LOCUS       NZ_CP119144            25151 bp    DNA     linear   CON 22-NOV-2023
DEFINITION  Streptomyces noursei strain C27 chromosome, complete genome.
ACCESSION   NZ_CP119144
VERSION     NZ_CP119144.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces noursei
  ORGANISM  Streptomyces noursei
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 9627936)
  AUTHORS   Go,B. and Lu,Y.
  TITLE     Control effect and mechanism of Streptomyces NK27 against gray mold
            of grape
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 9627936)
  AUTHORS   Go,B. and Lu,Y.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-FEB-2023) State Key Laboratory for Biology of Plant
            Diseases and Insect Pests, Institute of Plant Protection, Chinese
            Academy of Agricultural Sciences, Yuanmingyuan, Beijing 100193,
            China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 01-OCT-2021
            Assembly Method                   :: ABySS v. 2.3
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 98x
            Sequencing Technology             :: Complete Genomics
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 11/22/2023 14:00:30
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,442
            CDSs (total)                      :: 8,348
            Genes (coding)                    :: 8,203
            CDSs (with protein)               :: 8,203
            Genes (RNA)                       :: 94
            rRNAs                             :: 7, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 145
            CDSs (without protein)            :: 145
            Pseudo Genes (ambiguous residues) :: 0 of 145
            Pseudo Genes (frameshifted)       :: 46 of 145
            Pseudo Genes (incomplete)         :: 121 of 145
            Pseudo Genes (internal stop)      :: 12 of 145
            Pseudo Genes (multiple problems)  :: 30 of 145
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 16:17:19
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 202060
            Orig. end                         :: 227211
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP119144.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..25151
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="aureonuclemycin"
                     /region_number="4"
                     /rules="(her4 and her5 and her6 and her7)"
                     /tool="antismash"
     cand_cluster    1..25151
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(her4 and her5 and her6 and her7)"
                     /kind="single"
                     /product="aureonuclemycin"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..25151
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[10000:15151](+)"
                     /cutoff="10000"
                     /detection_rule="(her4 and her5 and her6 and her7)"
                     /neighbourhood="10000"
                     /product="aureonuclemycin"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..15151
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(her4 and her5 and her6 and her7)"
                     /neighbourhood="10000"
                     /product="aureonuclemycin"
                     /protocluster_number="1"
     misc_feature    complement(74..88)
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 17.73"
                     /tool="antismash"
     misc_feature    182..195
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 18.76"
                     /tool="antismash"
     misc_feature    1172..1186
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 16.4"
                     /tool="antismash"
     gene            1315..2676
                     /locus_tag="P0D74_RS00865"
     CDS             1315..2676
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (extras)
                     Sulfotransfer_4: Sulfotransferase domain"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF036807.3"
                     /locus_tag="P0D74_RS00865"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="sulfotransferase"
                     /protein_id="WP_275460834.1"
                     /transl_table=11
                     /translation="MHLVLRTVGERTTDLALDLAIQHIRPHRVHVVDDVRPFWRAVDLM
                     LGIDHGGASHVVFLDADCLVLEDLRPFLDANELAFVECYVHDPFRGRVPCGVHIIRTDV
                     VERMRRTELRRDDVAWMLRPESTRLELALRGVQDSVQYRGAHILHDHFQHYDHVFAKIA
                     LRELRSRTDASRPVFATAIAQWGQGPDYDVARAAVHHARAHVAEGAPGPDVQRYIEGLP
                     ETALREVAARKLPDRPALTRSEVLRTGQRVRELAGSRADRAKVFGLGLPRTGTRSLRAA
                     LHLLGYDVAHYPVDRASLDALTRGDGRLPLLEHYDGLADVAAVPCFRELDALHRGAKFI
                     LTVRDKASWLASMEANWPEDAAPGSPCGRDHTAHSAARATRRFVREAVYGCRAFDARHL
                     SRVYDEHVATVRAHFDGRPGDLLVLDVVGGEGWERLAPFLSASAPARPFPAERG"
     gene            2706..3695
                     /locus_tag="P0D74_RS00870"
     CDS             2706..3695
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: NAD_binding_4 (14-235). E-value:
                     1.2e-12. Score: 39.4. Matches aSDomain:
                     nrpspksdomains_P0D74_RS00870_NAD_binding_4.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RmlD_sub_bind"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010: NAD-dependent epimerase/dehydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014136351.1"
                     /locus_tag="P0D74_RS00870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="NAD-dependent epimerase/dehydratase family
                     protein"
                     /protein_id="WP_275460835.1"
                     /sec_met_domain="Polysacc_synt_2 (E-value: 1.1e-09,
                     bitscore: 36.8, seeds: 77, tool: rule-based-clusters)"
                     /sec_met_domain="RmlD_sub_bind (E-value: 1.1e-11, bitscore:
                     43.3, seeds: 37, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDCASRRAVPGCALVTGVAGFIGSHLSDALLRQGTRVIGLDRQQP
                     DGGSAAENLRTSLGHPAFDYVRADLRYDDLAPAVAGTDVVFHLAGQPGVRPSWGDAFAD
                     YLTCNVLGTHRLMTECDRQRVPRLVLASSSSVYGQVPEGDSCREDAPARPVSPYGVTKL
                     AAEQLCLAFAQRPAVATSVLALRYFTVYGPRQRADMLIGRALRAALSGVPLPVFGDGSV
                     RRDFTYVDDVVSATLAAAAAPARAEVVNVGGGRSASVTELLEIVGRAVGTAVPTSTSSA
                     QPGDMRATLADPRKAGELLAWKPRVDLTTGVAHQLEWTRQATTFVRRG"
     aSDomain        2748..3410
                     /aSDomain="NAD_binding_4"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_P0D74_RS00870_NAD_binding_4.1"
                     /evalue="1.20E-12"
                     /label="P0D74_RS00870_NAD_binding_4.1"
                     /locus_tag="P0D74_RS00870"
                     /protein_end="235"
                     /protein_start="14"
                     /score="39.4"
                     /tool="antismash"
                     /translation="VTGVAGFIGSHLSDALLRQGTRVIGLDRQQPDGGSAAENLRTSLG
                     HPAFDYVRADLRYDDLAPAVAGTDVVFHLAGQPGVRPSWGDAFADYLTCNVLGTHRLMT
                     ECDRQRVPRLVLASSSSVYGQVPEGDSCREDAPARPVSPYGVTKLAAEQLCLAFAQRPA
                     VATSVLALRYFTVYGPRQRADMLIGRALRAALSGVPLPVFGDGSVRRDFTYVDDVVSA"
     gene            3892..4893
                     /locus_tag="P0D74_RS00875"
     CDS             3892..4893
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: TauD (12-294). E-value: 2.2e-56. Score:
                     183.5. Matches aSDomain:
                     nrpspksdomains_P0D74_RS00875_TauD.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TauD"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1121: dioxygenase, TauD/TfdA"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018385920.1"
                     /locus_tag="P0D74_RS00875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="TauD/TfdA family dioxygenase"
                     /protein_id="WP_275460836.1"
                     /sec_met_domain="TauD (E-value: 3e-54, bitscore: 183.5,
                     seeds: 119, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIEEYSRIDVRCIAGKIGANIRGVDLRELGEHEADTIREIRTALL
                     RHKVVFFGEQHLNHADHVAFARLFGEVTRLPGPKHGTHPEGFPEILIVDRQAAGDRRGL
                     RFEERLYRKSDRHDSGWHVDIASSVNPPALSFLRCEVAAEHGGDTQWTNLAAAYEGLSR
                     PLQQLADSLRAEHALHAGVQLLLSDDEDLAVIRKRVEDTLISLHPVVRVHPETGQKALF
                     LPPASVSHLTELLPWESRGILDVLFSHISRPEYTVRHRWEPGDVAVWDNRAVAHLQPTD
                     LHHTEYERRMYRVLVLGDRPVGPDGFRSESVRGAPLQPFTGPGDTSAGTVSA"
     aSDomain        3928..4773
                     /aSDomain="TauD"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_P0D74_RS00875_TauD.1"
                     /evalue="2.20E-56"
                     /label="P0D74_RS00875_TauD.1"
                     /locus_tag="P0D74_RS00875"
                     /protein_end="294"
                     /protein_start="12"
                     /score="183.5"
                     /tool="antismash"
                     /translation="IAGKIGANIRGVDLRELGEHEADTIREIRTALLRHKVVFFGEQHL
                     NHADHVAFARLFGEVTRLPGPKHGTHPEGFPEILIVDRQAAGDRRGLRFEERLYRKSDR
                     HDSGWHVDIASSVNPPALSFLRCEVAAEHGGDTQWTNLAAAYEGLSRPLQQLADSLRAE
                     HALHAGVQLLLSDDEDLAVIRKRVEDTLISLHPVVRVHPETGQKALFLPPASVSHLTEL
                     LPWESRGILDVLFSHISRPEYTVRHRWEPGDVAVWDNRAVAHLQPTDLHHTEYERRMYR
                     V"
     gene            4922..5443
                     /locus_tag="P0D74_RS00880"
     CDS             4922..5443
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024273.3"
                     /locus_tag="P0D74_RS00880"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DinB family protein"
                     /protein_id="WP_275460837.1"
                     /transl_table=11
                     /translation="MTPCRECGFEYDLSLAPAVSELIRGYTSEYEDLLRTEPTALRRRS
                     APQVWSALEYACHVRDVLLIQRERALTARHRERPVAEPMGRDERVDHDGYAEQQPADVA
                     RQLRDAAWLFANVLDRLSPAAWDRTLVYTYPERAERSLRWLAVHTLHELRHHLHDMRGQ
                     LPSCVVPLTD"
     gene            complement(5680..6438)
                     /locus_tag="P0D74_RS00885"
     CDS             complement(5680..6438)
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1199: NmrA family
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016574783.1"
                     /locus_tag="P0D74_RS00885"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="NAD(P)H-binding protein"
                     /protein_id="WP_275460838.1"
                     /transl_table=11
                     /translation="MTRNPAGASLPAQVVWGDFDDRDSLDSALAGVDALFLLDAPGAWI
                     ERHDLAMLDAVRSHGVRKVVKLSAIGTGENPALRVGGWHLPGERALRAGTAAWTILRPS
                     SFATNTPHWASTIRAGQPISNLTGNGAQGVIDPRDIAEVAVAALTTPDHAGRTYTLTGP
                     ELLSTPDQAEILRKVLGRQIGIVDVPLDVARRQMIAAGRTPEFAHGAMHGQRHIAEGGN
                     ARLTDDVHAVLGHAARTYARWAHDHRAAFD"
     gene            <6511..6873
                     /locus_tag="P0D74_RS00890"
                     /pseudo=""
     CDS             <6511..6873
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1097: transposase"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020131513.1"
                     /locus_tag="P0D74_RS00890"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="RVRVARPEDGRPRTRPDRVLGDKAYGSHANRAYLRRRGSRCTVPE
                     GTDQVRDRKNRGSAGGRPPACGKSVYWRRHSVECGVNRLKRHRAVAARYHPARPRRHAI
                     RIKIITCLARSCGMST"
     misc_feature    6909..6927
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 17.99"
                     /tool="antismash"
     gene            6985..9738
                     /locus_tag="P0D74_RS00895"
     CDS             6985..9738
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1149: LuxR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF024589.3"
                     /locus_tag="P0D74_RS00895"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="LuxR family transcriptional regulator"
                     /protein_id="WP_275460839.1"
                     /transl_table=11
                     /translation="MGSVLLEREEALAAAVRAGESARSGAGRWLVFGAAAGTGRTTVLR
                     EVAGREAAGGAMRVLRADCSPEESGFPFALVRQLFPEDGEVPFADLPAAEEQMVFHRLV
                     TRLARTADRRPVLLAVDDLHDADMASRRWLGYLARRLADLPVLLVLTECREKGTAVLPS
                     ATGTSVVLRPLGPEAVARLVSARGHGSDWAELCIRACAGNPVLVHALLADLREGPLPRS
                     LSELGGSRYRDAIVHWIRARATPWSRRLALALAVAGGGAALLGGALLHEAAGLRPDHRA
                     ASAGASALRRLFSHPLAREAALAAVDPAELCALRGRIARLLDERGAPTADVAAQLLHLD
                     RPGEEWMTQSLEDAAEDAVRGGRVDEATAFLRHALTAPLTPGRRAGLTLRLGALELPRS
                     ADAGIRRLRAALELHADRHERAAVAPALGAALVARGRTDTAMRVMSQVGSAVDDGELVR
                     VLQTTAAVMASHDAVAWRNAVARMRELAATAPAAVEPLACGLVTEYEVGNGRLSAAEAL
                     GRVLPRLAAPVDPRLRDGWLGTAATLLQWADRLDEARALAEEALPAPPALPDLTDIGRQ
                     CLISVRAEAALWAGDFRRVIAENAPLLDACAGQGIRMPHLASMVALAHCELGHRAHAQR
                     LLAGLDEESADSSWEWNELHYARASLHMAEGNWQAALDDYLSCGRGQSARDFVSPVATP
                     WRSGAALALVGLGQPARALDLAEEELRHARTWGTPRTVSRALRAHAAAVGGRRGLESLS
                     EAAAVLRTAPAPVELVETLLDLGHARIHVGNSRKGREDLHEAHALALRLLAPDPTEHPD
                     APATGRLLRATGKALRASGARGTRRHATGSAALTRAERRIVELAAQGQTNAQIGEVLHL
                     ARRTVETHLTNAYRKLGVTRRTQLASRLTGTGTAVSSSARSLTTSG"
     misc_feature    7567..7569
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            10001..11596
                     /locus_tag="P0D74_RS00900"
     CDS             10001..11596
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     aureonuclemycin: her4"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004941311.1"
                     /locus_tag="P0D74_RS00900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_275460840.1"
                     /sec_met_domain="her4 (E-value: 4.2e-285, bitscore: 945.5,
                     seeds: 189, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLEGPLGVGDLLAAVRAVLDGHGGAPARPELTVHGPGQYTVRVGG
                     DRLDIRSRPLSDQPPGTLDPVLDGPGVRRIVLTASDTPSERARDLFTALTEAIGRRARC
                     YTEAEAAAIAAGMPLTGRYAQPEPALAGWALIFRDHYVENSVGFLLAMERAGLDPEWIF
                     ALSKGDRTQHRERVHSWFLRRGYASDTLDNSVINGTAGAAEAARARAVDAQVANFVRRA
                     HVAGRKVLVIDDGGLLAQGYGSDGPGPRVDAAIELTVSGLKRITAAPGELAIPVLNMAR
                     SQLKSRLGYNEIADSCVRRLRAIVPGQKFIGRHVLLLGYGTLGARAARSLRALGCRVAV
                     VDTDILALITAAEDGFETHRSIAEALDRQRPFLILGSSGGTAVTAEDVPLLPDGVLLAG
                     FATKDFSVLTDGYPGATAQRIPHVGVRYDLPHATTATVLGDGRSLNLFEYEGIANRGYD
                     AYRAGTLLAALALCRDPERFPPGLHLEPVDSIIDNAGLFDAYYTQYLCARSAPLGTGAF
                     SGTAETSGEDAHAR"
