccccctcccc acgcgtccaa agccccggcc cgcacccgag
     5461 ccggcccacc ccgaaccacc gccccgggcc cttcccgcgc cacgcgctga cattcacccc
     5521 gcaggcaacc aggacacgaa gcccgactgc cagaagaagc gagtgcacag tggcgacatc
     5581 gccctccccc gccctccacc gtcgagttcg cctcgaacag cacgccactg ataccgaaaa
     5641 gagaccgtgc ccgtcttcgc cgccgacacc gctgaccctg ccgaccacga caccctcctc
     5701 gaccacttcc tcgacacgca cgacgaatgg gcagggtggc gcacttggtc cgacgacctc
     5761 acctacgcca cccacgaatc tcagaccctg cccatcgaac gcgactactc ggcccccgcc
     5821 accgagaccg cctggaccgt cgccgcctac cagacgcccg tctccgaccg gatgtggcac
     5881 ctgaccgcga ccggcgccac gcccatcccc atgctccaag acctgttgca cgaactcgcc
     5941 gacggccacg gatggggcac tccggtcggt cagttcctcg acgaggcgtc catcatcgcg
     6001 gccacccaat ccgccaccga cgccggctgg aagcacaccg tcgaaggccg ctggatgcac
     6061 tggaccgcgc ccaacggcga gtcaggcatc caattcgacg ccttcgccgc ccaacgaacc
     6121 aacggagtcc tgcccacctg gctcctgtgg gccggcccca ccatcgacca ccccacctgg
     6181 gaaatcgcag cctccacccg cacccccagc accctgctga ccaacctcgc cgaaacgctc
     6241 acccacggaa ccgccacccg cccgacaatc cccctcaccc caaacgccca ccaccacacc
     6301 acgcccccgc ccgcgctccc tgccaccgcg gccaagcgcg ccaacagccg ctccttgtaa
     6361 cctccagcag ggaagcgatc accagcagtt ctccggcagc ccgaccccgc cttgggacac
     6421 tcgccgaatg cctcggggcg gcgtcccctt cgtacgggta cctgtcaggc gagcggcagc
     6481 cctagggact gcaaggtgcc tggcgacacg tccgcgcctt cgagcgcttc ggcgaggcgc
     6541 agtgcgcgat cggcgatgac gaggtcgcgg ggcgcgtcgg cgagagcgtc gccggcgtgt
     6601 gtcaggtatg cggcgatctt gcgccaggag tagaactgcg tcccgtcgcc tccggactcg
     6661 ggccccggga actcgccggt tcccctttgg ttcttggcga gttcgacgag ttcgtggtgg
     6721 ctgcgtccgc agcgttgtgc ggcttcctcc agggtcacgg tgtcgtcgta gcgcacgccc
     6781 acggcccgca ggcccgggat gagtcggacg tcgcgtgcca cctgtgcgac ggcgtccagc
     6841 agcgtggggg cttcgatgtc gcatgacagc tgcctcagcg cctcggcact ggggcggtgc
     6901 gggtacgcct cggggttgtc ggggccgagg gtgtaggaga ccgagccgtc ggcgaaggca
     6961 tcacagtggt cgaaggcgtc ggcctgctcg ggggtgaggg gctgattgat caggagggtg
     7021 aagctccact cggacacagc ggctgccctt tcagtgctgg tggtccttga cgaagcggtc
     7081 aacgcgcttc gcctcattgc cgggattctt cggagtacct gagacgacgt ggcgtgctcc
     7141 acacgagcag cacaccaccc atccccaccg gtgcccattc ttgtccggca ccacctggca
     7201 accggctctc ctggcccgat caaggaccgc cgcaacatcc ccgtcctgat gccgtccctt
     7261 ggaaatcacc cgcagcaccc tactcaccgc agccgtaagt tcgcagccag taatgtgccg
     7321 cgaagggcaa ctcgaccgag aaccagccac tgcgaagtgg aggcgcatgc ccgcctggta
