LOCUS       NZ_CP119144            25209 bp    DNA     linear   CON 22-NOV-2023
DEFINITION  Streptomyces noursei strain C27 chromosome, complete genome.
ACCESSION   NZ_CP119144
VERSION     NZ_CP119144.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces noursei
  ORGANISM  Streptomyces noursei
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 9627936)
  AUTHORS   Go,B. and Lu,Y.
  TITLE     Control effect and mechanism of Streptomyces NK27 against gray mold
            of grape
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 9627936)
  AUTHORS   Go,B. and Lu,Y.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-FEB-2023) State Key Laboratory for Biology of Plant
            Diseases and Insect Pests, Institute of Plant Protection, Chinese
            Academy of Agricultural Sciences, Yuanmingyuan, Beijing 100193,
            China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 01-OCT-2021
            Assembly Method                   :: ABySS v. 2.3
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 98x
            Sequencing Technology             :: Complete Genomics
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 11/22/2023 14:00:30
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,442
            CDSs (total)                      :: 8,348
            Genes (coding)                    :: 8,203
            CDSs (with protein)               :: 8,203
            Genes (RNA)                       :: 94
            rRNAs                             :: 7, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 145
            CDSs (without protein)            :: 145
            Pseudo Genes (ambiguous residues) :: 0 of 145
            Pseudo Genes (frameshifted)       :: 46 of 145
            Pseudo Genes (incomplete)         :: 121 of 145
            Pseudo Genes (internal stop)      :: 12 of 145
            Pseudo Genes (multiple problems)  :: 30 of 145
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 16:17:19
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 2036616
            Orig. end                         :: 2061825
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP119144.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..25209
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="15"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..25209
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..25209
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:15209](+)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..15209
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     gene            245..1447
                     /locus_tag="P0D74_RS08905"
     CDS             245..1447
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009713729.1"
                     /locus_tag="P0D74_RS08905"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_275462216.1"
                     /transl_table=11
                     /translation="MFSIGQRIKWWRERRGLSQRMLGDLIGRSENWVYKIENDRMPLDR
                     LPILIALSKQLRCSLEDLTGGYVSEIVTAGTEHEHVPLIRQALSLPASLLPQRIGSVAS
                     DDFESSVTDAWKVYETQADDRYRDVGERLPTLLRQGHAALRDASPEQEGTVLRQLISLY
                     GLHQIWLRRVGEPTLARIAADRGLSLADNAGDPALLAAAAWNLACVLTSAGDVEDSYEL
                     AQQTIAQCRPHDDSNPEHWSAYGALHLQGAVAAVRAAKGPRAWDLYHGAQQAVARVGAD
                     LNHWHTCFGPTNFAMHEVHLKAEEGDTGEALRAADHVLVNEEVPLERRTRYLIEVMNLN
                     RIQRDDYATVHILGRLLKQSPEEIVFSPLVREAVADLLKREKPMWRDDLRAVAKHIGLA
                     A"
     misc_feature    1479..1488
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 15.26"
                     /tool="antismash"
     gene            1529..1777
                     /locus_tag="P0D74_RS08910"
     CDS             1529..1777
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="P0D74_RS08910"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_020963602.1"
                     /transl_table=11
                     /translation="MTTSHAQTGAGAASLPPAKRHLRLACEAEVAHTEAGRFAVPLDLH
                     EGAAEPATIPLVLTADEAVALHSRLGALFPFAEGDDR"
     misc_feature    1571..1573
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(1841..1857)
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: weak, score: 19.87"
                     /tool="antismash"
     gene            2013..2426
                     /locus_tag="P0D74_RS08915"
     CDS             2013..2426
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016571581.1"
                     /locus_tag="P0D74_RS08915"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ATP-binding protein"
                     /protein_id="WP_275462217.1"
                     /transl_table=11
                     /translation="MEERFSITKRSPGERPPPEDESRVSAMRLVTRERLTSRGLTCVVD
                     DATLVVSELITNAIVHSGGRQIRLTLDVCDDVLCIRVHDGVPGPRLSAQCPGDDEHGRG
                     LLLVQEIARNRQGAWGVSDNGASTWCELSLAAC"
     gene            2396..2935
                     /locus_tag="P0D74_RS08920"
     CDS             2396..2935
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF039764.2"
                     /locus_tag="P0D74_RS08920"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF6415 family natural product biosynthesis
                     protein"
                     /protein_id="WP_275462218.1"
                     /transl_table=11
                     /translation="MVRAEFGGVLMASTTVHWDERPGSAPVRVKDPSVPTNPCISPPDV
                     QDVRRVLSRLRTWEPVDWDEVYDDLDTVLGDEVSHHAAGSSVGSPLPEYDALEGLAERF
                     RPALIQLVTRGLRNGAHRKHRDIAVLIEQAQGLIPEELPADAWQAVVLLRKLARVTLGL
                     AERLEDTGIAKGLVEC"
     gene            2929..3393
                     /locus_tag="P0D74_RS08925"
     CDS             2929..3393
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016571583.1"
                     /locus_tag="P0D74_RS08925"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF6302 family protein"
                     /protein_id="WP_275462219.1"
                     /transl_table=11
                     /translation="MLITTTSTASPFTVSLRPAAEAYDFDYFRERLAEPEILAHAVAVR
                     VFRAPLLAVPVGGSRRGGYLSFDLLSLAMAARSLLKDRPGFPRLRVRWSPYRDTCHTVE
                     WGDPAPDWWVADAVAGHFYGYREEAIAAFIQKHPQTPSSATSEPYSPTAS"
     gene            3443..>3529
                     /locus_tag="P0D74_RS08930"
                     /pseudo=""
     CDS             3443..>3529
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018957768.1"
                     /locus_tag="P0D74_RS08930"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="DUF5999 family protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MCAHTPPCPTADAADRQAAQSKVHHPEQG"
     gene            3622..4434
                     /locus_tag="P0D74_RS08935"
     CDS             3622..4434
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016571584.1"
                     /locus_tag="P0D74_RS08935"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="endonuclease/exonuclease/phosphatase family
                     protein"
                     /protein_id="WP_275462220.1"
                     /transl_table=11
                     /translation="MGGVDGASEERLQKQAKILLRLNADIVCLPECNRWDEDGERRLCW
                     MADTLGLQPVAMIRSRLGTPPVQNHTALLYRPSTLRLLDRAVLGRNVFHHALIRARLRP
                     VEESDDRRDFLVLATHLSWRNGKTRLDEASWMTDYGGKFPGMPPRGILLADLNVPDREP