     gene            11586..12707
                     /locus_tag="P0D74_RS00905"
     CDS             11586..12707
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     aureonuclemycin: her5"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004941309.1"
                     /locus_tag="P0D74_RS00905"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_275460841.1"
                     /sec_met_domain="her5 (E-value: 4.8e-183, bitscore: 607.2,
                     seeds: 189, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPGRPHVCVVGHGVAGRLHHQLLDGMGMSVSVVDPTAPGCGAPFP
                     TAATVGELSTDRPVDVWSVCTPTAGHVQAVAAVLARDPEARILLEKPACRSWEGPELTA
                     LLGAYDRARLVVMNQYAHAKAPAMLEAVRAEFAPRHPVAAIRIAFCKDRREDIAAGRFV
                     DLDYGVFGYEWLHMLAVLGGFLPARAFHHYLLAGPEPQAVRIARDPHLVSTAAHDTTTL
                     SAGAGPAREVEVELYSTIVGPDAPHAAPAPTWARRTAPAADSRLRLARIEAGPVLLTLE
                     LDPVFLPNGTRLPRNTHRLTMDGPHGHREWLIPDSPMDNALRHGIAALLGPGPRPALDL
                     RPLDRIGRLAELARTERPAPSGPLTPAALPTRL"
     gene            12721..14028
                     /locus_tag="P0D74_RS00910"
     CDS             12721..14028
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_function="GO:0051536 - iron-sulfur cluster binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     aureonuclemycin: her6"
                     /gene_functions="other (smcogs) SMCOG1277: Radical SAM
                     domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004941308.1"
                     /locus_tag="P0D74_RS00910"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="radical SAM protein"
                     /protein_id="WP_275460842.1"
                     /sec_met_domain="her6 (E-value: 3.9e-254, bitscore: 842.0,
                     seeds: 189, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSRICLVIPSNKFDQYFIQLPLDAVTAAGHLRAEGHTVTVWDQRL
                     QEAPDGEEFDLLVVFSAIADRAQCYPLELDSVRAAVERAASRYPTARTVAVGPHGTHLP
                     ASTRDELGVDHIACGETDSATVGAVRALLAGADAPVLPGATTPHNLLDSPEPRPRPFPN
                     LPLEELAFPAYDLVPTADYTAEVISGGLPLPGPCGMVLAARGCTYGCTFCHLPFGTKMR
                     NQPLDRVVREIEAQQAAGLEFVFFLDYVFGINRAFYSELCARLEGRGVGWVGQTRAEVV
                     LKNDVTAWARAGCQGMWLGAESPAIADTGVHKRVSEAQIEEAVLKLRDAGITPFAFVLL
                     GLPQDQACISGRLVDWAAKLPAWFGINQLYLRPGTTLYDQLAPRYNGGVLPATWREVQE
                     VTRRYRAAYPTDLDHQQRRLTELPNYLGNTIAPVAG"
     gene            14039..15151
                     /locus_tag="P0D74_RS00915"
     CDS             14039..15151
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0016651 - oxidoreductase activity, acting
                     on NAD(P)H [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     aureonuclemycin: her7"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GFO_IDH_MocA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GFO_IDH_MocA_C3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1079: oxidoreductase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016576688.1"
                     /locus_tag="P0D74_RS00915"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="Gfo/Idh/MocA family oxidoreductase"
                     /protein_id="WP_275460843.1"
                     /sec_met_domain="her7 (E-value: 1e-208, bitscore: 691.8,
                     seeds: 189, tool: rule-based-clusters)"
                     /sec_met_domain="GFO_IDH_MocA (E-value: 2e-23, bitscore:
                     82.2, seeds: 39, tool: rule-based-clusters)"
                     /sec_met_domain="GFO_IDH_MocA_C3 (E-value: 7.2e-29,
                     bitscore: 99.2, seeds: 4226, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLRFGILGCGSIGGFLGRLLARPDGPLRERARLVAVAGRDPVRAH
                     RLASELGCEALAVPELLARTDIDAVAVCTPSGTHAELGTAALRAGKHVLVEKPVDVTPE
                     AADRLIAAARHTGRTLGVISQHRFDPAAEVAKAAIEDGTLGRITSVLIEVPLWRARSYY
                     ASGQWRGTRALDGGGALMNQAVHAVDLAQWLAGPVVEAAAHTGLLAHDGIEVEDVATAS
                     LKFADGALGALLATTAAYPGRTTRVAVNGERGSVVIDNDELAYFHTAREGERTTPYGAY
                     GDGNQAADRCPPPREPPPRDRIGLLHQPHRDQLADFCDAVRTGRPPLVDGAAGRRAVAV
                     VHAVYTSARTGRTVRLDESSNLTQDKGRTP"
     gene            15148..16008
                     /locus_tag="P0D74_RS00920"
     CDS             15148..16008
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PCMT"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016576689.1"
                     /locus_tag="P0D74_RS00920"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_275460844.1"
                     /sec_met_domain="PCMT (E-value: 6.7e-09, bitscore: 34.7,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSGTLRHPAPDEHKQALARLFDRSAPTYEKVGVSHFGALGRQLVE
                     EARVREGERVLDVGCGTGAVLVPAARAVGPSGSVTGIDLSAGMVERSRAAIADEGLGNA
                     RALVADAETAHWQPGPPVDGTFDAVLAGISMFFFPHPRAAAARYHRLLADGGRFAISWW
                     GRQDERWNPVFAASAPYGGGSSHRLPPDSPFRSVEDLHAMLSEEGFSSVDTVERTCVTR
                     FRGPHQWWQWVWSTAGRQFWESVPEDAMADAVKAVDAELAELRAPDGSLTSRNIVRFTV
                     AEVAR"
     gene            16005..17627
                     /locus_tag="P0D74_RS00925"
     CDS             16005..17627
                     /EC_number="3.1.1.103"
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1053: beta-lactamase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004941300.1"
                     /locus_tag="P0D74_RS00925"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="serine hydrolase domain-containing protein"
                     /protein_id="WP_275460845.1"
                     /transl_table=11
                     /translation="MSAACTAPHGSRTAAPAAQPLFSREWLRHAEAAAGQRPDEGEALR
                     LGLRLTNPPVGVAGQILVLTDLATGALWFRAGEWDERPTLVLTLRHEEAAVLLFGDGER
                     RVRLFEHGQLVLEGVFLFIFFLDRLLQQDPSGALARLRGFTADAPQAAGPWPDSAATVT
                     APDAEADAVRAATEALPRTMAALRTELGRTTPGAQLHVSHAPSGTTVSAALGSCRPGVP
                     FTRASLPIWYCCSKTLGAVAIGQLWERGLLDPAAPVARYLPWYDGDGRERVTLYQLLTH
                     TSAVPMGLDPLHGAMAAPVALRREQLRNMTVPAGTPPGARINYGPWWAWFLIAEVVRAV
                     DGREYERYLAEEILAPCGMTDTRVVLTPQEYRAEADRLPLIHITGGGLPAQPTHWYATE
                     SSCTRPIPGLNIRGPMSDLALFFAALADGGRGRHGRILLPQTVMALTAHHRVGLVDPFG
                     NADWGLGFRVESRHLGDECTAFSRHASPRTFGHYGLWTSAAFADPDAGLVVALHLNGKT
                     WQEEHQERMITIGDAVYQDLRLT"
     gene            17686..18786
                     /locus_tag="P0D74_RS00930"
     CDS             17686..18786
                     /GO_function="GO:0008171 - O-methyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1042: O-methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016579249.1"
                     /locus_tag="P0D74_RS00930"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="methyltransferase"
                     /protein_id="WP_275460846.1"
                     /transl_table=11
                     /translation="MTTPQSEDAFPADSPHAIIDVAVAFWKSKALLSAVELGVFEELAV
                     RPATRAELTGRLEIAGRGAADFLDALVSLGLLERDGGVYRNSPVADRYLDPRKPATDIS
                     GYLSFLNAGFGCWAGLTDALRSGGRLDFSAALAASRSADQGGAGDPKLVGADATDDTFG
                     EAYAAPDQVTGFLRAMTGYSMGANQAIAERYDWSRSRTVADVGCAEGSLLAQVLSRNPH
                     LQGIGFDLPVVGPGFDAHLERVGLTDRACFAGGDFFTDPLPTADAIVMGHVLHDWDLDT