     7381 gcgcagtcgc cgctggcccc cgcctccagc tcacgtgagc gggcgcaaca tagcggggga
     7441 tcgccggtta gccaaaccgg cgatcccccg catcattgat agtccaccgc cacccaccgc
     7501 ccctccgtcg aagggcccgg caacgcaggc atcacttccc cgaagaacgc tcccgctcgg
     7561 cgcgcccgcc agccatcacg ccgcggcgta gctgaggcgg aacaggtctt gggcgcgctc
     7621 caggtcccgc tccgtgcgca gttggacttc cagattgccg gtgccgtggt ggccgacctt
     7681 tgtcacgttg cgggtgaagc cggggatgag ttcgaccttc ttcgggttgg ccttgaggta
     7741 gatgaggagt ttggtctgct gcggcggggt gacgcaggcg aagttgcaca gccgctggta
     7801 ggcgacgtac tgcttgcgct gcacccgcgt gacaccgtcc ccgacgccga gcagcacctc
     7861 gtcgaccgcc tcggccagct ccgccagcgc tccgcccggc tggcgaacac cccgctgccc
     7921 ggccgcgcga cgacggctcc gcttgactgt gcccgagagc ccggtgacgg aggcgacggt
     7981 ctccaggccg atgtggtcgt cgccgtagta ccggtagcgg accaggtcga tgctgcgccg
     8041 gtgctcgcgc accgcgtggg cgtcgtagcg ggtgaagtcg ccggcgacac agatcagccg
     8101 cggtgcgctc cacaggatct gggacgcggc cgtcgctccc agtcgctcgc ggaccagggc
     8161 acggaaggcg tcccggtgcg ccaggagcca ggacaggtag tacaggccct ggttgatcac
     8221 tccggagtca gtgccccgct tgtactcgac gacgacgggc gaaccgttct cgtcgatacc
     8281 cagcgagtcg atccgtccac tgtcgccatc gcagccgatg acgtactcgc tggccagaaa
     8341 cgtcacgccc agcatcgtgt ccatgtgcac ctcgacgagg ccctgcacat ccgcctcaac
     8401 ctcggcaaga cgcgacacaa cctcgacgac gcccccactc gttgcgtgaa acagcttcag
     8461 gcccgacacc tccccctcat cgactggacc ggtgacaaca ccgaagaggg gcacatctat
     8521 ttccacatag aggtcccagc cacgaagacc tcgtgagatc ctgccaatac agaccccacg
     8581 agccgcctac atcccatgag ttcgagacag ccgctcatcc cacatacgtc ccacaaaact
     8641 catgacgccc tgccagatac ctaaaagtac gcaggtcaga cggtgttgag ggtagacgga
     8701 ttaagcgcct tctgagcgcc tagccgcagg ttcatgaccc actgagagcg gcgctgacgg
     8761 ctccgccggc tgtgcgacgc gactgcaaat cagcctgcat ctagctgacc tttcagcgag
     8821 gtccgctccg ccaggacgac gcgcggctgg caccagttac caccgcagcc cgcgcacccg
     8881 ctactgccgt atagtcggct ggatcctcct gctgagactt acggtcgccc gaaggacggc
     8941 tgccacaacc ccctggacgc gctcgcccct cacctccccc gctgtggtga tcctctgctc
     9001 ccccggaggg cgaccgccgc gttctccccg cctagctgat cgtttcacaa tgccgtccgg
     9061 agtcgccgga ggcagatgat gccgcaggcg agttcgagca ggccctgatg gaggtcagcg
     9121 cgtcgctcgt agcgggtgcg gagtcgcttg aactggtgca gccaggcgaa cccacgctcg
     9181 accacccagc gcaccttgcc caacccggaa ccatgggcga caccacgtcg ggcgatcagc
     9241 ggtttgatgc cgcgcttcca caataggcgg cggtacttgt cgaagtcgta gccgcggtcg