                     PNSDWSLIPRNMHSRYRKIREDGSFGDVDQDALQLLLNSGWQDPQTLTGVQRAPTVGYA
                     YPDEPVEWCLDYALVHGMTVTSYRTHDTPQARKASDHLPVVADVEVRP"
     gene            4431..4556
                     /locus_tag="P0D74_RS08940"
     CDS             4431..4556
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="P0D74_RS08940"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_260222713.1"
                     /transl_table=11
                     /translation="MRKVQRRGLLRNSVLPFDTGDLLPDGQDIAPVRHQAMAEAA"
     gene            4553..5020
                     /locus_tag="P0D74_RS08945"
     CDS             4553..5020
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016571585.1"
                     /locus_tag="P0D74_RS08945"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="LuxR C-terminal-related transcriptional
                     regulator"
                     /protein_id="WP_275462221.1"
                     /transl_table=11
                     /translation="MRTTTPARVTLAPRERQVLEGLADGSMLAAVALRLSIREGTASGY
                     LKGAKRKLYGVRESAAALAVGYTTKAISRPSLLDPETLLLPDNQQDIVPLLARGMTAAC
                     MAAELKRPVDIIRRDNRDLLTNLRAKNRVHAVKRLWELQLLTAGQVTAWLY"
     gene            5221..5382
                     /locus_tag="P0D74_RS08950"
     CDS             5221..5382
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="P0D74_RS08950"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_157846724.1"
                     /transl_table=11
                     /translation="MRATLREADRRLPLPPPLALPQAVVRAQGLGRLIEALDRALCLLR
                     DEEAEVFT"
     misc_feature    5227..5240
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 19.33"
                     /tool="antismash"
     gene            5379..6302
                     /locus_tag="P0D74_RS08955"
     CDS             5379..6302
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="P0D74_RS08955"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_275462222.1"
                     /transl_table=11
                     /translation="MTSSIASGLKASLRTPFAATILANRLAGSPAIWRLCRSEPSTHLW
                     QVGGPQSSVAVKVAAGERAALTLVRETENLRAMPAGNLRSLGAGSDLRPTDPIAWQITP
                     WALGLTTWEAFRLLLEGDQEGREQARAVAIETCRAVGRLHTAGWLHGTLDPHHVVHTRE
                     RSRVRLLSCAWATRAGRRTSPGYGGGLVHLLSPELANAIDRSRGNGLLLSRPAEVYTLA
                     AGLWWAVTGTWPLAYDDFRGVGFDPQTKSRPHLLRIIASGEVPRADPAVHDWPEFLEPL
                     AGAMSPSLSRRPTAHQLADWIESIPL"
     misc_feature    5730..5732
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    6144..6146
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            6492..7247
                     /locus_tag="P0D74_RS08960"
     CDS             6492..7247
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="P0D74_RS08960"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_275462223.1"
                     /transl_table=11
                     /translation="MTVAVKVASGENAARALVREAAALRTMPPGGIRVLHTADNVYCPA
                     PWAWLVTPWADGPTTWDACKKLRDTTEGGRAEARCAAVELCMAVGRLHTAGWVHGDLRP
                     HHAVHTTAGVRLLSCTGASRIGNAVSATYLGGLVHLLSPRLAAALEPTAASVMLDPDDE
                     IYTLAAGLWWAATTTWPLAYADAGLDSSTMSALALRRAIATAKIPLAKAAGHPWPEFLA
                     PLTAAMAQPPGSRPSALQLADQLKAVPLT"
     gene            7419..7862
                     /locus_tag="P0D74_RS08965"
     CDS             7419..7862
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF039985.2"
                     /locus_tag="P0D74_RS08965"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF6082 family protein"
                     /protein_id="WP_275462224.1"
                     /transl_table=11
                     /translation="MKTSHALLVLAAVGAVHVAQRERHQNQRSQVAVTQLHHSRIAQLV
                     ANPDLAQDWAPKGMDSGQFAQLLSENQQMVVLSLRHRLGLLRGKRLRFVANKIMERESG
                     RRYWKHFGADRAQEAEGNPRAQRFTEAMQTAFLAHCAAKPAGD"
     misc_feature    8220..8234
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 18.42"
                     /tool="antismash"
     misc_feature    8365..8381
                     /note="TFBS match to NtrC, Nitrogen regulatory protein C,
                     confidence: medium, score: 22.15"
                     /tool="antismash"
     misc_feature    8415..8429
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 17.3"
                     /tool="antismash"
     gene            8418..9632
                     /gene="fxlM"
                     /locus_tag="P0D74_RS08970"
     CDS             8418..9632
                     /GO_function="GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="fxlM"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PCMT"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016571590.1"
                     /locus_tag="P0D74_RS08970"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="methyltransferase, FxLD system"
                     /protein_id="WP_275462225.1"
                     /sec_met_domain="PCMT (E-value: 1.4e-38, bitscore: 131.7,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTVDTEQATTLRNTVMDQLRADGVLVTPEVEAAMRKVPRHAFAPE
                     APLEKVYEPYAAVVTKTDEYGVQISSVSAPQIQAMMLEQAKLQPGMRVLEVGSGGLNAA
                     YMAELVGDGGEVTTVDIDPEVTERGRRLLDEQGYKSVRVVTADAAEPIPGLGEVDVIMV
                     TAGAWDVPAAWLDQLAPEGRLVVPLRMRGLTRSVAFVRRGGHLESESAKICGFVPMQGA
                     TAHEVKLLLVAGSPEIGLRFDDGIPIEPSQLDNAVTTPRVELWTGVTIGRGELLDTLQM
                     HLAIGLPGFCIMVLDKELDSGIVAPTNPGFSLAAVENDSFGYVVYRRTADGENSEFGVH
                     ALGAHAQQLAEEMAQQLRTWEASRRGGPSPVIRVYPANTSDDQVHGARVIDKVHCRISL
                     SWPTH"
     gene            9683..9871
                     /locus_tag="P0D74_RS08975"
     CDS             9683..9871
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LD_lanti_pre"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016571591.1"
                     /locus_tag="P0D74_RS08975"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="FxLD family lanthipeptide"
                     /protein_id="WP_038522696.1"
                     /sec_met_domain="LD_lanti_pre (E-value: 6.8e-15, bitscore:
                     53.6, seeds: 21, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIHTALLDPTEVDGEEDFAPLDVKVVVAAHPHGKLLCATNDGCGN
                     TCANGASACTSFTEDPA"
     gene            10001..13018
                     /locus_tag="P0D74_RS08980"
     CDS             10001..13018
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003955818.1"
                     /locus_tag="P0D74_RS08980"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_275467525.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 1.9e-189,
                     bitscore: 629.9, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 1.1e-12,
                     bitscore: 47.4, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 1.2e-09, bitscore:
                     37.1, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLRATTRPGVVSLPRGLGDSAVARAWLGSVWQDADVRGALQVATP
                     VLCQAVESIVGGVQKRPRQIQRTVLSVASYLLRWQHRATPFGLFAGIAPLTVGPAALVR
                     WHGSPRATARADAAWLAEVIRQLHCHIAVVERLSVVANETAVVRGDRVVAAGPPADGRA
                     VLMAPVEVSVPARRTVLAALTAAAVPLSYRELRDQMRAQFPNACAGQVDGLLGDLIAQH
                     LLVSSLWAPMTTVDALAHVCAELKRIGAHALPGVGPLVRELDGIHATVSIEAPSSGVLV