                     KKTLIGKAYEALPEDGRLLIYESLIDDDRRERTTGLLISLNVSTVSAGGLGYTGAECGD
                     WMRAAGFRDIAVSHLDGPEYLVVGVK"
     gene            complement(19477..20322)
                     /locus_tag="P0D74_RS00935"
     CDS             complement(19477..20322)
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1097: transposase"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014059392.1"
                     /locus_tag="P0D74_RS00935"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="IS5 family transposase"
                     /protein_id="WP_275460847.1"
                     /transl_table=11
                     /translation="MTTKPPRKPYPSDLSDARWALIEPTLTAWRTERQKTSLNLGGKVT
                     DLREVLNAILYVNRTGIPWRYLPHDLPPHTTVFSYFSAWTADGTIEKLGVHLHRIVRER
                     EGRTAEPTACVIDAQSVKTAPSVPTSTQGTDAGKKIVGRKRSIVTDTLGLLLLVMVTAA
                     SVSDNQAGKQLLTQVAANHPTITKAWADTGYKTQAIEHGAALGIDVEVVPRNTQVKGFS
                     VLPRRWVVERSFGWPMMHRRLARDYETKPQHSESMIRLAMLSNLAKRATGETTTTWHNP
                     "
     misc_feature    complement(19858..19860)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    20316..20332
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 16.96"
                     /tool="antismash"
     gene            20768..22867
                     /locus_tag="P0D74_RS00940"
     CDS             20768..22867
                     /EC_number="2.7.11.1"
                     /GO_function="GO:0004674 - protein serine/threonine kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF012298.3"
                     /locus_tag="P0D74_RS00940"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="serine/threonine-protein kinase"
                     /protein_id="WP_275460848.1"
                     /sec_met_domain="Pkinase (E-value: 1.2e-49, bitscore:
                     168.0, seeds: 54, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTEANGELIGGRYRRIELIGQGGMGRVWRGRDETLGRDVAIKEVI
                     FPQGITAEQRDVLLQRVTREARAAARLNHPGIITVHDVVEHQGAPVIVMEYVTGISLAS
                     SIAQSGGLPVRTVAEIGTKMLQALNRAHASGIVHRDLKPDNVLLMDDRVIITDFGIAHM
                     ADSTTALTHTGTIIGTPAYMSPEQLAGKTPSAATDLWALGATLYSAVEGQPPFSAETFT
                     ALVLAVITEDPRPALRAGGLWPVLAALLTKDPAQRATAAQAQAALEQVERTGAAVPVPI
                     PTQVDSAPSPGPHAAHQLPTQTGTPFAPPLSPGSGGTPASGAPRTLGRRSVLWLGLGGA
                     AAVAGGIGIALKTGDHTPPKPKVKPWDYTDEGPRHDGNPPPFAVADGALYVSTEETIVA
                     LDARTGRKRWKGPSDFSREYRYRNPLVAADGAVYASGQIGTTYGLCALDADGRKKWFCS
                     FADSDHRPVVTDGIVYITAYDHVYAVHADNGRKLWGHPLGDRDSGGLAVADGTVYVSGS
                     KALYALDAASGARKWAFPLDYGARIDQPPVVSGGLVYVLDNVTNLHALHAAEGTRKWWL
                     KYNGQGLRAAGDMLYVTGGDDVGNGIVHALDSSTGKRKWGHEVNSSQLSATQLALAGDL
                     LFVASTEDKDGTVYAVDTGDGSQRWSTRLLEKLGSDMAAAYGFVYASINGRVMALDAAT
                     GAFTI"
     gene            <22851..23153
                     /locus_tag="P0D74_RS00945"
                     /pseudo=""
     CDS             <22851..23153
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007379921.1"
                     /locus_tag="P0D74_RS00945"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="GRSRSEHEHDIDGRHQHAGEQPCGMRPGGPVRGVLLTCAGIPERT
                     HAWQNSFHRLARCFERRVTVIDAFFDLTDAIITVRSLIRRAWTTHGWDTRPRCRL"
     gene            complement(24207..24437)
                     /locus_tag="P0D74_RS00950"
     CDS             complement(24207..24437)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="P0D74_RS00950"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_275460849.1"
                     /transl_table=11
                     /translation="MAKAEYYNGWNEDLADFEAEVKKFLHRGRLNITEKKLSQVPGGPP
                     PGSSPQLRHEHGDMVTSTSSVTRVSSTPSSG"
     gene            <24460..>24978
                     /locus_tag="P0D74_RS00955"
                     /pseudo=""
     CDS             24460..>24978
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0005215 - transporter activity [Evidence
                     IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007491719.1"
                     /locus_tag="P0D74_RS00955"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus and C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /product="HAD-IC family P-type ATPase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MAGRFFETHARRRAGEAIGALMDLGAKDAAVLRGGSEVRVPIEQL
                     AVGDEFVVRPGEKIATDGVVVEGSSAVDESLLTGESLPVEVGPEDAVTGATVNAGGRLV
                     VRATRVGLDTKLAQIARLVEEAQTGKAAVQRLADQISAIFVPIAILLAVETLFGWLVLG
                     YPAAVALTAA"
ORIGIN
        1 gactccgagt ccgtgctggg cgaatgcctt cagggccacc gcgaactcgt cgtgctggca
       61 acgaagttcg ggcatcagaa aatgagtatg ggctacggcc cggcggccgg cgcacgcggt
      121 ggacgggctt acatccgccg cgccgtcgag gcatcccttc gccgtctccg cacggaccat
      181 atcgacctct atcaaatcca tacacccgat ccgcacaccc ccgtcgaaga gaccctcgcc
      241 gccctgaccg agttggtccg cgaaggcaag gtccgctaca tcggaaactc caatttcgcc
      301 gggtggcaga tcgccgaagc cgcgtgcgcc gcccgctccg gagggttcga gccctttgta
      361 tccgcacaga accactggtc actgttcgag cgcggcatcg agaccgaagt cgtcccggct
      421 gcacgccatt tcggcctcgg cgtgctgccg tacttcccac tcgcgaacgg cttgctgacg
      481 ggcaaggtgc ggcgtggcaa gccgattccg gaaggaaccc gcatcgcagg cagcgcgcat
      541 cgggtgacgg aagcccggct tgacgcggtc gaggcgctga ctgcctgggg cgcgaagaac
      601 ggtcacagtc tcctggagat cgccatcggt ggcctcgccg cactcccggg atgcagctca
      661 gtgatcgcgg gcgccacgaa ggcggaacag gtgagggcca acgcagcggc gggcgactgg
      721 attccagccg ccggggagct acaggacatc ttggcccttc tgtgaaaagc ggtatcgatc
      781 cgcaacagga cacactcccc catccccacc gcggacgccg cactcatgag gtcatcaact
      841 ggcttatgta gcacggaagt tgacgaccta acgctacgtt tgaggcccgc cgacctacgt
      901 gtcgttcgga catgggcttg atgtcggtct ccggtcagag gtccacgtga ctcacggcac
      961 tccgcaccga gccgcccagg ccgccaggca actcttcgtc acgccgacgg acccaccttg
     1021 tcccggttct cgacggctca ctccgacggc acagtcaccc accctgacgc gagcgcgcgc
     1081 gaaggtggca ggaaccgatc ggccggaagt cgccgcttgg cagtgagggg ccggggcatg
     1141 cactcccgga gacaccgatc gccgggctgt gaccagagtt ggcgatgcca tgggtgagtc
     1201 gagagcctgg gagttccacc agtgcgttca cacgggcagg gcctggtcag agccagagga
     1261 acgggcgcca tccagcaact gaagggtgta agcccgcccg ccggaggccg gcgcgtgcat
     1321 ctcgtcctgc gaacggtcgg cgagcgcacc accgacctgg ctctcgatct ggccatccaa
     1381 cacattcgtc cgcaccgggt gcatgtcgtc gacgacgtca gacccttctg gcgtgccgtc
     1441 gacctgatgt tggggatcga ccacgggggc gcgtcgcacg tggtgttcct cgacgccgac
     1501 tgcctcgtcc ttgaggacct ccgtccgttt ctcgacgcca acgagcttgc cttcgtggag
     1561 tgttacgtgc acgacccctt ccgcggtcga gtgccgtgcg gtgtgcacat catccgcacc
     1621 gacgtggtgg agcggatgcg gcggaccgag ctccgcaggg acgacgtcgc gtggatgctg
     1681 cgcccggaga gcacccgtct ggagctggcg ctgcggggcg tccaggactc cgtgcaatac
     1741 cggggcgcgc atatcctcca cgatcacttc cagcactacg accacgtctt cgccaagatc
     1801 gccctccggg aactccggag ccgtacggac gccagccggc ccgtcttcgc caccgccatc
     1861 gcccagtggg gtcagggccc ggactacgac gtcgcccgcg ccgccgtcca ccacgcccgg
     1921 gcgcacgtcg ccgagggcgc ccccggcccc gacgtacagc gctacatcga gggccttccg
     1981 gagacggccc tccgcgaggt cgcagcgagg aagctgccgg accggccggc gctcacgcgc
     2041 agcgaagttc tccggacggg gcaacgcgtc cgcgaactgg ccggcagcag agcggaccgt