     9301 gcatacaaac gccggggctt gctgcggggg cggccacgca agccccggat cggtgggacg
     9361 gcgtccagca gcggcaggag ttgggtgacg tcgtggcggt ttccgctggt gagcgtgact
     9421 gcgagtgggg ttccgtggcg gtcgacgatc aggtggtgct tggatccggg gcgggcacgg
     9481 tcgacgggag acgggccgac atggtccccc cttttagggc ccggacgtgt gagccgtcca
     9541 cggcgcagtc gtccaggtcc agcaagttcg cgcggcgcag ttcgatcagc agggccgagt
     9601 gcaggcgcgg ccagacaccg gcctcggtcc agtcccgcag ccgacgccag gccgtgactc
     9661 cggaacagcc cacggtctcg gcggggacgt cgcgccaggc aacgccggtc cgcagcacgt
     9721 acatgatgcc ggtgagagcc gccctgtctg gaacacgaag ccgtccgggg tggcggtggc
     9781 gtcgttcggg agaggggggc agcagtggag ccactcgctc ccacaggtcg tccgggacaa
     9841 gatcagtacg cacccggcaa ccctgccgac catgatcgcc gagcgcaagg cccaccgctc
     9901 aggtcatcgg ccaaccgaca cggtccgctg acctgcgaga accgttcggt gatgccccgc
     9961 ttgttccctc gatcacggag actgcgtccc acgccgctgg tcaggtctcg ccttccgatc
    10021 ccgtgcagcg gtctacgagc ctggccgacg cgggttcttc gtcaccgtac gaaggctgtt
    10081 cggcgcgggc attcgcccct tgcccagcag gacgccggcc gagcaggtcg tcacgggccc
    10141 atggcccgtc aggggggcgc tcggacagag cgtcaagata ccgaggtgac tgtcgctgcc
    10201 acggctcgaa gcctgccacc cacatctcca gcgcatctgc gtactggagg gttgccccgc
    10261 gttgtggttc ctccagggac atcgtcaggc atgcttccga aagctcctcc ttgaggtcga
    10321 ggaatctgcg tgcgtgctgc tggatcaagg accttgctgc ggcttccgcc ttgaccaggg
    10381 agaggtttcg cgctgcctgc agcacgagca cgatgttgct gtgctcgccg cgcgcgatct
    10441 ccttctccag ggagaagaca tcgttgagga agtcgaccat gtcgacgacc agacgtcgca
    10501 tgaggcgcag ctgcggcgag tggaacatga gcggcggggc ctcgaatccc gctcctggct
    10561 ccaggatgtc gagcatggga cccatcacac cagtgccccg ccggatctcc aggtagacgt
    10621 cgacggggcc aggagcggac ccgcggagta tcgggtcgtt ccgctcgtga acgaccgagt
    10681 ggaagtagta ctcccagtcg gcagcggctc gtgcccacca ggctggcgac gtggcggctc
    10741 tggactcgcg cagaatctct ccgaagacct ggcacagtgg gttcgaacgg gcgggcggct
    10801 gaccgttggc gtgcagggtg tccaggaagg gctggacggc caggctgcag gatctgctgt
    10861 cggctctgct gttcccatcg atctgatcgt cgaccaggac cgcgaaggtc atcagcttgt
    10921 tgcacaggtc taggccctca ccgcgggcat gcggatagca gtagccgacg agcttctcca
    10981 tgtcccaaga gcagtaccac tggtaagact cgttgctggc cgtcaggcca cgggacctca
    11041 cccaggcgcg attgcgttcc cgggcttcgt ccagctccgg gtttcgtcga aaccgtagcc
    11101 ccagctctac cggctctcgc atgacagttt cctctcccac acctgggcta ccgtgcctcc
    11161 acgcgcacga ccgacggtgg cggcatgagc agcatgcgca aggtgttctt ggcggtggtg
    11221 gggtgctgcg cgaaggagag cgtccaccgg ctgaggattg agacgaccgc gatgactgcc