                     DVAERMHALCDQVIAPAPLLVDTTVDGHVQIPHSVVSEVQSAVAALYRATPHPYGHTAW
                     RDYHRRFRARYGVGASVPVLDLVGDHGLGLPATYVGAEREKSVQPWTNRDEKLLARLQQ
                     VLMDGREELVLTDADIDELARVTGSEEPEFAPRLEVAFEVHAASTRELARGRFEVWVTS
                     VPRPTNSMAGRFAYLLPQEDREALARTYRPSSEETVTAQLSFTPRRHRNANISRTVQLL
                     PVLPLAEHRPDGDKEVITLADLAVTADARHLHLVQRSTGRRVELHIPHVLEAGIQTPPL
                     ARFLAEVSTVRCAVYCPFSFGAASRLPYLPRVRYRRTVLAPARWLLTATDLPARTAKMP
                     QWEEALTAWRRRMRVPARVALVELEQRLPLDLTHPVHRYLLRSRLDEAKRLELREAPEP
                     DRHGWIGRAHEILLPLRRTQPQQSLPLPAPQHPVDGANAQFPGAGVVLRAHLHSHPQRH
                     DEILDRHLPALLARFDQPPRWWFLRHREASRPEAGRHLVLVLHLPEGTYGSAADLVHAW
                     ATALHRAGLIADLTLSSYTPQTGRFGHGPALDAVHGVFAADSAAALAQIRYVAHDDALA
                     PEALTAASLLNLATHLAPTTDTGLHWLITHLPQEHGPLDRALREQTLTATQPGATFPFT
                     TTAHGTSVTVAWEARAAALAAYRSTLVGQRDPLTVLRSLLHAHHIRALGPDPKAEALTL
                     RLARTSALSHTARRTT"
     aSDomain        10415..10693
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_P0D74_RS08980_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="3.50E-15"
                     /identifier="RREFam001.1"
                     /label="P0D74_RS08980"
                     /locus_tag="P0D74_RS08980"
                     /protein_end="231"
                     /protein_start="138"
                     /score="47.4"
                     /tool="antismash"
                     /translation="VVANETAVVRGDRVVAAGPPADGRAVLMAPVEVSVPARRTVLAAL
                     TAAAVPLSYRELRDQMRAQFPNACAGQVDGLLGDLIAQHLLVSSLWAP"
     gene            13015..14244
                     /locus_tag="P0D74_RS08985"
     CDS             13015..14244
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016571593.1"
                     /locus_tag="P0D74_RS08985"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_275462226.1"
                     /sec_met_domain="LANC_like (E-value: 1.7e-43, bitscore:
                     147.7, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTKAQAAHIASRCATVLSDPRPGQNFEGQSLADGAAGIALLHIE
                     RAQARTGPWKLAHRWINHAAAGELDATDTAGLFRGVPALAFVLLNTVPHGRFHELYRTA
                     WEKLHHHVTTLAHQRTERALARIHRGELTTFAEYDLFCGLTGIGAYLLRADPTSSALEQ
                     VLRYLVALTHPVAINGHRLPGWWVAHDPNRGTSAEFAQGHANLGVAHGITGPLLLLAQA
                     LRRGVSVDGQHEAIDAICSHLDAWRQDGERGPWWPLHLTLDEFSSGRTHQRGAGRPSWC
                     YGTPGIARAGQLAGIALGDRGLQHMYEVALYLSLTDPEQLALIRDTSLCHGWAGVYQTT
                     ARAAHDSPYPHLRQLLPRLGETLTTHLRTTADHNAGLLTGNAGCALALSSLTTGAPITQ
                     TGWDACLLID"
     gene            14226..15209
                     /locus_tag="P0D74_RS08990"
     CDS             14226..15209
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016571594.1"
                     /locus_tag="P0D74_RS08990"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="thiopeptide-type bacteriocin biosynthesis
                     protein"
                     /protein_id="WP_275462227.1"
                     /sec_met_domain="Lant_dehydr_C (E-value: 6.8e-41, bitscore:
                     139.7, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPVDRLTPIDRAVLDVLAGHPLDEIARRAHMHPAHLADAVELFQQ
                     AGHDALAHQTSTLGWQQIFIEFPDWSAAESTAATLLEPVLSQAQEAGTLTGWWFIRKHP
                     CWRLRLHPRPDSTAVADVSAALDRLREHHHVKRWWPGIYEPETAAFGGALGIDTAHELF
                     VVDSREILRLPDRPDGALGRRELSVLLCSAMMRGAGLEWYEAGDVWDRVISDEGRSAAE
                     QIPEERRLQLVQQLRTLLQASTAPAGPNLAADGPLRPVATWVSAFRDTGAALGAAAHAG
                     RLERGLRHVLALHVIFHWNRIGLSHRTQSALAWSARQAVFTPLERS"
     gene            15337..15915
                     /locus_tag="P0D74_RS08995"
     CDS             15337..15915
                     /EC_number="2.-.-.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1111: GCN5-related N-acetyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016571595.1"
                     /locus_tag="P0D74_RS08995"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="GNAT family protein"
                     /protein_id="WP_275462228.1"
                     /transl_table=11
                     /translation="MEATISSGPDPILWLATDTCALGPYRADLVETYWRWEQDPALLVG
                     YGRQAPESLEARTEGMNHQLRGENIRFTIYDRTSGKPVPAGVATLLPDHAVRTAEYIVM
                     IDPQARGRGLGTQATRLTLDYAFHITNLRMVWLKVLAPNTPAIRAYERAGFRDAGLLRN
                     AGYWLGQVCDERIMDTLAEEFTGHSLVQP"
     misc_feature    16157..16172
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 18.27"
                     /tool="antismash"
     gene            16308..17054
                     /locus_tag="P0D74_RS09000"
     CDS             16308..17054
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="P0D74_RS09000"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_275462229.1"
                     /transl_table=11
                     /translation="MTREVLDGAIRRIGPPTLCGGDATGPVVRWRDDQRTLLLDHGQQA
                     LRLCVRRTSELEAEERARFAPCQQSDPVGFYTGLPYVWQLYGGGVGSPPLGFPAVPPAP
                     DWSWLEGSLAQLLSGWWEQVPVQLGYGDAVGFNIDFRGEDQHSVERVSVMCEEPGGLVL
                     LVDDRAVPGGTPEDVMRARGWRQRIMGWWQRDFEDDGADGAARAAKMVVEELLLRGARS
                     PDALKVTDVRAERGGLLALPGLAIAR"
     gene            complement(17205..18335)
                     /locus_tag="P0D74_RS09005"
     CDS             complement(17205..18335)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF037627.3"
                     /locus_tag="P0D74_RS09005"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="XRE family transcriptional regulator"
                     /protein_id="WP_275462230.1"
                     /transl_table=11
                     /translation="MLESGAHTRLKRDQCDVLSELLLLGRDEQQALVLYSTGGAGSVTP
                     APGYDSPTRRALQALLDQQMPNPTWLLDAHWNVIGYNEAMASWCPWVMEPGANLLRWAL
                     LSEEARTTFVDWSKHAVEYLAMLRFSLLQYPQNAELGALLADVTKDPELAQLWETRSEV
                     TEARGAFYYRVSLPAHNYEIVELESQTLFPAALPDCRLVILNWIQRDDSDGDTGSATRP
                     AVEEARSQPSASPLPGQVTASTADEAARYAGPGAVALPILSELIGTGCQLTYSPTNRTV
                     IWATPQHDGRWDVAEVNPYTVVVRMPQAIHVEGATAEYKLLTRAVLPAEPADAVQRIRE
                     MTAQLRRRIGILEEIHRDEWEADRSLPYGWNPVDDD"
     misc_feature    complement(18327..18339)
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 17.42"
                     /tool="antismash"
     misc_feature    18664..18677
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 19.41"
                     /tool="antismash"
     misc_feature    18700..18715
                     /note="TFBS match to CsoR, Copper-responsive repressor,
                     confidence: weak, score: 23.42"
                     /tool="antismash"
     misc_feature    19248..19261
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 15.45"
                     /tool="antismash"
     misc_feature    complement(19250..19263)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 14.43"
                     /tool="antismash"
     gene            19644..20570
                     /locus_tag="P0D74_RS09010"
     CDS             19644..20570
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016571599.1"
                     /locus_tag="P0D74_RS09010"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_233660685.1"
                     /transl_table=11