     2101 gccaaggtat tcggcctggg gctgccgcgc accggcaccc gcagtctgcg ggctgccctg
     2161 cacctgctcg ggtacgacgt tgcccactac cccgtcgacc gcgcctcgct cgacgccctg
     2221 acccgagggg acgggcgcct tccgctgctg gagcactacg acggcttggc cgacgtggca
     2281 gccgtcccgt gcttccggga actcgacgcg ctgcaccgcg gcgcgaagtt catcctgacc
     2341 gtccgggaca aggcgagttg gctcgcgtcc atggaggcga actggccgga ggacgcagcg
     2401 ccaggctcgc cctgcggccg ggaccacacc gcccacagtg ccgcccgggc gacgcggcgc
     2461 tttgtccgcg aggccgtcta cggttgccgc gcgttcgacg ccaggcacct ctcgcgcgtg
     2521 tacgacgaac acgtcgccac cgtccgcgca cacttcgacg gccgtccagg cgacctcctc
     2581 gtcctggacg tcgtcggagg cgagggctgg gagcggctcg ccccgttcct gagcgcttct
     2641 gcacctgccc gcccgttccc cgccgagcgg gggtgaacgg ccccgtcgtc gccaccggag
     2701 gattcatgga ttgcgcttcg cggcgcgcag tgccaggctg cgccctggtc accggcgtcg
     2761 ccggcttcat cggctcccac ctctccgatg cgctgctccg ccaaggcacc agggtgatag
     2821 ggcttgaccg gcagcaaccc gacggcggaa gcgccgccga gaacctccgg accagcctgg
     2881 gacatcccgc gttcgactac gtccgcgcgg acctgcggta cgacgacctg gcaccggccg
     2941 tcgcgggcac ggacgtcgtg ttccacctcg ccggacaacc cggagtgcga ccgtcctggg
     3001 gtgatgcctt cgccgactac ctcacctgca acgtactggg cacccaccgg ctgatgacgg
     3061 aatgcgacag gcagcgcgtg cccaggctgg tcctggcctc gtcctccagc gtctacgggc
     3121 aggtcccgga gggggacagc tgccgcgagg acgcacccgc tcggcccgtc tcgccctacg
     3181 gagtgaccaa gctcgccgcc gaacagctgt gtctggcctt cgcgcaacgc ccggctgtcg
     3241 ccaccagcgt gctggccttg cggtacttca cggtctacgg gccgcgccag cgcgccgaca
     3301 tgctgatcgg cagggcgctc cgcgcggcgc tgagcggagt tccgttgcct gtcttcggag
     3361 acgggagcgt ccggcgtgac ttcacgtacg tcgacgacgt ggtctcggcg acgctggcgg
     3421 ccgccgcggc cccggcccgg gccgaggtcg tcaacgtggg cggaggccgc agtgcgtccg
     3481 tcaccgagct cctggagatc gtgggacggg ccgtcggaac cgccgtaccg accagcacgt
     3541 cgagcgccca acccggcgac atgcgtgcga cgttggccga tccacggaag gcgggcgagc
     3601 tgctggcctg gaagccccgc gtggacctga ccaccggagt ggcccaccag ctggagtgga
     3661 cccggcaggc gactacgttc gtgcgtcgtg gctaggtgcc ctccactgtg ggcggcacca
     3721 ggcgccctac ggtcggcccc tcgtacggtc ggccccgtgc gcagaccggc ccgcgggagc
     3781 ccggcagagt cccccgcagc cgcaaaaagc tgagccgcgc gccctccagt tgggcctggg
     3841 cgcgctcgaa gcacgacaat cccacgctgg gcatgtcgga ggagaggcgt cgtgatcgag
     3901 gaatattcca ggattgacgt tcgctgcatc gcgggaaaga tcggggcgaa catccgtggg
     3961 gtggatctga gggaactggg cgagcacgag gccgacacca tcagggagat acgcaccgcc
     4021 ctgctccgcc ataaagtggt ctttttcggc gagcagcatc tgaaccacgc cgaccacgtg
     4081 gcgttcgcgc gacttttcgg agaggtaacc cggcttccgg ggccgaaaca tggcacgcac
     4141 ccagaagggt tcccggagat tctcatcgtc gatcggcagg ccgccggtga tcgacggggc
     4201 ctcaggttcg aggagaggct gtatcgcaag tcggatcggc atgactcggg ctggcatgtg
     4261 gacattgcct catccgtgaa tccaccagcc ctttcgttcc tcaggtgtga ggtggccgcg
     4321 gagcatggcg gcgacaccca gtggacgaat ctcgccgccg cttatgaggg actctcccgg
     4381 cccctacagc agttggccga cagcctgcgg gccgagcacg cgctgcacgc aggagtgcag
     4441 ctcctcctct ccgacgacga ggacttggcg gtgatccgca aacgagtcga ggacaccctg
     4501 atctcgctcc acccagtggt gcgagttcac ccggagaccg gccagaaggc actcttccta
     4561 cctccggcat ccgtatccca cctcaccgaa ctgcttcctt gggaaagccg cggcatcctc
     4621 gacgtcctct tctcccacat cagccgtccc gaatacaccg tgcggcaccg ttgggaaccc
     4681 ggggacgtcg ccgtctggga caaccgcgcg gtggcccacc tccagcccac cgacctccac
     4741 cacaccgaat acgagcgcag aatgtaccgg gtactggttc tgggcgaccg gcctgtcgga
     4801 ccggacggtt tccggtccga gtccgtgcga ggcgcaccgc tccaaccctt caccggcccg
     4861 ggggatacga gcgcgggaac cgtgtcggcg taaaaccggg agggcacgtt accgtgctgg
     4921 catgacgcct tgtagggaat gcggcttcga atacgatctc tctctggctc ctgcggtatc
     4981 cgagctcatc aggggatata ccagtgaata cgaggacttg ttgcggaccg agccgaccgc
     5041 gctgcgacgg cgttcggcgc cgcaggtgtg gtcagctctt gagtacgcct gccacgtgcg
     5101 tgatgtgttg ttgatccagc gcgagcgggc actgactgcg cggcaccgcg aaaggcccgt
     5161 cgccgagccc atgggacgcg acgagcgggt cgatcacgac ggatacgctg agcagcagcc
     5221 ggcggacgtc gcccgtcaac tccgggatgc ggcatggctg ttcgccaacg tcctcgaccg
     5281 gctgtcaccc gcggcgtggg accgcacgct ggtgtacacc tatcccgagc gtgcggaacg
     5341 ctcactgcgc tggctcgccg tgcacaccct tcacgaactg cgccaccacc tgcacgacat
     5401 gcgcggccaa ctaccctcat gcgtggtgcc gttgaccgac tgagaccttc gacagtgggg
     5461 ggcgagctgg tgtcatcggc caccggcgcg tcggttcgtc gagtctggcg ccgtcgtgtg
     5521 gccgttccgg ggatcgggct gtgactggcc gggcagccgg tgcagtgact ggggacgacg
     5581 gcccgacact gccgggtctg ttggtcgtcg gttcgtgctc gtccgggtca gaccagccgc
     5641 cgtcggcccc tcaccactgt cggccccggt gtggctcgct cagtcgaacg cggcccggtg
     5701 atcatgggcc cagcgcgcgt aggtgcgggc cgcgtggccg agcacggcgt gcacgtcgtc
     5761 ggtcagtcgg gcgttgcctc cttcggcgat gtgccgctgg ccgtgcatcg cgccatgcgc
     5821 gaactccggg gtccggccgg ctgcgatcat ctgccgcctc gccacgtcca gcggcacgtc
     5881 gacgatgccg atctgacgac cgagcacctt ccgcagaatc tccgcctggt cgggcgtgct
     5941 cagcaactcg ggtccggtca gcgtgtacgt tctgcccgca tggtccggcg tggtcaacgc
     6001 agcgaccgcg acctcggcga tgtcgcgcgg gtcgatcacg ccctgagcgc cgttgccggt
     6061 caggttggag atcggctgcc ccgcgcggat cgtggaggcc cagtgcgggg tgttggtggc
     6121 gaagctgctg ggtcgcagga tcgtccaggc agcggtgccc gcgcgcagtg cccgttcgcc
     6181 ggggaggtgc cagccgccga ccctgagcgc aggattctcg ccggtgccga tggcggagag
     6241 cttcaccacc ttcctcactc cgtgggaccg cacggcgtcg agcatcgcca ggtcgtgccg
     6301 ctcgatccag gcacccggcg cgtccagcag gaagagcgcg tcgaccccgg ccagcgcgct
     6361 gtcgagggag tcgcggtcgt cgaagtcccc ccacacgacc tgcgccggca ggctggcgcc
     6421 ggcagggttg cgggtcatcg ctcggacccg cgtccaagga ggaacgagcc cgcatcgagg
     6481 ggcgcggcgc tcggcccggc gaccctcggg cgcgtccgcg ttgcccggcc ggaggacgga
     6541 cgcccccgca cacggcccga ccgcgtgctc ggcgacaagg cgtacggctc tcacgccaat
     6601 cgcgcctacc tgcgaaggcg cggtagccgc tgcaccgtgc cggaggggac cgaccaggtc
     6661 cgcgaccgca agaaccgcgg ctccgctggt ggccgcccgc cggcttgcgg caagtcggtc
     6721 tactggcgga gacactccgt cgagtgcggt gtcaaccgcc tcaaaaggca ccgtgcggtc
     6781 gccgcgaggt accacccggc ccggccccgg cgccacgcca tccgcatcaa gatcattaca
     6841 tgtctggcca ggtcatgcgg gatgtcgacc tgagacgaac actggcccgg aataggggat
     6901 ttcgctactt tcggcatgca gtattcatct cgggcgccct gcaccgacgg ggcgtcgtgt
     6961 gcaccgaggc ggaggagtgt gggtatgggc agtgtgcttc tcgaacgcga ggaagccctg
     7021 gcggccgcgg tgagggccgg agagtccgcg cggtccggtg cgggccgttg gctggtgttc
     7081 ggtgcggcgg cggggacggg ccgcaccacc gtgttgcggg aggtggcggg gcgggaggcg
     7141 gcgggcgggg cgatgcgtgt gctgcgcgcg gactgttcgc cggaggagtc ggggttcccc
     7201 ttcgctctcg tgcgccagct ctttcccgag gacggggagg tgcccttcgc agacctaccg
     7261 gcggccgagg agcagatggt cttccaccgc cttgtgaccc gcttggcgcg gaccgccgac
     7321 cgtcggcccg tacttctggc cgtcgacgac ctgcacgatg ccgacatggc gtcacgccgt
     7381 tggctcggct atctggcccg tcggctggcg gacctgcccg tgctgttggt cctgaccgag
     7441 tgccgggaga agggcaccgc cgtgctgccc agtgcgacgg gcacgtccgt ggtgctccga
     7501 ccgctgggcc cggaggccgt ggcccgtctg gtgtccgccc gcggacacgg ctccgattgg
     7561 gccgagttat gtatccgggc gtgcgccggc aatccggtgc tggtgcacgc cctcctcgcc
     7621 gacctgcgtg aggggccgct gccacgcagc ctgtccgagc tgggcggaag ccgctaccgt
     7681 gacgcgatcg tccattggat acgggcccgg gcgacccctt ggtcgcgccg cctcgccctg
     7741 gcgctcgccg tggccggggg cggcgcggcg ctgctcggag gggccctgct ccacgaggcc
     7801 gccggcctcc gcccggacca ccgcgccgcg tccgcgggcg cgtcggccct ccgccgcctc