    11281 tcgttgattc cgaagacgtc accgatgcat ttgcggcggc ccgcgccgag ggcgaagaac
    11341 ccctggcgct gaatggtcgt gacgcgctcg cggttccacc ggtcgggatc gaaggcttcg
    11401 gggtccggga agacctcggc cacccggtgc agcgcgtagg ggctgaacag tacgtcgctc
    11461 cctgccggaa tccacccctc gttccagtcc acgtgctgca gagtgacacg gctgagcagc
    11521 caggtcggtg gatatagccg tagcgtctcg gtcaccacgt ggtgggcgta ggggaggttc
    11581 ggcagatcgg cgtgaccggg ggcgcgcccg gcgagggcct ggtcggcttc gtccagcagc
    11641 cgttgtgcgt actgcgggtg ctgatcgagc aagcgtagtg cctgcacgat ggtgccggcg
    11701 gcagtctcca cgcccgctgt caggatggtg atggcctggt cgtagatcgc ctgctgcggg
    11761 tcctgttcgg tctcgcaggc gggtatcagc atcgacagca ggtcgccgcg gtcgatgccg
    11821 tcggctcggt agtgggcgac gacatcgtcc accagacggc gcacgttggc cgtctgccgg
    11881 tcgaatctgc ggttcaccgg cagcggaatc cgggggaaca gtcggctggg gatgaccatc
    11941 cgccagtaga ggccctggaa gatgtccggg atggccacgg ccaactgatc agccgcgcgc
    12001 agcccttgct ctgatgacac cagcgaccgc gtcgtggcca gtgcggtgac ccggtgcacc
    12061 tcgtcctcca ggcgcagcat ctgcccgttc caccaggcgc cggtgacctc ttccaggacg
    12121 tcgcgcacga cgtcggcata gtgctcgatc cgggtccgat gaaatccagg ctgcatgaga
    12181 gcacgctggc gcgagtggtc ggccatggga caggtactca gtccgttgcc gaggaacaga
    12241 cgcatcttgt cgaagaccgg gccgcccttg tcaaaccggt cctggtctgc gacgagaagt
    12301 cggcgcacca ggtcgggacg tgtcacgata aacgcctcgt gcggcccgag caggatccgc
    12361 acgacgggag ccacatcgtg aagtcggccg acgaaggcca aggggtcttt cgccaagcgc
    12421 gcgatgtggc cgatgagtgg ccaggctccc ggcgccgtga caggtcgttg aacaagcacc
    12481 gccattcgga cccccaacag tggctatggc cgaggccagt ttcgcagggt gttcctcctt
    12541 cgcaggatcg atcggcacgc tcactgatca caacaaggcg ccctggactg gtcgcagttg
    12601 aaagaagatg cccgagaact cccctttgat gctaatttca caagcctcac tgattgttct
    12661 cgtgcgggct gcgacgcggc cgctcgcccg cctgcggcga agtcctcgtc cgtcgggtcc
    12721 accccagggc ggcgcggtgc cgccgctttg accgacacaa gctcaagaat cggtatgacc
    12781 agccttttgg cttggctgac ctcattctga aacgatcagt agggcgtcgg catgcttagt
    12841 ctggctccga ggcccagctg cgccgacggg tgaccgccgc gaggtaggtg acacccactg
    12901 gcacgaggtg cggtgtgcca tcgggccgag gcgtacagcg cctcctccct catccacacc
    12961 gcccgcctcc cctccctcag cgaagactta cccgtggcga tcatcattgt cgacgccgaa
    13021 gaacgcatcc gcgccttcct gccccgactc cacgagctga tccacgaggg cctggtcata
    13081 ctcgacgagg ttgaggtcaa gcgctacgtc ggacggaaca aggacaagga cgcataagtg
    13141 aactggctgt tcgtcatagc cggagccaag gtcggagtcc cgtggaatcc gcctgcggag