                     /translation="MSVDAREWGWEHSSSKGVARLVLLSIADRVPDEKCVAWASLASLV
                     TRTNASRTAVRTALAALAESGELELLDYLDGPQRASVYRLPHAAAWLAKVAKATKDDPD
                     AYVEPPTDSDPIPELDEEAETQLRRYGIWPKKRKDSDPSRRNPTGAESDPPRRNPPPRR
                     AGIRTAGGTDSAPQNRSEPKVNRNSSSSGAATIPVDQWQIDTATQAWAHQHGHLDRLSE
                     EGLLASDAKWRVHRANWQPRKAAAWAADWRSWIAREHSPAPGRPNLYAVPGNGGTSGAG
                     GMTRAEAHTAALLAALDESTENGAAAQ"
     gene            20567..21259
                     /locus_tag="P0D74_RS09015"
     CDS             20567..21259
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003979402.1"
                     /locus_tag="P0D74_RS09015"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_275462231.1"
                     /transl_table=11
                     /translation="MTPHEIGALLAYIGRLDPRLSRTDTGEARDQIAQWHELLGDVPPA
                     TAHGWDARVTAREHILDSPYPIMPVDIARKWRAYRRDRLQRHTDPLPSASPDDQAAWTA
                     ELRGTRLAVATGVAAPTRHRELTGSEFEPERQGQLREIGSCIPPHVREALSPYRPARAA
                     REAAIAQGQPDVLGVRCEHCHAEVNEPCRSRRLGLDGQPRANAPRSTPHPSRVDLAATQ
                     QVQQPVMA"
     gene            21405..22052
                     /locus_tag="P0D74_RS09020"
     CDS             21405..22052
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0051536 - iron-sulfur cluster binding
                     [Evidence IEA]"
                     /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019070650.1"
                     /locus_tag="P0D74_RS09020"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="WhiB family transcriptional regulator"
                     /protein_id="WP_275462232.1"
                     /transl_table=11
                     /translation="MRHITSHIAPATGLRGIADTSWHPHGACHGMAPEDADATFFPLPR
                     DHDAIEEAKELCSMCPVRQDCLNYALENRLKDGIWGGLTEAERRPWHDGLPQRLDYRRV
                     IAFFNGRDVHLTEAERQIIVDHAYVRGWRPYRLAAALKISNKHARDLLKDAANKVFDRD
                     LKLGVPPRPKQKKPQEKKTAQTQNTSHLRSGAPAKAQPVQSTSARAPHGKAA"
     gene            22049..23521
                     /locus_tag="P0D74_RS09025"
     CDS             22049..23521
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016571602.1"
                     /locus_tag="P0D74_RS09025"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_275462233.1"
                     /transl_table=11
                     /translation="MTHLSLLVDSPPDLSALLAVGAPLTAIALALTSWAIRRKGTAVKK
                     RLGDPAVVVAALAAVGCTAYSADTSWRFAADYLDIAGTLERVMLFSAAELGLFATALVA
                     RKNLATQGAPGLPGTLVWVITSVQIIPAYAESGPVGGTVRAFVGPIMAALLWHQAMGIE
                     LRLRTPGAASTGLIATLGREARQRLLSRLGIAAQARDAAQITRDRATVRAAELATRLAN
                     RAPAKRTNRHGRRLTRRLEKAIGRAEVGTDPQQRGELLGQLAARRHAPALATIPLRPPW
                     GITPQSEGAASLPPQHEHSTVVPNNGPRDEAQPLAERGPCSRRGPVPSNCGIAVEADSG
                     TGDRGAGTEPEAGNRGPSASTTGTEPTGDRGPTTPTTGTEPTGDRGHAVPLRRKPTTKP
                     KSRSNRGSRSRGPQRQRPADAPEQSVEQLVQQVRPYVPALLERDGNVAVTRVQLREILR
                     REGLKGARNDRLALVLQQLRSEDSSAKARSTR"
     gene            23518..23709
                     /locus_tag="P0D74_RS09030"
     CDS             23518..23709
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004003482.1"
                     /locus_tag="P0D74_RS09030"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_275462234.1"
                     /transl_table=11
                     /translation="MKTCTQFATIRQEYEREIRFLSAHSERHAGRPAAKSSAKHAAWTK
                     TRMARALSSHVNRCLECG"
     gene            23799..24032
                     /locus_tag="P0D74_RS09035"
     CDS             23799..24032
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016571604.1"
                     /locus_tag="P0D74_RS09035"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_275462235.1"
                     /transl_table=11
                     /translation="MQHAAIPHQFDDHLIWAFLHTFLRHGLIRSTVDGPHGQWFVQIMA
                     GGPIHHLTDTEDSCDFVLDILHIIDDVTAGEQ"
     gene            24320..24664
                     /locus_tag="P0D74_RS09040"
     CDS             24320..24664
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="P0D74_RS09040"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="plasmid mobilization relaxosome protein MobC"
                     /protein_id="WP_275462236.1"
                     /transl_table=11
                     /translation="MCNVRLSENEWQRLHAAAHITHTSLPAYLVRSGLAAAEDAQNTAA
                     AVASRRELVTELFTARRHLGQVGRNLNQVAKALNSGAWPPELDVVLAATNRAVLRVQDV
                     ADQLLAQNQD"
ORIGIN
        1 tggtgagcac accaccgaag tcgaggatca ggccacggta tggggctggc aaagcggcct
       61 ccttgccgat ctttcatgcg tgtacgcggt cccccggccg cagggcgaca gggggaccgt
      121 tgagtgccct ccccagaggg agagacctcc agtatcgccc ctccgtgaag cacgtgggcc
      181 tacgcttgac acgagtgccc tgtccactac ggcgaacggt caacccatgg tgtatgacgg
      241 agagttgttc agcatcggcc aacggatcaa gtggtggcgg gagcgccggg gcttgtccca
      301 aaggatgctg ggagacctaa tcggcaggtc agagaactgg gtctacaaga ttgagaacga
      361 ccggatgccg ctggaccggc ttccgatcct gatcgccctg agtaagcagc tgcgatgcag
      421 tctggaggac ctgacgggcg gctacgtgtc cgagatcgtt acggcgggga cggagcacga
      481 gcacgtgccg ctcatccgac aggccctttc gctgcccgcc tccctccttc cgcagcgcat
      541 cgggtcggtc gcctccgatg acttcgagtc gtcggttacg gacgcttgga aggtctacga
      601 gacgcaggct gatgaccggt accgcgacgt cggcgagcgg ctgcctaccc tgttgcggca
      661 aggacacgcc gctctgcgcg acgcctcgcc tgagcaggag ggcacggtcc tccggcagct
      721 catcagcctc tacggcctgc accagatctg gcttcgtcgc gtcggtgaac cgaccctcgc
      781 ccgaattgcg gccgaccgcg gcctctccct cgcggacaac gccggtgacc cggccctcct
      841 cgcggctgcg gcctggaacc tggcctgcgt tctcacttcc gctggagatg tggaagacag
      901 ctacgaactc gcccagcaga ccatcgccca gtgccggccg cacgacgact ccaacccgga
      961 gcactggtcc gcgtacggcg cactgcactt gcaaggtgcc gtcgctgccg tacgcgctgc
     1021 aaagggcccg agggcgtggg acctgtacca cggggcacag caggccgtag cccgggtcgg
     1081 cgcagacctc aaccactggc acacgtgctt cgggccgacc aacttcgcca tgcacgaggt
     1141 acacctgaag gcggaggaag gcgacaccgg cgaagcactc cgcgccgccg atcacgttct
     1201 tgtcaacgaa gaggtcccgc tcgaacgtcg gacccggtac ctgattgagg taatgaacct
     1261 caaccgcatc cagcgagacg actacgcgac ggtgcacatt ctcggcaggc tgctgaaaca
     1321 gtctccggag gagatcgtgt tctctcccct ggtcagggag gcggtagccg acctgctaaa
     1381 gcgcgagaag ccgatgtggc gcgacgacct gcgtgcggta gcgaagcaca tcgggctcgc
     1441 cgcataggca tatgccaacc ctgagcgtta ctcagccctg attttttctc agggatgggg
     1501 cttcgaagtg gccctacttt tacgggtcat gacgacaagt cacgctcaga cgggagccgg
     1561 cgcggcgtct ttaccgcccg ccaagcgcca cctccgcctt gcttgcgagg ccgaggtcgc
     1621 gcacacggag gccggtcgtt tcgcggtccc cctcgacctg cacgaggggg ccgcggagcc
     1681 cgcgaccatt ccgctggtcc tgacggccga tgaagcggtt gctctgcaca gcaggctcgg
     1741 tgccctcttc cccttcgcgg aaggggacga ccgatgaccg cccgaactcc cgccgatcgc
     1801 gagcgacgcc gcaacctagc ggacgcctcg aacactccgt tgcccgcttt tgccgcgctg
     1861 cttctacacg taccgggcca gcggcgccgg aggggccctc tcgcttccct caacgaccgg
     1921 gccgccccgg aagacggggc ctcgcggatc gggacggagc ggtgatcggc tcggcgccac
     1981 ggcgcccgac cgcggctcgt accggcggct tggtggagga gcgcttctcc atcaccaagc
     2041 gctccccggg tgagcgcccc cctcccgaag acgagtcccg cgtcagcgcc atgaggctcg
     2101 tgacccgcga acgtctcacc tcccgcggtc tgacctgcgt cgtcgacgac gcgacactcg