     7861 ttctcgcacc cgctggcacg cgaggccgcc ctcgcggcgg tcgatccggc cgaactgtgc
     7921 gcgctgcgcg gccgtatcgc ccgcctgctc gacgagcgcg gcgcgcccac tgcggacgtc
     7981 gccgcccagc tgctccacct cgaccggccc ggcgaggagt ggatgacgca gtccctggag
     8041 gatgcggccg aggacgccgt acgcggcggc cgggtcgacg aggccaccgc tttcctccgc
     8101 cacgccctca ccgctccgct cacccccggc cgccgcgccg ggctcaccct gcgcctcggc
     8161 gccctggagc tgccgcgcag cgcggatgcc ggcatccgca ggctgcgcgc ggcgctggag
     8221 ctgcacgccg accgtcatga acgcgccgct gtcgcacccg ccctcggcgc tgcgctcgtc
     8281 gcccggggcc gcacggacac cgccatgcgc gtcatgagcc aagtgggcag cgccgtggac
     8341 gacggtgagc tcgtccgtgt gctgcagacc accgccgccg tcatggcctc ccacgacgcg
     8401 gtcgcatggc gcaacgccgt cgcccgcatg cgggaactgg cggcgacggc ccccgccgcc
     8461 gtcgagccgc tcgcctgcgg cctggtcacc gagtacgagg tcgggaacgg ccggctgtcg
     8521 gcggccgagg ccctcggccg tgtgctgccg cggctggccg caccggtgga cccccggctc
     8581 cgcgacggct ggctgggaac cgcggccacc ttgctgcagt gggccgaccg actggacgag
     8641 gcacgcgccc tcgccgaaga ggccctcccc gccccgcccg cgctcccgga tctgacggac
     8701 atcggccgac agtgcctgat cagcgtgcgg gccgaagcgg ccctgtgggc aggtgacttc
     8761 cggcgcgtga tcgccgagaa cgccccgctc ctcgacgcgt gcgccgggca ggggatccgc
     8821 atgccccacc tggcgtccat ggtggcactc gcccactgcg aactcggcca ccgtgcccac
     8881 gcccagcggc tgctggccgg cctcgacgag gagagcgccg acagctcctg ggaatggaac
     8941 gaactgcact acgccagagc ctctctgcac atggccgagg gcaactggca ggccgccctc
     9001 gacgactacc tgtcctgcgg ccgcggtcag agcgcccgcg acttcgtcag ccccgtggcc
     9061 accccctggc gctccggtgc cgccctcgcc ctggtcggac tcggacagcc ggcgagagcc
     9121 ctggacctcg ccgaggagga actgcgccac gcgcggacct gggggacacc ccgcacggtc
     9181 agccgggccc tgcgggccca cgccgcggcc gtgggcggcc gccgggggct tgagtcgctg
     9241 agcgaggccg cggccgtgct gaggaccgca ccggcccccg tcgaactcgt cgagaccctc
     9301 ctcgacctgg gccacgcgcg gatccacgtc gggaacagcc gcaagggccg cgaggacctg
     9361 cacgaggccc acgccctggc actgcgcctg ctggcccccg accccaccga acaccccgac
     9421 gcgcccgcca ccggacgcct gctccgcgcc accggtaagg ccctgcgggc cagcggcgcc
     9481 cgcgggaccc gccggcacgc gacgggcagc gccgcactca cccgggcaga gcggcgcatc
     9541 gtcgagctgg cggcccaggg ccagacgaac gcccagatcg gcgaggtact ccacctggcc
     9601 cgccgcaccg tggagaccca cctcaccaac gcctaccgca aactcggcgt gacccgccgc
     9661 acccagctcg cctcccggct gaccgggacg ggcacggcgg tctcctccag cgcgcggagc
     9721 ctcaccacat ccggctgacc agggccgtcg cccgggccgg gcgaccgccg agatcgtgga
     9781 tctccacgat ggtcgtcaag atcccccgca cggcaggctg acctgagaac accagccgga
     9841 ccaggagcac ctcctgattc cggcccggcc gcaacacgtc cgttctcacg aggaatacac
     9901 gcctggcgtg ggtggatata tgtcggtatc tgatgttgct tcgcgtcgca ccgtccccga
     9961 caggggactg ggggatcccc atccgccggg cccgtgcgaa gtgttggagg ggccgctcgg
    10021 cgtcggtgac ctgctggcgg ccgtgcgcgc ggtcctcgac ggccacggcg gggcgccggc
    10081 gcgaccggag ctgaccgtgc acgggcccgg ccagtacacg gtgcgggtgg gcggcgaccg
    10141 gctggacatc cgcagccggc cgctgtccga ccagccgccc ggcaccctgg accccgtcct
    10201 cgacgggccg ggggtccgcc ggatcgtgct caccgcctcc gacaccccct cggagcgggc
    10261 ccgtgacctg ttcaccgcgc tgaccgaggc gatcggccgg cgggcccggt gctacaccga
    10321 ggccgaggcc gccgccatcg cggccggcat gccgctgacg ggccgatatg cccagcccga
    10381 acccgcgctc gccggatggg cgttgatctt ccgggaccac tatgtggaga acagcgtcgg
    10441 cttcctgctg gccatggagc gcgccggact cgaccccgag tggatcttcg cgctgtccaa
    10501 gggcgaccgg acgcagcacc gcgagcgggt gcactcctgg ttcctgcgcc gcggctacgc
    10561 cagcgacacc ctggacaact ccgtcatcaa cggcacggcc ggagcggcgg aagcggcccg
    10621 cgcacgggcg gtggacgccc aggtggccaa cttcgtccgc cgggcgcacg tcgccggccg
    10681 caaggtcctg gtcatcgacg acggcggcct gctcgcccag ggctacggct ccgacgggcc
    10741 gggaccgcgg gtggacgcgg ccatcgagct gacggtcagc gggctcaagc gcatcacggc
    10801 cgcccccggc gaactggcca tccccgtcct gaacatggcc cgctcccagc tgaagtcacg
    10861 gctgggatac aacgagatcg ccgactcctg cgtgcgccgg ctgcgggcga tcgtgcccgg
    10921 ccagaaattc atcggccggc acgtcctgct gctgggctac ggcaccctgg gcgcacgggc
    10981 ggcccgctcg ctgcgggcgc tgggctgccg ggtcgccgtg gtggacaccg acatcctggc
    11041 gctgatcacc gccgccgagg acggcttcga gacccaccgc agcattgccg aggccctcga
    11101 ccggcagcgg ccgttcctca tcctcggcag cagcggcggc accgccgtca ccgccgagga
    11161 cgtgccgctg ctgcccgacg gcgtgctgct ggccggcttc gccacaaagg acttcagcgt
    11221 gctgaccgac ggctaccccg gtgccaccgc gcagcgcatc ccgcacgtcg gcgtgcgcta
    11281 cgacctgccg cacgccacca ccgccactgt gctgggcgac ggccgctcgc tgaacctctt
    11341 cgagtacgag ggcatcgcca accgcggcta cgacgcctac cgcgccggca ccctgctcgc
    11401 cgcgctcgct ctctgccgcg atccggagcg gttcccgccc ggcctccacc tggagccggt
    11461 ggactcgatc atcgacaacg ccgggctgtt cgacgcgtat tacacccagt acctgtgcgc
    11521 gcggtccgcc ccgctgggca ccggagcgtt ctccggcacc gctgagacct ccggtgagga
    11581 cgcccatgcc cggtaggccg catgtgtgcg tcgtcggcca cggcgtggcc ggccgactgc
    11641 accaccaact gctcgacggc atgggcatgt ccgtgtcggt cgtggacccc accgcgcccg
    11701 gctgcggcgc ccccttcccc accgccgcca ccgtgggaga actgtccacg gaccggccgg
    11761 tggacgtctg gtcggtctgc accccgaccg ccggccacgt acaggccgtg gccgccgtcc
    11821 tcgcccgcga ccccgaggcc cgcatcctgc tggagaagcc ggcctgtcgg tcctgggagg
    11881 gccccgaact caccgcgctg ctcggcgcgt acgaccgggc ccgcctggtg gtgatgaacc
    11941 agtacgcgca cgccaaggct cccgccatgc ttgaggccgt acgcgccgag ttcgcccccc
    12001 gacacccggt ggcggccatc cgcatcgcct tctgcaagga ccgccgcgag gacatcgcgg
    12061 ccggccgctt cgtcgacctc gactacggtg tcttcggcta cgagtggctg cacatgctcg
    12121 ccgtcctcgg cggcttcctg cccgcccggg ccttccacca ctatctgctg gccgggcccg
    12181 agccacaggc cgtacggatc gcccgtgacc cccacctggt cagcaccgcg gcccacgaca
    12241 ccacgacact gagcgcgggt gccggccccg cgcgcgaggt tgaggtcgag ctgtactcca
    12301 ccatcgtcgg ccccgacgcc ccgcacgcgg cccccgcgcc cacctgggcc cggcgcaccg
    12361 cacccgccgc cgacagccgg ctgcggctgg cccggatcga ggccggaccg gtcctcctca
    12421 ccctggaact cgacccggtt ttcctgccca acggcacccg gctgccccgc aacacccacc
    12481 ggctgaccat ggacgggccg cacggccacc gcgagtggct gatccccgac tccccgatgg
    12541 acaacgcgct gcggcacggc atcgcggccc tgctcggccc cggcccgcgc cccgcgctgg
    12601 acctgcggcc cctcgaccgc atcggccggc tggccgaact ggcccgcacc gaacgccccg
    12661 cgccctccgg ccccctgacc cccgccgccc tgccgacccg actgtgagag tgaaccgccc
    12721 atgagccgga tctgcctcgt catccccagc aacaagttcg accagtactt catccagctc
    12781 cccctggacg ccgtcaccgc cgccggccac ctgagggcgg agggccacac cgtcaccgtg
    12841 tgggaccagc ggctccagga ggcgcccgac ggcgaggagt tcgacctgct ggtcgtcttc
    12901 tccgcgatcg ccgaccgtgc ccagtgctac ccgctggagc tggactccgt acgggccgcc
    12961 gtcgagcgcg ccgcgtcccg ctaccccacg gcccgtaccg tcgcggtcgg cccgcacggc
    13021 acccatctgc cggcctccac ccgcgacgag ctgggcgtgg accacatcgc ctgcggcgag
    13081 accgattcgg ccaccgtcgg cgcggtccgc gccctgctgg ccggcgccga cgcccccgtg
    13141 ctcccgggcg ccaccacccc gcacaacctg ctggactcac ccgagccccg cccccgtccc
    13201 ttccccaacc tccccctgga ggaactcgcc ttccccgcct acgacctggt gcccaccgcc
    13261 gactacacgg ccgaggtcat ctccggtggg ctgccgctgc ccggcccctg cggcatggtg
    13321 ctcgccgccc gcggctgcac ctacggctgc accttctgcc atctgccgtt cggcaccaag
    13381 atgcgcaacc agccgctgga ccgggtggtg cgcgagatcg aggcccagca ggccgcgggc
    13441 ctggagttcg tgttcttcct cgactacgtc ttcggcatca accgcgcctt ctacagcgag
    13501 ctgtgcgccc ggctggaggg ccgcggggtg ggctgggtcg gccagacccg cgccgaggtc
    13561 gtcctgaaga acgacgtcac cgcctgggca cgggccggct gccagggcat gtggctgggc