    13201 agctctcgat cacatcacct ctggcgtcgc gtggttcgtt gcgcatcgga caccgaacgg
    13261 atgaaggcga ttgtgcgcga gcgcatgcct tcacgacgcg tagcgatgat gtcgtcgacc
    13321 ggcggatcga aggtctggcg gatcggcttg gtgtgcatct tcaccgcgca gtcgaggtcg
    13381 gtacataggt gaaggccgag tgtgttcagg cgttcgcgct tgtcacgtga ggggcgttga
    13441 gcggtaaaca gcgaaacctc gttgaaccgg cgggtggagc ggcacaggtc gcacatcaac
    13501 gcgcgcgatg tgtgtgccgc atcgttcggg gcctgccgca gcagcactcc cagcgcctgg
    13561 tcgtcggcct cggtgacgag ataggcgcgc tgcgcggcac gcatgtctcg ccacccgagg
    13621 tagtcgatcc ggtgccaagg ggcgtcgtcg aaccaggccg gtagccgaac cttcttctcg
    13681 gtcgggccca ggttcacgat cgaggcgcgt acctcttctc tggtcatggg gcgcatcgtt
    13741 actccttgcg cgttgcaccc tggtgcaacg tgtgtcgggt gaggttctgg gggatccggt
    13801 gcgtcgaggt gtcgccacgc ctgctcgccg tgtgtcgcag gggtgcgcgg gttggcgacc
    13861 gcggcacgaa ccgatcacgt tcgtcggggg tgtcctgtga cgcgacgccg cgaggtcggc
    13921 cggggtcata gggccagcag cgtgcgctgg gcgatgctgg cgtctcgcag tggtttgagc
    13981 gccagccgga ccagggccag tgcgttgtcg tcgccggcga tgcggttggc actgagctca
    14041 ccgcaggaca ggcaatggtg aatgatcatc cactccccgt cgggccgtac cgacatgctc
    14101 agcgcttcca ttcggccgcg gcaggtggcg gcccggtcgc cggggatccg gcggtcgacg
    14161 tgcaggctgg ccaggcagtt cgggcagtgg ttgcggtgcg tggtgccggg cgcgtccagg
    14221 gacacgtcca gtcggcagcc cacacaccgg aaatcgtgtc cttggtgccc gtgctggctg
    14281 tggaggacgt ccttgtaccg ctgcggccga cgtgctgcct gcgcgcgacg gcgggggctg
    14341 ttcactcttc ttggcatggc cggtcttctc cttccgcgtt tagaggtcgc cgaaggcttc
    14401 gagcgggaag ggcggctgtg ccagcggccg cacggccatg cgtatcaaga tgagctggtt
    14461 gtcgtcagcg cagacggggt tggaggtcag ctcgtcgcag cgcacgcaac ggtggatgac
    14521 catccagtcg ccggtgcgca gcacggcgat ggcgatcggc gacatccggc cctggcagtc
    14581 acttcggccg ccctcgacgt ggtcgagaac gtgctgggag tgcagacacg acgggcagtg
    14641 gttccgccgc gtgccgtcgc ccgcggcggc ggacacggtg agcccgcacc aggcacaggt
    14701 gaacgtgccg gtcaggatgg tgcgaggagt gcttggaaga gatttattgg tgctggacac
    14761 ccggggtgct ccttgctgag aagtctgtaa tgacagcaag agcaggccga gcggcctcga
    14821 cgaaggtgcc caccccgtac gcagcggcag acgtgccgaa aaggggcgtg ggctggatca
    14881 gagcaccgga aaatcacgtc cggtcaccgt ccgcgaggga cggcatcaat gagacggaca
    14941 gctaggcggt gcagcgaggc gcgctcggcg cgggccggaa catcaaactc ttttccaggg
    15001 cacagaaagc ccagagcaga ccaaaggaac tccgcaagag taacaacagc tccgaggcgg
    15061 gtgccaacgg attttcgggc gcctctccac cgccgtgagc agcggagaag acgtgtcctt
    15121 gggtgccgcg atctgacggc cggcgtggcg gttgtcactc ctgccggggc atccgccccc