     2161 ttgtctctga gttgatcact aacgccatcg tgcacagcgg tggcaggcag atccggctga
     2221 cccttgacgt gtgcgatgac gtcctgtgca tccgtgtcca tgacggcgtg ccgggacctc
     2281 gcctctctgc tcagtgcccc ggggacgacg aacacggtcg cggcctgctg ctcgtgcagg
     2341 agatcgcgcg gaacagacag ggtgcttggg gtgtcagcga caacggcgcc agcacatggt
     2401 gcgagctgag tttggcggcg tgctgatggc gagcaccact gttcactggg atgagcggcc
     2461 cgggtcggcg ccggtacggg tcaaggaccc gtcggtcccg acgaacccct gcatctcacc
     2521 gcccgacgtg caggacgttc gtcgggtgct gtccagactg cgcacatggg aaccggtgga
     2581 ctgggacgag gtctatgacg acctggacac ggtcctgggc gacgaagtca gtcaccacgc
     2641 cgcgggttcc tcggtcgggt ctcctctgcc tgagtacgac gcccttgaag ggctggcgga
     2701 gcgcttccgg ccggctctca ttcagctcgt gaccagaggt cttcgaaacg gcgcccacag
     2761 aaagcaccgg gacatcgcgg tcctgatcga gcaggcgcaa gggctgatcc cggaggagct
     2821 gcccgccgac gcatggcagg ccgtcgtgct cctgcggaag ctagcgcggg tcacgctggg
     2881 tctcgccgaa cgcctggaag acaccggcat cgccaagggg ctggtcgaat gctgatcaca
     2941 accacatcga cggcgagtcc cttcacggtc tccctccgcc ctgctgcgga agcctatgac
     3001 ttcgactact tccgcgaacg cctcgccgag cccgagatcc ttgcccatgc cgtggctgtc
     3061 cgcgtctttc gagcgccgct gctcgccgta ccggtcggag gctcccgccg tggcgggtac
     3121 ctgtccttcg atctgctgtc gctggcgatg gcagcccgca gtctgctcaa ggaccggccg
     3181 ggctttccgc ggctccgtgt ccgctggtcg ccgtaccgcg acacctgcca caccgtcgag
     3241 tggggcgatc ctgctcccga ttggtgggtg gccgatgcgg tcgcgggtca cttctacggc
     3301 taccgcgagg aagcaatcgc cgcgttcata cagaaacacc cacagacacc ctcttcggcc
     3361 acctccgaac cgtattcccc cacggcctcg tagcccgccg aagagggccc aacttcccgc
     3421 ccgcaccgag aggacgaaca ctatgtgcgc gcacacccca ccgtgtccca cggctgatgc
     3481 ggccgacagg caggccgcgc agtccaaggt ccaccaccct gagcagggcc ggcgtgctaa
     3541 ctgcaccaac cctctgcgcg gaacgctcat ccaccgcagg agggacggcg cgtgatgcga
     3601 gccgttatct ggaatttgta cttggggggc gtagatggcg cctcagagga acgcctccag
     3661 aagcaggcga agatcctgct caggctcaac gccgacatcg tgtgcctgcc ggaatgtaac
     3721 cgatgggacg aggacggtga gagacgactg tgctggatgg cggacaccct gggcctccag
     3781 cccgtggcca tgatccgatc tcgactgggc acaccccccg tccagaacca caccgcgttg
     3841 ctgtaccggc cgtccacgtt gcggctcctg gacagggcag tcctgggaag gaatgtattc
     3901 caccacgctc tgatcagagc ccggctgcgc cctgtcgaag agtccgacga ccggcgcgac
     3961 ttcctcgtcc tcgccaccca cctcagttgg aggaacggta agacgcggct ggacgaggcc
     4021 agctggatga ccgactacgg cggcaagttt cccggcatgc cgccccgagg catcctgctg
     4081 gcggatctga acgtccccga ccgggaaccg cccaactccg actggtcgct catcccgcgg
     4141 aacatgcact cccgataccg aaagatccgc gaagacggct cgtttggcga tgtggatcaa
     4201 gacgcgctcc agctgctgct caactctggc tggcaggacc cgcagacact cacgggtgtg
     4261 cagcgagctc ccaccgtcgg atatgcctac cccgacgagc cggtggagtg gtgcctggac
     4321 tacgccctag tccatggcat gaccgtgacg tcgtaccgca ctcatgacac accccaggca
     4381 cgtaaggcat cggaccacct gccggtcgtg gccgacgtgg aggtacggcc atgaggaaag
     4441 tgcagagaag gggcctgctg cgcaacagcg tcctgccctt cgacaccggt gatctgctgc
     4501 ctgacgggca ggacatcgcc ccggtgcggc accaggccat ggcggaagcg gcatgagaac
     4561 cacgacccca gcaagggtca ccctcgcacc cagggagcgg caagtccttg agggcctcgc
     4621 cgacggcagc atgctcgccg cggtcgcact gcgcctctcg atccgggagg gcacagcttc
     4681 gggctatctc aagggcgcca agcggaagtt gtacggcgtg cgcgagagcg ccgccgcgct
     4741 cgccgtcggc tacaccacca aggccatctc ccgaccctca ctgctggacc ccgaaaccct
     4801 gctcctgccc gataaccagc aggacatcgt gccgctcctc gcccgcggca tgacggcggc
     4861 gtgcatggcc gccgaactga agcggccagt cgacatcatc cgaagggaca accgcgacct
     4921 cctgaccaac cttcgggcta aaaatcgcgt ccacgccgtc aagcggttgt gggagctgca
     4981 gctcctgact gcggggcagg tgaccgcatg gctgtactga ttcgtcctgc tgctgatggg
     5041 gacgaggtcc tctcgctcat cactgtggcg gccgcctgga cgccgcgggg ctctgaagtc
     5101 ccggatgggg agactgttcg ggaggcgatc ggccggctca ccgtgcacgg acgcgaccgg
     5161 tcagcctgtc tgcgagtcct actcggcagg tgcagcatcc aggagcccga gcttgcccgt
     5221 gtgcgtgcca cgctccgcga agccgaccgg cgcctcccgc ttccgccgcc cctcgccctc
     5281 ccacaggccg tggtccgggc gcagggcctc ggccggctca tcgaggctct ggaccgtgct
     5341 ctgtgcctgc tccgtgacga agaggcggag gtcttcacgt gaccagcagc atcgcctccg
     5401 gtctcaaggc gagcctgcga actccgttcg ccgccaccat cctcgcaaac cggcttgccg
     5461 gctcccctgc gatctggcga ctgtgccgta gcgagcccag cacccacctg tggcaggtag
     5521 gcggcccgca gtcgtctgta gcggtcaagg tcgccgcagg cgagagggca gccctgacct
     5581 tggtacggga aaccgagaat ctgcgcgcca tgcccgccgg gaacctccgg tccctgggag
     5641 ccggttccga cctgcgcccg acggatccga tcgcctggca gataaccccg tgggcgctcg
     5701 gcctgacgac ctgggaggca ttccgcctct tactcgaagg ggaccaagaa ggccgcgaac
     5761 aggctcgggc ggtcgccatc gagacgtgcc gggccgtcgg ccgcctgcac acggccggct
     5821 ggctgcacgg cacactcgac ccgcaccacg tcgttcacac ccgtgagcga agccgagtcc
     5881 ggctgctgtc ctgcgcctgg gcaacccgcg ctggcagacg gaccagcccc ggctatggcg
     5941 gcggcctggt gcatctgctc tcgcctgaac tggccaacgc gatcgaccgg tcccgcggca
     6001 acggactgct cctgagcaga ccggcggagg tctacaccct ggctgctggg ctgtggtggg
     6061 cggtcaccgg tacgtggccg ctggcctacg acgacttccg cggcgtcgga ttcgatccgc
     6121 agacgaagag ccgtcctcac ctcttacgca tcatcgcgag cggagaagtc cctcgcgccg
     6181 atcccgccgt gcacgactgg ccggagttcc tggaaccgct ggccggggcg atgtccccct
     6241 cgctgagccg ccggcccaca gcccatcaac tcgccgactg gatcgaatcg attcccctct
     6301 gaccagccag ccgacctcag ccctctcgac atgtttcatt acggagcccc atgaccacct
     6361 caaccacacc gtcccttcat tgccctgaca ccgccagcga ctacgccagc caatgcgctg
     6421 gttcccccgc aacctgggcc ctgatccgcg accgccacga tcaccagctc tggcaggtcc
     6481 atggcccacg catgacggtc gccgtgaagg tcgccagcgg cgaaaacgcc gcccgcgccc
     6541 tggtgcgcga agccgccgcc ctccggacca tgccgccggg aggaatccgc gtcctgcaca
     6601 ccgctgacaa cgtctactgc cccgcgccct gggcctggct ggtcaccccc tgggccgacg
     6661 gccccaccac gtgggacgcg tgcaagaagc tgcgcgacac cacggaagga gggcgcgccg
     6721 aagcacgttg tgctgcggtc gagttgtgca tggccgtggg gcgtctccac actgccggct
     6781 gggtccacgg cgaccttcgc ccccaccacg cggtccacac caccgcaggc gtccggctgc
     6841 tgtcctgcac cggcgcctcg cggatcggca acgccgtctc cgccacctac ctcggcggcc
     6901 tggtgcactt gctctccccg cgactcgccg ccgcgctgga gcccacggca gccagcgtga
     6961 tgctcgaccc cgacgacgag atctacaccc tggccgccgg cctgtggtgg gccgccacca
     7021 ccacctggcc cctcgcctac gccgacgccg gcctcgactc cagcaccatg agcgcgctcg
     7081 ccctgcgtcg agccatcgcc acagccaaga tccccctggc caaggccgct ggccatccct
     7141 ggccggagtt cctcgcaccg ctcaccgccg cgatggcgca gccgcccggc agccgcccca
     7201 gcgcccttca gctcgccgac cagctcaaag ccgtgccgct cacctgacgg aggacagaag
     7261 tagtcggtca ccactgtgac acttgatctt ctccgtccaa cccgtcgctg cgatttgacc
     7321 ggaccacggg ctccgcctcg gctgcagcca tcgggcgggc cgcctcgtgg cgctcgtcct
     7381 gcctcgcacc ggaccacacc gtgatggaag gaatcgctat gaagacctcg catgctctcc
     7441 ttgtcctcgc cgccgtcggg gcggtccacg tcgcacagcg agaacggcac caaaaccagc
     7501 gcagtcaagt ggcggtgacc cagctccacc acagccgcat cgcccagctg gtcgccaacc
     7561 cggacctcgc ccaggactgg gcgcctaagg ggatggacag tgggcagttc gcgcagctgc
     7621 tgagcgagaa ccaacagatg gtcgtgctct cgctccggca ccgactgggc ctgctccgcg
     7681 gcaagcgact gcgcttcgtg gcgaacaaga tcatggagcg agagagcggc cggcgctact
     7741 ggaagcactt cggcgccgat cgtgcacagg aagcggaagg caacccgcgc gcccagcgct
     7801 tcaccgaggc tatgcagacc gccttcctcg cccactgtgc ggcgaagccc gccggcgact
     7861 gaaccccacc gaagcacccc gacattcagc agttgcgtgc ggactgcacc gcactgcgga