    13621 gccgaatcgc ccgccatcgc cgacaccggc gtccacaagc gggtcagcga ggctcagatc
    13681 gaggaggccg tcctcaagct gcgggacgcc ggcatcaccc cgttcgcctt cgtcctgctg
    13741 gggctgccgc aggaccaggc gtgcatctcc ggccgcctgg tcgactgggc cgcgaagctg
    13801 cccgcctggt tcggcatcaa ccagctctac ctgcggcccg gcaccaccct ctacgaccag
    13861 ctcgcccccc ggtacaacgg cggggtgctg cccgccacct ggcgcgaggt ccaggaggtc
    13921 acccgccgct accgcgccgc ctaccccacc gacctggacc accagcagcg gcggctcacc
    13981 gaactcccca actacctggg caacaccatt gccccggtgg cgggctgagg aggcggccgt
    14041 gctgcgcttc ggcatcctcg gctgcggctc gatcggtggc ttcctcggcc gcttgctggc
    14101 ccggcccgac ggcccgctgc gtgagcgggc ccgtctggtg gcggtcgccg gacgggaccc
    14161 ggtacgggca caccggctcg cctccgaact gggctgcgag gcactcgccg tgcccgagct
    14221 gctggcccgc acggacatcg atgcggtcgc cgtgtgcact ccctccggca cccacgccga
    14281 actgggcacc gcagccctgc gcgcgggcaa gcacgtcctg gtcgaaaagc ccgtcgacgt
    14341 caccccggag gccgccgacc ggctgatcgc cgccgcccgg cacaccggcc gcaccctcgg
    14401 cgtcatctcc cagcaccgct tcgaccccgc cgccgaagtg gccaaggccg ccatcgagga
    14461 cggcaccctg ggccggatca cctccgtcct catcgaggtc cccctgtggc gggcgcggtc
    14521 ctactacgcg tcggggcagt ggcgcggcac ccgcgccctg gacggcggcg gcgccctgat
    14581 gaaccaggcc gtgcacgccg tcgacctcgc ccagtggctg gccggccccg tggtggaggc
    14641 cgccgcccac accggcctgc tcgcccacga cggcatcgag gtcgaggacg tggccaccgc
    14701 cagcctgaag ttcgccgacg gcgcgctcgg cgccctgttg gccaccaccg ccgcctaccc
    14761 ggggcgtacc acccgggtcg cggtcaacgg cgagcgcgga tcggtcgtca tcgacaacga
    14821 cgagctggcc tacttccaca ccgcccgcga gggcgagcgg accaccccct acggcgcgta
    14881 tggcgacggc aaccaggccg ccgaccggtg cccgccgccg cgggagcccc cgcctcgcga
    14941 ccgcatcggc ctgctccacc agccccaccg cgaccagctc gccgacttct gcgacgcggt
    15001 ccgcaccggc cgaccacccc tggtcgacgg cgccgcggga cggcgggcgg tggcggtggt
    15061 gcacgccgtg tacacctccg cccgcaccgg gcgcaccgta cggctcgacg agagcagcaa
    15121 cctcacacag gacaagggga ggaccccatg agcgggaccc ttcggcaccc cgcgccggac
    15181 gagcacaagc aggccctggc ccggctcttc gaccgcagcg ccccgacgta cgaaaaggta
    15241 ggtgtctcgc acttcggcgc cctcggccgc cagttggtgg aggaggcccg tgtccgggag
    15301 ggcgagcggg tcctggacgt ggggtgcggc accggcgccg tgctcgttcc cgcggcgcga
    15361 gccgtcgggc cgagcggctc ggtgaccggc atcgacctgt ccgcgggcat ggtggagcgg
    15421 tcccgcgcgg ccatcgcgga cgaagggctg ggcaacgccc gcgccctcgt cgccgacgcc
    15481 gagaccgccc actggcagcc cggaccgccc gtcgacggta ccttcgacgc ggtactcgcc
    15541 gggatctcga tgttcttctt cccccacccc agggccgcag ccgcccgcta ccaccgactc
    15601 cttgccgacg gaggccggtt cgccatctcc tggtggggcc gccaggacga gcgctggaac
    15661 ccggtcttcg ccgccagtgc cccctacggc ggcggctcct cccaccggct cccgccggac
    15721 agtccgttcc gctccgtcga ggacctgcac gccatgctgt ccgaggaggg cttcagctcc
    15781 gtcgacaccg tggagcggac ctgtgtcacc cgcttccgcg gcccccacca gtggtggcag
    15841 tgggtgtggt ccaccgcggg ccggcagttc tgggagagcg tgcccgaaga cgcgatggcc
    15901 gacgcggtca aggcggtcga cgccgagctg gccgaactgc gcgcccccga cgggagcctg
    15961 accagccgga acatcgtccg cttcaccgtc gccgaggtcg ctcggtgagc gccgcctgca
    16021 cagcgccgca cgggtcccgt acggcggcac ccgccgccca gccgctgttc tcccgggagt
    16081 ggctgcggca cgccgaggcc gcggccgggc agcggcccga tgaaggcgag gccctccggc
    16141 tcggcctgcg cctgacgaat ccgcctgtcg gggtggccgg gcagattctc gtcctgacgg
    16201 atctggccac cggcgccctg tggttccgcg ccggcgagtg ggacgaacgg cccaccctcg
    16261 tcctgaccct ccggcacgag gaggccgccg tcctgctgtt cggggacggc gagcggcggg
    16321 tgcggctctt cgaacacgga cagctggtcc tggaaggggt gttcctcttc atcttcttcc
    16381 tggaccggct gctgcaacag gacccgtccg gggcgctggc ccggctgcgg gggttcaccg
    16441 ccgacgcgcc gcaggcggcg ggcccgtggc cggactccgc cgcgacggtc accgcgccgg
    16501 acgccgaggc cgacgcggtc cgcgccgcca ccgaggcgct gccccgtacg atggccgccc
    16561 tgcgcaccga actcggccga accacccccg gcgcccagct ccacgtcagc cacgccccga
    16621 gcggcaccac cgtctccgcc gccctgggca gctgccgccc cggagtgccc ttcacccgcg
    16681 cctccctgcc catctggtac tgctgctcca agacgctggg cgcggtggcg atcggccagt
    16741 tgtgggagcg gggcctgctg gacccggcgg cgccggtcgc acgctatctc ccctggtacg
    16801 acggcgacgg ccgcgaacgg gtcaccctct accagctgct cacccacacc tcggccgtcc
    16861 ccatgggcct ggacccgctg cacggggcca tggccgcccc ggtcgcgctc cgccgtgagc
    16921 agctgcggaa catgacggtc ccggcgggga cgccacccgg cgcgcggatc aactacgggc
    16981 cgtggtgggc gtggttcctg atcgccgagg tcgtccgcgc cgtggacgga cgcgaatacg
    17041 agcgctatct cgccgaggag atcctggcgc cctgcgggat gaccgacacc cgcgtagtgc
    17101 tcaccccaca ggagtaccgc gccgaggcgg accggctgcc actcatccac atcaccggcg
    17161 gcggcctccc ggcccagccc acccactggt acgccaccga gtcctcctgc acccggccca
    17221 tccccggcct gaacatccgc gggccgatgt ccgacctggc gctgttcttc gccgcgctgg
    17281 cggacggcgg ccgggggcgc cacgggcgca tcctgctgcc gcagaccgtc atggcgctca
    17341 ccgcgcacca ccgggtcggc ctggtggacc cgttcggcaa cgccgactgg gggctgggct
    17401 tccgcgtcga gtcccgccac ctcggcgacg agtgcacggc cttcagccgc cacgcctcgc
    17461 cgcgcacctt cggccactac gggctgtgga cctcggcggc cttcgccgac ccggacgccg
    17521 gcctggtggt cgcgctgcac ctcaacggca agacctggca ggaagagcac caggaacgaa
    17581 tgatcaccat cggtgacgcc gtctaccagg acctccggct gacctgatgc cggggcccct
    17641 tgaagcgccc gcacacgccc acaccgcagg aacggagaac cgagcatgac caccccgcag
    17701 tccgaggacg ccttcccggc cgactcaccg catgccatca tcgacgtcgc ggtcgccttc
    17761 tggaagtcca aggcgctgct gagcgcggtc gaactgggcg tgttcgaaga gcttgccgta
    17821 cgtcccgcca cccgcgccga actcaccggg aggctggaga tcgccggccg cggggccgcc
    17881 gacttcctcg acgccctggt gtccctggga ctgctggagc gcgacggcgg cgtctaccgc
    17941 aactccccgg tcgccgaccg ctacctggac cctcgcaagc ccgccaccga catctccggc
    18001 tacctctcct tcctcaacgc gggcttcggc tgctgggcag ggctgaccga cgcgctgcgc
    18061 agcggcggcc gactggactt ctccgcggcg ctggccgcct cgcggtccgc agaccagggc
    18121 ggcgccggcg acccgaagct ggtgggcgcc gacgccacgg acgacacctt cggcgaggcg
    18181 tacgccgccc cggaccaggt gaccggattc ctgcgggcga tgaccggcta cagcatgggc
    18241 gccaaccagg ccatcgcgga acggtacgac tggtcgcggt cgcggacggt cgccgatgtg
    18301 ggctgcgccg agggctcact gctggcccag gtgctgtccc ggaacccaca cctccaaggc
    18361 atcggcttcg acctgcccgt ggtcggcccc ggcttcgacg cccacctcga acgggtcggc
    18421 ctcaccgacc gggcgtgctt cgccggcggc gacttcttca ccgacccgct gccgaccgcc
    18481 gacgcgatcg tgatgggaca cgtcctgcac gactgggacc tggacaccaa gaagaccctc
    18541 atcggcaagg cgtacgaggc gctgccggag gacggccggc tgctgatcta cgagtccctg
    18601 atcgacgacg accgccgcga acgcaccacg ggcctgctga tcagcctcaa cgtctccacg
    18661 gtctcggccg gcggactggg ttacaccggt gccgagtgcg gcgactggat gcgcgcggcg
    18721 ggcttccggg acattgccgt gagccacctg gacggcccgg agtacctcgt cgtcggcgtc
    18781 aagtagcacc gcgtacgcgg ccggtgccgt gtggcgccgg ccgcgtaccc caacccgcac
    18841 gcctcccgtc acgcccccgc ggcgtccagc agccgggtga ccgactcaac gacttcgccc
    18901 ggctcccggt ctgtctctcc gggcctgatc agcgacgttc gcgtcctccc ctgcccggtc
    18961 cgggcaagcc ctgcccggta gcgcgcagcg cgaccgcgat gtggtcatat ccggggatgg
    19021 gtgacccaac ggcctcctcg taaaacacgg cgcccgcgat cccgcgtttt tctccagtgg
    19081 ggagagttcg gttcgccgtc cacacgagcg ttctcagctg ttcgtcctgg atgtcaagga
    19141 gcggggtcac ggactccagc ggcatgccgg cacgaatccg ccagtcggcg actgctccct
    19201 tgccaggcgg cgggcgcgca atcagtcgcg agcaagccgt acgcgcgctc acggagggct
    19261 tggagccatg cactttacct cgcgactgtt cacgtggatc aggaagttgc gttcaggccc
    19321 gtgtggtgag cggactgcgc gcggcggccc cgcgcaggcg atgccccaga tccgattgtg