    15181 gcagcgaccg aaacagtaca tcggggccgt cgttgatcct cttgaatggc cagcgtcgct
    15241 gtccggagag gaggaggttc aaactggcgg cccccggctg acgcagccga gcggagagct
    15301 tggtaccgcc tcgtagccga ctttcttccc ctgggggccg atcggtcacc gtccgcgagt
    15361 tacggcatca aggagacgga cggctagtgt cctgcgccgg agattcgtcg gcagaaacgg
    15421 gcgagggagt cgagaatctc ctcggccgtc ttggtccaga tgaacggctt ggggtcctcg
    15481 ttccagttct tgacccacgt gcggatgtca gcctcgaggg cctgcacgtt cttgtgtgca
    15541 ccacggcgga tcatctggtc ggccaggaag ccgaaccacc gctccacttg gttcatccac
    15601 gaggagccgg tcggggtgaa gtgcagctga aaccgcgggt gcttacccag ccacgccttg
    15661 atcgcgggag tcttgtgggt gccgtagttg tccacgatca gatggacctg gaggtgcgcg
    15721 ggcacttcct tgtcgatcct gatcaggaac ttcttgaact ccgccgcccg atgcctgcgg
    15781 tgcagggcac tgatgacctc gccggtggca acatcaaagg ccgcaaacaa ggtggtcagc
    15841 ccgttgcgga cgtagtcgtg ggtccggcgc tcgggcatgc ccggcatcat cggcaaaacc
    15901 ggctgcgacc ggtccagcgc ctggatctgg gacttctcgt ccaccgagag cacgaccgcg
    15961 ccttcgggcg gattgaagta caggccgacg acgtcgtaga tcttctccac gaacaacggg
    16021 tctgtcgaca gcttgaacgt gtctgtgaga tggggcttga gctggaactt ccgccagatc
    16081 cggccgatgg tggacttcga caggccactg tggtccgcca tcgacttccg agaccagtga
    16141 gtcgcgttct tcgggatttc ctccaacgtc gcgaccacga ctgcctccac ctgatcgaca
    16201 tcgaccgtcg gcggcctccc cggccgaggc tcgtcagcca agccgtccag tcggtcggcc
    16261 aggaaccgcc gccgccactt acggaccgtg tccgcagtca cccgcagatc ccgagcgact
    16321 gcgacgatcg gtggcacctc cggccccgca cacgccaaca caatccgtgc ccgcaaagcc
    16381 aacgcctgtg ccgacgtcgc ccgccgcatc caccgctcca acaccgcccg ctcctcatca
    16441 cagagcagca acggctccag cttcgggccc cgacgaggaa ctgacgcacc agaagaagtc
    16501 acacaacaac taacgaacaa ctactggcgc aggacactag tgtcctgcgc cggaaatccc
    16561 ggacttaagt ttctggctgg ttgttagtgt ctggtggggt gattctggag aggtagccgg
    16621 cgagggatgt gaggatctcg tcggcggatt tggtccacct gaagggtctg gggttctcgt
    16681 tccaggtgtc gatccaggcc ctgatgtcgg cttcgagggc tttgactgag gtgtggacgc
    16741 cgcggcggat gagcttgtcg gtcagcaggc cgaaccaccg ctcgacctgg ttgatccacg
    16801 aggagccggt cggggtgaaa tgcacgtgga agcgcggatg tttacccaac cacgccttga
    16861 tctctggggt gttgtgggtg gcgtagttgt cacagacgag gtgtacgtcg agtccggcgg
    16921 ggaccgcctt gtctattgtg gtcaggaact tcttgaactc gatggcgcgg tggcggcggt
    16981 ggagttcgcc gatgacggtg ccgtcggcga tgttgaaggc ggcgaacagg ctggtgatgc
    17041 cgtgccgcag gtagtcgtgc gtgcgccgtt caggcatgcc aggcatcatc ggcaggactg