     7921 accaccactt cgaaaggaca tcgtgggcaa aggcaaaggc agggacacca tccgggtggc
     7981 gaaggccgct ggtgacaggg acaacaacgg ccgaggcaaa gcccaacggc aagaagtact
     8041 cggcacccga tactcccggc agacccacat ctgtaagaag tactgcgaca agccgtgccc
     8101 gctgaacccg gacagctagc ggtctcactc caccggttct gctccacccc ggacccacac
     8161 cgggttcggg tgcacctccc gccgccggtc ctggcacaag gctcggcgcc ggaaagtggg
     8221 gatcggttcg gcctctcccc acatcaccga catgcgtcaa cgtgaaggag atctgcctct
     8281 gctcgatggc ctcatctcag ccactgtcgg tgagcaccgc acaacgcggt gtccgaatca
     8341 atagcgtcgt ccgcagccgg cttctgcact gttccggtgc ctgccggctt tccagaaacg
     8401 cactacgaag gatcgtcatg accgtcgata ccgagcaggc cacgacactg cgcaacaccg
     8461 tgatggacca gctacgagcg gacggcgtgc tcgtcacgcc ggaggtcgag gcagcgatgc
     8521 gcaaggtccc gcgtcacgcc ttcgctcctg aggcacccct cgaaaaggtc tacgagccct
     8581 acgcggcagt cgtcacgaag accgacgagt acggcgtgca gatcagcagc gtctccgctc
     8641 cgcagatcca ggccatgatg ctggaacaag ccaaactgca gccgggcatg cgggtgttgg
     8701 aggtcggctc cggtggcctg aacgccgcct acatggccga gttggtgggt gatggcggcg
     8761 aggtcacgac ggttgacatc gaccccgagg tcaccgagcg gggccggcgc ctgctggacg
     8821 agcaggggta caagagcgtc cgcgtcgtca ccgccgatgc cgccgagccg atccccggtc
     8881 tgggagaggt cgacgtcatc atggtcaccg ctggggcctg ggacgtccct gcggcctggc
     8941 tcgatcagct cgctcccgaa ggccggctgg ttgttcccct gcggatgcgg ggactgaccc
     9001 gttccgtcgc cttcgtccgc cgcggtgggc accttgagag cgagtcggcg aagatctgcg
     9061 gcttcgtgcc gatgcagggc gccaccgccc acgaggtgaa gctgctcctg gtcgctggca
     9121 gccccgagat cggtctgcgg ttcgacgacg gcatcccgat cgagcccagc cagctcgaca
     9181 acgcggtcac cacgccgcgg gtcgagctgt ggaccggcgt caccatcggg cgtggggaac
     9241 tgctggacac acttcagatg cacctggcca tcgggctgcc gggcttctgc atcatggtgc
     9301 tggacaagga gctcgactcc ggcatcgtcg ccccgaccaa ccccggcttc tccctggctg
     9361 ccgtggagaa cgacagcttc ggctacgtcg tctaccgccg caccgcggac ggcgagaact
     9421 ccgagttcgg cgtccacgcc ctgggggccc acgcacagca actcgccgag gagatggcgc
     9481 agcagctgcg tacttgggaa gccagccgcc gcggcggccc cagcccggtc atccgggtct
     9541 atccggccaa caccagcgat gaccaggtcc acggtgcccg ggtcatcgac aaggtgcact
     9601 gccggatctc gctctcctgg cccactcact aatcgcaggg ccaggtcgtc atgcaccact
     9661 ccatcactga aggggaggat tcatgattca caccgcgctg ctcgatccga cggaggtcga
     9721 cggtgaggag gactttgcgc cgttggacgt gaaggtcgtc gtcgccgccc acccgcacgg
     9781 caagttgctc tgcgccacca acgacgggtg cggaaacacg tgcgccaacg gggcttcggc
     9841 ctgcacgtcg ttcacggagg acccggcctg atcggctcct cgctggtgtg ccgggctcat
     9901 cagcccggca caccagcact tctggtcatg cctgcctacc gtcgaaggag cctgcgtgcc
     9961 cgctttccct cctgtgacct atgagtacgg cggcggcgcc atgttgcgcg ccaccacacg
    10021 ccccggcgtc gtcagcctcc cgcgcggcct gggggactcg gccgttgccc gtgcgtggct
    10081 gggcagtgtc tggcaggacg ctgacgtgcg gggtgctttg caggtggcta ctcccgtgtt
    10141 gtgccaggca gtcgagagca tcgtgggtgg ggtgcagaag cggccacggc agatccagcg
    10201 gaccgtgttg tcggttgctt cctacctgct gcggtggcag caccgcgcca ccccgttcgg
    10261 cctgttcgcc ggcattgccc ccctgacggt aggcccggct gcgctggtgc ggtggcacgg
    10321 gtcgccgcgc gccacggccc gtgccgatgc cgcctggctg gctgaggtga tccgccaact
    10381 gcactgtcac atagccgtgg tggagcggct ctcggtcgtg gcgaacgaga ccgcagtcgt
    10441 acgcggagat cgggttgtgg ccgcgggccc gcccgctgac ggccgcgcgg tgctgatggc
    10501 acccgtggag gtgtccgttc ccgcgcggcg caccgtcctc gccgccttga ccgctgccgc
    10561 cgtgcccctg tcctacaggg aactgcgcga ccagatgcgc gcccagttcc ccaacgcctg
    10621 cgccgggcag gtcgatggtc tgctcggtga tctcatcgcg cagcacctgc tggtctccag
    10681 cctgtgggcc ccgatgacca ccgttgatgc cctggcccat gtctgtgccg agctgaagcg
    10741 gatcggtgcg cacgccctcc ccggcgttgg ccctctggtg cgcgagctgg acggcatcca
    10801 cgccaccgtc agcatcgaag cgccctccag cggcgtgctg gttgatgtgg ccgagcggat
    10861 gcacgccctc tgcgaccagg tcatcgctcc ggcgcccctc ctcgtcgaca cgacggtgga
    10921 cggccacgtg cagatccccc actccgtcgt gtccgaagtt caaagcgcgg tggccgcgct
    10981 gtaccgggcc accccgcacc cctacgggca cacggcatgg cgcgactacc accggcgttt
    11041 ccgtgctcgc tacggtgtcg gcgcatccgt gccggtcttg gacctggtcg gcgatcacgg
    11101 gctgggcctg ccggccacct acgtcggagc cgagcgtgag aagtcggtcc agccgtggac
    11161 gaaccgcgac gagaagctgc tggcgcgcct tcagcaggtc ctcatggacg ggcgcgagga
    11221 gctggtgctg acggacgcgg acatcgatga gttggcccgc gtcaccggct ccgaggagcc
    11281 ggagttcgct ccccggctgg aagtggcctt cgaagtccac gcggccagca cccgggagct
    11341 ggcccgcggc aggttcgagg tgtgggtcac cagcgtcccc cggcccacca acagcatggc
    11401 tggccgattc gcctacctcc tgccccagga ggaccgcgaa gccctcgcgc gcacctaccg
    11461 tccttcctcg gaggagacgg tgaccgcgca gctcagcttc accccgcgcc ggcaccgcaa
    11521 cgccaacatc tcccgcaccg tgcagttgct gcccgtcctc ccgctggccg agcaccgccc
    11581 ggacggcgac aaggaggtga tcaccctcgc ggacctcgcc gtcactgccg atgcccgcca
    11641 cctgcacctg gtacagcgct ccaccggccg gcgggtggaa ctgcacatcc cccacgtgct
    11701 ggaagccggc atccaaacgc ccccgctggc gcggttcctc gccgaagtct ccaccgtccg
    11761 ctgcgccgtg tactgcccgt tctccttcgg cgcagccagc cggctgccct acctgccacg
    11821 ggtccggtac cgccgaaccg tcctggcacc ggcccgctgg ctcctcaccg caaccgatct
    11881 tcccgcccgc acggccaaga tgccgcaatg ggaagaagcg ttgactgcct ggcgtcgccg
    11941 tatgcgcgtg cctgctcggg ttgcgctggt cgagctggag cagcgtcttc ctctggacct
    12001 gacgcatccc gtccatcgct acttgctgcg gtcccgcctc gacgaggcca agcgtctcga
    12061 actgcgcgag gcccctgagc cggaccgaca cgggtggatc ggccgtgccc acgagatcct
    12121 gctcccccta cgtcgcaccc agccgcagca aagcctcccg ctcccagcac cccagcatcc
    12181 ggtcgacggg gccaatgccc agtttcccgg cgccggagtg gtgctccgcg cgcaccttca
    12241 cagccatccg cagcggcacg acgagatcct cgatcgccac ctgcccgctc tcctggcgcg
    12301 cttcgatcaa ccgccgcggt ggtggttcct acgacaccgt gaagcctccc gccccgaagc
    12361 cggccggcac ctcgtccttg tcctgcacct gcccgaggga acctacggct cggcggccga
    12421 cctcgtgcac gcctgggcta ctgccctgca ccgtgccggc ttgatcgccg atctcacctt
    12481 gtccagctac accccgcaga cgggccgttt cgggcacggc ccagctctgg acgccgtcca
    12541 cggcgtcttc gccgccgact ccgccgcagc cctggcccag atccgctacg tcgcccatga
    12601 cgacgcgctc gcgccggagg cgctcacggc cgccagcctg ctcaacctcg ccacccatct
    12661 cgcccccacc accgacacgg gcctgcactg gctcatcacg catctcccgc aagagcacgg
    12721 cccgttggac cgcgcccttc gcgaacagac cctgaccgcc acccaacccg gcgcgacctt
    12781 cccgttcacg acgacggcac acggcacgtc ggtgaccgtg gcgtgggagg cccgcgccgc
    12841 agccctggct gcctaccgca gcaccctggt cggacaacgc gacccgctca ccgtgctgcg
    12901 ctccctgctc cacgcccacc acatccgcgc cctcggcccc gacccgaagg ccgaagccct
    12961 caccctccgc ctggcgcgca cctcagccct cagccacacc gcccggagaa ccacatgacc
    13021 accaaagccc aagccgcaca catagccagc agatgcgcca ccgttctctc cgacccacgc
    13081 cccggtcaga atttcgaagg gcagtcgctg gccgacggag cagccgggat cgcgctgctg
    13141 cacatcgagc gcgcccaggc ccgaacgggg ccttggaagc tggcgcaccg ctggatcaac
    13201 catgccgccg ccggcgaact cgacgccacc gacaccgccg gcctgttccg cggtgtcccc
    13261 gccctcgcct tcgtcctgct caacaccgtg ccccacggcc gcttccacga gctctaccgc
    13321 actgcgtggg agaaactcca ccaccacgtc accaccctgg cccaccaacg caccgaaaga
    13381 gcactcgccc ggatacaccg cggcgagctg accaccttcg ccgagtacga cctcttctgc
    13441 ggcctgaccg gcatcggcgc ctacctcctg cgtgcagacc ccaccagcag cgcactggaa
    13501 caggtcctgc gctacctcgt cgccctcacc caccccgtgg ccatcaacgg ccaccggctg
    13561 cccggctggt gggtcgcaca cgaccccaac cgcggcacca gcgcggaatt cgcccaaggc
    13621 cacgcgaatc tcggggtggc acacggcatc accggccccc tgctgctcct cgcccaagcc