    19381 ctggacggcc cgggcgcgtg cgcagtggtg atggtccgca ggtcgcgggg cgccgcttga
    19441 cttcttagag gacgtcccat tcaggtgcgt gttagttcat gggttgtgcc aggttgtggt
    19501 cgtttcgccg gttgctcgtt tggcgaggtt ggagagcatg gccaggcgga tcatgctctc
    19561 ggagtgttgg ggtttggttt cgtagtctcg ggccaggcgg cggtgcatca tgggccagcc
    19621 gaagcttcgc tccaccaccc agcgccgcgg tagcactgag aagcctttga cctgtgtgtt
    19681 tcgcggcacg acctcgacgt cgatgccgag ggcggcgccg tgttcgatgg cctgggtctt
    19741 gtatccggtg tcggcccatg ccttggtgat ggtggggtgg ttggcggcga cttgggtgag
    19801 gagttgtttg cctgcctggt tgtcggagac actggccgcg gtgaccatga ccagcagtaa
    19861 caggccgagg gtgtctgtga cgatgctgcg tttgcggccc acgattttct tgccggcgtc
    19921 ggtgccttgg gtgctggtgg gcacactggg agcggttttc acgctctggg catcgatgac
    19981 gcaggcagtt ggctcggcag tgcgtccttc ccgctctcgg acgatccgat gtaggtggac
    20041 gccgagcttc tcgatggtcc cgtcggcggt ccaggcactg aagtaggaga agaccgtggt
    20101 gtgcggcgga aggtcatgcg gtaggtaacg ccagggtatc ccagtccggt tgacgtagag
    20161 gattgcattg aggacttctc gcaggtcagt gaccttgccg ccgaggttga gtgaggtctt
    20221 ctgtcgctca gtgcgccagg cggtcagtgt tggctctatc agggcccagc gggcgtcgga
    20281 caggtcgctc ggatagggct tgcggggtgg ctttgtcgtc acaacatcac tgatacggca
    20341 gggagttgcg gtgaggtatc actcgtcgga gtgacctgag gtgggcgttc ttcgcgagtt
    20401 cgaaccggac aggatctacc gggcgaatca tgatgaaacg cgagcctgac ggccgacatc
    20461 accccgacgc attcggcatg agcagcctca atcagacgat ttcaggcggg caataaaacg
    20521 gccaaacccg cacgtcaaca gcatgaacgt cctctgagac cttggccatc cgaccggaag
    20581 gcgccggatc tctcatttgt gacctctaga acaggacagt gctgcggatc ggacggaaga
    20641 acgggaacat cgccttgctg tccgaaatcg ccgccgctat gaggagcaac tgacacggtc
    20701 ccccagcagg cgcccctggt ctgcaagccc tgccttgcaa ctaccgtgca gcactaaggt
    20761 gtacgacgtg acagaagcga acggggaatt gatcggcggc cggtaccgac ggatcgagct
    20821 gataggtcag ggcggcatgg gccgcgtctg gcggggtcgg gacgagacgc tcgggcggga
    20881 cgtcgccatc aaggaagtga tattcccgca gggcatcacc gccgagcagc gagacgtcct
    20941 gctccagcgt gtgacacggg aggcgcgcgc cgcagcacgg ctcaaccatc ccgggatcat
    21001 cacggtgcac gacgtggtcg aacaccaggg cgcgcccgtg atcgtcatgg aatacgtgac
    21061 cggcatctcc ctggcctcgt cgatcgcgca gagcggaggg ctgccggtcc gcacagtcgc
    21121 cgagatcggc acgaagatgc tgcaggcatt gaaccgcgcc cacgcatccg gcatcgtcca
    21181 tcgcgacctc aaaccggaca acgtcctgct gatggacgac cgggtcatca tcaccgattt
    21241 cggcatcgca cacatggcgg actcgaccac ggcgctcacc cacacaggca cgatcatcgg
    21301 cacaccggcc tacatgtcgc ccgagcagtt ggcgggcaag actccctcag ccgccaccga
    21361 cctgtgggcg ttgggcgcca cgctctacag cgccgtcgag ggtcaacccc ccttcagcgc
    21421 cgagaccttc accgcactgg tactcgccgt gatcaccgag gacccgcgcc ctgccctgcg
    21481 tgcagggggc ctgtggccgg ttcttgcggc cctgctgacg aaggatccgg cgcaacgtgc
    21541 cacggccgcg caagcgcagg ccgcgctgga gcaggtggaa cggacaggag cggccgttcc
    21601 cgttccgatc cccactcagg tcgattccgc gccgtcgccg gggccgcacg cggcacacca
    21661 gctgccaacc cagacgggca ccccgttcgc accgcccctc tccccggggt ccggcgggac
    21721 cccggcatcc ggggcgccca ggactctcgg gcggcgcagc gtcctgtggc tcggcctggg
    21781 cggggccgct gcggtggccg gcggcatcgg gatcgccctg aagacaggcg accacacccc
    21841 accgaagccc aaggtgaagc cgtgggatta caccgacgag ggcccgcgcc atgacggcaa
    21901 tccgcctccg ttcgccgtgg ccgacggcgc cctgtacgtc tccaccgagg agaccatcgt
    21961 cgccctggac gcgcgcaccg gacgcaagcg ctggaaaggc ccctccgact tctcccggga
    22021 gtacaggtac aggaaccccc tcgtggccgc cgacggggcg gtgtacgcgt ccggccagat
    22081 cggcaccacg tatggcctgt gcgcactgga cgcggacggc aggaagaagt ggttctgctc
    22141 cttcgccgac tccgaccaca gaccggtcgt gaccgacgga atcgtctaca tcacggcgta
    22201 cgaccatgtg tacgccgtgc atgcggacaa cgggcggaag ctgtggggcc atccgctggg
    22261 ggacagggac tccggcggtc tggcggtggc cgacggcacc gtgtacgtca gcggcagcaa
    22321 agccctgtac gcgctggacg cggccagcgg cgccaggaag tgggccttcc ctctcgacta
    22381 cggagcacgc atcgaccagc cacccgtcgt gtccggcgga ctcgtgtacg tcctcgacaa
    22441 tgtcacgaac ctccacgcgc tccatgccgc cgagggcacc aggaagtggt ggctcaagta
    22501 caacgggcag ggcctccgcg ccgcgggcga catgctctac gtcaccggcg gcgacgatgt
    22561 gggaaacggc atagtccacg cgctcgactc gtcgacgggg aagaggaagt ggggccacga
    22621 ggtgaactcc agtcagctgt cggccacgca gctcgcactg gccggtgacc tgctcttcgt
    22681 cgccagtacc gaggacaagg acggtaccgt ctatgccgtc gacaccggtg acggctccca
    22741 gcgctggtcc accaggcttc tggagaagct gggcagcgac atggcggccg cctacggttt
    22801 cgtgtacgcc tccatcaatg gccgtgtgat ggccctcgac gcggccacgg gggcgttcac
    22861 gatctgagca cgagcacgac atcgacgggc ggcaccagca cgccggggag cagccctgtg
    22921 ggatgaggcc gggcggccct gtgcggggcg tccttctgac gtgtgcgggg attccagagc
    22981 gcacccacgc ctggcagaac tccttccacc ggctcgcacg ctgcttcgaa cggcgggtca
    23041 ccgtcatcga tgccttcttc gacctcaccg acgcgatcat caccgtccgc agcctgatcc
    23101 gccgagcctg gaccacccac ggctgggata cacgtcctcg atgccgactg tgaccgatgc
    23161 ccggcgtacg gacgttcagg tgtcggccga cagccggtcg cccatttgca caaccgctac
    23221 cacagccatc ggcacgtcca ggattggtcg ttgatcgaac agcccccagg acgcgcctcg
    23281 ccttcggcgg cggctctctc acggggccaa gttctccggc ggcgaggttg acttgcgcga
    23341 ggcgtcgggc gcgttgttcg gggccgatgt gctcgcgcag ccgcctgtcg gccttctcgt
    23401 cccgccgcct gtcaccgcca ctcccacccg agcgccccgg agtagcacgg cctggcatcc
    23461 ctcgctaagt gacgcgagcg tggagtccgc tcgcgaccgc gggaaccgcc gtatccacgg
    23521 gatcgggcag tcgcagagcg tcgcaactct gtgatcaccg aacctgtgcc tgtcccgtct
    23581 gccgcttggc cccacccgcc ctatccgcgt ggcctcttag tctctgagga aacctcagtg
    23641 acttcacacc ttcaacggct gcggccccaa ccggcgacga gccctgccga tcgccgctgc
    23701 cgtcggtacc tgccccggct tctcgcaccg ccgcacccgt gatgccaccg gcatcccgct
    23761 cgccgccacc ccaagcgtcg gtcggggacg atctgcaaga cgaaggggcc cagcgcaggt
    23821 gatgcggccc gtcgcgtcca gggggcaccg ggcagtgccg gcctacttct ctgcggcggg
    23881 tacgaactga agacccgtct tgagatcctc acggtcgatg tcttcactca tggagatccc
    23941 cttactgcca ccgacatagc cgtagttcag tgattgtcgt agcgttccga ggatagtttt
    24001 ctcgtccctc atgttctgcg ccgcacaggt gcggtggctg gtgcttcggg tgtcgcggaa
    24061 gaagacgtgg ttgccacgaa agattgcttt gccggagaag tcgttgcagc cgagattgcc
    24121 ggtgacggtg ctgttgcgat ggaactcgaa ggaggtgtcc ttgcccgact ggaatttttc
    24181 ggtgtggtcg tagacggacc aagagttcag ccggaacttg gtgtcgaaga tactcgagtc
    24241 actgatgatg tcgaggtgac catgtcaccg tgctcgtggc gcagttgcgg cgacgagccg
    24301 ggcggcggcc cgccggggac ctgcgacagc ttcttctcag tgatgttcag ccggcctcgg
    24361 tggaggaact tcttgacctc agcctcgaaa tccgccaggt cctcgttcca cccgttgtag
    24421 tactcggctt tcgccatctg ggcatcggct ccccggtgtc tggccggccg cttcttcgag
    24481 acgcacgccc gcagacgtgc cggtgaggcg ataggcgccc tgatggacct gggcgccaag
    24541 gacgccgctg tgctccgcgg cggaagtgag gtccgcgtgc cgatcgagca gctggcggtc
    24601 ggggacgagt tcgtggtccg acccggggag aagatcgcca ccgacggggt ggtggtcgag
    24661 ggttcctcgg cggtggacga gtcgctgctg acaggtgagt cgctgccggt ggaggtcggc
    24721 ccggaggacg cggtcaccgg agcgaccgtc aacgccggag gacggctcgt cgtgcgggcc
    24781 acacgggtgg gtttggacac caagctcgcc cagatcgccc gcctggtgga ggaagcgcag
    24841 accggcaagg cggcggtgca gcggctggcg gaccagatat cggcgatctt cgtcccgatc
    24901 gccatcctcc tcgccgtcga gaccctgttc ggctggctgg tcctgggcta tccggcggcc
    24961 gtcgcactga cggcggcgac tgaccgccgt ccgaccgctg gtccctcgtc cctgactgtc
    25021 cagctgcctc agacgcgagg cggcagcgcc tcgatgatct cggcgatgcc ggcgagcggt
    25081 tgggcctcgt gcatggctat cacgtcaccg ggcttcagat gccgccactg ctctggctgc
    25141 aagggagcca g
//