    17101 gctgggatcg gtccagcgcc tggatctggg ccttctcgtc cacgcataac accactgcct
    17161 tctcgggtgg attgtgataa aggccgacga cgtcgacgac cttgtcgacg aaccgcgggt
    17221 cggtagacag cttgaagaag tcctgcaggt ggggtttgag gtcgaatttc ttccagatcc
    17281 ggccgatggt ggacttcgac agtccggtgc gggtggccat cgaggctcgc gaccagtgcg
    17341 tgtccttgcc cggtgtggac tccagcgtcg caatgacgac atcctcgacc tggtcgagca
    17401 ggatcgacgg cggccggccc accctgggct cgtcgaccag tccctccagc cggtggccga
    17461 tgaagcgggc tcgccaacgg ttcaccgtct ggtggcccac gccgagttcg gcggcaacct
    17521 gcttgttcgt cccaccctcc gcgcaccgca gcacgatctt cgcgcgcagg gccagaaact
    17581 gagcggtctt cgcccgcctc gaccaacgca ccaactgggc ccgctcagcg tcgctgagca
    17641 ccagttccgc cttgcgccgc cccgaccgcg gctcatccgc gagcccagcc acccgccggg
    17701 cagtaaaccg cgagcgccac ttcctcacag tgtccgcgga cacctcgaac tctgccgcca
    17761 cacgcgcatt cggcaacccg tccgcacagg ccaaaacaat ccgtgcccgc tcagcaagcc
    17821 gggccaccac cgccccagcc gcccaacgca gcaactccgc gcgttcctca tcggacagca
    17881 caacatcgac agcacgagga ccccgagaca tgaaaacagg ctacagactt aagtccggga
    17941 tttccggcgc atcgcactag cggtagtttg ttgacgacgg actgtgtctg cgctattgct
    18001 ccttgtagtg ggtgtggtgt catgaccgct cgtgttccgt gtccgccggc gccgggtcca
    18061 ctggaaggct atgccgctcc cttcgacgac ttgttcggca cgctggctca acgcagagga
    18121 tttcggcagt acttgacggg cttgctcgcg ccgcgggatc ggaacaagac actgacgtct
    18181 ttggcgggtg ccgagccggt cgtcggggcc cagcaccggg ccgcgcaacg tctgcagttc
    18241 ttccggtcgg agtcgacatg ggactgcgaa cggctcaacg accggcgtcc ggaacttctc
    18301 ctggacaacc cggcgaccgc gccgcacgaa cagggtgtgc tggtcatcga cgactccggc
    18361 gaccgcaagg acgggaaagc gaccgcacac gtgggccacc agtggctggg ccggtacggc
    18421 aagaccgaca acggcgtggt caccgtgacc actctgcggg ccgacgagcg catgtactac
    18481 ccactgcacg cggtgcccta caccccagcc caccacttcc ccaagggcaa aaacgacccc
    18541 gccttccgca ccaaatggcg gatcacctcc gccctgacag gccgggcgca ggccgcgggc
    18601 atcctgtccc gcgcggtggt cgcgaactac gtctacggcg acgtggacgc ctttcgcggc
    18661 gaactgagcc aggcaggagt gccgttcgcc atggccctca aacgccgtcg cggggtgtgg
    18721 gcctacggcg accagagtgg ggcagctacc tctccccgtc cggtgtcact ttcggacagc
    18781 gtgctatccc ccctgccaac ctctaccttg agggcagcaa gtcctcgtac tatgtgtatg
    18841 agttggcccg cccatggtcg gacatagcca agtacggcaa ggccggtgac atccaggccg
    18901 ggcagatcgc cccatggttc gagcagcccg gtggaggcat tcagtacaag ctccccaaac
    18961 tgacgactgc cgacggcaag tccttcgacc tcaacgtcaa gtggcttaag gagaacggct