    13681 ctgcgtcgcg gcgtcagcgt cgacgggcaa cacgaggcca ttgacgccat ctgctcccac
    13741 ctcgatgcct ggcgacagga cggggaacgc ggcccctggt ggccactgca cctcaccctg
    13801 gacgagttct cgtccggtcg gacacatcaa cgtggagccg gccgcccgag ctggtgctac
    13861 ggcacccccg gcatcgcacg cgccggccaa ctcgccggca tcgccctggg cgaccgcggg
    13921 ctccagcaca tgtacgaggt cgcgctctac ctgtccctga ccgacccgga gcaactcgcc
    13981 ctcatccgcg acacctcgct ctgccacggc tgggccggcg tctaccaaac cacggcccgc
    14041 gccgcccacg acagccccta cccccacctg cgtcagctgc tgccccgctt gggcgaaacc
    14101 ctcaccactc acctccgcac aacagccgac cacaacgcgg gactactgac gggcaacgcc
    14161 ggatgcgccc tcgccctgtc ctcgctgacc acgggcgctc cgatcactca gacgggatgg
    14221 gacgcatgcc tgttgatcga ctgaccccca tcgaccgcgc cgtcctcgac gtcttggccg
    14281 gccaccccct ggacgaaatt gcccgacggg cgcacatgca tccggcacac ctggcggacg
    14341 ccgtcgagct gttccaacag gctggacacg atgccctcgc acaccagacc agcaccctcg
    14401 gttggcagca gattttcatc gagttcccag actggtccgc cgccgaatcc accgcagcca
    14461 cccttctgga acccgtactg agccaggctc aagaagccgg caccctcacc ggctggtggt
    14521 tcatccgcaa acacccctgc tggcgcctgc gcctccaccc tcgccccgac tccaccgccg
    14581 tagccgacgt cagcgcggca ctcgaccggc tacgggagca ccatcacgtg aagcgatggt
    14641 ggcccggcat ctacgaaccg gagaccgcgg ccttcggcgg cgccctcggt atcgataccg
    14701 cccacgaact gttcgtcgtc gacagccgcg aaattctccg cctgcccgat cgcccagacg
    14761 gcgccctcgg ccgccgcgag ctctccgttc tcctgtgctc ggccatgatg cggggcgctg
    14821 gcctggaatg gtacgaagcc ggcgatgtct gggaccgcgt catcagcgac gagggccgtt
    14881 ccgcagccga gcaaatcccc gaagaacgcc gcctgcaact ggtccagcag ctccgcaccc
    14941 tgctccaggc cagcaccgcc ccggcgggcc caaacctggc cgccgacgga cccctccgcc
    15001 cagtcgccac ctgggtatca gccttccgcg acacaggcgc agcgctcggc gccgcagccc
    15061 atgccggacg actcgaacgc ggcctccgac acgtcctcgc cctccacgtc atcttccatt
    15121 ggaaccgaat cggtctatcc caccgaaccc agagcgcctt ggcatggtcc gcccgacaag
    15181 ccgtgttcac cccgctagaa cgcagttagg cacgctgaca gttctgcggc gttacgaagc
    15241 aggggcagcc tcgaaccatc gcaatgcccc tggctacgga cggcaccccc gtcgaagagc
    15301 cgccctcgac gttcgcctac accccggcac tcaccattgg aggccaccat cagctccggc
    15361 cctgacccca tcttgtggct cgccaccgac acctgcgcgc tcggccccta ccgcgccgac
    15421 ctcgtcgaaa cgtactggcg ctgggaacaa gaccccgccc tgctcgtcgg ctacggacgc
    15481 caagcccccg agtccctgga agcacgaacc gaaggcatga accaccagct ccgcggcgag
    15541 aacatccgct tcaccatcta cgaccgcacc tcgggcaaac ccgtacccgc cggcgtcgcc
    15601 accctcctgc ccgaccacgc cgtccgcacc gccgaataca tcgtcatgat cgacccccag
    15661 gcccgcgggc gcggcctggg cacccaagcc acccgactca ccctcgacta cgccttccac
    15721 atcaccaacc tgcgcatggt ctggttgaaa gtgctcgccc ccaacacacc agccatccgc
    15781 gcctacgaac gggcgggctt ccgtgatgca gggctcctcc gcaacgccgg ctactggctc
    15841 ggacaggtct gcgacgagcg gatcatggac accctcgccg aagagttcac aggccactct
    15901 ctcgtgcagc cctgaagctg tgccgacata agaccctgcg gtgcgggcac cggcccgccc
    15961 gacccgcaac tcgtgcacgt cgctgacagc accgcgaggc tcgacgagta ggacgtacgg
    16021 tcaaacccgc gccgccatgc gcaggccctc cgcggagccc ctcgcatgtc cgcggccaag
    16081 cccctccgga agccttcgcc cgcctgccca gctacgcgtc cttcgttcgt gttgccggat
    16141 cgcttcccgc acccaaaatt acacatatgg acgaaatggg tcctggaggc ggcataggcg
    16201 acctggccgt gcacctgcac gatcacccta cgaatggtga ctttcaggca gcacccgtaa
    16261 ctctctacga gtacagcggt ggagttccgg tcacgcgccg aaggagcatg acccgtgaag
    16321 tcctcgatgg cgcgatcaga cggatcggcc cgccgacgct atgcgggggc gatgccaccg
    16381 gtccagtagt gcggtggcgc gacgatcaac ggacgctcct actcgaccac gggcagcagg
    16441 cgctacggct ctgcgtgcgg cgtacgtcgg agttggaggc cgaggaacgc gcgagatttg
    16501 ccccttgcca gcaatcggac ccggtggggt tttacacagg actgccttac gtgtggcagc
    16561 tgtatggcgg tggcgtgggg agcccgcctc ttgggtttcc ggccgtaccg cctgctcccg
    16621 attggtcgtg gctggagggt tcgctggccc agttgctcag tggctggtgg gagcaggtcc
    16681 cggtgcagct tgggtacgga gatgcggtcg gtttcaacat cgattttcgc ggcgaagatc
    16741 agcactccgt cgagcgggtc tcggtgatgt gcgaggagcc cgggggcttg gtgctgctgg
    16801 ttgacgaccg cgccgtgccg ggtggtaccc ccgaggacgt gatgcgggca aggggatggc
    16861 gccagcgcat catgggctgg tggcagcggg acttcgagga cgacggcgcg gacggagcgg
    16921 ccagggccgc caagatggtc gtcgaggagt tgcttctacg gggagcccgg tcacccgatg
    16981 ccttgaaggt gacggacgtg cgggccgaga ggggtggcct gctcgctcta cccggtctcg
    17041 ccatcgcccg atgacgagac cacccgcgac tggtgagccc gccaccatga cctgatcttg
    17101 ttccgcagtt cagcggcctc gattccctcg tgctggccgg cgcttcgcag cgagcacgag
    17161 ggctcaaatc gcctcggaga tcctaacgat ccgtgcggtg tgggtcagtc gtcgtcgacg
    17221 gggttccacc cgtacggcag gctgcggtcg gcttcccact cgtcgcggtg aatctcttcg
    17281 aggatcccga tgcgtcgtcg cagctgggcc gtcatctcgc ggatccgctg gacggcgtcg
    17341 gcgggctcgg ctggcagcac ggcgcgggtg agcagtttgt actccgccgt cgcgccctcg
    17401 acgtggatgg cctgcggcat acggacaacc accgtgtagg ggttcacctc ggcgacgtcc
    17461 caccggccgt cgtgctgggg ggtggcccag atgacggtgc ggttggtggg ggaataggtc
    17521 agctggcagc cggtgccgat cagctcgctc aggatcggca gcgcaacggc gcccgggcca
    17581 gcgtatctcg cggcctcgtc cgccgtgctg gccgtgactt ggccgggcag cgggctggcc
    17641 gagggctgcg agcgcgcctc ctcgaccgcg ggccgcgttg cggaaccggt gtcgccatcg
    17701 gagtcgtcgc gctggatcca gttcaggatg accaggcggc agtcgggaag ggcggcaggg
    17761 aagagcgtct ggctctccag ctcgacgatc tcgtagttgt gcgccggcag ggacacccgg
    17821 tagtagaagg cgccccgcgc ctcggtgacc tcggaccttg tctcccacag ctgggcgagt
    17881 tcggggtcct tggtgacgtc cgccagcagg gctccgagtt cagcgttctg cgggtactga
    17941 agcagggaga agcgaagcat cgccaggtac tcgaccgcgt gcttggacca gtcgacgaag
    18001 gtagttcggg cttcctcact cagcagcgcc caacgcagca ggttggcgcc gggctccatc
    18061 acccacgggc accaggacgc catcgcttcg ttgtagccga tgacgttcca gtgggcgtcc
    18121 agcagccagg tggggttggg catctgctgg tcgagcagcg cctgcagcgc tcggcgggta
    18181 ggcgagtcgt accccggcgc cggagtcacg gatccggcac cacccgtgct gtacaggacg
    18241 agggcctgct gctcgtcgcg ccccaggagc agcagttcgc tcaggacgtc gcactggtcg
    18301 cgcttcaggc gcgtgtgcgc gccggattcc aacatgcgat accaacgctc actgcgccca
    18361 caagcctcgc cgagctcccg ctgggtgacc gcccggccca ggcggtggct cgcggcggcg
    18421 cgccacgccc gcagaagtcc cgcgagcccc atgagccgtc caggcagcgg ctcatcctcc
    18481 gcgccgtctc ccccgtttcc cgggaatcgc ttagccatcg agatcgtttt gcctttcata
    18541 cgcagttgtc gttccccgag acggcagagg ggcatcctat cggcgcccac cgacaccaaa
    18601 ggcgacttta cgcaatcact ttttgatctt ggcggggtac cttgctcgct caaacgcgaa
    18661 gacatgaccc agatcacaag aataatgagg gggtggaatt tacccctagc gcgtaaaagg
    18721 catcgccatc cgttcgggca cgattcgggc attacgaccg tcaatttttt tgccggtctg
    18781 accggcaaaa aaattgacgg tccttgtttt tctgacgctc gccgccggtg atcgtcaagt
    18841 gataaccggc gttccgcaac gcgtgactac tgctcagctg cacaccagag ccgacgactt
    18901 acccttcagg agtcgccccg gcaactctca cccgtcattc gatctacgcg cgtcgaccag
    18961 cgttttggcc gattgactgg tcacggtaag tgcgacttaa atcgtccgtg ttcgacactt
    19021 tgcagggggg cctctcccga cagcacatgg gaaggagcgg atcgtgcctt cgtcttgctc
    19081 gacagaatcg acagggcgct cattacagcg cgcatccgcc cgtcacctcc cgctctgtga
    19141 cgcacgcctc ccaagacgaa ggcgcactgg cgctcaacga cgcccgtggg gcactcgccg
    19201 ctttgcccac atcactggcc gatacctgtg gctgacgagt agtggagagt tttagagcaa
    19261 actctggatc ttgacggggg cccatgcgta tgttcgtcgt ccctcgccgg aaccccggtg
    19321 agtcaccgct gccgcgaagg acgcaaatgc gcaggagccc accctgtcga gtgacgtagc
    19381 tccaatacag cgacggcgcc cgagagcggc aactctcgga cgccgatcac tgaacggcta