    19021 tcctcaaggc ggggtagcgg gacaggaatc cacggggtgg gcgtcgacgt cttcgagatc
    19081 gacaccggaa tacgtcgacg ggatttccga tcgaaaccgc tccgcccatg cggggttgac
    19141 agttttcatg agctgcatct gcttggccac ccatgcgatc cgggtgtcac gctcccgggg
    19201 ccattcatga cgatgctcac gctctcagtc gctggcgatg ctggacgtcg cgtccttggt
    19261 gacctggtac atgaactcgt caagatcatc atatgtagcg tggtgaagct ctctgccgcg
    19321 ctcacgcacg atgtgatgaa tgaccccgtc cttgacctcg gcgaatgggt gcccgtccaa
    19381 ggtctgccgg aactcgacca ggtcaacagg cttgccatag aggacacggg cgacgccccg
    19441 ggcggcggcc gctatctccg acaccgtaat cgtcacactg acactataca gtgaggaagg
    19501 cccaccaccc aacgtgagca gctcccagca cagaggtgag accacagctg ggccgccgct
    19561 cccgtgacgt ctccagcgcc gcgcacgacc gcaccgaggt cgaagactgg cttgtcgacg
    19621 ccgctaccaa cattctttcg tagcatgccc gagaccagcg gagcgaagcg ggaagccgaa
    19681 gcggccacgg aaaggatggt ggcgacggag gcgctcacgg cttcgtacca ggtgagccga
    19741 cgctcgccgc gagcgagctc gtgcgtcgct cccagaagcg ccggcgccgg agcgggaacc
    19801 ggaccaccat cggtagtgac tactgaggct tgatattggg gttgacggcc cgtctggtgg
    19861 tgctatccca cggatatgga ggagatgggg ctgacgtgtg aggggcgtct gcagcgggag
    19921 aagctgcggt tgcaggctgc cgagtggttc gaagagggca tcgcccaggc agagatagcc
    19981 cggcggttgg gggcttcccg gcaggcagtg catgtctggc acaagaagtg gaagaacggc
    20041 gggacacagg cattacgttc ctcagggccg tggggcaggc gcccgctggt ctctgaggac
    20101 gaattcacac aggtcgcaga ggcgttgaag caggggcctg ccgcacacgg cttcaccgga
    20161 ggggtgtgga ccctggcccg gatccgccgg gtgatcaagg aggcgactgg tgccgagtac
    20221 accagcccgt ccggggtgtg gcggctgctg aagcgacacg gctggtcgcg gcagaccccc
    20281 acgcgccggg cctacgaacg cgatgagaag gcggtgatga cctggcggag tgaggtgtgg
    20341 ccccaggtaa aaccacagcc gagcacagcg gagcagtgat cgtcttctcg gacgaatccg
    20401 gtctgtcgct gctgccaccg gtgcgacgga cctgggcacc cgccggccag accccaactc
    20461 tgcagatgcg gatggggcag cggcccaagg tctttgtcgt cggctggtgc tgctacagcc
    20521 tcggccagcc agcccgctat ttctaccggg tcgtaccggg atcagtcacc gatcgcatcc
    20581 tgatccgcca gttacaccag gtgcaccggt ctctcggccg cccgatcgta ctgatctggg
    20641 acaacctcag cagccatcgc agccgccgga tgcgcgcgtt cgccgcccgc agccactggc
    20701 tcaccttgac ctatctgccg ccctacgcac cggacctcaa ccccgtcgaa ggcggctggg
    20761 cgcacctcaa gaacgggccg ctggccaacc tcggcgcccg aaccctcgac gaactcctca
    20821 ccaccgcccg ccgcggcctg cgacacatcc aacgtcaccc ggccctggtc acaggattcc
    20881 ttgccgcgac ccacctggac tggaacccac aaccgtcaac ctcataagca aaggtcagta
    20941 agaggacggt gagggcgtaa ggcgacgacg attcctggcg a
//