    19441 acccgcctaa aagcggatcg tgcccatcat caccacgctg aacccttcgc acgggacacc
    19501 tcagcgtggc aacaccaagg agattcttgc atgtcttgtc ccctgcccga aaggctcgga
    19561 gacacgatct acgcggcagc gcccctccgc tgtcgtgagc ctgcgggggc acgctcggta
    19621 gccctcgtgg acgggagtgg ccgatgagtg tcgatgcccg cgagtggggg tgggaacaca
    19681 gctccagcaa gggggtagcg cgcctggtcc tgctgtcgat cgccgaccgc gtgccggacg
    19741 agaagtgcgt cgcctgggct tccctggcca gcctggtcac gcgcaccaac gcctcgcgca
    19801 ccgcagtgcg gaccgcactc gcagcgctcg ccgagagcgg cgagttggaa ctgctcgact
    19861 atctggacgg tccgcagcgc gcctcggtct accgcctgcc gcatgccgcc gcctggctgg
    19921 ccaaggtcgc aaaggccaca aaagacgacc ccgacgcgta cgtcgagcca cccacggact
    19981 cggacccgat acccgagctg gatgaggagg ccgagaccca gctgcggcgg tacgggatct
    20041 ggcccaagaa gaggaaggat tccgacccgt cgcggcgaaa tccgaccggt gcggaatctg
    20101 acccccctcg acggaatccg ccccctcgac gtgccggaat ccgtaccgcc ggcggtacgg
    20161 attccgcacc ccagaaccgt agtgaaccga aggtgaaccg gaatagcagc agtagtggtg
    20221 ctgccaccat cccggtcgac cagtggcaga tcgacactgc cactcaggca tgggcccatc
    20281 agcacggaca cctcgaccgg ctcagcgagg agggcctgct ggcctccgac gcgaagtggc
    20341 gcgtccatcg cgcgaactgg caaccgcgga aggccgccgc ctgggctgcc gactggcgct
    20401 cctggatcgc ccgcgagcac agtcccgctc ctggccgtcc gaacctctac gccgtgccag
    20461 gcaacggcgg cacctcgggc gcaggcggga tgacccgcgc cgaggcccac actgcagccc
    20521 ttctcgccgc cctggacgag tcgaccgaga acggagcagc agcccagtga ctccacatga
    20581 aatcggcgcc ctgctggcct acatcggccg cctcgacccc cgactctccc ggaccgacac
    20641 gggcgaagcc cgcgaccaga tcgcccagtg gcacgagttg ctcggtgacg tgccgccggc
    20701 caccgcccac gggtgggacg cccgcgtcac cgctcgcgag cacatcctcg actcgccgta
    20761 tccgatcatg cccgtggaca tcgctcgcaa gtggcgggcg taccggcgcg accgccttca
    20821 gcggcacacc gatcccctgc cgtccgccag cccggacgac caggctgcct ggaccgccga
    20881 actacgcgga acccggctcg ccgtggccac aggtgtcgca gcgcccactc ggcaccgtga
    20941 actcaccggc agtgagttcg agcctgaacg ccaggggcag ctgcgggaga tcggctcctg
    21001 catccctccc catgtccgag aggctctgtc gccgtatcgg cctgcccgcg cggcacggga
    21061 agcagccatc gcccagggcc aacccgacgt gctaggggtc cggtgcgagc actgccacgc
    21121 cgaggtcaac gaaccgtgcc gcagcaggcg cctcggcctc gacggacagc cccgggccaa
    21181 cgccccacgc tccacccctc accccagccg tgtcgacctc gccgccaccc agcaggtgca
    21241 gcagcccgtg atggcctgac cggctctctt cccctcgcgc acccgccccg cccggtgtgc
    21301 cccatccact ccccggttac ggcacacccc gcgccgaagc cagcgccgac gccgcgtccc
    21361 gcctcgaccg cccggtgcgc caacgcggct gccacggaga caccttgcgc cacatcacat
    21421 cccacatcgc cccagccacc ggcctgcgcg gcatcgccga caccagctgg cacccgcacg
    21481 gtgcgtgcca cggcatggcc cccgaggacg ccgacgccac cttcttcccc ctgccccgag
    21541 accacgacgc catcgaagag gccaaggagt tgtgctctat gtgcccagtc cgccaggact
    21601 gcctcaacta cgccctggag aaccggctca aggacggcat ctggggtggg ctgaccgagg
    21661 ccgagcgccg cccatggcac gacggactgc cccaacgcct cgactaccgg cgggtgatcg
    21721 cgttcttcaa cggacgcgat gtgcacctga ccgaggccga gcgccagatc atcgtcgacc
    21781 acgcctacgt ccgaggatgg cgcccctacc gcctcgccgc cgccctcaag atcagcaaca
    21841 agcacgcccg ggacctgctc aaggacgccg ccaacaaggt cttcgaccgc gacctcaagc
    21901 tcggcgtgcc cccgcggccc aagcagaaga agccgcagga gaagaagacg gcccagacgc
    21961 agaacacgag ccacctccgg tccggcgcgc cggccaaggc gcagccagtg cagtcgactt
    22021 ccgctcgcgc ccctcacgga aaggccgcat gacccacctc tccctgctcg tcgattcgcc
    22081 cccggacctg tccgccctcc tcgccgtcgg tgccccgctc acggccatcg ccctcgccct
    22141 gacgagctgg gcgatccgcc gcaagggaac agccgtgaag aaacgtctcg gcgaccccgc
    22201 ggtcgtggtg gccgcgctcg ccgccgtcgg ctgcaccgcc tacagcgcgg acaccagctg
    22261 gcgcttcgcc gccgactacc tcgacatcgc cggcactctc gagcgcgtca tgctgttcag
    22321 cgccgcggaa ctcgggctct tcgccaccgc gttggtggcc cgcaagaacc tggccaccca
    22381 aggagcaccg gggctgccag gcacgctggt ctgggtgatc accagtgtgc agatcatccc
    22441 cgcctatgcc gagagcggcc ccgtcggcgg tacagtccgt gccttcgtcg gcccgatcat
    22501 ggcggcgttg ctgtggcacc aggccatggg gatcgagctg cgtctgcgca ctcccggcgc
    22561 cgcctccacc gggctgatcg cgaccctggg gcgcgaggcg cgccagcggc tgctctcccg
    22621 cctcggcatc gccgcccaag cacgcgacgc ggcgcaaatc acgcgcgacc gagccaccgt
    22681 gcgagcggcg gaactcgcca cccgtctcgc caaccgtgct cccgccaagc ggaccaaccg
    22741 gcacggacgt cgactcacac gacggctgga gaaggcgatc ggccgagcag aggtgggcac
    22801 cgatcctcaa cagcgcggtg agctgctggg ccaactcgcg gcacggcggc acgcgcccgc
    22861 gctcgccacg atccccttgc gtcccccgtg gggaatcacc ccgcaaagtg aaggcgccgc
    22921 gtcgctcccg ccacagcatg agcacagcac ggtggtcccc aacaacggtc cccgtgacga
    22981 ggcgcagccg cttgcggagc ggggaccgtg cagcaggcgg ggaccggtcc cctcaaactg
    23041 cggcattgcc gtggaggcag atagcgggac cggcgaccgt ggcgcgggga ccgagccgga
    23101 ggccgggaac cggggaccga gcgcctccac caccgggacc gaacccaccg gggaccgggg
    23161 accaaccacc cccaccaccg ggaccgaacc caccggggac cggggacacg cggtccctct
    23221 gcggcggaag ccgactacga agcccaagag caggagcaat cgcggcagcc ggtcccgcgg
    23281 tccgcaacgg caacggccag cagacgcgcc agagcagtcg gtggagcagc tcgtgcagca
    23341 agtccgcccg tacgtcccgg ccctgctcga acgggacggc aacgtcgccg tcaccagggt
    23401 tcagctgcgg gagatcctcc ggcgcgaggg cctcaagggc gccaggaacg accgactggc
    23461 cctcgtcctg cagcagctgc ggagcgagga cagcagtgcc aaggcaagga gcaccaggtg
    23521 aagacctgca cccagttcgc aaccatccgc caggagtacg agcgggagat ccgcttcctg
    23581 agcgcccact ccgagcggca tgccggacga ccggcggcga aatcctccgc gaagcacgcc
    23641 gcatggacga aaacgcgcat ggcacgagcc ctcagcagcc acgtcaaccg ctgcctcgaa
    23701 tgcggctaac cctcgcaaag ccgcaggtag acgccctcat cacgtaatcg gtggtccggc
    23761 ccaagccgga ccacccctct tccatacagg acatcaccat gcagcacgca gccatacccc
    23821 accagttcga cgaccatctg atctgggcct tcctgcacac ctttctccgg cacgggctga
    23881 tccgctccac tgtggacggg ccccacgggc agtggttcgt ccagatcatg gccggcgggc
    23941 cgatccacca cctgaccgac accgaggatt cctgcgactt cgtcctcgac atcctgcaca
    24001 tcatcgacga cgtcacggcc ggtgaacagt gacgaacccg attgaaagct ccgcccccac
    24061 gccgggtgag ccgaaatcca actcggtctc gacgcgagca agttatccgc caagctactc
    24121 ttccccgttg gggaaggcag ctcggccatc tcccgccccg ggggtggcgg gagcggacca
    24181 gcaccggggg gcgcaggtcc ggcaggcggc gaccgagggc ggatcgcagc caggggggac
    24241 caatacgccg tcttcagtgc gcgctgcgcc tgcgacgcgc aagcgttccc cactcacgcg
    24301 cgaacgcaag cgctcccgca tgtgcaacgt ccgactgagc gagaacgaat ggcagcgcct
    24361 ccacgccgca gcgcacatca cgcacacgag tcttcctgcc tacctcgtgc ggtcgggact
    24421 ggctgccgcc gaggacgcac agaacacagc tgctgcggtg gccagtcggc gggagctggt
    24481 taccgagctg ttcaccgccc gtcgtcacct cggtcaggtc ggtaggaacc tcaatcaggt
    24541 cgccaaggca ctgaactccg gggcctggcc gccggaactc gacgtggtcc tcgccgccac
    24601 caaccgcgcc gtactgcgcg tccaggacgt cgccgaccaa ctactcgccc agaaccagga
    24661 ctaggaccag tcaccggcat gatccccagg atccacaagc gcgggaaacg aaccctcggc
    24721 ctgctctact acctctacgg gccaggcacc cacgaagaac acgttgaccc gcgcctcgtg
    24781 gcctcctggg atcaccaggc tcccgatccc ggccgccacc ccggcgccac gtacaaggac
    24841 ctccagcggt tgctggacca gccgctggac aacatcgatc ccgctgaccg gccggcgagg
    24901 catgtgtggc acctgtcggt gcgcaacgcc ttcgaggacc gcatcctgac cgacgaagag
    24961 tggggtgaca tcgcccgtcg tatggtcgcc gccgccggca tcgacgaccc cgacgagggc
    25021 gcgggctgcc ggtgggctgc cgtacgccac gcagatgacc acatccacat cgtcgccacc
    25081 ctcgtacgcg aggacggcta caagcccaac ctcaaccacg atgccgcccg cgtccaggcc
    25141 caagctcgcg ttctcgaagc ggaactgggc ctacggcgtc tgaacaaggg tgatggcacc
    25201 gcggcgcag
//
